HELRO|EnsemblGenome=HelroG85944|UniProtKB=T1G648 T1G648 20216545 PTHR10778:SF10 SOLUTE CARRIER FAMILY 35 MEMBER B SOLUTE CARRIER FAMILY 35 MEMBER B1 UDP-galactose transmembrane transporter activity#GO:0005459;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nucleotide-sugar transmembrane transport#GO:0015780;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG136779|UniProtKB=T1EIF7 T1EIF7 20196357 PTHR23167:SF96 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED ALPHA ACTININ 3-RELATED organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG195039|UniProtKB=T1FWP2 T1FWP2 20213237 PTHR11119:SF3 XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER LD30822P transporter#PC00227 HELRO|EnsemblGenome=HelroG191240|UniProtKB=T1FSS2 T1FSS2 20211869 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG187844|UniProtKB=T1FPF2 T1FPF2 20210699 PTHR24345:SF89 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK4 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cell cycle process#GO:0022402;cellular process#GO:0009987;organelle organization#GO:0006996;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052 supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG179898|UniProtKB=T1FF87 T1FF87 20207486 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG77874|UniProtKB=T1G351 T1G351 20215499 PTHR24241:SF117 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE S RECEPTOR-LIKE signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG72896|UniProtKB=T1G169 T1G169 20214817 PTHR19300:SF66 BETA-1,4-GALACTOSYLTRANSFERASE BETA1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE A catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;galactosyltransferase activity#GO:0008378 carbohydrate derivative biosynthetic process#GO:1901137;glycolipid biosynthetic process#GO:0009247;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycosphingolipid biosynthetic process#GO:0006688;glycolipid metabolic process#GO:0006664;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG109653|UniProtKB=T1EEV6 T1EEV6 20195108 PTHR24406:SF36 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED TRANSCRIPTIONAL REPRESSOR CTCFL zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG152003|UniProtKB=T1EKN5 T1EKN5 20197135 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG86902|UniProtKB=T1G6I9 T1G6I9 20216686 PTHR21109:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21 SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG189623|UniProtKB=T1FR77 T1FR77 20211324 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191964|UniProtKB=T1FTG6 T1FTG6 20212113 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG67205|UniProtKB=T1FYY1 T1FYY1 20214029 PTHR15045:SF1 FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleotide-sugar metabolic process#GO:0009225;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 transferase#PC00220 HELRO|EnsemblGenome=HelroG190714|UniProtKB=T1FS81 T1FS81 20211678 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 snRNA transcription#GO:0009301;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG75623|UniProtKB=T1G276 T1G276 20215174 PTHR13360:SF1 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG189487|UniProtKB=T1FR33 T1FR33 20211280 PTHR15995:SF1 PROTEIN ZWILCH HOMOLOG PROTEIN ZWILCH HOMOLOG cell communication#GO:0007154;localization#GO:0051179;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;negative regulation of chromosome organization#GO:2001251;mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;intracellular protein localization#GO:0008104;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;negative regulation of cell cycle process#GO:0010948;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;macromolecule localization#GO:0033036;protein localization to kinetochore#GO:0034501;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of mitotic sister chromatid separation#GO:2000816;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;negative regulation of cell cycle#GO:0045786;negative regulation of chromosome segregation#GO:0051985;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;regulation of cell cycle process#GO:0010564;negative regulation of sister chromatid segregation#GO:0033046;mitotic spindle assembly checkpoint signaling#GO:0007094;signal transduction#GO:0007165;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793 HELRO|EnsemblGenome=HelroG173556|UniProtKB=T1F6Y9 T1F6Y9 20204588 PTHR13586:SF0 SCD6 PROTEIN-RELATED TRAILER HITCH, ISOFORM H RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;P-body assembly#GO:0033962;cellular process#GO:0009987;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG163862|UniProtKB=T1EUJ8 T1EUJ8 20200248 PTHR23003:SF71 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nuclear mRNA surveillance#GO:0071028;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG189004|UniProtKB=T1FQJ9 T1FQJ9 20211096 PTHR31169:SF8 OS05G0300700 PROTEIN ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG187461|UniProtKB=T1FPA0 T1FPA0 20210647 PTHR11909:SF428 CASEIN KINASE-RELATED DISCS OVERGROWN PROTEIN KINASE-RELATED protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of signal transduction#GO:0009967;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;positive regulation of Wnt signaling pathway#GO:0030177;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246;regulation of ubiquitin-dependent protein catabolic process#GO:2000058 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG162362|UniProtKB=T1ESK3 T1ESK3 20199553 PTHR16200:SF1 RING ZINC FINGER E3 UBIQUITIN-PROTEIN LIGASE PLR-1-RELATED catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG189442|UniProtKB=T1FR23 T1FR23 20211270 PTHR23294:SF0 ET TRANSLATION PRODUCT-RELATED UNC93-LIKE PROTEIN MFSD11 HELRO|EnsemblGenome=HelroG155960|UniProtKB=T1ELP7 T1ELP7 20197497 PTHR45885:SF6 CELL DIVISION CYCLE 5-LIKE PROTEIN CELL DIVISION CYCLE 5-LIKE PROTEIN DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG66489|UniProtKB=T1FYM1 T1FYM1 20213919 PTHR12879:SF8 SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 SPHINGOLIPID DELTA(4)-DESATURASE DES1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;ceramide metabolic process#GO:0006672;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 oxidoreductase#PC00176;hydroxylase#PC00122 HELRO|EnsemblGenome=HelroG173533|UniProtKB=T1F6Y3 T1F6Y3 20204582 PTHR12419:SF7 OTU DOMAIN CONTAINING PROTEIN UBIQUITINYL HYDROLASE 1 catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG188509|UniProtKB=T1FQ28 T1FQ28 20210925 PTHR23104:SF17 MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG82549|UniProtKB=T1G4T7 T1G4T7 20216085 PTHR13323:SF4 LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN RAGULATOR COMPLEX PROTEIN LAMTOR2 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of TORC1 signaling#GO:1903432;positive regulation of TORC1 signaling#GO:1904263;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to acid chemical#GO:0001101;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;vacuole#GO:0005773;cytoplasm#GO:0005737;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG164179|UniProtKB=T1EV18 T1EV18 20200418 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144824|UniProtKB=T1EJG6 T1EJG6 20196716 PTHR23138:SF87 RAN BINDING PROTEIN RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 1 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;nucleocytoplasmic transport#GO:0006913;intracellular transport#GO:0046907 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65033|UniProtKB=T1FY24 T1FY24 20213722 PTHR10887:SF341 DNA2/NAM7 HELICASE FAMILY NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulatory ncRNA-mediated heterochromatin formation#GO:0031048;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG170968|UniProtKB=T1F3N0 T1F3N0 20203429 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG161257|UniProtKB=T1ER96 T1ER96 20199096 PTHR22974:SF21 MIXED LINEAGE PROTEIN KINASE DUAL SPECIFICITY PROTEIN KINASE TTK phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic cell cycle#GO:0007346;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;regulation of reproductive process#GO:2000241;regulation of mitotic metaphase/anaphase transition#GO:0030071;sexual reproduction#GO:0019953;negative regulation of chromosome organization#GO:2001251;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;reproductive process#GO:0022414;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;chromosome segregation#GO:0007059;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;meiotic cell cycle#GO:0051321;negative regulation of chromosome segregation#GO:0051985;negative regulation of cell cycle#GO:0045786;mitotic spindle assembly checkpoint signaling#GO:0007094;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of sister chromatid segregation#GO:0033046;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;regulation of meiotic cell cycle#GO:0051445;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;meiotic cell cycle process#GO:1903046;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128 condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170970|UniProtKB=T1F3N1 T1F3N1 20203430 PTHR31996:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 115 VACUOLAR ATPASE ASSEMBLY PROTEIN VMA22 biological regulation#GO:0065007;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological quality#GO:0065008;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;vacuolar acidification#GO:0007035;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885 endoplasmic reticulum#GO:0005783;proton-transporting two-sector ATPase complex#GO:0016469;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG62417|UniProtKB=T1FX03 T1FX03 20213351 PTHR12855:SF10 DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;protein acetyltransferase complex#GO:0031248;intracellular organelle lumen#GO:0070013;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;histone acetyltransferase complex#GO:0000123;nuclear protein-containing complex#GO:0140513;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;Swr1 complex#GO:0000812;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;H4 histone acetyltransferase complex#GO:1902562;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG189846|UniProtKB=T1FRF1 T1FRF1 20211398 PTHR31691:SF1 ROTATIN ROTATIN microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;organelle assembly#GO:0070925;centriole replication#GO:0007099;cell projection organization#GO:0030030;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;microtubule organizing center organization#GO:0031023;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987 cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;centriole#GO:0005814;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG82979|UniProtKB=T1G4Y8 T1G4Y8 20216136 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG175067|UniProtKB=T1F8S9 T1F8S9 20205228 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG105292|UniProtKB=T1EDT3 T1EDT3 20194735 PTHR11647:SF1 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;dihydropyrimidinase activity#GO:0004157;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;pyrimidine nucleobase metabolic process#GO:0006206;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;primary metabolic process#GO:0044238;pyrimidine nucleobase catabolic process#GO:0006208;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HELRO|EnsemblGenome=HelroG183640|UniProtKB=T1FJZ1 T1FJZ1 20209140 PTHR21228:SF75 FAST LEU-RICH DOMAIN-CONTAINING RAP DOMAIN-CONTAINING PROTEIN RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG178880|UniProtKB=T1FDU7 T1FDU7 20206996 PTHR24416:SF539 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR PROTEIN-TYROSINE KINASE catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG91226|UniProtKB=T1G811 T1G811 20217208 PTHR10857:SF102 COPINE COPINE-3 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 response to stimulus#GO:0050896;response to calcium ion#GO:0051592;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to metal ion#GO:0010038;cellular response to chemical stimulus#GO:0070887 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG103833|UniProtKB=T1EDH7 T1EDH7 20194629 PTHR45670:SF13 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 cellular process#GO:0009987;response to stress#GO:0006950;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;DNA damage response#GO:0006974;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG85515|UniProtKB=T1G5Y3 T1G5Y3 20216480 PTHR12468:SF2 GPI MANNOSYLTRANSFERASE 2 GPI ALPHA-1,6-MANNOSYLTRANSFERASE 2 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;mannosyltransferase complex#GO:0031501;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166443|UniProtKB=T1EY51 T1EY51 20201501 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG167513|UniProtKB=T1EZF9 T1EZF9 20201959 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG179218|UniProtKB=T1FED5 T1FED5 20207184 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72745|UniProtKB=T1G147 T1G147 20214795 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG192428|UniProtKB=T1FTY4 T1FTY4 20212281 PTHR24366:SF96 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS REDUCED OCELLI, ISOFORM B immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG85694|UniProtKB=T1G618 T1G618 20216515 PTHR24044:SF512 NOTCH LIGAND FAMILY MEMBER PROTEIN LIN-12 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Next#P01103;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120 HELRO|EnsemblGenome=HelroG185679|UniProtKB=T1FN49 T1FN49 20210247 PTHR10281:SF121 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED VACUOLE MEMBRANE PROTEIN 1 intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular component organization#GO:0016043;Golgi organization#GO:0007030;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184885|UniProtKB=T1FM48 T1FM48 20209897 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 transferase#PC00220 HELRO|EnsemblGenome=HelroG166976|UniProtKB=T1EYU2 T1EYU2 20201742 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111363|UniProtKB=T1EFA6 T1EFA6 20195258 PTHR11654:SF678 OLIGOPEPTIDE TRANSPORTER-RELATED PEPTIDE TRANSPORTER FAMILY 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;dipeptide transmembrane transporter activity#GO:0071916;oligopeptide transmembrane transporter activity#GO:0035673 transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;dipeptide transport#GO:0042938;import into cell#GO:0098657;oligopeptide transport#GO:0006857;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987;import across plasma membrane#GO:0098739 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG178820|UniProtKB=T1FDS6 T1FDS6 20206975 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG189416|UniProtKB=T1FR16 T1FR16 20211263 PTHR12839:SF7 NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2 REGULATOR OF NONSENSE TRANSCRIPTS 2 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66349|UniProtKB=T1FYK0 T1FYK0 20213898 PTHR10037:SF230 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated sodium channel activity#GO:0005248;voltage-gated monoatomic cation channel activity#GO:0022843 transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;localization#GO:0051179;monoatomic cation transport#GO:0006812;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;calcium ion import#GO:0070509;action potential#GO:0001508;biological regulation#GO:0065007;metal ion transport#GO:0030001;membrane depolarization#GO:0051899 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;sodium channel complex#GO:0034706;membrane protein complex#GO:0098796;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG65195|UniProtKB=T1FY46 T1FY46 20213744 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177810|UniProtKB=T1FCA8 T1FCA8 20206457 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG187347|UniProtKB=T1FP91 T1FP91 20210638 PTHR11937:SF14 ACTIN ACTIN-RELATED PROTEIN 10 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;axo-dendritic transport#GO:0008088;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;retrograde axonal transport#GO:0008090;axonal transport#GO:0098930;organelle localization#GO:0051640 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG190092|UniProtKB=T1FRP2 T1FRP2 20211489 PTHR11766:SF0 TYROSYL-TRNA SYNTHETASE TYROSINE--TRNA LIGASE, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;translation#GO:0006412;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG163702|UniProtKB=T1EUD4 T1EUD4 20200184 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG166240|UniProtKB=T1EXX7 T1EXX7 20201427 PTHR45894:SF1 RNA-BINDING PROTEIN 8A RNA-BINDING PROTEIN 8A nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG114462|UniProtKB=T1EG21 T1EG21 20195523 PTHR24023:SF1129 COLLAGEN ALPHA MULTIPLEXIN, ISOFORM R structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG83227|UniProtKB=T1G524 T1G524 20216172 PTHR10848:SF0 MEIOTIC RECOMBINATION PROTEIN SPO11 MEIOTIC RECOMBINATION PROTEIN SPO11 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;response to stimulus#GO:0050896;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;organelle organization#GO:0006996;response to stress#GO:0006950;meiotic DNA double-strand break formation#GO:0042138;cellular process#GO:0009987;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;homologous recombination#GO:0035825;reproductive process#GO:0022414;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;DNA double-strand break processing#GO:0000729;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;chromosome#GO:0005694;nucleus#GO:0005634 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG185707|UniProtKB=T1FN63 T1FN63 20210261 PTHR11599:SF14 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-5 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;proteasome complex#GO:0000502;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG161979|UniProtKB=T1ES42 T1ES42 20199392 PTHR46513:SF41 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>LRP5/6#P01431 HELRO|EnsemblGenome=HelroG186255|UniProtKB=T1FNV6 T1FNV6 20210503 PTHR10606:SF44 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM sugar-phosphatase activity#GO:0050308;phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;transferase activity#GO:0016740;catalytic activity#GO:0003824;carbohydrate kinase activity#GO:0019200;phosphoric ester hydrolase activity#GO:0042578 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;phosphorus metabolic process#GO:0006793 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 hydrolase#PC00121;carbohydrate phosphatase#PC00066;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG154955|UniProtKB=T1ELG6 T1ELG6 20197416 PTHR12056:SF2 DNA-DIRECTED RNA POLYMERASES I, II, AND III DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;RNA polymerase I complex#GO:0005736;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66811|UniProtKB=T1FYR2 T1FYR2 20213960 PTHR12895:SF9 DYMECLIN DYMECLIN endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG183958|UniProtKB=T1FKC7 T1FKC7 20209276 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG165342|UniProtKB=T1EWM2 T1EWM2 20200972 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG185008|UniProtKB=T1FM98 T1FM98 20209947 PTHR13976:SF76 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED AT27789P ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG160521|UniProtKB=T1EQC8 T1EQC8 20198778 PTHR15606:SF4 DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED DNAJ HOMOLOG SUBFAMILY C MEMBER 8 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG176607|UniProtKB=T1FAQ2 T1FAQ2 20205901 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG80278|UniProtKB=T1G3Z4 T1G3Z4 20215792 PTHR12448:SF0 ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL ATP SYNTHASE F(1) COMPLEX SUBUNIT EPSILON, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;proton channel activity#GO:0015252;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;transporter activity#GO:0005215;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;oxidative phosphorylation#GO:0006119;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;ATP biosynthetic process#GO:0006754;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG105295|UniProtKB=T1EDT4 T1EDT4 20194736 PTHR32546:SF26 G-PROTEIN COUPLED RECEPTOR 158-RELATED SMOG, ISOFORM D G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG121655|UniProtKB=T1EGS6 T1EGS6 20195776 PTHR12428:SF66 OXA1 MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977;molecular carrier activity#GO:0140104 macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HELRO|EnsemblGenome=HelroG99671|UniProtKB=T1G9U3 T1G9U3 20217839 PTHR10880:SF48 MORTALITY FACTOR 4-LIKE PROTEIN MORTALITY FACTOR 4-LIKE PROTEIN 1 binding#GO:0005488;chromatin binding#GO:0003682 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;chromatin#GO:0000785;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG87696|UniProtKB=T1G6U5 T1G6U5 20216792 PTHR21148:SF25 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 PHOSDUCIN-LIKE PROTEIN 1 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185464|UniProtKB=T1FMU8 T1FMU8 20210147 PTHR45696:SF10 60S ACIDIC RIBOSOMAL PROTEIN P1 LARGE RIBOSOMAL SUBUNIT PROTEIN P1 binding#GO:0005488;kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;structural constituent of ribosome#GO:0003735;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;structural molecule activity#GO:0005198;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG94619|UniProtKB=T1G920 T1G920 20217567 PTHR13377:SF3 PLACENTAL PROTEIN 6 TRANSMEMBRANE PROTEIN 115 transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG141530|UniProtKB=T1EJ35 T1EJ35 20196585 PTHR46756:SF29 TRANSGELIN GAS2-LIKE PROTEIN PICKLED EGGS binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;protein localization to microtubule cytoskeleton#GO:0072698;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;regulation of microtubule polymerization or depolymerization#GO:0031110;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;actin filament organization#GO:0007015;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;protein localization to organelle#GO:0033365;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of microtubule-based process#GO:0032886;actin filament-based process#GO:0030029;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;supramolecular fiber organization#GO:0097435 actomyosin#GO:0042641;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;stress fiber#GO:0001725;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule plus-end#GO:0035371;microtubule end#GO:1990752;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin filament bundle#GO:0032432;microtubule#GO:0005874 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG183618|UniProtKB=T1FJY0 T1FJY0 20209129 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168825|UniProtKB=T1F105 T1F105 20202505 PTHR11360:SF325 MONOCARBOXYLATE TRANSPORTER EG:103B4.3 PROTEIN monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG165169|UniProtKB=T1EWD2 T1EWD2 20200882 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG75680|UniProtKB=T1G287 T1G287 20215185 PTHR22811:SF14 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN LP01981P-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular protein transport#GO:0006886 COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG168135|UniProtKB=T1F076 T1F076 20202226 PTHR46680:SF3 NF-KAPPA-B INHIBITOR ALPHA NF-KAPPA-B INHIBITOR CACTUS DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;protein sequestering activity#GO:0140311;transcription factor binding#GO:0008134;binding#GO:0005488;molecular sequestering activity#GO:0140313 negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Toll pathway-drosophila#P06217>CACT#P06342 HELRO|EnsemblGenome=HelroG113622|UniProtKB=T1EFU3 T1EFU3 20195445 PTHR46116:SF39 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME DUAL E2 UBIQUITIN-CONJUGATING ENZYME_E3 UBIQUITIN-PROTEIN LIGASE BIRC6 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity#GO:0003824;transferase activity#GO:0016740 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG171208|UniProtKB=T1F3Y0 T1F3Y0 20203529 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN binding#GO:0005488;hormone binding#GO:0042562;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;molecular transducer activity#GO:0060089 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG98540|UniProtKB=T1G9N5 T1G9N5 20217781 PTHR10751:SF29 GUANYLATE BINDING PROTEIN ATLASTIN hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 G-protein#PC00020;heterotrimeric G-protein#PC00117 HELRO|EnsemblGenome=HelroG192579|UniProtKB=T1FU32 T1FU32 20212328 PTHR24115:SF1024 KINESIN-RELATED LP17758P catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515 cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG173258|UniProtKB=T1F6M0 T1F6M0 20204469 PTHR12857:SF0 CXXC MOTIF CONTAINING ZINC BINDING PROTEIN CXXC MOTIF CONTAINING ZINC BINDING PROTEIN metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914 HELRO|EnsemblGenome=HelroG188096|UniProtKB=T1FPM5 T1FPM5 20210772 PTHR14130:SF14 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 92B molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG89391|UniProtKB=T1G7C7 T1G7C7 20216974 PTHR13759:SF10 TWINFILIN TWINFILIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;actin monomer binding#GO:0003785;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;protein-containing complex disassembly#GO:0032984;regulation of actin filament depolymerization#GO:0030834;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;supramolecular fiber organization#GO:0097435;negative regulation of protein-containing complex assembly#GO:0031333;regulation of cell projection assembly#GO:0060491;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;protein depolymerization#GO:0051261;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;regulation of plasma membrane bounded cell projection organization#GO:0120035;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component disassembly#GO:0022411;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin filament length#GO:0030832;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;actin filament depolymerization#GO:0030042;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;regulation of anatomical structure size#GO:0090066 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG163497|UniProtKB=T1EU48 T1EU48 20200098 PTHR23320:SF130 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED TRANSMEMBRANE PROTEIN 212 transporter#PC00227 HELRO|EnsemblGenome=HelroG162440|UniProtKB=T1ESN4 T1ESN4 20199584 PTHR15592:SF14 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG151021|UniProtKB=T1EKI3 T1EKI3 20197083 PTHR11599:SF244 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-1 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;proteasome complex#GO:0000502;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG103151|UniProtKB=T1EDE4 T1EDE4 20194596 PTHR10333:SF89 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;Sin3-type complex#GO:0070822;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG194928|UniProtKB=T1FWK8 T1FWK8 20213203 PTHR37283:SF1 PH DOMAIN-CONTAINING PROTEIN YHR131C PH DOMAIN-CONTAINING PROTEIN YHR131C HELRO|EnsemblGenome=HelroG74350|UniProtKB=T1G1P9 T1G1P9 20214997 PTHR23359:SF234 NUCLEOTIDE KINASE ADENYLATE KINASE 2, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleoside phosphate biosynthetic process#GO:1901293;ADP metabolic process#GO:0046031;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside diphosphate metabolic process#GO:0009132;organophosphate biosynthetic process#GO:0090407;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG171223|UniProtKB=T1F3Y7 T1F3Y7 20203536 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN hormone binding#GO:0042562;binding#GO:0005488;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG90804|UniProtKB=T1G7W6 T1G7W6 20217163 PTHR24054:SF0 CASEIN KINASE II SUBUNIT ALPHA CASEIN KINASE II SUBUNIT ALPHA protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to stress#GO:0006950;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 Parkinson disease#P00049>Casein kinase II#P01236;Wnt signaling pathway#P00057>Casein Kinase 2#P01459;Cadherin signaling pathway#P00012>Casein kinase II#P00462 HELRO|EnsemblGenome=HelroG184879|UniProtKB=T1FM44 T1FM44 20209893 PTHR12046:SF0 HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG162559|UniProtKB=T1ESU2 T1ESU2 20199642 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;muscle system process#GO:0003012;cellular component organization#GO:0016043;organelle organization#GO:0006996;system process#GO:0003008;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;muscle contraction#GO:0006936 cytoskeleton#GO:0005856;actin filament#GO:0005884;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG192976|UniProtKB=T1FUH1 T1FUH1 20212467 PTHR23255:SF71 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE BABO protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;signaling receptor activity#GO:0038023;activin binding#GO:0048185;kinase activity#GO:0016301;transferase activity#GO:0016740;molecular transducer activity#GO:0060089;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824 transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;activin receptor signaling pathway#GO:0032924 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 serine/threonine protein kinase receptor#PC00205 Activin beta signaling pathway#P06210>BABO#P06231;MYO signaling pathway#P06215>BABO#P06310;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;ALP23B signaling pathway#P06209>BABO#P06220;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442 HELRO|EnsemblGenome=HelroG65616|UniProtKB=T1FYA6 T1FYA6 20213804 PTHR12300:SF197 HVA22-LIKE PROTEINS LP05237P-RELATED binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 endomembrane system organization#GO:0010256;endoplasmic reticulum tubular network organization#GO:0071786;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 endoplasmic reticulum#GO:0005783;cytoskeleton#GO:0005856;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874;cytoplasmic microtubule#GO:0005881;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184716|UniProtKB=T1FLU6 T1FLU6 20209795 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG112195|UniProtKB=T1EFH6 T1EFH6 20195328 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG193324|UniProtKB=T1FUW0 T1FUW0 20212606 PTHR11822:SF44 NADP-SPECIFIC ISOCITRATE DEHYDROGENASE ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC pyridine-containing compound metabolic process#GO:0072524;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;nicotinamide nucleotide metabolic process#GO:0046496;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;NADP+ metabolic process#GO:0006739;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 microbody#GO:0042579;mitochondrion#GO:0005739;peroxisome#GO:0005777;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192173|UniProtKB=T1FTN5 T1FTN5 20212182 PTHR46534:SF1 IGGFC_BINDING DOMAIN-CONTAINING PROTEIN IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66983|UniProtKB=T1FYU6 T1FYU6 20213994 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG64313|UniProtKB=T1FXS6 T1FXS6 20213624 PTHR14744:SF15 N-ALPHA-ACETYLTRANSFERASE 60 N-ALPHA-ACETYLTRANSFERASE 60 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186 cell cycle#GO:0007049;chromosome segregation#GO:0007059;cellular process#GO:0009987;cell cycle process#GO:0022402 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG176316|UniProtKB=T1FAD9 T1FAD9 20205788 PTHR14918:SF4 KICSTOR COMPLEX PROTEIN SZT2 PROTEIN SZT2 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of TORC1 signaling#GO:1903432;negative regulation of TORC1 signaling#GO:1904262;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of TOR signaling#GO:0032006;response to nutrient levels#GO:0031667 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579 HELRO|EnsemblGenome=HelroG110482|UniProtKB=T1EF27 T1EF27 20195179 PTHR24223:SF447 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 transport#GO:0006810;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG63410|UniProtKB=T1FXF5 T1FXF5 20213503 PTHR24343:SF345 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG175454|UniProtKB=T1F998 T1F998 20205397 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG188635|UniProtKB=T1FQ72 T1FQ72 20210969 PTHR19432:SF37 SUGAR TRANSPORTER SOLUTE CARRIER FAMILY 45 MEMBER 3 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;solute:proton symporter activity#GO:0015295;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG163338|UniProtKB=T1ETX7 T1ETX7 20200027 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184995|UniProtKB=T1FM89 T1FM89 20209938 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HELRO|EnsemblGenome=HelroG64886|UniProtKB=T1FY07 T1FY07 20213705 PTHR10410:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT H catalytic activity#GO:0003824;translation factor activity#GO:0180051;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;translation initiation factor activity#GO:0003743;ubiquitin-like protein peptidase activity#GO:0019783;metallopeptidase activity#GO:0008237;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;eukaryotic translation initiation factor 3 complex#GO:0005852 translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG159371|UniProtKB=T1ENY6 T1ENY6 20198286 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR MELATONIN RECEPTOR PDCR-1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62642|UniProtKB=T1FX30 T1FX30 20213378 PTHR12932:SF9 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;positive regulation of cellular component organization#GO:0051130;microtubule bundle formation#GO:0001578;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;protein polymerization#GO:0051258;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996 intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG62260|UniProtKB=T1FWY0 T1FWY0 20213328 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;bicarbonate transmembrane transporter activity#GO:0015106;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;biological regulation#GO:0065007;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;localization#GO:0051179;regulation of biological quality#GO:0065008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG102735|UniProtKB=T1EDB3 T1EDB3 20194565 PTHR10536:SF0 DNA PRIMASE SMALL SUBUNIT DNA PRIMASE SMALL SUBUNIT catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;replisome#GO:0030894;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596 primase#PC00189 DNA replication#P00017>Primase#P00528 HELRO|EnsemblGenome=HelroG178674|UniProtKB=T1FDJ9 T1FDJ9 20206898 PTHR10270:SF161 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG194042|UniProtKB=T1FVL7 T1FVL7 20212863 PTHR16431:SF1 NEUROGENIC PROTEIN MASTERMIND NEUROGENIC PROTEIN MASTERMIND chromatin organization#GO:0006325;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;kinetochore organization#GO:0051383;kinetochore assembly#GO:0051382;organelle assembly#GO:0070925 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG103469|UniProtKB=T1EDG3 T1EDG3 20194615 PTHR12203:SF126 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED PROTEIN O-GLUCOSYLTRANSFERASE 1 pentosyltransferase activity#GO:0016763;xylosyltransferase activity#GO:0042285;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;UDP-glucosyltransferase activity#GO:0035251;UDP-xylosyltransferase activity#GO:0035252;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 glycoprotein metabolic process#GO:0009100;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;biosynthetic process#GO:0009058;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;positive regulation of Notch signaling pathway#GO:0045747;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG165920|UniProtKB=T1EXG5 T1EXG5 20201265 PTHR24230:SF166 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169427|UniProtKB=T1F1X1 T1F1X1 20202821 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG186090|UniProtKB=T1FNN2 T1FNN2 20210429 PTHR45633:SF53 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL 60 KDA HEAT SHOCK PROTEIN HOMOLOG 1, MITOCHONDRIAL-RELATED binding#GO:0005488;protein-folding chaperone binding#GO:0051087;protein binding#GO:0005515 metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;response to stress#GO:0006950;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;cellular response to stress#GO:0033554;response to unfolded protein#GO:0006986;cellular localization#GO:0051641;cellular component organization#GO:0016043;apoptotic process#GO:0006915;response to stimulus#GO:0050896;mitochondrial transport#GO:0006839;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;intracellular transport#GO:0046907;transport#GO:0006810;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;macromolecule biosynthetic process#GO:0009059;mitochondrial protein import pathway#GO:7770058;biosynthetic process#GO:0009058;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;localization#GO:0051179;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle membrane#GO:0031090;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966 HELRO|EnsemblGenome=HelroG70089|UniProtKB=T1G026 T1G026 20214424 PTHR12981:SF0 ZINC FINGER PROTEIN-LIKE 1 ZINC FINGER PROTEIN-LIKE 1 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG83935|UniProtKB=T1G5C0 T1G5C0 20216267 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG62561|UniProtKB=T1FX24 T1FX24 20213372 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG88186|UniProtKB=T1G6Z5 T1G6Z5 20216842 PTHR13306:SF6 TRANSMEMBRANE PROTEIN 138 TRANSMEMBRANE PROTEIN 138 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987 cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG105060|UniProtKB=T1EDQ2 T1EDQ2 20194704 PTHR13186:SF0 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG166464|UniProtKB=T1EY57 T1EY57 20201507 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG190175|UniProtKB=T1FRR6 T1FRR6 20211513 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG187063|UniProtKB=T1FP66 T1FP66 20210613 PTHR13237:SF9 SOMETHING ABOUT SILENCING PROTEIN 10-RELATED NEUROGUIDIN ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG134347|UniProtKB=T1EI45 T1EI45 20196245 PTHR13464:SF0 TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP SAP30-BINDING PROTEIN cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG180213|UniProtKB=T1FFK9 T1FFK9 20207608 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P protein metabolic process#GO:0019538;protein refolding#GO:0042026;response to stimulus#GO:0050896;protein folding#GO:0006457;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to stress#GO:0006950;response to heat#GO:0009408;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG191234|UniProtKB=T1FSR8 T1FSR8 20211865 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG189694|UniProtKB=T1FR95 T1FR95 20211342 PTHR23320:SF176 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED SUBFAMILY NOT NAMED transporter#PC00227 HELRO|EnsemblGenome=HelroG180301|UniProtKB=T1FFQ0 T1FFQ0 20207649 PTHR11088:SF89 TRNA DIMETHYLALLYLTRANSFERASE TRNA DIMETHYLALLYLTRANSFERASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG68132|UniProtKB=T1FZA7 T1FZA7 20214155 PTHR24058:SF12 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transcription regulator activity#GO:0140110;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185033|UniProtKB=T1FMB3 T1FMB3 20209962 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG109215|UniProtKB=T1EER4 T1EER4 20195066 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG167896|UniProtKB=T1EZX7 T1EZX7 20202127 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164019|UniProtKB=T1EUS1 T1EUS1 20200321 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172599|UniProtKB=T1F5L2 T1F5L2 20204111 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG169349|UniProtKB=T1F1T5 T1F1T5 20202785 PTHR19336:SF14 UNCHARACTERIZED DUF1167 CENTROSOMAL PROTEIN OF 57 KDA protein binding#GO:0005515;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;microtubule binding#GO:0008017;molecular adaptor activity#GO:0060090;tubulin binding#GO:0015631;cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092 microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;chromosome localization#GO:0050000;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG189320|UniProtKB=T1FQY3 T1FQY3 20211230 PTHR13693:SF108 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 5-AMINOLEVULINATE SYNTHASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;heme biosynthetic process#GO:0006783;pigment metabolic process#GO:0042440;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tetrapyrrole biosynthetic process#GO:0033014;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;porphyrin-containing compound biosynthetic process#GO:0006779;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transaminase#PC00216 HELRO|EnsemblGenome=HelroG115201|UniProtKB=T1EG72 T1EG72 20195574 PTHR18034:SF3 CELL CYCLE CONTROL PROTEIN CWF22-RELATED PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397 U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG68493|UniProtKB=T1FZF7 T1FZF7 20214205 PTHR22760:SF2 GLYCOSYLTRANSFERASE ALPHA-1,2-MANNOSYLTRANSFERASE ALG9 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG76604|UniProtKB=T1G2M2 T1G2M2 20215320 PTHR11164:SF0 GLUTAMATE CYSTEINE LIGASE GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879 biosynthetic process#GO:0009058;peptide metabolic process#GO:0006518;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160526|UniProtKB=T1EQC9 T1EQC9 20198779 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 endothelial cell migration#GO:0043542;cell motility#GO:0048870;cell migration#GO:0016477;cellular process#GO:0009987 cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG169015|UniProtKB=T1F195 T1F195 20202595 PTHR24056:SF597 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 12 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64571|UniProtKB=T1FXW6 T1FXW6 20213664 PTHR11043:SF0 ZETA-COAT PROTEIN COATOMER SUBUNIT ZETA vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;intra-Golgi vesicle-mediated transport#GO:0006891;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;COPI vesicle coat#GO:0030126;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;vesicle membrane#GO:0012506;membrane#GO:0016020;COPI-coated vesicle#GO:0030137;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG133549|UniProtKB=T1EI13 T1EI13 20196213 PTHR12416:SF3 RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488 ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG179294|UniProtKB=T1FEH9 T1FEH9 20207228 PTHR20967:SF0 PROHORMONE-4 PROHORMONE-4 HELRO|EnsemblGenome=HelroG89375|UniProtKB=T1G7C5 T1G7C5 20216972 PTHR10366:SF853 NAD DEPENDENT EPIMERASE/DEHYDRATASE GH25466P oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 dehydratase#PC00091;lyase#PC00144;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186112|UniProtKB=T1FNN7 T1FNN7 20210434 PTHR13375:SF3 FMS INTERACTING PROTEIN THO COMPLEX SUBUNIT 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 gene expression#GO:0010467;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;localization#GO:0051179;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913 THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;transcription export complex#GO:0000346 HELRO|EnsemblGenome=HelroG82595|UniProtKB=T1G4U2 T1G4U2 20216090 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174253|UniProtKB=T1F7W2 T1F7W2 20204911 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193850|UniProtKB=T1FVF0 T1FVF0 20212796 PTHR46205:SF5 LOQUACIOUS, ISOFORM B BLANKS-RELATED RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;siRNA processing#GO:0030422;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG88095|UniProtKB=T1G6Y4 T1G6Y4 20216831 PTHR24073:SF1235 DRAB5-RELATED RAS-RELATED PROTEIN RAB-21 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG180063|UniProtKB=T1FFF5 T1FFF5 20207554 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG139427|UniProtKB=T1EIY7 T1EIY7 20196537 PTHR10082:SF60 INTEGRIN BETA SUBUNIT INTEGRIN BETA-PS cell adhesion molecule binding#GO:0050839;binding#GO:0005488;signaling receptor binding#GO:0005102;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell adhesion mediated by integrin#GO:0033627;cell surface receptor signaling pathway#GO:0007166;cell migration#GO:0016477;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;cellular process#GO:0009987 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell-substrate junction#GO:0030055;plasma membrane#GO:0005886;focal adhesion#GO:0005925 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HELRO|EnsemblGenome=HelroG86209|UniProtKB=T1G685 T1G685 20216582 PTHR46030:SF1 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6 RNA_DNA DEMETHYLASE ALKBH6-RELATED catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG66644|UniProtKB=T1FYN4 T1FYN4 20213932 PTHR13693:SF3 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE C-PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281 protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 transaminase#PC00216 HELRO|EnsemblGenome=HelroG82157|UniProtKB=T1G4N7 T1G4N7 20216035 PTHR11566:SF67 DYNAMIN DYNAMIN-LIKE GTPASE OPA1, MITOCHONDRIAL hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924;microtubule binding#GO:0008017;protein binding#GO:0005515;hydrolase activity#GO:0016787;tubulin binding#GO:0015631;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization#GO:0016043;mitochondrial fusion#GO:0008053;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;organelle fusion#GO:0048284;mitochondrion organization#GO:0007005 organelle envelope#GO:0031967;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;microtubule#GO:0005874;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial intermembrane space#GO:0005758;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG82965|UniProtKB=T1G4Y5 T1G4Y5 20216133 PTHR23116:SF40 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED PDZ DOMAIN-CONTAINING PROTEIN intracellular organelle#GO:0043229;cilium#GO:0005929;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;stereocilium#GO:0032420;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG192974|UniProtKB=T1FUH0 T1FUH0 20212466 PTHR11592:SF135 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;cellular response to oxidative stress#GO:0034599;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185535|UniProtKB=T1FMX9 T1FMX9 20210178 PTHR24345:SF93 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK1 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;cell cycle process#GO:0022402;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017 chromosome#GO:0005694;spindle pole#GO:0000922;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG168024|UniProtKB=T1F027 T1F027 20202177 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94522|UniProtKB=T1G917 T1G917 20217564 PTHR22748:SF4 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2 phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;DNA exonuclease activity#GO:0004529;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;exonuclease activity#GO:0004527;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG157348|UniProtKB=T1EM99 T1EM99 20197699 PTHR10176:SF3 GLYCOGEN SYNTHASE GLYCOGEN [STARCH] SYNTHASE glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 glucan biosynthetic process#GO:0009250;energy reserve metabolic process#GO:0006112;polysaccharide biosynthetic process#GO:0000271;polysaccharide metabolic process#GO:0005976;carbohydrate metabolic process#GO:0005975;glycogen metabolic process#GO:0005977;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;glycogen biosynthetic process#GO:0005978;biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG63155|UniProtKB=T1FXB7 T1FXB7 20213465 PTHR20856:SF5 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;RNA polymerase I complex#GO:0005736;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HELRO|EnsemblGenome=HelroG68894|UniProtKB=T1FZK8 T1FZK8 20214256 PTHR11802:SF3 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180;serine hydrolase activity#GO:0017171 serine protease#PC00203 HELRO|EnsemblGenome=HelroG110065|UniProtKB=T1EEZ0 T1EEZ0 20195142 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG193188|UniProtKB=T1FUQ3 T1FUQ3 20212549 PTHR10900:SF124 PERIOSTIN-RELATED FASCICLIN-1 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 extracellular structure organization#GO:0043062;cell adhesion#GO:0007155;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG84957|UniProtKB=T1G5Q9 T1G5Q9 20216406 PTHR23113:SF363 GUANINE NUCLEOTIDE EXCHANGE FACTOR PROTEIN SON OF SEVENLESS guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 Ras Pathway#P04393>SOS#P04552;Integrin signalling pathway#P00034>SOS#P00920;PDGF signaling pathway#P00047>SOS#P01159;EGF receptor signaling pathway#P00018>SOS#P00558;Angiogenesis#P00005>SOS-1#P00193;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;FGF signaling pathway#P00021>SOS#P00641 HELRO|EnsemblGenome=HelroG173200|UniProtKB=T1F6J8 T1F6J8 20204447 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78298|UniProtKB=T1G3A5 T1G3A5 20215553 PTHR11817:SF3 PYRUVATE KINASE AT14039P-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;pyruvate kinase activity#GO:0004743;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HELRO|EnsemblGenome=HelroG164640|UniProtKB=T1EVN7 T1EVN7 20200637 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG177811|UniProtKB=T1FCA9 T1FCA9 20206458 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155122|UniProtKB=T1ELH0 T1ELH0 20197420 PTHR23349:SF50 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST PROTEIN TWIST sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG180762|UniProtKB=T1FG89 T1FG89 20207838 PTHR13198:SF4 RING FINGER PROTEIN 25 E3 UBIQUITIN-PROTEIN LIGASE RNF25 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 metabolic process#GO:0008152;translational elongation#GO:0006414;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein catabolic process#GO:0030163;translation#GO:0006412;modification-dependent macromolecule catabolic process#GO:0043632;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;rescue of stalled cytosolic ribosome#GO:0072344;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cytoplasmic translation#GO:0002181;catabolic process#GO:0009056;protein biosynthetic process#GO:0160307 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG133479|UniProtKB=T1EI11 T1EI11 20196211 PTHR24416:SF647 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cell migration#GO:0016477;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG86412|UniProtKB=T1G6B8 T1G6B8 20216615 PTHR10264:SF137 BAND 7 PROTEIN-RELATED GH04404P1 channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG166131|UniProtKB=T1EXT9 T1EXT9 20201389 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG143846|UniProtKB=T1EJC6 T1EJC6 20196676 PTHR46191:SF2 FAMILY NOT NAMED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG153338|UniProtKB=T1EL42 T1EL42 20197292 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG193037|UniProtKB=T1FUJ9 T1FUJ9 20212495 PTHR43831:SF1 ISOBUTYRYL-COA DEHYDROGENASE ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188801|UniProtKB=T1FQD6 T1FQD6 20211033 PTHR10589:SF28 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG160784|UniProtKB=T1EQQ2 T1EQQ2 20198902 PTHR46630:SF3 TETRATRICOPEPTIDE REPEAT PROTEIN 29 TETRATRICOPEPTIDE REPEAT PROTEIN 29 cilium movement#GO:0003341;cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG76119|UniProtKB=T1G2F2 T1G2F2 20215250 PTHR10663:SF402 GUANYL-NUCLEOTIDE EXCHANGE FACTOR MIP16918P membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG177697|UniProtKB=T1FC34 T1FC34 20206383 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;regulation of metabolic process#GO:0019222;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;regulation of cellular response to stress#GO:0080135;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG101724|UniProtKB=T1ED64 T1ED64 20194516 PTHR43400:SF7 FUMARATE REDUCTASE FUMARATE REDUCTASE (NADH) cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG166978|UniProtKB=T1EYU4 T1EYU4 20201744 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164746|UniProtKB=T1EVR8 T1EVR8 20200668 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG64291|UniProtKB=T1FXS4 T1FXS4 20213622 PTHR31746:SF3 TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER TRANSMEMBRANE PROTEIN 229B HELRO|EnsemblGenome=HelroG74739|UniProtKB=T1G1V1 T1G1V1 20215049 PTHR45620:SF42 PDF RECEPTOR-LIKE PROTEIN-RELATED G PROTEIN-COUPLED RECEPTOR SEB-2 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG186289|UniProtKB=T1FNX5 T1FNX5 20210522 PTHR13296:SF0 BCAS2 PROTEIN PRE-MRNA-SPLICING FACTOR SPF27 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG105001|UniProtKB=T1EDP7 T1EDP7 20194699 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;steroid metabolic process#GO:0008202;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG103603|UniProtKB=T1EDG6 T1EDG6 20194618 PTHR10644:SF26 DNA REPAIR/RNA PROCESSING CPSF FAMILY CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1 nucleus#GO:0005634;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190007|UniProtKB=T1FRL1 T1FRL1 20211458 PTHR14312:SF1 CREB/ATF BZIP TRANSCRIPTION FACTOR BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG180002|UniProtKB=T1FFB7 T1FFB7 20207516 PTHR11905:SF247 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG188692|UniProtKB=T1FQ95 T1FQ95 20210992 PTHR37456:SF15 SI:CH211-266K2.1 MULTIPLEXIN HELRO|EnsemblGenome=HelroG176761|UniProtKB=T1FAW0 T1FAW0 20205959 PTHR46458:SF1 BLR2807 PROTEIN NEUROGLOBIN molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;binding#GO:0005488 establishment of localization#GO:0051234;localization#GO:0051179;response to hypoxia#GO:0001666;transport#GO:0006810;response to stimulus#GO:0050896;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293 transporter#PC00227 HELRO|EnsemblGenome=HelroG117203|UniProtKB=T1EGL0 T1EGL0 20195710 PTHR22973:SF12 LD35087P LD35087P HELRO|EnsemblGenome=HelroG180282|UniProtKB=T1FFP1 T1FFP1 20207640 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG194482|UniProtKB=T1FW39 T1FW39 20213035 PTHR46830:SF1 TRANSFERASE, PUTATIVE-RELATED ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220 HELRO|EnsemblGenome=HelroG164276|UniProtKB=T1EV71 T1EV71 20200471 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186187|UniProtKB=T1FNS3 T1FNS3 20210470 PTHR45841:SF1 MRNA TURNOVER PROTEIN 4 MRTO4 MRNA TURNOVER PROTEIN 4 HOMOLOG RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;preribosome, large subunit precursor#GO:0030687;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG194467|UniProtKB=T1FW31 T1FW31 20213027 PTHR12460:SF40 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG177732|UniProtKB=T1FC55 T1FC55 20206404 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193527|UniProtKB=T1FV31 T1FV31 20212677 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG181853|UniProtKB=T1FHE4 T1FHE4 20208243 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67442|UniProtKB=T1FZ09 T1FZ09 20214057 PTHR22957:SF704 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG126295|UniProtKB=T1EH92 T1EH92 20195942 PTHR22978:SF48 B-CELL TRANSLOCATION GENE ANTI-PROLIFERATIVE PROTEIN DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;negative regulation of cell population proliferation#GO:0008285;negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161460|UniProtKB=T1ERH8 T1ERH8 20199178 PTHR31796:SF2 SUZ DOMAIN-CONTAINING PROTEIN 1 SUZ RNA-BINDING DOMAIN-CONTAINING HELRO|EnsemblGenome=HelroG186615|UniProtKB=T1FP16 T1FP16 20210563 PTHR45695:SF9 LEUCOKININ RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173431|UniProtKB=T1F6T6 T1F6T6 20204535 PTHR16148:SF24 NF-KAPPA-B-REPRESSING FACTOR-RELATED LD33178P nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG177464|UniProtKB=T1FBQ6 T1FBQ6 20206255 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177755|UniProtKB=T1FC72 T1FC72 20206421 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188506|UniProtKB=T1FQ25 T1FQ25 20210922 PTHR11662:SF465 SOLUTE CARRIER FAMILY 17 SIALIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG178780|UniProtKB=T1FDQ4 T1FDQ4 20206953 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG174327|UniProtKB=T1F806 T1F806 20204955 PTHR33244:SF8 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72480|UniProtKB=T1G106 T1G106 20214754 PTHR42884:SF35 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 2 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;proteolysis#GO:0006508;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;peptide hormone processing#GO:0016486;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG169610|UniProtKB=T1F259 T1F259 20202909 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG122541|UniProtKB=T1EGU9 T1EGU9 20195799 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HELRO|EnsemblGenome=HelroG164759|UniProtKB=T1EVS1 T1EVS1 20200671 PTHR11422:SF0 T-CELL SURFACE GLYCOPROTEIN CD4 T-CELL SURFACE GLYCOPROTEIN CD4 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG63722|UniProtKB=T1FXJ2 T1FXJ2 20213540 PTHR31978:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG INTRAFLAGELLAR TRANSPORT 20 localization#GO:0051179;cilium organization#GO:0044782;organelle assembly#GO:0070925;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;ciliary base#GO:0097546;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;centrosome#GO:0005813;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG157109|UniProtKB=T1EM62 T1EM62 20197662 PTHR10585:SF14 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR signal sequence receptor activity#GO:0005048 intracellular protein localization#GO:0008104;cellular localization#GO:0051641;protein localization to organelle#GO:0033365;localization#GO:0051179;cellular process#GO:0009987;macromolecule localization#GO:0033036 cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG92191|UniProtKB=T1G8C8 T1G8C8 20217325 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG173292|UniProtKB=T1F6N2 T1F6N2 20204481 PTHR31786:SF2 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24 chromatin binding#GO:0003682;binding#GO:0005488 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Fanconi anaemia nuclear complex#GO:0043240;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG65417|UniProtKB=T1FY75 T1FY75 20213773 PTHR11662:SF465 SOLUTE CARRIER FAMILY 17 SIALIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG181213|UniProtKB=T1FGR2 T1FGR2 20208011 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164490|UniProtKB=T1EVH9 T1EVH9 20200579 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159992|UniProtKB=T1EPM7 T1EPM7 20198527 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182570|UniProtKB=T1FID4 T1FID4 20208583 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG82279|UniProtKB=T1G4Q1 T1G4Q1 20216049 PTHR11636:SF5 POU DOMAIN POU DOMAIN MOTIF 3, ISOFORM F sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG91068|UniProtKB=T1G7Z3 T1G7Z3 20217190 PTHR48021:SF1 FAMILY NOT NAMED MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185294|UniProtKB=T1FMM4 T1FMM4 20210073 PTHR45715:SF23 ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED ATPASE H+ TRANSPORTING V1 SUBUNIT E1 ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 membrane#GO:0016020;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG162255|UniProtKB=T1ESF3 T1ESF3 20199503 PTHR11841:SF3 REELIN EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG106880|UniProtKB=T1EE56 T1EE56 20194858 PTHR45876:SF8 FI04035P RHO GTPASE-ACTIVATING PROTEIN 39 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG112898|UniProtKB=T1EFN1 T1EFN1 20195383 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA biosynthetic process#GO:0032774;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mRNA processing#GO:0006397;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;nucleic acid biosynthetic process#GO:0141187 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG84274|UniProtKB=T1G5G8 T1G5G8 20216315 PTHR22589:SF14 CARNITINE O-ACYLTRANSFERASE CHOLINE O-ACETYLTRANSFERASE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 anterograde trans-synaptic signaling#GO:0098916;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;biosynthetic process#GO:0009058;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular process#GO:0009987;cell communication#GO:0007154;metabolic process#GO:0008152;trans-synaptic signaling#GO:0099537;neuromuscular synaptic transmission#GO:0007274 neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CAT#P01076;Nicotinic acetylcholine receptor signaling pathway#P00044>CAT#P01087;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>CAT#P01063 HELRO|EnsemblGenome=HelroG186284|UniProtKB=T1FNX0 T1FNX0 20210517 PTHR11699:SF211 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1 catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity#GO:0016491 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG113696|UniProtKB=T1EFV2 T1EFV2 20195454 PTHR45721:SF11 LAMIN DM0-RELATED LAMIN-RELATED structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cellular localization#GO:0051641;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;localization#GO:0051179;localization within membrane#GO:0051668;organelle localization#GO:0051640;regulation of macromolecule metabolic process#GO:0060255;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;intracellular protein localization#GO:0008104;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;nucleus organization#GO:0006997;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;chromatin organization#GO:0006325;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 FAS signaling pathway#P00020>Nuclear Lamin#P00616 HELRO|EnsemblGenome=HelroG73066|UniProtKB=T1G195 T1G195 20214843 PTHR10751:SF29 GUANYLATE BINDING PROTEIN ATLASTIN hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 G-protein#PC00020;heterotrimeric G-protein#PC00117 HELRO|EnsemblGenome=HelroG186209|UniProtKB=T1FNT6 T1FNT6 20210483 PTHR11911:SF111 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693 dehydrogenase#PC00092 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HELRO|EnsemblGenome=HelroG67692|UniProtKB=T1FZ40 T1FZ40 20214088 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG166314|UniProtKB=T1EY06 T1EY06 20201456 PTHR13832:SF803 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE CG10417-RELATED phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG108353|UniProtKB=T1EEI4 T1EEI4 20194986 PTHR11806:SF4 GLUCOSE INHIBITED DIVISION PROTEIN A 5-TAURINOMETHYLURIDINE-[TRNA] SYNTHASE SUBUNIT MTO1, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640 mitochondrial RNA processing#GO:0000963;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mitochondrial RNA modification#GO:1900864;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG189175|UniProtKB=T1FQR2 T1FQR2 20211159 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG116111|UniProtKB=T1EGD1 T1EGD1 20195633 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268 signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG185319|UniProtKB=T1FMN6 T1FMN6 20210085 PTHR12277:SF72 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN BAT5L PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;glycerolipid metabolic process#GO:0046486;glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerophospholipid catabolic process#GO:0046475 serine protease#PC00203 HELRO|EnsemblGenome=HelroG175980|UniProtKB=T1F9Z8 T1F9Z8 20205647 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84621|UniProtKB=T1G5L0 T1G5L0 20216357 PTHR24072:SF399 RHO FAMILY GTPASE AT17867P hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;protein binding#GO:0005515;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553 neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of anatomical structure morphogenesis#GO:0022603;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;cell development#GO:0048468;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;actin filament organization#GO:0007015;neurogenesis#GO:0022008;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;establishment or maintenance of cell polarity#GO:0007163;generation of neurons#GO:0048699;Rac protein signal transduction#GO:0016601;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;cell projection organization#GO:0030030;cell differentiation#GO:0030154;signaling#GO:0023052;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;cellular developmental process#GO:0048869;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;cortical cytoskeleton organization#GO:0030865;regulation of cell motility#GO:2000145;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;system development#GO:0048731;intracellular signal transduction#GO:0035556;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of developmental process#GO:0050793 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 G-protein#PC00020;small GTPase#PC00208 Huntington disease#P00029>Rac#P00775;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG103700|UniProtKB=T1EDG9 T1EDG9 20194621 PTHR24089:SF769 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SCAMC transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;localization#GO:0051179;establishment of localization#GO:0051234;carbohydrate derivative transport#GO:1901264;transport#GO:0006810;nitrogen compound transport#GO:0071705 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG186139|UniProtKB=T1FNQ0 T1FNQ0 20210447 PTHR19375:SF582 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787 metabolic process#GO:0008152;protein refolding#GO:0042026;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Hsp70 family chaperone#PC00027;chaperone#PC00072 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG83432|UniProtKB=T1G555 T1G555 20216203 PTHR12787:SF0 RIBOSOMAL RNA-PROCESSING PROTEIN 8 RIBOSOMAL RNA-PROCESSING PROTEIN 8 catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;nucleolus organization#GO:0007000;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;nucleus organization#GO:0006997;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186175|UniProtKB=T1FNR8 T1FNR8 20210465 PTHR11726:SF10 60S RIBOSOMAL PROTEIN L10 LARGE RIBOSOMAL SUBUNIT PROTEIN UL16 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG111699|UniProtKB=T1EFD8 T1EFD8 20195290 PTHR45754:SF3 METHYLENETETRAHYDROFOLATE REDUCTASE METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH) binding#GO:0005488;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 tetrahydrofolate biosynthetic process#GO:0046654;oxoacid metabolic process#GO:0043436;tetrahydrofolate metabolic process#GO:0046653;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;proteinogenic amino acid biosynthetic process#GO:0170038;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;sulfur compound metabolic process#GO:0006790;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 reductase#PC00198 HELRO|EnsemblGenome=HelroG167651|UniProtKB=T1EZM4 T1EZM4 20202024 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169691|UniProtKB=T1F285 T1F285 20202935 PTHR21683:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 42 HOMOLOG ISOFORM X1 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG166577|UniProtKB=T1EY97 T1EY97 20201547 PTHR45961:SF6 IP21249P IP21249P phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG165732|UniProtKB=T1EX80 T1EX80 20201180 PTHR46459:SF1 E1A-BINDING PROTEIN P400-RELATED E1A-BINDING PROTEIN P400 chromatin binding#GO:0003682;binding#GO:0005488 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;Swr1 complex#GO:0000812;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;H4 histone acetyltransferase complex#GO:1902562;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;acetyltransferase complex#GO:1902493;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG67291|UniProtKB=T1FYZ3 T1FYZ3 20214041 PTHR11165:SF24 SKP1 S-PHASE KINASE-ASSOCIATED PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171733|UniProtKB=T1F4L3 T1F4L3 20203762 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77755|UniProtKB=T1G335 T1G335 20215483 PTHR21255:SF7 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;organelle#GO:0043226;dynein complex#GO:0030286;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG173517|UniProtKB=T1F6X3 T1F6X3 20204572 PTHR46449:SF5 ZGC:158260 FAMILY WITH SEQUENCE SIMILARITY 47 MEMBER E primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of biosynthetic process#GO:0009891;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription by RNA polymerase II#GO:0006366;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;transcription initiation at RNA polymerase II promoter#GO:0006367;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription initiation-coupled chromatin remodeling#GO:0045815;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG94727|UniProtKB=T1G925 T1G925 20217572 PTHR46492:SF1 DYNEIN ASSEMBLY FACTOR 4, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 4 microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cilium movement#GO:0003341;inner dynein arm assembly#GO:0036159;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031 chaperone#PC00072 HELRO|EnsemblGenome=HelroG190088|UniProtKB=T1FRP1 T1FRP1 20211488 PTHR15351:SF6 ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG ERLIN macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to chemical#GO:0042221;biological regulation#GO:0065007;SREBP signaling pathway#GO:0032933;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;catabolic process#GO:0009056;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG109845|UniProtKB=T1EEW8 T1EEW8 20195120 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023 positive regulation of cell population proliferation#GO:0008284;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;nervous system development#GO:0007399;neuron differentiation#GO:0030182;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;positive regulation of cellular process#GO:0048522;ERBB signaling pathway#GO:0038127;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG191692|UniProtKB=T1FT77 T1FT77 20212024 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG165937|UniProtKB=T1EXH3 T1EXH3 20201273 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 transferase complex#GO:1990234;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186050|UniProtKB=T1FNL6 T1FNL6 20210413 PTHR23122:SF69 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK FI17352P1 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175371|UniProtKB=T1F973 T1F973 20205372 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG137446|UniProtKB=T1EIK9 T1EIK9 20196409 PTHR44500:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184006|UniProtKB=T1FKE7 T1FKE7 20209296 PTHR31761:SF1 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1 LARGE RIBOSOMAL SUBUNIT PROTEIN ML64 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG177428|UniProtKB=T1FBP2 T1FBP2 20206241 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62849|UniProtKB=T1FX62 T1FX62 20213410 PTHR11132:SF250 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E3 antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG180182|UniProtKB=T1FFJ8 T1FFJ8 20207597 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG98272|UniProtKB=T1G9L6 T1G9L6 20217762 PTHR15172:SF1 GALACTOCEREBROSIDASE GALACTOCEREBROSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;carbohydrate derivative catabolic process#GO:1901136;glycolipid metabolic process#GO:0006664;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764 galactosidase#PC00104;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG77232|UniProtKB=T1G2U8 T1G2U8 20215396 PTHR45787:SF1 LD11652P BEADEX, ISOFORM D transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG156927|UniProtKB=T1EM34 T1EM34 20197634 PTHR11801:SF70 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cell surface receptor signaling pathway via STAT#GO:0097696;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;defense response#GO:0006952;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173 HELRO|EnsemblGenome=HelroG194032|UniProtKB=T1FVL3 T1FVL3 20212859 PTHR12942:SF2 STEP II SPLICING FACTOR SLU7 PRE-MRNA-SPLICING FACTOR SLU7 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;pre-mRNA binding#GO:0036002 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG82086|UniProtKB=T1G4M6 T1G4M6 20216024 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515 positive regulation of vesicle fusion#GO:0031340;exocytosis#GO:0006887;regulation of transport#GO:0051049;regulation of localization#GO:0032879;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;synaptic signaling#GO:0099536;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;export from cell#GO:0140352;signaling#GO:0023052;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;regulation of exocytosis#GO:0017157;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;organelle membrane#GO:0031090;plasma membrane#GO:0005886;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG173907|UniProtKB=T1F7C8 T1F7C8 20204727 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169285|UniProtKB=T1F1Q3 T1F1Q3 20202753 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165544|UniProtKB=T1EWZ9 T1EWZ9 20201099 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG193523|UniProtKB=T1FV28 T1FV28 20212674 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;macromolecule metabolic process#GO:0043170;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG167891|UniProtKB=T1EZX5 T1EZX5 20202125 PTHR13510:SF44 FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED RABENOSYN-5 HELRO|EnsemblGenome=HelroG170768|UniProtKB=T1F3E4 T1F3E4 20203343 PTHR15117:SF24 ATAXIN 7 RELATED ATAXIN-7-LIKE PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 HELRO|EnsemblGenome=HelroG194308|UniProtKB=T1FVX0 T1FVX0 20212966 PTHR46531:SF1 ZINC TRANSPORTER 6 ZINC TRANSPORTER 6 transport#GO:0006810;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;metal ion transport#GO:0030001;zinc ion transport#GO:0006829 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG188890|UniProtKB=T1FQG1 T1FQG1 20211058 PTHR13866:SF29 SPARC OSTEONECTIN FOLLISTATIN ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG108581|UniProtKB=T1EEK5 T1EEK5 20195007 PTHR45929:SF3 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosome transport via multivesicular body sorting pathway#GO:0032509;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;macromolecule localization#GO:0033036;localization#GO:0051179;protein metabolic process#GO:0019538;protein localization to vacuole#GO:0072665;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;endosomal transport#GO:0016197;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein transport#GO:0015031;cellular localization#GO:0051641;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization to vacuole#GO:0072666 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189614|UniProtKB=T1FR74 T1FR74 20211321 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787 regulation of RNA stability#GO:0043487;RNA decapping#GO:0110154;regulation of RNA metabolic process#GO:0051252;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG166124|UniProtKB=T1EXT6 T1EXT6 20201386 PTHR24418:SF162 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG161850|UniProtKB=T1ERY8 T1ERY8 20199338 PTHR21349:SF0 50S RIBOSOMAL PROTEIN L21 LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;mitochondrial translation#GO:0032543 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739 ribosomal protein#PC00202 Methylcitrate cycle#P02754>Aconitase#P03028 HELRO|EnsemblGenome=HelroG168163|UniProtKB=T1F091 T1F091 20202241 PTHR44472:SF5 DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 4 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG86903|UniProtKB=T1G6J0 T1G6J0 20216687 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;intracellular signal transduction#GO:0035556;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185506|UniProtKB=T1FMW7 T1FMW7 20210166 PTHR10606:SF44 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM phosphoric ester hydrolase activity#GO:0042578;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787;sugar-phosphatase activity#GO:0050308 metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 hydrolase#PC00121;carbohydrate phosphatase#PC00066;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG190145|UniProtKB=T1FRQ6 T1FRQ6 20211503 PTHR14689:SF2 PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166413|UniProtKB=T1EY39 T1EY39 20201489 PTHR13144:SF0 TEX261 PROTEIN PROTEIN TEX261 cargo receptor activity#GO:0038024 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG176350|UniProtKB=T1FAF1 T1FAF1 20205800 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172409|UniProtKB=T1F5A3 T1F5A3 20204002 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cell-substrate adhesion#GO:0031589;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cellular process#GO:0009987 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG90849|UniProtKB=T1G7X0 T1G7X0 20217167 PTHR12027:SF91 WNT RELATED PROTO-ONCOGENE WNT-1 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677 cell fate commitment#GO:0045165;system development#GO:0048731;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HELRO|EnsemblGenome=HelroG180146|UniProtKB=T1FFI6 T1FFI6 20207585 PTHR12011:SF481 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG100634|UniProtKB=T1ED09 T1ED09 20194461 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG172160|UniProtKB=T1F533 T1F533 20203932 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG173035|UniProtKB=T1F6A4 T1F6A4 20204353 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190503|UniProtKB=T1FS18 T1FS18 20211615 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;N-acetyltransferase activity#GO:0008080;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186 HELRO|EnsemblGenome=HelroG185163|UniProtKB=T1FMG6 T1FMG6 20210015 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG72429|UniProtKB=T1G0Z9 T1G0Z9 20214747 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;steroid hydroxylase activity#GO:0008395;binding#GO:0005488;tetrapyrrole binding#GO:0046906 cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to chemical#GO:0042221;steroid metabolic process#GO:0008202;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805 intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG105263|UniProtKB=T1EDS6 T1EDS6 20194728 PTHR11610:SF199 LIPASE PANCREATIC TRIACYLGLYCEROL LIPASE-LIKE ISOFORM X2 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 catabolic process#GO:0009056;lipid metabolic process#GO:0006629;cellular process#GO:0009987;lipid catabolic process#GO:0016042;primary metabolic process#GO:0044238;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG102572|UniProtKB=T1EDA5 T1EDA5 20194557 PTHR24361:SF433 MITOGEN-ACTIVATED KINASE KINASE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HELRO|EnsemblGenome=HelroG179325|UniProtKB=T1FEJ8 T1FEJ8 20207247 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106036|UniProtKB=T1EDZ4 T1EDZ4 20194796 PTHR12801:SF115 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED FI18136P1-RELATED hydrolase activity, acting on ester bonds#GO:0016788;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 exoribonuclease#PC00099;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG78384|UniProtKB=T1G3B3 T1G3B3 20215561 PTHR24416:SF634 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;collagen binding#GO:0005518;binding#GO:0005488;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023 regulation of intracellular signal transduction#GO:1902531;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of intracellular signal transduction#GO:1902533;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169185|UniProtKB=T1F1J5 T1F1J5 20202695 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;DNA exonuclease activity#GO:0004529;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG175512|UniProtKB=T1F9C5 T1F9C5 20205424 PTHR20875:SF0 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED GH12158P calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG162998|UniProtKB=T1ETJ0 T1ETJ0 20199890 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160833|UniProtKB=T1EQS7 T1EQS7 20198927 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG92925|UniProtKB=T1G8N9 T1G8N9 20217436 PTHR11537:SF294 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;synaptic membrane#GO:0097060;protein-containing complex#GO:0032991;cell leading edge#GO:0031252;neuron projection#GO:0043005;presynapse#GO:0098793;cell projection membrane#GO:0031253;postsynaptic membrane#GO:0045211;leading edge membrane#GO:0031256;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;postsynapse#GO:0098794;cell body#GO:0044297;axon terminus#GO:0043679;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;membrane#GO:0016020;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;dendrite#GO:0030425;dendritic tree#GO:0097447;axon#GO:0030424;neuron projection terminus#GO:0044306;neuronal cell body#GO:0043025;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG110111|UniProtKB=T1EEZ2 T1EEZ2 20195144 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG76907|UniProtKB=T1G2Q9 T1G2Q9 20215357 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG185973|UniProtKB=T1FNI1 T1FNI1 20210378 PTHR24067:SF392 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755 catabolic process#GO:0009056;response to stimulus#GO:0050896;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057 membraneless organelle#GO:0043228;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG158657|UniProtKB=T1EN35 T1EN35 20197985 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185092|UniProtKB=T1FMD9 T1FMD9 20209988 PTHR47977:SF128 RAS-RELATED PROTEIN RAB LD21953P hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456 membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG164456|UniProtKB=T1EVF8 T1EVF8 20200558 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG190926|UniProtKB=T1FSF4 T1FSF4 20211751 PTHR13268:SF0 BREAST CARCINOMA AMPLIFIED SEQUENCE 3 BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;response to stress#GO:0006950;cellular component organization#GO:0016043;response to nutrient levels#GO:0031667;response to starvation#GO:0042594;organelle organization#GO:0006996;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;response to stimulus#GO:0050896;catabolic process#GO:0009056;macroautophagy#GO:0016236 phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG173599|UniProtKB=T1F705 T1F705 20204604 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;late endosome membrane#GO:0031902;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008 HELRO|EnsemblGenome=HelroG159623|UniProtKB=T1EP92 T1EP92 20198392 PTHR23024:SF574 ARYLACETAMIDE DEACETYLASE KYNURENINE FORMAMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;indole-containing compound metabolic process#GO:0042430;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 deacetylase#PC00087 HELRO|EnsemblGenome=HelroG193727|UniProtKB=T1FVA7 T1FVA7 20212753 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184607|UniProtKB=T1FLK7 T1FLK7 20209706 PTHR21207:SF2 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED GH16267P-RELATED protein binding#GO:0005515;Hsp70 protein binding#GO:0030544;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879 HELRO|EnsemblGenome=HelroG190063|UniProtKB=T1FRN0 T1FRN0 20211477 PTHR22948:SF84 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;male gamete generation#GO:0048232;regionalization#GO:0003002;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cell maturation#GO:0048469;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;pattern specification process#GO:0007389;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;cellular process#GO:0009987;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;embryonic pattern specification#GO:0009880;embryo development#GO:0009790;oogenesis#GO:0048477;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound biosynthetic process#GO:0034654;anterior/posterior pattern specification#GO:0009952;metabolic process#GO:0008152;anterior/posterior axis specification#GO:0009948;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;cell differentiation#GO:0030154;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176967|UniProtKB=T1FB29 T1FB29 20206028 PTHR10760:SF18 TORSIN LD13476P-RELATED response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;response to stress#GO:0006950;response to misfolded protein#GO:0051788;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to topologically incorrect protein#GO:0035967;cellular response to misfolded protein#GO:0071218;cellular response to stress#GO:0033554 chaperone#PC00072 Parkinson disease#P00049>Torsin A#P01221 HELRO|EnsemblGenome=HelroG64205|UniProtKB=T1FXR4 T1FXR4 20213612 PTHR19980:SF0 RNA CLEAVAGE STIMULATION FACTOR CLEAVAGE STIMULATION FACTOR SUBUNIT 3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG114508|UniProtKB=T1EG22 T1EG22 20195524 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG184232|UniProtKB=T1FKT3 T1FKT3 20209432 PTHR12241:SF161 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879 microtubule bundle formation#GO:0001578;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG189079|UniProtKB=T1FQM3 T1FQM3 20211120 PTHR23257:SF998 SERINE-THREONINE PROTEIN KINASE AT08303P phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG169381|UniProtKB=T1F1V6 T1F1V6 20202806 PTHR34153:SF3 SI:CH211-262H13.3-RELATED-RELATED SI:CH211-262H13.3 HELRO|EnsemblGenome=HelroG190440|UniProtKB=T1FRZ9 T1FRZ9 20211596 PTHR43272:SF111 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;long-chain fatty acid metabolic process#GO:0001676;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;oxoacid metabolic process#GO:0043436;generation of neurons#GO:0048699;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;lipid droplet#GO:0005811;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 ligase#PC00142 HELRO|EnsemblGenome=HelroG77588|UniProtKB=T1G303 T1G303 20215451 PTHR45791:SF1 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;magnesium ion binding#GO:0000287;cation binding#GO:0043169;metal ion binding#GO:0046872 HELRO|EnsemblGenome=HelroG170138|UniProtKB=T1F2P5 T1F2P5 20203094 PTHR46607:SF1 SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1 SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1 phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094 HELRO|EnsemblGenome=HelroG74931|UniProtKB=T1G1Y0 T1G1Y0 20215078 PTHR21451:SF0 HISTONE H3 METHYLTRANSFERASE HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;heterochromatin formation#GO:0031507;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;chromatin organization#GO:0006325;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;DNA damage checkpoint signaling#GO:0000077;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;DNA integrity checkpoint signaling#GO:0031570;cellular response to stress#GO:0033554;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;constitutive heterochromatin formation#GO:0140719;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;heterochromatin organization#GO:0070828;regulation of cell cycle process#GO:0010564;cellular component assembly#GO:0022607;cell cycle checkpoint signaling#GO:0000075;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG65492|UniProtKB=T1FY86 T1FY86 20213784 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG193984|UniProtKB=T1FVJ4 T1FVJ4 20212840 PTHR45678:SF5 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED MITOCHONDRIAL GLUTAMATE CARRIER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185895|UniProtKB=T1FNE8 T1FNE8 20210345 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG186271|UniProtKB=T1FNW2 T1FNW2 20210509 PTHR43721:SF36 ELONGATION FACTOR TU-RELATED ELONGATION FACTOR TU, MITOCHONDRIAL translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;translational elongation#GO:0006414 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG157793|UniProtKB=T1EMF9 T1EMF9 20197759 PTHR10217:SF642 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG73506|UniProtKB=T1G1E9 T1G1E9 20214897 PTHR24366:SF170 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS ELRR (EXTRACELLULAR LEUCINE-RICH REPEAT) ONLY immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG72925|UniProtKB=T1G173 T1G173 20214821 PTHR24248:SF199 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG159716|UniProtKB=T1EPC3 T1EPC3 20198423 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG193980|UniProtKB=T1FVJ2 T1FVJ2 20212838 PTHR43580:SF10 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491 chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366 chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG170433|UniProtKB=T1F321 T1F321 20203220 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE MGP4 glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG174354|UniProtKB=T1F816 T1F816 20204965 PTHR22948:SF83 TUDOR DOMAIN CONTAINING PROTEIN TUDOR AND KH DOMAIN-CONTAINING PROTEIN HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG138545|UniProtKB=T1EIV4 T1EIV4 20196504 PTHR13864:SF10 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG166545|UniProtKB=T1EY82 T1EY82 20201532 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG153321|UniProtKB=T1EL38 T1EL38 20197288 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144657|UniProtKB=T1EJF5 T1EJF5 20196705 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG109396|UniProtKB=T1EET2 T1EET2 20195084 PTHR24014:SF6 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL RNA binding#GO:0003723;tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;binding#GO:0005488 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;tRNA 3'-end processing#GO:0042780;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA 3'-end processing#GO:0031123;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;mitochondrial RNA modification#GO:1900864;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164275|UniProtKB=T1EV70 T1EV70 20200470 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG74572|UniProtKB=T1G1T0 T1G1T0 20215028 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194583|UniProtKB=T1FW79 T1FW79 20213075 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG164189|UniProtKB=T1EV28 T1EV28 20200428 PTHR19860:SF42 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED DUF4062 DOMAIN-CONTAINING PROTEIN transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG171529|UniProtKB=T1F4D8 T1F4D8 20203687 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG86882|UniProtKB=T1G6I7 T1G6I7 20216684 PTHR14499:SF148 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING GH08630P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174564|UniProtKB=T1F894 T1F894 20205043 PTHR24366:SF174 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS IG-LIKE DOMAIN-CONTAINING PROTEIN immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG177056|UniProtKB=T1FB67 T1FB67 20206066 PTHR12281:SF31 RP42 RELATED DCN1-LIKE PROTEIN 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;binding#GO:0005488;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;regulation of protein modification process#GO:0031399;positive regulation of protein metabolic process#GO:0051247 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155705|UniProtKB=T1ELL0 T1ELL0 20197460 PTHR11624:SF116 DEHYDROGENASE RELATED PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;pyruvate metabolic process#GO:0006090;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;acetyl-CoA metabolic process#GO:0006084;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980 protein-containing complex#GO:0032991;acetyltransferase complex#GO:1902493;oxidoreductase complex#GO:1990204;catalytic complex#GO:1902494;transferase complex#GO:1990234 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG156685|UniProtKB=T1EM00 T1EM00 20197600 PTHR43108:SF16 N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER EXTRACELLULAR SULFATASE SULF-1 HOMOLOG catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 carbohydrate derivative catabolic process#GO:1901136;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of cytokine production#GO:0001819;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;positive regulation of biosynthetic process#GO:0009891;protein metabolic process#GO:0019538;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;positive regulation of cellular process#GO:0048522;carbohydrate derivative metabolic process#GO:1901135;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of Wnt signaling pathway#GO:0030111;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of signaling#GO:0023056;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;negative regulation of signal transduction#GO:0009968;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;proteoglycan metabolic process#GO:0006029;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG158532|UniProtKB=T1EMX4 T1EMX4 20197924 PTHR23192:SF92 OLFACTOMEDIN-RELATED FI21454P1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HELRO|EnsemblGenome=HelroG185918|UniProtKB=T1FNF8 T1FNF8 20210355 PTHR10802:SF2 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 HOMOLOG 1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transmembrane protein transporter activity#GO:0008320 protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;mitochondrial transmembrane transport#GO:1990542;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane translocase complex#GO:0005742;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG176430|UniProtKB=T1FAI0 T1FAI0 20205829 PTHR43979:SF1 PRE-MRNA-PROCESSING FACTOR 17 PRE-MRNA-PROCESSING FACTOR 17 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG180908|UniProtKB=T1FGE5 T1FGE5 20207894 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG77345|UniProtKB=T1G2W6 T1G2W6 20215414 PTHR10134:SF50 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;electron transport chain#GO:0022900 catalytic complex#GO:1902494;respiratory chain complex III#GO:0045275;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG89022|UniProtKB=T1G781 T1G781 20216928 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG185199|UniProtKB=T1FMI0 T1FMI0 20210029 PTHR22846:SF2 WD40 REPEAT PROTEIN F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transcription repressor complex#GO:0017053;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233 Wnt signaling pathway#P00057>Ebi#P01453 HELRO|EnsemblGenome=HelroG105915|UniProtKB=T1EDY7 T1EDY7 20194789 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG151577|UniProtKB=T1EKL2 T1EKL2 20197112 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG173429|UniProtKB=T1F6T5 T1F6T5 20204534 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG125208|UniProtKB=T1EH50 T1EH50 20195900 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG168487|UniProtKB=T1F0M5 T1F0M5 20202375 PTHR33844:SF1 SULFOTRANSFER_1 DOMAIN-CONTAINING PROTEIN SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172075|UniProtKB=T1F501 T1F501 20203900 PTHR19818:SF178 ZINC FINGER PROTEIN ZIC AND GLI PAIR-RULE PROTEIN ODD-PAIRED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG81180|UniProtKB=T1G4A7 T1G4A7 20215905 PTHR46152:SF3 NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 HELRO|EnsemblGenome=HelroG163051|UniProtKB=T1ETL8 T1ETL8 20199918 PTHR12289:SF41 METAXIN RELATED METAXIN-1 HOMOLOG localization#GO:0051179;cellular localization#GO:0051641;protein insertion into mitochondrial outer membrane#GO:0045040;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein localization to mitochondrion#GO:0070585;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;cellular process#GO:0009987 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane translocase complex#GO:0005742;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrial protein-containing complex#GO:0098798;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 transporter#PC00227 HELRO|EnsemblGenome=HelroG86707|UniProtKB=T1G6F8 T1G6F8 20216655 PTHR24104:SF51 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189566|UniProtKB=T1FR58 T1FR58 20211305 PTHR10582:SF28 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN NANCHUNG, ISOFORM B calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;calcium ion import#GO:0070509;calcium ion transmembrane transport#GO:0070588;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG87913|UniProtKB=T1G6W8 T1G6W8 20216815 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG157054|UniProtKB=T1EM55 T1EM55 20197655 PTHR13292:SF0 AUTOPHAGY-RELATED PROTEIN 101 AUTOPHAGY-RELATED PROTEIN 101 protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 organelle assembly#GO:0070925;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component organization or biogenesis#GO:0071840;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG192909|UniProtKB=T1FUF1 T1FUF1 20212447 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG189099|UniProtKB=T1FQN1 T1FQN1 20211128 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG157365|UniProtKB=T1EMA3 T1EMA3 20197703 PTHR23430:SF7 HISTONE H2A HISTONE H2A.V structural molecule activity#GO:0005198 negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG179230|UniProtKB=T1FEE2 T1FEE2 20207191 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG167080|UniProtKB=T1EYZ9 T1EYZ9 20201799 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272 sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG173408|UniProtKB=T1F6S4 T1F6S4 20204523 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160039|UniProtKB=T1EPP8 T1EPP8 20198548 PTHR11801:SF67 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SUBFAMILY NOT NAMED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG177763|UniProtKB=T1FC76 T1FC76 20206425 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG63503|UniProtKB=T1FXG6 T1FXG6 20213514 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG194422|UniProtKB=T1FW14 T1FW14 20213010 PTHR24412:SF172 KELCH PROTEIN KELCH-LIKE PROTEIN 10 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;transferase complex#GO:1990234;catalytic complex#GO:1902494;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185582|UniProtKB=T1FN03 T1FN03 20210202 PTHR13313:SF0 CYTOCHROME C OXIDASE SUBUNIT VIIC CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;transporter complex#GO:1990351;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxidase#PC00175 HELRO|EnsemblGenome=HelroG69957|UniProtKB=T1G005 T1G005 20214403 PTHR46374:SF1 PROTEIN CBG07384 START DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG141954|UniProtKB=T1EJ46 T1EJ46 20196596 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 system development#GO:0048731;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cell communication#GO:0007154;anatomical structure development#GO:0048856;localization within membrane#GO:0051668;establishment or maintenance of bipolar cell polarity#GO:0061245;protein localization to cell junction#GO:1902414;establishment or maintenance of apical/basal cell polarity#GO:0035088;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;intracellular protein localization#GO:0008104;developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;receptor clustering#GO:0043113;cell adhesion#GO:0007155;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;nervous system development#GO:0007399;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell adhesion#GO:0098609 postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;cell junction#GO:0030054;neuromuscular junction#GO:0031594;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188060|UniProtKB=T1FPL2 T1FPL2 20210759 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG161469|UniProtKB=T1ERI1 T1ERI1 20199181 PTHR15093:SF1 PROSTATE APOPTOSIS RESPONSE PROTEIN PAR-4 PRKC APOPTOSIS WT1 REGULATOR PROTEIN positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;apoptotic signaling pathway#GO:0097190;regulation of neuron apoptotic process#GO:0043523;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;cell communication#GO:0007154;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell death#GO:0008219;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG153470|UniProtKB=T1EL78 T1EL78 20197328 PTHR13864:SF10 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG194331|UniProtKB=T1FVY1 T1FVY1 20212977 PTHR15495:SF7 NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED GPI INOSITOL-DEACYLASE deacylase activity#GO:0160215;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 transporter#PC00227 HELRO|EnsemblGenome=HelroG159677|UniProtKB=T1EPA8 T1EPA8 20198408 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69340|UniProtKB=T1FZT4 T1FZT4 20214332 PTHR24346:SF45 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SNF-RELATED SERINE_THREONINE-PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105468|UniProtKB=T1EDV1 T1EDV1 20194753 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG90889|UniProtKB=T1G7X4 T1G7X4 20217171 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G symporter activity#GO:0015293;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;chloride transmembrane transporter activity#GO:0015108;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG159754|UniProtKB=T1EPD1 T1EPD1 20198431 PTHR46780:SF21 PROTEIN EVA-1 D-GALACTOSIDE-SPECIFIC LECTIN ISOFORM X1-RELATED HELRO|EnsemblGenome=HelroG172679|UniProtKB=T1F5S0 T1F5S0 20204169 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194424|UniProtKB=T1FW16 T1FW16 20213012 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170742|UniProtKB=T1F3D6 T1F3D6 20203335 PTHR10749:SF7 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG66185|UniProtKB=T1FYI2 T1FYI2 20213880 PTHR10721:SF1 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;protein transport#GO:0015031 membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;organelle lumen#GO:0043233;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG86877|UniProtKB=T1G6I6 T1G6I6 20216683 PTHR11661:SF48 60S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M structural molecule activity#GO:0005198;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;rRNA binding#GO:0019843;binding#GO:0005488 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG165006|UniProtKB=T1EW41 T1EW41 20200791 PTHR45749:SF43 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1-LIKE HELRO|EnsemblGenome=HelroG105471|UniProtKB=T1EDV2 T1EDV2 20194754 PTHR48078:SF2 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED CATABOLIC L-SERINE_THREONINE DEHYDRATASE catalytic activity#GO:0003824;lyase activity#GO:0016829 cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;aspartate family amino acid biosynthetic process#GO:0009067;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;branched-chain amino acid biosynthetic process#GO:0009082;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG157419|UniProtKB=T1EMB3 T1EMB3 20197713 PTHR13768:SF8 SOLUBLE NSF ATTACHMENT PROTEIN SNAP ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein transport#GO:0015031;localization#GO:0051179;cellular component disassembly#GO:0022411;cellular localization#GO:0051641;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG171587|UniProtKB=T1F4F6 T1F4F6 20203705 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86626|UniProtKB=T1G6E5 T1G6E5 20216642 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG120769|UniProtKB=T1EGQ6 T1EGQ6 20195756 PTHR19444:SF13 UNC-93 RELATED N-ACETYLGLUCOSAMINE TRANSPORTER UNC93A ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG124660|UniProtKB=T1EH24 T1EH24 20195874 PTHR31501:SF7 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 ion channel#PC00133 HELRO|EnsemblGenome=HelroG89498|UniProtKB=T1G7D7 T1G7D7 20216984 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG68929|UniProtKB=T1FZM0 T1FZM0 20214268 PTHR21319:SF53 RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 P53 pathway feedback loops 1#P04392>Pirh-2#G04684;P53 pathway feedback loops 1#P04392>Pirh-2#P04538 HELRO|EnsemblGenome=HelroG107832|UniProtKB=T1EED1 T1EED1 20194933 PTHR19134:SF553 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Axon guidance mediated by Slit/Robo#P00008>Ptp10D#P00343 HELRO|EnsemblGenome=HelroG193445|UniProtKB=T1FUZ7 T1FUZ7 20212643 PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;molecular carrier activity#GO:0140104;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;zinc ion binding#GO:0008270 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG181957|UniProtKB=T1FHI5 T1FHI5 20208284 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG171241|UniProtKB=T1F3Z5 T1F3Z5 20203544 PTHR14058:SF8 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B PROTEIN FE65 HOMOLOG binding#GO:0005488;peptide binding#GO:0042277 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG163538|UniProtKB=T1EU61 T1EU61 20200111 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG114138|UniProtKB=T1EFZ5 T1EFZ5 20195497 PTHR10876:SF7 ZINC FINGER PROTEIN ZPR1 ZINC FINGER PROTEIN ZPR1 protein binding#GO:0005515;binding#GO:0005488 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nuclear body#GO:0016604;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080 HELRO|EnsemblGenome=HelroG100409|UniProtKB=T1ECZ6 T1ECZ6 20194448 PTHR13104:SF0 MED-6-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 6 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG74564|UniProtKB=T1G1S8 T1G1S8 20215026 PTHR10625:SF23 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 11 histone deacetylase activity#GO:0004407;deacylase activity#GO:0160215;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG172632|UniProtKB=T1F5P1 T1F5P1 20204140 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG191188|UniProtKB=T1FSQ4 T1FSQ4 20211851 PTHR23198:SF6 NUCLEOPORIN NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96 nucleic acid binding#GO:0003676;binding#GO:0005488;structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;RNA binding#GO:0003723 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;establishment of RNA localization#GO:0051236;protein localization to organelle#GO:0033365;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;telomere localization#GO:0034397;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;organelle localization#GO:0051640;chromosome localization#GO:0050000;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;cellular component organization#GO:0016043;protein import into nucleus#GO:0006606;protein transport#GO:0015031;cellular localization#GO:0051641;telomere tethering at nuclear periphery#GO:0034398 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643 transporter#PC00227 HELRO|EnsemblGenome=HelroG183435|UniProtKB=T1FJN2 T1FJN2 20209031 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178148|UniProtKB=T1FCU4 T1FCU4 20206643 PTHR24418:SF162 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG180531|UniProtKB=T1FG11 T1FG11 20207760 PTHR16021:SF28 MANSC DOMAIN CONTAINING PROTEIN 1 OXIDANT-INDUCED CELL-CYCLE ARREST PROTEIN 5 HELRO|EnsemblGenome=HelroG64552|UniProtKB=T1FXW4 T1FXW4 20213662 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594 cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG192665|UniProtKB=T1FU63 T1FU63 20212359 PTHR12858:SF2 RIBOSOME BIOGENESIS PROTEIN RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG RNA binding#GO:0003723;hydrolase activity#GO:0016787;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleic acid binding#GO:0003676;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;90S preribosome#GO:0030686;small-subunit processome#GO:0032040;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG70378|UniProtKB=T1G058 T1G058 20214456 PTHR18929:SF132 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stress#GO:0006950;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG86578|UniProtKB=T1G6E3 T1G6E3 20216640 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG64110|UniProtKB=T1FXP4 T1FXP4 20213592 PTHR10648:SF38 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 chromosome segregation#GO:0007059;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;sister chromatid cohesion#GO:0007062;cell cycle process#GO:0022402;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG177965|UniProtKB=T1FCJ1 T1FCJ1 20206540 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG193682|UniProtKB=T1FV92 T1FV92 20212738 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;nucleotide metabolic process#GO:0009117;regulation of cellular response to stress#GO:0080135;ribonucleotide metabolic process#GO:0009259;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleotide-sugar metabolic process#GO:0009225;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;regulation of response to stress#GO:0080134;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG167925|UniProtKB=T1EZY9 T1EZY9 20202139 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG186290|UniProtKB=T1FNX6 T1FNX6 20210523 PTHR11955:SF135 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, MUSCLE organic acid binding#GO:0043177;ion binding#GO:0043167;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;lipid binding#GO:0008289;fatty acid binding#GO:0005504 macromolecule localization#GO:0033036;lipid transport#GO:0006869;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;fatty acid transport#GO:0015908;establishment of localization#GO:0051234 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG66031|UniProtKB=T1FYG1 T1FYG1 20213859 PTHR15730:SF8 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED TRPM8 CHANNEL-ASSOCIATED FACTOR HOMOLOG-RELATED binding#GO:0005488;transmembrane transporter binding#GO:0044325;protein binding#GO:0005515 regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of localization#GO:0032879 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG85494|UniProtKB=T1G5Y0 T1G5Y0 20216477 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194990|UniProtKB=T1FWM6 T1FWM6 20213221 PTHR45080:SF45 CONTACTIN 5 IP11255P transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell junction organization#GO:0034330;cellular process#GO:0009987;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;cellular component organization or biogenesis#GO:0071840;cell adhesion#GO:0007155;synapse organization#GO:0050808 axon#GO:0030424;membrane#GO:0016020;neuron projection#GO:0043005;cell body#GO:0044297;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG160736|UniProtKB=T1EQN4 T1EQN4 20198884 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG168380|UniProtKB=T1F0I5 T1F0I5 20202335 PTHR46652:SF7 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 42 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG65589|UniProtKB=T1FYA3 T1FYA3 20213801 PTHR13027:SF18 SAND PROTEIN-RELATED SWIM-TYPE DOMAIN-CONTAINING PROTEIN GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG158382|UniProtKB=T1EMQ7 T1EMQ7 20197857 PTHR45973:SF12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED DYNEIN REGULATORY COMPLEX SUBUNIT 3 cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG160849|UniProtKB=T1EQT7 T1EQT7 20198937 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG64253|UniProtKB=T1FXR8 T1FXR8 20213616 PTHR10157:SF44 DOPAMINE BETA HYDROXYLASE RELATED TYRAMINE BETA-HYDROXYLASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to alcohol#GO:0097305;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667 hydroxylase#PC00122 Dopamine receptor mediated signaling pathway#P05912>DBH#P05955;Adrenaline and noradrenaline biosynthesis#P00001>DBH#P00063 HELRO|EnsemblGenome=HelroG182344|UniProtKB=T1FI34 T1FI34 20208483 PTHR24345:SF89 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;membraneless organelle#GO:0043228;spindle#GO:0005819;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG89171|UniProtKB=T1G796 T1G796 20216943 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG87513|UniProtKB=T1G6R3 T1G6R3 20216760 PTHR24322:SF755 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG72007|UniProtKB=T1G0U0 T1G0U0 20214688 PTHR10769:SF3 40S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN ES28 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;ribosomal small subunit assembly#GO:0000028;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG109399|UniProtKB=T1EET3 T1EET3 20195085 PTHR13856:SF137 VHS DOMAIN CONTAINING PROTEIN FAMILY GH05942P clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG183433|UniProtKB=T1FJN1 T1FJN1 20209030 PTHR15493:SF9 F-BOX ONLY PROTEIN 5 AND 43 GH14043P molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857 regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of meiotic cell cycle#GO:0051445;regulation of biological process#GO:0050789;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;cell cycle#GO:0007049;mitotic cell cycle phase transition#GO:0044772;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of reproductive process#GO:2000241;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cell cycle G1/S phase transition#GO:0044843;regulation of mitotic nuclear division#GO:0007088;mitotic cell cycle process#GO:1903047;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle process#GO:0010948;G1/S transition of mitotic cell cycle#GO:0000082;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG72901|UniProtKB=T1G170 T1G170 20214818 PTHR14927:SF0 NUCLEOLAR PROTEIN 10 NUCLEOLAR PROTEIN 10 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654 small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG171453|UniProtKB=T1F4A9 T1F4A9 20203658 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG184517|UniProtKB=T1FLD6 T1FLD6 20209635 PTHR23512:SF5 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 LYSOSOMAL DIPEPTIDE TRANSPORTER MFSD1 ISOFORM X1 HELRO|EnsemblGenome=HelroG71626|UniProtKB=T1G0P3 T1G0P3 20214641 PTHR45638:SF7 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E ion channel#PC00133;ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG183217|UniProtKB=T1FJB8 T1FJB8 20208917 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG162420|UniProtKB=T1ESM6 T1ESM6 20199576 PTHR12318:SF0 TESTOSTERONE-REGULATED PROTEIN RP2 ACYL-COENZYME A DIPHOSPHATASE NUDT19 HELRO|EnsemblGenome=HelroG186151|UniProtKB=T1FNQ6 T1FNQ6 20210453 PTHR45635:SF14 ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED ADP_ATP TRANSLOCASE purine nucleotide transmembrane transporter activity#GO:0015216;active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505 cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;regulation of mitochondrial membrane permeability#GO:0046902;biological regulation#GO:0065007;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;regulation of membrane permeability#GO:0090559;transport#GO:0006810;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG188754|UniProtKB=T1FQB8 T1FQB8 20211015 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG130526|UniProtKB=T1EHU1 T1EHU1 20196141 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG149645|UniProtKB=T1EKD1 T1EKD1 20197031 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG164610|UniProtKB=T1EVM8 T1EVM8 20200628 PTHR10782:SF108 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN TONALLI, ISOFORM E acyltransferase activity#GO:0016746;SUMO transferase activity#GO:0019789;transcription regulator activity#GO:0140110;SUMO ligase activity#GO:0061665;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;molecular function inhibitor activity#GO:0140678;catalytic activity#GO:0003824;transferase activity#GO:0016740;transcription coregulator activity#GO:0003712;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755 regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;negative regulation of biological process#GO:0048519;regulation of transcription by RNA polymerase II#GO:0006357;metabolic process#GO:0008152;protein sumoylation#GO:0016925;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;post-translational protein modification#GO:0043687;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163115|UniProtKB=T1ETP0 T1ETP0 20199940 PTHR44086:SF15 THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3 transferase activity, transferring sulphur-containing groups#GO:0016782;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG190685|UniProtKB=T1FS73 T1FS73 20211670 PTHR13802:SF52 MUCIN 4-RELATED NIDOGEN-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG175726|UniProtKB=T1F9K9 T1F9K9 20205508 PTHR12449:SF22 DEATH DOMAIN-CONTAINING PROTEIN NUCLEOLAR PROTEIN 4-LIKE ISOFORM X1 HELRO|EnsemblGenome=HelroG62947|UniProtKB=T1FX82 T1FX82 20213430 PTHR11885:SF6 RIBOSOMAL PROTEIN S15P/S13E SMALL RIBOSOMAL SUBUNIT PROTEIN US15 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytosolic ribosome#GO:0022626;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;ribosome#GO:0005840;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG83065|UniProtKB=T1G4Z9 T1G4Z9 20216147 PTHR22984:SF29 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE PIM-1 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;positive regulation of intracellular signal transduction#GO:1902533;regulation of TORC1 signaling#GO:1903432;positive regulation of TORC1 signaling#GO:1904263;regulation of TOR signaling#GO:0032006;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;positive regulation of cellular process#GO:0048522;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182840|UniProtKB=T1FIU5 T1FIU5 20208744 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG116640|UniProtKB=T1EGG8 T1EGG8 20195670 PTHR46317:SF1 HYDROLASE OF PHP SUPERFAMILY-RELATED PROTEIN DEOXYRIBONUCLEASE TATDN3 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG88168|UniProtKB=T1G6Z3 T1G6Z3 20216840 PTHR12411:SF929 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN Z peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG194326|UniProtKB=T1FVX8 T1FVX8 20212974 PTHR21677:SF1 CRAMPED PROTEIN PROTEIN CRAMPED-LIKE binding#GO:0005488;chromatin binding#GO:0003682 multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;pattern specification process#GO:0007389;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185271|UniProtKB=T1FML2 T1FML2 20210061 PTHR11802:SF201 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE SERINE CARBOXYPEPTIDASE CTSA-1.1 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;serine hydrolase activity#GO:0017171;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 serine protease#PC00203 HELRO|EnsemblGenome=HelroG91744|UniProtKB=T1G883 T1G883 20217280 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG65716|UniProtKB=T1FYB8 T1FYB8 20213816 PTHR10891:SF989 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG108482|UniProtKB=T1EEJ5 T1EEJ5 20194997 PTHR11614:SF198 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 membrane#GO:0016020;cellular anatomical structure#GO:0110165 phospholipase#PC00186;lipase#PC00143 HELRO|EnsemblGenome=HelroG182600|UniProtKB=T1FIG1 T1FIG1 20208610 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181013|UniProtKB=T1FGJ0 T1FGJ0 20207939 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG81152|UniProtKB=T1G4A3 T1G4A3 20215901 PTHR14085:SF3 WD-REPEAT PROTEIN BING4 WD REPEAT-CONTAINING PROTEIN 46 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 organelle lumen#GO:0043233;small-subunit processome#GO:0032040;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG163957|UniProtKB=T1EUN7 T1EUN7 20200287 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG174703|UniProtKB=T1F8E0 T1F8E0 20205089 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG82775|UniProtKB=T1G4W3 T1G4W3 20216111 PTHR10605:SF65 HEPARAN SULFATE SULFOTRANSFERASE GH20068P transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG87165|UniProtKB=T1G6M6 T1G6M6 20216723 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG82432|UniProtKB=T1G4S1 T1G4S1 20216069 PTHR24171:SF15 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50-RELATED HELRO|EnsemblGenome=HelroG165179|UniProtKB=T1EWE1 T1EWE1 20200891 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72414|UniProtKB=T1G0Z7 T1G0Z7 20214745 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192019|UniProtKB=T1FTI4 T1FTI4 20212131 PTHR24416:SF611 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;Wnt-protein binding#GO:0017147;protein kinase activity#GO:0004672;transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;axon#GO:0030424;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185039|UniProtKB=T1FMB5 T1FMB5 20209964 PTHR11352:SF0 PROLIFERATING CELL NUCLEAR ANTIGEN DNA SLIDING CLAMP PCNA enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 response to stimulus#GO:0050896;DNA strand elongation involved in DNA replication#GO:0006271;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;mismatch repair#GO:0006298;DNA replication#GO:0006260;DNA-templated DNA replication#GO:0006261;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translesion synthesis#GO:0019985;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA polymerase processivity factor#PC00015 DNA replication#P00017>PCNA#P00534 HELRO|EnsemblGenome=HelroG110878|UniProtKB=T1EF60 T1EF60 20195212 PTHR11073:SF1 CALRETICULIN AND CALNEXIN CALNEXIN 14D-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein folding#GO:0006457;catabolic process#GO:0009056;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;biosynthetic process#GO:0009058;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;protein maturation#GO:0051604;gene expression#GO:0010467 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG188730|UniProtKB=T1FQB1 T1FQB1 20211008 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG177633|UniProtKB=T1FBZ1 T1FBZ1 20206340 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG182431|UniProtKB=T1FI66 T1FI66 20208515 PTHR45798:SF108 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109730|UniProtKB=T1EEW1 T1EEW1 20195113 PTHR24044:SF512 NOTCH LIGAND FAMILY MEMBER PROTEIN LIN-12 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Next#P01103;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120 HELRO|EnsemblGenome=HelroG182122|UniProtKB=T1FHS6 T1FHS6 20208375 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182092|UniProtKB=T1FHQ4 T1FHQ4 20208353 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191199|UniProtKB=T1FSQ7 T1FSQ7 20211854 PTHR13280:SF17 PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN KRUEPPEL TARGET AT 95D, ISOFORM A intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657 HELRO|EnsemblGenome=HelroG193864|UniProtKB=T1FVF4 T1FVF4 20212800 PTHR11947:SF20 PYRUVATE DEHYDROGENASE KINASE BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG159767|UniProtKB=T1EPD9 T1EPD9 20198439 PTHR21268:SF2 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5 GH23780P HELRO|EnsemblGenome=HelroG155963|UniProtKB=T1ELP9 T1ELP9 20197499 PTHR13528:SF3 39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG188706|UniProtKB=T1FQA1 T1FQA1 20210998 PTHR11771:SF153 LIPOXYGENASE LIPOXYGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid oxidation#GO:0034440;lipid modification#GO:0030258 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG175070|UniProtKB=T1F8T2 T1F8T2 20205231 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167810|UniProtKB=T1EZU1 T1EZU1 20202091 PTHR16207:SF11 SET DOMAIN-CONTAINING PROTEIN SET DOMAIN-CONTAINING PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG159649|UniProtKB=T1EPA0 T1EPA0 20198400 PTHR12608:SF1 TRANSMEMBRANE PROTEIN HTP-1 RELATED DIVALENT CATION_PROTON ANTIPORTER TMEM165-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;calcium ion transmembrane transporter activity#GO:0015085;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG136060|UniProtKB=T1EIB7 T1EIB7 20196317 PTHR11106:SF27 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED POLY [ADP-RIBOSE] POLYMERASE HELRO|EnsemblGenome=HelroG191469|UniProtKB=T1FT06 T1FT06 20211953 PTHR11567:SF211 ACID PHOSPHATASE-RELATED ACID PHOSPHATASE catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG169099|UniProtKB=T1F1E2 T1F1E2 20202642 PTHR13817:SF166 TITIN MYOMESIN AND MYOSIN BINDING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG88777|UniProtKB=T1G762 T1G762 20216909 PTHR11953:SF1 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT RRP46 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;snRNA 3'-end processing#GO:0034472;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;snRNA processing#GO:0016180;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;nuclear mRNA surveillance#GO:0071028;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;snRNA metabolic process#GO:0016073;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194840|UniProtKB=T1FWH0 T1FWH0 20213165 PTHR22684:SF0 NULP1-RELATED RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG68059|UniProtKB=T1FZ97 T1FZ97 20214145 PTHR12296:SF30 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN CRAG molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG80892|UniProtKB=T1G468 T1G468 20215866 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488 lipid metabolic process#GO:0006629;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG176457|UniProtKB=T1FAJ0 T1FAJ0 20205839 PTHR15741:SF25 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR MAX-LIKE PROTEIN X RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG162745|UniProtKB=T1ET27 T1ET27 20199727 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG180221|UniProtKB=T1FFL1 T1FFL1 20207610 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG189560|UniProtKB=T1FR56 T1FR56 20211303 PTHR47705:SF1 AGAP000321-PA WINGED HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191233|UniProtKB=T1FSR7 T1FSR7 20211864 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177479|UniProtKB=T1FBR6 T1FBR6 20206265 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69899|UniProtKB=T1FZZ4 T1FZZ4 20214392 PTHR13803:SF39 SEC24-RELATED PROTEIN SECRETORY 24AB, ISOFORM A zinc ion binding#GO:0008270;SNARE binding#GO:0000149;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 COPII-coated vesicle budding#GO:0090114;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization#GO:0016043;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024 vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;coated membrane#GO:0048475;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG71352|UniProtKB=T1G0K0 T1G0K0 20214598 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 TITIN-LIKE HELRO|EnsemblGenome=HelroG158625|UniProtKB=T1EN11 T1EN11 20197961 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157532|UniProtKB=T1EMC7 T1EMC7 20197727 PTHR11931:SF33 PHOSPHOGLYCERATE MUTASE PHOSPHOGLYCERATE MUTASE catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;intramolecular phosphotransferase activity#GO:0016868;isomerase activity#GO:0016853;phosphoglycerate mutase activity#GO:0004619 glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 mutase#PC00160;isomerase#PC00135 Glycolysis#P00024>Phosphoglyceromutase#P00680 HELRO|EnsemblGenome=HelroG81872|UniProtKB=T1G4K0 T1G4K0 20215998 PTHR24346:SF117 MAP/MICROTUBULE AFFINITY-REGULATING KINASE CAMK FAMILY PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155765|UniProtKB=T1ELM2 T1ELM2 20197472 PTHR13832:SF565 PROTEIN PHOSPHATASE 2C PROTEIN-SERINE_THREONINE PHOSPHATASE protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG188971|UniProtKB=T1FQI7 T1FQI7 20211084 PTHR45943:SF1 E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of cell junction assembly#GO:1901888;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of growth#GO:0040008;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;axon development#GO:0061564;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;regulation of synapse organization#GO:0050807;generation of neurons#GO:0048699;regulation of biological quality#GO:0065008;neuron development#GO:0048666;axonogenesis#GO:0007409;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG184011|UniProtKB=T1FKF2 T1FKF2 20209301 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG172003|UniProtKB=T1F4X6 T1F4X6 20203875 PTHR34639:SF1 PROTEIN FLATTOP PROTEIN FLATTOP cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030 intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG177152|UniProtKB=T1FBA1 T1FBA1 20206100 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG98642|UniProtKB=T1G9P0 T1G9P0 20217786 PTHR48069:SF3 DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 small molecule metabolic process#GO:0044281;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;biosynthetic process#GO:0009058;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;tetrahydrofolate metabolic process#GO:0046653;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;tetrahydrofolate biosynthetic process#GO:0046654 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;reductase#PC00198 Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948 HELRO|EnsemblGenome=HelroG100903|UniProtKB=T1ED19 T1ED19 20194471 PTHR15481:SF0 RIBONUCLEIC ACID BINDING PROTEIN S1 LD23870P-RELATED macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG83919|UniProtKB=T1G5B9 T1G5B9 20216266 PTHR15454:SF75 NISCHARIN RELATED SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161766|UniProtKB=T1ERV8 T1ERV8 20199308 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155903|UniProtKB=T1ELP1 T1ELP1 20197491 PTHR21255:SF4 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 dynein complex#GO:0030286;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG182159|UniProtKB=T1FHU5 T1FHU5 20208394 PTHR11449:SF1 RIBOSOMAL PROTEIN L30 LARGE RIBOSOMAL SUBUNIT PROTEIN EL30 binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG163049|UniProtKB=T1ETL7 T1ETL7 20199917 PTHR15286:SF6 RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN GH01133P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80719|UniProtKB=T1G444 T1G444 20215842 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 response to chemical#GO:0042221;response to stimulus#GO:0050896;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG172593|UniProtKB=T1F5K7 T1F5K7 20204106 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG179143|UniProtKB=T1FE86 T1FE86 20207135 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191159|UniProtKB=T1FSN9 T1FSN9 20211836 PTHR22826:SF106 RHO GUANINE EXCHANGE FACTOR-RELATED TRIO, ISOFORM A guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;neuron projection development#GO:0031175;axon guidance#GO:0007411;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron differentiation#GO:0030182;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008 extrinsic component of membrane#GO:0019898;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG73133|UniProtKB=T1G1A6 T1G1A6 20214854 PTHR18952:SF283 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XB-RELATED metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG77608|UniProtKB=T1G305 T1G305 20215453 PTHR12210:SF202 DULLARD PROTEIN PHOSPHATASE PHOSPHATASE HERZOG hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG122890|UniProtKB=T1EGW3 T1EGW3 20195813 PTHR24072:SF142 RHO FAMILY GTPASE RHOU, ISOFORM B hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;protein binding#GO:0005515;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553 transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;localization#GO:0051179;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG132346|UniProtKB=T1EHY0 T1EHY0 20196180 PTHR10694:SF129 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED protein demethylase activity#GO:0140457;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin organization#GO:0006325;biological regulation#GO:0065007;chromatin remodeling#GO:0006338 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG194391|UniProtKB=T1FW03 T1FW03 20212999 PTHR44281:SF6 SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG centriole replication#GO:0007099;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG180211|UniProtKB=T1FFK7 T1FFK7 20207606 PTHR43968:SF6 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;glutathione transferase activity#GO:0004364;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG170143|UniProtKB=T1F2P8 T1F2P8 20203097 PTHR28663:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 173 CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210 microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoplasmic microtubule#GO:0005881;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512 HELRO|EnsemblGenome=HelroG88144|UniProtKB=T1G6Z1 T1G6Z1 20216838 PTHR10603:SF7 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;positive regulation of nervous system development#GO:0051962;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;animal organ development#GO:0048513;regulation of mRNA metabolic process#GO:1903311;positive regulation of cell differentiation#GO:0045597;regulation of trans-synaptic signaling#GO:0099177;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;regulation of nervous system development#GO:0051960;nucleic acid transport#GO:0050657;anatomical structure development#GO:0048856;localization#GO:0051179;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;positive regulation of translation#GO:0045727;regulation of RNA stability#GO:0043487;RNA localization#GO:0006403;regulation of cellular process#GO:0050794;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;regulation of macromolecule metabolic process#GO:0060255;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;regulation of neuronal synaptic plasticity#GO:0048168;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608;regulation of synaptic plasticity#GO:0048167;regulation of cell differentiation#GO:0045595;transport#GO:0006810;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nitrogen compound transport#GO:0071705;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;macromolecule localization#GO:0033036;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522 membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;neuron projection#GO:0043005;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192412|UniProtKB=T1FTX7 T1FTX7 20212274 PTHR10555:SF170 SORTING NEXIN FI18122P1 anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167 endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;retromer complex#GO:0030904;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175202|UniProtKB=T1F900 T1F900 20205299 PTHR23030:SF42 PCD6 INTERACTING PROTEIN-RELATED SUBFAMILY NOT NAMED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184495|UniProtKB=T1FLB6 T1FLB6 20209615 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG65082|UniProtKB=T1FY32 T1FY32 20213730 PTHR44269:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED IP05441P oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG144008|UniProtKB=T1EJD4 T1EJD4 20196684 PTHR24230:SF166 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62376|UniProtKB=T1FWZ9 T1FWZ9 20213347 PTHR21580:SF57 SHIPPO-1-RELATED OUTER DENSE FIBER OF SPERM TAILS 3-LIKE 2B-RELATED spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;cellular process#GO:0009987;male gamete generation#GO:0048232 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic microtubule#GO:0005881;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 structural protein#PC00211 HELRO|EnsemblGenome=HelroG163656|UniProtKB=T1EUB8 T1EUB8 20200168 PTHR23235:SF204 KRUEPPEL-LIKE TRANSCRIPTION FACTOR ZINC FINGER PROTEIN 235-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG76855|UniProtKB=T1G2Q2 T1G2Q2 20215350 PTHR12705:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 5 ORIGIN RECOGNITION COMPLEX SUBUNIT 5 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690 cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nuclear origin of replication recognition complex#GO:0005664 replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG187311|UniProtKB=T1FP86 T1FP86 20210633 PTHR19960:SF11 TEKTIN LD08455P cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;organelle assembly#GO:0070925;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cell projection organization#GO:0030030;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG66410|UniProtKB=T1FYK8 T1FYK8 20213906 PTHR21530:SF7 PHEROMONE SHUTDOWN PROTEIN TRAB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184905|UniProtKB=T1FM56 T1FM56 20209905 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG80158|UniProtKB=T1G3Y4 T1G3Y4 20215782 PTHR11266:SF128 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MITOCHONDRIAL INNER MEMBRANE PROTEIN MPV17 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG172348|UniProtKB=T1F577 T1F577 20203976 PTHR24056:SF594 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 5 cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cell morphogenesis#GO:0000902;establishment of organelle localization#GO:0051656;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;apoptotic process#GO:0006915;anatomical structure morphogenesis#GO:0009653;cellular localization#GO:0051641;neuron apoptotic process#GO:0051402;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;synaptic vesicle localization#GO:0097479;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;establishment of vesicle localization#GO:0051650;synaptic vesicle transport#GO:0048489;neuron projection development#GO:0031175;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;programmed cell death#GO:0012501;cell death#GO:0008219;anatomical structure development#GO:0048856;localization#GO:0051179;system development#GO:0048731;organelle localization#GO:0051640;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;vesicle localization#GO:0051648;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;neurogenesis#GO:0022008;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502 serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Axon guidance mediated by semaphorins#P00007>Cdk5#P00336;Dopamine receptor mediated signaling pathway#P05912>CDK5#P05951;Nicotine pharmacodynamics pathway#P06587>CDK5#P06597;PDGF signaling pathway#P00047>GSK3#P01153;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902 HELRO|EnsemblGenome=HelroG95979|UniProtKB=T1G995 T1G995 20217642 PTHR11680:SF59 SERINE HYDROXYMETHYLTRANSFERASE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094 tetrahydrofolate metabolic process#GO:0046653;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid biosynthetic process#GO:0170038;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 Serine glycine biosynthesis#P02776>Glycine hydroxymethyltransferase#P03158 HELRO|EnsemblGenome=HelroG179973|UniProtKB=T1FFA6 T1FFA6 20207505 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG125965|UniProtKB=T1EH79 T1EH79 20195929 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;response to stimulus#GO:0050896;protein folding#GO:0006457;protein metabolic process#GO:0019538;protein refolding#GO:0042026;response to stress#GO:0006950;response to heat#GO:0009408;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG165520|UniProtKB=T1EWY7 T1EWY7 20201087 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG172166|UniProtKB=T1F537 T1F537 20203936 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG173224|UniProtKB=T1F6L1 T1F6L1 20204460 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN EXPRESSED PROTEIN methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824 methyltransferase#PC00155;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG80699|UniProtKB=T1G440 T1G440 20215838 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;chloride transport#GO:0006821;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG170281|UniProtKB=T1F2V6 T1F2V6 20203155 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG124458|UniProtKB=T1EH15 T1EH15 20195865 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER FIBROPELLIN-1-LIKE signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG159330|UniProtKB=T1ENW1 T1ENW1 20198261 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG70921|UniProtKB=T1G0E3 T1G0E3 20214541 PTHR15605:SF2 KINESIN-ASSOCIATED PROTEINS KINESIN-ASSOCIATED PROTEIN 3 cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;microtubule-based process#GO:0007017 ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;intracellular organelle#GO:0043229;cilium#GO:0005929 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG193703|UniProtKB=T1FVA1 T1FVA1 20212747 PTHR22948:SF84 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;piRNA processing#GO:0034587;sexual reproduction#GO:0019953;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regionalization#GO:0003002;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;cell maturation#GO:0048469;regulation of gene expression#GO:0010468;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;embryonic pattern specification#GO:0009880;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;embryo development#GO:0009790;oogenesis#GO:0048477;RNA processing#GO:0006396;anterior/posterior pattern specification#GO:0009952;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;anterior/posterior axis specification#GO:0009948;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 intracellular organelle#GO:0043229;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG147323|UniProtKB=T1EJZ3 T1EJZ3 20196893 PTHR11849:SF289 ETS ETS-LIKE PROTEIN POINTED DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG95556|UniProtKB=T1G968 T1G968 20217615 PTHR13148:SF0 PER1-RELATED GPI-SPECIFIC PHOSPHOLIPASE A2-LIKE PGAP3 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 gene expression#GO:0010467;protein maturation#GO:0051604;GPI anchored protein biosynthesis#GO:0180046;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG183195|UniProtKB=T1FJA2 T1FJA2 20208901 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG167274|UniProtKB=T1EZ76 T1EZ76 20201876 PTHR21552:SF2 ADULT RETINA PROTEIN CREB3 REGULATORY FACTOR RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG80632|UniProtKB=T1G431 T1G431 20215829 PTHR43201:SF5 ACYL-COA SYNTHETASE MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG171742|UniProtKB=T1F4L4 T1F4L4 20203763 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG177554|UniProtKB=T1FBV6 T1FBV6 20206305 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189291|UniProtKB=T1FQX4 T1FQX4 20211221 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG70741|UniProtKB=T1G0B5 T1G0B5 20214513 PTHR19411:SF0 PROTEIN BUD31-RELATED PROTEIN BUD31 HOMOLOG mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185872|UniProtKB=T1FND7 T1FND7 20210334 PTHR46260:SF3 RING-TYPE DOMAIN-CONTAINING PROTEIN KELCH REPEAT-CONTAINING PROTEIN DDB_G0274267-RELATED HELRO|EnsemblGenome=HelroG185883|UniProtKB=T1FNE2 T1FNE2 20210339 PTHR10502:SF247 ANNEXIN ANNEXIN B10 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;ion binding#GO:0043167;phospholipid binding#GO:0005543;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG68387|UniProtKB=T1FZD8 T1FZD8 20214186 PTHR21635:SF1 LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG181243|UniProtKB=T1FGS3 T1FGS3 20208022 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80019|UniProtKB=T1G3W6 T1G3W6 20215764 PTHR16074:SF4 BARDET-BIEDL SYNDROME 7 PROTEIN BBSOME COMPLEX MEMBER BBS7 cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;BBSome#GO:0034464;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815 HELRO|EnsemblGenome=HelroG171602|UniProtKB=T1F4G0 T1F4G0 20203709 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113091|UniProtKB=T1EFQ1 T1EFQ1 20195403 PTHR22168:SF3 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG159794|UniProtKB=T1EPE9 T1EPE9 20198449 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG194114|UniProtKB=T1FVP7 T1FVP7 20212893 PTHR21373:SF1 GLUCOSE REPRESSIBLE PROTEIN MAK10 N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG178532|UniProtKB=T1FDB7 T1FDB7 20206816 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG113018|UniProtKB=T1EFP6 T1EFP6 20195398 PTHR11106:SF123 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stress#GO:0006950;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;cellular response to stimulus#GO:0051716;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;purine nucleoside metabolic process#GO:0042278 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG80663|UniProtKB=T1G436 T1G436 20215834 PTHR28580:SF1 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5 DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;gene expression#GO:0010467;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA repair#GO:0006281;metabolic process#GO:0008152 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIIH core complex#GO:0000439;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161330|UniProtKB=T1ERC6 T1ERC6 20199126 PTHR11985:SF15 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG78950|UniProtKB=T1G3H6 T1G3H6 20215624 PTHR23105:SF54 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 RNA binding#GO:0003723;snoRNA binding#GO:0030515;binding#GO:0005488;nucleic acid binding#GO:0003676 snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG174630|UniProtKB=T1F8B5 T1F8B5 20205064 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159354|UniProtKB=T1ENX5 T1ENX5 20198275 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG164242|UniProtKB=T1EV56 T1EV56 20200456 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG151764|UniProtKB=T1EKM0 T1EKM0 20197120 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;dynein complex#GO:0030286;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188123|UniProtKB=T1FPN9 T1FPN9 20210786 PTHR21419:SF30 FAMILY NOT NAMED FAM234A_B BETA-PROPELLER DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192900|UniProtKB=T1FUE4 T1FUE4 20212440 PTHR23322:SF6 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 7 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191565|UniProtKB=T1FT32 T1FT32 20211979 PTHR22969:SF17 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>IKK#P00313 HELRO|EnsemblGenome=HelroG102916|UniProtKB=T1EDD1 T1EDD1 20194583 PTHR15288:SF0 DENN DOMAIN-CONTAINING PROTEIN 2 UDENN DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG169987|UniProtKB=T1F2I0 T1F2I0 20203030 PTHR21049:SF0 RIBOPHORIN I DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG184843|UniProtKB=T1FM27 T1FM27 20209876 PTHR10869:SF216 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROCOLLAGEN-PROLINE 4-DIOXYGENASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;oxidoreductase complex#GO:1990204;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165806|UniProtKB=T1EXB0 T1EXB0 20201210 PTHR13140:SF729 MYOSIN UNCONVENTIONAL MYOSIN-IE microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cytoskeleton organization#GO:0007010;transport#GO:0006810;actin filament-based process#GO:0030029;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;microvillus#GO:0005902;actin-based cell projection#GO:0098858;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG88037|UniProtKB=T1G6X7 T1G6X7 20216824 PTHR23167:SF46 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175357|UniProtKB=T1F968 T1F968 20205367 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65752|UniProtKB=T1FYC3 T1FYC3 20213821 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER LD05335P monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 cellular process#GO:0009987;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transition metal ion transport#GO:0000041;transport#GO:0006810;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG86199|UniProtKB=T1G683 T1G683 20216580 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG62108|UniProtKB=T1FWV9 T1FWV9 20213307 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161512|UniProtKB=T1ERK6 T1ERK6 20199206 PTHR23325:SF1 SERUM RESPONSE FACTOR-BINDING SERUM RESPONSE FACTOR-BINDING PROTEIN 1 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 ribonucleoprotein complex#GO:1990904;90S preribosome#GO:0030686;preribosome#GO:0030684;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG73772|UniProtKB=T1G1I2 T1G1I2 20214930 PTHR23086:SF101 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 59B, ISOFORM J-RELATED lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transferase#PC00220;kinase#PC00137 HELRO|EnsemblGenome=HelroG95975|UniProtKB=T1G994 T1G994 20217641 PTHR13038:SF10 APG9 AUTOPHAGY 9 AUTOPHAGY-RELATED PROTEIN 9 intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;reticulophagy#GO:0061709;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;localization#GO:0051179;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;cellular component organization#GO:0016043 vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;autophagosome#GO:0005776 HELRO|EnsemblGenome=HelroG172460|UniProtKB=T1F5C8 T1F5C8 20204027 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179229|UniProtKB=T1FEE1 T1FEE1 20207190 PTHR13667:SF5 HOMOLOC-13 WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG HELRO|EnsemblGenome=HelroG174686|UniProtKB=T1F8D4 T1F8D4 20205083 PTHR16515:SF21 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG193530|UniProtKB=T1FV33 T1FV33 20212679 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG165659|UniProtKB=T1EX51 T1EX51 20201151 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG79073|UniProtKB=T1G3K0 T1G3K0 20215648 PTHR12442:SF5 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 3 protein binding#GO:0005515;binding#GO:0005488 protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;inner dynein arm assembly#GO:0036159;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cell motility#GO:0048870;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cilium assembly#GO:0060271 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;inner dynein arm#GO:0036156 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG72781|UniProtKB=T1G155 T1G155 20214803 PTHR24012:SF885 RNA BINDING PROTEIN PROTEIN SEX-LETHAL RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG170690|UniProtKB=T1F3B5 T1F3B5 20203314 PTHR21190:SF1 GH10077P GH10077P HELRO|EnsemblGenome=HelroG128998|UniProtKB=T1EHR3 T1EHR3 20196113 PTHR45628:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1 channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transmembrane import into cytosol#GO:0097553;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816 cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241 5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096 HELRO|EnsemblGenome=HelroG106517|UniProtKB=T1EE31 T1EE31 20194833 PTHR17972:SF0 NUCLEOLAR RNA-ASSOCIATED PROTEIN NUCLEOLAR PROTEIN 6 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;90S preribosome#GO:0030686;small-subunit processome#GO:0032040;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG136083|UniProtKB=T1EIB8 T1EIB8 20196318 PTHR48025:SF30 OS02G0815200 PROTEIN RIBONUCLEOPROTEIN, PTB BINDING 1 HELRO|EnsemblGenome=HelroG189201|UniProtKB=T1FQS2 T1FQS2 20211169 PTHR10082:SF60 INTEGRIN BETA SUBUNIT INTEGRIN BETA-PS protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell migration#GO:0016477;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;cell adhesion mediated by integrin#GO:0033627;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to stimulus#GO:0050896;signaling#GO:0023052;integrin-mediated signaling pathway#GO:0007229;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160 signaling receptor complex#GO:0043235;anchoring junction#GO:0070161;cell junction#GO:0030054;integrin complex#GO:0008305;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;membrane protein complex#GO:0098796;membrane#GO:0016020;focal adhesion#GO:0005925;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HELRO|EnsemblGenome=HelroG72310|UniProtKB=T1G0Y1 T1G0Y1 20214729 PTHR28554:SF1 39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML45 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG75748|UniProtKB=T1G296 T1G296 20215194 PTHR12875:SF3 GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG184206|UniProtKB=T1FKR6 T1FKR6 20209415 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG153317|UniProtKB=T1EL35 T1EL35 20197285 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99199|UniProtKB=T1G9R4 T1G9R4 20217810 PTHR48030:SF7 SPLICING FACTOR 3B SUBUNIT 4 SPLICING FACTOR 3B SUBUNIT 4 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG164701|UniProtKB=T1EVR0 T1EVR0 20200660 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG172119|UniProtKB=T1F518 T1F518 20203917 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED PROTEIN NSUN7 HELRO|EnsemblGenome=HelroG155739|UniProtKB=T1ELL7 T1ELL7 20197467 PTHR45857:SF4 FORMIN-LIKE PROTEIN MULTIPLE WING HAIRS, ISOFORM C HELRO|EnsemblGenome=HelroG162688|UniProtKB=T1ET05 T1ET05 20199705 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183105|UniProtKB=T1FJ56 T1FJ56 20208855 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166516|UniProtKB=T1EY72 T1EY72 20201522 PTHR10927:SF1 RIBOSOME MATURATION PROTEIN SBDS RIBOSOME MATURATION PROTEIN SBDS RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG102544|UniProtKB=T1EDA3 T1EDA3 20194555 PTHR19134:SF542 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 cell communication#GO:0007154;synaptic membrane adhesion#GO:0099560;synapse organization#GO:0050808;cell adhesion#GO:0007155;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194870|UniProtKB=T1FWI2 T1FWI2 20213177 PTHR12826:SF13 RIBONUCLEASE Y RNA-BINDING PROTEIN PNO1 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG167111|UniProtKB=T1EZ11 T1EZ11 20201811 PTHR46787:SF1 SYNDROMES PUTATIVE CHAPERONIN-RELATED MOLECULAR CHAPERONE MKKS cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium organization#GO:0044782;chaperone-mediated protein complex assembly#GO:0051131;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005;nucleus#GO:0005634;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;intracellular organelle#GO:0043229;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG178468|UniProtKB=T1FD76 T1FD76 20206775 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG171517|UniProtKB=T1F4D2 T1F4D2 20203681 PTHR18849:SF8 LEUCINE RICH REPEAT PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61 HELRO|EnsemblGenome=HelroG189219|UniProtKB=T1FQT3 T1FQT3 20211180 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG178276|UniProtKB=T1FD09 T1FD09 20206708 PTHR24347:SF427 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK3 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG166091|UniProtKB=T1EXR0 T1EXR0 20201360 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG93617|UniProtKB=T1G8X0 T1G8X0 20217517 PTHR10288:SF356 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG186124|UniProtKB=T1FNP5 T1FNP5 20210442 PTHR23063:SF2 PHOSPHOLIPID ACYLTRANSFERASE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG77706|UniProtKB=T1G327 T1G327 20215475 PTHR10064:SF0 60S RIBOSOMAL PROTEIN L22 LARGE RIBOSOMAL SUBUNIT PROTEIN EL22 binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG66265|UniProtKB=T1FYI8 T1FYI8 20213886 PTHR11537:SF259 VOLTAGE-GATED POTASSIUM CHANNEL KCNQ POTASSIUM CHANNEL, ISOFORM F transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG92517|UniProtKB=T1G8I0 T1G8I0 20217377 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG88632|UniProtKB=T1G746 T1G746 20216893 PTHR43798:SF37 MONOACYLGLYCEROL LIPASE LIPID DROPLET HYDROLASE 1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788 neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;glycerolipid catabolic process#GO:0046503;neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG64096|UniProtKB=T1FXP1 T1FXP1 20213589 PTHR45725:SF22 FORMIN HOMOLOGY 2 FAMILY MEMBER DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG72730|UniProtKB=T1G145 T1G145 20214793 PTHR19134:SF559 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190174|UniProtKB=T1FRR5 T1FRR5 20211512 PTHR45902:SF4 LATROPHILIN RECEPTOR-LIKE PROTEIN A G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188772|UniProtKB=T1FQC3 T1FQC3 20211020 PTHR10333:SF114 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 3 histone reader activity#GO:0140566;histone H3 reader activity#GO:0140006;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;chromatin-protein adaptor activity#GO:0140463 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325 membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG179880|UniProtKB=T1FF81 T1FF81 20207480 PTHR37153:SF1 CHROMOSOME 19 C19ORF81 HOMOLOG SIMLAR TO HUMAN CHROMOSOME 19 OPEN READING FRAME 81 HELRO|EnsemblGenome=HelroG109220|UniProtKB=T1EER5 T1EER5 20195067 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70969|UniProtKB=T1G0F1 T1G0F1 20214549 PTHR24092:SF190 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;intramembrane lipid carrier activity#GO:0140303 cellular component organization#GO:0016043;Golgi organization#GO:0007030;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;lipid transport#GO:0006869;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG67787|UniProtKB=T1FZ53 T1FZ53 20214101 PTHR13342:SF2 RAGULATOR COMPLEX PROTEIN LAMTOR5 RAGULATOR COMPLEX PROTEIN LAMTOR5 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of TORC1 signaling#GO:1904263;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;response to acid chemical#GO:0001101;regulation of TORC1 signaling#GO:1903432;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;cellular response to amino acid stimulus#GO:0071230;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323 HELRO|EnsemblGenome=HelroG161572|UniProtKB=T1ERM7 T1ERM7 20199227 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG108114|UniProtKB=T1EEF6 T1EEF6 20194958 PTHR11097:SF8 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP42 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA catabolic process#GO:0006401 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG92073|UniProtKB=T1G8B9 T1G8B9 20217316 PTHR12245:SF11 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN PROTEIN GUSTAVUS enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG166083|UniProtKB=T1EXQ4 T1EXQ4 20201354 PTHR31383:SF2 OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1 OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1 HELRO|EnsemblGenome=HelroG77464|UniProtKB=T1G2Y2 T1G2Y2 20215430 PTHR10983:SF73 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG166746|UniProtKB=T1EYG7 T1EYG7 20201617 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186141|UniProtKB=T1FNQ2 T1FNQ2 20210449 PTHR13130:SF4 34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG179131|UniProtKB=T1FE78 T1FE78 20207127 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194498|UniProtKB=T1FW45 T1FW45 20213041 PTHR24184:SF28 SI:CH211-189E2.2 ANKYRIN REPEAT AND SOCS BOX CONTAINING 3 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG172659|UniProtKB=T1F5R0 T1F5R0 20204159 PTHR24416:SF631 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE STYK1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG135734|UniProtKB=T1EIA2 T1EIA2 20196302 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG93768|UniProtKB=T1G8X7 T1G8X7 20217524 PTHR12691:SF10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG78563|UniProtKB=T1G3D0 T1G3D0 20215578 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;tetrapyrrole binding#GO:0046906;binding#GO:0005488;steroid hydroxylase activity#GO:0008395 metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629;response to chemical#GO:0042221;response to stimulus#GO:0050896;steroid metabolic process#GO:0008202;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG176735|UniProtKB=T1FAU8 T1FAU8 20205947 PTHR13512:SF2 MEDIATOR COMPLEX SUBUNIT 28 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161908|UniProtKB=T1ES12 T1ES12 20199362 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG113778|UniProtKB=T1EFW3 T1EFW3 20195465 PTHR10997:SF18 IMPORTIN-7, 8, 11 D-IMPORTIN 7_RANBP7 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG169884|UniProtKB=T1F2E5 T1F2E5 20202995 PTHR19317:SF0 PRENYLATED RAB ACCEPTOR 1-RELATED PRENYLATED RAB ACCEPTOR PROTEIN 1 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG160492|UniProtKB=T1EQB2 T1EQB2 20198762 PTHR46786:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 3 ZINC FINGER MATRIN-TYPE PROTEIN 3 RNA metabolism protein#PC00031;RNA processing factor#PC00147 p53 pathway#P00059>PAG608#G04690 HELRO|EnsemblGenome=HelroG160229|UniProtKB=T1EQ01 T1EQ01 20198651 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90841|UniProtKB=T1G7W8 T1G7W8 20217165 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;anterior/posterior pattern specification#GO:0009952;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regionalization#GO:0003002;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG173902|UniProtKB=T1F7C4 T1F7C4 20204723 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193399|UniProtKB=T1FUY4 T1FUY4 20212630 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER KARMOISIN, ISOFORM B monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG94763|UniProtKB=T1G929 T1G929 20217576 PTHR18929:SF210 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A4 protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096 macromolecule biosynthetic process#GO:0009059;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG111140|UniProtKB=T1EF87 T1EF87 20195239 PTHR23429:SF7 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;glucose-6-phosphate dehydrogenase activity#GO:0004345 pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;pentose-phosphate shunt, oxidative branch#GO:0009051;generation of precursor metabolites and energy#GO:0006091;glucose metabolic process#GO:0006006;nucleobase-containing small molecule metabolic process#GO:0055086;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG194517|UniProtKB=T1FW54 T1FW54 20213050 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG193233|UniProtKB=T1FUR9 T1FUR9 20212565 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG157169|UniProtKB=T1EM75 T1EM75 20197675 PTHR11528:SF144 HEAT SHOCK PROTEIN 90 FAMILY MEMBER ENDOPLASMIN binding#GO:0005488;ATP binding#GO:0005524;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;ATP-dependent activity#GO:0140657;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 protein folding#GO:0006457;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;biosynthetic process#GO:0009058;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 Hsp90 family chaperone#PC00028;chaperone#PC00072 HELRO|EnsemblGenome=HelroG81350|UniProtKB=T1G4D5 T1G4D5 20215933 PTHR23506:SF45 GH10249P GH10249P monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;solute:sodium symporter activity#GO:0015370;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108 synaptic vesicle cycle#GO:0099504;transport#GO:0006810;localization#GO:0051179;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;cellular localization#GO:0051641;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836 organelle membrane#GO:0031090;axon terminus#GO:0043679;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;axon#GO:0030424;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;terminal bouton#GO:0043195;distal axon#GO:0150034;neuron projection terminus#GO:0044306;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular vesicle#GO:0097708;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 secondary carrier transporter#PC00258;transporter#PC00227 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424 HELRO|EnsemblGenome=HelroG109323|UniProtKB=T1EES4 T1EES4 20195076 PTHR24031:SF292 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX54 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG172725|UniProtKB=T1F5V0 T1F5V0 20204199 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76849|UniProtKB=T1G2Q1 T1G2Q1 20215349 PTHR11827:SF6 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 8 symporter activity#GO:0015293;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG187611|UniProtKB=T1FPB0 T1FPB0 20210657 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;synaptic signaling#GO:0099536 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG110881|UniProtKB=T1EF61 T1EF61 20195213 PTHR23069:SF0 AAA DOMAIN-CONTAINING TAT-BINDING HOMOLOG 7 ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;histone binding#GO:0042393;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682 positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;transcription initiation-coupled chromatin remodeling#GO:0045815;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;chromatin remodeling#GO:0006338;DNA-templated transcription initiation#GO:0006352;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nucleosome organization#GO:0034728;regulation of biosynthetic process#GO:0009889;transcription by RNA polymerase II#GO:0006366;RNA biosynthetic process#GO:0032774;protein-containing complex disassembly#GO:0032984;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of biosynthetic process#GO:0009891 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG89924|UniProtKB=T1G7J1 T1G7J1 20217038 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG186189|UniProtKB=T1FNS5 T1FNS5 20210472 PTHR23291:SF112 BAX INHIBITOR-RELATED GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 calcium ion transmembrane transport#GO:0070588;cellular component organization#GO:0016043;metal ion transport#GO:0030001;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;organelle organization#GO:0006996;mitochondrial calcium ion transmembrane transport#GO:0006851;mitochondrial membrane organization#GO:0007006;release of sequestered calcium ion into cytosol#GO:0051209;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG169273|UniProtKB=T1F1P4 T1F1P4 20202744 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG189905|UniProtKB=T1FRG9 T1FRG9 20211416 PTHR31395:SF29 SHISA S-LAYER HOMOLOGY DOMAIN-RELATED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189071|UniProtKB=T1FQM1 T1FQM1 20211118 PTHR21567:SF89 CLASP CLIP-ASSOCIATING PROTEIN protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;organelle localization#GO:0051640;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;spindle organization#GO:0007051;establishment of localization#GO:0051234;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;mitotic sister chromatid segregation#GO:0000070;establishment of spindle localization#GO:0051293;mitotic spindle assembly#GO:0090307;spindle localization#GO:0051653;cellular localization#GO:0051641;nuclear division#GO:0000280;mitotic spindle organization#GO:0007052;establishment of organelle localization#GO:0051656;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;establishment of mitotic spindle localization#GO:0040001;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule organizing center#GO:0005815;spindle#GO:0005819;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;mitotic spindle#GO:0072686;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;kinetochore#GO:0000776;basal part of cell#GO:0045178;chromosome#GO:0005694;cytoplasmic microtubule#GO:0005881;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;microtubule#GO:0005874;spindle microtubule#GO:0005876;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG111847|UniProtKB=T1EFF0 T1EFF0 20195302 PTHR10454:SF232 CASPASE CASPASE-8 cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 positive regulation of apoptotic process#GO:0043065;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;programmed cell death#GO:0012501;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;cellular process#GO:0009987;apoptotic process#GO:0006915;cell death#GO:0008219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG114533|UniProtKB=T1EG26 T1EG26 20195528 PTHR18806:SF4 RBM25 PROTEIN RNA-BINDING PROTEIN 25 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484 HELRO|EnsemblGenome=HelroG161090|UniProtKB=T1ER34 T1ER34 20199034 PTHR46145:SF4 HEPARANASE HEPARANASE glycosidase#PC00110 HELRO|EnsemblGenome=HelroG119855|UniProtKB=T1EGN8 T1EGN8 20195738 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;metal ion transport#GO:0030001;action potential#GO:0001508;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG111197|UniProtKB=T1EF95 T1EF95 20195247 PTHR44156:SF5 SUPERNUMERARY LIMBS, ISOFORM B-RELATED WD REPEAT-CONTAINING PROTEIN 55 HELRO|EnsemblGenome=HelroG191907|UniProtKB=T1FTE6 T1FTE6 20212093 PTHR23063:SF63 PHOSPHOLIPID ACYLTRANSFERASE LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193671|UniProtKB=T1FV89 T1FV89 20212735 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG185476|UniProtKB=T1FMV3 T1FMV3 20210152 PTHR42738:SF7 HYDROXYMETHYLGLUTARYL-COA LYASE HYDROXYMETHYLGLUTARYL-COA LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;lipid biosynthetic process#GO:0008610;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 lyase#PC00144 HELRO|EnsemblGenome=HelroG164299|UniProtKB=T1EV85 T1EV85 20200485 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 HELRO|EnsemblGenome=HelroG163112|UniProtKB=T1ETN8 T1ETN8 20199938 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG193494|UniProtKB=T1FV19 T1FV19 20212665 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG161662|UniProtKB=T1ERR5 T1ERR5 20199265 PTHR16231:SF2 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 7 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cell communication#GO:0007154;tumor necrosis factor-mediated signaling pathway#GO:0033209;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;response to tumor necrosis factor#GO:0034612;signal transduction#GO:0007165;cellular process#GO:0009987 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG75751|UniProtKB=T1G297 T1G297 20215195 PTHR24270:SF8 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED VITELLOGENIN RECEPTOR YL membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG112284|UniProtKB=T1EFI3 T1EFI3 20195335 PTHR24345:SF99 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;spindle pole#GO:0000922;kinetochore#GO:0000776;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG166500|UniProtKB=T1EY65 T1EY65 20201515 PTHR12774:SF2 PEROXISOMAL BIOGENESIS FACTOR 19 PEROXISOMAL BIOGENESIS FACTOR 19 signal sequence receptor activity#GO:0005048 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;peroxisomal transport#GO:0043574;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;peroxisome organization#GO:0007031;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG100002|UniProtKB=T1ECX9 T1ECX9 20194431 PTHR11006:SF4 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 7 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;histone modifying activity#GO:0140993;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165422|UniProtKB=T1EWR6 T1EWR6 20201016 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97472|UniProtKB=T1G9G8 T1G9G8 20217715 PTHR12431:SF14 SORTING NEXIN 17 AND 27 LD15323P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456;transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;metabolic process#GO:0008152;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;macromolecule metabolic process#GO:0043170 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165410|UniProtKB=T1EWQ8 T1EWQ8 20201008 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112561|UniProtKB=T1EFK7 T1EFK7 20195359 PTHR22883:SF405 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612 Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172392|UniProtKB=T1F590 T1F590 20203989 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG109066|UniProtKB=T1EEQ2 T1EEQ2 20195054 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG185366|UniProtKB=T1FMQ5 T1FMQ5 20210104 PTHR45684:SF2 RE74312P SMALL MONOMERIC GTPASE hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;COPII-coated vesicle budding#GO:0090114;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;membrane organization#GO:0061024;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810 organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;transport vesicle#GO:0030133;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;vesicle coat#GO:0030120;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971 HELRO|EnsemblGenome=HelroG184133|UniProtKB=T1FKN0 T1FKN0 20209379 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174588|UniProtKB=T1F8A1 T1F8A1 20205050 PTHR12320:SF78 PROTEIN PHOSPHATASE 2C SUBFAMILY NOT NAMED hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG189420|UniProtKB=T1FR17 T1FR17 20211264 PTHR45976:SF1 ARMADILLO SEGMENT POLARITY PROTEIN ARMADILLO SEGMENT POLARITY PROTEIN transcription coactivator activity#GO:0003713;protein phosphatase binding#GO:0019903;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712;cell adhesion molecule binding#GO:0050839;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;phosphatase binding#GO:0019902;binding#GO:0005488;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;Wnt signaling pathway#GO:0016055;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cell adhesion#GO:0007155;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 adherens junction#GO:0005912;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796 p53 pathway feedback loops 2#P04398>beta-catenin#P04670;Cadherin signaling pathway#P00012>betacatenin#P00463;Wnt signaling pathway#P00057>Beta-Catenin#P01432;Angiogenesis#P00005>beta catenin#P00187;Alzheimer disease-presenilin pathway#P00004>beta-catenin#P00156 HELRO|EnsemblGenome=HelroG90391|UniProtKB=T1G7Q5 T1G7Q5 20217102 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182056|UniProtKB=T1FHN9 T1FHN9 20208338 PTHR19282:SF516 TETRASPANIN LEUKOCYTE ANTIGEN CD37 ISOFORM X1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG114074|UniProtKB=T1EFY8 T1EFY8 20195490 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG174628|UniProtKB=T1F8B3 T1F8B3 20205062 PTHR44027:SF8 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;cell projection#GO:0042995;neuron projection terminus#GO:0044306;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynapse#GO:0098793;neuron projection#GO:0043005;axon terminus#GO:0043679;cell junction#GO:0030054;axon#GO:0030424 chaperone#PC00072 HELRO|EnsemblGenome=HelroG157830|UniProtKB=T1EMG5 T1EMG5 20197765 PTHR13007:SF19 PRE-MRNA SPLICING FACTOR-RELATED PRE-MRNA-SPLICING FACTOR 18 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;nuclear protein-containing complex#GO:0140513;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG72364|UniProtKB=T1G0Y9 T1G0Y9 20214737 PTHR12062:SF9 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794 transferase#PC00220 HELRO|EnsemblGenome=HelroG161685|UniProtKB=T1ERS5 T1ERS5 20199275 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG161400|UniProtKB=T1ERF9 T1ERF9 20199159 PTHR21389:SF0 P53 INDUCED PROTEIN ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG catabolic process#GO:0009056;macroautophagy#GO:0016236;process utilizing autophagic mechanism#GO:0061919;metabolic process#GO:0008152;autophagy#GO:0006914;cellular process#GO:0009987 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG181161|UniProtKB=T1FGP2 T1FGP2 20207991 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG187336|UniProtKB=T1FP89 T1FP89 20210636 PTHR23305:SF11 OBG GTPASE FAMILY OBG-LIKE ATPASE 1 hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein#PC00020 HELRO|EnsemblGenome=HelroG122743|UniProtKB=T1EGV5 T1EGV5 20195805 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG113964|UniProtKB=T1EFX7 T1EFX7 20195479 PTHR23127:SF0 CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1 isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA modification#GO:0016556;snRNA processing#GO:0016180;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085 organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 centromere DNA-binding protein#PC00071;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG72659|UniProtKB=T1G134 T1G134 20214782 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A8-LIKE oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159077|UniProtKB=T1ENK2 T1ENK2 20198152 PTHR23236:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H RNA-BINDING PROTEIN 34 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG157766|UniProtKB=T1EMF5 T1EMF5 20197755 PTHR12001:SF44 GERANYLGERANYL PYROPHOSPHATE SYNTHASE GERANYLGERANYL PYROPHOSPHATE SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;metabolic process#GO:0008152;isoprenoid metabolic process#GO:0006720;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Dimethylallyl trans-transferase#P00490 HELRO|EnsemblGenome=HelroG68497|UniProtKB=T1FZF8 T1FZF8 20214206 PTHR22808:SF1 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING TRNA (CYTOSINE(34)-C(5))-METHYLTRANSFERASE catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;mitochondrial ribosome assembly#GO:0061668;rRNA metabolic process#GO:0016072;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribosomal large subunit assembly#GO:0000027;macromolecule biosynthetic process#GO:0009059;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;organelle assembly#GO:0070925;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial large ribosomal subunit assembly#GO:1902775;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;tRNA processing#GO:0008033;protein-containing complex organization#GO:0043933;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;tRNA methylation#GO:0030488;methylation#GO:0032259;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;tRNA modification#GO:0006400;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;tRNA wobble base modification#GO:0002097;protein-containing complex assembly#GO:0065003 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG179198|UniProtKB=T1FEC5 T1FEC5 20207174 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;transcription coregulator activity#GO:0003712;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG163701|UniProtKB=T1EUD3 T1EUD3 20200183 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161373|UniProtKB=T1ERE8 T1ERE8 20199148 PTHR24230:SF158 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG162160|UniProtKB=T1ESA6 T1ESA6 20199456 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183456|UniProtKB=T1FJP5 T1FJP5 20209044 PTHR13633:SF3 MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG109431|UniProtKB=T1EET8 T1EET8 20195090 PTHR46379:SF1 ZINC FINGER MYND DOMAIN-CONTAINING ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11 chromatin-protein adaptor activity#GO:0140463;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;chromatin remodeling#GO:0006338;RNA biosynthetic process#GO:0032774;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription elongation#GO:0006354;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG174892|UniProtKB=T1F8L0 T1F8L0 20205159 PTHR45834:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG177816|UniProtKB=T1FCB4 T1FCB4 20206463 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG175775|UniProtKB=T1F9N0 T1F9N0 20205529 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180212|UniProtKB=T1FFK8 T1FFK8 20207607 PTHR43968:SF6 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;glutathione transferase activity#GO:0004364 sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189224|UniProtKB=T1FQT7 T1FQT7 20211184 PTHR22901:SF0 SIALATE O-ACETYLESTERASE SIALATE O-ACETYLESTERASE hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975 esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG157479|UniProtKB=T1EMB9 T1EMB9 20197719 PTHR47958:SF216 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 reproductive process#GO:0022414;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;nucleus#GO:0005634;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG171464|UniProtKB=T1F4B4 T1F4B4 20203663 PTHR46469:SF1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 General transcription by RNA polymerase I#P00022>TAF-IB#P00650;General transcription by RNA polymerase I#P00022>TAF-IA#P00651;General transcription by RNA polymerase I#P00022>TAF-IC#P00649;General transcription regulation#P00023>TBP-associated factors#P00658;General transcription by RNA polymerase I#P00022>SL1 complex#P00653;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG145478|UniProtKB=T1EJK4 T1EJK4 20196754 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71468|UniProtKB=T1G0M0 T1G0M0 20214618 PTHR22957:SF502 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG161346|UniProtKB=T1ERD2 T1ERD2 20199132 PTHR11276:SF28 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA POLYMERASE LAMBDA DNA-directed DNA polymerase activity#GO:0003887;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;double-strand break repair#GO:0006302 DNA metabolism protein#PC00009;DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG166266|UniProtKB=T1EXY6 T1EXY6 20201436 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185234|UniProtKB=T1FMJ5 T1FMJ5 20210044 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN metallopeptidase activity#GO:0008237;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG177414|UniProtKB=T1FBN2 T1FBN2 20206231 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160256|UniProtKB=T1EQ11 T1EQ11 20198661 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG176339|UniProtKB=T1FAE6 T1FAE6 20205795 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;vesicle#GO:0031982;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG64985|UniProtKB=T1FY22 T1FY22 20213720 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT signaling#GO:0023052;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of translational initiation#GO:0006446;cellular response to stress#GO:0033554;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG113693|UniProtKB=T1EFV1 T1EFV1 20195453 PTHR24208:SF166 LIM/HOMEOBOX PROTEIN LHX LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG156957|UniProtKB=T1EM41 T1EM41 20197641 PTHR22168:SF8 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG73033|UniProtKB=T1G190 T1G190 20214838 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HELRO|EnsemblGenome=HelroG141265|UniProtKB=T1EJ32 T1EJ32 20196582 PTHR10778:SF13 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1 purine nucleotide transmembrane transporter activity#GO:0015216;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG177698|UniProtKB=T1FC35 T1FC35 20206384 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of DNA metabolic process#GO:0051052;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;nucleotide metabolic process#GO:0009117;regulation of cellular response to stress#GO:0080135;ribonucleotide metabolic process#GO:0009259;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleotide-sugar metabolic process#GO:0009225;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG77609|UniProtKB=T1G306 T1G306 20215454 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG180238|UniProtKB=T1FFL9 T1FFL9 20207618 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG109453|UniProtKB=T1EET9 T1EET9 20195091 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG190099|UniProtKB=T1FRP3 T1FRP3 20211490 PTHR14429:SF22 FIBROSIN FAMILY MEMBER AUTISM SUSCEPTIBILITY GENE 2 PROTEIN HOMOLOG ISOFORM X1 HELRO|EnsemblGenome=HelroG75249|UniProtKB=T1G230 T1G230 20215128 PTHR45668:SF3 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG191074|UniProtKB=T1FSK3 T1FSK3 20211800 PTHR12133:SF2 TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098 RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG136099|UniProtKB=T1EIB9 T1EIB9 20196319 PTHR11636:SF76 POU DOMAIN PROTEIN NUBBIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG188048|UniProtKB=T1FPK8 T1FPK8 20210755 PTHR11616:SF340 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;glycine transmembrane transporter activity#GO:0015187;amino acid transmembrane transporter activity#GO:0015171;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;carboxylic acid transmembrane transporter activity#GO:0046943 establishment of localization#GO:0051234;import into cell#GO:0098657;amino acid transport#GO:0006865;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;glycine transport#GO:0015816;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG185380|UniProtKB=T1FMQ8 T1FMQ8 20210107 PTHR13373:SF21 FROUNT PROTEIN-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP85 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 protein transport#GO:0015031;protein import into nucleus#GO:0006606;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;gene expression#GO:0010467;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nucleus#GO:0005634;nuclear pore outer ring#GO:0031080;organelle envelope#GO:0031967 structural protein#PC00211 HELRO|EnsemblGenome=HelroG65856|UniProtKB=T1FYD8 T1FYD8 20213836 PTHR11545:SF45 RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of translation#GO:0017148;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG166915|UniProtKB=T1EYQ9 T1EYQ9 20201709 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 TITIN-LIKE HELRO|EnsemblGenome=HelroG189070|UniProtKB=T1FQM0 T1FQM0 20211117 PTHR22760:SF4 GLYCOSYLTRANSFERASE GPI ALPHA-1,2-MANNOSYLTRANSFERASE 3 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG169350|UniProtKB=T1F1T6 T1F1T6 20202786 PTHR45715:SF6 ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED V-TYPE PROTON ATPASE SUBUNIT E monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;proton-transporting two-sector ATPase complex#GO:0016469;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;ATPase complex#GO:1904949;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495 HELRO|EnsemblGenome=HelroG109966|UniProtKB=T1EEX8 T1EEX8 20195130 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG182318|UniProtKB=T1FI21 T1FI21 20208470 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG185431|UniProtKB=T1FMT4 T1FMT4 20210133 PTHR24347:SF454 SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLASE KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;energy reserve metabolic process#GO:0006112;polysaccharide metabolic process#GO:0005976;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;carbohydrate metabolic process#GO:0005975;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG77520|UniProtKB=T1G2Z2 T1G2Z2 20215440 PTHR21213:SF0 GEO09665P1-RELATED ZINC FINGER PROTEIN 706 HELRO|EnsemblGenome=HelroG90264|UniProtKB=T1G7N6 T1G7N6 20217083 PTHR43150:SF11 HYPERKINETIC, ISOFORM M HYPERKINETIC, ISOFORM M protein binding#GO:0005515;channel regulator activity#GO:0016247;binding#GO:0005488;transporter regulator activity#GO:0141108;transmembrane transporter binding#GO:0044325;potassium channel regulator activity#GO:0015459;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106 regulation of biological process#GO:0050789;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049 membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 HELRO|EnsemblGenome=HelroG184362|UniProtKB=T1FL19 T1FL19 20209518 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77652|UniProtKB=T1G316 T1G316 20215464 PTHR12728:SF0 BRIX DOMAIN CONTAINING PROTEIN RIBOSOME PRODUCTION FACTOR 2 HOMOLOG binding#GO:0005488;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG112481|UniProtKB=T1EFK3 T1EFK3 20195355 PTHR11254:SF395 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SMURF1 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;negative regulation of BMP signaling pathway#GO:0030514;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;primary metabolic process#GO:0044238;negative regulation of cell communication#GO:0010648;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Activin beta signaling pathway#P06210>LACK#P06230;DPP signaling pathway#P06213>LACK#P06278;GBB signaling pathway#P06214>LACK#P06303;MYO signaling pathway#P06215>LACK#P06309;TGF-beta signaling pathway#P00052>Smurfs#P01279;ALP23B signaling pathway#P06209>LACK#P06219;SCW signaling pathway#P06216>LACK#P06321;BMP/activin signaling pathway-drosophila#P06211>Smurf#P06243;DPP-SCW signaling pathway#P06212>LACK#P06269 HELRO|EnsemblGenome=HelroG157320|UniProtKB=T1EM97 T1EM97 20197697 PTHR43977:SF1 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 HELRO|EnsemblGenome=HelroG191598|UniProtKB=T1FT42 T1FT42 20211989 PTHR11037:SF21 TRANSCRIPTION FACTOR CP2 GEMINI, ISOFORM C transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG85297|UniProtKB=T1G5V1 T1G5V1 20216448 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG79474|UniProtKB=T1G3P2 T1G3P2 20215690 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG184240|UniProtKB=T1FKU1 T1FKU1 20209440 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189570|UniProtKB=T1FR59 T1FR59 20211306 PTHR12948:SF3 NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN NEDD8 ULTIMATE BUSTER 1 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of catabolic process#GO:0009894;regulation of protein catabolic process#GO:0042176 HELRO|EnsemblGenome=HelroG108787|UniProtKB=T1EEM4 T1EEM4 20195026 PTHR11662:SF461 SOLUTE CARRIER FAMILY 17 MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG184051|UniProtKB=T1FKH6 T1FKH6 20209325 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178666|UniProtKB=T1FDJ1 T1FDJ1 20206890 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mRNA splicing#P00058>U5#P01474 HELRO|EnsemblGenome=HelroG194538|UniProtKB=T1FW62 T1FW62 20213058 PTHR11134:SF4 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-4 COMPLEX SUBUNIT BETA-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;AP-type membrane coat adaptor complex#GO:0030119;Golgi apparatus#GO:0005794;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158443|UniProtKB=T1EMS7 T1EMS7 20197877 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108864|UniProtKB=T1EEN2 T1EEN2 20195034 PTHR24058:SF12 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transcription coregulator activity#GO:0003712;transferase activity#GO:0016740;catalytic activity#GO:0003824;transcription coactivator activity#GO:0003713;catalytic activity, acting on a protein#GO:0140096;transcription regulator activity#GO:0140110;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77102|UniProtKB=T1G2T2 T1G2T2 20215380 PTHR12296:SF30 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN CRAG molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG163238|UniProtKB=T1ETT7 T1ETT7 20199987 PTHR28653:SF1 FAMILY NOT NAMED ATPASE SWSAP1 HELRO|EnsemblGenome=HelroG184962|UniProtKB=T1FM75 T1FM75 20209924 PTHR11073:SF1 CALRETICULIN AND CALNEXIN CALNEXIN 14D-RELATED calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;biosynthetic process#GO:0009058;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;protein folding#GO:0006457;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 chaperone#PC00072 HELRO|EnsemblGenome=HelroG185955|UniProtKB=T1FNH3 T1FNH3 20210370 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG163554|UniProtKB=T1EU74 T1EU74 20200124 PTHR13800:SF12 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 ION TRANSPORT DOMAIN-CONTAINING PROTEIN passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG104360|UniProtKB=T1EDL2 T1EDL2 20194664 PTHR23123:SF21 PHD/F-BOX CONTAINING PROTEIN JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 1 protein demethylase activity#GO:0140457;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG173557|UniProtKB=T1F6Z0 T1F6Z0 20204589 PTHR22902:SF9 SESQUIPEDALIAN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184306|UniProtKB=T1FKY3 T1FKY3 20209482 PTHR35711:SF1 EXPRESSED PROTEIN ECTODERMAL, ISOFORM F HELRO|EnsemblGenome=HelroG90918|UniProtKB=T1G7X9 T1G7X9 20217176 PTHR32194:SF0 METALLOPROTEASE TLDD ATP-DEPENDENT PROTEASE SUBUNIT HSLV protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG115827|UniProtKB=T1EGB0 T1EGB0 20195612 PTHR11462:SF60 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cell cycle#GO:0051726;positive regulation of transcription by RNA polymerase II#GO:0045944;response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;response to lipid#GO:0033993;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;response to steroid hormone#GO:0048545;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG114638|UniProtKB=T1EG36 T1EG36 20195538 PTHR12546:SF60 FER-1-LIKE MISFIRE, ISOFORM F cellular process#GO:0009987;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG104248|UniProtKB=T1EDK6 T1EDK6 20194658 PTHR12300:SF161 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG163113|UniProtKB=T1ETN9 T1ETN9 20199939 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG188031|UniProtKB=T1FPK4 T1FPK4 20210751 PTHR23101:SF104 RAB GDP/GTP EXCHANGE FACTOR PROTEIN SPRINT nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899 vesicle#GO:0031982;cytosol#GO:0005829;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG101631|UniProtKB=T1ED61 T1ED61 20194513 PTHR23115:SF188 TRANSLATION FACTOR HBS1-LIKE PROTEIN hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 rescue of stalled cytosolic ribosome#GO:0072344;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;translation#GO:0006412;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;biosynthetic process#GO:0009058;gene expression#GO:0010467;translational elongation#GO:0006414;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 translation factor#PC00223 HELRO|EnsemblGenome=HelroG185729|UniProtKB=T1FN75 T1FN75 20210273 PTHR12192:SF2 CATION TRANSPORT PROTEIN CHAC-RELATED GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2 HELRO|EnsemblGenome=HelroG185098|UniProtKB=T1FME3 T1FME3 20209992 PTHR46002:SF5 EG:114D9.1 PROTEIN-RELATED EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG112693|UniProtKB=T1EFL4 T1EFL4 20195366 PTHR11388:SF162 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG188354|UniProtKB=T1FPW9 T1FPW9 20210866 PTHR24104:SF48 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM71 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG162880|UniProtKB=T1ETB2 T1ETB2 20199812 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191890|UniProtKB=T1FTE2 T1FTE2 20212089 PTHR11586:SF48 TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER AARS-INTERACTING MULTIFUNCTIONAL PROTEIN 1 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 translational protein#PC00263 HELRO|EnsemblGenome=HelroG182087|UniProtKB=T1FHQ1 T1FHQ1 20208350 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86753|UniProtKB=T1G6G5 T1G6G5 20216662 PTHR24033:SF193 EGF-LIKE DOMAIN-CONTAINING PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8 HELRO|EnsemblGenome=HelroG189875|UniProtKB=T1FRF8 T1FRF8 20211405 PTHR24110:SF3 CENTROSOMAL PROTEIN OF 78 KDA CENTROSOMAL PROTEIN OF 78 KDA organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782 microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;centrosome#GO:0005813;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG82280|UniProtKB=T1G4Q2 T1G4Q2 20216050 PTHR23073:SF155 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 6B ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;proteasome complex#GO:0000502;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369 protease#PC00190 Ubiquitin proteasome pathway#P00060>19S proteasome#P01494;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG169179|UniProtKB=T1F1J1 T1F1J1 20202691 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG109161|UniProtKB=T1EEQ7 T1EEQ7 20195059 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;lyase activity#GO:0016829;metal ion binding#GO:0046872 cellular response to stimulus#GO:0051716;hexose biosynthetic process#GO:0019319;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;response to starvation#GO:0042594;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;small molecule biosynthetic process#GO:0044283;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;response to nutrient levels#GO:0031667;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;response to glucose#GO:0009749;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to monosaccharide#GO:0034284;intracellular glucose homeostasis#GO:0001678;response to carbohydrate#GO:0009743;carbohydrate homeostasis#GO:0033500;carboxylic acid metabolic process#GO:0019752;response to hexose#GO:0009746;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;chemical homeostasis#GO:0048878;alcohol metabolic process#GO:0006066;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;cellular response to glucose stimulus#GO:0071333;glucose homeostasis#GO:0042593;glucose metabolic process#GO:0006006;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;gluconeogenesis#GO:0006094;cellular response to oxygen-containing compound#GO:1901701;response to stress#GO:0006950;carbohydrate biosynthetic process#GO:0016051;response to lipid#GO:0033993;response to chemical#GO:0042221 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG170932|UniProtKB=T1F3M0 T1F3M0 20203419 PTHR23107:SF39 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN SS18 N-TERMINAL DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG166931|UniProtKB=T1EYR6 T1EYR6 20201716 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG63233|UniProtKB=T1FXC7 T1FXC7 20213475 PTHR20996:SF1 NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 intracellular anatomical structure#GO:0005622;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;membrane protein complex#GO:0098796 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG68685|UniProtKB=T1FZI3 T1FZI3 20214231 PTHR13355:SF11 GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;glucosamine 6-phosphate N-acetyltransferase activity#GO:0004343 acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG159619|UniProtKB=T1EP90 T1EP90 20198390 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194111|UniProtKB=T1FVP6 T1FVP6 20212892 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG66106|UniProtKB=T1FYH0 T1FYH0 20213868 PTHR13681:SF26 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG183766|UniProtKB=T1FK62 T1FK62 20209211 PTHR10623:SF6 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER EB1, ISOFORM F-RELATED microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;intracellular protein localization#GO:0008104;regulation of microtubule polymerization or depolymerization#GO:0031110;microtubule-based process#GO:0007017;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;cellular process#GO:0009987;cellular component assembly#GO:0022607;protein localization to microtubule cytoskeleton#GO:0072698;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein localization to cytoskeleton#GO:0044380;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule end#GO:1990752;cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188840|UniProtKB=T1FQE9 T1FQE9 20211046 PTHR13793:SF150 PHD FINGER PROTEINS PHD FINGER PROTEIN 14 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168918|UniProtKB=T1F146 T1F146 20202546 PTHR24351:SF234 RIBOSOMAL PROTEIN S6 KINASE SERINE_THREONINE-PROTEIN KINASE YPK2_YKR2 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162124|UniProtKB=T1ES95 T1ES95 20199445 PTHR45901:SF3 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY PLAT DOMAINS 1 HELRO|EnsemblGenome=HelroG85149|UniProtKB=T1G5T4 T1G5T4 20216431 PTHR12644:SF5 ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;cell migration#GO:0016477;actin nucleation#GO:0045010;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Integrin signalling pathway#P00034>Arp2/3#P00912 HELRO|EnsemblGenome=HelroG136387|UniProtKB=T1EID8 T1EID8 20196338 PTHR22978:SF48 B-CELL TRANSLOCATION GENE ANTI-PROLIFERATIVE PROTEIN DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;negative regulation of cell population proliferation#GO:0008285;negative regulation of biological process#GO:0048519 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG73105|UniProtKB=T1G1A2 T1G1A2 20214850 PTHR11831:SF1 30S 40S RIBOSOMAL PROTEIN U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3 RNA binding#GO:0003723;structural molecule activity#GO:0005198;snoRNA binding#GO:0030515;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;binding#GO:0005488 ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG175147|UniProtKB=T1F8X1 T1F8X1 20205270 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG185083|UniProtKB=T1FMD6 T1FMD6 20209985 PTHR46857:SF2 EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE F-BOX ONLY PROTEIN 16 HELRO|EnsemblGenome=HelroG75808|UniProtKB=T1G2A5 T1G2A5 20215203 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG174638|UniProtKB=T1F8C0 T1F8C0 20205069 PTHR23282:SF101 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. RT07201P-RELATED HELRO|EnsemblGenome=HelroG185427|UniProtKB=T1FMT2 T1FMT2 20210131 PTHR10516:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP12 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853 metabolic process#GO:0008152;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;gene expression#GO:0010467;protein maturation#GO:0051604;regulation of muscle contraction#GO:0006937;regulation of biological process#GO:0050789;regulation of muscle system process#GO:0090257;protein folding#GO:0006457;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of system process#GO:0044057;calcium-mediated signaling#GO:0019722;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;regulation of monoatomic ion transport#GO:0043269;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;regulation of transmembrane transport#GO:0034762;regulation of heart contraction#GO:0008016;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG149347|UniProtKB=T1EKC8 T1EKC8 20197028 PTHR11347:SF239 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG113770|UniProtKB=T1EFW2 T1EFW2 20195464 PTHR45702:SF2 ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER ADAM10 ENDOPEPTIDASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;membrane protein ectodomain proteolysis#GO:0006509;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>ADAM10#P00108 HELRO|EnsemblGenome=HelroG109889|UniProtKB=T1EEX1 T1EEX1 20195123 PTHR23323:SF29 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 transport#GO:0006810;lytic vacuole organization#GO:0080171;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;vesicle organization#GO:0016050;endosome organization#GO:0007032;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;lysosome organization#GO:0007040;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;lysosomal transport#GO:0007041;endosome to lysosome transport#GO:0008333;vacuole organization#GO:0007033;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG166059|UniProtKB=T1EXN6 T1EXN6 20201336 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69115|UniProtKB=T1FZP7 T1FZP7 20214295 PTHR21242:SF0 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;peptidase complex#GO:1905368;transferase complex#GO:1990234;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192132|UniProtKB=T1FTM0 T1FTM0 20212167 PTHR22950:SF652 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;amino acid transport#GO:0006865 cellular anatomical structure#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG185570|UniProtKB=T1FMZ6 T1FMZ6 20210195 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED binding#GO:0005488;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;protein binding#GO:0005515 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162691|UniProtKB=T1ET07 T1ET07 20199707 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG91412|UniProtKB=T1G834 T1G834 20217231 PTHR10807:SF134 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 dephosphorylation#GO:0016311;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid dephosphorylation#GO:0046839;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG157615|UniProtKB=T1EME0 T1EME0 20197740 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG189297|UniProtKB=T1FQX6 T1FQX6 20211223 PTHR19282:SF570 TETRASPANIN TETRASPANIN TSPA-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174241|UniProtKB=T1F7V2 T1F7V2 20204901 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG180419|UniProtKB=T1FFW8 T1FFW8 20207717 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG180700|UniProtKB=T1FG67 T1FG67 20207816 PTHR46228:SF2 KELCH DOMAIN-CONTAINING PROTEIN KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350) HELRO|EnsemblGenome=HelroG166934|UniProtKB=T1EYR9 T1EYR9 20201719 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG156323|UniProtKB=T1ELT8 T1ELT8 20197538 PTHR10953:SF4 UBIQUITIN-ACTIVATING ENZYME E1 E1 UBIQUITIN-ACTIVATING ENZYME ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;response to stress#GO:0006950;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG86708|UniProtKB=T1G6F9 T1G6F9 20216656 PTHR24033:SF224 EGF-LIKE DOMAIN-CONTAINING PROTEIN PROTEIN EYES SHUT HELRO|EnsemblGenome=HelroG77791|UniProtKB=T1G340 T1G340 20215488 PTHR14336:SF15 TANDEM PH DOMAIN CONTAINING PROTEIN DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE anion binding#GO:0043168;phospholipid binding#GO:0005543;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG186556|UniProtKB=T1FP11 T1FP11 20210558 PTHR20852:SF57 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE 2 CYTOPLASMIC ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG106514|UniProtKB=T1EE30 T1EE30 20194832 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;response to heat#GO:0009408;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;protein refolding#GO:0042026;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG170233|UniProtKB=T1F2T3 T1F2T3 20203132 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG191292|UniProtKB=T1FSU8 T1FSU8 20211895 PTHR23257:SF994 SERINE-THREONINE PROTEIN KINASE IP11267P phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG163969|UniProtKB=T1EUP4 T1EUP4 20200294 PTHR45995:SF1 FAMILY NOT NAMED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 4 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG100017|UniProtKB=T1ECY1 T1ECY1 20194433 PTHR45806:SF1 SYNAPTOBREVIN HOMOLOG YKT6 SYNAPTOBREVIN HOMOLOG YKT6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 localization#GO:0051179;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;vacuole fusion#GO:0097576;catabolic process#GO:0009056;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;intra-Golgi vesicle-mediated transport#GO:0006891;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;metabolic process#GO:0008152;Golgi vesicle transport#GO:0048193;transport#GO:0006810;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;vacuole fusion, non-autophagic#GO:0042144;macroautophagy#GO:0016236;organelle organization#GO:0006996;membrane fusion#GO:0061025;autophagy#GO:0006914;cellular process#GO:0009987 organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;autophagosome#GO:0005776;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG185364|UniProtKB=T1FMQ4 T1FMQ4 20210103 PTHR42681:SF8 MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161741|UniProtKB=T1ERV1 T1ERV1 20199301 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG137972|UniProtKB=T1EIQ3 T1EIQ3 20196453 PTHR48019:SF248 SERUM RESPONSE FACTOR HOMOLOG SERUM RESPONSE FACTOR HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;MADS box transcription factor#PC00250 PDGF signaling pathway#P00047>SRF#P01165 HELRO|EnsemblGenome=HelroG162885|UniProtKB=T1ETB5 T1ETB5 20199815 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG73484|UniProtKB=T1G1E2 T1G1E2 20214890 PTHR21314:SF0 QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 HELRO|EnsemblGenome=HelroG153281|UniProtKB=T1EL25 T1EL25 20197275 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192560|UniProtKB=T1FU29 T1FU29 20212325 PTHR38537:SF13 JITTERBUG, ISOFORM N JITTERBUG, ISOFORM N HELRO|EnsemblGenome=HelroG186200|UniProtKB=T1FNT2 T1FNT2 20210479 PTHR21737:SF3 POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3 POLYGLUTAMINE-BINDING PROTEIN 1 binding#GO:0005488;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear body#GO:0016604;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164196|UniProtKB=T1EV30 T1EV30 20200430 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG192724|UniProtKB=T1FU82 T1FU82 20212378 PTHR44662:SF1 WD REPEAT-CONTAINING PROTEIN 81 WD REPEAT-CONTAINING PROTEIN 81 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 metabolic process#GO:0008152;cellular process#GO:0009987;autophagy#GO:0006914;catabolic process#GO:0009056;process utilizing autophagic mechanism#GO:0061919;macroautophagy#GO:0016236 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG69169|UniProtKB=T1FZQ4 T1FZQ4 20214302 PTHR13275:SF4 YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Swr1 complex#GO:0000812;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG103160|UniProtKB=T1EDE6 T1EDE6 20194598 PTHR42921:SF1 ACETOACETYL-COA SYNTHETASE ACETOACETYL-COA SYNTHETASE catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG147095|UniProtKB=T1EJW8 T1EJW8 20196868 PTHR11954:SF22 D-DOPACHROME DECARBOXYLASE D-DOPACHROME DECARBOXYLASE catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262;lyase#PC00144 HELRO|EnsemblGenome=HelroG167618|UniProtKB=T1EZK6 T1EZK6 20202006 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG172842|UniProtKB=T1F601 T1F601 20204250 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG146344|UniProtKB=T1EJR8 T1EJR8 20196818 PTHR15314:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P20 RIBONUCLEASE P PROTEIN SUBUNIT P20 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG111587|UniProtKB=T1EFC7 T1EFC7 20195279 PTHR24072:SF100 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOC hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787 response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;cell motility#GO:0048870;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;cell division#GO:0051301;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cell migration#GO:0016477;biological regulation#GO:0065007;mitotic cell cycle process#GO:1903047;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970 cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein#PC00020;small GTPase#PC00208 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Rho#P00860;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>RhoA#P05938;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507;Angiogenesis#P00005>GTPase#P00254;Integrin signalling pathway#P00034>Rho#P00948;Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Ras Pathway#P04393>Rho#P04578;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RhoA#P00740;Axon guidance mediated by semaphorins#P00007>Rho#P00341 HELRO|EnsemblGenome=HelroG136124|UniProtKB=T1EIC2 T1EIC2 20196322 PTHR11106:SF123 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 purine nucleoside metabolic process#GO:0042278;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;purine-containing compound metabolic process#GO:0072521;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;nucleoside metabolic process#GO:0009116;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG83278|UniProtKB=T1G532 T1G532 20216180 PTHR11058:SF26 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 electron transfer activity#GO:0009055;oxidoreductase activity, acting on NAD(P)H#GO:0016651;monoatomic cation transmembrane transporter activity#GO:0008324;NADH dehydrogenase activity#GO:0003954;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG167921|UniProtKB=T1EZY7 T1EZY7 20202137 PTHR21689:SF2 LIN-9 PROTEIN LIN-9 HOMOLOG DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG159887|UniProtKB=T1EPI1 T1EPI1 20198481 PTHR21004:SF0 SERINE PROTEASE-RELATED PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of lipid catabolic process#GO:0050994;regulation of cellular process#GO:0050794;proteolysis#GO:0006508;regulation of lipid metabolic process#GO:0019216;protein metabolic process#GO:0019538 microbody#GO:0042579;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 serine protease#PC00203 HELRO|EnsemblGenome=HelroG62905|UniProtKB=T1FX72 T1FX72 20213420 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG178799|UniProtKB=T1FDR2 T1FDR2 20206961 PTHR21191:SF16 AQUAPORIN AQUAPORIN channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250 regulation of cell size#GO:0008361;regulation of biological quality#GO:0065008;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;regulation of anatomical structure size#GO:0090066;homeostatic process#GO:0042592;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG160285|UniProtKB=T1EQ20 T1EQ20 20198670 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG111100|UniProtKB=T1EF81 T1EF81 20195233 PTHR10694:SF129 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG96242|UniProtKB=T1G9B0 T1G9B0 20217657 PTHR11739:SF8 CITRATE SYNTHASE CITRATE SYNTHASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;cellular process#GO:0009987;tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759 metabolite interconversion enzyme#PC00262;transferase#PC00220 Pyruvate metabolism#P02772>Citrate Synthetase#P03141;TCA cycle#P00051>Citrate Synthase#P01267 HELRO|EnsemblGenome=HelroG185104|UniProtKB=T1FME5 T1FME5 20209994 PTHR10264:SF136 BAND 7 PROTEIN-RELATED BAND 7 DOMAIN-CONTAINING PROTEIN ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG165489|UniProtKB=T1EWW5 T1EWW5 20201065 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194061|UniProtKB=T1FVM8 T1FVM8 20212874 PTHR24203:SF86 ANKYRIN REPEAT FAMILY PROTEIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 15-RELATED HELRO|EnsemblGenome=HelroG185206|UniProtKB=T1FMI3 T1FMI3 20210032 PTHR43888:SF31 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ HOMOLOG SUBFAMILY A MEMBER 2 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;ATPase activator activity#GO:0001671;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 protein metabolic process#GO:0019538;protein refolding#GO:0042026;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;protein folding#GO:0006457;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to stress#GO:0006950;cellular response to heat#GO:0034605;response to heat#GO:0009408;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG79614|UniProtKB=T1G3Q9 T1G3Q9 20215707 PTHR13718:SF61 RIBOSOMAL S SUBUNIT SMALL RIBOSOMAL SUBUNIT PROTEIN US5M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 cytosolic small ribosomal subunit#GO:0022627;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;organelle lumen#GO:0043233;cytosolic ribosome#GO:0022626;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG159828|UniProtKB=T1EPG1 T1EPG1 20198461 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG172077|UniProtKB=T1F502 T1F502 20203901 PTHR22741:SF10 P140CAP/SNIP-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG102919|UniProtKB=T1EDD2 T1EDD2 20194584 PTHR14165:SF3 MAJOR VAULT PROTEIN MAJOR VAULT PROTEIN response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192733|UniProtKB=T1FU87 T1FU87 20212383 PTHR22600:SF59 BETA-HEXOSAMINIDASE BETA-HEXOSAMINIDASE A hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;lysosome#GO:0005764;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;extracellular region#GO:0005576;intracellular organelle#GO:0043229 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG72217|UniProtKB=T1G0X4 T1G0X4 20214722 PTHR42643:SF24 IONOTROPIC RECEPTOR 20A-RELATED IONOTROPIC RECEPTOR 20A-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG116956|UniProtKB=T1EGI8 T1EGI8 20195690 PTHR12993:SF11 N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE deacetylase activity#GO:0019213;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;deacylase activity#GO:0160215 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 deacetylase#PC00087 HELRO|EnsemblGenome=HelroG159950|UniProtKB=T1EPL3 T1EPL3 20198513 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG190791|UniProtKB=T1FSA7 T1FSA7 20211704 PTHR45824:SF32 GH16843P SEC14P-LIKE PHOSPHATIDYLINOSITOL TRANSFER FAMILY PROTEIN HELRO|EnsemblGenome=HelroG159899|UniProtKB=T1EPI8 T1EPI8 20198488 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG97947|UniProtKB=T1G9J7 T1G9J7 20217743 PTHR11700:SF8 30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US10 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG163662|UniProtKB=T1EUB9 T1EUB9 20200169 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185863|UniProtKB=T1FND3 T1FND3 20210330 PTHR12849:SF0 RNA LARIAT DEBRANCHING ENZYME LARIAT DEBRANCHING ENZYME nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;catabolic process#GO:0009056;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG143038|UniProtKB=T1EJ88 T1EJ88 20196638 PTHR24006:SF952 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG175374|UniProtKB=T1F974 T1F974 20205373 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181437|UniProtKB=T1FH03 T1FH03 20208102 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG193555|UniProtKB=T1FV46 T1FV46 20212692 PTHR10394:SF3 40S RIBOSOMAL PROTEIN S8 SMALL RIBOSOMAL SUBUNIT PROTEIN ES8 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG189915|UniProtKB=T1FRH4 T1FRH4 20211421 PTHR15136:SF5 STROMAL INTERACTION MOLECULE HOMOLOG STROMAL INTERACTION MOLECULE HOMOLOG molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246;channel regulator activity#GO:0016247;cation binding#GO:0043169;metal ion binding#GO:0046872;transporter regulator activity#GO:0141108;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;monoatomic ion homeostasis#GO:0050801 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG170417|UniProtKB=T1F312 T1F312 20203211 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175725|UniProtKB=T1F9K8 T1F9K8 20205507 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG94513|UniProtKB=T1G915 T1G915 20217562 PTHR13803:SF4 SEC24-RELATED PROTEIN SECRETORY 24CD, ISOFORM C zinc ion binding#GO:0008270;SNARE binding#GO:0000149;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169 membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;COPII-coated vesicle budding#GO:0090114 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;coated membrane#GO:0048475;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;ER to Golgi transport vesicle membrane#GO:0012507;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG178094|UniProtKB=T1FCQ4 T1FCQ4 20206603 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG181163|UniProtKB=T1FGP4 T1FGP4 20207993 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165725|UniProtKB=T1EX76 T1EX76 20201176 PTHR48620:SF1 TAX1-BINDING PROTEIN 3 TAX1-BINDING PROTEIN 3 HELRO|EnsemblGenome=HelroG94423|UniProtKB=T1G911 T1G911 20217558 PTHR24343:SF457 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE STK11 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG65737|UniProtKB=T1FYC1 T1FYC1 20213819 PTHR20978:SF0 SPLICING FACTOR 3B SUBUNIT 5 SPLICING FACTOR 3B SUBUNIT 5 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG69129|UniProtKB=T1FZQ0 T1FZQ0 20214298 PTHR13069:SF21 ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8 TRNA (CARBOXYMETHYLURIDINE(34)-5-O)-METHYLTRANSFERASE ALKBH8 binding#GO:0005488;nucleic acid binding#GO:0003676;methyltransferase activity#GO:0008168;RNA binding#GO:0003723;catalytic activity, acting on a tRNA#GO:0140101;tRNA binding#GO:0000049;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG190529|UniProtKB=T1FS27 T1FS27 20211624 PTHR15598:SF5 ENHANCER OF MRNA-DECAPPING PROTEIN 4 ENHANCER OF MRNA-DECAPPING PROTEIN 4 molecular condensate scaffold activity#GO:0140693;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;regulation of biological process#GO:0050789;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;RNA decapping#GO:0110154 intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG165283|UniProtKB=T1EWJ2 T1EWJ2 20200942 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166510|UniProtKB=T1EY70 T1EY70 20201520 PTHR10562:SF151 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 1 protein binding#GO:0005515;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein sumoylation#GO:0016925;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;post-translational protein modification#GO:0043687 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 p53 pathway#P00059>Sumo-1 ligase#P04635 HELRO|EnsemblGenome=HelroG117001|UniProtKB=T1EGJ2 T1EGJ2 20195694 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG86038|UniProtKB=T1G663 T1G663 20216560 PTHR11210:SF60 RING BOX RING-BOX PROTEIN 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987 nucleus#GO:0005634;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG80016|UniProtKB=T1G3W5 T1G3W5 20215763 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG194364|UniProtKB=T1FVZ7 T1FVZ7 20212993 PTHR44157:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 11 DNAJ HOMOLOG SUBFAMILY C MEMBER 11 cellular component organization or biogenesis#GO:0071840;mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;membrane organization#GO:0061024 chaperone#PC00072 HELRO|EnsemblGenome=HelroG167167|UniProtKB=T1EZ33 T1EZ33 20201833 PTHR13260:SF0 ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4 ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;protein K11-linked ubiquitination#GO:0070979;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178982|UniProtKB=T1FE04 T1FE04 20207053 PTHR24253:SF201 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG154853|UniProtKB=T1ELG2 T1ELG2 20197412 PTHR24067:SF154 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 G2 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 catabolic process#GO:0009056;response to stimulus#GO:0050896;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;protein modification process#GO:0036211;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Parkinson disease#P00049>Ubc7#P01220 HELRO|EnsemblGenome=HelroG72632|UniProtKB=T1G130 T1G130 20214778 PTHR21641:SF0 TRANSLATION INITIATION FACTOR-RELATED RNA-BINDING PROTEIN EIF1AD-RELATED intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG172462|UniProtKB=T1F5C9 T1F5C9 20204028 PTHR24324:SF5 HOMEOBOX PROTEIN HHEX HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG177338|UniProtKB=T1FBJ1 T1FBJ1 20206190 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG178769|UniProtKB=T1FDP8 T1FDP8 20206947 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG168882|UniProtKB=T1F134 T1F134 20202534 PTHR11604:SF0 PROFILIN PROFILIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin monomer binding#GO:0003785;binding#GO:0005488 cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HELRO|EnsemblGenome=HelroG185332|UniProtKB=T1FMP2 T1FMP2 20210091 PTHR19919:SF0 WD REPEAT CONTAINING PROTEIN DDB1- AND CUL4-ASSOCIATED FACTOR 7 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG85381|UniProtKB=T1G5W2 T1G5W2 20216459 PTHR10468:SF12 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82552|UniProtKB=T1G4T9 T1G4T9 20216087 PTHR24340:SF41 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN CEH-24-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG123698|UniProtKB=T1EGY5 T1EGY5 20195835 PTHR12892:SF17 FGF RECEPTOR ACTIVATING PROTEIN 1 POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;carbohydrate derivative metabolic process#GO:1901135;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organophosphate metabolic process#GO:0019637 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG149039|UniProtKB=T1EKC3 T1EKC3 20197023 PTHR45623:SF62 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED KISMET, ISOFORM C ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;DNA binding#GO:0003677;histone binding#GO:0042393;pyrophosphatase activity#GO:0016462;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111 regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;biological regulation#GO:0065007;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG171438|UniProtKB=T1F4A1 T1F4A1 20203650 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161527|UniProtKB=T1ERL2 T1ERL2 20199212 PTHR12231:SF279 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN ROUNDABOUT 1, ISOFORM A-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;animal gross anatomical part developmental process#GO:0160108;cell recognition#GO:0008037;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;main axon#GO:0044304;neuron projection#GO:0043005;cell projection membrane#GO:0031253;neuron projection membrane#GO:0032589;leading edge membrane#GO:0031256;axon#GO:0030424 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG94015|UniProtKB=T1G8Y5 T1G8Y5 20217532 PTHR43979:SF1 PRE-MRNA-PROCESSING FACTOR 17 PRE-MRNA-PROCESSING FACTOR 17 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG194961|UniProtKB=T1FWL8 T1FWL8 20213213 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG191117|UniProtKB=T1FSL8 T1FSL8 20211815 PTHR24214:SF38 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 developmental process#GO:0032502;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;cellular component organization or biogenesis#GO:0071840;anatomical structure development#GO:0048856;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061 cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;adherens junction#GO:0005912;stress fiber#GO:0001725;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cell-cell junction#GO:0005911;actomyosin#GO:0042641;actin filament bundle#GO:0032432;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG171942|UniProtKB=T1F4V6 T1F4V6 20203855 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162786|UniProtKB=T1ET53 T1ET53 20199753 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN voltage-gated calcium channel activity#GO:0005245;channel regulator activity#GO:0016247;channel activity#GO:0015267;transporter regulator activity#GO:0141108;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 regulation of biological quality#GO:0065008;localization#GO:0051179;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;transmission of nerve impulse#GO:0019226;system process#GO:0003008;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839 voltage-gated ion channel#PC00241;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG172303|UniProtKB=T1F571 T1F571 20203970 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185938|UniProtKB=T1FNG7 T1FNG7 20210364 PTHR12474:SF0 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN HOMOLOG oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;amino acid binding#GO:0016597;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;cation binding#GO:0043169;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;organic acid binding#GO:0043177 response to nitrogen compound#GO:1901698;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to amino acid stimulus#GO:0071230;positive regulation of macroautophagy#GO:0016239;negative regulation of TORC1 signaling#GO:1904262;regulation of macroautophagy#GO:0016241;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;cellular response to oxygen-containing compound#GO:1901701;response to acid chemical#GO:0001101;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;cellular response to amino acid starvation#GO:0034198;response to chemical#GO:0042221;negative regulation of signal transduction#GO:0009968 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185746|UniProtKB=T1FN84 T1FN84 20210282 PTHR13234:SF8 GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT GILT-LIKE PROTEIN F37H8.5 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG177331|UniProtKB=T1FBI4 T1FBI4 20206183 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG82345|UniProtKB=T1G4Q9 T1G4Q9 20216057 PTHR14336:SF15 TANDEM PH DOMAIN CONTAINING PROTEIN DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;anion binding#GO:0043168;phospholipid binding#GO:0005543;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG159053|UniProtKB=T1ENJ3 T1ENJ3 20198143 PTHR14677:SF45 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED AN1-TYPE DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184876|UniProtKB=T1FM42 T1FM42 20209891 PTHR21021:SF16 GAF/PUTATIVE CYTOSKELETAL PROTEIN TIP41-LIKE PROTEIN protein phosphatase regulator activity#GO:0019888;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;enzyme activator activity#GO:0008047 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;TOR signaling#GO:0031929;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG64295|UniProtKB=T1FXS5 T1FXS5 20213623 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell morphogenesis#GO:0000902;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;axonogenesis#GO:0007409;neuron development#GO:0048666;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;positive regulation of transcription by RNA polymerase II#GO:0045944;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell fate specification#GO:0001708;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG190227|UniProtKB=T1FRS7 T1FRS7 20211524 PTHR14130:SF14 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 92B enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG65745|UniProtKB=T1FYC2 T1FYC2 20213820 PTHR21223:SF2 CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary transition zone#GO:0035869;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG184997|UniProtKB=T1FM90 T1FM90 20209939 PTHR12931:SF15 UBIQUITIN THIOLESTERASE PROTEIN OTUB UBIQUITIN THIOESTERASE OTUBAIN-LIKE ubiquitin binding#GO:0043130;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG77501|UniProtKB=T1G2Y7 T1G2Y7 20215435 PTHR13023:SF3 APYRASE SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787 proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 cellular anatomical structure#GO:0110165;membrane#GO:0016020 hydrolase#PC00121;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG171387|UniProtKB=T1F479 T1F479 20203628 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144773|UniProtKB=T1EJG2 T1EJG2 20196712 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378 transferase#PC00220 HELRO|EnsemblGenome=HelroG178095|UniProtKB=T1FCQ5 T1FCQ5 20206604 PTHR33539:SF1 UPF0764 PROTEIN C16ORF89 UPF0764 PROTEIN C16ORF89 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG188393|UniProtKB=T1FPY0 T1FPY0 20210877 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG176907|UniProtKB=T1FB15 T1FB15 20206014 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG161297|UniProtKB=T1ERB1 T1ERB1 20199111 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG170339|UniProtKB=T1F2X8 T1F2X8 20203177 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG186534|UniProtKB=T1FP08 T1FP08 20210555 PTHR14146:SF4 EXOCYST COMPLEX COMPONENT 4 EXOCYST COMPLEX COMPONENT 4 export from cell#GO:0140352;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;secretion by cell#GO:0032940;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;synaptic signaling#GO:0099536;exocytosis#GO:0006887;establishment of localization#GO:0051234;transport#GO:0006810 cell junction#GO:0030054;vesicle tethering complex#GO:0099023;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;exocyst#GO:0000145;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;axon#GO:0030424;growth cone#GO:0030426;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cell cortex#GO:0005938 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG82658|UniProtKB=T1G4U9 T1G4U9 20216097 PTHR22984:SF33 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG184865|UniProtKB=T1FM35 T1FM35 20209884 PTHR11952:SF20 UDP- GLUCOSE PYROPHOSPHORYLASE UDP-N-ACETYLGLUCOSAMINE DIPHOSPHORYLASE transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-sugar metabolic process#GO:0009225;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;UDP-N-acetylglucosamine metabolic process#GO:0006047;organophosphate biosynthetic process#GO:0090407 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG161397|UniProtKB=T1ERF8 T1ERF8 20199158 PTHR11444:SF1 ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE FUMARATE HYDRATASE, MITOCHONDRIAL hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 generation of precursor metabolites and energy#GO:0006091;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;tricarboxylic acid cycle#GO:0006099;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 lyase#PC00144 TCA cycle#P00051>Fumarase#P01271 HELRO|EnsemblGenome=HelroG178502|UniProtKB=T1FD99 T1FD99 20206798 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG87443|UniProtKB=T1G6Q1 T1G6Q1 20216748 PTHR42799:SF2 MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to oxidative stress#GO:0034599;response to stimulus#GO:0050896;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;reductase#PC00198 HELRO|EnsemblGenome=HelroG95099|UniProtKB=T1G945 T1G945 20217592 PTHR16007:SF15 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B-LIKE HELRO|EnsemblGenome=HelroG167146|UniProtKB=T1EZ27 T1EZ27 20201827 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG156780|UniProtKB=T1EM10 T1EM10 20197610 PTHR10061:SF0 S-FORMYLGLUTATHIONE HYDROLASE S-FORMYLGLUTATHIONE HYDROLASE hydrolase activity#GO:0016787;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG160208|UniProtKB=T1EPZ3 T1EPZ3 20198643 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163691|UniProtKB=T1EUD0 T1EUD0 20200180 PTHR24072:SF192 RHO FAMILY GTPASE CDC42 HOMOLOG protein binding#GO:0005515;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cell communication#GO:0007154;localization#GO:0051179;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein#PC00020;small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;Integrin signalling pathway#P00034>Cdc42#P00938;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;Ras Pathway#P04393>Cdc42#P04569;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Cdc42#P00515;p38 MAPK pathway#P05918>Cdc42#P06041;Axon guidance mediated by netrin#P00009>cdc42#P00364;FGF signaling pathway#P00021>Rac#P00645;Axon guidance mediated by Slit/Robo#P00008>Cdc42#P00349 HELRO|EnsemblGenome=HelroG177427|UniProtKB=T1FBP1 T1FBP1 20206240 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190944|UniProtKB=T1FSG1 T1FSG1 20211758 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG156203|UniProtKB=T1ELS6 T1ELS6 20197526 PTHR33588:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 structural protein#PC00211 HELRO|EnsemblGenome=HelroG191850|UniProtKB=T1FTC6 T1FTC6 20212073 PTHR23407:SF6 ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE ATPASE INHIBITOR, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515 porphyrin-containing compound metabolic process#GO:0006778;developmental process#GO:0032502;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;multicellular organismal-level homeostasis#GO:0048871;cellular developmental process#GO:0048869;cellular process#GO:0009987;pigment metabolic process#GO:0042440;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;tetrahydrofolate biosynthetic process#GO:0046654;homeostasis of number of cells#GO:0048872;tetrapyrrole metabolic process#GO:0033013;immune system process#GO:0002376;tetrahydrofolate metabolic process#GO:0046653;erythrocyte differentiation#GO:0030218;anatomical structure development#GO:0048856;porphyrin-containing compound biosynthetic process#GO:0006779;modified amino acid metabolic process#GO:0006575;heme biosynthetic process#GO:0006783;cell development#GO:0048468;homeostatic process#GO:0042592;myeloid cell differentiation#GO:0030099;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;tetrapyrrole biosynthetic process#GO:0033014 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ligase#PC00142 HELRO|EnsemblGenome=HelroG156659|UniProtKB=T1ELZ6 T1ELZ6 20197596 PTHR11592:SF144 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to oxidative stress#GO:0034599;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193180|UniProtKB=T1FUP9 T1FUP9 20212545 PTHR23074:SF83 AAA DOMAIN-CONTAINING VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;intracellular transport#GO:0046907;transport#GO:0006810;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;ubiquitin-dependent protein catabolic process#GO:0006511;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;localization#GO:0051179;cellular localization#GO:0051641;protein metabolic process#GO:0019538;vacuole organization#GO:0007033;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG161570|UniProtKB=T1ERM6 T1ERM6 20199226 PTHR13327:SF0 NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161733|UniProtKB=T1ERU7 T1ERU7 20199297 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG134516|UniProtKB=T1EI51 T1EI51 20196251 PTHR11462:SF60 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;response to steroid hormone#GO:0048545;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;response to lipid#GO:0033993;positive regulation of transcription by RNA polymerase II#GO:0045944 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG109869|UniProtKB=T1EEX0 T1EEX0 20195122 PTHR21646:SF14 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITINYL HYDROLASE 1 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG194191|UniProtKB=T1FVS3 T1FVS3 20212919 PTHR11214:SF314 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG154743|UniProtKB=T1ELF8 T1ELF8 20197408 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177392|UniProtKB=T1FBL9 T1FBL9 20206218 PTHR11875:SF49 TESTIS-SPECIFIC Y-ENCODED PROTEIN PROTEIN SET protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG81219|UniProtKB=T1G4B4 T1G4B4 20215912 PTHR46321:SF1 KIF1-BINDING PROTEIN KIF-BINDING PROTEIN developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;central nervous system neuron differentiation#GO:0021953;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;central nervous system development#GO:0007417;cell projection organization#GO:0030030;cell differentiation#GO:0030154;neuron projection organization#GO:0106027;cell morphogenesis#GO:0000902;cell development#GO:0048468 HELRO|EnsemblGenome=HelroG191577|UniProtKB=T1FT35 T1FT35 20211982 PTHR24388:SF86 ZINC FINGER PROTEIN BTB DOMAIN-CONTAINING PROTEIN double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG69055|UniProtKB=T1FZN8 T1FZN8 20214286 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169437|UniProtKB=T1F1X8 T1F1X8 20202828 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190567|UniProtKB=T1FS35 T1FS35 20211632 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG152911|UniProtKB=T1EKY1 T1EKY1 20197231 PTHR21196:SF1 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10 RNA binding#GO:0003723;snRNA binding#GO:0017069;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;nucleoplasm#GO:0005654;organelle#GO:0043226;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080 HELRO|EnsemblGenome=HelroG77420|UniProtKB=T1G2X3 T1G2X3 20215421 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular process#GO:0009987;regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;transport#GO:0006810;regulation of secretion#GO:0051046;localization#GO:0051179;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG169837|UniProtKB=T1F2D1 T1F2D1 20202981 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG184653|UniProtKB=T1FLP3 T1FLP3 20209742 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112831|UniProtKB=T1EFM4 T1EFM4 20195376 PTHR24031:SF84 RNA HELICASE EUKARYOTIC INITIATION FACTOR 4A biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183 membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular protein-containing complex#GO:0140535;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG177869|UniProtKB=T1FCE3 T1FCE3 20206492 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG76352|UniProtKB=T1G2I8 T1G2I8 20215286 PTHR21230:SF102 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;protein binding#GO:0005515;SNAP receptor activity#GO:0005484 establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;membrane organization#GO:0061024;macroautophagy#GO:0016236;retrograde transport, endosome to Golgi#GO:0042147;membrane fusion#GO:0061025;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;vesicle fusion#GO:0006906;catabolic process#GO:0009056;Golgi organization#GO:0007030;intra-Golgi vesicle-mediated transport#GO:0006891;endosomal transport#GO:0016197;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;metabolic process#GO:0008152;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;post-Golgi vesicle-mediated transport#GO:0006892;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;cytosolic transport#GO:0016482;cellular component organization#GO:0016043 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;membrane#GO:0016020;vesicle membrane#GO:0012506;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;COPII-coated ER to Golgi transport vesicle#GO:0030134;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708 SNARE protein#PC00034;membrane traffic protein#PC00150 Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042 HELRO|EnsemblGenome=HelroG113500|UniProtKB=T1EFT0 T1EFT0 20195432 PTHR45623:SF60 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED DNA HELICASE hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;ATP-dependent activity, acting on DNA#GO:0008094;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;hydrolase activity#GO:0016787;DNA binding#GO:0003677;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;histone binding#GO:0042393;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG106158|UniProtKB=T1EE05 T1EE05 20194807 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG163573|UniProtKB=T1EU82 T1EU82 20200132 PTHR21541:SF3 BTB POZ DOMAIN CONTAINING 12 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4 cell cycle#GO:0007049;cellular component organization#GO:0016043;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;homologous recombination#GO:0035825;reproductive process#GO:0022414;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;organelle fission#GO:0048285;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG73348|UniProtKB=T1G1C9 T1G1C9 20214877 PTHR18945:SF856 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG174318|UniProtKB=T1F7Z7 T1F7Z7 20204946 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164080|UniProtKB=T1EUW2 T1EUW2 20200362 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG63527|UniProtKB=T1FXH0 T1FXH0 20213518 PTHR14005:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;cytoplasmic translational initiation#GO:0002183;translation#GO:0006412;translational initiation#GO:0006413;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG167827|UniProtKB=T1EZU6 T1EZU6 20202096 PTHR43591:SF24 METHYLTRANSFERASE METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;catalytic activity#GO:0003824;transferase activity#GO:0016740 methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG185576|UniProtKB=T1FMZ9 T1FMZ9 20210198 PTHR47385:SF14 CALPONIN TRANSGELIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG188008|UniProtKB=T1FPJ5 T1FPJ5 20210742 PTHR15907:SF161 DUF614 FAMILY PROTEIN-RELATED DUF614 DOMAIN PROTEIN HELRO|EnsemblGenome=HelroG87168|UniProtKB=T1G6M7 T1G6M7 20216724 PTHR10972:SF205 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 1 steroid binding#GO:0005496;lipid binding#GO:0008289;sterol binding#GO:0032934;binding#GO:0005488 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG194346|UniProtKB=T1FVY6 T1FVY6 20212982 PTHR24412:SF172 KELCH PROTEIN KELCH-LIKE PROTEIN 10 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91729|UniProtKB=T1G882 T1G882 20217279 PTHR13354:SF12 ROUND SPERMATID BASIC PROTEIN 1 LYSINE-SPECIFIC DEMETHYLASE 9 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;oxidoreductase activity#GO:0016491;protein demethylase activity#GO:0140457;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG156370|UniProtKB=T1ELU6 T1ELU6 20197546 PTHR10804:SF11 PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P PROLIFERATION-ASSOCIATED PROTEIN 2G4 protease#PC00190 HELRO|EnsemblGenome=HelroG63014|UniProtKB=T1FX98 T1FX98 20213446 PTHR45987:SF29 39S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG192125|UniProtKB=T1FTL6 T1FTL6 20212163 PTHR22950:SF652 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;L-amino acid transmembrane transporter activity#GO:0015179 localization#GO:0051179;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transport#GO:0006865;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HELRO|EnsemblGenome=HelroG84839|UniProtKB=T1G5P5 T1G5P5 20216392 PTHR28605:SF1 CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE) CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG78404|UniProtKB=T1G3B4 T1G3B4 20215562 PTHR11178:SF1 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG167602|UniProtKB=T1EZJ3 T1EZJ3 20201993 PTHR22770:SF47 UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF216 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;regulation of localization#GO:0032879;regulation of transport#GO:0051049;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627 synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;presynapse#GO:0098793;postsynapse#GO:0098794;intracellular protein-containing complex#GO:0140535;cell junction#GO:0030054;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177369|UniProtKB=T1FBK7 T1FBK7 20206206 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG192968|UniProtKB=T1FUG8 T1FUG8 20212464 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 transferase#PC00220 HELRO|EnsemblGenome=HelroG95727|UniProtKB=T1G971 T1G971 20217618 PTHR10177:SF615 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-A cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cellular process#GO:0009987;cell cycle process#GO:0022402;mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;protein kinase complex#GO:1902911;membraneless organelle#GO:0043228;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG168983|UniProtKB=T1F180 T1F180 20202580 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 10 HELRO|EnsemblGenome=HelroG104383|UniProtKB=T1EDL3 T1EDL3 20194665 PTHR46315:SF1 SPERMINE SYNTHASE SPERMINE SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;polyamine metabolic process#GO:0006595;amine metabolic process#GO:0009308;metabolic process#GO:0008152;biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;polyamine biosynthetic process#GO:0006596 HELRO|EnsemblGenome=HelroG184938|UniProtKB=T1FM67 T1FM67 20209916 PTHR10256:SF0 SELENIDE, WATER DIKINASE INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179563|UniProtKB=T1FEV6 T1FEV6 20207355 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG119394|UniProtKB=T1EGN1 T1EGN1 20195731 PTHR11946:SF93 VALYL-TRNA SYNTHETASES VALINE--TRNA LIGASE-RELATED ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG186288|UniProtKB=T1FNX4 T1FNX4 20210521 PTHR24089:SF736 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL COENZYME A TRANSPORTER SLC25A42 nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nitrogen compound transport#GO:0071705;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG155958|UniProtKB=T1ELP6 T1ELP6 20197496 PTHR45928:SF1 RE38146P RE38146P HELRO|EnsemblGenome=HelroG76730|UniProtKB=T1G2N6 T1G2N6 20215334 PTHR24291:SF201 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 oxidoreductase#PC00176;oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG180732|UniProtKB=T1FG78 T1FG78 20207827 PTHR43725:SF32 UDP-GLUCOSE 4-EPIMERASE NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853 small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 epimerase/racemase#PC00096 HELRO|EnsemblGenome=HelroG194686|UniProtKB=T1FWB5 T1FWB5 20213111 PTHR23220:SF122 INTEGRIN ALPHA INTEGRIN ALPHA-PS1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609 membrane#GO:0016020;membrane protein complex#GO:0098796;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG164612|UniProtKB=T1EVN0 T1EVN0 20200630 PTHR22793:SF12 MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG164083|UniProtKB=T1EUW5 T1EUW5 20200365 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75258|UniProtKB=T1G231 T1G231 20215129 PTHR11575:SF50 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;ribonucleotide metabolic process#GO:0009259;purine nucleotide catabolic process#GO:0006195;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine ribonucleotide catabolic process#GO:0009154;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261 membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG158730|UniProtKB=T1EN59 T1EN59 20198009 PTHR12400:SF51 INOSITOL POLYPHOSPHATE KINASE INOSITOL POLYPHOSPHATE MULTIKINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate biosynthetic process#GO:0090407;small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 kinase#PC00137 HELRO|EnsemblGenome=HelroG124434|UniProtKB=T1EH13 T1EH13 20195863 PTHR43489:SF6 ISOMERASE HYDROXYPYRUVATE ISOMERASE-RELATED intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861 cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;glyoxylate metabolic process#GO:0046487;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;isomerase#PC00135 HELRO|EnsemblGenome=HelroG122048|UniProtKB=T1EGT7 T1EGT7 20195787 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG183999|UniProtKB=T1FKE6 T1FKE6 20209295 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;plasma membrane#GO:0005886;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;late endosome membrane#GO:0031902;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HELRO|EnsemblGenome=HelroG162708|UniProtKB=T1ET15 T1ET15 20199715 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174587|UniProtKB=T1F8A0 T1F8A0 20205049 PTHR14369:SF0 SURFEIT LOCUS PROTEIN 6 SURFEIT LOCUS PROTEIN 6 RNA binding#GO:0003723;molecular condensate scaffold activity#GO:0140693;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;nucleic acid binding#GO:0003676;binding#GO:0005488 ribosomal small subunit biogenesis#GO:0042274;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG195043|UniProtKB=T1FWP5 T1FWP5 20213240 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG186070|UniProtKB=T1FNM6 T1FNM6 20210423 PTHR43184:SF31 MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;phosphate transmembrane transporter activity#GO:0005315 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG65955|UniProtKB=T1FYE9 T1FYE9 20213847 PTHR10625:SF36 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 3 catalytic activity, acting on a protein#GO:0140096;deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824 regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;chromatin organization#GO:0006325;biological regulation#GO:0065007;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233 Wnt signaling pathway#P00057>Histone deacetylase#P01472 HELRO|EnsemblGenome=HelroG99809|UniProtKB=T1G9V3 T1G9V3 20217849 PTHR11485:SF29 TRANSFERRIN TRANSFERRIN 2 transport#GO:0006810;transition metal ion transport#GO:0000041;iron ion transport#GO:0006826;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;metal ion transport#GO:0030001 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG72755|UniProtKB=T1G149 T1G149 20214797 PTHR33447:SF2 GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755 metabolic process#GO:0008152;response to cadmium ion#GO:0046686;response to metal ion#GO:0010038;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;biosynthetic process#GO:0009058;detoxification#GO:0098754;cellular response to chemical stimulus#GO:0070887;cellular detoxification#GO:1990748;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to toxic substance#GO:0009636;response to stimulus#GO:0050896 HELRO|EnsemblGenome=HelroG96284|UniProtKB=T1G9B1 T1G9B1 20217658 PTHR24393:SF190 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG191051|UniProtKB=T1FSJ6 T1FSJ6 20211793 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191647|UniProtKB=T1FT62 T1FT62 20212009 PTHR11040:SF223 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG70078|UniProtKB=T1G024 T1G024 20214422 PTHR10352:SF83 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FI04408P regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG74273|UniProtKB=T1G1P2 T1G1P2 20214990 PTHR21392:SF0 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2 HELRO|EnsemblGenome=HelroG150937|UniProtKB=T1EKH9 T1EKH9 20197079 PTHR10410:SF51 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED BRCA1_BRCA2-CONTAINING COMPLEX SUBUNIT 3 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG193403|UniProtKB=T1FUY7 T1FUY7 20212633 PTHR45861:SF1 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT DNA POLYMERASE ALPHA CATALYTIC SUBUNIT single-stranded DNA binding#GO:0003697;binding#GO:0005488;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;transferase activity#GO:0016740;DNA-directed DNA polymerase activity#GO:0003887;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA-templated DNA replication#GO:0006261 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;replisome#GO:0030894;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 DNA replication#P00017>Pol alpha#P00531 HELRO|EnsemblGenome=HelroG84705|UniProtKB=T1G5M6 T1G5M6 20216373 PTHR16719:SF0 CYTOCHROME C OXIDASE COPPER CHAPERONE CYTOCHROME C OXIDASE COPPER CHAPERONE molecular carrier activity#GO:0140104 cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004 intracellular organelle#GO:0043229;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 HELRO|EnsemblGenome=HelroG102536|UniProtKB=T1EDA2 T1EDA2 20194554 PTHR21727:SF0 PHOSPHORYLATED CTD INTERACTING FACTOR 1 MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG96328|UniProtKB=T1G9B4 T1G9B4 20217661 PTHR24092:SF5 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE intramembrane lipid carrier activity#GO:0140303;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215 transport#GO:0006810;Golgi vesicle transport#GO:0048193;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;macromolecule localization#GO:0033036;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;lipid transport#GO:0006869;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179;cellular component organization#GO:0016043;lipid translocation#GO:0034204;endocytosis#GO:0006897;organophosphate ester transport#GO:0015748 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG72073|UniProtKB=T1G0V1 T1G0V1 20214699 PTHR12681:SF0 ZINC FINGER-CONTAINING PROTEIN P48ZNF ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG87691|UniProtKB=T1G6U4 T1G6U4 20216791 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG157415|UniProtKB=T1EMB1 T1EMB1 20197711 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094 transport#GO:0006810;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133 HELRO|EnsemblGenome=HelroG177855|UniProtKB=T1FCD5 T1FCD5 20206484 PTHR46545:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51 cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG175920|UniProtKB=T1F9W2 T1F9W2 20205611 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175226|UniProtKB=T1F916 T1F916 20205315 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71107|UniProtKB=T1G0G7 T1G0G7 20214565 PTHR19305:SF14 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED binding#GO:0005488;molecular adaptor activity#GO:0060090;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;protein binding#GO:0005515 synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;membrane fusion#GO:0061025;synaptic vesicle membrane organization#GO:0048499;biological regulation#GO:0065007;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;synaptic vesicle fusion to presynaptic active zone membrane#GO:0031629;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;vesicle fusion#GO:0006906;anterograde trans-synaptic signaling#GO:0098916;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;vesicle fusion to plasma membrane#GO:0099500;exocytosis#GO:0006887;protein-containing complex organization#GO:0043933;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;secretion by cell#GO:0032940;cellular localization#GO:0051641;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;export from cell#GO:0140352;signaling#GO:0023052 protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Synaptic vesicle trafficking#P05734>SNAP-25#P05778;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049 HELRO|EnsemblGenome=HelroG185745|UniProtKB=T1FN83 T1FN83 20210281 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Cell cycle#P00013>Protein kinase subunit#P00482;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035 HELRO|EnsemblGenome=HelroG185222|UniProtKB=T1FMI9 T1FMI9 20210038 PTHR12771:SF74 ENGULFMENT AND CELL MOTILITY CED-12 actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG119222|UniProtKB=T1EGM6 T1EGM6 20195726 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672 positive regulation of cellular process#GO:0048522;ERBB signaling pathway#GO:0038127;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;neurogenesis#GO:0022008;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;nervous system development#GO:0007399;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;positive regulation of cell population proliferation#GO:0008284;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG188361|UniProtKB=T1FPX2 T1FPX2 20210869 PTHR14215:SF0 PROTEIN OF UNKNOWN FUNCTION DUF729 MITOCHONDRIAL FISSION REGULATOR 2 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;organelle fission#GO:0048285;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;cellular component organization or biogenesis#GO:0071840;aerobic respiration#GO:0009060;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;mitochondrial fission#GO:0000266;mitochondrion organization#GO:0007005 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179672|UniProtKB=T1FF05 T1FF05 20207404 PTHR14605:SF1 CHST5 PROTEIN TRANSMEMBRANE PROTEIN 231 cellular component organization#GO:0016043;cilium assembly#GO:0060271;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;organelle assembly#GO:0070925;regulation of protein localization#GO:0032880;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;regulation of localization#GO:0032879 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;ciliary membrane#GO:0060170;plasma membrane region#GO:0098590;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;ciliary transition zone#GO:0035869;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell projection membrane#GO:0031253 HELRO|EnsemblGenome=HelroG185802|UniProtKB=T1FNB1 T1FNB1 20210308 PTHR10551:SF9 FASCIN FASCIN-2 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cell migration#GO:0016477;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cellular component organization#GO:0016043;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;supramolecular fiber organization#GO:0097435;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG186205|UniProtKB=T1FNT3 T1FNT3 20210480 PTHR13439:SF0 CT120 PROTEIN TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4 lipid homeostasis#GO:0055088;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG170146|UniProtKB=T1F2Q0 T1F2Q0 20203099 PTHR43827:SF13 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN reductase#PC00198 HELRO|EnsemblGenome=HelroG123115|UniProtKB=T1EGW9 T1EGW9 20195819 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG105890|UniProtKB=T1EDY3 T1EDY3 20194785 PTHR42908:SF6 TRANSLATION ELONGATION FACTOR-RELATED 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleic acid binding#GO:0003676;GTPase activity#GO:0003924;snRNA binding#GO:0017069;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746;ribonucleoside triphosphate phosphatase activity#GO:0017111 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;protein biosynthetic process#GO:0160307;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;translational elongation#GO:0006414;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytosol#GO:0005829;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG153328|UniProtKB=T1EL40 T1EL40 20197290 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177781|UniProtKB=T1FC91 T1FC91 20206440 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG160398|UniProtKB=T1EQ74 T1EQ74 20198724 PTHR21237:SF23 GRPE PROTEIN GRPE PROTEIN HOMOLOG, MITOCHONDRIAL enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG156148|UniProtKB=T1ELS0 T1ELS0 20197520 PTHR23430:SF50 HISTONE H2A HISTONE H2A structural molecule activity#GO:0005198 negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG175531|UniProtKB=T1F9D0 T1F9D0 20205429 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176546|UniProtKB=T1FAM9 T1FAM9 20205878 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG177722|UniProtKB=T1FC47 T1FC47 20206396 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG83199|UniProtKB=T1G519 T1G519 20216167 PTHR24073:SF1234 DRAB5-RELATED RAB32, ISOFORM B hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036 Golgi apparatus subcompartment#GO:0098791;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG110599|UniProtKB=T1EF34 T1EF34 20195186 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488 nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG177365|UniProtKB=T1FBK4 T1FBK4 20206203 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG180404|UniProtKB=T1FFV9 T1FFV9 20207708 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110936|UniProtKB=T1EF64 T1EF64 20195216 PTHR43261:SF9 TRANSLATION ELONGATION FACTOR G-RELATED RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;mitochondrial gene expression#GO:0140053;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;translation#GO:0006412;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 translation elongation factor#PC00222;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG186232|UniProtKB=T1FNU6 T1FNU6 20210493 PTHR10229:SF0 GTP-BINDING PROTEIN HFLX GTP-BINDING PROTEIN 6-RELATED protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG176480|UniProtKB=T1FAK1 T1FAK1 20205850 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG173004|UniProtKB=T1F695 T1F695 20204344 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163248|UniProtKB=T1ETU2 T1ETU2 20199992 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191958|UniProtKB=T1FTG2 T1FTG2 20212109 PTHR46165:SF7 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 MYND-TYPE DOMAIN-CONTAINING PROTEIN enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG185762|UniProtKB=T1FN93 T1FN93 20210291 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG91406|UniProtKB=T1G833 T1G833 20217230 PTHR46107:SF3 DUMPY: SHORTER THAN WILD-TYPE THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 1 disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG106408|UniProtKB=T1EE25 T1EE25 20194827 PTHR19376:SF72 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG160127|UniProtKB=T1EPU4 T1EPU4 20198594 PTHR21041:SF17 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE DCST1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;single fertilization#GO:0007338;reproductive process#GO:0022414;fertilization#GO:0009566;cell recognition#GO:0008037;sexual reproduction#GO:0019953;sperm-egg recognition#GO:0035036;cell-cell recognition#GO:0009988 vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG165464|UniProtKB=T1EWU5 T1EWU5 20201045 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192453|UniProtKB=T1FTZ4 T1FTZ4 20212291 PTHR12585:SF27 SCC1 / RAD21 FAMILY MEMBER MEIOTIC RECOMBINATION PROTEIN REC8 HOMOLOG binding#GO:0005488;chromatin binding#GO:0003682 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;sister chromatid cohesion#GO:0007062;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cohesin complex#GO:0008278;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157558|UniProtKB=T1EMD1 T1EMD1 20197731 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG186826|UniProtKB=T1FP39 T1FP39 20210586 PTHR24351:SF216 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190625|UniProtKB=T1FS54 T1FS54 20211651 PTHR31247:SF5 TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER TRANSMEMBRANE PROTEIN 198 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG172296|UniProtKB=T1F568 T1F568 20203967 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110801|UniProtKB=T1EF52 T1EF52 20195204 PTHR11849:SF195 ETS GA-BINDING PROTEIN ALPHA CHAIN DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG89291|UniProtKB=T1G7B6 T1G7B6 20216963 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;metal ion transmembrane transporter activity#GO:0046873;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803 metal ion transport#GO:0030001;membrane depolarization#GO:0051899;action potential#GO:0001508;sodium ion transport#GO:0006814;sensory perception of pain#GO:0019233;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;sensory perception#GO:0007600;nervous system process#GO:0050877;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;system process#GO:0003008;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;sodium channel complex#GO:0034706 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG181618|UniProtKB=T1FH65 T1FH65 20208164 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179281|UniProtKB=T1FEH2 T1FEH2 20207221 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94060|UniProtKB=T1G8Y8 T1G8Y8 20217535 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB ion channel regulator activity#GO:0099106;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG183486|UniProtKB=T1FJR1 T1FJR1 20209060 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169705|UniProtKB=T1F290 T1F290 20202940 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG95985|UniProtKB=T1G997 T1G997 20217644 PTHR11773:SF1 GLYCINE DEHYDROGENASE, DECARBOXYLATING GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG110454|UniProtKB=T1EF22 T1EF22 20195174 PTHR22884:SF498 SET DOMAIN PROTEINS NUCLEAR RECEPTOR BINDING SET DOMAIN PROTEIN catalytic activity, acting on a protein#GO:0140096;histone H3K36 methyltransferase activity#GO:0046975;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG183772|UniProtKB=T1FK63 T1FK63 20209212 PTHR11256:SF64 BCL-2 RELATED AT16536P channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;signaling#GO:0023052 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 HELRO|EnsemblGenome=HelroG184272|UniProtKB=T1FKW3 T1FKW3 20209462 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG75608|UniProtKB=T1G273 T1G273 20215171 PTHR24349:SF179 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 5 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;enzyme binding#GO:0019899;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;mitogen-activated protein kinase binding#GO:0051019;kinase activity#GO:0016301;transferase activity#GO:0016740;calmodulin binding#GO:0005516 Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG189400|UniProtKB=T1FR10 T1FR10 20211257 PTHR14633:SF3 LITTLE ELONGATION COMPLEX SUBUNIT 2 LITTLE ELONGATION COMPLEX SUBUNIT 2 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;snRNA transcription#GO:0009301;transcription by RNA polymerase III#GO:0006383;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;transcription by RNA polymerase II#GO:0006366;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;snRNA transcription by RNA polymerase III#GO:0042796;snRNA metabolic process#GO:0016073;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;snRNA transcription by RNA polymerase II#GO:0042795;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG137725|UniProtKB=T1EIM9 T1EIM9 20196429 PTHR11829:SF380 FORKHEAD BOX PROTEIN PROTEIN FORK HEAD sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG189109|UniProtKB=T1FQN8 T1FQN8 20211135 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG108777|UniProtKB=T1EEM3 T1EEM3 20195025 PTHR11006:SF10 PROTEIN ARGININE N-METHYLTRANSFERASE HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG87627|UniProtKB=T1G6T2 T1G6T2 20216779 PTHR12211:SF3 ENDOPLASMIC RETICULUM PROTEIN ERP29 PROTEIN WINDBEUTEL binding#GO:0005488;protein-folding chaperone binding#GO:0051087;protein binding#GO:0005515 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68163|UniProtKB=T1FZB1 T1FZB1 20214159 PTHR12419:SF122 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 5 catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of TORC1 signaling#GO:1903432;positive regulation of TORC1 signaling#GO:1904263;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG84503|UniProtKB=T1G5J3 T1G5J3 20216340 PTHR24346:SF51 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of glycogen biosynthetic process#GO:0005979;negative regulation of cellular process#GO:0048523;regulation of carbohydrate metabolic process#GO:0006109;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of polysaccharide metabolic process#GO:0032881;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of carbohydrate biosynthetic process#GO:0043255;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG87912|UniProtKB=T1G6W7 T1G6W7 20216814 PTHR22895:SF9 ARMADILLO REPEAT-CONTAINING PROTEIN 6 ARMADILLO REPEAT-CONTAINING PROTEIN 6 hemopoiesis#GO:0030097;cell development#GO:0048468;cell differentiation#GO:0030154;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG174304|UniProtKB=T1F7Z2 T1F7Z2 20204941 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162115|UniProtKB=T1ES91 T1ES91 20199441 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG161732|UniProtKB=T1ERU6 T1ERU6 20199296 PTHR47537:SF6 CUBILIN CUB DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG98414|UniProtKB=T1G9M5 T1G9M5 20217771 PTHR24031:SF301 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX18 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG104662|UniProtKB=T1EDM8 T1EDM8 20194680 PTHR12096:SF0 NUCLEAR PROTEIN SKIP-RELATED SNW DOMAIN-CONTAINING PROTEIN 1 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG73187|UniProtKB=T1G1B4 T1G1B4 20214862 PTHR12716:SF8 TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;transcription factor binding#GO:0008134;binding#GO:0005488 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIE#P00666;General transcription regulation#P00023>TFIIEbeta#P00659;Transcription regulation by bZIP transcription factor#P00055>TFIIEbeta#P01386;Transcription regulation by bZIP transcription factor#P00055>TFIIE#P01395 HELRO|EnsemblGenome=HelroG65392|UniProtKB=T1FY71 T1FY71 20213769 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG111950|UniProtKB=T1EFF9 T1EFF9 20195311 PTHR13872:SF49 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;protein modification process#GO:0036211;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG172153|UniProtKB=T1F527 T1F527 20203926 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172980|UniProtKB=T1F687 T1F687 20204336 PTHR10030:SF37 ALPHA-L-FUCOSIDASE TISSUE ALPHA-L-FUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;glycosyl compound catabolic process#GO:1901658 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG106717|UniProtKB=T1EE42 T1EE42 20194844 PTHR13045:SF0 5'-NUCLEOTIDASE 7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 esterase#PC00097;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178737|UniProtKB=T1FDN2 T1FDN2 20206931 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR TITIN tyrosine protein kinase receptor#PC00233;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG62433|UniProtKB=T1FX06 T1FX06 20213354 PTHR45618:SF69 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 7 proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324 homeostatic process#GO:0042592;response to stimulus#GO:0050896;mitochondrial transport#GO:0006839;response to cold#GO:0009409;response to abiotic stimulus#GO:0009628;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;adaptive thermogenesis#GO:1990845;mitochondrial transmembrane transport#GO:1990542;response to temperature stimulus#GO:0009266;multicellular organismal process#GO:0032501;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;response to stress#GO:0006950;multicellular organismal-level homeostasis#GO:0048871;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;temperature homeostasis#GO:0001659 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG75631|UniProtKB=T1G279 T1G279 20215177 PTHR23255:SF71 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE BABO catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;molecular transducer activity#GO:0060089;transferase activity#GO:0016740;activin binding#GO:0048185;kinase activity#GO:0016301;signaling receptor activity#GO:0038023;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877 biological regulation#GO:0065007;nervous system development#GO:0007399;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;activin receptor signaling pathway#GO:0032924;animal gross anatomical part developmental process#GO:0160108 transferase complex, transferring phosphorus-containing groups#GO:0061695;signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 Activin beta signaling pathway#P06210>BABO#P06231;MYO signaling pathway#P06215>BABO#P06310;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;ALP23B signaling pathway#P06209>BABO#P06220;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442 HELRO|EnsemblGenome=HelroG182101|UniProtKB=T1FHR2 T1FHR2 20208361 PTHR21490:SF2 ENKURIN-RELATED ENKURIN DOMAIN-CONTAINING PROTEIN 1 cytoplasmic microtubule#GO:0005881;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874 HELRO|EnsemblGenome=HelroG163460|UniProtKB=T1EU28 T1EU28 20200078 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67454|UniProtKB=T1FZ11 T1FZ11 20214059 PTHR12756:SF4 CYTOSOLIC CARBOXYPEPTIDASE PEPTIDASE M14 DOMAIN-CONTAINING PROTEIN metallopeptidase activity#GO:0008237;binding#GO:0005488;carboxypeptidase activity#GO:0004180;protein binding#GO:0005515;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metalloexopeptidase activity#GO:0008235;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG189012|UniProtKB=T1FQK1 T1FQK1 20211098 PTHR31518:SF3 ARGININE/SERINE-RICH PROTEIN PNISR ARGININE_SERINE-RICH PROTEIN PNISR HELRO|EnsemblGenome=HelroG78428|UniProtKB=T1G3B6 T1G3B6 20215564 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG76748|UniProtKB=T1G2N9 T1G2N9 20215337 PTHR21052:SF0 SPERMATOGENESIS ASSOCIATED 11-RELATED RNA DEMETHYLASE ALKBH7, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;dioxygenase activity#GO:0051213 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG177552|UniProtKB=T1FBV4 T1FBV4 20206303 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161792|UniProtKB=T1ERX3 T1ERX3 20199323 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG192580|UniProtKB=T1FU33 T1FU33 20212329 PTHR13381:SF0 RNA POLYMERASE II HOLOENZYME COMPONENT SRB7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG64498|UniProtKB=T1FXV5 T1FXV5 20213653 PTHR12934:SF15 50S RIBOSOMAL PROTEIN L15 LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG82832|UniProtKB=T1G4X1 T1G4X1 20216119 PTHR46161:SF1 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE 5 transferase#PC00220;kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HELRO|EnsemblGenome=HelroG68124|UniProtKB=T1FZA6 T1FZA6 20214154 PTHR10218:SF212 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA S SUBUNIT ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;response to oxygen-containing compound#GO:1901700;nervous system process#GO:0050877;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;G protein-coupled dopamine receptor signaling pathway#GO:0007212;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;sensory perception of chemical stimulus#GO:0007606;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008 cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Endothelin signaling pathway#P00019>Gs#P00584;Enkephalin release#P05913>G-Protein (s)#P05977 HELRO|EnsemblGenome=HelroG75640|UniProtKB=T1G281 T1G281 20215179 PTHR14189:SF0 PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED PROTEIN PHOSPHATASE METHYLESTERASE 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185768|UniProtKB=T1FN96 T1FN96 20210294 PTHR19375:SF184 HEAT SHOCK PROTEIN 70KDA STRESS-70 PROTEIN, MITOCHONDRIAL hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;protein refolding#GO:0042026;protein metabolic process#GO:0019538;protein folding#GO:0006457;iron-sulfur cluster assembly#GO:0016226;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chaperone#PC00072;Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG177918|UniProtKB=T1FCG8 T1FCG8 20206517 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188505|UniProtKB=T1FQ24 T1FQ24 20210921 PTHR11955:SF135 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, MUSCLE lipid binding#GO:0008289;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167 lipid transport#GO:0006869;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;lipid localization#GO:0010876 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG157956|UniProtKB=T1EMI1 T1EMI1 20197781 PTHR12411:SF1051 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN F catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG192012|UniProtKB=T1FTI3 T1FTI3 20212130 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG72771|UniProtKB=T1G154 T1G154 20214802 PTHR28672:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein K11-linked ubiquitination#GO:0070979;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG161895|UniProtKB=T1ES03 T1ES03 20199353 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190832|UniProtKB=T1FSC2 T1FSC2 20211719 PTHR12988:SF6 SPHINGOMYELIN PHOSPHODIESTERASE 4 SPHINGOMYELIN PHOSPHODIESTERASE 4 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569 ceramide metabolic process#GO:0006672;organophosphate catabolic process#GO:0046434;glycerolipid catabolic process#GO:0046503;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;phosphorus metabolic process#GO:0006793;glycerophospholipid catabolic process#GO:0046475;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;sphingomyelin metabolic process#GO:0006684;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG186248|UniProtKB=T1FNV1 T1FNV1 20210498 PTHR12507:SF3 REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED RAB6A-GEF COMPLEX PARTNER PROTEIN 2 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 HELRO|EnsemblGenome=HelroG81288|UniProtKB=T1G4C6 T1G4C6 20215924 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transmembrane transport#GO:0055085;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG164165|UniProtKB=T1EV11 T1EV11 20200411 PTHR47537:SF6 CUBILIN CUB DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG177885|UniProtKB=T1FCF1 T1FCF1 20206500 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175098|UniProtKB=T1F8U5 T1F8U5 20205244 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81998|UniProtKB=T1G4L5 T1G4L5 20216013 PTHR12143:SF45 PEPTIDE N-GLYCANASE PNGASE -RELATED PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;positive regulation of response to stimulus#GO:0048584;glycoprotein metabolic process#GO:0009100;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of BMP signaling pathway#GO:0030513;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG180917|UniProtKB=T1FGE9 T1FGE9 20207898 PTHR45749:SF44 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1 HELRO|EnsemblGenome=HelroG167246|UniProtKB=T1EZ62 T1EZ62 20201862 PTHR24012:SF897 RNA BINDING PROTEIN RNA-BINDING PROTEIN 42 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG75683|UniProtKB=T1G288 T1G288 20215186 PTHR11387:SF2 CYTOCHROME C OXIDASE SUBUNIT 6B CYTOCHROME C OXIDASE SUBUNIT 6B1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164182|UniProtKB=T1EV21 T1EV21 20200421 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG104126|UniProtKB=T1EDJ7 T1EDJ7 20194649 PTHR22883:SF466 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC4 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;protein targeting#GO:0006605;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG93271|UniProtKB=T1G8U7 T1G8U7 20217494 PTHR11482:SF6 ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE ORNITHINE DECARBOXYLASE 1-RELATED ornithine decarboxylase activity#GO:0004586;lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 polyamine biosynthetic process#GO:0006596;biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;amine metabolic process#GO:0009308;metabolic process#GO:0008152;cellular process#GO:0009987;polyamine metabolic process#GO:0006595 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;decarboxylase#PC00089 Ornithine degradation#P02758>Ornithine decarboxylase#P03053 HELRO|EnsemblGenome=HelroG191819|UniProtKB=T1FTC3 T1FTC3 20212070 PTHR23220:SF133 INTEGRIN ALPHA INTEGRIN ALPHA-PS2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell surface receptor signaling pathway#GO:0007166;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG161987|UniProtKB=T1ES45 T1ES45 20199395 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stress#GO:0006950;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG161577|UniProtKB=T1ERN0 T1ERN0 20199230 PTHR10199:SF119 THROMBOSPONDIN RE20510P extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG71174|UniProtKB=T1G0H4 T1G0H4 20214572 PTHR11616:SF338 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370 sodium ion transport#GO:0006814;carboxylic acid transmembrane transport#GO:1905039;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;glycine transport#GO:0015816;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;nitrogen compound transport#GO:0071705;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;import into cell#GO:0098657;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG66455|UniProtKB=T1FYL3 T1FYL3 20213911 PTHR21680:SF0 COILED-COIL DOMAIN-CONTAINING PROTEIN 124 COILED-COIL DOMAIN-CONTAINING PROTEIN 124 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165686|UniProtKB=T1EX62 T1EX62 20201162 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174255|UniProtKB=T1F7W4 T1F7W4 20204913 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG181133|UniProtKB=T1FGN3 T1FGN3 20207982 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG181010|UniProtKB=T1FGI7 T1FGI7 20207936 PTHR13041:SF3 JTB PROTEIN-RELATED PROTEIN JTB cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;cell division#GO:0051301;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;mitotic cytokinesis#GO:0000281 midbody#GO:0030496;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG80596|UniProtKB=T1G425 T1G425 20215823 PTHR12308:SF84 ANOCTAMIN ANOCTAMIN molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;intramembrane lipid carrier activity#GO:0140303 lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;phospholipid transport#GO:0015914;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188887|UniProtKB=T1FQF8 T1FQF8 20211055 PTHR22923:SF124 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG79613|UniProtKB=T1G3Q8 T1G3Q8 20215706 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG82977|UniProtKB=T1G4Y7 T1G4Y7 20216135 PTHR42884:SF39 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 1 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;proteolysis#GO:0006508;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;peptide hormone processing#GO:0016486;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;neuron projection#GO:0043005;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 serine protease#PC00203 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG159849|UniProtKB=T1EPG9 T1EPG9 20198469 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG135400|UniProtKB=T1EI87 T1EI87 20196287 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;positive regulation of cell cycle#GO:0045787;regulation of reproductive process#GO:2000241;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle process#GO:1903047;positive regulation of mitotic cell cycle#GO:0045931;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;positive regulation of cell cycle process#GO:0090068;regulation of meiotic cell cycle#GO:0051445;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic cell cycle phase transition#GO:0044772 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG177336|UniProtKB=T1FBI9 T1FBI9 20206188 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of neurogenesis#GO:0050767;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;pattern specification process#GO:0007389;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG182112|UniProtKB=T1FHS0 T1FHS0 20208369 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167075|UniProtKB=T1EYZ4 T1EYZ4 20201794 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG177005|UniProtKB=T1FB46 T1FB46 20206045 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG181665|UniProtKB=T1FH78 T1FH78 20208177 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165535|UniProtKB=T1EWZ3 T1EWZ3 20201093 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71674|UniProtKB=T1G0Q1 T1G0Q1 20214649 PTHR13410:SF9 PROTEIN PBDC1 PROTEIN PBDC1 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 HELRO|EnsemblGenome=HelroG85035|UniProtKB=T1G5R6 T1G5R6 20216413 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metallopeptidase activity#GO:0008237;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 primary metabolic process#GO:0044238;cellular process#GO:0009987;peptide catabolic process#GO:0043171;catabolic process#GO:0009056;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG159578|UniProtKB=T1EP66 T1EP66 20198366 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG178644|UniProtKB=T1FDH7 T1FDH7 20206876 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158265|UniProtKB=T1EML3 T1EML3 20197813 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;termination of RNA polymerase II transcription#GO:0006369;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193429|UniProtKB=T1FUZ2 T1FUZ2 20212638 PTHR22600:SF65 BETA-HEXOSAMINIDASE BETA-N-ACETYLHEXOSAMINIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;glycosaminoglycan metabolic process#GO:0030203;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 intracellular organelle#GO:0043229;extracellular region#GO:0005576;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG167678|UniProtKB=T1EZN7 T1EZN7 20202037 PTHR22605:SF26 RZ-TYPE DOMAIN-CONTAINING PROTEIN RZ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190078|UniProtKB=T1FRN8 T1FRN8 20211485 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG177964|UniProtKB=T1FCJ0 T1FCJ0 20206539 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG164223|UniProtKB=T1EV43 T1EV43 20200443 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157743|UniProtKB=T1EMF3 T1EMF3 20197753 PTHR47992:SF257 PROTEIN PHOSPHATASE ALPHABET, ISOFORM E protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of cellular response to stress#GO:0080135;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 protein modifying enzyme#PC00260;protein phosphatase#PC00195 DPP signaling pathway#P06213>PPM1A#P06289;Activin beta signaling pathway#P06210>PPM1A#P06237;MYO signaling pathway#P06215>PPM1A#P06317;SCW signaling pathway#P06216>PPM1A#P06332;BMP/activin signaling pathway-drosophila#P06211>PPM1A#P06247;GBB signaling pathway#P06214>PPM1A#P06296;ALP23B signaling pathway#P06209>PPM1A#P06226;DPP-SCW signaling pathway#P06212>PPM1A#P06261 HELRO|EnsemblGenome=HelroG64880|UniProtKB=T1FY06 T1FY06 20213704 PTHR16290:SF0 TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1 DECAPPING PROTEIN 1, ISOFORM A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA decapping#GO:0110154;RNA catabolic process#GO:0006401;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 mRNA capping factor#PC00145;RNA processing factor#PC00147 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG67701|UniProtKB=T1FZ42 T1FZ42 20214090 PTHR13929:SF17 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 menaquinone biosynthetic process#GO:0009234;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ketone metabolic process#GO:0042180;vitamin K metabolic process#GO:0042373;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152 transferase#PC00220 HELRO|EnsemblGenome=HelroG71557|UniProtKB=T1G0N3 T1G0N3 20214631 PTHR10953:SF5 UBIQUITIN-ACTIVATING ENZYME E1 SUMO-ACTIVATING ENZYME SUBUNIT 2 catalytic activity, acting on a protein#GO:0140096;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877 protein sumoylation#GO:0016925;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG114688|UniProtKB=T1EG40 T1EG40 20195542 PTHR13195:SF0 PSEUDOURIDINE SYNTHASE-RELATED PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 positive regulation of protein metabolic process#GO:0051247;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;mRNA modification#GO:0016556;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;macromolecule modification#GO:0043412;positive regulation of biosynthetic process#GO:0009891;positive regulation of translation#GO:0045727;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139 mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 lyase#PC00144 HELRO|EnsemblGenome=HelroG188705|UniProtKB=T1FQA0 T1FQA0 20210997 PTHR14234:SF19 RIM BINDING PROTEIN-RELATED RIM-BINDING PROTEIN, ISOFORM F scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182167|UniProtKB=T1FHU9 T1FHU9 20208398 PTHR10794:SF98 ABHYDROLASE DOMAIN-CONTAINING PROTEIN ALPHA_BETA HYDROLASE 1, ISOFORM A hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824 monocarboxylic acid biosynthetic process#GO:0072330;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid catabolic process#GO:0072329;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG182778|UniProtKB=T1FIQ1 T1FIQ1 20208700 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG73271|UniProtKB=T1G1C4 T1G1C4 20214872 PTHR45677:SF10 GLUTAMATE DECARBOXYLASE-RELATED GLUTAMATE DECARBOXYLASE carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829 biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HELRO|EnsemblGenome=HelroG193459|UniProtKB=T1FV05 T1FV05 20212651 PTHR11200:SF310 INOSITOL 5-PHOSPHATASE LD06095P catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 ruffle#GO:0001726;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG194255|UniProtKB=T1FVV5 T1FVV5 20212951 PTHR10634:SF67 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 3 HELRO|EnsemblGenome=HelroG177817|UniProtKB=T1FCB5 T1FCB5 20206464 PTHR43591:SF109 METHYLTRANSFERASE METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG149935|UniProtKB=T1EKD9 T1EKD9 20197039 PTHR11909:SF520 CASEIN KINASE-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263 membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>Casein kinase I#P01242;Wnt signaling pathway#P00057>Casein Kinase 1#P01460 HELRO|EnsemblGenome=HelroG191152|UniProtKB=T1FSN5 T1FSN5 20211832 PTHR24270:SF69 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG194556|UniProtKB=T1FW70 T1FW70 20213066 PTHR48057:SF31 LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1 LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of cellular response to stress#GO:0080135;negative regulation of intracellular signal transduction#GO:1902532;cellular localization#GO:0051641;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;establishment of organelle localization#GO:0051656;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;regulation of apoptotic process#GO:0042981;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;negative regulation of signal transduction#GO:0009968;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;organelle localization#GO:0051640;localization#GO:0051179;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;transport#GO:0006810;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;establishment of localization#GO:0051234;vesicle localization#GO:0051648;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171192|UniProtKB=T1F3X2 T1F3X2 20203521 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN binding#GO:0005488;hormone binding#GO:0042562;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG182241|UniProtKB=T1FHZ4 T1FHZ4 20208443 PTHR11481:SF60 IMMUNOGLOBULIN FC RECEPTOR IG-LIKE DOMAIN-CONTAINING PROTEIN plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG173514|UniProtKB=T1F6X1 T1F6X1 20204570 PTHR10884:SF17 NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG84128|UniProtKB=T1G5F0 T1G5F0 20216297 PTHR10933:SF9 IMMUNOGLOBULIN-BINDING PROTEIN 1 IMMUNOGLOBULIN BINDING PROTEIN 1 molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG73507|UniProtKB=T1G1F0 T1G1F0 20214898 PTHR11693:SF45 ATP SYNTHASE GAMMA CHAIN ATP SYNTHASE F(1) COMPLEX SUBUNIT GAMMA, MITOCHONDRIAL channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;purine nucleoside triphosphate biosynthetic process#GO:0009145;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate biosynthetic process#GO:1901293 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ATP synthase#PC00002 ATP synthesis#P02721>F1 gamma#P02796 HELRO|EnsemblGenome=HelroG167577|UniProtKB=T1EZI5 T1EZI5 20201985 PTHR31701:SF3 ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG193921|UniProtKB=T1FVH2 T1FVH2 20212818 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG193156|UniProtKB=T1FUP0 T1FUP0 20212536 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;cellular process#GO:0009987;peptide catabolic process#GO:0043171;catabolic process#GO:0009056;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG177334|UniProtKB=T1FBI7 T1FBI7 20206186 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;anterior/posterior pattern specification#GO:0009952;multicellular organism development#GO:0007275;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG182120|UniProtKB=T1FHS4 T1FHS4 20208373 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG191884|UniProtKB=T1FTD9 T1FTD9 20212086 PTHR22625:SF44 PLEXIN IPT_TIG DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;synapse assembly#GO:0007416;response to stimulus#GO:0050896;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;positive regulation of axonogenesis#GO:0050772;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;positive regulation of cell development#GO:0010720;cellular component assembly#GO:0022607;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular component biogenesis#GO:0044085;regulation of axonogenesis#GO:0050770;regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;system development#GO:0048731;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of cell projection organization#GO:0031346;synapse organization#GO:0050808;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;negative regulation of cell adhesion#GO:0007162;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190892|UniProtKB=T1FSE3 T1FSE3 20211740 PTHR15129:SF0 SRC-ASSOCIATED ADAPTOR PROTEIN SH3 DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72662|UniProtKB=T1G135 T1G135 20214783 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER FIBROPELLIN-1-LIKE signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG77994|UniProtKB=T1G363 T1G363 20215511 PTHR24070:SF459 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP1 pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular response to nitrogen compound#GO:1901699;intracellular signal transduction#GO:0035556;regulation of exocytosis#GO:0017157;response to nitrogen compound#GO:1901698;regulation of secretion#GO:0051046;cell communication#GO:0007154;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;cellular response to stimulus#GO:0051716;regulation of localization#GO:0032879;regulation of transport#GO:0051049;intracellular signaling cassette#GO:0141124;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;regulation of secretion by cell#GO:1903530;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;regulation of neurotransmitter transport#GO:0051588;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;regulation of neurotransmitter secretion#GO:0046928;response to stimulus#GO:0050896;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HELRO|EnsemblGenome=HelroG168250|UniProtKB=T1F0C8 T1F0C8 20202278 PTHR45862:SF1 PROTEIN SGT1 HOMOLOG PROTEIN SGT1 HOMOLOG HELRO|EnsemblGenome=HelroG165183|UniProtKB=T1EWE3 T1EWE3 20200893 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED INHIBITOR 1, PUTATIVE-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG110475|UniProtKB=T1EF25 T1EF25 20195177 PTHR24416:SF647 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cell migration#GO:0016477;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185311|UniProtKB=T1FMN3 T1FMN3 20210082 PTHR12000:SF57 HEMOGLOBINASE FAMILY MEMBER LEGUMAIN cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG174771|UniProtKB=T1F8G3 T1F8G3 20205112 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN syntaxin binding#GO:0019905;molecular function activator activity#GO:0140677;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;binding#GO:0005488;molecular function regulator activity#GO:0098772;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;SNARE binding#GO:0000149;enzyme activator activity#GO:0008047;myosin binding#GO:0017022 regulation of response to stimulus#GO:0048583;transport#GO:0006810;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;establishment of spindle localization#GO:0051293;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;localization within membrane#GO:0051668;actin filament-based process#GO:0030029;regulation of Notch signaling pathway#GO:0008593;cortical cytoskeleton organization#GO:0030865;organelle localization#GO:0051640;localization#GO:0051179;cortical actin cytoskeleton organization#GO:0030866;microtubule cytoskeleton organization#GO:0000226;secretion#GO:0046903;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049;regulation of cell communication#GO:0010646;Golgi to plasma membrane transport#GO:0006893;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;Golgi vesicle transport#GO:0048193;exocytosis#GO:0006887;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;cellular component organization or biogenesis#GO:0071840;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192;regulation of establishment or maintenance of cell polarity#GO:0032878;regulation of signaling#GO:0023051;establishment or maintenance of cell polarity#GO:0007163;post-Golgi vesicle-mediated transport#GO:0006892;secretion by cell#GO:0032940;cellular localization#GO:0051641;spindle localization#GO:0051653;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cellular component organization#GO:0016043;export from cell#GO:0140352;establishment of organelle localization#GO:0051656 cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG66289|UniProtKB=T1FYJ3 T1FYJ3 20213891 PTHR23300:SF0 METHANETHIOL OXIDASE METHANETHIOL OXIDASE defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG173320|UniProtKB=T1F6P0 T1F6P0 20204489 PTHR23107:SF33 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN F-BAR DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG83983|UniProtKB=T1G5C6 T1G5C6 20216273 PTHR14274:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 8 SMALL INTEGRAL MEMBRANE PROTEIN 8 HELRO|EnsemblGenome=HelroG180468|UniProtKB=T1FFY7 T1FFY7 20207736 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75620|UniProtKB=T1G275 T1G275 20215173 PTHR12121:SF37 CARBON CATABOLITE REPRESSOR PROTEIN 4 2',5'-PHOSPHODIESTERASE 12 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG176802|UniProtKB=T1FAX4 T1FAX4 20205973 PTHR46763:SF2 DYNEIN REGULATORY COMPLEX PROTEIN 8 DYNEIN REGULATORY COMPLEX PROTEIN 8 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG96341|UniProtKB=T1G9B5 T1G9B5 20217662 PTHR11851:SF149 METALLOPROTEASE MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT BETA metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;peptidase complex#GO:1905368;membrane-enclosed lumen#GO:0031974;endopeptidase complex#GO:1905369 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG183483|UniProtKB=T1FJR0 T1FJR0 20209059 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115552|UniProtKB=T1EG91 T1EG91 20195593 PTHR11525:SF23 FARNESYL-PYROPHOSPHATE SYNTHETASE FARNESYL PYROPHOSPHATE SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 isoprenoid metabolic process#GO:0006720;organophosphate biosynthetic process#GO:0090407;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;terpenoid metabolic process#GO:0006721;metabolic process#GO:0008152;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;terpenoid biosynthetic process#GO:0016114;cellular process#GO:0009987;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;acyltransferase#PC00042 Cholesterol biosynthesis#P00014>Geranyl trans-transferase#P00493 HELRO|EnsemblGenome=HelroG168368|UniProtKB=T1F0H6 T1F0H6 20202326 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG182049|UniProtKB=T1FHN3 T1FHN3 20208332 PTHR19282:SF570 TETRASPANIN TETRASPANIN TSPA-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174476|UniProtKB=T1F859 T1F859 20205008 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD LICD_FKTN_FKRP NUCLEOTIDYLTRANSFERASE DOMAIN-CONTAINING PROTEIN transferase#PC00220 HELRO|EnsemblGenome=HelroG116156|UniProtKB=T1EGD4 T1EGD4 20195636 PTHR10629:SF61 CYTOSINE-SPECIFIC METHYLTRANSFERASE DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741 cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009;DNA methyltransferase#PC00013 HELRO|EnsemblGenome=HelroG167610|UniProtKB=T1EZJ9 T1EZJ9 20201999 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG190294|UniProtKB=T1FRV5 T1FRV5 20211552 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG192044|UniProtKB=T1FTJ4 T1FTJ4 20212141 PTHR46636:SF1 CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1 CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843;cell cycle#GO:0007049 HELRO|EnsemblGenome=HelroG91608|UniProtKB=T1G860 T1G860 20217257 PTHR21297:SF0 DNA-DIRECTED RNA POLYMERASE II DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 binding#GO:0005488;protein binding#GO:0005515;translation initiation factor binding#GO:0031369 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG124681|UniProtKB=T1EH25 T1EH25 20195875 PTHR22599:SF21 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 2 kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG189136|UniProtKB=T1FQP9 T1FQP9 20211146 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG78187|UniProtKB=T1G391 T1G391 20215539 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE lyase activity#GO:0016829;molecular transducer activity#GO:0060089;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG191046|UniProtKB=T1FSJ3 T1FSJ3 20211790 PTHR24346:SF122 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG101195|UniProtKB=T1ED35 T1ED35 20194487 PTHR11915:SF447 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 actin filament-based process#GO:0030029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036 cell junction#GO:0030054;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG137404|UniProtKB=T1EIK4 T1EIK4 20196404 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG193594|UniProtKB=T1FV55 T1FV55 20212701 PTHR46448:SF5 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175314|UniProtKB=T1F949 T1F949 20205348 PTHR23003:SF71 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nuclear mRNA surveillance#GO:0071028;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA catabolic process#GO:0006402;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG193305|UniProtKB=T1FUV1 T1FUV1 20212597 PTHR12972:SF0 DOWNSTREAM NEIGHBOR OF SON PROTEIN DOWNSTREAM NEIGHBOR OF SON nuclear DNA replication#GO:0033260;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cell cycle DNA replication#GO:0044786;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;DNA replication#GO:0006260;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182098|UniProtKB=T1FHQ9 T1FHQ9 20208358 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG177916|UniProtKB=T1FCG7 T1FCG7 20206516 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155825|UniProtKB=T1ELM9 T1ELM9 20197479 PTHR10218:SF362 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA O SUBUNIT hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid prodynorphin pathway#P05916>G-protein#P06002;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085 HELRO|EnsemblGenome=HelroG92299|UniProtKB=T1G8D9 T1G8D9 20217336 PTHR34593:SF13 MATING RESPONSE PROTEIN POI2 SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG185182|UniProtKB=T1FMH3 T1FMH3 20210022 PTHR10333:SF113 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 5 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG175028|UniProtKB=T1F8Q9 T1F8Q9 20205208 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG85470|UniProtKB=T1G5X5 T1G5X5 20216472 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG92366|UniProtKB=T1G8F1 T1G8F1 20217348 PTHR24083:SF54 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR78 transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG106710|UniProtKB=T1EE39 T1EE39 20194841 PTHR10183:SF437 CALPAIN CALPAIN-5 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG168577|UniProtKB=T1F0R3 T1F0R3 20202413 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG91570|UniProtKB=T1G857 T1G857 20217254 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;steroid metabolic process#GO:0008202;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG72072|UniProtKB=T1G0V0 T1G0V0 20214698 PTHR12984:SF3 SCY1-RELATED S/T PROTEIN KINASE-LIKE N-TERMINAL KINASE-LIKE PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG102915|UniProtKB=T1EDD0 T1EDD0 20194582 PTHR17039:SF0 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 small-subunit processome#GO:0032040;90S preribosome#GO:0030686;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161303|UniProtKB=T1ERB5 T1ERB5 20199115 PTHR15657:SF1 THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26 THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG89947|UniProtKB=T1G7J4 T1G7J4 20217041 PTHR23253:SF9 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2 translation initiation factor activity#GO:0003743;RNA binding#GO:0003723;translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG179329|UniProtKB=T1FEK2 T1FEK2 20207251 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191296|UniProtKB=T1FSU9 T1FSU9 20211896 PTHR13556:SF2 TRANSCRIPTIONAL ADAPTER 3-RELATED TRANSCRIPTIONAL ADAPTER 3 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SAGA-type complex#GO:0070461;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG86763|UniProtKB=T1G6G6 T1G6G6 20216663 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG188901|UniProtKB=T1FQG5 T1FQG5 20211062 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG75979|UniProtKB=T1G2D4 T1G2D4 20215232 PTHR45723:SF5 SERINE/THREONINE-PROTEIN KINASE RIO1 SERINE_THREONINE-PROTEIN KINASE RIO1 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;preribosome#GO:0030684;cytosol#GO:0005829;ribonucleoprotein complex#GO:1990904 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193969|UniProtKB=T1FVI7 T1FVI7 20212833 PTHR23382:SF34 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;pyridine-containing compound metabolic process#GO:0072524;oxoacid metabolic process#GO:0043436;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 dehydrogenase#PC00092 TCA cycle#P00051>Malate Dehydrogenase#P01270 HELRO|EnsemblGenome=HelroG186281|UniProtKB=T1FNW8 T1FNW8 20210515 PTHR24189:SF69 MYOTROPHIN MYOTROPHIN regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of protein-containing complex disassembly#GO:0043244;regulation of protein depolymerization#GO:1901879;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament depolymerization#GO:0030834;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG175493|UniProtKB=T1F9B8 T1F9B8 20205417 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91450|UniProtKB=T1G839 T1G839 20217236 PTHR24416:SF525 TYROSINE-PROTEIN KINASE RECEPTOR INSULIN-LIKE RECEPTOR transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096 positive regulation of signaling#GO:0023056;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;carbohydrate homeostasis#GO:0033500;response to endogenous stimulus#GO:0009719;glucose homeostasis#GO:0042593;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;chemical homeostasis#GO:0048878;response to chemical#GO:0042221;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to hormone#GO:0009725;response to nitrogen compound#GO:1901698;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;homeostatic process#GO:0042592;regulation of cell communication#GO:0010646;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of MAPK cascade#GO:0043410;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cellular response to insulin stimulus#GO:0032869;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;positive regulation of response to stimulus#GO:0048584;cellular response to nitrogen compound#GO:1901699;positive regulation of cellular process#GO:0048522 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transferase complex#GO:1990234;protein kinase complex#GO:1902911;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;transferase complex, transferring phosphorus-containing groups#GO:0061695;axon#GO:0030424;catalytic complex#GO:1902494 transmembrane signal receptor#PC00197 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>INSR IGF-R IRR#P00895;PI3 kinase pathway#P00048>IR#P01187;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>INSR IGF-R IRR#P00885 HELRO|EnsemblGenome=HelroG81167|UniProtKB=T1G4A5 T1G4A5 20215903 PTHR11533:SF294 PROTEASE M1 ZINC METALLOPROTEASE THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME metallopeptidase activity#GO:0008237;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 catabolic process#GO:0009056;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG87916|UniProtKB=T1G6W9 T1G6W9 20216816 PTHR10210:SF53 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER GH23275P enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG80653|UniProtKB=T1G435 T1G435 20215833 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG123829|UniProtKB=T1EGZ2 T1EGZ2 20195842 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 cell projection membrane#GO:0031253;leading edge membrane#GO:0031256;neuron projection membrane#GO:0032589;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG194964|UniProtKB=T1FWM0 T1FWM0 20213215 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG167516|UniProtKB=T1EZG0 T1EZG0 20201960 PTHR13593:SF113 FAMILY NOT NAMED PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 HELRO|EnsemblGenome=HelroG71576|UniProtKB=T1G0N8 T1G0N8 20214636 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG188401|UniProtKB=T1FPY4 T1FPY4 20210881 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG83835|UniProtKB=T1G5A9 T1G5A9 20216256 PTHR10762:SF1 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1 protein modification process#GO:0036211;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG82008|UniProtKB=T1G4L8 T1G4L8 20216016 PTHR13976:SF25 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED RNA-BINDING PROTEIN FUSILLI RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG161906|UniProtKB=T1ES10 T1ES10 20199360 PTHR22906:SF58 PROPERDIN SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164066|UniProtKB=T1EUV2 T1EUV2 20200352 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG134015|UniProtKB=T1EI31 T1EI31 20196231 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FI18312P1 phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180902|UniProtKB=T1FGE3 T1FGE3 20207892 PTHR22902:SF9 SESQUIPEDALIAN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG182743|UniProtKB=T1FIN8 T1FIN8 20208687 PTHR10252:SF153 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ISWI-type complex#GO:0031010;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG157349|UniProtKB=T1EMA0 T1EMA0 20197700 PTHR11827:SF103 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;potassium ion transmembrane transporter activity#GO:0015079;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;monoatomic anion transport#GO:0006820;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG158430|UniProtKB=T1EMS2 T1EMS2 20197872 PTHR45848:SF4 DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG189580|UniProtKB=T1FR61 T1FR61 20211308 PTHR46753:SF3 FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181542|UniProtKB=T1FH32 T1FH32 20208131 PTHR22765:SF405 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GOLIATH transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191983|UniProtKB=T1FTH5 T1FTH5 20212122 PTHR15138:SF14 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;Huntington disease#P00029>TAFII130#P00806;General transcription regulation#P00023>TBP-associated factors#P00658 HELRO|EnsemblGenome=HelroG193420|UniProtKB=T1FUZ0 T1FUZ0 20212636 PTHR45990:SF1 DNA REPAIR PROTEIN REV1 TRANSLESION SYNTHESIS PROTEIN REV1 catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;DNA-directed DNA polymerase activity#GO:0003887 translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;DNA synthesis involved in DNA replication#GO:0090592;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromosome#GO:0005694;site of double-strand break#GO:0035861;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG169137|UniProtKB=T1F1G2 T1F1G2 20202662 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190235|UniProtKB=T1FRT0 T1FRT0 20211527 PTHR46697:SF1 FORMIN-BINDING PROTEIN 4 FORMIN-BINDING PROTEIN 4 HELRO|EnsemblGenome=HelroG73781|UniProtKB=T1G1I3 T1G1I3 20214931 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 cell adhesion#GO:0007155;receptor clustering#GO:0043113;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;signaling#GO:0023052;protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;localization within membrane#GO:0051668;establishment or maintenance of bipolar cell polarity#GO:0061245;protein localization to cell junction#GO:1902414;establishment or maintenance of apical/basal cell polarity#GO:0035088;trans-synaptic signaling#GO:0099537;system development#GO:0048731;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cell communication#GO:0007154;localization#GO:0051179;anatomical structure development#GO:0048856;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;synaptic membrane#GO:0097060;cell junction#GO:0030054;neuromuscular junction#GO:0031594;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density membrane#GO:0098839 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG104567|UniProtKB=T1EDM4 T1EDM4 20194676 PTHR12962:SF1 CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;regulation of mRNA stability#GO:0043488;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178807|UniProtKB=T1FDR6 T1FDR6 20206965 PTHR24351:SF209 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 response to oxygen-containing compound#GO:1901700;response to endogenous stimulus#GO:0009719;response to hormone#GO:0009725;response to nitrogen compound#GO:1901698;response to peptide hormone#GO:0043434;response to stimulus#GO:0050896;response to chemical#GO:0042221 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164453|UniProtKB=T1EVF5 T1EVF5 20200555 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160343|UniProtKB=T1EQ43 T1EQ43 20198693 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160090|UniProtKB=T1EPR8 T1EPR8 20198568 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97098|UniProtKB=T1G9F4 T1G9F4 20217701 PTHR11586:SF43 TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER TYROSINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263 HELRO|EnsemblGenome=HelroG72627|UniProtKB=T1G128 T1G128 20214776 PTHR22906:SF58 PROPERDIN SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194830|UniProtKB=T1FWG6 T1FWG6 20213161 PTHR23504:SF1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 GH21943P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG159200|UniProtKB=T1ENQ6 T1ENQ6 20198206 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG95955|UniProtKB=T1G990 T1G990 20217637 PTHR19957:SF411 SYNTAXIN LD23667P SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization#GO:0016043;vesicle fusion#GO:0006906;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;organelle organization#GO:0006996;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050 secretory vesicle#GO:0099503;membrane#GO:0016020;presynapse#GO:0098793;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;transport vesicle#GO:0030133;cytoplasm#GO:0005737;cell junction#GO:0030054;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synapse#GO:0045202;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 SNARE protein#PC00034 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HELRO|EnsemblGenome=HelroG160196|UniProtKB=T1EPY3 T1EPY3 20198633 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR ALLATOSTATIN A RECEPTOR 2, ISOFORM A G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG178878|UniProtKB=T1FDU6 T1FDU6 20206995 PTHR37002:SF10 AGAP007005-PA F-BOX_LRR-REPEAT PROTEIN 15-LIKE LEUCIN RICH REPEAT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70514|UniProtKB=T1G075 T1G075 20214473 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189943|UniProtKB=T1FRI5 T1FRI5 20211432 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG78899|UniProtKB=T1G3H1 T1G3H1 20215619 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491 cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to chemical#GO:0042221;response to stimulus#GO:0050896;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG171762|UniProtKB=T1F4M2 T1F4M2 20203771 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169290|UniProtKB=T1F1Q8 T1F1Q8 20202758 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185899|UniProtKB=T1FNE9 T1FNE9 20210346 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG74285|UniProtKB=T1G1P3 T1G1P3 20214991 PTHR23431:SF3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;zinc ion binding#GO:0008270;cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974 DNA metabolism protein#PC00009 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG159876|UniProtKB=T1EPH4 T1EPH4 20198474 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG191137|UniProtKB=T1FSM8 T1FSM8 20211825 PTHR18921:SF2 MYOSIN HEAVY CHAIN - RELATED THYROID RECEPTOR-INTERACTING PROTEIN 11 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular localization#GO:0051641;establishment of localization#GO:0051234;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG65967|UniProtKB=T1FYF4 T1FYF4 20213852 PTHR42790:SF24 AMINOTRANSFERASE KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 transaminase#PC00216 HELRO|EnsemblGenome=HelroG176148|UniProtKB=T1FA75 T1FA75 20205724 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172137|UniProtKB=T1F522 T1F522 20203921 PTHR14167:SF132 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG71201|UniProtKB=T1G0H7 T1G0H7 20214575 PTHR20935:SF0 PHOSPHOGLYCERATE MUTASE-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 positive regulation of cellular component organization#GO:0051130;positive regulation of developmental process#GO:0051094;positive regulation of organelle organization#GO:0010638;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;regulation of mitochondrial fission#GO:0090140;biological regulation#GO:0065007;positive regulation of mitochondrial fission#GO:0090141;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mutase#PC00160;isomerase#PC00135 HELRO|EnsemblGenome=HelroG72070|UniProtKB=T1G0U9 T1G0U9 20214697 PTHR45738:SF5 POLYPHOSPHOINOSITIDE PHOSPHATASE POLYPHOSPHOINOSITIDE PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;dephosphorylation#GO:0016311;lipid modification#GO:0030258 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG171586|UniProtKB=T1F4F5 T1F4F5 20203704 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG159663|UniProtKB=T1EPA4 T1EPA4 20198404 PTHR37474:SF1 RNA LIGASE/CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2'-5' RNA LIGASE FAMILY PROTEIN HELRO|EnsemblGenome=HelroG133157|UniProtKB=T1EI03 T1EI03 20196203 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG115530|UniProtKB=T1EG90 T1EG90 20195592 PTHR11252:SF0 POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;mitochondrial RNA processing#GO:0000963;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;gene expression#GO:0010467;mitochondrial RNA 3'-end processing#GO:0000965;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA 3'-end processing#GO:0031123 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG190525|UniProtKB=T1FS25 T1FS25 20211622 PTHR46275:SF1 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;endocytosis#GO:0006897;endocytic recycling#GO:0032456;receptor-mediated endocytosis#GO:0006898;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;receptor internalization#GO:0031623 intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769 HELRO|EnsemblGenome=HelroG163344|UniProtKB=T1ETX8 T1ETX8 20200028 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG176143|UniProtKB=T1FA71 T1FA71 20205720 PTHR33244:SF8 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71642|UniProtKB=T1G0P6 T1G0P6 20214644 PTHR28661:SF2 SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1 SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1 HOMOLOG membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG171773|UniProtKB=T1F4N1 T1F4N1 20203780 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144803|UniProtKB=T1EJG5 T1EJG5 20196715 PTHR24171:SF15 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50-RELATED HELRO|EnsemblGenome=HelroG91677|UniProtKB=T1G876 T1G876 20217273 PTHR16797:SF4 FACTOR VIII-ASSOCIATED GENE 1 40-KDA HUNTINGTIN-ASSOCIATED PROTEIN vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of organelle localization#GO:0051656;establishment of vesicle localization#GO:0051650;intracellular transport#GO:0046907;organelle localization#GO:0051640;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;vesicle cytoskeletal trafficking#GO:0099518 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG165525|UniProtKB=T1EWY9 T1EWY9 20201089 PTHR13464:SF0 TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP SAP30-BINDING PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG184650|UniProtKB=T1FLP0 T1FLP0 20209739 PTHR47160:SF13 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161804|UniProtKB=T1ERX6 T1ERX6 20199326 PTHR12439:SF11 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE HELRO|EnsemblGenome=HelroG184933|UniProtKB=T1FM65 T1FM65 20209914 PTHR12027:SF112 WNT RELATED PROTEIN WNT-2 cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;Wnt signaling pathway#GO:0016055;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;nervous system development#GO:0007399;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;multicellular organism development#GO:0007275;regulation of JNK cascade#GO:0046328;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cell fate commitment#GO:0045165;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HELRO|EnsemblGenome=HelroG163285|UniProtKB=T1ETV4 T1ETV4 20200004 PTHR13382:SF67 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B F-BOX AND LEUCINE RICH REPEAT PROTEIN 20 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG116813|UniProtKB=T1EGI1 T1EGI1 20195683 PTHR10545:SF29 DIAMINE N-ACETYLTRANSFERASE GH14572P-RELATED acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 transferase#PC00220;acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG175368|UniProtKB=T1F971 T1F971 20205370 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG90782|UniProtKB=T1G7W2 T1G7W2 20217159 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG161478|UniProtKB=T1ERI6 T1ERI6 20199186 PTHR23122:SF14 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PROTEIN PALS1 animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of bipolar cell polarity#GO:0061245;generation of neurons#GO:0048699;localization within membrane#GO:0051668;cellular localization#GO:0051641;anatomical structure development#GO:0048856;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;tissue morphogenesis#GO:0048729;system development#GO:0048731;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;protein localization to cell periphery#GO:1990778;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;morphogenesis of an epithelium#GO:0002009;neurogenesis#GO:0022008;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelium development#GO:0060429;embryo development#GO:0009790;nervous system development#GO:0007399 adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175938|UniProtKB=T1F9X8 T1F9X8 20205627 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG178558|UniProtKB=T1FDD6 T1FDD6 20206835 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG67947|UniProtKB=T1FZ82 T1FZ82 20214130 PTHR24351:SF228 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191040|UniProtKB=T1FSJ1 T1FSJ1 20211788 PTHR12431:SF19 SORTING NEXIN 17 AND 27 SORTING NEXIN-27 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule metabolic process#GO:0043170;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;metabolic process#GO:0008152;intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175453|UniProtKB=T1F997 T1F997 20205396 PTHR43437:SF3 HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG170023|UniProtKB=T1F2J8 T1F2J8 20203048 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG188796|UniProtKB=T1FQD3 T1FQD3 20211030 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG109994|UniProtKB=T1EEY1 T1EEY1 20195133 PTHR12295:SF35 FURRY-RELATED PROTEIN FURRY neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175 cell division site#GO:0032153;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161712|UniProtKB=T1ERT7 T1ERT7 20199287 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG104950|UniProtKB=T1EDP3 T1EDP3 20194695 PTHR21646:SF14 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITINYL HYDROLASE 1 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG185736|UniProtKB=T1FN79 T1FN79 20210277 PTHR12930:SF0 ZINC FINGER PROTEIN 183 RING FINGER PROTEIN 113A1 ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG193739|UniProtKB=T1FVB0 T1FVB0 20212756 PTHR13455:SF7 TRANSCRIPTIONAL REPRESSOR P66-RELATED SIMJANG, ISOFORM E DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG84014|UniProtKB=T1G5D3 T1G5D3 20216280 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG80670|UniProtKB=T1G437 T1G437 20215835 PTHR15036:SF88 PIKACHURIN-LIKE PROTEIN PIKACHURIN cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731 cell junction#GO:0030054;extracellular region#GO:0005576;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;basement membrane#GO:0005604;extracellular matrix#GO:0031012;membrane#GO:0016020;external encapsulating structure#GO:0030312 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG173738|UniProtKB=T1F765 T1F765 20204664 PTHR21531:SF0 LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED PROTEIN LTV1 HOMOLOG establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;ribosomal small subunit biogenesis#GO:0042274;transport#GO:0006810;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;ribonucleoprotein complex biogenesis#GO:0022613;establishment of organelle localization#GO:0051656;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;ribosome biogenesis#GO:0042254;organelle localization#GO:0051640 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG72567|UniProtKB=T1G119 T1G119 20214767 PTHR13806:SF47 FLOTILLIN-RELATED FLOTILLIN-1 biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;positive regulation of endocytosis#GO:0045807;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;regulation of vesicle-mediated transport#GO:0060627;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of endocytosis#GO:0030100;positive regulation of cellular component organization#GO:0051130 plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;caveola#GO:0005901;cell periphery#GO:0071944;membrane microdomain#GO:0098857;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane raft#GO:0045121;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;plasma membrane raft#GO:0044853;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG75388|UniProtKB=T1G245 T1G245 20215143 PTHR11532:SF73 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE D carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;proteolysis#GO:0006508;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190 HELRO|EnsemblGenome=HelroG176727|UniProtKB=T1FAU4 T1FAU4 20205943 PTHR15741:SF27 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR AP-4 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG96898|UniProtKB=T1G9E3 T1G9E3 20217690 PTHR17149:SF4 NUCLEAR PROTEIN 1 AND 2 RH17958P negative regulation of cellular process#GO:0048523;negative regulation of cell cycle#GO:0045786;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cell population proliferation#GO:0008285;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG69983|UniProtKB=T1G010 T1G010 20214408 PTHR45134:SF5 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155930|UniProtKB=T1ELP3 T1ELP3 20197493 PTHR24078:SF586 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 5 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG116562|UniProtKB=T1EGG1 T1EGG1 20195663 PTHR43407:SF1 GLUTAMINE SYNTHETASE LENGSIN ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;proteinogenic amino acid biosynthetic process#GO:0170038;chemical homeostasis#GO:0048878;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;response to nutrient levels#GO:0031667;oxoacid metabolic process#GO:0043436;homeostatic process#GO:0042592;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483 HELRO|EnsemblGenome=HelroG185816|UniProtKB=T1FNB9 T1FNB9 20210316 PTHR45688:SF3 FAMILY NOT NAMED ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG164221|UniProtKB=T1EV42 T1EV42 20200442 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182633|UniProtKB=T1FII5 T1FII5 20208634 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62501|UniProtKB=T1FX16 T1FX16 20213364 PTHR10217:SF642 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transport#GO:0006810 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG127015|UniProtKB=T1EHC1 T1EHC1 20195971 PTHR10252:SF163 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 DNA-templated transcription#GO:0006351;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG184835|UniProtKB=T1FM24 T1FM24 20209873 PTHR19877:SF13 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;spliceosomal snRNP assembly#GO:0000387;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 SMN complex#GO:0032797;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114 translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG185984|UniProtKB=T1FNI7 T1FNI7 20210384 PTHR11618:SF85 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB binding#GO:0005488;transcription factor binding#GO:0008134;protein binding#GO:0005515 transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;nucleus#GO:0005634 general transcription factor#PC00259 General transcription regulation#P00023>TFIIB#P00668;Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397 HELRO|EnsemblGenome=HelroG189361|UniProtKB=T1FR01 T1FR01 20211248 PTHR21502:SF4 ZINC FINGER PROTEIN DZIP1 RILP-LIKE PROTEIN HOMOLOG enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;small GTPase binding#GO:0031267 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;cilium#GO:0005929;intracellular organelle#GO:0043229 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG186029|UniProtKB=T1FNK2 T1FNK2 20210399 PTHR23003:SF62 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG72757|UniProtKB=T1G151 T1G151 20214799 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;potassium ion transport#GO:0006813;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191057|UniProtKB=T1FSJ7 T1FSJ7 20211794 PTHR31061:SF38 LD22376P HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE, ISOFORM A acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;glycoprotein metabolic process#GO:0009100;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG187742|UniProtKB=T1G8J7 T1G8J7 20217394 PTHR10484:SF162 HISTONE H4 HISTONE H4-LIKE PROTEIN TYPE G structural molecule activity#GO:0005198 protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG85571|UniProtKB=T1G5Z8 T1G5Z8 20216495 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG112421|UniProtKB=T1EFJ7 T1EFJ7 20195349 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG105479|UniProtKB=T1EDV4 T1EDV4 20194756 PTHR12714:SF9 PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;O-methyltransferase activity#GO:0008171;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193651|UniProtKB=T1FV81 T1FV81 20212727 PTHR21219:SF3 FI19613P1 FI19613P1 HELRO|EnsemblGenome=HelroG66900|UniProtKB=T1FYS7 T1FYS7 20213975 PTHR12566:SF9 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1 ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;translation factor activity#GO:0180051 negative regulation of translation#GO:0017148;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of translation#GO:0006417;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 neuron projection#GO:0043005;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG186668|UniProtKB=T1FP21 T1FP21 20210568 PTHR23504:SF126 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 BCDNA.LD28419 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG170222|UniProtKB=T1F2T0 T1F2T0 20203129 PTHR46664:SF1 ATM INTERACTOR ATM INTERACTOR sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG167028|UniProtKB=T1EYX2 T1EYX2 20201772 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;DNA exonuclease activity#GO:0004529;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;DNA endonuclease activity#GO:0004520;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895 DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 HELRO|EnsemblGenome=HelroG188638|UniProtKB=T1FQ74 T1FQ74 20210971 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG131728|UniProtKB=T1EHW5 T1EHW5 20196165 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG74671|UniProtKB=T1G1T8 T1G1T8 20215036 PTHR12822:SF2 PROTEIN YIPF PROTEIN YIPF Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG193633|UniProtKB=T1FV77 T1FV77 20212723 PTHR44303:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 cellular component organization or biogenesis#GO:0071840;regulation of biological quality#GO:0065008;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;regulation of anatomical structure size#GO:0090066;metabolic process#GO:0008152;catabolic process#GO:0009056;macroautophagy#GO:0016236;biological regulation#GO:0065007;cellular component organization#GO:0016043;organelle organization#GO:0006996;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;regulation of cellular component size#GO:0032535 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 chaperone#PC00072 HELRO|EnsemblGenome=HelroG106063|UniProtKB=T1EDZ9 T1EDZ9 20194801 PTHR22599:SF11 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR-LIKE 3 kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG165799|UniProtKB=T1EXA8 T1EXA8 20201208 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN SHIFTED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG114744|UniProtKB=T1EG44 T1EG44 20195546 PTHR45622:SF76 UBIQUITIN-PROTEIN LIGASE E3A-RELATED HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG162477|UniProtKB=T1ESQ2 T1ESQ2 20199602 PTHR32001:SF1 KERATINOCYTE-ASSOCIATED PROTEIN 2 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT KCP2 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG108821|UniProtKB=T1EEM8 T1EEM8 20195030 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 transferase#PC00220 HELRO|EnsemblGenome=HelroG102897|UniProtKB=T1EDC9 T1EDC9 20194581 PTHR24210:SF0 LIM DOMAIN-CONTAINING PROTEIN LIM DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cell junction organization#GO:0034330;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signaling#GO:0023051;cell adhesion#GO:0007155;positive regulation of signaling#GO:0023056 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cell junction protein#PC00070 Integrin signalling pathway#P00034>PINCH#P00921 HELRO|EnsemblGenome=HelroG120372|UniProtKB=T1EGP8 T1EGP8 20195748 PTHR23082:SF0 TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3 transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular organelle#GO:0043229;transcription factor TFIIIC complex#GO:0000127;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG158877|UniProtKB=T1ENC9 T1ENC9 20198079 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG106099|UniProtKB=T1EE01 T1EE01 20194803 PTHR13353:SF5 TRANSMEMBRANE PROTEIN 19 TRANSMEMBRANE PROTEIN 19 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG168385|UniProtKB=T1F0I7 T1F0I7 20202337 PTHR24412:SF35 KELCH PROTEIN ACTIN-BINDING PROTEIN IPP protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171218|UniProtKB=T1F3Y5 T1F3Y5 20203534 PTHR10339:SF32 ADP-RIBOSYLTRANSFERASE ECTO-ADP-RIBOSYLTRANSFERASE 5-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757 transferase#PC00220 HELRO|EnsemblGenome=HelroG167309|UniProtKB=T1EZ88 T1EZ88 20201888 PTHR11337:SF8 MUCIN/PORIMIN VISGUN, ISOFORM E intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG179428|UniProtKB=T1FEP3 T1FEP3 20207292 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG161865|UniProtKB=T1ERZ2 T1ERZ2 20199342 PTHR15730:SF8 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED TRPM8 CHANNEL-ASSOCIATED FACTOR HOMOLOG-RELATED protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of establishment of protein localization#GO:0070201;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG156379|UniProtKB=T1ELU8 T1ELU8 20197548 PTHR13149:SF0 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25 intracellular protein transport#GO:0006886;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein transport#GO:0015031;cellular localization#GO:0051641;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;establishment of protein localization to vacuole#GO:0072666;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein localization to organelle#GO:0033365;catabolic process#GO:0009056 vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG136695|UniProtKB=T1EIF3 T1EIF3 20196353 PTHR11644:SF2 CYTIDINE DEAMINASE CYTIDINE DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 nucleoside catabolic process#GO:0009164;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;nucleoside metabolic process#GO:0009116;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 deaminase#PC00088 Pyrimidine Metabolism#P02771>Cytidine Deaminase#P03130;Salvage pyrimidine ribonucleotides#P02775>Cytidine deaminase#P03154;Salvage pyrimidine deoxyribonucleotides#P02774>Cytidine deaminase#P03144 HELRO|EnsemblGenome=HelroG182712|UniProtKB=T1FIM6 T1FIM6 20208675 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;regulation of DNA metabolic process#GO:0051052;phosphorus metabolic process#GO:0006793;regulation of cellular response to stress#GO:0080135;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleotide-sugar metabolic process#GO:0009225;regulation of nucleobase-containing compound metabolic process#GO:0019219;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of response to stress#GO:0080134 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG115469|UniProtKB=T1EG84 T1EG84 20195586 PTHR43128:SF34 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;energy derivation by oxidation of organic compounds#GO:0015980;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG94426|UniProtKB=T1G912 T1G912 20217559 PTHR15592:SF14 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG158705|UniProtKB=T1EN53 T1EN53 20198003 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG163386|UniProtKB=T1ETZ6 T1ETZ6 20200046 PTHR31802:SF54 32 KDA HEAT SHOCK PROTEIN-RELATED MARTIK, ISOFORM A-RELATED nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG114382|UniProtKB=T1EG12 T1EG12 20195514 PTHR10627:SF31 SCP160 DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176424|UniProtKB=T1FAH8 T1FAH8 20205827 PTHR13479:SF66 30S RIBOSOMAL PROTEIN S18 LARGE RIBOSOMAL SUBUNIT PROTEIN ML66 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG193676|UniProtKB=T1FV90 T1FV90 20212736 PTHR12413:SF2 DOLICHYL GLYCOSYLTRANSFERASE DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG111211|UniProtKB=T1EF96 T1EF96 20195248 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK-1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94839|UniProtKB=T1G934 T1G934 20217581 PTHR10336:SF80 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN C2 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 metabolic process#GO:0008152;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;monoatomic cation transmembrane transport#GO:0098655;glycerophospholipid metabolic process#GO:0006650;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;transport#GO:0006810;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;establishment of localization#GO:0051234;organophosphate metabolic process#GO:0019637;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794 lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193693|UniProtKB=T1FV96 T1FV96 20212742 PTHR13903:SF36 PIRIN-RELATED PIRIN transcription regulator activity#GO:0140110;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG166102|UniProtKB=T1EXR7 T1EXR7 20201367 PTHR43128:SF34 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 generation of precursor metabolites and energy#GO:0006091;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;energy derivation by oxidation of organic compounds#GO:0015980;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG172609|UniProtKB=T1F5M2 T1F5M2 20204121 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193290|UniProtKB=T1FUU3 T1FUU3 20212589 PTHR11051:SF8 GLYCOSYL HYDROLASE-RELATED MIP16835P1 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG191003|UniProtKB=T1FSH6 T1FSH6 20211773 PTHR31703:SF2 UPF0669 PROTEIN C6ORF120 UPF0669 PROTEIN C6ORF120 HELRO|EnsemblGenome=HelroG80417|UniProtKB=T1G402 T1G402 20215800 PTHR17602:SF4 RIBOSOME BIOGENESIS REGULATORY PROTEIN RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG186621|UniProtKB=T1FP18 T1FP18 20210565 PTHR43389:SF4 V-TYPE PROTON ATPASE SUBUNIT B V-TYPE PROTON ATPASE SUBUNIT B regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;proton transmembrane transport#GO:1902600;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007 transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting two-sector ATPase complex#GO:0016469;protein-containing complex#GO:0032991;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG109524|UniProtKB=T1EEU4 T1EEU4 20195096 PTHR10663:SF342 GUANYL-NUCLEOTIDE EXCHANGE FACTOR FI21420P1 regulation of endocytosis#GO:0030100;regulation of biological quality#GO:0065008;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;biological regulation#GO:0065007 postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;cell junction#GO:0030054;synaptic membrane#GO:0097060;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG173440|UniProtKB=T1F6T9 T1F6T9 20204538 PTHR13619:SF0 PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740 organophosphate biosynthetic process#GO:0090407;phosphatidylglycerol biosynthetic process#GO:0006655;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phosphatidylglycerol metabolic process#GO:0046471;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG77462|UniProtKB=T1G2Y1 T1G2Y1 20215429 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190570|UniProtKB=T1FS37 T1FS37 20211634 PTHR13598:SF1 AT07567P-RELATED AT07567P-RELATED organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG126756|UniProtKB=T1EHA9 T1EHA9 20195959 PTHR23349:SF63 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FER3-LIKE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG186235|UniProtKB=T1FNU8 T1FNU8 20210495 PTHR12697:SF42 PBS LYASE HEAT-LIKE PROTEIN DEOXYHYPUSINE HYDROXYLASE oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 lyase#PC00144 HELRO|EnsemblGenome=HelroG115802|UniProtKB=T1EGA7 T1EGA7 20195609 PTHR10603:SF7 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;regulation of cellular process#GO:0050794;RNA localization#GO:0006403;mRNA transport#GO:0051028;modulation of chemical synaptic transmission#GO:0050804;regulation of developmental process#GO:0050793;establishment of RNA localization#GO:0051236;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;regulation of neurogenesis#GO:0050767;positive regulation of biosynthetic process#GO:0009891;localization#GO:0051179;nucleic acid transport#GO:0050657;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;positive regulation of translation#GO:0045727;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of neuronal synaptic plasticity#GO:0048168;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of synaptic plasticity#GO:0048167;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;transport#GO:0006810;positive regulation of nervous system development#GO:0051962;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;positive regulation of macromolecule metabolic process#GO:0010604;regulation of trans-synaptic signaling#GO:0099177;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;animal organ development#GO:0048513;positive regulation of cell differentiation#GO:0045597 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;neuron projection#GO:0043005;nucleus#GO:0005634;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG68867|UniProtKB=T1FZK6 T1FZK6 20214254 PTHR45080:SF8 CONTACTIN 5 NEURAL CELL ADHESION MOLECULE 1 ISOFORM X1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell adhesion#GO:0007155;cell junction organization#GO:0034330;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;homophilic cell-cell adhesion#GO:0007156;cellular process#GO:0009987 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;cell body#GO:0044297;membrane#GO:0016020;axon#GO:0030424 HELRO|EnsemblGenome=HelroG179010|UniProtKB=T1FE19 T1FE19 20207068 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178672|UniProtKB=T1FDJ7 T1FDJ7 20206896 PTHR10270:SF161 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG169306|UniProtKB=T1F1R6 T1F1R6 20202766 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185509|UniProtKB=T1FMW8 T1FMW8 20210167 PTHR45636:SF49 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED SEGMENTATION PROTEIN PAIRED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG85985|UniProtKB=T1G656 T1G656 20216553 PTHR32385:SF15 MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;carbohydrate derivative biosynthetic process#GO:1901137;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;glycosphingolipid biosynthetic process#GO:0006688;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;liposaccharide metabolic process#GO:1903509;phospholipid metabolic process#GO:0006644 transferase#PC00220;metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG190472|UniProtKB=T1FS05 T1FS05 20211602 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG78915|UniProtKB=T1G3H3 T1G3H3 20215621 PTHR12086:SF11 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2 cellular component organization or biogenesis#GO:0071840;regulation of plasma membrane bounded cell projection organization#GO:0120035;multicellular organism development#GO:0007275;developmental growth#GO:0048589;regulation of anatomical structure morphogenesis#GO:0022603;neuromuscular junction development#GO:0007528;regulation of cell projection organization#GO:0031344;developmental process#GO:0032502;growth#GO:0040007;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;regulation of cellular component organization#GO:0051128;regulation of dendrite development#GO:0050773;synapse assembly#GO:0007416;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of dendrite morphogenesis#GO:0048814;regulation of biological process#GO:0050789 cytoplasmic microtubule#GO:0005881;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG156827|UniProtKB=T1EM16 T1EM16 20197616 PTHR11758:SF16 40S RIBOSOMAL PROTEIN S15A SMALL RIBOSOMAL SUBUNIT PROTEIN US8 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185132|UniProtKB=T1FMF7 T1FMF7 20210006 PTHR10404:SF84 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;peptidase activity#GO:0008233;catalytic activity#GO:0003824 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG166955|UniProtKB=T1EYT1 T1EYT1 20201731 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG156421|UniProtKB=T1ELW0 T1ELW0 20197560 PTHR12209:SF0 NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE EKC_KEOPS COMPLEX SUBUNIT TP53RK catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG188601|UniProtKB=T1FQ60 T1FQ60 20210957 PTHR11884:SF2 SELECTIN LIGAND RELATED GOLGI COMPLEX-LOCALIZED GLYCOPROTEIN 1, ISOFORM B membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG188091|UniProtKB=T1FPM2 T1FPM2 20210769 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;reproductive process#GO:0022414;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;motile cilium#GO:0031514;organelle#GO:0043226;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG174267|UniProtKB=T1F7W8 T1F7W8 20204917 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG67914|UniProtKB=T1FZ76 T1FZ76 20214124 PTHR12968:SF2 B9 DOMAIN-CONTAINING B9 DOMAIN-CONTAINING PROTEIN 2 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 membrane-bounded organelle#GO:0043227;cilium#GO:0005929;ciliary transition zone#GO:0035869;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 structural protein#PC00211 HELRO|EnsemblGenome=HelroG177712|UniProtKB=T1FC44 T1FC44 20206393 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172705|UniProtKB=T1F5T8 T1F5T8 20204187 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185061|UniProtKB=T1FMC3 T1FMC3 20209972 PTHR12710:SF0 NUCLEAR PROTEIN LOCALIZATION 4 NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG186077|UniProtKB=T1FNM9 T1FNM9 20210426 PTHR11711:SF479 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 1 nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf1#P00923 HELRO|EnsemblGenome=HelroG177648|UniProtKB=T1FC04 T1FC04 20206353 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181271|UniProtKB=T1FGT8 T1FGT8 20208037 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG183244|UniProtKB=T1FJD0 T1FJD0 20208929 PTHR48192:SF1 ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG) HELRO|EnsemblGenome=HelroG155589|UniProtKB=T1ELJ3 T1ELJ3 20197443 PTHR23118:SF42 ATP-CITRATE SYNTHASE ATP-CITRATE SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 acetyl-CoA metabolic process#GO:0006084;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;purine-containing compound metabolic process#GO:0072521;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;monocarboxylic acid biosynthetic process#GO:0072330;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;lipid biosynthetic process#GO:0008610 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 transferase#PC00220 Pyruvate metabolism#P02772>Citrate Lyase#P03137 HELRO|EnsemblGenome=HelroG189732|UniProtKB=T1FRB2 T1FRB2 20211359 PTHR23003:SF71 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;nuclear mRNA surveillance#GO:0071028;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG159697|UniProtKB=T1EPB6 T1EPB6 20198416 PTHR42650:SF1 TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum protein-containing complex#GO:0140534 HELRO|EnsemblGenome=HelroG184303|UniProtKB=T1FKY0 T1FKY0 20209479 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176384|UniProtKB=T1FAG8 T1FAG8 20205817 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165227|UniProtKB=T1EWG6 T1EWG6 20200916 PTHR47980:SF23 LD44762P SMALL MONOMERIC GTPASE localization within membrane#GO:0051668;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;secretion by cell#GO:0032940;endocytic recycling#GO:0032456;export from cell#GO:0140352;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;endosomal transport#GO:0016197;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;endomembrane system#GO:0012505;secretory vesicle#GO:0099503;membrane#GO:0016020;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794 TGF-beta signaling pathway#P00052>Ras-GTP#P01280;TGF-beta signaling pathway#P00052>Ras-GDP#P01291 HELRO|EnsemblGenome=HelroG164644|UniProtKB=T1EVN9 T1EVN9 20200639 PTHR22761:SF10 CHARGED MULTIVESICULAR BODY PROTEIN BCDNA.GH08385-RELATED vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;nuclear envelope organization#GO:0006998;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;nucleus organization#GO:0006997;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;nuclear membrane organization#GO:0071763;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;localization#GO:0051179;cellular localization#GO:0051641;membrane assembly#GO:0071709;cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324 cytoplasmic side of membrane#GO:0098562;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;vesicle#GO:0031982;cytoplasmic side of plasma membrane#GO:0009898;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68834|UniProtKB=T1FZK3 T1FZK3 20214251 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183130|UniProtKB=T1FJ62 T1FJ62 20208861 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG161938|UniProtKB=T1ES20 T1ES20 20199370 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG168802|UniProtKB=T1F0Z8 T1F0Z8 20202498 PTHR13802:SF52 MUCIN 4-RELATED NIDOGEN-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG175740|UniProtKB=T1F9M0 T1F9M0 20205519 PTHR24073:SF315 DRAB5-RELATED RAS-RELATED PROTEIN RAB-29 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein transport#GO:0015031 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG193752|UniProtKB=T1FVB5 T1FVB5 20212761 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG158537|UniProtKB=T1EMX7 T1EMX7 20197927 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG127547|UniProtKB=T1EHF3 T1EHF3 20196001 PTHR15710:SF214 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG190074|UniProtKB=T1FRN5 T1FRN5 20211482 PTHR16184:SF6 ELONGATOR COMPLEX PROTEIN 6 ELONGATOR COMPLEX PROTEIN 6 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;elongator holoenzyme complex#GO:0033588;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG191945|UniProtKB=T1FTF8 T1FTF8 20212105 PTHR11091:SF0 OXIDOREDUCTASE-RELATED MALATE DEHYDROGENASE metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Allantoin degradation#P02725>Ureidoglycolate dehydrogenase#P02820;TCA cycle#P00051>Malate Dehydrogenase#P01270;Pyruvate metabolism#P02772>Malate Dehydrogenase#P03138 HELRO|EnsemblGenome=HelroG162678|UniProtKB=T1ET04 T1ET04 20199704 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184296|UniProtKB=T1FKX7 T1FKX7 20209476 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG167438|UniProtKB=T1EZD6 T1EZD6 20201936 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG86309|UniProtKB=T1G6A2 T1G6A2 20216599 PTHR47227:SF5 DNA-DIRECTED RNA POLYMERASE SUBUNIT K DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;RNA polymerase I complex#GO:0005736;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665 DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG186153|UniProtKB=T1FNQ7 T1FNQ7 20210454 PTHR11353:SF22 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ETA protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG174641|UniProtKB=T1F8C1 T1F8C1 20205070 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG105874|UniProtKB=T1EDY1 T1EDY1 20194783 PTHR31488:SF1 DPY-19-LIKE 1, LIKE (H. SAPIENS) DPY-19 LIKE C-MANNOSYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG63304|UniProtKB=T1FXD9 T1FXD9 20213487 PTHR45720:SF10 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254 transport#GO:0006810;chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189194|UniProtKB=T1FQR8 T1FQR8 20211165 PTHR45766:SF3 DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697 macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185016|UniProtKB=T1FMA1 T1FMA1 20209950 PTHR12439:SF11 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE HELRO|EnsemblGenome=HelroG186188|UniProtKB=T1FNS4 T1FNS4 20210471 PTHR13609:SF4 UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED RE42193P ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG164888|UniProtKB=T1EVX2 T1EVX2 20200722 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108746|UniProtKB=T1EEM2 T1EEM2 20195024 PTHR11071:SF585 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 6-RELATED chaperone#PC00072 HELRO|EnsemblGenome=HelroG185934|UniProtKB=T1FNG4 T1FNG4 20210361 PTHR13074:SF9 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG169281|UniProtKB=T1F1Q0 T1F1Q0 20202750 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177663|UniProtKB=T1FC12 T1FC12 20206361 PTHR45930:SF4 G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN REMOULADE cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG170946|UniProtKB=T1F3M1 T1F3M1 20203420 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG165872|UniProtKB=T1EXD8 T1EXD8 20201238 PTHR23059:SF4 CYSTEINE AND HISTIDINE-RICH PROTEIN 1 ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG159947|UniProtKB=T1EPL2 T1EPL2 20198512 PTHR12232:SF15 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG174206|UniProtKB=T1F7S5 T1F7S5 20204874 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62459|UniProtKB=T1FX10 T1FX10 20213358 PTHR43053:SF4 GLYCOSIDASE FAMILY 31 RE74917P metabolite interconversion enzyme#PC00262;hydrolase#PC00121;glucosidase#PC00108 HELRO|EnsemblGenome=HelroG181447|UniProtKB=T1FH06 T1FH06 20208105 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG139909|UniProtKB=T1EIZ5 T1EIZ5 20196545 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG108140|UniProtKB=T1EEF8 T1EEF8 20194960 PTHR23123:SF35 PHD/F-BOX CONTAINING PROTEIN F-BOX_LRR-REPEAT PROTEIN 19 demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;catalytic activity#GO:0003824;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;histone demethylase activity#GO:0032452;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;histone modifying activity#GO:0140993;protein-macromolecule adaptor activity#GO:0030674 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;chromatin remodeling#GO:0006338;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;chromatin organization#GO:0006325 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG173102|UniProtKB=T1F6C6 T1F6C6 20204375 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64118|UniProtKB=T1FXP8 T1FXP8 20213596 PTHR13304:SF0 GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN GPI-ANCHOR TRANSAMIDASE COMPONENT GPAA1 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;GPI anchored protein biosynthesis#GO:0180046;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endopeptidase complex#GO:1905369;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;caspase complex#GO:0008303;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796 HELRO|EnsemblGenome=HelroG174283|UniProtKB=T1F7X7 T1F7X7 20204926 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG67329|UniProtKB=T1FYZ7 T1FYZ7 20214045 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG83507|UniProtKB=T1G565 T1G565 20216213 PTHR43344:SF2 PHOSPHOSERINE PHOSPHATASE PHOSPHOSERINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;magnesium ion binding#GO:0000287;cation binding#GO:0043169;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;proteinogenic amino acid biosynthetic process#GO:0170038;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 Serine glycine biosynthesis#P02776>Phosphoserine phosphatase#P03159 HELRO|EnsemblGenome=HelroG163281|UniProtKB=T1ETV3 T1ETV3 20200003 PTHR12932:SF9 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;positive regulation of protein polymerization#GO:0032273;microtubule bundle formation#GO:0001578;positive regulation of cellular component organization#GO:0051130;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG109550|UniProtKB=T1EEU7 T1EEU7 20195099 PTHR10971:SF11 MRNA EXPORT FACTOR AND BUB3 MRNA EXPORT FACTOR RAE1 nucleic acid binding#GO:0003676;binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515;RNA binding#GO:0003723 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;cellular component organization#GO:0016043;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG86541|UniProtKB=T1G6D7 T1G6D7 20216634 PTHR16515:SF88 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG145168|UniProtKB=T1EJJ1 T1EJJ1 20196741 PTHR45880:SF1 RNA-BINDING MOTIF PROTEIN, X-LINKED 2 RNA-BINDING MOTIF PROTEIN, X-LINKED 2 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG175670|UniProtKB=T1F9I1 T1F9I1 20205480 PTHR13866:SF29 SPARC OSTEONECTIN FOLLISTATIN ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG103835|UniProtKB=T1EDH8 T1EDH8 20194630 PTHR43381:SF4 TRANSLATION INITIATION FACTOR IF-2-RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 5B translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG76232|UniProtKB=T1G2G9 T1G2G9 20215267 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG192214|UniProtKB=T1FTP8 T1FTP8 20212195 PTHR15346:SF0 DYNACTIN SUBUNIT DYNACTIN SUBUNIT 2 protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093 cytoskeleton organization#GO:0007010;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;mitotic spindle organization#GO:0007052;nuclear migration#GO:0007097;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;microtubule-based transport#GO:0099111;organelle localization#GO:0051640 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;organelle#GO:0043226 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG179951|UniProtKB=T1FFA1 T1FFA1 20207500 PTHR31394:SF1 TRANSMEMBRANE PROTEIN 199 VACUOLAR ATPASE ASSEMBLY PROTEIN VMA12 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG84020|UniProtKB=T1G5D4 T1G5D4 20216281 PTHR10075:SF53 BASIGIN RELATED CELL ADHESION MOLECULE DSCAM1 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;nervous system development#GO:0007399;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG76967|UniProtKB=T1G2R9 T1G2R9 20215367 PTHR11051:SF8 GLYCOSYL HYDROLASE-RELATED MIP16835P1 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG191013|UniProtKB=T1FSI0 T1FSI0 20211777 PTHR12673:SF159 FACIOGENITAL DYSPLASIA PROTEIN LD03170P molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG66726|UniProtKB=T1FYP4 T1FYP4 20213942 PTHR15239:SF6 NUCLEAR EXPORT MEDIATOR FACTOR NEMF RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF ribosomal large subunit binding#GO:0043023;nucleic acid binding#GO:0003676;binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;protein-containing complex binding#GO:0044877;tRNA binding#GO:0000049;ribosome binding#GO:0043022 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;rescue of stalled cytosolic ribosome#GO:0072344;modification-dependent protein catabolic process#GO:0019941;protein biosynthetic process#GO:0160307;catabolic process#GO:0009056;cytoplasmic translation#GO:0002181;translation#GO:0006412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;organelle disassembly#GO:1903008;organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;translational elongation#GO:0006414;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG161308|UniProtKB=T1ERB6 T1ERB6 20199116 PTHR15924:SF9 CLE TRNA-SPLICING LIGASE COMPLEX SUBUNIT RTRAF RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA splicing#GO:0008380;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG162896|UniProtKB=T1ETC2 T1ETC2 20199822 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG192394|UniProtKB=T1FTW5 T1FTW5 20212262 PTHR10288:SF356 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG83478|UniProtKB=T1G560 T1G560 20216208 PTHR12027:SF98 WNT RELATED PROTEIN WNT frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;system development#GO:0048731;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG188870|UniProtKB=T1FQF3 T1FQF3 20211050 PTHR34529:SF1 AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN binding#GO:0005488;protein-containing complex binding#GO:0044877 Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;Golgi to endosome transport#GO:0006895;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;transport vesicle#GO:0030133;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG192969|UniProtKB=T1FUG9 T1FUG9 20212465 PTHR24393:SF15 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG64799|UniProtKB=T1FXZ5 T1FXZ5 20213693 PTHR13071:SF4 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22 SMALL RIBOSOMAL SUBUNIT PROTEIN MS22 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG63917|UniProtKB=T1FXM5 T1FXM5 20213573 PTHR15680:SF21 RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG69578|UniProtKB=T1FZW7 T1FZW7 20214365 PTHR19848:SF10 WD40 REPEAT PROTEIN NOTCHLESS PROTEIN HOMOLOG 1 regulation of Notch signaling pathway#GO:0008593;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG141093|UniProtKB=T1EJ26 T1EJ26 20196576 PTHR24303:SF31 HEME-BINDING MONOOXYGENASE FAMILY CYTOCHROME P450 307A1-RELATED oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG160268|UniProtKB=T1EQ12 T1EQ12 20198662 PTHR15830:SF10 TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;heat shock protein binding#GO:0031072;DNA binding#GO:0003677;protein binding#GO:0005515;Hsp90 protein binding#GO:0051879;nucleic acid binding#GO:0003676;binding#GO:0005488 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG190825|UniProtKB=T1FSB8 T1FSB8 20211715 PTHR23142:SF2 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38B macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG190910|UniProtKB=T1FSE8 T1FSE8 20211745 PTHR13309:SF0 NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1 FMR1-INTERACTING PROTEIN NUFIP1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;protein-RNA complex assembly#GO:0022618;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;ribonucleoprotein complex biogenesis#GO:0022613;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG116663|UniProtKB=T1EGG9 T1EGG9 20195671 PTHR13414:SF9 HUEL-CATION TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;zinc ion transport#GO:0006829;monoatomic ion homeostasis#GO:0050801 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transporter#PC00227 HELRO|EnsemblGenome=HelroG83905|UniProtKB=T1G5B5 T1G5B5 20216262 PTHR11671:SF5 V-TYPE ATP SYNTHASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT D monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657 regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;vacuolar acidification#GO:0007035;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;homeostatic process#GO:0042592 proton-transporting two-sector ATPase complex#GO:0016469;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG116724|UniProtKB=T1EGH2 T1EGH2 20195674 PTHR46212:SF10 PEFLIN PEFLIN cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;COPII-coated vesicle budding#GO:0090114;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;protein-containing complex organization#GO:0043933;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810 HELRO|EnsemblGenome=HelroG76552|UniProtKB=T1G2L4 T1G2L4 20215312 PTHR24346:SF49 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE NIM1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;intracellular signal transduction#GO:0035556;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161701|UniProtKB=T1ERS8 T1ERS8 20199278 PTHR12684:SF2 PUTATIVE PHOSPHOTRANSFERASE TRNA 2'-PHOSPHOTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG184464|UniProtKB=T1FL92 T1FL92 20209591 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114439|UniProtKB=T1EG17 T1EG17 20195519 PTHR23359:SF242 NUCLEOTIDE KINASE GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;small molecule metabolic process#GO:0044281;nucleoside monophosphate metabolic process#GO:0009123;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG159976|UniProtKB=T1EPM1 T1EPM1 20198521 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG112884|UniProtKB=T1EFM9 T1EFM9 20195381 PTHR19134:SF570 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;multicellular organism development#GO:0007275 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157785|UniProtKB=T1EMF6 T1EMF6 20197756 PTHR24072:SF0 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOB carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208;G-protein#PC00020 Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Integrin signalling pathway#P00034>Rho#P00948;Ras Pathway#P04393>Rho#P04578;PDGF signaling pathway#P00047>Ras#P01154;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507;Angiogenesis#P00005>GTPase#P00254 HELRO|EnsemblGenome=HelroG159466|UniProtKB=T1EP24 T1EP24 20198324 PTHR21229:SF86 LUNG SEVEN TRANSMEMBRANE RECEPTOR GH17801P vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171831|UniProtKB=T1F4R4 T1F4R4 20203813 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69050|UniProtKB=T1FZN7 T1FZN7 20214285 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG143868|UniProtKB=T1EJC7 T1EJC7 20196677 PTHR46473:SF29 GH08155P LD45603P HELRO|EnsemblGenome=HelroG96714|UniProtKB=T1G9D3 T1G9D3 20217680 PTHR15228:SF24 SPERMATHECAL PHYSIOLOGY VARIANT RHO-GAP DOMAIN-CONTAINING PROTEIN enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG182148|UniProtKB=T1FHU0 T1FHU0 20208389 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176565|UniProtKB=T1FAN6 T1FAN6 20205885 PTHR13422:SF12 SIN3-HDAC COMPLEX-ASSOCIATED FACTOR SIN3-HDAC COMPLEX-ASSOCIATED FACTOR negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cell migration#GO:0030334;regulation of cell motility#GO:2000145 chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG162085|UniProtKB=T1ES85 T1ES85 20199435 PTHR19972:SF16 CALBINDIN CALBINDIN-32 metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection terminus#GO:0044306;cell projection#GO:0042995;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;axon#GO:0030424;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;cytosol#GO:0005829;presynapse#GO:0098793;neuron projection#GO:0043005;nucleus#GO:0005634;cell junction#GO:0030054;axon terminus#GO:0043679 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG123984|UniProtKB=T1EGZ8 T1EGZ8 20195848 PTHR16509:SF1 FAMILY NOT NAMED MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE cation binding#GO:0043169;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;transition metal ion binding#GO:0046914;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;small molecule binding#GO:0036094;ion binding#GO:0043167;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 HELRO|EnsemblGenome=HelroG110038|UniProtKB=T1EEY5 T1EEY5 20195137 PTHR18934:SF213 ATP-DEPENDENT RNA HELICASE 3'-5' RNA HELICASE YTHDC2 binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG135351|UniProtKB=T1EI81 T1EI81 20196281 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG187798|UniProtKB=T1FPD8 T1FPD8 20210685 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG184371|UniProtKB=T1FL28 T1FL28 20209527 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164694|UniProtKB=T1EVQ5 T1EVQ5 20200655 PTHR28489:SF2 RENTINAL DEGENERATION 3-LIKE RENTINAL DEGENERATION 3-LIKE HELRO|EnsemblGenome=HelroG181411|UniProtKB=T1FGZ2 T1FGZ2 20208091 PTHR45647:SF139 OS02G0152300 PROTEIN RING-TYPE E3 UBIQUITIN TRANSFERASE catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 HELRO|EnsemblGenome=HelroG72057|UniProtKB=T1G0U7 T1G0U7 20214695 PTHR24637:SF422 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181731|UniProtKB=T1FH96 T1FH96 20208195 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG108915|UniProtKB=T1EEN7 T1EEN7 20195039 PTHR47978:SF21 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-26 ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of secretion#GO:0051046 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG106314|UniProtKB=T1EE18 T1EE18 20194820 PTHR19297:SF192 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3-RELATED glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG165947|UniProtKB=T1EXH8 T1EXH8 20201278 PTHR12458:SF11 ORF PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20 cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;gamete generation#GO:0007276;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;anatomical structure morphogenesis#GO:0009653;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organism development#GO:0007275;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;anatomical structure formation involved in morphogenesis#GO:0048646 axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG140465|UniProtKB=T1EJ10 T1EJ10 20196560 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508;catabolic process#GO:0009056;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG113932|UniProtKB=T1EFX5 T1EFX5 20195477 PTHR43327:SF10 STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL transporter#PC00227 HELRO|EnsemblGenome=HelroG157878|UniProtKB=T1EMH1 T1EMH1 20197771 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG155552|UniProtKB=T1ELI8 T1ELI8 20197438 PTHR11787:SF8 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG181249|UniProtKB=T1FGS7 T1FGS7 20208026 PTHR34718:SF3 PHD-TYPE DOMAIN-CONTAINING PROTEIN UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161768|UniProtKB=T1ERW0 T1ERW0 20199310 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG78206|UniProtKB=T1G395 T1G395 20215543 PTHR10357:SF237 ALPHA-GLUCOSIDASE FAMILY MEMBER ALPHA-GLUCOSIDASE oligosaccharide catabolic process#GO:0009313;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate catabolic process#GO:0016052;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;amylase#PC00048 HELRO|EnsemblGenome=HelroG179603|UniProtKB=T1FEX7 T1FEX7 20207376 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80798|UniProtKB=T1G456 T1G456 20215854 PTHR24044:SF512 NOTCH LIGAND FAMILY MEMBER PROTEIN LIN-12 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Next#P01103;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120 HELRO|EnsemblGenome=HelroG185784|UniProtKB=T1FNA3 T1FNA3 20210300 PTHR11489:SF9 40S RIBOSOMAL PROTEIN SA SMALL RIBOSOMAL SUBUNIT PROTEIN US2 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;translation#GO:0006412;organelle assembly#GO:0070925;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;ribosomal small subunit assembly#GO:0000028;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG190104|UniProtKB=T1FRP4 T1FRP4 20211491 PTHR15491:SF19 FAMILY NOT NAMED U1-TYPE DOMAIN-CONTAINING PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG157115|UniProtKB=T1EM63 T1EM63 20197663 PTHR19143:SF459 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-2-LIKE cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158191|UniProtKB=T1EMK2 T1EMK2 20197802 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG68914|UniProtKB=T1FZL0 T1FZL0 20214258 PTHR13710:SF153 DNA HELICASE RECQ FAMILY MEMBER RECQ-LIKE DNA HELICASE BLM catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG156380|UniProtKB=T1ELU9 T1ELU9 20197549 PTHR10772:SF67 10 KDA HEAT SHOCK PROTEIN 10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;protein-folding chaperone binding#GO:0051087;small molecule binding#GO:0036094;binding#GO:0005488 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG64733|UniProtKB=T1FXY3 T1FXY3 20213681 PTHR23349:SF97 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BHLH DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG189998|UniProtKB=T1FRK7 T1FRK7 20211454 PTHR13600:SF33 LEUCINE CARBOXYL METHYLTRANSFERASE LEUCINE CARBOXYL METHYLTRANSFERASE 1 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 regulation of chromosome segregation#GO:0051983;regulation of response to stimulus#GO:0048583;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle process#GO:0010564;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;regulation of chromosome separation#GO:1905818;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle#GO:0051726;regulation of cell communication#GO:0010646;regulation of sister chromatid segregation#GO:0033045;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG189938|UniProtKB=T1FRI2 T1FRI2 20211429 PTHR23257:SF761 SERINE-THREONINE PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DDB_G0290621-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG94416|UniProtKB=T1G910 T1G910 20217557 PTHR13864:SF10 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG191158|UniProtKB=T1FSN8 T1FSN8 20211835 PTHR18952:SF278 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG193326|UniProtKB=T1FUW1 T1FUW1 20212607 PTHR21331:SF2 BRCA1-ASSOCIATED ATM ACTIVATOR 1 INTEGRATOR COMPLEX ASSEMBLY FACTOR BRAT1 response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG108742|UniProtKB=T1EEM0 T1EEM0 20195022 PTHR44279:SF2 HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG73990|UniProtKB=T1G1K8 T1G1K8 20214956 PTHR11247:SF82 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 DOLICHYLDIPHOSPHATASE 1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158915|UniProtKB=T1ENE3 T1ENE3 20198093 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62544|UniProtKB=T1FX21 T1FX21 20213369 PTHR12170:SF2 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG162815|UniProtKB=T1ET75 T1ET75 20199775 PTHR11850:SF59 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN TGIF1 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG193014|UniProtKB=T1FUI7 T1FUI7 20212483 PTHR11848:SF263 TGF-BETA FAMILY PROTEIN DECAPENTAPLEGIC receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 DPP signaling pathway#P06213>DPP#P06285;DPP-SCW signaling pathway#P06212>DPP full length#P06273;BMP/activin signaling pathway-drosophila#P06211>Full-length BMP orthologous ligand#P06256;BMP/activin signaling pathway-drosophila#P06211>BMP/activin orthologous ligand#P06251;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP-SCW signaling pathway#P06212>DPP#P06272;DPP signaling pathway#P06213>DPP full length#P06282 HELRO|EnsemblGenome=HelroG85645|UniProtKB=T1G610 T1G610 20216507 PTHR24299:SF67 CYTOCHROME P450 FAMILY 1 UNSPECIFIC MONOOXYGENASE hormone metabolic process#GO:0042445;response to chemical#GO:0042221;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;cellular response to xenobiotic stimulus#GO:0071466;lipid catabolic process#GO:0016042;cellular process#GO:0009987;secondary metabolic process#GO:0019748;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;response to stimulus#GO:0050896;catabolic process#GO:0009056;xenobiotic metabolic process#GO:0006805;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;cellular response to stimulus#GO:0051716;estrogen metabolic process#GO:0008210;steroid catabolic process#GO:0006706;regulation of biological quality#GO:0065008;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG170345|UniProtKB=T1F2Y3 T1F2Y3 20203182 PTHR19282:SF511 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161513|UniProtKB=T1ERK7 T1ERK7 20199207 PTHR46516:SF1 TRNA-SPECIFIC ADENOSINE DEAMINASE 1 TRNA-SPECIFIC ADENOSINE DEAMINASE 1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on RNA#GO:0140098;deaminase activity#GO:0019239;tRNA-specific adenosine deaminase activity#GO:0008251;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;adenosine deaminase activity#GO:0004000 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG74962|UniProtKB=T1G1Y6 T1G1Y6 20215084 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG190260|UniProtKB=T1FRT9 T1FRT9 20211536 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG98923|UniProtKB=T1G9Q4 T1G9Q4 20217800 PTHR12889:SF8 GAMMA-SECRETASE SUBUNIT APH-1 GAMMA-SECRETASE SUBUNIT APH-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;signal transduction#GO:0007165;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;proteolysis#GO:0006508;cell communication#GO:0007154;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052 catalytic complex#GO:1902494;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>Aph-1#P00091;Notch signaling pathway#P00045>Aph-1#P01109;Alzheimer disease-presenilin pathway#P00004>Aph-1#P00170 HELRO|EnsemblGenome=HelroG163420|UniProtKB=T1EU09 T1EU09 20200059 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166703|UniProtKB=T1EYE3 T1EYE3 20201593 PTHR23412:SF17 STEREOCILIN RELATED OTOANCORIN-LIKE ISOFORM X1 cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG164913|UniProtKB=T1EVY9 T1EVY9 20200739 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG97359|UniProtKB=T1G9G5 T1G9G5 20217712 PTHR24251:SF57 OVOCHYMASE-RELATED CUB DOMAIN-CONTAINING PROTEIN protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG81378|UniProtKB=T1G4D8 T1G4D8 20215936 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG187969|UniProtKB=T1FPI6 T1FPI6 20210733 PTHR13251:SF3 EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG112966|UniProtKB=T1EFN7 T1EFN7 20195389 PTHR12709:SF1 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190172|UniProtKB=T1FRR4 T1FRR4 20211511 PTHR22590:SF5 MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178859|UniProtKB=T1FDT9 T1FDT9 20206988 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72882|UniProtKB=T1G166 T1G166 20214814 PTHR11616:SF303 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;amino acid transport#GO:0006865;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;glycine transport#GO:0015816;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG97005|UniProtKB=T1G9E9 T1G9E9 20217696 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;DNA-templated transcription elongation#GO:0006354;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG194553|UniProtKB=T1FW69 T1FW69 20213065 PTHR10625:SF53 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE HDAC1 deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096;histone modifying activity#GO:0140993;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;deacylase activity#GO:0160215 heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013 Wnt signaling pathway#P00057>Histone deacetylase#P01472 HELRO|EnsemblGenome=HelroG183592|UniProtKB=T1FJW4 T1FJW4 20209113 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162123|UniProtKB=T1ES94 T1ES94 20199444 PTHR23246:SF13 NEW-GLUE PROTEIN GH12359P HELRO|EnsemblGenome=HelroG181758|UniProtKB=T1FHA5 T1FHA5 20208204 PTHR24256:SF470 TRYPTASE-RELATED SERINE PROTEASE 33 serine protease#PC00203 HELRO|EnsemblGenome=HelroG191106|UniProtKB=T1FSL3 T1FSL3 20211810 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG84680|UniProtKB=T1G5L9 T1G5L9 20216366 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108457|UniProtKB=T1EEJ1 T1EEJ1 20194993 PTHR24393:SF183 ZINC FINGER PROTEIN LD28458P-RELATED transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG68360|UniProtKB=T1FZD7 T1FZD7 20214185 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157839|UniProtKB=T1EMG7 T1EMG7 20197767 PTHR10666:SF173 UBIQUITIN UBIQUITIN-LIKE PROTEIN NEDD8 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of proteolysis#GO:0030162;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;nucleus#GO:0005634;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG133608|UniProtKB=T1EI16 T1EI16 20196216 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190574|UniProtKB=T1FS39 T1FS39 20211636 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER FIBROPELLIN-1-LIKE signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG167271|UniProtKB=T1EZ75 T1EZ75 20201875 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG171628|UniProtKB=T1F4H3 T1F4H3 20203722 PTHR21646:SF114 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG192809|UniProtKB=T1FUB7 T1FUB7 20212413 PTHR22917:SF6 HEMOPEXIN DOMAIN-CONTAINING PROTEIN EG:8D8.2 PROTEIN-RELATED HELRO|EnsemblGenome=HelroG172012|UniProtKB=T1F4X8 T1F4X8 20203877 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177176|UniProtKB=T1FBB7 T1FBB7 20206116 PTHR11304:SF29 EPHRIN EPHRIN binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon development#GO:0061564;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 intercellular signal molecule#PC00207;membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG187296|UniProtKB=T1FP85 T1FP85 20210632 PTHR10996:SF277 2-HYDROXYACID DEHYDROGENASE-RELATED GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG82476|UniProtKB=T1G4S7 T1G4S7 20216075 PTHR12630:SF1 N-LINKED OLIGOSACCHARIDE PROCESSING GLUCOSIDASE 2 SUBUNIT BETA-RELATED protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG168515|UniProtKB=T1F0N4 T1F0N4 20202384 PTHR12478:SF16 DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4 PROTEIN CHARYBDE-RELATED regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;apoptotic process#GO:0006915;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646 HELRO|EnsemblGenome=HelroG97732|UniProtKB=T1G9I7 T1G9I7 20217734 PTHR23147:SF22 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG169050|UniProtKB=T1F1B6 T1F1B6 20202616 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183251|UniProtKB=T1FJD5 T1FJD5 20208934 PTHR23320:SF163 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG81117|UniProtKB=T1G496 T1G496 20215894 PTHR13168:SF0 ASSOCIATE OF C-MYC AMY-1 C-MYC-BINDING PROTEIN transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 PDGF signaling pathway#P00047>c-Myc#P01172 HELRO|EnsemblGenome=HelroG181826|UniProtKB=T1FHD6 T1FHD6 20208235 PTHR15114:SF1 REPLICATION PROTEIN A3 REPLICATION PROTEIN A 14 KDA SUBUNIT DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;damaged DNA binding#GO:0003684;single-stranded DNA binding#GO:0003697 base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mismatch repair#GO:0006298;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;site of double-strand break#GO:0035861;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;replisome#GO:0030894 Cell cycle#P00013>Pre-replication Complex#P00478 HELRO|EnsemblGenome=HelroG185411|UniProtKB=T1FMS2 T1FMS2 20210121 PTHR10174:SF130 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE phosphatidylinositol bisphosphate binding#GO:1902936;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG194755|UniProtKB=T1FWD4 T1FWD4 20213129 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride transmembrane transporter activity#GO:0015108 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG84672|UniProtKB=T1G5L7 T1G5L7 20216364 PTHR11214:SF349 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,4-MANNOSYLGLYCOLIPID BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BRN UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycolipid biosynthetic process#GO:0009247;carbohydrate derivative biosynthetic process#GO:1901137;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;glycosphingolipid biosynthetic process#GO:0006688;lipid metabolic process#GO:0006629;liposaccharide metabolic process#GO:1903509;lipid biosynthetic process#GO:0008610;glycolipid metabolic process#GO:0006664;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG184981|UniProtKB=T1FM80 T1FM80 20209929 PTHR12620:SF8 U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1 nucleic acid binding#GO:0003676;pre-mRNA binding#GO:0036002;binding#GO:0005488;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG191322|UniProtKB=T1FSV8 T1FSV8 20211905 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS HOMEOTIC PROTEIN FEMALE STERILE-RELATED histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164478|UniProtKB=T1EVH3 T1EVH3 20200573 PTHR34093:SF1 CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1 CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1 channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG167350|UniProtKB=T1EZA5 T1EZA5 20201905 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN FUCOLECTIN-6-LIKE HELRO|EnsemblGenome=HelroG178825|UniProtKB=T1FDS7 T1FDS7 20206976 PTHR23034:SF3 GLUTAMATE-RICH PROTEIN 3 SERINE-RICH ADHESIN FOR PLATELETS HELRO|EnsemblGenome=HelroG95795|UniProtKB=T1G977 T1G977 20217624 PTHR12745:SF6 SUPPRESSION OF TUMORIGENICITY 7 PROTEIN ST7 HOMOLOG HELRO|EnsemblGenome=HelroG191609|UniProtKB=T1FT45 T1FT45 20211992 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG175053|UniProtKB=T1F8S5 T1F8S5 20205224 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170812|UniProtKB=T1F3G6 T1F3G6 20203365 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG193306|UniProtKB=T1FUV2 T1FUV2 20212598 PTHR16091:SF4 TTC17 PROTEIN TPR_REGION DOMAIN-CONTAINING PROTEIN actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629 HELRO|EnsemblGenome=HelroG162422|UniProtKB=T1ESM7 T1ESM7 20199577 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG156600|UniProtKB=T1ELY9 T1ELY9 20197589 PTHR24072:SF192 RHO FAMILY GTPASE CDC42 HOMOLOG protein binding#GO:0005515;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;kinase binding#GO:0019900;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;transport#GO:0006810;endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cell communication#GO:0007154;localization#GO:0051179;supramolecular fiber organization#GO:0097435;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208;G-protein#PC00020 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;Integrin signalling pathway#P00034>Cdc42#P00938;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;Ras Pathway#P04393>Cdc42#P04569;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Cdc42#P00515;p38 MAPK pathway#P05918>Cdc42#P06041;Axon guidance mediated by netrin#P00009>cdc42#P00364;FGF signaling pathway#P00021>Rac#P00645;Axon guidance mediated by Slit/Robo#P00008>Cdc42#P00349 HELRO|EnsemblGenome=HelroG137856|UniProtKB=T1EIP3 T1EIP3 20196443 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG86841|UniProtKB=T1G6I0 T1G6I0 20216677 PTHR10343:SF84 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG171793|UniProtKB=T1F4P3 T1F4P3 20203792 PTHR13815:SF7 GOLGIN-84 GOLGIN SUBFAMILY A MEMBER 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;Golgi organization#GO:0007030;cellular component organization#GO:0016043;retrograde transport, vesicle recycling within Golgi#GO:0000301;organelle organization#GO:0006996 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi stack#GO:0005795;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG161778|UniProtKB=T1ERW7 T1ERW7 20199317 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190246|UniProtKB=T1FRT3 T1FRT3 20211530 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;synaptic signaling#GO:0099536;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG75193|UniProtKB=T1G225 T1G225 20215123 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH19970P-RELATED active transmembrane transporter activity#GO:0022804;symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;sodium ion transport#GO:0006814 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG64650|UniProtKB=T1FXX5 T1FXX5 20213673 PTHR46485:SF5 LIM DOMAIN KINASE 1 DUAL-SPECIFICITY KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG76318|UniProtKB=T1G2I3 T1G2I3 20215281 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG117320|UniProtKB=T1EGM1 T1EGM1 20195721 PTHR11730:SF60 AMMONIUM TRANSPORTER RH50, ISOFORM D channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;homeostatic process#GO:0042592 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG181506|UniProtKB=T1FH26 T1FH26 20208125 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG85270|UniProtKB=T1G5U9 T1G5U9 20216446 PTHR11005:SF161 LYSOSOMAL ACID LIPASE-RELATED LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 hydrolase#PC00121;lipase#PC00143 HELRO|EnsemblGenome=HelroG175838|UniProtKB=T1F9R0 T1F9R0 20205559 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG186030|UniProtKB=T1FNK3 T1FNK3 20210400 PTHR20852:SF57 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE 2 CYTOPLASMIC ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG64141|UniProtKB=T1FXQ2 T1FXQ2 20213600 PTHR23291:SF127 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 1-LIKE metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 regulation of apoptotic process#GO:0042981;negative regulation of signal transduction#GO:0009968;regulation of neuron apoptotic process#GO:0043523;negative regulation of neuron apoptotic process#GO:0043524;response to stress#GO:0006950;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;response to unfolded protein#GO:0006986;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;endoplasmic reticulum unfolded protein response#GO:0030968;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;cellular response to topologically incorrect protein#GO:0035967;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of extrinsic apoptotic signaling pathway#GO:2001236;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG104681|UniProtKB=T1EDN0 T1EDN0 20194682 PTHR18929:SF240 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;response to stimulus#GO:0050896;protein folding#GO:0006457;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG189238|UniProtKB=T1FQU7 T1FQU7 20211194 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG194315|UniProtKB=T1FVX2 T1FVX2 20212968 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P protein refolding#GO:0042026;protein metabolic process#GO:0019538;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to heat#GO:0009408;response to stress#GO:0006950;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;protein maturation#GO:0051604;gene expression#GO:0010467 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG95214|UniProtKB=T1G951 T1G951 20217598 PTHR21538:SF23 ANILLIN/RHOTEKIN RTKN ANILLIN septin cytoskeleton organization#GO:0032185;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;actomyosin contractile ring assembly#GO:0000915;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;cytoskeleton-dependent cytokinesis#GO:0061640;cortical actin cytoskeleton organization#GO:0030866;septin ring organization#GO:0031106;cell division#GO:0051301;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cell cycle#GO:0007049;actomyosin structure organization#GO:0031032;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278 intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;membraneless organelle#GO:0043228;contractile ring#GO:0070938;cytoskeleton#GO:0005856;actomyosin contractile ring#GO:0005826;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG108893|UniProtKB=T1EEN5 T1EEN5 20195037 PTHR48092:SF30 KNIRPS-RELATED PROTEIN-RELATED ECDYSONE RECEPTOR sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG162852|UniProtKB=T1ETA0 T1ETA0 20199800 PTHR45749:SF44 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1 HELRO|EnsemblGenome=HelroG88502|UniProtKB=T1G734 T1G734 20216881 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CELL DIVISION CYCLE 50, ISOFORM A enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810;lipid transport#GO:0006869;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178527|UniProtKB=T1FDB3 T1FDB3 20206812 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG192781|UniProtKB=T1FUA1 T1FUA1 20212397 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG181956|UniProtKB=T1FHI4 T1FHI4 20208283 PTHR46927:SF4 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG77676|UniProtKB=T1G321 T1G321 20215469 PTHR12998:SF0 TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;tRNA methylation#GO:0030488;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG157218|UniProtKB=T1EM85 T1EM85 20197685 PTHR15172:SF1 GALACTOCEREBROSIDASE GALACTOCEREBROSIDASE catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;ceramide metabolic process#GO:0006672 lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323 metabolite interconversion enzyme#PC00262;galactosidase#PC00104 HELRO|EnsemblGenome=HelroG169717|UniProtKB=T1F297 T1F297 20202947 PTHR48125:SF12 LP07818P1 CONSERVED GLUTAMIC ACID RICH PROTEIN (AFU_ORTHOLOGUE AFUA_5G09010)-RELATED Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525;Huntington disease#P00029>N-Wasp#P00769 HELRO|EnsemblGenome=HelroG177751|UniProtKB=T1FC70 T1FC70 20206419 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177865|UniProtKB=T1FCD9 T1FCD9 20206488 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG189608|UniProtKB=T1FR71 T1FR71 20211318 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192189|UniProtKB=T1FTN9 T1FTN9 20212186 PTHR23189:SF137 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN SPENITO nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG93147|UniProtKB=T1G8U1 T1G8U1 20217488 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;cytoplasm#GO:0005737;sarcoplasmic reticulum membrane#GO:0033017;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG160835|UniProtKB=T1EQS9 T1EQS9 20198929 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cellular anatomical structure#GO:0110165 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG187732|UniProtKB=T1FPC3 T1FPC3 20210670 PTHR11728:SF8 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG107353|UniProtKB=T1EE99 T1EE99 20194901 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626 intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;calcium ion homeostasis#GO:0055074;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;regulation of cytosolic calcium ion concentration#GO:0051480;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG89630|UniProtKB=T1G7F3 T1G7F3 20217000 PTHR28153:SF1 PROTEIN, PUTATIVE-RELATED DUF4484 DOMAIN-CONTAINING PROTEIN intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG159432|UniProtKB=T1EP11 T1EP11 20198311 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG88960|UniProtKB=T1G777 T1G777 20216924 PTHR12612:SF9 NUCLEAR TRANSPORT FACTOR 2 NTF2-RELATED EXPORT PROTEIN 2-RELATED nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967 HELRO|EnsemblGenome=HelroG96849|UniProtKB=T1G9D8 T1G9D8 20217685 PTHR24353:SF111 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>PKG#P00567 HELRO|EnsemblGenome=HelroG116789|UniProtKB=T1EGH8 T1EGH8 20195680 PTHR10264:SF127 BAND 7 PROTEIN-RELATED BAND 7 PROTEIN CG42540 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG176454|UniProtKB=T1FAI8 T1FAI8 20205837 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG171867|UniProtKB=T1F4S5 T1F4S5 20203824 PTHR39408:SF3 MUCIN-21 TANDEM-REPEATING REGION OF MUCIN EPIGLYCANIN-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG182927|UniProtKB=T1FIX7 T1FIX7 20208776 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG163750|UniProtKB=T1EUF0 T1EUF0 20200200 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG169536|UniProtKB=T1F221 T1F221 20202871 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG71126|UniProtKB=T1G0G9 T1G0G9 20214567 PTHR24388:SF53 ZINC FINGER PROTEIN AT-RICH BINDING PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG84100|UniProtKB=T1G5E7 T1G5E7 20216294 PTHR12922:SF10 UBIQUINONE BIOSYNTHESIS PROTEIN UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG169999|UniProtKB=T1F2I6 T1F2I6 20203036 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173110|UniProtKB=T1F6D4 T1F6D4 20204383 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108080|UniProtKB=T1EEF1 T1EEF1 20194953 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83982|UniProtKB=T1G5C5 T1G5C5 20216272 PTHR12241:SF161 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874 microtubule bundle formation#GO:0001578;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG87471|UniProtKB=T1G6Q5 T1G6Q5 20216752 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 embryo development#GO:0009790;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;embryonic organ development#GO:0048568 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG186995|UniProtKB=T1FP52 T1FP52 20210599 PTHR11524:SF16 60S RIBOSOMAL PROTEIN L7 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30 binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG110719|UniProtKB=T1EF44 T1EF44 20195196 PTHR10806:SF6 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;peptidase complex#GO:1905368;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endopeptidase complex#GO:1905369;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 serine protease#PC00203 Vasopressin synthesis#P04395>Signal Peptidase#P04589;Endothelin signaling pathway#P00019>signal peptidase#P00573 HELRO|EnsemblGenome=HelroG93914|UniProtKB=T1G8Y2 T1G8Y2 20217529 PTHR32343:SF84 SERINE/ARGININE-RICH SPLICING FACTOR LD29830P RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG162893|UniProtKB=T1ETB9 T1ETB9 20199819 PTHR46114:SF2 APPLE DOMAIN-CONTAINING PROTEIN SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG189937|UniProtKB=T1FRI1 T1FRI1 20211428 PTHR45080:SF8 CONTACTIN 5 NEURAL CELL ADHESION MOLECULE 1 ISOFORM X1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell junction organization#GO:0034330;homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell adhesion#GO:0007155 axon#GO:0030424;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell body#GO:0044297;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG151216|UniProtKB=T1EKI8 T1EKI8 20197088 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG169090|UniProtKB=T1F1D7 T1F1D7 20202637 PTHR22923:SF120 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184055|UniProtKB=T1FKH9 T1FKH9 20209328 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163793|UniProtKB=T1EUH3 T1EUH3 20200223 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG64184|UniProtKB=T1FXQ9 T1FXQ9 20213607 PTHR24033:SF237 EGF-LIKE DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160702|UniProtKB=T1EQM4 T1EQM4 20198874 PTHR48138:SF2 KERATINOCYTE PROLINE-RICH PROTEIN-RELATED KERATINOCYTE PROLINE-RICH PROTEIN HELRO|EnsemblGenome=HelroG189101|UniProtKB=T1FQN3 T1FQN3 20211130 PTHR12271:SF140 POLY A POLYMERASE CID PAP -RELATED POLY(A) RNA POLYMERASE GLD2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;catalytic activity, acting on RNA#GO:0140098 negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA processing#GO:0006397;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;RNA processing#GO:0006396;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG183980|UniProtKB=T1FKE0 T1FKE0 20209289 PTHR13070:SF0 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34 nuclease activity#GO:0004518;catalytic activity, acting on a tRNA#GO:0140101;lyase activity#GO:0016829;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG113976|UniProtKB=T1EFX8 T1EFX8 20195480 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191663|UniProtKB=T1FT70 T1FT70 20212017 PTHR15131:SF3 SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1 sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;snRNA transcription by RNA polymerase II#GO:0042795;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;snRNA transcription#GO:0009301;nucleic acid biosynthetic process#GO:0141187;snRNA transcription by RNA polymerase III#GO:0042796;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG177731|UniProtKB=T1FC54 T1FC54 20206403 PTHR23309:SF58 3-HYDROXYACYL-COA DEHYROGENASE 3-HYDROXYACYL-COA DEHYDROGENASE NAD BINDING DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG174051|UniProtKB=T1F7J2 T1F7J2 20204791 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG190319|UniProtKB=T1FRW6 T1FRW6 20211563 PTHR31915:SF6 SKICH DOMAIN-CONTAINING PROTEIN SKICH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189685|UniProtKB=T1FR92 T1FR92 20211339 PTHR10825:SF75 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT POLYCOMB GROUP PROTEIN PSC chromatin binding#GO:0003682;binding#GO:0005488 negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;transferase complex#GO:1990234;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG71441|UniProtKB=T1G0L8 T1G0L8 20214616 PTHR47992:SF253 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1D phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;mitogen-activated protein kinase binding#GO:0051019;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;protein binding#GO:0005515;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway feedback loops 2#P04398>WIP-1#G04708;p53 pathway#P00059>WIP-1#G04693;p53 pathway feedback loops 2#P04398>WIP-1#P04650 HELRO|EnsemblGenome=HelroG189618|UniProtKB=T1FR76 T1FR76 20211323 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG161605|UniProtKB=T1ERP5 T1ERP5 20199245 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG165252|UniProtKB=T1EWI1 T1EWI1 20200931 PTHR21522:SF32 PROTON CHANNEL OTOP PROTON CHANNEL OTOPLC proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;proton channel activity#GO:0015252;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;proton transmembrane transport#GO:1902600;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG169296|UniProtKB=T1F1R0 T1F1R0 20202760 PTHR23419:SF8 DIVALENT CATION TOLERANCE CUTA-RELATED FI09726P cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;copper ion binding#GO:0005507;small molecule binding#GO:0036094;binding#GO:0005488 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG97655|UniProtKB=T1G9I3 T1G9I3 20217730 PTHR11932:SF76 CULLIN CULLIN-5 enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;protein binding#GO:0005515 protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG172950|UniProtKB=T1F668 T1F668 20204317 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG192654|UniProtKB=T1FU59 T1FU59 20212355 PTHR14387:SF0 THADA/DEATH RECEPTOR INTERACTING PROTEIN DUF2428 DOMAIN-CONTAINING PROTEIN enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67265|UniProtKB=T1FYZ0 T1FYZ0 20214038 PTHR21648:SF0 FLAGELLAR RADIAL SPOKE PROTEIN 3 RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 structural protein#PC00211 HELRO|EnsemblGenome=HelroG62236|UniProtKB=T1FWX5 T1FWX5 20213323 PTHR11216:SF178 EH DOMAIN AT21416P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein localization to cell periphery#GO:1990778;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;endocytic recycling#GO:0032456;endocytosis#GO:0006897 endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;early endosome#GO:0005769;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;recycling endosome#GO:0055037;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG90168|UniProtKB=T1G7L8 T1G7L8 20217065 PTHR21321:SF1 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP40 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;snRNA metabolic process#GO:0016073;rRNA processing#GO:0006364;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;snRNA processing#GO:0016180;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biological process#GO:0050789;snRNA 3'-end processing#GO:0034472;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG163117|UniProtKB=T1ETP1 T1ETP1 20199941 PTHR22738:SF10 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161503|UniProtKB=T1ERK3 T1ERK3 20199203 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG65498|UniProtKB=T1FY88 T1FY88 20213786 PTHR10858:SF30 DEOXYRIBONUCLEASE II CELL-DEATH-RELATED NUCLEASE 7 catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518 execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cell death#GO:0008219;programmed cell death#GO:0012501;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;catabolic process#GO:0009056;DNA catabolic process#GO:0006308;cellular component disassembly#GO:0022411;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG85509|UniProtKB=T1G5Y2 T1G5Y2 20216479 PTHR10290:SF3 DNA TOPOISOMERASE I DNA TOPOISOMERASE 1 DNA metabolism protein#PC00009;DNA topoisomerase#PC00017 DNA replication#P00017>DNA Topisomerase#P00536;DNA replication#P00017>Top#P00530 HELRO|EnsemblGenome=HelroG155828|UniProtKB=T1ELN0 T1ELN0 20197480 PTHR45732:SF23 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;endosomal transport#GO:0016197;microtubule-based process#GO:0007017;axo-dendritic transport#GO:0008088;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle-mediated transport#GO:0016192;lysosomal transport#GO:0007041;axonal transport#GO:0098930;microtubule-based transport#GO:0099111;localization#GO:0051179;cellular localization#GO:0051641;anterograde axonal transport#GO:0008089;microtubule-based movement#GO:0007018 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;lysosomal membrane#GO:0005765;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG163326|UniProtKB=T1ETX0 T1ETX0 20200020 PTHR16267:SF14 BANK1/PIK3AP1 FAMILY MEMBER STUMPS, ISOFORM E fibroblast growth factor receptor binding#GO:0005104;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;growth factor receptor binding#GO:0070851 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG111080|UniProtKB=T1EF78 T1EF78 20195230 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER LD05335P transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;transport#GO:0006810;zinc ion transmembrane transport#GO:0071577;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG167302|UniProtKB=T1EZ86 T1EZ86 20201886 PTHR48514:SF3 FAMILY NOT NAMED TRICHOHYALIN-PLECTIN-HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185286|UniProtKB=T1FMM0 T1FMM0 20210069 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;muscle system process#GO:0003012;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;system process#GO:0003008;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;muscle contraction#GO:0006936;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG188756|UniProtKB=T1FQC0 T1FQC0 20211017 PTHR14690:SF0 IQ MOTIF CONTAINING WITH AAA DOMAIN 1 IQ MOTIF CONTAINING WITH AAA DOMAIN 1 HELRO|EnsemblGenome=HelroG167916|UniProtKB=T1EZY4 T1EZY4 20202134 PTHR32510:SF3 TRANSMEMBRANE PROTEIN 98 TRANSMEMBRANE PROTEIN 98 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG173283|UniProtKB=T1F6M8 T1F6M8 20204477 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG180770|UniProtKB=T1FG94 T1FG94 20207843 PTHR12388:SF0 MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16 intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966 transporter#PC00227 HELRO|EnsemblGenome=HelroG177871|UniProtKB=T1FCE4 T1FCE4 20206493 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG177308|UniProtKB=T1FBH4 T1FBH4 20206173 PTHR46576:SF1 BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG173812|UniProtKB=T1F795 T1F795 20204694 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG123161|UniProtKB=T1EGX1 T1EGX1 20195821 PTHR16557:SF12 ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED NUCLEIC ACID DIOXYGENASE ALKBH1 ion binding#GO:0043167;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;dioxygenase activity#GO:0051213;cation binding#GO:0043169;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;binding#GO:0005488;metal ion binding#GO:0046872;ferrous iron binding#GO:0008198;catalytic activity, acting on DNA#GO:0140097;demethylase activity#GO:0032451;iron ion binding#GO:0005506;catalytic activity, acting on RNA#GO:0140098 cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;RNA modification#GO:0009451;metabolic process#GO:0008152;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG158313|UniProtKB=T1EMM7 T1EMM7 20197827 PTHR21461:SF104 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN HELRO|EnsemblGenome=HelroG165615|UniProtKB=T1EX31 T1EX31 20201131 PTHR10544:SF0 60S RIBOSOMAL PROTEIN L28 LARGE RIBOSOMAL SUBUNIT PROTEIN EL28 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG173422|UniProtKB=T1F6T1 T1F6T1 20204530 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174596|UniProtKB=T1F8A4 T1F8A4 20205053 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175946|UniProtKB=T1F9Y1 T1F9Y1 20205630 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175328|UniProtKB=T1F952 T1F952 20205351 PTHR23204:SF10 CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG65374|UniProtKB=T1FY67 T1FY67 20213765 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG190385|UniProtKB=T1FRY3 T1FRY3 20211580 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG190929|UniProtKB=T1FSF6 T1FSF6 20211753 PTHR45617:SF165 LEUCINE RICH REPEAT FAMILY PROTEIN COMMON DPR-INTERACTING PROTEIN-RELATED scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TLR#P01346 HELRO|EnsemblGenome=HelroG167825|UniProtKB=T1EZU4 T1EZU4 20202094 PTHR45969:SF69 RING ZINC FINGER PROTEIN-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 HELRO|EnsemblGenome=HelroG67767|UniProtKB=T1FZ48 T1FZ48 20214096 PTHR12997:SF2 TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 hydrolase#PC00121;phosphatase#PC00181 PI3 kinase pathway#P00048>SHIP#P01200 HELRO|EnsemblGenome=HelroG69003|UniProtKB=T1FZN2 T1FZN2 20214280 PTHR24072:SF411 RHO FAMILY GTPASE RAS-RELATED PROTEIN RAC1-RELATED protein binding#GO:0005515;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;binding#GO:0005488;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of locomotion#GO:0040012;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;actin filament organization#GO:0007015;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;cell morphogenesis involved in neuron differentiation#GO:0048667;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;neuron differentiation#GO:0030182;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;neuron development#GO:0048666;axonogenesis#GO:0007409;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;regulation of developmental process#GO:0050793;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;system development#GO:0048731;supramolecular fiber organization#GO:0097435;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cortical cytoskeleton organization#GO:0030865;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;cell projection organization#GO:0030030;cell differentiation#GO:0030154;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;Rac protein signal transduction#GO:0016601;generation of neurons#GO:0048699;establishment or maintenance of cell polarity#GO:0007163 intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 small GTPase#PC00208;G-protein#PC00020 Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;Axon guidance mediated by netrin#P00009>Rac#P00366;Axon guidance mediated by Slit/Robo#P00008>Rac#P00354;Integrin signalling pathway#P00034>Rac#P00927;Huntington disease#P00029>Rac#P00775;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Ras Pathway#P04393>Rac#P04559;T cell activation#P00053>rac#P01324;EGF receptor signaling pathway#P00018>Rac#P00564;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG184365|UniProtKB=T1FL22 T1FL22 20209521 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG180357|UniProtKB=T1FFT5 T1FFT5 20207684 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173600|UniProtKB=T1F706 T1F706 20204605 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG146310|UniProtKB=T1EJR7 T1EJR7 20196817 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG180133|UniProtKB=T1FFI2 T1FFI2 20207581 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG178121|UniProtKB=T1FCS1 T1FCS1 20206620 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158178|UniProtKB=T1EMK0 T1EMK0 20197800 PTHR48083:SF20 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;lipid modification#GO:0030258;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carnitine metabolic process#GO:0009437;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG163938|UniProtKB=T1EUM8 T1EUM8 20200278 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166378|UniProtKB=T1EY26 T1EY26 20201476 PTHR33167:SF4 TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED HELRO|EnsemblGenome=HelroG106068|UniProtKB=T1EE00 T1EE00 20194802 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG190733|UniProtKB=T1FS90 T1FS90 20211687 PTHR16207:SF11 SET DOMAIN-CONTAINING PROTEIN SET DOMAIN-CONTAINING PROTEIN intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG91852|UniProtKB=T1G898 T1G898 20217295 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG189182|UniProtKB=T1FQR4 T1FQR4 20211161 PTHR12386:SF12 ATP SYNTHASE SUBUNIT ATP SYNTHASE F(0) COMPLEX SUBUNIT G, MITOCHONDRIAL-RELATED proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;oxidative phosphorylation#GO:0006119;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;ribose phosphate biosynthetic process#GO:0046390;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP biosynthetic process#GO:0006754;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine-containing compound metabolic process#GO:0072521;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;proton-transporting ATP synthase complex#GO:0045259;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;transporter complex#GO:1990351;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;respiratory chain complex#GO:0098803;membrane#GO:0016020 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG171105|UniProtKB=T1F3T4 T1F3T4 20203483 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175718|UniProtKB=T1F9K1 T1F9K1 20205500 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;filopodium assembly#GO:0046847;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG178380|UniProtKB=T1FD42 T1FD42 20206741 PTHR13044:SF14 ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 CRYPTOCEPHAL, ISOFORM A gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG171000|UniProtKB=T1F3P2 T1F3P2 20203441 PTHR10457:SF7 MEVALONATE KINASE/GALACTOKINASE GALACTOKINASE-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 metabolic process#GO:0008152;hexose metabolic process#GO:0019318;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065;kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 Fructose galactose metabolism#P02744>Galactokinase#P02960 HELRO|EnsemblGenome=HelroG190613|UniProtKB=T1FS49 T1FS49 20211646 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG157726|UniProtKB=T1EME7 T1EME7 20197747 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG145609|UniProtKB=T1EJL3 T1EJL3 20196763 PTHR24390:SF222 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG107643|UniProtKB=T1EEB9 T1EEB9 20194921 PTHR14467:SF0 ARV1 PROTEIN ARV1 metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;phospholipid metabolic process#GO:0006644 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG171604|UniProtKB=T1F4G2 T1F4G2 20203711 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176469|UniProtKB=T1FAJ4 T1FAJ4 20205843 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191852|UniProtKB=T1FTC8 T1FTC8 20212075 PTHR34929:SF1 ZGC:153157 INAF MOTIF CONTAINING 2 HELRO|EnsemblGenome=HelroG191142|UniProtKB=T1FSN0 T1FSN0 20211827 PTHR18945:SF914 NEUROTRANSMITTER GATED ION CHANNEL NEUROTRANSMITTER-GATED ION-CHANNEL LIGAND-BINDING DOMAIN-CONTAINING PROTEIN synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG188709|UniProtKB=T1FQA3 T1FQA3 20211000 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;symporter activity#GO:0015293;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG104724|UniProtKB=T1EDN4 T1EDN4 20194686 PTHR11540:SF76 MALATE AND LACTATE DEHYDROGENASE MALATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG71763|UniProtKB=T1G0R2 T1G0R2 20214660 PTHR18952:SF278 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG190610|UniProtKB=T1FS47 T1FS47 20211644 PTHR10350:SF6 NUCLEAR PORE COMPLEX PROTEIN NUP155 NUCLEAR PORE COMPLEX PROTEIN NUP155 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 localization within membrane#GO:0051668;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;intracellular protein localization#GO:0008104;chromosome organization#GO:0051276;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;protein transport#GO:0015031;protein import into nucleus#GO:0006606;cellular localization#GO:0051641;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996 organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG180412|UniProtKB=T1FFW5 T1FFW5 20207714 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG163412|UniProtKB=T1EU06 T1EU06 20200056 PTHR15949:SF3 TESTIS-EXPRESSED PROTEIN 264 TESTIS-EXPRESSED PROTEIN 264 cellular response to stress#GO:0033554;process utilizing autophagic mechanism#GO:0061919;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;catabolic process#GO:0009056;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;autophagy#GO:0006914;cellular process#GO:0009987;reticulophagy#GO:0061709;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;macroautophagy#GO:0016236 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;replication fork#GO:0005657;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;autophagosome#GO:0005776;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;vacuole#GO:0005773;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane#GO:0016020;nucleus#GO:0005634;vacuolar membrane#GO:0005774;membraneless organelle#GO:0043228;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG170028|UniProtKB=T1F2K1 T1F2K1 20203050 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG165041|UniProtKB=T1EW65 T1EW65 20200815 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64826|UniProtKB=T1FXZ9 T1FXZ9 20213697 PTHR13651:SF1 PROTEIN ABITRAM PROTEIN ABITRAM binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin monomer binding#GO:0003785;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;regulation of anatomical structure size#GO:0090066;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of actin cytoskeleton organization#GO:0032956;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;dendrite development#GO:0016358;regulation of biological quality#GO:0065008;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of actin filament length#GO:0030832;cell morphogenesis#GO:0000902;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;regulation of plasma membrane bounded cell projection organization#GO:0120035;neurogenesis#GO:0022008;regulation of filopodium assembly#GO:0051489;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of actin filament polymerization#GO:0030833;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament organization#GO:0110053;anatomical structure development#GO:0048856;regulation of cell projection assembly#GO:0060491;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;dendrite morphogenesis#GO:0048813;regulation of supramolecular fiber organization#GO:1902903 intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;lamellipodium#GO:0030027;nucleus#GO:0005634;neuron projection#GO:0043005;cell leading edge#GO:0031252;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425;filopodium#GO:0030175 HELRO|EnsemblGenome=HelroG178169|UniProtKB=T1FCV6 T1FCV6 20206655 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168357|UniProtKB=T1F0G6 T1F0G6 20202316 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189122|UniProtKB=T1FQP4 T1FQP4 20211141 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG175606|UniProtKB=T1F9F0 T1F9F0 20205449 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76642|UniProtKB=T1G2M4 T1G2M4 20215322 PTHR10615:SF222 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT7 catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;chromatin binding#GO:0003682;histone acetyltransferase activity#GO:0004402;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;acetyltransferase activity#GO:0016407;binding#GO:0005488;transcription regulator activity#GO:0140110;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 Alzheimer disease-presenilin pathway#P00004>Tip60#P00137 HELRO|EnsemblGenome=HelroG177501|UniProtKB=T1FBT3 T1FBT3 20206282 PTHR47577:SF4 THAP DOMAIN-CONTAINING PROTEIN 6 TRANSPOSABLE ELEMENT P TRANSPOSASE-LIKE RNASE H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186023|UniProtKB=T1FNK0 T1FNK0 20210397 PTHR11711:SF186 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 11 guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG80744|UniProtKB=T1G448 T1G448 20215846 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG88092|UniProtKB=T1G6Y3 T1G6Y3 20216830 PTHR15440:SF0 XRP2 PROTEIN PROTEIN XRP2 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG193049|UniProtKB=T1FUK4 T1FUK4 20212500 PTHR16200:SF1 RING ZINC FINGER E3 UBIQUITIN-PROTEIN LIGASE PLR-1-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163376|UniProtKB=T1ETZ2 T1ETZ2 20200042 PTHR11361:SF20 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER MUTS PROTEIN HOMOLOG 5 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285;reciprocal homologous recombination#GO:0140527;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;homologous recombination#GO:0035825;reproductive process#GO:0022414;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;reciprocal meiotic recombination#GO:0007131;nuclear division#GO:0000280;cell cycle process#GO:0022402;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;DNA metabolic process#GO:0006259;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;homologous chromosome pairing at meiosis#GO:0007129;cellular component assembly#GO:0022607 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG175003|UniProtKB=T1F8Q1 T1F8Q1 20205200 PTHR11746:SF199 O-METHYLTRANSFERASE DES-METHYL DIF-1 METHYLTRANSFERASE A-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;O-methyltransferase activity#GO:0008171;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168 biosynthetic process#GO:0009058;methylation#GO:0032259;cellular process#GO:0009987;metabolic process#GO:0008152 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG182709|UniProtKB=T1FIM4 T1FIM4 20208673 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG155831|UniProtKB=T1ELN1 T1ELN1 20197481 PTHR21663:SF0 HYPOTHETICAL HEAT DOMAIN-CONTAINING HEAT REPEAT-CONTAINING PROTEIN 5A HELRO|EnsemblGenome=HelroG187875|UniProtKB=T1FPF9 T1FPF9 20210706 PTHR46345:SF8 INVERTED FORMIN-2 INVERTED FORMIN-2 HELRO|EnsemblGenome=HelroG79707|UniProtKB=T1G3S4 T1G3S4 20215722 PTHR10030:SF37 ALPHA-L-FUCOSIDASE TISSUE ALPHA-L-FUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;glycosyl compound catabolic process#GO:1901658;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG164334|UniProtKB=T1EV99 T1EV99 20200499 PTHR36191:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG160549|UniProtKB=T1EQE5 T1EQE5 20198795 PTHR10334:SF517 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG191119|UniProtKB=T1FSM0 T1FSM0 20211817 PTHR14948:SF25 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG101749|UniProtKB=T1ED67 T1ED67 20194519 PTHR24413:SF240 SPECKLE-TYPE POZ PROTEIN PROTEIN ROADKILL enzyme binding#GO:0019899;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;protein binding#GO:0005515 catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of proteolysis#GO:0030162;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG77677|UniProtKB=T1G322 T1G322 20215470 PTHR10868:SF3 SIGMA 1-TYPE OPIOID RECEPTOR-RELATED SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;regulation of cellular response to stress#GO:0080135;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of response to endoplasmic reticulum stress#GO:1905897 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77097|UniProtKB=T1G2T1 T1G2T1 20215379 PTHR47978:SF40 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33 hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367 intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG170631|UniProtKB=T1F395 T1F395 20203294 PTHR11803:SF64 2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA REACTIVE INTERMEDIATE IMINE DEAMINASE A HOMOLOG deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG163021|UniProtKB=T1ETK9 T1ETK9 20199909 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG160934|UniProtKB=T1EQV6 T1EQV6 20198956 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG171945|UniProtKB=T1F4V7 T1F4V7 20203856 PTHR11690:SF300 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED ION CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG174081|UniProtKB=T1F7K8 T1F7K8 20204807 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173298|UniProtKB=T1F6N3 T1F6N3 20204482 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG187930|UniProtKB=T1FPH3 T1FPH3 20210720 PTHR11607:SF72 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;lysosome#GO:0005764;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG70853|UniProtKB=T1G0C9 T1G0C9 20214527 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cellular response to chemical stimulus#GO:0070887;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG188693|UniProtKB=T1FQ96 T1FQ96 20210993 PTHR10126:SF69 TATA-BOX BINDING PROTEIN TATA BOX-BINDING PROTEIN-LIKE 1 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TBP#P01399;General transcription by RNA polymerase I#P00022>TBP#P00657;General transcription by RNA polymerase I#P00022>SL1 complex#P00653;General transcription regulation#P00023>TBP#P00670 HELRO|EnsemblGenome=HelroG73737|UniProtKB=T1G1H8 T1G1H8 20214926 PTHR11048:SF42 PRENYLTRANSFERASES 4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;ketone metabolic process#GO:0042180;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle membrane#GO:0031090;plasma membrane#GO:0005886;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;cell periphery#GO:0071944;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG65485|UniProtKB=T1FY84 T1FY84 20213782 PTHR46242:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG181394|UniProtKB=T1FGY7 T1FGY7 20208086 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG65100|UniProtKB=T1FY33 T1FY33 20213731 PTHR23077:SF202 AAA-FAMILY ATPASE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94 catalytic activity#GO:0003824;polyubiquitin modification-dependent protein binding#GO:0031593;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;modification-dependent protein binding#GO:0140030;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887 ERAD pathway#GO:0036503;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;protein metabolic process#GO:0019538;response to endoplasmic reticulum stress#GO:0034976;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;spindle organization#GO:0007051;establishment of localization#GO:0051234;transport#GO:0006810;autophagosome maturation#GO:0097352;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cytoskeleton organization#GO:0007010;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;autophagy#GO:0006914;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950 organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG142989|UniProtKB=T1EJ84 T1EJ84 20196634 PTHR12290:SF2 CORNICHON-RELATED PHOSPHOPANTOTHENATE--CYSTEINE LIGASE membrane traffic protein#PC00150 Coenzyme A biosynthesis#P02736>Pantothenate cysteine ligase#P02882 HELRO|EnsemblGenome=HelroG172110|UniProtKB=T1F515 T1F515 20203914 PTHR48209:SF4 AGL056WP C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78883|UniProtKB=T1G3G8 T1G3G8 20215616 PTHR14091:SF0 PERIODIC TRYPTOPHAN PROTEIN 1 PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of transcription by RNA polymerase I#GO:0006356 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG84633|UniProtKB=T1G5L3 T1G5L3 20216360 PTHR10283:SF136 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2-LIKE ISOFORM X1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG135381|UniProtKB=T1EI85 T1EI85 20196285 PTHR12300:SF197 HVA22-LIKE PROTEINS LP05237P-RELATED protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 endoplasmic reticulum tubular network organization#GO:0071786;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029 microtubule#GO:0005874;supramolecular fiber#GO:0099512;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;endoplasmic reticulum#GO:0005783;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;endoplasmic reticulum tubular network#GO:0071782 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165287|UniProtKB=T1EWJ5 T1EWJ5 20200945 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG111522|UniProtKB=T1EFC1 T1EFC1 20195273 PTHR23151:SF94 DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;acetyl-CoA metabolic process#GO:0006084;oxoacid metabolic process#GO:0043436;nucleoside phosphate metabolic process#GO:0006753;pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637 oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038;transferase#PC00220 HELRO|EnsemblGenome=HelroG124831|UniProtKB=T1EH31 T1EH31 20195881 PTHR10300:SF14 CALCIPRESSIN PROTEIN SARAH protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG143881|UniProtKB=T1EJC8 T1EJC8 20196678 PTHR22811:SF184 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TMED10 PROTEIN vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG169882|UniProtKB=T1F2E4 T1F2E4 20202994 PTHR15504:SF0 NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45 regulation of biological process#GO:0050789;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of microtubule-based movement#GO:0060632;regulation of microtubule-based process#GO:0032886;regulation of biological quality#GO:0065008;regulation of cell motility#GO:2000145 axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG179247|UniProtKB=T1FEF4 T1FEF4 20207203 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG167533|UniProtKB=T1EZG7 T1EZG7 20201967 PTHR31802:SF40 32 KDA HEAT SHOCK PROTEIN-RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189911|UniProtKB=T1FRH2 T1FRH2 20211419 PTHR13003:SF2 NUP107-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP107 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;biosynthetic process#GO:0009058;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;macromolecule biosynthetic process#GO:0009059;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;protein transport#GO:0015031;protein import into nucleus#GO:0006606;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;gene expression#GO:0010467;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;nuclear pore outer ring#GO:0031080;organelle envelope#GO:0031967 transporter#PC00227 HELRO|EnsemblGenome=HelroG182469|UniProtKB=T1FI89 T1FI89 20208538 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73817|UniProtKB=T1G1I6 T1G1I6 20214934 PTHR46194:SF1 PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED HELRO|EnsemblGenome=HelroG83286|UniProtKB=T1G535 T1G535 20216183 PTHR47979:SF53 DRAB11-RELATED FI07418P GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG136381|UniProtKB=T1EID7 T1EID7 20196337 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG62537|UniProtKB=T1FX19 T1FX19 20213367 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell fate specification#GO:0001708;positive regulation of transcription by RNA polymerase II#GO:0045944;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;positive regulation of macromolecule metabolic process#GO:0010604;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG71177|UniProtKB=T1G0H5 T1G0H5 20214573 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 sodium ion transport#GO:0006814;action potential#GO:0001508;sensory perception of pain#GO:0019233;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;nervous system process#GO:0050877;sensory perception#GO:0007600;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;transport#GO:0006810;system process#GO:0003008;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234 sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG75102|UniProtKB=T1G207 T1G207 20215105 PTHR18934:SF264 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX29 binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG163664|UniProtKB=T1EUC1 T1EUC1 20200171 PTHR22948:SF83 TUDOR DOMAIN CONTAINING PROTEIN TUDOR AND KH DOMAIN-CONTAINING PROTEIN HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190557|UniProtKB=T1FS31 T1FS31 20211628 PTHR12558:SF13 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 27 HOMOLOG enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 mitotic cell cycle phase transition#GO:0044772;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent protein catabolic process#GO:0019941;cell division#GO:0051301;cell cycle#GO:0007049;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of chromosome organization#GO:0033044;mitotic cell cycle process#GO:1903047;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;metaphase/anaphase transition of mitotic cell cycle#GO:0007091;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of cellular component organization#GO:0051128;regulation of chromosome segregation#GO:0051983;metaphase/anaphase transition of cell cycle#GO:0044784;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;cytoplasm#GO:0005737;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG68761|UniProtKB=T1FZJ3 T1FZJ3 20214241 PTHR22847:SF637 WD40 REPEAT PROTEIN WD40 REPEAT-CONTAINING PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG109814|UniProtKB=T1EEW5 T1EEW5 20195117 PTHR11932:SF168 CULLIN CULLIN-1 binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;protein complex scaffold activity#GO:0140378;enzyme binding#GO:0019899;protein binding#GO:0005515;structural molecule activity#GO:0005198;ubiquitin protein ligase binding#GO:0031625 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151 ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>Cul-1#P01239 HELRO|EnsemblGenome=HelroG179985|UniProtKB=T1FFB1 T1FFB1 20207510 PTHR31144:SF1 UPF0602 PROTEIN C4ORF47 CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96 cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 HELRO|EnsemblGenome=HelroG169725|UniProtKB=T1F2A0 T1F2A0 20202950 PTHR45721:SF11 LAMIN DM0-RELATED LAMIN-RELATED structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 intracellular protein localization#GO:0008104;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;nucleus organization#GO:0006997;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;localization#GO:0051179;localization within membrane#GO:0051668;organelle localization#GO:0051640;regulation of macromolecule metabolic process#GO:0060255;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular localization#GO:0051641;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 FAS signaling pathway#P00020>Nuclear Lamin#P00616 HELRO|EnsemblGenome=HelroG77285|UniProtKB=T1G2V7 T1G2V7 20215405 PTHR12560:SF58 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;ceramide metabolic process#GO:0006672 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG170366|UniProtKB=T1F2Z1 T1F2Z1 20203190 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG171015|UniProtKB=T1F3P7 T1F3P7 20203446 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111663|UniProtKB=T1EFD4 T1EFD4 20195286 PTHR15959:SF0 SYNTAXIN-18 SYNTAXIN-18 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;SNARE complex#GO:0031201;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020 membrane traffic protein#PC00150;SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG97488|UniProtKB=T1G9H3 T1G9H3 20217720 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG90622|UniProtKB=T1G7T5 T1G7T5 20217132 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER IP12869P monocarboxylic acid transmembrane transporter activity#GO:0008028;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857 monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG90768|UniProtKB=T1G7V9 T1G7V9 20217156 PTHR10026:SF8 CYCLIN CYCLIN-H cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG193009|UniProtKB=T1FUI4 T1FUI4 20212480 PTHR24028:SF339 CADHERIN-87A CADHERIN DOMAIN-CONTAINING PROTEIN cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG92396|UniProtKB=T1G8F6 T1G8F6 20217353 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG84937|UniProtKB=T1G5Q5 T1G5Q5 20216402 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE GLYCOPROTEIN 3-ALPHA-L-FUCOSYLTRANSFERASE A fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;alpha-(1->3)-fucosyltransferase activity#GO:0046920;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG183965|UniProtKB=T1FKD2 T1FKD2 20209281 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG181750|UniProtKB=T1FHA2 T1FHA2 20208201 PTHR15272:SF0 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG106032|UniProtKB=T1EDZ3 T1EDZ3 20194795 PTHR11472:SF41 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER ATP-DEPENDENT DNA HELICASE DDX11-RELATED helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657 sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG185237|UniProtKB=T1FMJ6 T1FMJ6 20210045 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020;secretory vesicle#GO:0099503;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG79133|UniProtKB=T1G3K6 T1G3K6 20215654 PTHR45810:SF18 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG192366|UniProtKB=T1FTV2 T1FTV2 20212249 PTHR10749:SF8 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG185095|UniProtKB=T1FME1 T1FME1 20209990 PTHR12695:SF2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;response to stimulus#GO:0050896;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIIH core complex#GO:0000439;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transcription factor TFIIH holo complex#GO:0005675;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177130|UniProtKB=T1FB93 T1FB93 20206092 PTHR15069:SF1 PROTEASOME ASSEMBLY CHAPERONE 1 PROTEASOME ASSEMBLY CHAPERONE 1 binding#GO:0005488;protein-containing complex binding#GO:0044877 cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;chaperone-mediated protein complex assembly#GO:0051131;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;protein folding chaperone complex#GO:0101031;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG194195|UniProtKB=T1FVS5 T1FVS5 20212921 PTHR44442:SF2 3-KETO-STEROID REDUCTASE 3-KETO-STEROID REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;primary metabolic process#GO:0044238;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;reductase#PC00198 HELRO|EnsemblGenome=HelroG186283|UniProtKB=T1FNW9 T1FNW9 20210516 PTHR13495:SF0 NEFA-INTERACTING NUCLEAR PROTEIN NIP30 PSME3-INTERACTING PROTEIN intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG74472|UniProtKB=T1G1R5 T1G1R5 20215013 PTHR12429:SF8 NEURALIZED NEURALIZED-LIKE PROTEIN 2 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle cell development#GO:0055001;cell development#GO:0048468;actomyosin structure organization#GO:0031032;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cell differentiation#GO:0030154;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Notch signaling pathway#P00045>Neuralized#P01117 HELRO|EnsemblGenome=HelroG166879|UniProtKB=T1EYP5 T1EYP5 20201695 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188729|UniProtKB=T1FQB0 T1FQB0 20211007 PTHR11223:SF3 EXPORTIN 1/5 EXPORTIN-5 RNA binding#GO:0003723;nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104;nucleic acid binding#GO:0003676;binding#GO:0005488 localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;establishment of localization#GO:0051234;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 transporter#PC00227 HELRO|EnsemblGenome=HelroG168806|UniProtKB=T1F100 T1F100 20202500 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;binding#GO:0005488 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG83020|UniProtKB=T1G4Z2 T1G4Z2 20216140 PTHR10780:SF18 MITOCHONDRIAL CARRIER HOMOLOG LD43650P molecular carrier activity#GO:0140104;membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597 establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;cellular localization#GO:0051641;localization#GO:0051179;protein insertion into mitochondrial outer membrane#GO:0045040;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG114909|UniProtKB=T1EG53 T1EG53 20195555 PTHR43206:SF1 AMINOTRANSFERASE 4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transferase#PC00220;transaminase#PC00216;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>Aminotransferase#P03129;Aminobutyrate degradation#P02726>4-aminobutyrate aminotransferase#P02825;Gamma-aminobutyric acid synthesis#P04384>GABA aminotransferase#P04480 HELRO|EnsemblGenome=HelroG131517|UniProtKB=T1EHW0 T1EHW0 20196160 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 TITIN-LIKE HELRO|EnsemblGenome=HelroG191080|UniProtKB=T1FSK6 T1FSK6 20211803 PTHR14911:SF1 THUMP DOMAIN-CONTAINING U6 SNRNA (GUANINE-N(2))-METHYLTRANSFERASE THUMPD2 methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175 RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG170361|UniProtKB=T1F2Z0 T1F2Z0 20203189 PTHR34253:SF1 PROTEIN LLP HOMOLOG PROTEIN LLP HOMOLOG anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;developmental cell growth#GO:0048588;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;developmental growth involved in morphogenesis#GO:0060560;neuron projection extension#GO:1990138;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;neuron projection development#GO:0031175;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular developmental process#GO:0048869;developmental growth#GO:0048589;cell growth#GO:0016049;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HELRO|EnsemblGenome=HelroG158302|UniProtKB=T1EMM0 T1EMM0 20197820 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159690|UniProtKB=T1EPB2 T1EPB2 20198412 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194907|UniProtKB=T1FWJ8 T1FWJ8 20213193 PTHR11759:SF1 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 SMALL RIBOSOMAL SUBUNIT PROTEIN US11 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;organelle assembly#GO:0070925;translation#GO:0006412;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein-RNA complex organization#GO:0071826;ribosomal small subunit assembly#GO:0000028;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG63519|UniProtKB=T1FXG8 T1FXG8 20213516 PTHR22957:SF653 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN FI17814P1 GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG171375|UniProtKB=T1F472 T1F472 20203621 PTHR24180:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN 39 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG69344|UniProtKB=T1FZT6 T1FZT6 20214334 PTHR24012:SF935 RNA BINDING PROTEIN LD36772P-RELATED RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177678|UniProtKB=T1FC24 T1FC24 20206373 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235;exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG86723|UniProtKB=T1G6G0 T1G6G0 20216657 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;termination of RNA polymerase II transcription#GO:0006369;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181565|UniProtKB=T1FH42 T1FH42 20208141 PTHR13135:SF0 CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26 PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG187018|UniProtKB=T1FP57 T1FP57 20210604 PTHR11679:SF91 VESICLE PROTEIN SORTING-ASSOCIATED PROTEIN ROP protein binding#GO:0005515;syntaxin binding#GO:0019905;binding#GO:0005488;SNARE binding#GO:0000149 synaptic signaling#GO:0099536;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836;regulated exocytosis#GO:0045055;intracellular protein transport#GO:0006886;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;signaling#GO:0023052;cellular localization#GO:0051641;secretion by cell#GO:0032940;protein transport#GO:0015031;macromolecule localization#GO:0033036;vesicle localization#GO:0051648;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;intracellular transport#GO:0046907;calcium-ion regulated exocytosis#GO:0017156;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;anterograde trans-synaptic signaling#GO:0098916;signal release#GO:0023061;organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG182498|UniProtKB=T1FIA0 T1FIA0 20208549 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180151|UniProtKB=T1FFJ0 T1FFJ0 20207589 PTHR16056:SF39 REGULATOR OF MICROTUBULE DYNAMICS PROTEIN TESTIS-EXPRESSED PROTEIN 10 histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG177423|UniProtKB=T1FBN8 T1FBN8 20206237 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105047|UniProtKB=T1EDQ0 T1EDQ0 20194702 PTHR47979:SF150 DRAB11-RELATED RAB2A, MEMBER RAS ONCOGENE FAMILY purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 G-protein#PC00020;small GTPase#PC00208 PDGF signaling pathway#P00047>Ras#P01154 HELRO|EnsemblGenome=HelroG178638|UniProtKB=T1FDH4 T1FDH4 20206873 PTHR13015:SF0 PROTEIN AD-016-RELATED WASH COMPLEX SUBUNIT 3 actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;transport#GO:0006810;exocytosis#GO:0006887;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;export from cell#GO:0140352;actin filament polymerization#GO:0030041;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;secretion by cell#GO:0032940;localization#GO:0051179;secretion#GO:0046903 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG171875|UniProtKB=T1F4S8 T1F4S8 20203827 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE cellular process#GO:0009987;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of establishment or maintenance of cell polarity#GO:0032878;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;localization#GO:0051179 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170769|UniProtKB=T1F3E5 T1F3E5 20203344 PTHR10170:SF11 HUNTINGTON DISEASE PROTEIN HUNTINGTIN, ISOFORM A multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;synaptic vesicle transport#GO:0048489;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle localization#GO:0097479;nervous system development#GO:0007399;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;cell differentiation#GO:0030154;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;transport#GO:0006810;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;neurogenesis#GO:0022008;vesicle cytoskeletal trafficking#GO:0099518;vesicle localization#GO:0051648;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;organelle localization#GO:0051640;anatomical structure development#GO:0048856;localization#GO:0051179;system development#GO:0048731;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of calcium-mediated signaling#GO:0050848 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG180703|UniProtKB=T1FG69 T1FG69 20207818 PTHR14454:SF11 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER SERRANO, ISOFORM F HELRO|EnsemblGenome=HelroG170040|UniProtKB=T1F2K4 T1F2K4 20203053 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77153|UniProtKB=T1G2T6 T1G2T6 20215384 PTHR24044:SF488 NOTCH LIGAND FAMILY MEMBER DELTA-LIKE PROTEIN binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;negative regulation of Notch signaling pathway#GO:0045746;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;Notch signaling pathway#GO:0007219;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71946|UniProtKB=T1G0T3 T1G0T3 20214681 PTHR24067:SF157 UBIQUITIN-CONJUGATING ENZYME E2 FI11905P ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163387|UniProtKB=T1ETZ7 T1ETZ7 20200047 PTHR43243:SF105 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;amino acid transport#GO:0006865 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HELRO|EnsemblGenome=HelroG74077|UniProtKB=T1G1M1 T1G1M1 20214969 PTHR46066:SF2 CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER CHITINASE DOMAIN-CONTAINING PROTEIN 1 oligosaccharide binding#GO:0070492;binding#GO:0005488;carbohydrate binding#GO:0030246 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG167645|UniProtKB=T1EZL9 T1EZL9 20202019 PTHR46734:SF1 TELOMERIC REPEAT-BINDING FACTOR 1 TERF1 TELOMERIC REPEAT-BINDING FACTOR 1 catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;telomerase activity#GO:0003720;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA-directed DNA polymerase activity#GO:0003964;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;organelle organization#GO:0006996;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular component organization#GO:0051129;nucleic acid metabolic process#GO:0090304;negative regulation of organelle organization#GO:0010639;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of chromosome organization#GO:2001251;telomere organization#GO:0032200;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;RNA-templated DNA biosynthetic process#GO:0006278;macromolecule metabolic process#GO:0043170;regulation of telomere maintenance#GO:0032204;telomere maintenance#GO:0000723;chromosome organization#GO:0051276 nuclear telomere cap complex#GO:0000783;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG167944|UniProtKB=T1EZZ8 T1EZZ8 20202148 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG185956|UniProtKB=T1FNH4 T1FNH4 20210371 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG157612|UniProtKB=T1EMD8 T1EMD8 20197738 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG177372|UniProtKB=T1FBK9 T1FBK9 20206208 PTHR22803:SF180 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN-RELATED membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG194947|UniProtKB=T1FWL6 T1FWL6 20213211 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG190628|UniProtKB=T1FS56 T1FS56 20211653 PTHR10099:SF1 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 De novo purine biosynthesis#P02738>Phosphoribosylformylglycinamide synthase#P02898 HELRO|EnsemblGenome=HelroG176814|UniProtKB=T1FAX8 T1FAX8 20205977 PTHR16220:SF1 WD REPEAT PROTEIN 8-RELATED WD REPEAT-CONTAINING PROTEIN WRAP73 mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;nuclear division#GO:0000280;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;spindle assembly#GO:0051225;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG165508|UniProtKB=T1EWY0 T1EWY0 20201080 PTHR48034:SF37 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG182961|UniProtKB=T1FJ00 T1FJ00 20208799 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG90535|UniProtKB=T1G7S9 T1G7S9 20217126 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179721|UniProtKB=T1FF27 T1FF27 20207426 PTHR24041:SF30 MUCIN EGF-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG190647|UniProtKB=T1FS60 T1FS60 20211657 PTHR10665:SF0 RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS SUPPRESSOR OF HAIRLESS PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Angiogenesis#P00005>CSL#P00233;Alzheimer disease-presenilin pathway#P00004>CSL#P00158;Notch signaling pathway#P00045>Su(H)#P01101 HELRO|EnsemblGenome=HelroG164357|UniProtKB=T1EVB3 T1EVB3 20200513 PTHR16501:SF6 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 HELRO|EnsemblGenome=HelroG164578|UniProtKB=T1EVL5 T1EVL5 20200615 PTHR45901:SF3 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY PLAT DOMAINS 1 HELRO|EnsemblGenome=HelroG183260|UniProtKB=T1FJD8 T1FJD8 20208937 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;enzyme activator activity#GO:0008047;heterocyclic compound binding#GO:1901363;molecular function regulator activity#GO:0098772 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG128993|UniProtKB=T1EHR1 T1EHR1 20196111 PTHR45628:SF40 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832 cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;regulation of biological process#GO:0050789;calcium ion import#GO:0070509;calcium ion transmembrane transport#GO:0070588;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022 HELRO|EnsemblGenome=HelroG162973|UniProtKB=T1ETG8 T1ETG8 20199868 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188549|UniProtKB=T1FQ40 T1FQ40 20210937 PTHR24412:SF480 KELCH PROTEIN KELCH-LIKE PROTEIN 8 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188595|UniProtKB=T1FQ56 T1FQ56 20210953 PTHR10337:SF6 SHC TRANSFORMING PROTEIN CENTROSOMAL PROTEIN OF 152 KDA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle assembly#GO:0070925;centriole replication#GO:0007099;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;centrosome cycle#GO:0007098;cell cycle process#GO:0022402 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG157495|UniProtKB=T1EMC3 T1EMC3 20197723 PTHR22850:SF221 WD40 REPEAT FAMILY CHROMATIN ASSEMBLY FACTOR 1 P55 SUBUNIT protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;PcG protein complex#GO:0031519;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG98091|UniProtKB=T1G9K5 T1G9K5 20217751 PTHR11848:SF314 TGF-BETA FAMILY TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 HELRO|EnsemblGenome=HelroG111764|UniProtKB=T1EFE2 T1EFE2 20195294 PTHR10730:SF56 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER GLYCOSYLTRANSFERASE 25 FAMILY MEMBER galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84170|UniProtKB=T1G5F9 T1G5F9 20216306 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192169|UniProtKB=T1FTN4 T1FTN4 20212181 PTHR46669:SF1 LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417 nucleus#GO:0005634;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG71638|UniProtKB=T1G0P5 T1G0P5 20214643 PTHR11267:SF208 T-BOX PROTEIN-RELATED T-BOX PROTEIN 34-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell fate specification#GO:0001708;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG183003|UniProtKB=T1FJ29 T1FJ29 20208828 PTHR14815:SF2 DDB1- AND CUL4-ASSOCIATED FACTOR 17 DDB1- AND CUL4-ASSOCIATED FACTOR 17 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG109340|UniProtKB=T1EES5 T1EES5 20195077 PTHR23237:SF6 NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1 nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515;RNA binding#GO:0003723 telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;gene expression#GO:0010467;RNA processing#GO:0006396;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;rRNA modification#GO:0000154;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;rRNA metabolic process#GO:0016072;RNA-templated DNA biosynthetic process#GO:0006278;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;pseudouridine synthesis#GO:0001522;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;telomere organization#GO:0032200 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG70388|UniProtKB=T1G062 T1G062 20214460 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG111355|UniProtKB=T1EFA5 T1EFA5 20195257 PTHR45965:SF3 INACTIVE RHOMBOID PROTEIN INACTIVE RHOMBOID PROTEIN 1 regulation of response to stimulus#GO:0048583;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signaling#GO:0023051;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of protein secretion#GO:0050708;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 HELRO|EnsemblGenome=HelroG188208|UniProtKB=T1FPS0 T1FPS0 20210817 PTHR10527:SF5 IMPORTIN BETA IMPORTIN-5 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227 HELRO|EnsemblGenome=HelroG99097|UniProtKB=T1G9Q9 T1G9Q9 20217805 PTHR10997:SF8 IMPORTIN-7, 8, 11 EXPORTIN-2 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 protein localization to organelle#GO:0033365;protein transport#GO:0015031;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;protein export from nucleus#GO:0006611;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG73860|UniProtKB=T1G1J5 T1G1J5 20214943 PTHR19965:SF35 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192890|UniProtKB=T1FUE1 T1FUE1 20212437 PTHR23074:SF173 AAA DOMAIN-CONTAINING SPASTIN ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on acid anhydrides#GO:0016817;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;system development#GO:0048731;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;central nervous system neuron differentiation#GO:0021953;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;central nervous system development#GO:0007417;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG158533|UniProtKB=T1EMX5 T1EMX5 20197925 PTHR45749:SF43 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1-LIKE HELRO|EnsemblGenome=HelroG173257|UniProtKB=T1F6L9 T1F6L9 20204468 PTHR45627:SF16 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;adenylate cyclase activity#GO:0004016;lyase activity#GO:0016829 carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;ribose phosphate biosynthetic process#GO:0046390;cyclic purine nucleotide metabolic process#GO:0052652;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 adenylate cyclase#PC00043 HELRO|EnsemblGenome=HelroG167006|UniProtKB=T1EYW0 T1EYW0 20201760 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192108|UniProtKB=T1FTK8 T1FTK8 20212155 PTHR24416:SF647 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cell migration#GO:0016477;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG88163|UniProtKB=T1G6Z2 T1G6Z2 20216839 PTHR20982:SF14 RIBOSOME RECYCLING FACTOR RIBOSOME-RECYCLING FACTOR, MITOCHONDRIAL ribonucleoprotein complex binding#GO:0043021;ribosomal large subunit binding#GO:0043023;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;organelle disassembly#GO:1903008;mitochondrial gene expression#GO:0140053;translational termination#GO:0006415;translation#GO:0006412;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;protein-containing complex disassembly#GO:0032984;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 translation release factor#PC00225 HELRO|EnsemblGenome=HelroG193401|UniProtKB=T1FUY5 T1FUY5 20212631 PTHR12659:SF7 RHO-TYPE GTPASE ACTIVATING PROTEIN CROSSVEINLESS C, ISOFORM C molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047 organelle organization#GO:0006996;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;actin filament-based process#GO:0030029;regulation of signaling#GO:0023051 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG169233|UniProtKB=T1F1L8 T1F1L8 20202718 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166454|UniProtKB=T1EY54 T1EY54 20201504 PTHR47246:SF1 MUCIN-19 MUCIN-19 HELRO|EnsemblGenome=HelroG182155|UniProtKB=T1FHU4 T1FHU4 20208393 PTHR13723:SF313 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 external encapsulating structure organization#GO:0045229;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG188701|UniProtKB=T1FQ99 T1FQ99 20210996 PTHR15660:SF2 BRISC AND BRCA1-A COMPLEX MEMBER 1 BRISC AND BRCA1-A COMPLEX MEMBER 1 signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;regulation of mitotic cell cycle phase transition#GO:1901990;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185429|UniProtKB=T1FMT3 T1FMT3 20210132 PTHR11937:SF31 ACTIN ACTIN-RELATED PROTEIN 3 binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;cytoskeletal protein binding#GO:0008092;structural molecule activity#GO:0005198 actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cortical actin cytoskeleton organization#GO:0030866;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039 Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG185026|UniProtKB=T1FMA8 T1FMA8 20209957 PTHR19923:SF0 WD40 REPEAT PROTEINPRL1/PRL2-RELATED PLEIOTROPIC REGULATOR 1 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG131009|UniProtKB=T1EHU9 T1EHU9 20196149 PTHR15574:SF43 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 5 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of lipid biosynthetic process#GO:0046890;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;negative regulation of cellular process#GO:0048523 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185664|UniProtKB=T1FN41 T1FN41 20210239 PTHR12758:SF25 APOPTOSIS INHIBITOR 5-RELATED APOPTOSIS INHIBITOR 5 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG164648|UniProtKB=T1EVP1 T1EVP1 20200641 PTHR12365:SF7 SPROUTY PROTEIN SPROUTY molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;kinase inhibitor activity#GO:0019210 regulation of cellular response to growth factor stimulus#GO:0090287;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of response to stimulus#GO:0048585;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519;regulation of Ras protein signal transduction#GO:0046578;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 scaffold/adaptor protein#PC00226 FGF signaling pathway#P00021>Spry#P00626;EGF receptor signaling pathway#P00018>Spry#P00541;EGF receptor signaling pathway#P00018>SPRY#G01511 HELRO|EnsemblGenome=HelroG193143|UniProtKB=T1FUN6 T1FUN6 20212532 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230 monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transport#GO:0006810;chloride transport#GO:0006821 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG70342|UniProtKB=T1G051 T1G051 20214449 PTHR46289:SF21 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155295|UniProtKB=T1ELH8 T1ELH8 20197428 PTHR23117:SF13 GUANYLATE KINASE-RELATED GUANYLATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside diphosphate metabolic process#GO:0009132;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;purine ribonucleoside diphosphate metabolic process#GO:0009179;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;ribose phosphate biosynthetic process#GO:0046390 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 kinase#PC00137;transferase#PC00220 De novo purine biosynthesis#P02738>Guanylate kinase#P02904 HELRO|EnsemblGenome=HelroG109833|UniProtKB=T1EEW7 T1EEW7 20195119 PTHR10378:SF50 LIM DOMAIN-BINDING PROTEIN CHIP, ISOFORM B transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG90106|UniProtKB=T1G7L0 T1G7L0 20217057 PTHR22842:SF3 WD40 REPEAT PROTEIN WD REPEAT DOMAIN-CONTAINING PROTEIN 83 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG162788|UniProtKB=T1ET55 T1ET55 20199755 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162163|UniProtKB=T1ESA9 T1ESA9 20199459 PTHR47018:SF4 CXC DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG82669|UniProtKB=T1G4V0 T1G4V0 20216098 PTHR24343:SF576 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of catabolic process#GO:0009896;intracellular protein localization#GO:0008104;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;macromolecule localization#GO:0033036;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular response to glucose starvation#GO:0042149;localization#GO:0051179;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of cell communication#GO:0010646;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;negative regulation of TORC1 signaling#GO:1904262;negative regulation of signal transduction#GO:0009968;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG93398|UniProtKB=T1G8V5 T1G8V5 20217502 PTHR12161:SF5 IST1 FAMILY MEMBER IST1 HOMOLOG intracellular protein localization#GO:0008104;localization#GO:0051179;macromolecule localization#GO:0033036 HELRO|EnsemblGenome=HelroG111906|UniProtKB=T1EFF6 T1EFF6 20195308 PTHR33562:SF27 ATILLA, ISOFORM B-RELATED-RELATED FI02817P-RELATED HELRO|EnsemblGenome=HelroG194721|UniProtKB=T1FWC5 T1FWC5 20213120 PTHR19229:SF275 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2 ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid localization#GO:0010876;macromolecule localization#GO:0033036;transport#GO:0006810;localization#GO:0051179;lipid transport#GO:0006869;establishment of localization#GO:0051234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG188452|UniProtKB=T1FQ02 T1FQ02 20210899 PTHR34031:SF2 CENTROSOMAL PROTEIN OF 162 KDA CENTROSOMAL PROTEIN OF 162 KDA plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;axoneme#GO:0005930;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG80245|UniProtKB=T1G3Z2 T1G3Z2 20215790 PTHR24637:SF437 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162022|UniProtKB=T1ES54 T1ES54 20199404 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69350|UniProtKB=T1FZT8 T1FZT8 20214336 PTHR10639:SF46 CLATHRIN LIGHT CHAIN CLATHRIN LIGHT CHAIN binding#GO:0005488;clathrin binding#GO:0030276;protein binding#GO:0005515 receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987 clathrin vesicle coat#GO:0030125;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;clathrin-coated vesicle membrane#GO:0030665;presynapse#GO:0098793;secretory vesicle#GO:0099503;vesicle coat#GO:0030120;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;synapse#GO:0045202;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane coat#GO:0030117;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150;vesicle coat protein#PC00235 Huntington disease#P00029>Clathrin#P00798;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722 HELRO|EnsemblGenome=HelroG174126|UniProtKB=T1F7N6 T1F7N6 20204835 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184940|UniProtKB=T1FM69 T1FM69 20209918 PTHR11028:SF6 VACUOLAR ATP SYNTHASE SUBUNIT AC39 V-TYPE PROTON ATPASE SUBUNIT D 1 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829 biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453 transmembrane transporter complex#GO:1902495;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;vesicle#GO:0031982;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;endomembrane system#GO:0012505;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;ATPase dependent transmembrane transport complex#GO:0098533;early endosome#GO:0005769;endosome#GO:0005768;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;lysosome#GO:0005764;transporter complex#GO:1990351;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;proton-transporting two-sector ATPase complex#GO:0016469;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;lysosomal membrane#GO:0005765 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG177038|UniProtKB=T1FB60 T1FB60 20206059 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192043|UniProtKB=T1FTJ3 T1FTJ3 20212140 PTHR45676:SF98 RING-H2 FINGER PROTEIN ATL51-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE HELRO|EnsemblGenome=HelroG165225|UniProtKB=T1EWG5 T1EWG5 20200915 PTHR16021:SF28 MANSC DOMAIN CONTAINING PROTEIN 1 OXIDANT-INDUCED CELL-CYCLE ARREST PROTEIN 5 HELRO|EnsemblGenome=HelroG178014|UniProtKB=T1FCL9 T1FCL9 20206568 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG77476|UniProtKB=T1G2Y3 T1G2Y3 20215431 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE lyase activity#GO:0016829;molecular transducer activity#GO:0060089;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653 ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG156683|UniProtKB=T1ELZ9 T1ELZ9 20197599 PTHR10218:SF302 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG164806|UniProtKB=T1EVU1 T1EVU1 20200691 PTHR10454:SF232 CASPASE CASPASE-8 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 programmed cell death#GO:0012501;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;cellular process#GO:0009987;cell death#GO:0008219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG146843|UniProtKB=T1EJU9 T1EJU9 20196849 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG193091|UniProtKB=T1FUM2 T1FUM2 20212518 PTHR35270:SF2 FUSELESS, ISOFORM A SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG82849|UniProtKB=T1G4X4 T1G4X4 20216122 PTHR42904:SF6 NUDIX HYDROLASE, NUDC SUBFAMILY NAD-CAPPED RNA HYDROLASE NUDT12 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787 nucleobase-containing compound metabolic process#GO:0006139;NADP+ metabolic process#GO:0006739;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;pyridine nucleotide catabolic process#GO:0019364;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG170151|UniProtKB=T1F2Q1 T1F2Q1 20203100 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189421|UniProtKB=T1FR18 T1FR18 20211265 PTHR11636:SF5 POU DOMAIN POU DOMAIN MOTIF 3, ISOFORM F sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG99722|UniProtKB=T1G9U7 T1G9U7 20217843 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG163668|UniProtKB=T1EUC2 T1EUC2 20200172 PTHR43048:SF3 METHYLMALONYL-COA EPIMERASE METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL isomerase activity#GO:0016853;catalytic activity#GO:0003824;racemase and epimerase activity#GO:0016854 nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152 isomerase#PC00135;epimerase/racemase#PC00096 Methylmalonyl pathway#P02755>Methylmalonyl-CoA epimerase#P03032 HELRO|EnsemblGenome=HelroG176092|UniProtKB=T1FA47 T1FA47 20205696 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163653|UniProtKB=T1EUB7 T1EUB7 20200167 PTHR11852:SF0 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184984|UniProtKB=T1FM82 T1FM82 20209931 PTHR47385:SF14 CALPONIN TRANSGELIN binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG194412|UniProtKB=T1FW11 T1FW11 20213007 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80894|UniProtKB=T1G469 T1G469 20215867 PTHR45956:SF6 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG164393|UniProtKB=T1EVD4 T1EVD4 20209493 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG189696|UniProtKB=T1FR96 T1FR96 20211343 PTHR24404:SF114 ZINC FINGER PROTEIN RH47711P-RELATED DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG189097|UniProtKB=T1FQM9 T1FQM9 20211126 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG186312|UniProtKB=T1FNY4 T1FNY4 20210531 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177742|UniProtKB=T1FC62 T1FC62 20206411 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED enzyme regulator activity#GO:0030234;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;vesicle#GO:0031982 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG106760|UniProtKB=T1EE47 T1EE47 20194849 PTHR12356:SF3 NUCLEAR MOVEMENT PROTEIN NUDC NUCLEAR MIGRATION PROTEIN NUDC macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG90361|UniProtKB=T1G7P7 T1G7P7 20217094 PTHR14187:SF46 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12A HELRO|EnsemblGenome=HelroG66682|UniProtKB=T1FYP0 T1FYP0 20213938 PTHR23001:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2 translation factor activity#GO:0180051;translation initiation factor binding#GO:0031369;translation initiation factor activity#GO:0003743;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;protein binding#GO:0005515 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;translation#GO:0006412;translational initiation#GO:0006413;cytoplasmic translational initiation#GO:0002183;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG167198|UniProtKB=T1EZ48 T1EZ48 20201848 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG150560|UniProtKB=T1EKG0 T1EKG0 20197060 PTHR10264:SF130 BAND 7 PROTEIN-RELATED STOMATIN-LIKE PROTEIN 1 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;transporter regulator activity#GO:0141108 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG89932|UniProtKB=T1G7J2 T1G7J2 20217039 PTHR17600:SF2 MESODERM DEVELOPMENT CANDIDATE 2 LRP CHAPERONE MESD HELRO|EnsemblGenome=HelroG159178|UniProtKB=T1ENP9 T1ENP9 20198199 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG177711|UniProtKB=T1FC43 T1FC43 20206392 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG176291|UniProtKB=T1FAD4 T1FAD4 20205783 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG63631|UniProtKB=T1FXI5 T1FXI5 20213533 PTHR11610:SF199 LIPASE PANCREATIC TRIACYLGLYCEROL LIPASE-LIKE ISOFORM X2 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity#GO:0016787 lipid catabolic process#GO:0016042;lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG75352|UniProtKB=T1G240 T1G240 20215138 PTHR24044:SF506 NOTCH LIGAND FAMILY MEMBER PROTEIN EYES SHUT HOMOLOG protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG113439|UniProtKB=T1EFS4 T1EFS4 20195426 PTHR45783:SF3 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HELRO|EnsemblGenome=HelroG168035|UniProtKB=T1F033 T1F033 20202183 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG79843|UniProtKB=T1G3U3 T1G3U3 20215741 PTHR10188:SF50 L-ASPARAGINASE N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;lysosome#GO:0005764;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG180180|UniProtKB=T1FFJ7 T1FFJ7 20207596 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG194361|UniProtKB=T1FVZ5 T1FVZ5 20212991 PTHR31802:SF3 32 KDA HEAT SHOCK PROTEIN-RELATED MYOSIN TAIL REGION-INTERACTING PROTEIN MTI1 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG101399|UniProtKB=T1ED44 T1ED44 20194496 PTHR31596:SF1 T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG156474|UniProtKB=T1ELX4 T1ELX4 20197574 PTHR11594:SF0 40S RIBOSOMAL PROTEIN S27 40S RIBOSOMAL PROTEIN S27 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;translation#GO:0006412;nucleic acid biosynthetic process#GO:0141187;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG90638|UniProtKB=T1G7T7 T1G7T7 20217134 PTHR11575:SF50 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE 5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine ribonucleotide catabolic process#GO:0009154;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleotide catabolic process#GO:0006195;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152 membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185;hydrolase#PC00121 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG146354|UniProtKB=T1EJR9 T1EJR9 20196819 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG62245|UniProtKB=T1FWX8 T1FWX8 20213326 PTHR12308:SF83 ANOCTAMIN ANOCTAMIN molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;intramembrane lipid carrier activity#GO:0140303 lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG188186|UniProtKB=T1FPR2 T1FPR2 20210809 PTHR12736:SF21 LANC-LIKE PROTEIN LANC-LIKE PROTEIN 2 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular response to alcohol#GO:1905957;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of abscisic acid-activated signaling pathway#GO:0009787;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of response to alcohol#GO:1901419 HELRO|EnsemblGenome=HelroG70455|UniProtKB=T1G067 T1G067 20214465 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG171664|UniProtKB=T1F4I9 T1F4I9 20203738 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG165647|UniProtKB=T1EX44 T1EX44 20201144 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN CC8L18.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG115347|UniProtKB=T1EG76 T1EG76 20195578 PTHR12027:SF102 WNT RELATED PROTEIN WNT signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;system development#GO:0048731;cell fate commitment#GO:0045165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HELRO|EnsemblGenome=HelroG179806|UniProtKB=T1FF62 T1FF62 20207461 PTHR31366:SF2 UPF0739 PROTEIN C1ORF74 UPF0739 PROTEIN C1ORF74 HELRO|EnsemblGenome=HelroG187748|UniProtKB=T1FPC5 T1FPC5 20210672 PTHR24056:SF233 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 9 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674 RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180408|UniProtKB=T1FFW2 T1FFW2 20207711 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158789|UniProtKB=T1EN96 T1EN96 20198046 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178980|UniProtKB=T1FE02 T1FE02 20207051 PTHR45692:SF1 G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190219|UniProtKB=T1FRS3 T1FRS3 20211520 PTHR23103:SF17 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-LIKE PROTEIN 2 axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG191375|UniProtKB=T1FSX7 T1FSX7 20211924 PTHR31164:SF1 RAD52 MOTIF-CONTAINING PROTEIN 1 RAD52 MOTIF-CONTAINING PROTEIN 1 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HELRO|EnsemblGenome=HelroG109820|UniProtKB=T1EEW6 T1EEW6 20195118 PTHR43157:SF74 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED DEHYDROGENASES, SHORT CHAIN-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG179141|UniProtKB=T1FE84 T1FE84 20207133 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182721|UniProtKB=T1FIN1 T1FIN1 20208680 PTHR22014:SF2 RNA-BINDING PROTEIN 33 RNA-BINDING PROTEIN 33 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 HELRO|EnsemblGenome=HelroG192338|UniProtKB=T1FTU3 T1FTU3 20212240 PTHR23340:SF0 ARGININE/SERINE RICH SPLICING FACTOR SF4/14 SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG166689|UniProtKB=T1EYD3 T1EYD3 20201583 PTHR23287:SF16 RUBY-EYE2-LIKE PROTEIN TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG171441|UniProtKB=T1F4A2 T1F4A2 20203651 PTHR11042:SF202 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EIF-2-ALPHA KINASE GCN2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular response to amino acid starvation#GO:0034198;negative regulation of translation#GO:0017148;cellular response to stress#GO:0033554;regulation of translational initiation#GO:0006446;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194128|UniProtKB=T1FVQ2 T1FVQ2 20212898 PTHR18929:SF240 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096 biosynthetic process#GO:0009058;protein folding#GO:0006457;response to stimulus#GO:0050896;protein maturation#GO:0051604;gene expression#GO:0010467;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 chaperone#PC00072 HELRO|EnsemblGenome=HelroG64113|UniProtKB=T1FXP6 T1FXP6 20213594 PTHR11055:SF79 BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE PAPS SYNTHETASE, ISOFORM D catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;ribose phosphate biosynthetic process#GO:0046390;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137 Sulfate assimilation#P02778>Sulfate adenylyltransferase#P03167 HELRO|EnsemblGenome=HelroG178130|UniProtKB=T1FCT0 T1FCT0 20206629 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191416|UniProtKB=T1FSY8 T1FSY8 20211935 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG188180|UniProtKB=T1FPQ9 T1FPQ9 20210806 PTHR15678:SF6 ANTIGEN MLAA-22-RELATED BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2 HELRO|EnsemblGenome=HelroG182019|UniProtKB=T1FHL8 T1FHL8 20208317 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG162604|UniProtKB=T1ESX1 T1ESX1 20199671 PTHR11042:SF202 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EIF-2-ALPHA KINASE GCN2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;cellular response to stress#GO:0033554;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular response to amino acid starvation#GO:0034198 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG179189|UniProtKB=T1FEB9 T1FEB9 20207168 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG99625|UniProtKB=T1G9U1 T1G9U1 20217837 PTHR43172:SF1 ADENYLOSUCCINATE LYASE ADENYLOSUCCINATE LYASE catalytic activity#GO:0003824;lyase activity#GO:0016829 purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;lyase#PC00144 De novo purine biosynthesis#P02738>Adenosuccinate lyase#P02901;De novo purine biosynthesis#P02738>5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase#P02892 HELRO|EnsemblGenome=HelroG171779|UniProtKB=T1F4N7 T1F4N7 20203786 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185589|UniProtKB=T1FN04 T1FN04 20210203 PTHR13266:SF1 PROTEASOME INHIBITOR PROTEASOME INHIBITOR PI31 SUBUNIT negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of proteasomal protein catabolic process#GO:1901799;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG163156|UniProtKB=T1ETQ8 T1ETQ8 20199958 PTHR10388:SF87 EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1 EUKARYOTIC TRANSLATION INITIATION FACTOR EIF1 ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;nucleic acid binding#GO:0003676;binding#GO:0005488;translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG170463|UniProtKB=T1F335 T1F335 20203234 PTHR15551:SF3 LIM DOMAIN ONLY 7 LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1 myosin binding#GO:0017022;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087;regulation of cell junction assembly#GO:1901888;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of cell-matrix adhesion#GO:0001952;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;regulation of cell adhesion#GO:0030155;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;regulation of actin filament-based process#GO:0032970;positive regulation of actin filament bundle assembly#GO:0032233 actin cytoskeleton#GO:0015629;actomyosin#GO:0042641;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;stress fiber#GO:0001725;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG63797|UniProtKB=T1FXK3 T1FXK3 20213551 PTHR43097:SF16 GLUTAMINE-TRNA LIGASE GLUTAMINE--TRNA LIGASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;cytosol#GO:0005829 aminoacyl-tRNA synthetase#PC00047 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG164209|UniProtKB=T1EV36 T1EV36 20200436 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG82635|UniProtKB=T1G4U4 T1G4U4 20216092 PTHR12603:SF0 CCR4-NOT TRANSCRIPTION COMPLEX RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA stability#GO:0043487;protein metabolic process#GO:0019538;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;CCR4-NOT complex#GO:0030014 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG179990|UniProtKB=T1FFB3 T1FFB3 20207512 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG86204|UniProtKB=T1G684 T1G684 20216581 PTHR10127:SF775 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING METALLOENDOPEPTIDASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG168949|UniProtKB=T1F165 T1F165 20202565 PTHR22806:SF0 NUCLEOPORIN NUP37 P37 -RELATED NUCLEOPORIN NUP37 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nuclear pore outer ring#GO:0031080;nucleus#GO:0005634 transporter#PC00227 HELRO|EnsemblGenome=HelroG168369|UniProtKB=T1F0H7 T1F0H7 20202327 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG192049|UniProtKB=T1FTJ5 T1FTJ5 20212142 PTHR13681:SF24 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED TUDOR DOMAIN-CONTAINING PROTEIN 3 RNA binding#GO:0003723;chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;nucleic acid binding#GO:0003676;histone reader activity#GO:0140566 regulatory ncRNA-mediated heterochromatin formation#GO:0031048;siRNA-mediated heterochromatin formation#GO:0141194;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component assembly#GO:0022607 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG185029|UniProtKB=T1FMB0 T1FMB0 20209959 PTHR46228:SF2 KELCH DOMAIN-CONTAINING PROTEIN KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350) HELRO|EnsemblGenome=HelroG67100|UniProtKB=T1FYW4 T1FYW4 20214012 PTHR21083:SF0 TWISTER AT12351P binding#GO:0005488;protein binding#GO:0005515 cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG104535|UniProtKB=T1EDM2 T1EDM2 20194674 PTHR47020:SF1 HILLARIN HILLARIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG190893|UniProtKB=T1FSE4 T1FSE4 20211741 PTHR12659:SF7 RHO-TYPE GTPASE ACTIVATING PROTEIN CROSSVEINLESS C, ISOFORM C molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cell communication#GO:0010646;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG166833|UniProtKB=T1EYL5 T1EYL5 20201665 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158069|UniProtKB=T1EMJ0 T1EMJ0 20197790 PTHR12629:SF0 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 nucleobase-containing small molecule metabolic process#GO:0055086;nucleotide catabolic process#GO:0009166;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG69677|UniProtKB=T1FZY0 T1FZY0 20214378 PTHR10942:SF0 LEISHMANOLYSIN-LIKE PEPTIDASE LEISHMANOLYSIN-LIKE PEPTIDASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG96746|UniProtKB=T1G9D5 T1G9D5 20217682 PTHR24412:SF450 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN F47D12.7-RELATED enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169148|UniProtKB=T1F1H0 T1F1H0 20202670 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77115|UniProtKB=T1G2T3 T1G2T3 20215381 PTHR11127:SF2 60S RIBOSOMAL PROTEIN L14 LARGE RIBOSOMAL SUBUNIT PROTEIN EL14 structural molecule activity#GO:0005198;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;binding#GO:0005488 ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG109253|UniProtKB=T1EER9 T1EER9 20195071 PTHR10972:SF205 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 1 lipid binding#GO:0008289;steroid binding#GO:0005496;sterol binding#GO:0032934;binding#GO:0005488 plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG113249|UniProtKB=T1EFQ9 T1EFQ9 20195411 PTHR13952:SF5 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;snRNA binding#GO:0017069;RNA binding#GO:0003723 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2-type prespliceosome#GO:0071004;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG162200|UniProtKB=T1ESC5 T1ESC5 20199475 PTHR24230:SF166 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG95849|UniProtKB=T1G984 T1G984 20217631 PTHR11309:SF99 FRIZZLED FRIZZLED-4 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;non-canonical Wnt signaling pathway#GO:0035567;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Frizzled#P01428;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG184649|UniProtKB=T1FLN9 T1FLN9 20209738 PTHR24391:SF27 HISTONE H4 TRANSCRIPTION FACTOR-RELATED ZINC FINGER PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG188344|UniProtKB=T1FPW7 T1FPW7 20210864 PTHR10334:SF517 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG111405|UniProtKB=T1EFA9 T1EFA9 20195261 PTHR19961:SF81 FIMBRIN/PLASTIN FI19014P1 actin binding#GO:0003779;actin filament binding#GO:0051015;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090 actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG190218|UniProtKB=T1FRS2 T1FRS2 20211519 PTHR45737:SF5 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A POLY [ADP-RIBOSE] POLYMERASE HELRO|EnsemblGenome=HelroG156056|UniProtKB=T1ELR1 T1ELR1 20197511 PTHR24072:SF411 RHO FAMILY GTPASE RAS-RELATED PROTEIN RAC1-RELATED ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;intracellular signaling cassette#GO:0141124;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;actin filament organization#GO:0007015;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon guidance#GO:0007411;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;establishment or maintenance of cell polarity#GO:0007163;Rac protein signal transduction#GO:0016601;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;signaling#GO:0023052;cell differentiation#GO:0030154;cell projection organization#GO:0030030;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;cortical cytoskeleton organization#GO:0030865;supramolecular fiber organization#GO:0097435;system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of developmental process#GO:0050793;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;cellular developmental process#GO:0048869;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036 cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cell periphery#GO:0071944;membrane#GO:0016020;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 small GTPase#PC00208;G-protein#PC00020 Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;Axon guidance mediated by netrin#P00009>Rac#P00366;Axon guidance mediated by Slit/Robo#P00008>Rac#P00354;Integrin signalling pathway#P00034>Rac#P00927;Huntington disease#P00029>Rac#P00775;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Ras Pathway#P04393>Rac#P04559;T cell activation#P00053>rac#P01324;EGF receptor signaling pathway#P00018>Rac#P00564;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG76182|UniProtKB=T1G2G3 T1G2G3 20215261 PTHR20902:SF0 41-2 PROTEIN ANTIGEN-RELATED TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5 intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;TRAPPII protein complex#GO:1990071;vesicle#GO:0031982;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG109597|UniProtKB=T1EEV2 T1EEV2 20195104 PTHR10569:SF2 GLYCOGEN DEBRANCHING ENZYME GLYCOGEN DEBRANCHING ENZYME glucosidase activity#GO:0015926;hydrolase activity#GO:0016787;hexosyltransferase activity#GO:0016758;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;transferase activity#GO:0016740;alpha-glucosidase activity#GO:0090599;glycosyltransferase activity#GO:0016757;hydrolase activity, acting on glycosyl bonds#GO:0016798 glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;catabolic process#GO:0009056;glucan catabolic process#GO:0009251;carbohydrate metabolic process#GO:0005975;energy reserve metabolic process#GO:0006112;carbohydrate catabolic process#GO:0016052;glycogen catabolic process#GO:0005980;cellular process#GO:0009987;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG173773|UniProtKB=T1F777 T1F777 20204676 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG104178|UniProtKB=T1EDK1 T1EDK1 20194653 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG185013|UniProtKB=T1FMA0 T1FMA0 20209949 PTHR11630:SF43 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM6 ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 double-strand break repair#GO:0006302;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;nuclear DNA replication#GO:0033260;mitotic DNA replication#GO:1902969;DNA repair#GO:0006281;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049 MCM complex#GO:0042555;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185321|UniProtKB=T1FMN7 T1FMN7 20210086 PTHR43884:SF9 ACYL-COA DEHYDROGENASE COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193089|UniProtKB=T1FUM0 T1FUM0 20212516 PTHR22594:SF56 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARTATE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG98795|UniProtKB=T1G9P8 T1G9P8 20217794 PTHR24023:SF1122 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG155381|UniProtKB=T1ELI1 T1ELI1 20197431 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG104983|UniProtKB=T1EDP5 T1EDP5 20194697 PTHR11780:SF10 NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1 NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG170719|UniProtKB=T1F3C7 T1F3C7 20203326 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG160140|UniProtKB=T1EPV4 T1EPV4 20198604 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174274|UniProtKB=T1F7X3 T1F7X3 20204922 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182854|UniProtKB=T1FIV3 T1FIV3 20208752 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158928|UniProtKB=T1ENF1 T1ENF1 20198101 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88016|UniProtKB=T1G6X4 T1G6X4 20216821 PTHR45864:SF2 SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG PROTEIN PHOSPHATASE SLINGSHOT catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;binding#GO:0005488;actin binding#GO:0003779;protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex assembly#GO:0031333;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 Cytoskeletal regulation by Rho GTPase#P00016>Slingshot#P00509 HELRO|EnsemblGenome=HelroG108638|UniProtKB=T1EEL2 T1EEL2 20195014 PTHR11616:SF338 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 import into cell#GO:0098657;establishment of localization#GO:0051234;organic acid transport#GO:0015849;amino acid transport#GO:0006865;transport#GO:0006810;carboxylic acid transport#GO:0046942;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;glycine transport#GO:0015816;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG86725|UniProtKB=T1G6G2 T1G6G2 20216659 PTHR46690:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG115955|UniProtKB=T1EGC0 T1EGC0 20195622 PTHR23413:SF1 60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N 60S RIBOSOMAL PROTEIN L32 cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG166064|UniProtKB=T1EXP1 T1EXP1 20201341 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG155898|UniProtKB=T1ELN9 T1ELN9 20197489 PTHR45746:SF6 LP21163P LP21163P enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG174915|UniProtKB=T1F8M0 T1F8M0 20205169 PTHR11380:SF16 TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG79024|UniProtKB=T1G3I7 T1G3I7 20215635 PTHR23055:SF60 CALCIUM BINDING PROTEINS CALAXIN ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG71611|UniProtKB=T1G0P0 T1G0P0 20214638 PTHR12159:SF9 G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA N-glycosylase activity#GO:0019104 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA glycosylase#PC00010;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185416|UniProtKB=T1FMS6 T1FMS6 20210125 PTHR11715:SF3 GLYCINE CLEAVAGE SYSTEM H PROTEIN GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG192744|UniProtKB=T1FU93 T1FU93 20212389 PTHR18902:SF31 NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED GOLGIN SUBFAMILY A MEMBER 3-LIKE cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG172144|UniProtKB=T1F524 T1F524 20203923 PTHR10915:SF1 SYNDECAN SYNDECAN cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194010|UniProtKB=T1FVK4 T1FVK4 20212850 PTHR45080:SF47 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell junction organization#GO:0034330;cell adhesion#GO:0007155;synapse organization#GO:0050808;cellular component organization or biogenesis#GO:0071840 axon#GO:0030424;cell body#GO:0044297;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG168724|UniProtKB=T1F0W4 T1F0W4 20202464 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG194270|UniProtKB=T1FVV9 T1FVV9 20212955 PTHR21547:SF0 CLUSTERIN ASSOCIATED PROTEIN 1 CLUSTERIN-ASSOCIATED PROTEIN 1 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intraciliary transport particle B#GO:0030992;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG92232|UniProtKB=T1G8D3 T1G8D3 20217330 PTHR44666:SF1 WD REPEAT-CONTAINING PROTEIN 53 WD REPEAT-CONTAINING PROTEIN 53 HELRO|EnsemblGenome=HelroG162832|UniProtKB=T1ET85 T1ET85 20199785 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG171041|UniProtKB=T1F3Q9 T1F3Q9 20203458 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HELRO|EnsemblGenome=HelroG107583|UniProtKB=T1EEB5 T1EEB5 20194917 PTHR11502:SF6 40S RIBOSOMAL PROTEIN S6 SMALL RIBOSOMAL SUBUNIT PROTEIN ES6 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG191581|UniProtKB=T1FT37 T1FT37 20211984 PTHR39074:SF1 AGAP007547-PA SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG171436|UniProtKB=T1F4A0 T1F4A0 20203649 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71602|UniProtKB=T1G0N9 T1G0N9 20214637 PTHR14167:SF124 SH3 DOMAIN-CONTAINING ENDOPHILIN-A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cytoplasm#GO:0005737;synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;presynapse#GO:0098793;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG69346|UniProtKB=T1FZT7 T1FZT7 20214335 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG91040|UniProtKB=T1G7Z0 T1G7Z0 20217187 PTHR10574:SF274 NETRIN/LAMININ-RELATED USHERIN developmental process#GO:0032502;anatomical structure development#GO:0048856;tissue development#GO:0009888 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG183119|UniProtKB=T1FJ59 T1FJ59 20208858 PTHR14312:SF1 CREB/ATF BZIP TRANSCRIPTION FACTOR BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185871|UniProtKB=T1FND6 T1FND6 20210333 PTHR21646:SF16 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 39 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;regulation of protein stability#GO:0031647;cellular process#GO:0009987;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG158767|UniProtKB=T1EN86 T1EN86 20198036 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174443|UniProtKB=T1F847 T1F847 20204996 PTHR34491:SF156 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED AUGMIN COMPLEX SUBUNIT DGT5 HELRO|EnsemblGenome=HelroG191065|UniProtKB=T1FSJ9 T1FSJ9 20211796 PTHR22741:SF10 P140CAP/SNIP-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157480|UniProtKB=T1EMC0 T1EMC0 20197720 PTHR11024:SF21 NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER PROTEIN SEC13 HOMOLOG regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;protein transport#GO:0015031;protein import into nucleus#GO:0006606;cellular localization#GO:0051641;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;organelle organization#GO:0006996;vesicle-mediated transport#GO:0016192;nucleocytoplasmic transport#GO:0006913;COPII-coated vesicle budding#GO:0090114;nuclear transport#GO:0051169;positive regulation of TOR signaling#GO:0032008;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;protein localization to organelle#GO:0033365;positive regulation of intracellular signal transduction#GO:1902533;transport#GO:0006810;regulation of response to stimulus#GO:0048583;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;vesicle budding from membrane#GO:0006900;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;positive regulation of cellular process#GO:0048522;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;membrane organization#GO:0061024;positive regulation of response to stimulus#GO:0048584 membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;ER to Golgi transport vesicle membrane#GO:0012507;organelle membrane#GO:0031090;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;nuclear pore outer ring#GO:0031080;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle coat#GO:0030120;nuclear envelope#GO:0005635;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;cellular anatomical structure#GO:0110165;organelle#GO:0043226;coated vesicle membrane#GO:0030662;intracellular organelle#GO:0043229;coated membrane#GO:0048475;coated vesicle#GO:0030135 transporter#PC00227 HELRO|EnsemblGenome=HelroG113130|UniProtKB=T1EFQ4 T1EFQ4 20195406 PTHR11895:SF179 TRANSAMIDASE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;mitochondrial gene expression#GO:0140053;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG86108|UniProtKB=T1G675 T1G675 20216572 PTHR11129:SF2 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG77782|UniProtKB=T1G338 T1G338 20215486 PTHR11267:SF181 T-BOX PROTEIN-RELATED OPTOMOTOR-BLIND PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG78359|UniProtKB=T1G3A9 T1G3A9 20215557 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG163568|UniProtKB=T1EU79 T1EU79 20200129 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG132449|UniProtKB=T1EHY6 T1EHY6 20196186 PTHR13370:SF3 RNA METHYLASE-RELATED TRNA (GUANINE(10)-N(2))-METHYLTRANSFERASE TRMT11 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81762|UniProtKB=T1G4I5 T1G4I5 20215983 PTHR10104:SF1 STATHMIN STATHMIN, ISOFORM D cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;protein binding#GO:0005515 system development#GO:0048731;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;regulation of microtubule-based process#GO:0032886;protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;protein depolymerization#GO:0051261;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;microtubule polymerization or depolymerization#GO:0031109;neuron development#GO:0048666;cellular component disassembly#GO:0022411;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG95414|UniProtKB=T1G956 T1G956 20217603 PTHR10459:SF112 DNA LIGASE POLY [ADP-RIBOSE] POLYMERASE 1 pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009 FAS signaling pathway#P00020>PARP#P00600 HELRO|EnsemblGenome=HelroG109477|UniProtKB=T1EEU1 T1EEU1 20195093 PTHR11907:SF0 AMIDOPHOSPHORIBOSYLTRANSFERASE AMIDOPHOSPHORIBOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;transferase#PC00220 De novo purine biosynthesis#P02738>Amidophosphoribosyl transferase#P02905 HELRO|EnsemblGenome=HelroG172570|UniProtKB=T1F5J3 T1F5J3 20204092 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168474|UniProtKB=T1F0M2 T1F0M2 20202372 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG190817|UniProtKB=T1FSB4 T1FSB4 20211711 PTHR21092:SF1 NICASTRIN NICASTRIN macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 Alzheimer disease-presenilin pathway#P00004>Nicastrin#P00115;Notch signaling pathway#P00045>Nicastrin#P01108;Alzheimer disease-amyloid secretase pathway#P00003>Nicastrin#P00095 HELRO|EnsemblGenome=HelroG109225|UniProtKB=T1EER6 T1EER6 20195068 PTHR23235:SF183 KRUEPPEL-LIKE TRANSCRIPTION FACTOR DENDRITIC ARBOR REDUCTION PROTEIN 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG83989|UniProtKB=T1G5C8 T1G5C8 20216275 PTHR11347:SF102 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC PHOSPHODIESTERASE PDE-2-RELATED binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;identical protein binding#GO:0042802;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 cGMP metabolic process#GO:0046068;ribonucleotide catabolic process#GO:0009261;positive regulation of cellular process#GO:0048522;carbohydrate derivative metabolic process#GO:1901135;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;cyclic nucleotide metabolic process#GO:0009187;negative regulation of cellular process#GO:0048523;nucleotide catabolic process#GO:0009166;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;purine ribonucleotide catabolic process#GO:0009154;regulation of mitochondrion organization#GO:0010821;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cell communication#GO:0010646;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;positive regulation of biosynthetic process#GO:0009891;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;positive regulation of biological process#GO:0048518;negative regulation of signal transduction#GO:0009968;positive regulation of macromolecule metabolic process#GO:0010604;cyclic purine nucleotide metabolic process#GO:0052652;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;purine-containing compound metabolic process#GO:0072521;regulation of organelle organization#GO:0033043;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;negative regulation of biological process#GO:0048519;regulation of cellular component organization#GO:0051128;small molecule metabolic process#GO:0044281;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;ribonucleotide metabolic process#GO:0009259;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleotide metabolic process#GO:0009117 mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;organelle outer membrane#GO:0031968;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytosol#GO:0005829;nucleus#GO:0005634;cell periphery#GO:0071944;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;synaptic membrane#GO:0097060;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;organelle inner membrane#GO:0019866;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;outer membrane#GO:0019867;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;mitochondrion#GO:0005739 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG113630|UniProtKB=T1EFU4 T1EFU4 20195446 PTHR12217:SF4 EUKARYOTIC TRANSLATION INITIATION FACTOR 2D EUKARYOTIC TRANSLATION INITIATION FACTOR 2D translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 translational initiation#GO:0006413;translation#GO:0006412;cytoplasmic translational initiation#GO:0002183;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG194142|UniProtKB=T1FVR3 T1FVR3 20212909 PTHR23326:SF1 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 CCR4-NOT complex#GO:0030014;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178415|UniProtKB=T1FD50 T1FD50 20206749 PTHR10075:SF130 BASIGIN RELATED NEURAL CELL ADHESION MOLECULE L1 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG92149|UniProtKB=T1G8C3 T1G8C3 20217320 PTHR19960:SF7 TEKTIN TEKTIN cell motility#GO:0048870;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG177236|UniProtKB=T1FBE0 T1FBE0 20206139 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188596|UniProtKB=T1FQ57 T1FQ57 20210954 PTHR21780:SF0 TRANSMEMBRANE PROTEIN 209 TRANSMEMBRANE PROTEIN 209 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG182781|UniProtKB=T1FIQ2 T1FIQ2 20208701 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 6 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG108136|UniProtKB=T1EEF7 T1EEF7 20194959 PTHR43069:SF2 FUMARYLACETOACETASE FUMARYLACETOACETASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 phenol-containing compound metabolic process#GO:0018958;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;proteinogenic amino acid metabolic process#GO:0170039;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 HELRO|EnsemblGenome=HelroG111560|UniProtKB=T1EFC5 T1EFC5 20195277 PTHR11452:SF95 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG151232|UniProtKB=T1EKJ1 T1EKJ1 20197091 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG93558|UniProtKB=T1G8W5 T1G8W5 20217512 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ATP binding#GO:0005524;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 metabolic process#GO:0008152;cellular process#GO:0009987;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;oxidoreductase complex#GO:1990204;catalytic complex#GO:1902494 oxidoreductase#PC00176;reductase#PC00198 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo purine biosynthesis#P02738>GDP reductase#P02909;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921 HELRO|EnsemblGenome=HelroG79910|UniProtKB=T1G3V1 T1G3V1 20215749 PTHR44117:SF1 INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG NO MECHANORECEPTOR POTENTIAL B, ISOFORM D cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 localization#GO:0051179;non-motile cilium assembly#GO:1905515;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987 non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;ciliary base#GO:0097546;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG193822|UniProtKB=T1FVE2 T1FVE2 20212788 PTHR11360:SF286 MONOCARBOXYLATE TRANSPORTER GH22266P-RELATED carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monocarboxylic acid transmembrane transporter activity#GO:0008028 carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG170313|UniProtKB=T1F2W9 T1F2W9 20203168 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG171364|UniProtKB=T1F465 T1F465 20203614 PTHR16089:SF28 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG63395|UniProtKB=T1FXF4 T1FXF4 20213502 PTHR42679:SF2 S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound metabolic process#GO:0072521;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;nucleotide kinase#PC00172 Purine metabolism#P02769>Nucleoside Phosphorylase#P03115 HELRO|EnsemblGenome=HelroG178970|UniProtKB=T1FDZ6 T1FDZ6 20207045 PTHR18861:SF5 ELKS/RAB6-INTERACTING/CAST PROTEIN PROTEIN BRUCHPILOT structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;cellular component organization#GO:0016043;synapse organization#GO:0050808;cellular process#GO:0009987 presynaptic active zone#GO:0048786;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cell periphery#GO:0071944;cell cortex#GO:0005938;presynapse#GO:0098793 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG65191|UniProtKB=T1FY44 T1FY44 20213742 PTHR46002:SF5 EG:114D9.1 PROTEIN-RELATED EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG162634|UniProtKB=T1ESY3 T1ESY3 20199683 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173357|UniProtKB=T1F6Q3 T1F6Q3 20204502 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 FGF signaling pathway#P00021>RKIP#P00630;EGF receptor signaling pathway#P00018>RKIP#P00548 HELRO|EnsemblGenome=HelroG149692|UniProtKB=T1EKD3 T1EKD3 20197033 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic ion-gated channel activity#GO:0022839;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG176501|UniProtKB=T1FAL2 T1FAL2 20205861 PTHR12264:SF21 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667 general transcription factor#PC00259;RNA metabolism protein#PC00031 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG154629|UniProtKB=T1ELF4 T1ELF4 20197404 PTHR12806:SF0 EAP30 SUBUNIT OF ELL COMPLEX VACUOLAR-SORTING PROTEIN SNF8 late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization to vacuole#GO:0072666;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein transport#GO:0015031;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;endosomal transport#GO:0016197;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;protein localization to vacuole#GO:0072665;localization#GO:0051179;protein metabolic process#GO:0019538;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;macromolecule localization#GO:0033036;endosome transport via multivesicular body sorting pathway#GO:0032509;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG141834|UniProtKB=T1EJ44 T1EJ44 20196594 PTHR24409:SF439 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG80718|UniProtKB=T1G443 T1G443 20215841 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG164816|UniProtKB=T1EVU6 T1EVU6 20200696 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 positive regulation of MAPK cascade#GO:0043410;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of cellular process#GO:0048522;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG137091|UniProtKB=T1EIH4 T1EIH4 20196375 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG178574|UniProtKB=T1FDE7 T1FDE7 20206846 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4 INTERACTING CHROMATIN REMODELING COMPLEX ASSOCIATED PROTEIN, ISOFORM B regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194798|UniProtKB=T1FWF3 T1FWF3 20213148 PTHR21426:SF12 EXOCYST COMPLEX COMPONENT 8 EXOCYST COMPLEX COMPONENT 8 transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;post-Golgi vesicle-mediated transport#GO:0006892;macromolecule localization#GO:0033036;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;Golgi to plasma membrane transport#GO:0006893 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG80095|UniProtKB=T1G3X7 T1G3X7 20215775 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836 synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG179321|UniProtKB=T1FEJ5 T1FEJ5 20207244 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166986|UniProtKB=T1EYU6 T1EYU6 20201746 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;system process#GO:0003008;actin filament organization#GO:0007015;muscle contraction#GO:0006936;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;muscle system process#GO:0003012;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;actin filament#GO:0005884;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG166721|UniProtKB=T1EYF5 T1EYF5 20201605 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG140272|UniProtKB=T1EJ03 T1EJ03 20196553 PTHR42985:SF49 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH20226P transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG156910|UniProtKB=T1EM30 T1EM30 20197630 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CELL DIVISION CYCLE 50, ISOFORM A enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG189399|UniProtKB=T1FR09 T1FR09 20211256 PTHR47705:SF1 AGAP000321-PA WINGED HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63427|UniProtKB=T1FXF8 T1FXF8 20213506 PTHR15371:SF0 TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transmembrane protein transporter activity#GO:0008320 protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;protein transmembrane import into intracellular organelle#GO:0044743;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991 transporter#PC00227;amino acid transporter#PC00046;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG153387|UniProtKB=T1EL63 T1EL63 20197313 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG63586|UniProtKB=T1FXH8 T1FXH8 20213526 PTHR10516:SF443 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FK506-BINDING PROTEIN 59 catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;cis-trans isomerase activity#GO:0016859;catalytic activity#GO:0003824 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG168544|UniProtKB=T1F0P5 T1F0P5 20202395 PTHR11571:SF141 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE P glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG85342|UniProtKB=T1G5V5 T1G5V5 20216452 PTHR12726:SF0 CERAMIDE GLUCOSYLTRANSFERASE CERAMIDE GLUCOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251 lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;glycolipid biosynthetic process#GO:0009247;glycosphingolipid biosynthetic process#GO:0006688 cellular anatomical structure#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG191655|UniProtKB=T1FT65 T1FT65 20212012 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG165256|UniProtKB=T1EWI3 T1EWI3 20200933 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED translation regulator activity#GO:0045182 negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG158491|UniProtKB=T1EMU9 T1EMU9 20197899 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84168|UniProtKB=T1G5F8 T1G5F8 20216305 PTHR10072:SF41 IRON-SULFUR CLUSTER ASSEMBLY PROTEIN IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;iron-sulfur cluster assembly#GO:0016226;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular component biogenesis#GO:0044085 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG112074|UniProtKB=T1EFG7 T1EFG7 20195319 PTHR11827:SF6 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 8 monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG179578|UniProtKB=T1FEW5 T1FEW5 20207364 PTHR14096:SF28 APOLIPOPROTEIN L APOLIPOPROTEIN L, 1-RELATED lipid binding#GO:0008289;binding#GO:0005488 cellular anatomical structure#GO:0110165;membrane#GO:0016020 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG84950|UniProtKB=T1G5Q8 T1G5Q8 20216405 PTHR12446:SF34 TESMIN/TSO1-RELATED PROTEIN LIN-54 HOMOLOG-RELATED regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG184535|UniProtKB=T1FLF0 T1FLF0 20209649 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG194428|UniProtKB=T1FW17 T1FW17 20213013 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG73845|UniProtKB=T1G1J2 T1G1J2 20214940 PTHR21220:SF0 DNA-DEPENDENT METALLOPROTEASE SPRTN DNA-DEPENDENT METALLOPROTEASE SPRTN endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA synthesis involved in DNA replication#GO:0090592;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translesion synthesis#GO:0019985;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG62861|UniProtKB=T1FX63 T1FX63 20213411 PTHR45755:SF6 FAMILY NOT NAMED ZINC TRANSPORTER 7 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;Golgi stack#GO:0005795;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG68122|UniProtKB=T1FZA5 T1FZA5 20214153 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG183196|UniProtKB=T1FJA3 T1FJA3 20208902 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194223|UniProtKB=T1FVU0 T1FVU0 20212936 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG184878|UniProtKB=T1FM43 T1FM43 20209892 PTHR43818:SF11 BCDNA.GH03377 BCDNA.GH03377 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG164841|UniProtKB=T1EVV5 T1EVV5 20200705 PTHR14948:SF25 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86266|UniProtKB=T1G696 T1G696 20216593 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG177845|UniProtKB=T1FCD1 T1FCD1 20206480 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG195063|UniProtKB=T1FWQ1 T1FWQ1 20213246 PTHR21586:SF0 TIPA PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801 HELRO|EnsemblGenome=HelroG157076|UniProtKB=T1EM59 T1EM59 20197659 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG63683|UniProtKB=T1FXJ0 T1FXJ0 20213538 PTHR13463:SF3 PROTEIN C10 PROTEIN C10 post-embryonic development#GO:0009791;developmental process#GO:0032502;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;multicellular organism development#GO:0007275 HELRO|EnsemblGenome=HelroG103740|UniProtKB=T1EDH1 T1EDH1 20194623 PTHR48051:SF81 FAMILY NOT NAMED DISEASE RESISTANCE R13L4_SHOC-2-LIKE LRR DOMAIN-CONTAINING PROTEIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG184920|UniProtKB=T1FM60 T1FM60 20209909 PTHR24068:SF567 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME-RELATED ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096 protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG172124|UniProtKB=T1F520 T1F520 20203919 PTHR44144:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 9 DNAJ HOMOLOG SUBFAMILY C MEMBER 9 binding#GO:0005488;heat shock protein binding#GO:0031072;protein binding#GO:0005515 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG170175|UniProtKB=T1F2R0 T1F2R0 20203109 PTHR23157:SF25 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG168967|UniProtKB=T1F174 T1F174 20202574 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74899|UniProtKB=T1G1X5 T1G1X5 20215073 PTHR10317:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;eukaryotic translation initiation factor 3 complex#GO:0005852 translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG157486|UniProtKB=T1EMC1 T1EMC1 20197721 PTHR43149:SF7 ENOYL-COA HYDRATASE DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824 lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydratase#PC00120 HELRO|EnsemblGenome=HelroG86991|UniProtKB=T1G6K4 T1G6K4 20216701 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG115195|UniProtKB=T1EG71 T1EG71 20195573 PTHR11085:SF1 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7 catalytic activity, acting on a protein#GO:0140096;NAD-dependent protein lysine deacetylase activity#GO:0034979;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone deacetylase activity#GO:0004407;deacylase activity#GO:0160215;deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746 response to stimulus#GO:0050896;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;response to stress#GO:0006950;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular component organization or biogenesis#GO:0071840;cellular response to stress#GO:0033554;DNA damage response#GO:0006974 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG174883|UniProtKB=T1F8K6 T1F8K6 20205155 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to stress#GO:0006950;response to nutrient levels#GO:0031667;response to starvation#GO:0042594;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG130418|UniProtKB=T1EHT8 T1EHT8 20196138 PTHR11814:SF282 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;chloride transport#GO:0006821;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG65821|UniProtKB=T1FYD0 T1FYD0 20213828 PTHR12737:SF9 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE GM09012P hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;arginine metabolic process#GO:0006525;amino acid metabolic process#GO:0006520;biological regulation#GO:0065007;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG195124|UniProtKB=T1FWS1 T1FWS1 20213266 PTHR14211:SF7 GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2 RIBOSOME BIOGENESIS PROTEIN NOP53 nucleic acid binding#GO:0003676;binding#GO:0005488;rRNA binding#GO:0019843;RNA binding#GO:0003723 protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;RNA metabolic process#GO:0016070;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;organelle assembly#GO:0070925;rRNA processing#GO:0006364;protein-RNA complex assembly#GO:0022618;macromolecule biosynthetic process#GO:0009059;ribosomal large subunit assembly#GO:0000027;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG73351|UniProtKB=T1G1D0 T1G1D0 20214878 PTHR43066:SF1 RHOMBOID-RELATED PROTEIN RHOMBOID-RELATED PROTEIN 4 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG166479|UniProtKB=T1EY63 T1EY63 20201513 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169076|UniProtKB=T1F1D3 T1F1D3 20202633 PTHR14390:SF2 G PATCH DOMAIN CONTAINING PROTEIN 3 G PATCH DOMAIN-CONTAINING PROTEIN 3 ISOFORM X1 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 HELRO|EnsemblGenome=HelroG186752|UniProtKB=T1FP29 T1FP29 20210576 PTHR24056:SF472 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG153459|UniProtKB=T1EL76 T1EL76 20197326 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172640|UniProtKB=T1F5P5 T1F5P5 20204144 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG192994|UniProtKB=T1FUH7 T1FUH7 20212473 PTHR12196:SF2 DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN DIPHTHINE--AMMONIA LIGASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;protein modification process#GO:0036211 HELRO|EnsemblGenome=HelroG89736|UniProtKB=T1G7G9 T1G7G9 20217016 PTHR24356:SF210 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE N phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074 HELRO|EnsemblGenome=HelroG67827|UniProtKB=T1FZ60 T1FZ60 20214108 PTHR10114:SF0 60S RIBOSOMAL PROTEIN L36 LARGE RIBOSOMAL SUBUNIT PROTEIN EL36 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG156805|UniProtKB=T1EM14 T1EM14 20197614 PTHR11557:SF0 PORPHOBILINOGEN DEAMINASE PORPHOBILINOGEN DEAMINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;porphyrin-containing compound biosynthetic process#GO:0006779;cellular process#GO:0009987;heme biosynthetic process#GO:0006783;pigment metabolic process#GO:0042440;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;tetrapyrrole biosynthetic process#GO:0033014 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;deaminase#PC00088 Heme biosynthesis#P02746>Hydroxymethylbilane synthase#P02983 HELRO|EnsemblGenome=HelroG96436|UniProtKB=T1G9C1 T1G9C1 20217668 PTHR22878:SF63 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN HEAVY CHAIN 10, AXONEMAL Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG84675|UniProtKB=T1G5L8 T1G5L8 20216365 PTHR21668:SF0 EIF-1A EUKARYOTIC TRANSLATION INITIATION FACTOR 4C translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG155962|UniProtKB=T1ELP8 T1ELP8 20197498 PTHR24412:SF489 KELCH PROTEIN RING CANAL KELCH PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177015|UniProtKB=T1FB53 T1FB53 20206052 PTHR13217:SF13 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG182008|UniProtKB=T1FHL1 T1FHL1 20208310 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171666|UniProtKB=T1F4J0 T1F4J0 20203739 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG146855|UniProtKB=T1EJV2 T1EJV2 20196852 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG87553|UniProtKB=T1G6S1 T1G6S1 20216768 PTHR24243:SF241 G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDES CAPA RECEPTOR neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG188209|UniProtKB=T1FPS1 T1FPS1 20210818 PTHR24418:SF372 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG178084|UniProtKB=T1FCP6 T1FCP6 20206595 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173166|UniProtKB=T1F6H7 T1F6H7 20204426 PTHR32059:SF2 RAB11-BINDING PROTEIN RELCH RAB11-BINDING PROTEIN RELCH transport#GO:0006810;lipid localization#GO:0010876;intracellular transport#GO:0046907;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;sterol transport#GO:0015918;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;intracellular sterol transport#GO:0032366;lipid transport#GO:0006869 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG172030|UniProtKB=T1F4Y8 T1F4Y8 20203887 PTHR20338:SF7 NUCLEAR RESPIRATORY FACTOR 1 MISEXPRESSION SUPPRESSOR OF RAS 3, ISOFORM B transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG194608|UniProtKB=T1FW87 T1FW87 20213083 PTHR18866:SF33 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG105496|UniProtKB=T1EDV7 T1EDV7 20194759 PTHR45808:SF23 RHO GTPASE-ACTIVATING PROTEIN 68F RHO GTPASE-ACTIVATING PROTEIN 68F enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 cellular response to stimulus#GO:0051716;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;negative regulation of cellular process#GO:0048523;regulation of transport#GO:0051049;regulation of localization#GO:0032879 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174;VEGF signaling pathway#P00056>Rac#P01421;Angiogenesis#P00005>Rac#P00245;Cytoskeletal regulation by Rho GTPase#P00016>Rho GAPs#P00520 HELRO|EnsemblGenome=HelroG171168|UniProtKB=T1F3W3 T1F3W3 20203512 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192212|UniProtKB=T1FTP7 T1FTP7 20212194 PTHR19384:SF84 NITRIC OXIDE SYNTHASE-RELATED METHIONINE SYNTHASE REDUCTASE oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;oxidoreductase activity, acting on metal ions#GO:0016722;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038;homocysteine metabolic process#GO:0050667;aspartate family amino acid biosynthetic process#GO:0009067;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;oxoacid metabolic process#GO:0043436;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190223|UniProtKB=T1FRS4 T1FRS4 20211521 PTHR19282:SF565 TETRASPANIN TETRASPANIN-14 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159369|UniProtKB=T1ENY4 T1ENY4 20198284 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG173765|UniProtKB=T1F773 T1F773 20204672 PTHR11177:SF317 CHITINASE GH18 DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;chitinase activity#GO:0004568 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;amino sugar metabolic process#GO:0006040;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;macromolecule catabolic process#GO:0009057;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;chitin metabolic process#GO:0006030;chitin catabolic process#GO:0006032;aminoglycan catabolic process#GO:0006026;amino sugar catabolic process#GO:0046348;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG192681|UniProtKB=T1FU67 T1FU67 20212363 PTHR24006:SF925 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITINYL HYDROLASE 1 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 regulation of protein stability#GO:0031647;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;cell migration#GO:0016477;cell motility#GO:0048870 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG75857|UniProtKB=T1G2B4 T1G2B4 20215212 PTHR45712:SF39 AGAP008170-PA CHAOPTIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG105066|UniProtKB=T1EDQ3 T1EDQ3 20194705 PTHR13799:SF13 NGG1 INTERACTING FACTOR 3 NIF3-LIKE PROTEIN 1 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90564|UniProtKB=T1G7T1 T1G7T1 20217128 PTHR19290:SF102 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED TRANSCRIPTION FACTOR ATOH8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 positive regulation of cellular process#GO:0048522;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG165273|UniProtKB=T1EWJ0 T1EWJ0 20200940 PTHR15934:SF2 RNA 2',3'-CYCLIC PHOSPHODIESTERASE A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;protein kinase A regulatory subunit binding#GO:0034237;protein kinase A binding#GO:0051018;binding#GO:0005488 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176378|UniProtKB=T1FAG5 T1FAG5 20205814 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG67163|UniProtKB=T1FYX6 T1FYX6 20214024 PTHR10250:SF26 MICROSOMAL GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;glutathione transferase activity#GO:0004364;oxidoreductase activity#GO:0016491;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG166157|UniProtKB=T1EXU8 T1EXU8 20201398 PTHR15375:SF26 ACTIVATOR OF S-PHASE KINASE-RELATED PROTEIN CHIFFON kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG88426|UniProtKB=T1G723 T1G723 20216870 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG75995|UniProtKB=T1G2D7 T1G2D7 20215235 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG172579|UniProtKB=T1F5J8 T1F5J8 20204097 PTHR24393:SF190 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG85360|UniProtKB=T1G5V7 T1G5V7 20216454 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG176697|UniProtKB=T1FAS7 T1FAS7 20205926 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG158271|UniProtKB=T1EML4 T1EML4 20197814 PTHR23428:SF70 HISTONE H2B HISTONE H2B chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG154551|UniProtKB=T1ELF1 T1ELF1 20197401 PTHR47979:SF137 DRAB11-RELATED RAB11 ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;secretion by cell#GO:0032940;exocytosis#GO:0006887 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG177274|UniProtKB=T1FBF8 T1FBF8 20206157 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG111980|UniProtKB=T1EFG2 T1EFG2 20195314 PTHR31148:SF1 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;cellular component assembly#GO:0022607;gene expression#GO:0010467;mRNA splice site recognition#GO:0006376;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245 small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;Sm-like protein family complex#GO:0120114;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG71383|UniProtKB=T1G0K6 T1G0K6 20214604 PTHR21320:SF8 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743 chaperone#PC00072 HELRO|EnsemblGenome=HelroG191777|UniProtKB=T1FTB3 T1FTB3 20212060 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98671|UniProtKB=T1G9P3 T1G9P3 20217789 PTHR10257:SF3 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WELL-ROUNDED, ISOFORM B enzyme activator activity#GO:0008047;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629;Wnt signaling pathway#P00057>PP2A#P01438;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG167792|UniProtKB=T1EZT4 T1EZT4 20202084 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER IP12869P carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;localization#GO:0051179;establishment of localization#GO:0051234;monocarboxylic acid transport#GO:0015718 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG191892|UniProtKB=T1FTE3 T1FTE3 20212090 PTHR31802:SF54 32 KDA HEAT SHOCK PROTEIN-RELATED MARTIK, ISOFORM A-RELATED organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG190681|UniProtKB=T1FS71 T1FS71 20211668 PTHR24083:SF87 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR DOMAIN-CONTAINING PROTEIN transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG178717|UniProtKB=T1FDM3 T1FDM3 20206922 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 transferase complex#GO:1990234;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184845|UniProtKB=T1FM28 T1FM28 20209877 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180702|UniProtKB=T1FG68 T1FG68 20207817 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212 HELRO|EnsemblGenome=HelroG85978|UniProtKB=T1G655 T1G655 20216552 PTHR14710:SF2 GEM-ASSOCIATED PROTEIN 6 GEM-ASSOCIATED PROTEIN 6 cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;spliceosomal snRNP assembly#GO:0000387;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 Sm-like protein family complex#GO:0120114;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;SMN complex#GO:0032797;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719 HELRO|EnsemblGenome=HelroG84693|UniProtKB=T1G5M2 T1G5M2 20216369 PTHR11932:SF180 CULLIN CULLIN-3 ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;protein binding#GO:0005515;enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG112973|UniProtKB=T1EFN8 T1EFN8 20195390 PTHR23280:SF34 4.1 G PROTEIN FERM DOMAIN-CONTAINING PROTEIN actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG165589|UniProtKB=T1EX15 T1EX15 20201115 PTHR23350:SF4 PEROXISOME ASSEMBLY PROTEIN 10 PEROXISOME BIOGENESIS FACTOR 2 chaperone#PC00072 HELRO|EnsemblGenome=HelroG62743|UniProtKB=T1FX45 T1FX45 20213393 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87300|UniProtKB=T1G6N9 T1G6N9 20216736 PTHR13677:SF0 LD41638P LD41638P guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;recycling endosome#GO:0055037;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HELRO|EnsemblGenome=HelroG88211|UniProtKB=T1G6Z9 T1G6Z9 20216846 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG178493|UniProtKB=T1FD93 T1FD93 20206792 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG64670|UniProtKB=T1FXX8 T1FXX8 20213676 PTHR15601:SF0 STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4 GEO09675P1 endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG193638|UniProtKB=T1FV79 T1FV79 20212725 PTHR11232:SF2 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER FI05246P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173254|UniProtKB=T1F6L6 T1F6L6 20204465 PTHR13082:SF0 SAP18 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 Hedgehog signaling pathway#P00025>Sap18#P00697 HELRO|EnsemblGenome=HelroG166862|UniProtKB=T1EYN4 T1EYN4 20201684 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161354|UniProtKB=T1ERD7 T1ERD7 20199137 PTHR24366:SF174 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS IG-LIKE DOMAIN-CONTAINING PROTEIN immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG97475|UniProtKB=T1G9G9 T1G9G9 20217716 PTHR23003:SF62 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG167076|UniProtKB=T1EYZ5 T1EYZ5 20201795 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG68072|UniProtKB=T1FZ99 T1FZ99 20214147 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT AT04468P-RELATED ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 transmembrane transport#GO:0055085;potassium ion homeostasis#GO:0055075;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725 ATPase dependent transmembrane transport complex#GO:0098533;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cation-transporting ATPase complex#GO:0090533;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG67514|UniProtKB=T1FZ20 T1FZ20 20214068 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG63562|UniProtKB=T1FXH5 T1FXH5 20213523 PTHR19836:SF31 30S RIBOSOMAL PROTEIN S14 SMALL RIBOSOMAL SUBUNIT PROTEIN US14M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;metabolic process#GO:0008152;translation#GO:0006412 membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG163144|UniProtKB=T1ETQ2 T1ETQ2 20199952 PTHR24034:SF204 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG176211|UniProtKB=T1FAA8 T1FAA8 20205757 PTHR45779:SF7 PEPTIDYLPROLYL ISOMERASE PEPTIDYLPROLYL ISOMERASE catalytic activity#GO:0003824;cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG192286|UniProtKB=T1FTS7 T1FTS7 20212224 PTHR23103:SF17 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-LIKE PROTEIN 2 cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;axon development#GO:0061564;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;central nervous system development#GO:0007417;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG161006|UniProtKB=T1ER00 T1ER00 20199000 PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE triacylglycerol lipase activity#GO:0004806;catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464;triglyceride catabolic process#GO:0019433;metabolic process#GO:0008152;glycerolipid catabolic process#GO:0046503;acylglycerol metabolic process#GO:0006639;neutral lipid catabolic process#GO:0046461;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HELRO|EnsemblGenome=HelroG180820|UniProtKB=T1FGB7 T1FGB7 20207866 PTHR31095:SF3 RIKEN CDNA 9930021J03 GENE BROMODOMAIN CONTAINING 10 HELRO|EnsemblGenome=HelroG184836|UniProtKB=T1FM25 T1FM25 20209874 PTHR11118:SF1 RNA-SPLICING LIGASE RTCB HOMOLOG RNA-SPLICING LIGASE RTCB catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG152110|UniProtKB=T1EKP1 T1EKP1 20197141 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG159975|UniProtKB=T1EPM0 T1EPM0 20198520 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG156339|UniProtKB=T1ELU0 T1ELU0 20197540 PTHR15893:SF17 RIBOSOMAL PROTEIN L27 LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG107587|UniProtKB=T1EEB6 T1EEB6 20194918 PTHR11082:SF31 TRNA-DIHYDROURIDINE SYNTHASE TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG192996|UniProtKB=T1FUH8 T1FUH8 20212474 PTHR13140:SF713 MYOSIN UNCONVENTIONAL MYOSIN ID ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based movement#GO:0030048;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;transport#GO:0006810;actin filament-based process#GO:0030029 plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;microvillus#GO:0005902;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG190614|UniProtKB=T1FS50 T1FS50 20211647 PTHR12191:SF37 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER ZIP8 symporter activity#GO:0015293;transition metal ion transmembrane transporter activity#GO:0046915;monoatomic cation transmembrane transporter activity#GO:0008324;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;zinc ion transmembrane transporter activity#GO:0005385;bicarbonate transmembrane transporter activity#GO:0015106;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG108304|UniProtKB=T1EEI2 T1EEI2 20194984 PTHR10953:SF9 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5 ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;transferase activity, transferring sulphur-containing groups#GO:0016782;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85315|UniProtKB=T1G5V3 T1G5V3 20216450 PTHR28511:SF1 ENDONUCLEASE V ENDONUCLEASE V nucleic acid binding#GO:0003676;binding#GO:0005488;nuclease activity#GO:0004518;RNA binding#GO:0003723;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;single-stranded RNA binding#GO:0003727;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG112981|UniProtKB=T1EFP1 T1EFP1 20195393 PTHR14781:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 56 INTRAFLAGELLAR TRANSPORT PROTEIN 56 binding#GO:0005488;protein-containing complex binding#GO:0044877 cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;intraciliary transport involved in cilium assembly#GO:0035735 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;ciliary base#GO:0097546;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;intraciliary transport particle B#GO:0030992 HELRO|EnsemblGenome=HelroG174894|UniProtKB=T1F8L1 T1F8L1 20205160 PTHR22969:SF17 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>IKK#P00313 HELRO|EnsemblGenome=HelroG192056|UniProtKB=T1FTJ8 T1FTJ8 20212145 PTHR21711:SF0 MITOCHONDRIAL INNER MEMBRANE PROTEASE MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG mitochondrion organization#GO:0007005;biosynthetic process#GO:0009058;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615;metabolic process#GO:0008152;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;proteolysis#GO:0006508 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG182010|UniProtKB=T1FHL2 T1FHL2 20208311 PTHR23110:SF109 BTB DOMAIN TRANSCRIPTION FACTOR VWFA DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG190058|UniProtKB=T1FRM8 T1FRM8 20211475 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P protein refolding#GO:0042026;protein metabolic process#GO:0019538;protein folding#GO:0006457;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;response to heat#GO:0009408 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG88580|UniProtKB=T1G740 T1G740 20216887 PTHR43691:SF11 URIDINE PHOSPHORYLASE FI09636P-RELATED cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 Salvage pyrimidine ribonucleotides#P02775>Uridine phosphorylase#P03152 HELRO|EnsemblGenome=HelroG177647|UniProtKB=T1FC03 T1FC03 20206352 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194679|UniProtKB=T1FWB1 T1FWB1 20213107 PTHR12106:SF27 SORTILIN RELATED PDZ DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG91678|UniProtKB=T1G877 T1G877 20217274 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 HELRO|EnsemblGenome=HelroG153353|UniProtKB=T1EL48 T1EL48 20197373 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108977|UniProtKB=T1EEP5 T1EEP5 20195047 PTHR24035:SF141 MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6 cellular component organization#GO:0016043;cellular process#GO:0009987;endocytosis#GO:0006897;membrane organization#GO:0061024;phagocytosis#GO:0006909;transport#GO:0006810;membrane invagination#GO:0010324;import into cell#GO:0098657;establishment of localization#GO:0051234;apoptotic cell clearance#GO:0043277;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG194945|UniProtKB=T1FWL5 T1FWL5 20213210 PTHR46527:SF1 NUCLEOPORIN-LIKE PROTEIN 2 NUCLEOPORIN NUP42 transporter#PC00227 HELRO|EnsemblGenome=HelroG178715|UniProtKB=T1FDM1 T1FDM1 20206920 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180787|UniProtKB=T1FGA0 T1FGA0 20207849 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG88197|UniProtKB=T1G6Z8 T1G6Z8 20216845 PTHR13703:SF45 SMAD SMAD FAMILY MEMBER 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to growth factor stimulus#GO:0071363;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 SCW signaling pathway#P06216>MED#P06323;GBB signaling pathway#P06214>MED#P06299;TGF-beta signaling pathway#P00052>Co-Smads#P01276;DPP-SCW signaling pathway#P06212>MED#P06265;DPP signaling pathway#P06213>MED#P06279;MYO signaling pathway#P06215>MED#P06311;Activin beta signaling pathway#P06210>MED#P06233;TGF-beta signaling pathway#P00052>RSmads#P01292;BMP/activin signaling pathway-drosophila#P06211>Co-Smad#P06254;ALP23B signaling pathway#P06209>MED#P06221 HELRO|EnsemblGenome=HelroG162572|UniProtKB=T1ESU7 T1ESU7 20199647 PTHR31815:SF1 AGAP005329-PA TRANSMEMBRANE PROTEIN 200C HELRO|EnsemblGenome=HelroG79677|UniProtKB=T1G3S1 T1G3S1 20215719 PTHR34839:SF1 CS DOMAIN-CONTAINING PROTEIN MYOSIN-9-LIKE HELRO|EnsemblGenome=HelroG171341|UniProtKB=T1F452 T1F452 20203601 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG183230|UniProtKB=T1FJC6 T1FJC6 20208925 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG103091|UniProtKB=T1EDE3 T1EDE3 20194595 PTHR24189:SF78 MYOTROPHIN HOMEOBOX PROTEIN WARIAI HELRO|EnsemblGenome=HelroG153340|UniProtKB=T1EL44 T1EL44 20197294 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78986|UniProtKB=T1G3H8 T1G3H8 20215626 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG158569|UniProtKB=T1EMY6 T1EMY6 20197936 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG179571|UniProtKB=T1FEW1 T1FEW1 20207360 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023;binding#GO:0005488;hormone binding#GO:0042562 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177287|UniProtKB=T1FBG5 T1FBG5 20206164 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193117|UniProtKB=T1FUN0 T1FUN0 20212526 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72863|UniProtKB=T1G164 T1G164 20214812 PTHR45620:SF44 PDF RECEPTOR-LIKE PROTEIN-RELATED G-PROTEIN COUPLED RECEPTOR, ORPHAN-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG73217|UniProtKB=T1G1B9 T1G1B9 20214867 PTHR23415:SF4 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG138063|UniProtKB=T1EIR1 T1EIR1 20196461 PTHR11849:SF133 ETS ETS DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ELK#P00890;Parkinson disease#P00049>Elk-1#P01233 HELRO|EnsemblGenome=HelroG174411|UniProtKB=T1F836 T1F836 20204985 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158977|UniProtKB=T1ENG1 T1ENG1 20198111 PTHR46674:SF1 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 protein binding#GO:0005515;binding#GO:0005488;heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879 male gamete generation#GO:0048232;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;spermatogenesis#GO:0007283;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;piRNA processing#GO:0034587;sexual reproduction#GO:0019953;gene expression#GO:0010467;RNA processing#GO:0006396;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gamete generation#GO:0007276;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG66850|UniProtKB=T1FYR9 T1FYR9 20213967 PTHR11947:SF20 PYRUVATE DEHYDROGENASE KINASE BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189876|UniProtKB=T1FRF9 T1FRF9 20211406 PTHR46538:SF3 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84068|UniProtKB=T1G5E2 T1G5E2 20216289 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG172724|UniProtKB=T1F5U9 T1F5U9 20204198 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194054|UniProtKB=T1FVM4 T1FVM4 20212870 PTHR46961:SF8 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG74403|UniProtKB=T1G1Q5 T1G1Q5 20215003 PTHR14074:SF39 HELICASE WITH DEATH DOMAIN-RELATED FANCONI ANEMIA GROUP M PROTEIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG83337|UniProtKB=T1G543 T1G543 20216191 PTHR22847:SF751 WD40 REPEAT PROTEIN WD REPEAT DOMAIN 5B histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463 gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;transcription initiation at RNA polymerase II promoter#GO:0006367;transcription initiation-coupled chromatin remodeling#GO:0045815;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;chromatin remodeling#GO:0006338;DNA-templated transcription initiation#GO:0006352;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891 intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;NSL complex#GO:0044545;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;chromosome#GO:0005694;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG185761|UniProtKB=T1FN92 T1FN92 20210290 PTHR12221:SF6 PESCADILLO - RELATED PESCADILLO HOMOLOG nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;90S preribosome#GO:0030686;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191405|UniProtKB=T1FSY5 T1FSY5 20211932 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG182016|UniProtKB=T1FHL5 T1FHL5 20208314 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG177770|UniProtKB=T1FC83 T1FC83 20206432 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171011|UniProtKB=T1F3P5 T1F3P5 20203444 PTHR45703:SF8 DYNEIN HEAVY CHAIN AAA+ ATPASE DOMAIN-CONTAINING PROTEIN microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG190144|UniProtKB=T1FRQ5 T1FRQ5 20211502 PTHR17598:SF13 DNA POLYMERASE DELTA SUBUNIT 3 DNA POLYMERASE DELTA SUBUNIT 3 catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;DNA-directed DNA polymerase activity#GO:0003887 cellular response to abiotic stimulus#GO:0071214;macromolecule metabolic process#GO:0043170;response to UV#GO:0009411;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;DNA-templated DNA replication#GO:0006261;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA strand elongation involved in DNA replication#GO:0006271;cellular response to radiation#GO:0071478;cellular response to environmental stimulus#GO:0104004;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;replication fork#GO:0005657;replisome#GO:0030894;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;protein-DNA complex#GO:0032993 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG190894|UniProtKB=T1FSE5 T1FSE5 20211742 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG78636|UniProtKB=T1G3D9 T1G3D9 20215587 PTHR12371:SF11 TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 HELRO|EnsemblGenome=HelroG180686|UniProtKB=T1FG61 T1FG61 20207810 PTHR21681:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 regulation of translational initiation#GO:0006446;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG100728|UniProtKB=T1ED15 T1ED15 20194467 PTHR10102:SF28 DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;sequence-specific double-stranded DNA binding#GO:1990837;catalytic activity, acting on RNA#GO:0140098;sequence-specific DNA binding#GO:0043565 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial transcription#GO:0006390;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;RNA polymerase complex#GO:0030880 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG116784|UniProtKB=T1EGH7 T1EGH7 20195679 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG79002|UniProtKB=T1G3I1 T1G3I1 20215629 PTHR24346:SF36 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188864|UniProtKB=T1FQF1 T1FQF1 20211048 PTHR24304:SF4 CYTOCHROME P450 FAMILY 7 CYTOCHROME P450 7B1-LIKE oxidoreductase activity#GO:0016491;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 cholesterol homeostasis#GO:0042632;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;homeostatic process#GO:0042592;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192532|UniProtKB=T1FU21 T1FU21 20212317 PTHR14592:SF15 UNCHARACTERIZED FAM3 ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG109594|UniProtKB=T1EEV1 T1EEV1 20195103 PTHR24115:SF997 KINESIN-RELATED KINESIN HEAVY CHAIN 73, ISOFORM E ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG90408|UniProtKB=T1G7R0 T1G7R0 20217107 PTHR31606:SF1 WW DOMAIN BINDING PROTEIN 2, ISOFORM E WW DOMAIN BINDING PROTEIN 2, ISOFORM E DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG180571|UniProtKB=T1FG21 T1FG21 20207770 PTHR31516:SF22 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;cytoplasmic microtubule#GO:0005881;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG171307|UniProtKB=T1F428 T1F428 20203577 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86945|UniProtKB=T1G6J7 T1G6J7 20216694 PTHR45955:SF1 PHOSPHOACETYLGLUCOSAMINE MUTASE PHOSPHOACETYLGLUCOSAMINE MUTASE isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;intramolecular phosphotransferase activity#GO:0016868 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;organophosphate biosynthetic process#GO:0090407;UDP-N-acetylglucosamine metabolic process#GO:0006047 mutase#PC00160;isomerase#PC00135 HELRO|EnsemblGenome=HelroG69886|UniProtKB=T1FZZ3 T1FZZ3 20214391 PTHR46961:SF8 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG190644|UniProtKB=T1FS59 T1FS59 20211656 PTHR10073:SF59 DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL MLH1, ISOFORM A nuclease activity#GO:0004518;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;DNA endonuclease activity#GO:0004520;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;mismatch repair#GO:0006298;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG189222|UniProtKB=T1FQT6 T1FQT6 20211183 PTHR23120:SF0 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 1 ISOFORM X1 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG117141|UniProtKB=T1EGK5 T1EGK5 20195706 PTHR46756:SF29 TRANSGELIN GAS2-LIKE PROTEIN PICKLED EGGS binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;protein localization to cytoskeleton#GO:0044380;cellular component organization#GO:0016043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;actin filament-based process#GO:0030029;microtubule bundle formation#GO:0001578;regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;protein localization to microtubule cytoskeleton#GO:0072698;intracellular protein localization#GO:0008104;actin filament organization#GO:0007015;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;microtubule end#GO:1990752;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;actin filament bundle#GO:0032432;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;actomyosin#GO:0042641;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;stress fiber#GO:0001725;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG166123|UniProtKB=T1EXT5 T1EXT5 20201385 PTHR10264:SF136 BAND 7 PROTEIN-RELATED BAND 7 DOMAIN-CONTAINING PROTEIN transporter regulator activity#GO:0141108;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG181270|UniProtKB=T1FGT7 T1FGT7 20208036 PTHR24085:SF4 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR38-RELATED RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;nuclear receptor binding#GO:0016922;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription factor binding#GO:0008134 cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to chemical#GO:0042221;response to peptide hormone#GO:0043434;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to hormone#GO:0009725;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG194432|UniProtKB=T1FW18 T1FW18 20213014 PTHR10242:SF2 8-OXOGUANINE DNA GLYCOSYLASE N-GLYCOSYLASE_DNA LYASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA N-glycosylase activity#GO:0019104;hydrolase activity#GO:0016787;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on glycosyl bonds#GO:0016798 macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;base-excision repair#GO:0006284;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG66362|UniProtKB=T1FYK2 T1FYK2 20213900 PTHR12241:SF161 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017;microtubule bundle formation#GO:0001578 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG177767|UniProtKB=T1FC80 T1FC80 20206429 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG70373|UniProtKB=T1G055 T1G055 20214453 PTHR24351:SF216 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192411|UniProtKB=T1FTX6 T1FTX6 20212273 PTHR21470:SF29 RAB6-INTERACTING PROTEIN GORAB RAB6-INTERACTING GOLGIN cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515 HELRO|EnsemblGenome=HelroG132748|UniProtKB=T1EHZ3 T1EHZ3 20196193 PTHR24392:SF56 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG177819|UniProtKB=T1FCB6 T1FCB6 20206465 PTHR24020:SF20 COLLAGEN ALPHA PH DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG165853|UniProtKB=T1EXD1 T1EXD1 20201231 PTHR36168:SF1 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE AAA PROTEIN C-TERMINAL WINGED HELIX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165611|UniProtKB=T1EX28 T1EX28 20201128 PTHR10574:SF440 NETRIN/LAMININ-RELATED LAMININ SUBUNIT ALPHA LAM-3 developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron projection development#GO:0031175;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;tissue development#GO:0009888;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG167615|UniProtKB=T1EZK4 T1EZK4 20202004 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG161350|UniProtKB=T1ERD6 T1ERD6 20199136 PTHR47027:SF25 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62550|UniProtKB=T1FX22 T1FX22 20213370 PTHR12484:SF4 B-LYMPHOCYTE ANTIGEN-RELATED A-KINASE ANCHOR PROTEIN 17A HELRO|EnsemblGenome=HelroG187998|UniProtKB=T1FPJ1 T1FPJ1 20210738 PTHR21014:SF6 PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152 endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;lysosome#GO:0005764;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;phagocytic vesicle#GO:0045335;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG76282|UniProtKB=T1G2H8 T1G2H8 20215276 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG139735|UniProtKB=T1EIZ4 T1EIZ4 20196544 PTHR45992:SF12 EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED EUKARYOTIC ELONGATION FACTOR 2 KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;postsynapse#GO:0098794;cell junction#GO:0030054;postsynaptic density#GO:0014069 Oxidative stress response#P00046>eEF2K#P01127;p38 MAPK pathway#P05918>eEF2K#P06022 HELRO|EnsemblGenome=HelroG173612|UniProtKB=T1F718 T1F718 20204617 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG115175|UniProtKB=T1EG70 T1EG70 20195572 PTHR24043:SF13 SCAVENGER RECEPTOR CLASS F EGF-LIKE DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192918|UniProtKB=T1FUF5 T1FUF5 20212451 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG182652|UniProtKB=T1FIJ5 T1FIJ5 20208644 PTHR37162:SF15 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175370|UniProtKB=T1F972 T1F972 20205371 PTHR20961:SF167 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG114833|UniProtKB=T1EG47 T1EG47 20195549 PTHR11347:SF179 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC PHOSPHODIESTERASE PDE-3-RELATED cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG192521|UniProtKB=T1FU18 T1FU18 20212314 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104;protein localization to plasma membrane#GO:0072659;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172658|UniProtKB=T1F5Q9 T1F5Q9 20204158 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160608|UniProtKB=T1EQH5 T1EQH5 20198825 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P response to heat#GO:0009408;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;response to stimulus#GO:0050896;protein folding#GO:0006457;protein metabolic process#GO:0019538;protein refolding#GO:0042026 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG63203|UniProtKB=T1FXC2 T1FXC2 20213470 PTHR22851:SF0 U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN DDB1- AND CUL4-ASSOCIATED FACTOR 13 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188380|UniProtKB=T1FPX8 T1FPX8 20210875 PTHR47020:SF1 HILLARIN HILLARIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG67330|UniProtKB=T1FYZ8 T1FYZ8 20214046 PTHR30521:SF0 DEFERROCHELATASE/PEROXIDASE DYP-TYPE PEROXIDASE FAMILY PROTEIN oxidoreductase activity#GO:0016491;heme binding#GO:0020037;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;tetrapyrrole binding#GO:0046906;binding#GO:0005488 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 peroxidase#PC00180 HELRO|EnsemblGenome=HelroG188408|UniProtKB=T1FPY7 T1FPY7 20210884 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG190880|UniProtKB=T1FSD8 T1FSD8 20211735 PTHR24180:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN 39 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG140014|UniProtKB=T1EIZ7 T1EIZ7 20196547 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FI18312P1 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG125603|UniProtKB=T1EH69 T1EH69 20195919 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG81743|UniProtKB=T1G4I3 T1G4I3 20215981 PTHR11348:SF17 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN integrin binding#GO:0005178;carbohydrate derivative binding#GO:0097367;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;signaling receptor binding#GO:0005102;glycosaminoglycan binding#GO:0005539 regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell adhesion#GO:0007155;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HELRO|EnsemblGenome=HelroG172976|UniProtKB=T1F684 T1F684 20204333 PTHR10015:SF427 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK FACTOR PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG126196|UniProtKB=T1EH85 T1EH85 20195935 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG177566|UniProtKB=T1FBV9 T1FBV9 20206308 PTHR24213:SF9 ACTIN-BINDING LIM PROTEIN UNCOORDINATED 115A, ISOFORM B-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;lamellipodium assembly#GO:0030032;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Axon guidance mediated by netrin#P00009>Ablim#P00358 HELRO|EnsemblGenome=HelroG180714|UniProtKB=T1FG72 T1FG72 20207821 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG167294|UniProtKB=T1EZ82 T1EZ82 20201882 PTHR10579:SF43 CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN ion channel#PC00133 HELRO|EnsemblGenome=HelroG177496|UniProtKB=T1FBS8 T1FBS8 20206277 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92352|UniProtKB=T1G8E8 T1G8E8 20217345 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG190293|UniProtKB=T1FRV4 T1FRV4 20211551 PTHR23176:SF133 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN GTPASE-ACTIVATING PROTEIN PAC-1 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG169116|UniProtKB=T1F1F2 T1F1F2 20202652 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189432|UniProtKB=T1FR19 T1FR19 20211266 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175194|UniProtKB=T1F8Z6 T1F8Z6 20205295 PTHR23285:SF7 RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 LD09246P1 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG107225|UniProtKB=T1EE88 T1EE88 20194890 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;epidermis development#GO:0008544;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG66792|UniProtKB=T1FYR0 T1FYR0 20213958 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG155691|UniProtKB=T1ELK6 T1ELK6 20197456 PTHR47448:SF6 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN MITOGEN-ACTIVATED PROTEIN KINASE KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG75568|UniProtKB=T1G266 T1G266 20215164 PTHR10972:SF136 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN steroid binding#GO:0005496;lipid binding#GO:0008289;sterol binding#GO:0032934;binding#GO:0005488 membrane#GO:0016020;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG115846|UniProtKB=T1EGB3 T1EGB3 20195615 PTHR24192:SF3 ANKYRIN REPEAT DOMAIN 40 ANKYRIN REPEAT DOMAIN 40 HELRO|EnsemblGenome=HelroG165758|UniProtKB=T1EX94 T1EX94 20201194 PTHR45797:SF1 RAD54-LIKE HELICASE ARIP4 transcription regulator activity#GO:0140110;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG77631|UniProtKB=T1G312 T1G312 20215460 PTHR20208:SF10 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1 catalytic activity, acting on a nucleic acid#GO:0140640;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724 chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009;endodeoxyribonuclease#PC00093 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG162703|UniProtKB=T1ET10 T1ET10 20199710 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170959|UniProtKB=T1F3M5 T1F3M5 20203424 PTHR24416:SF349 TYROSINE-PROTEIN KINASE RECEPTOR INACTIVE TYROSINE-PROTEIN KINASE RYK phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of intracellular signal transduction#GO:1902531 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170340|UniProtKB=T1F2X9 T1F2X9 20203178 PTHR21420:SF3 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 protein modifying enzyme#PC00260 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG63814|UniProtKB=T1FXK7 T1FXK7 20213555 PTHR12241:SF145 TUBULIN POLYGLUTAMYLASE TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 5 binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;tubulin binding#GO:0015631;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG96072|UniProtKB=T1G9A1 T1G9A1 20217648 PTHR12131:SF7 ATP-DEPENDENT RNA AND DNA HELICASE EXOSOME RNA HELICASE MTR4 ATP-dependent activity#GO:0140657;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 ribosome biogenesis#GO:0042254;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound catabolic process#GO:0034655;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG180343|UniProtKB=T1FFS5 T1FFS5 20207674 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185177|UniProtKB=T1FMH1 T1FMH1 20210020 PTHR10977:SF3 DIPHOSPHOMEVALONATE DECARBOXYLASE DIPHOSPHOMEVALONATE DECARBOXYLASE carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829 nucleoside phosphate metabolic process#GO:0006753;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;isoprenoid metabolic process#GO:0006720;organophosphate biosynthetic process#GO:0090407;isoprenoid biosynthetic process#GO:0008299;acetyl-CoA metabolic process#GO:0006084;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;lyase#PC00144 Cholesterol biosynthesis#P00014>Diphosphomevalonate decarboxylase#P00496 HELRO|EnsemblGenome=HelroG185264|UniProtKB=T1FMK9 T1FMK9 20210058 PTHR45850:SF1 SORTING NEXIN FAMILY MEMBER SORTING NEXIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180449|UniProtKB=T1FFX7 T1FFX7 20207726 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG107709|UniProtKB=T1EEC4 T1EEC4 20194926 PTHR10026:SF144 CYCLIN CYCLIN-K enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase activator activity#GO:0030295 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557 organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911 kinase activator#PC00138;kinase modulator#PC00140 Cell cycle#P00013>CdkC#P00489 HELRO|EnsemblGenome=HelroG108960|UniProtKB=T1EEP3 T1EEP3 20195045 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164855|UniProtKB=T1EVW2 T1EVW2 20200712 PTHR23312:SF8 ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED ARMADILLO REPEAT-CONTAINING PROTEIN 5 anatomical structure morphogenesis#GO:0009653;developmental process#GO:0032502;anatomical structure development#GO:0048856 HELRO|EnsemblGenome=HelroG177956|UniProtKB=T1FCI5 T1FCI5 20206534 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165794|UniProtKB=T1EXA6 T1EXA6 20201206 PTHR11614:SF198 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 cellular anatomical structure#GO:0110165;membrane#GO:0016020 lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG194276|UniProtKB=T1FVW0 T1FVW0 20212956 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488;protein binding#GO:0005515 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179552|UniProtKB=T1FEV2 T1FEV2 20207351 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190381|UniProtKB=T1FRY1 T1FRY1 20211578 PTHR24251:SF30 OVOCHYMASE-RELATED CUB DOMAIN-CONTAINING PROTEIN protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG187411|UniProtKB=T1FP97 T1FP97 20210644 PTHR11034:SF40 N-MYC DOWNSTREAM REGULATED BCDNA.GH02439 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG172487|UniProtKB=T1F5D9 T1F5D9 20204038 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG97481|UniProtKB=T1G9H0 T1G9H0 20217717 PTHR23065:SF11 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 SYNDAPIN, ISOFORM C phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of localization#GO:0032879;regulation of transport#GO:0051049;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840;regulation of endocytosis#GO:0030100 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG176045|UniProtKB=T1FA28 T1FA28 20205677 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN FUCOLECTIN-6-LIKE HELRO|EnsemblGenome=HelroG83285|UniProtKB=T1G534 T1G534 20216182 PTHR45843:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chaperone#PC00072 HELRO|EnsemblGenome=HelroG178125|UniProtKB=T1FCS5 T1FCS5 20206624 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR ALLATOSTATIN A RECEPTOR 2, ISOFORM A molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169371|UniProtKB=T1F1V1 T1F1V1 20202801 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194445|UniProtKB=T1FW23 T1FW23 20213019 PTHR42996:SF1 PHOSPHATE-BINDING PROTEIN PSTS PHOSPHATE-BINDING PROTEIN PSTS establishment of localization#GO:0051234;localization#GO:0051179;phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698;transport#GO:0006810 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG188331|UniProtKB=T1FPW2 T1FPW2 20210859 PTHR23113:SF249 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;anatomical structure development#GO:0048856;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG165064|UniProtKB=T1EW86 T1EW86 20200836 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191659|UniProtKB=T1FT68 T1FT68 20212015 PTHR12228:SF0 TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7 transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HELRO|EnsemblGenome=HelroG191012|UniProtKB=T1FSH9 T1FSH9 20211776 PTHR31220:SF10 HYCCIN RELATED GH21176P intracellular protein localization#GO:0008104;metabolic process#GO:0008152;protein localization to cell periphery#GO:1990778;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;cellular localization#GO:0051641;localization#GO:0051179;phosphatidylinositol phosphate biosynthetic process#GO:0046854;localization within membrane#GO:0051668;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG188231|UniProtKB=T1FPS8 T1FPS8 20210825 PTHR17613:SF14 CEREBRAL PROTEIN-11-RELATED DEMENTIN, ISOFORM H cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG181964|UniProtKB=T1FHJ0 T1FHJ0 20208289 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179171|UniProtKB=T1FEA7 T1FEA7 20207156 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182523|UniProtKB=T1FIB4 T1FIB4 20208563 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109307|UniProtKB=T1EES2 T1EES2 20195074 PTHR16228:SF7 DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41 SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG156500|UniProtKB=T1ELX7 T1ELX7 20197577 PTHR20994:SF0 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6 protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977;molecular carrier activity#GO:0140104 endomembrane system organization#GO:0010256;membrane organization#GO:0061024;macroautophagy#GO:0016236;protein insertion into membrane#GO:0051205;cellular component assembly#GO:0022607;tail-anchored membrane protein insertion into ER membrane#GO:0071816;autophagy#GO:0006914;establishment of protein localization#GO:0045184;autophagosome organization#GO:1905037;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;intracellular protein localization#GO:0008104;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;metabolic process#GO:0008152;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;organelle assembly#GO:0070925 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;EMC complex#GO:0072546;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG182503|UniProtKB=T1FIA2 T1FIA2 20208551 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193707|UniProtKB=T1FVA3 T1FVA3 20212749 PTHR23044:SF84 3'-5' EXONUCLEASE ERI1-RELATED ERI1 EXORIBONUCLEASE 2 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;negative regulation of biological process#GO:0048519;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of gene silencing by regulatory ncRNA#GO:0060966;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of cellular component organization#GO:0051129;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;regulation of chromatin organization#GO:1902275;positive regulation of biosynthetic process#GO:0009891;rRNA processing#GO:0006364 exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG159244|UniProtKB=T1ENS6 T1ENS6 20198226 PTHR45857:SF4 FORMIN-LIKE PROTEIN MULTIPLE WING HAIRS, ISOFORM C HELRO|EnsemblGenome=HelroG169921|UniProtKB=T1F2G2 T1F2G2 20203012 PTHR11142:SF5 PSEUDOURIDYLATE SYNTHASE TRNA PSEUDOURIDINE(38_39) SYNTHASE catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;isomerase activity#GO:0016853 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;tRNA modification#GO:0006400;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA modification#GO:0016556;pseudouridine synthesis#GO:0001522;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 lyase#PC00144 HELRO|EnsemblGenome=HelroG181660|UniProtKB=T1FH77 T1FH77 20208176 PTHR32463:SF0 L-FUCOSE KINASE L-FUCOSE KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-sugar metabolic process#GO:0009225;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG109647|UniProtKB=T1EEV4 T1EEV4 20195106 PTHR13937:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;eukaryotic translation initiation factor 3 complex#GO:0005852 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG83677|UniProtKB=T1G590 T1G590 20216237 PTHR42985:SF49 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH20226P symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG166106|UniProtKB=T1EXR8 T1EXR8 20201368 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN hormone binding#GO:0042562;binding#GO:0005488;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173643|UniProtKB=T1F730 T1F730 20204629 PTHR11177:SF317 CHITINASE GH18 DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;chitinase activity#GO:0004568;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;amino sugar metabolic process#GO:0006040;chitin metabolic process#GO:0006030;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;amino sugar catabolic process#GO:0046348;chitin catabolic process#GO:0006032;aminoglycan catabolic process#GO:0006026 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 glycosidase#PC00110;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157806|UniProtKB=T1EMG0 T1EMG0 20197760 PTHR10853:SF11 PELOTA PROTEIN PELOTA HOMOLOG molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;translational elongation#GO:0006414;macromolecule catabolic process#GO:0009057;gene expression#GO:0010467;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;rescue of stalled cytosolic ribosome#GO:0072344;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;protein metabolic process#GO:0019538;translation#GO:0006412;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 translation release factor#PC00225 HELRO|EnsemblGenome=HelroG187538|UniProtKB=T1FPA6 T1FPA6 20210653 PTHR10644:SF27 DNA REPAIR/RNA PROCESSING CPSF FAMILY DNA DAMAGE-BINDING PROTEIN 1 proteasomal protein catabolic process#GO:0010498;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;DNA repair#GO:0006281;metabolic process#GO:0008152;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;site of double-strand break#GO:0035861;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG77267|UniProtKB=T1G2V4 T1G2V4 20216672 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157739|UniProtKB=T1EMF1 T1EMF1 20197751 PTHR11918:SF45 RADICAL SAM PROTEINS THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG123705|UniProtKB=T1EGY6 T1EGY6 20195836 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG174326|UniProtKB=T1F805 T1F805 20204954 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187800|UniProtKB=T1FPD9 T1FPD9 20210686 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG137390|UniProtKB=T1EIK2 T1EIK2 20196402 PTHR24333:SF17 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX PROTEIN UNPLUGGED-RELATED helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG89219|UniProtKB=T1G7A5 T1G7A5 20216952 PTHR19300:SF65 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG175168|UniProtKB=T1F8Y4 T1F8Y4 20205283 PTHR11533:SF174 PROTEASE M1 ZINC METALLOPROTEASE PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237 metabolic process#GO:0008152;proteolysis#GO:0006508;peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238;catabolic process#GO:0009056 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG181333|UniProtKB=T1FGW6 T1FGW6 20208065 PTHR12844:SF42 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KSR PROTEIN CNK protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein complex scaffold activity#GO:0140378;MAP kinase scaffold activity#GO:0005078;signaling adaptor activity#GO:0035591;structural molecule activity#GO:0005198 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181398|UniProtKB=T1FGY8 T1FGY8 20208087 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG145646|UniProtKB=T1EJL6 T1EJL6 20196766 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69247|UniProtKB=T1FZR8 T1FZR8 20214316 PTHR13193:SF0 CGI-140 PAT COMPLEX SUBUNIT ASTERIX cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG179349|UniProtKB=T1FEL1 T1FEL1 20207260 PTHR22906:SF21 PROPERDIN ADHESION G PROTEIN-COUPLED RECEPTOR B1-LIKE HELRO|EnsemblGenome=HelroG178863|UniProtKB=T1FDU0 T1FDU0 20206989 PTHR15857:SF0 COMM DOMAIN CONTAINING PROTEIN 2 COMM DOMAIN-CONTAINING PROTEIN 2 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG83363|UniProtKB=T1G546 T1G546 20216194 PTHR46090:SF5 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;protein localization to cell periphery#GO:1990778;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512;organelle assembly#GO:0070925;localization within membrane#GO:0051668;cellular localization#GO:0051641;non-motile cilium assembly#GO:1905515;localization#GO:0051179;cilium organization#GO:0044782 cilium#GO:0005929;non-motile cilium#GO:0097730;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;cell projection membrane#GO:0031253;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG109714|UniProtKB=T1EEV9 T1EEV9 20195111 PTHR22847:SF637 WD40 REPEAT PROTEIN WD40 REPEAT-CONTAINING PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG179953|UniProtKB=T1FFA2 T1FFA2 20207501 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78376|UniProtKB=T1G3B2 T1G3B2 20215560 PTHR24416:SF634 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F binding#GO:0005488;collagen binding#GO:0005518;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199 cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of signaling#GO:0023056;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cell communication#GO:0010646;signaling#GO:0023052 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG114519|UniProtKB=T1EG23 T1EG23 20195525 PTHR12455:SF0 NUCLEOLAR COMPLEX PROTEIN 4 NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;90S preribosome#GO:0030686;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190368|UniProtKB=T1FRX7 T1FRX7 20211574 PTHR23510:SF16 INNER MEMBRANE TRANSPORT PROTEIN YAJR MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG156361|UniProtKB=T1ELU1 T1ELU1 20197541 PTHR11761:SF8 50S/60S RIBOSOMAL PROTEIN L14/L23 LARGE RIBOSOMAL SUBUNIT PROTEIN UL14 binding#GO:0005488;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185773|UniProtKB=T1FN98 T1FN98 20210296 PTHR11540:SF76 MALATE AND LACTATE DEHYDROGENASE MALATE DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;cellular process#GO:0009987;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG143239|UniProtKB=T1EJ95 T1EJ95 20196645 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191728|UniProtKB=T1FT85 T1FT85 20212032 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;channel activity#GO:0015267;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488 transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;homeostatic process#GO:0042592;metal ion transport#GO:0030001 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG115315|UniProtKB=T1EG75 T1EG75 20195577 PTHR14102:SF11 PAR-6-RELATED LD29223P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 establishment or maintenance of cell polarity#GO:0007163;cell-cell junction organization#GO:0045216;cell-cell junction maintenance#GO:0045217;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cell cycle process#GO:0022402;cellular process#GO:0009987;centrosome cycle#GO:0007098;cell junction organization#GO:0034330;cytoskeleton organization#GO:0007010 serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell cortex#GO:0005938;cell periphery#GO:0071944 tight junction#PC00214;cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG182965|UniProtKB=T1FJ01 T1FJ01 20208800 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG71648|UniProtKB=T1G0P8 T1G0P8 20214646 PTHR14614:SF170 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162676|UniProtKB=T1ET02 T1ET02 20199702 PTHR28532:SF1 GEO13458P1 LTO1 MATURATION FACTOR OF ABCE1 HELRO|EnsemblGenome=HelroG188581|UniProtKB=T1FQ54 T1FQ54 20210951 PTHR16196:SF0 CELL CYCLE CONTROL PROTEIN CWF25 PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 HELRO|EnsemblGenome=HelroG194468|UniProtKB=T1FW32 T1FW32 20213028 PTHR11814:SF272 SULFATE TRANSPORTER SOLUTE CARRIER FAMILY 26 MEMBER 10P-RELATED monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;bicarbonate transmembrane transporter activity#GO:0015106;chloride transmembrane transporter activity#GO:0015108;dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic ion transmembrane transporter activity#GO:0015075;carboxylic acid transmembrane transporter activity#GO:0046943 monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG179938|UniProtKB=T1FF97 T1FF97 20207496 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG123209|UniProtKB=T1EGX3 T1EGX3 20195823 PTHR11003:SF359 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG178772|UniProtKB=T1FDQ1 T1FDQ1 20206950 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG160213|UniProtKB=T1EPZ6 T1EPZ6 20198646 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG65174|UniProtKB=T1FY42 T1FY42 20213740 PTHR13318:SF190 PARTNER OF PAIRED, ISOFORM B-RELATED PARTNER OF PAIRED, ISOFORM B modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG192312|UniProtKB=T1FTT6 T1FTT6 20212233 PTHR43620:SF7 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD6-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG85834|UniProtKB=T1G631 T1G631 20216528 PTHR31449:SF3 UPF0598 PROTEIN C8ORF82 UPF0598 PROTEIN C8ORF82 HELRO|EnsemblGenome=HelroG178838|UniProtKB=T1FDT4 T1FDT4 20206983 PTHR10003:SF71 SUPEROXIDE DISMUTASE CU-ZN -RELATED EXTRACELLULAR SUPEROXIDE DISMUTASE [CU-ZN]-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;copper ion binding#GO:0005507;antioxidant activity#GO:0016209 superoxide metabolic process#GO:0006801;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;response to reactive oxygen species#GO:0000302;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;detoxification#GO:0098754;cellular response to toxic substance#GO:0097237;response to stress#GO:0006950;cellular oxidant detoxification#GO:0098869;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;cellular response to stimulus#GO:0051716 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG96238|UniProtKB=T1G9A9 T1G9A9 20217656 PTHR10218:SF360 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG G protein-coupled receptor binding#GO:0001664;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;protein binding#GO:0005515;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;intracellular signal transduction#GO:0035556 extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;cluster of actin-based cell projections#GO:0098862;cytoplasmic side of plasma membrane#GO:0009898;apical plasma membrane#GO:0016324;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic side of membrane#GO:0098562;apical part of cell#GO:0045177;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;brush border#GO:0005903;cell periphery#GO:0071944;protein-containing complex#GO:0032991;brush border membrane#GO:0031526;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG181083|UniProtKB=T1FGL6 T1FGL6 20207965 PTHR21493:SF254 CGI-141-RELATED/LIPASE CONTAINING PROTEIN GOLGI TRANSPORT PROTEIN 1-RELATED membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG175459|UniProtKB=T1F9A2 T1F9A2 20205401 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG108932|UniProtKB=T1EEP0 T1EEP0 20195042 PTHR45983:SF2 TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED PROTEIN-TYROSINE-PHOSPHATASE phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG170208|UniProtKB=T1F2S7 T1F2S7 20203126 PTHR14952:SF9 ROPPORIN-1-LIKE PROTEIN ROPPORIN-1-LIKE PROTEIN cell differentiation#GO:0030154;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;sperm motility#GO:0097722;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid development#GO:0007286;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;cell maturation#GO:0048469;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283 cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180520|UniProtKB=T1FG02 T1FG02 20207751 PTHR15712:SF23 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT CONTAINING 10 transport#GO:0006810;intracellular transport#GO:0046907;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;axo-dendritic transport#GO:0008088;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;axonal transport#GO:0098930;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158627|UniProtKB=T1EN13 T1EN13 20197963 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG166087|UniProtKB=T1EXQ7 T1EXQ7 20201357 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG154526|UniProtKB=T1ELE9 T1ELE9 20197399 PTHR10485:SF0 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17 AT05822P-RELATED transmembrane protein transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;mitochondrial transmembrane transport#GO:1990542;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG108276|UniProtKB=T1EEH9 T1EEH9 20194981 PTHR11208:SF42 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of cellular process#GO:0050794;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG185494|UniProtKB=T1FMW1 T1FMW1 20210160 PTHR11921:SF47 SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL electron transport chain#GO:0022900;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG194066|UniProtKB=T1FVM9 T1FVM9 20212875 PTHR46825:SF15 D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH BETA-LACTAMASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193312|UniProtKB=T1FUV3 T1FUV3 20212599 PTHR13314:SF2 CALCIUM CHANNEL FLOWER HOMOLOG CALCIUM CHANNEL FLOWER HOMOLOG monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085;calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 endocytosis#GO:0006897;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;synaptic vesicle endocytosis#GO:0048488;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;calcium ion transport#GO:0006816;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;endosome#GO:0005768;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG187814|UniProtKB=T1FPE3 T1FPE3 20210690 PTHR11384:SF62 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monocarboxylic acid transmembrane transporter activity#GO:0008028;nucleotide binding#GO:0000166;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265 primary metabolic process#GO:0044238;carboxylic acid transmembrane transport#GO:1905039;catabolic process#GO:0009056;monocarboxylic acid transport#GO:0015718;peroxisomal transport#GO:0043574;localization#GO:0051179;fatty acid transport#GO:0015908;lipid oxidation#GO:0034440;carboxylic acid catabolic process#GO:0046395;macromolecule localization#GO:0033036;lipid transport#GO:0006869;monocarboxylic acid catabolic process#GO:0072329;fatty acid beta-oxidation#GO:0006635;transport#GO:0006810;lipid metabolic process#GO:0006629;intracellular transport#GO:0046907;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;establishment of localization#GO:0051234;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;cellular component organization#GO:0016043;very long-chain fatty acid metabolic process#GO:0000038;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;peroxisome organization#GO:0007031;oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;fatty acid catabolic process#GO:0009062;transmembrane transport#GO:0055085;cellular localization#GO:0051641;lipid catabolic process#GO:0016042;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;fatty acid oxidation#GO:0019395;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840 microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG84698|UniProtKB=T1G5M4 T1G5M4 20216371 PTHR36911:SF1 LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66137|UniProtKB=T1FYH4 T1FYH4 20213872 PTHR16064:SF3 BTB POZ DOMAIN CONTAINING 7 BTB_POZ DOMAIN-CONTAINING PROTEIN 7 HELRO|EnsemblGenome=HelroG160109|UniProtKB=T1EPT2 T1EPT2 20198582 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186803|UniProtKB=T1FP38 T1FP38 20210585 PTHR15592:SF14 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG94509|UniProtKB=T1G914 T1G914 20217561 PTHR42735:SF1 FAMILY NOT NAMED PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED aldehyde-lyase activity#GO:0016832;lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 catabolic process#GO:0009056;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG162919|UniProtKB=T1ETC9 T1ETC9 20199829 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG179442|UniProtKB=T1FEQ1 T1FEQ1 20207300 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179855|UniProtKB=T1FF76 T1FF76 20207475 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185280|UniProtKB=T1FML7 T1FML7 20210066 PTHR12732:SF0 UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING PCI DOMAIN-CONTAINING PROTEIN 2 DNA binding#GO:0003677;RNA binding#GO:0003723;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;chromosome organization#GO:0051276;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transcription by RNA polymerase II#GO:0006366;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;RNA biosynthetic process#GO:0032774;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;localization#GO:0051179;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;organelle organization#GO:0006996;DNA-templated transcription elongation#GO:0006354;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization#GO:0016043;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transcription export complex 2#GO:0070390;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG65686|UniProtKB=T1FYB4 T1FYB4 20213812 PTHR11599:SF44 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA-RELATED catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;proteasome complex#GO:0000502;cytosol#GO:0005829;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG165701|UniProtKB=T1EX68 T1EX68 20201168 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG108067|UniProtKB=T1EEF0 T1EEF0 20194952 PTHR12700:SF12 ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL ATP SYNTHASE PERIPHERAL STALK SUBUNIT D, MITOCHONDRIAL proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;proton channel activity#GO:0015252;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803 purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;organophosphate biosynthetic process#GO:0090407;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ATP biosynthetic process#GO:0006754;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201 intracellular membrane-bounded organelle#GO:0043231;proton-transporting ATP synthase complex#GO:0045259;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;organelle membrane#GO:0031090;transporter complex#GO:1990351;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG181067|UniProtKB=T1FGK6 T1FGK6 20207955 PTHR12424:SF8 TWEETY-RELATED PROTEIN TWEETY HOMOLOG 1 gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG82746|UniProtKB=T1G4W0 T1G4W0 20216108 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG177906|UniProtKB=T1FCG3 T1FCG3 20206512 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178696|UniProtKB=T1FDL0 T1FDL0 20206909 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177705|UniProtKB=T1FC41 T1FC41 20206390 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG156791|UniProtKB=T1EM11 T1EM11 20197611 PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032;CCKR signaling map#P06959>MEF2D#P07048 HELRO|EnsemblGenome=HelroG171272|UniProtKB=T1F405 T1F405 20203554 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169375|UniProtKB=T1F1V4 T1F1V4 20202804 PTHR24410:SF47 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG123455|UniProtKB=T1EGX9 T1EGX9 20195829 PTHR46320:SF1 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;cellular process#GO:0009987;amine metabolic process#GO:0009308;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phospholipid metabolic process#GO:0006644;small molecule metabolic process#GO:0044281 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG70422|UniProtKB=T1G064 T1G064 20214462 PTHR19960:SF25 TEKTIN TEKTIN-1 cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG160409|UniProtKB=T1EQ78 T1EQ78 20198728 PTHR37162:SF15 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115778|UniProtKB=T1EGA4 T1EGA4 20195606 PTHR22836:SF0 WD40 REPEAT PROTEIN PRE-MRNA 3' END PROCESSING PROTEIN WDR33 intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG163464|UniProtKB=T1EU32 T1EU32 20200082 PTHR12373:SF0 ENHANCER OF RUDIMENTARY ERH ENHANCER OF RUDIMENTARY HOMOLOG molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of chromatin organization#GO:1902275;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nuclear mRNA surveillance#GO:0071028;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185285|UniProtKB=T1FML9 T1FML9 20210068 PTHR43157:SF74 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED DEHYDROGENASES, SHORT CHAIN-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG170089|UniProtKB=T1F2M0 T1F2M0 20203069 PTHR12233:SF1 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26 cytosolic transport#GO:0016482;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;retromer complex#GO:0030904;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG94672|UniProtKB=T1G922 T1G922 20217569 PTHR45629:SF16 SNF2/RAD54 FAMILY MEMBER DNA REPAIR AND RECOMBINATION PROTEIN RAD54B ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;DNA translocase activity#GO:0015616;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA recombination#GO:0006310;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;organelle fission#GO:0048285;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;homologous recombination#GO:0035825;reproductive process#GO:0022414;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG187046|UniProtKB=T1FP61 T1FP61 20210608 PTHR43127:SF1 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 1 guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185776|UniProtKB=T1FNA0 T1FNA0 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cellular localization#GO:0051641;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;organelle localization#GO:0051640;localization within membrane#GO:0051668;localization#GO:0051179;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;transport#GO:0006810;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;nucleus organization#GO:0006997;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;intracellular protein localization#GO:0008104;protein localization to nucleus#GO:0034504;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605;chromatin organization#GO:0006325;biological regulation#GO:0065007;membrane organization#GO:0061024;negative regulation of biosynthetic process#GO:0009890 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG165747|UniProtKB=T1EX87 T1EX87 20201187 PTHR12842:SF6 FI01459P FI01459P HELRO|EnsemblGenome=HelroG168488|UniProtKB=T1F0M6 T1F0M6 20202376 PTHR33844:SF1 SULFOTRANSFER_1 DOMAIN-CONTAINING PROTEIN SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106700|UniProtKB=T1EE38 T1EE38 20194840 PTHR13030:SF15 NUDIX HYDROLASE NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106726|UniProtKB=T1EE43 T1EE43 20194845 PTHR43580:SF10 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;DNA binding#GO:0003677 gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG186407|UniProtKB=T1FNZ3 T1FNZ3 20210540 PTHR24055:SF615 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;FGF signaling pathway#P00021>p38#P00644;TGF-beta signaling pathway#P00052>P38#P01275;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>p38#P00562;Ras Pathway#P04393>p38#P04558;Oxidative stress response#P00046>p38#P01135;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Parkinson disease#P00049>p38 MAPK#P01212 HELRO|EnsemblGenome=HelroG188284|UniProtKB=T1FPT9 T1FPT9 20210836 PTHR22872:SF9 BTK-BINDING PROTEIN-RELATED X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR HELRO|EnsemblGenome=HelroG185420|UniProtKB=T1FMS9 T1FMS9 20210128 PTHR24068:SF153 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 W aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG157132|UniProtKB=T1EM69 T1EM69 20197669 PTHR23147:SF133 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 10 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;membraneless organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nuclear body#GO:0016604;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG94411|UniProtKB=T1G909 T1G909 20217556 PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG177589|UniProtKB=T1FBW8 T1FBW8 20206317 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116717|UniProtKB=T1EGH1 T1EGH1 20195673 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857 potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG191270|UniProtKB=T1FST6 T1FST6 20211883 PTHR12549:SF11 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN LYSINE-SPECIFIC DEMETHYLASE 3 transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;chromatin DNA binding#GO:0031490;protein demethylase activity#GO:0140457;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;DNA binding#GO:0003677;histone modifying activity#GO:0140993 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG64136|UniProtKB=T1FXQ0 T1FXQ0 20213598 PTHR11711:SF481 ADP RIBOSYLATION FACTOR-RELATED ADP RIBOSYLATION FACTOR 4 guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein transport#GO:0015031;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG188913|UniProtKB=T1FQH1 T1FQH1 20211068 PTHR12747:SF0 ELONGATOR COMPLEX PROTEIN 1 ELONGATOR COMPLEX PROTEIN 1 RNA binding#GO:0003723;tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;binding#GO:0005488 tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;elongator holoenzyme complex#GO:0033588;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 general transcription factor#PC00259 PDGF signaling pathway#P00047>Ikk#P01146 HELRO|EnsemblGenome=HelroG185513|UniProtKB=T1FMX1 T1FMX1 20210170 PTHR10075:SF83 BASIGIN RELATED CONTACTIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG63833|UniProtKB=T1FXL1 T1FXL1 20213559 PTHR24343:SF345 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG177449|UniProtKB=T1FBQ4 T1FBQ4 20206253 PTHR47055:SF4 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT DERIVED 2 nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG62327|UniProtKB=T1FWZ5 T1FWZ5 20213343 PTHR45961:SF6 IP21249P IP21249P hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG180242|UniProtKB=T1FFM0 T1FFM0 20207619 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG89417|UniProtKB=T1G7C8 T1G7C8 20216975 PTHR43398:SF1 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG76126|UniProtKB=T1G2F3 T1G2F3 20215251 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG171574|UniProtKB=T1F4E9 T1F4E9 20203698 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION HDC11342-RELATED regulation of mitotic spindle organization#GO:0060236;regulation of spindle assembly#GO:0090169;regulation of microtubule-based process#GO:0032886;regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of spindle organization#GO:0090224;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of mitotic spindle assembly#GO:1901673;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of mitotic cell cycle#GO:0007346;regulation of organelle assembly#GO:1902115 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG180041|UniProtKB=T1FFD8 T1FFD8 20207537 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG160928|UniProtKB=T1EQV4 T1EQV4 20198954 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG174886|UniProtKB=T1F8K7 T1F8K7 20205156 PTHR12707:SF0 PINN PININ catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG189197|UniProtKB=T1FQS0 T1FQS0 20211167 PTHR11516:SF60 PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;aerobic respiration#GO:0009060;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;acetyl-CoA metabolic process#GO:0006084;small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex#GO:1990234;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;mitochondrial matrix#GO:0005759;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 Pyruvate metabolism#P02772>Pyruvate Dehydrogenase#P03133 HELRO|EnsemblGenome=HelroG77327|UniProtKB=T1G2W2 T1G2W2 20215410 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG70454|UniProtKB=T1G066 T1G066 20214464 PTHR15858:SF7 IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1 IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1 regulation of biological process#GO:0050789;regulation of protein secretion#GO:0050708;regulation of cellular component organization#GO:0051128;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;positive regulation of secretion#GO:0051047;positive regulation of cellular component organization#GO:0051130;regulation of establishment of protein localization#GO:0070201;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;regulation of protein localization#GO:0032880;regulation of secretion by cell#GO:1903530;localization#GO:0051179;regulation of secretion#GO:0051046;cellular localization#GO:0051641;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of protein secretion#GO:0050714;establishment of localization#GO:0051234 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HELRO|EnsemblGenome=HelroG190600|UniProtKB=T1FS44 T1FS44 20211641 PTHR13634:SF0 RIBOSOME BIOGENESIS PROTEIN BRIX RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;ribosomal large subunit assembly#GO:0000027;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160147|UniProtKB=T1EPV9 T1EPV9 20209551 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG167331|UniProtKB=T1EZ97 T1EZ97 20201897 PTHR15217:SF0 WILMS' TUMOR 1-ASSOCIATING PROTEIN PRE-MRNA-SPLICING REGULATOR WTAP molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;regulation of mRNA metabolic process#GO:1903311;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;methyltransferase complex#GO:0034708;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG175840|UniProtKB=T1F9R2 T1F9R2 20205561 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;DNA exonuclease activity#GO:0004529;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;exonuclease activity#GO:0004527;endonuclease activity#GO:0004519;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG185520|UniProtKB=T1FMX4 T1FMX4 20210173 PTHR10836:SF76 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED glyceraldehyde-3-phosphate dehydrogenase (phosphorylating, [NAD(P)+] ) activity#GO:0043891;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496;ADP catabolic process#GO:0046032;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 Huntington disease#P00029>GAPDH#P00810;Glycolysis#P00024>Glyceraldehyde 3-phosphate dehydrogenase#P00676 HELRO|EnsemblGenome=HelroG77797|UniProtKB=T1G342 T1G342 20215490 PTHR22923:SF120 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159493|UniProtKB=T1EP35 T1EP35 20198335 PTHR31802:SF53 32 KDA HEAT SHOCK PROTEIN-RELATED SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG147884|UniProtKB=T1EK33 T1EK33 20196934 PTHR23430:SF50 HISTONE H2A HISTONE H2A structural molecule activity#GO:0005198 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191943|UniProtKB=T1FTF6 T1FTF6 20212103 PTHR19321:SF57 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle elongation#GO:0051231;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;organelle assembly#GO:0070925;nuclear division#GO:0000280 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG181744|UniProtKB=T1FH99 T1FH99 20208198 PTHR12902:SF39 WASP-1 WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER protein-containing complex binding#GO:0044877;protein binding#GO:0005515;protein kinase A regulatory subunit binding#GO:0034237;binding#GO:0005488;protein kinase A binding#GO:0051018 actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of organelle organization#GO:0010638;actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG178958|UniProtKB=T1FDY8 T1FDY8 20207037 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194101|UniProtKB=T1FVN9 T1FVN9 20212885 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG167941|UniProtKB=T1EZZ7 T1EZZ7 20202147 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177346|UniProtKB=T1FBJ4 T1FBJ4 20206193 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of neurogenesis#GO:0050767;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;anterior/posterior pattern specification#GO:0009952;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG192727|UniProtKB=T1FU85 T1FU85 20212381 PTHR18898:SF8 NUCLEOPROTEIN TPR-RELATED NUCLEOPROTEIN TPR structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 regulation of microtubule cytoskeleton organization#GO:0070507;regulation of cell cycle process#GO:0010564;gene expression#GO:0010467;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;regulation of mitotic spindle assembly#GO:1901673;metabolic process#GO:0008152;regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of spindle assembly#GO:0090169;regulation of mitotic spindle organization#GO:0060236;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;regulation of organelle assembly#GO:1902115;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA transport#GO:0050658;RNA localization#GO:0006403;regulation of cellular process#GO:0050794;nucleobase-containing compound transport#GO:0015931;regulation of cytoskeleton organization#GO:0051493;regulation of spindle organization#GO:0090224;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;regulation of microtubule-based process#GO:0032886 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG141556|UniProtKB=T1EJ36 T1EJ36 20196586 PTHR19297:SF192 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3-RELATED glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG183270|UniProtKB=T1FJE2 T1FJE2 20208941 PTHR16019:SF5 SYNAPSE-ASSOCIATED PROTEIN BSD DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG164909|UniProtKB=T1EVY6 T1EVY6 20200736 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165592|UniProtKB=T1EX18 T1EX18 20201118 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187042|UniProtKB=T1FP60 T1FP60 20210607 PTHR11629:SF114 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A binding#GO:0005488;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;enzyme binding#GO:0019899;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;proton transmembrane transport#GO:1902600;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG63272|UniProtKB=T1FXD4 T1FXD4 20213482 PTHR23074:SF78 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2 ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657 microtubule cytoskeleton organization#GO:0000226;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;meiotic cell cycle#GO:0051321;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;organelle organization#GO:0006996;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG160282|UniProtKB=T1EQ17 T1EQ17 20198667 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG158882|UniProtKB=T1END2 T1END2 20198082 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76483|UniProtKB=T1G2K4 T1G2K4 20215302 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG190469|UniProtKB=T1FS04 T1FS04 20211601 PTHR11731:SF202 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG78299|UniProtKB=T1G3A6 T1G3A6 20215554 PTHR23405:SF5 MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED THO COMPLEX SUBUNIT 7 establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;transcription export complex#GO:0000346;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG189072|UniProtKB=T1FQM2 T1FQM2 20211119 PTHR45924:SF2 FI17866P1 FI17866P1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme binding#GO:0019899;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267 HELRO|EnsemblGenome=HelroG165620|UniProtKB=T1EX32 T1EX32 20201132 PTHR24406:SF23 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG107533|UniProtKB=T1EEB0 T1EEB0 20194912 PTHR11153:SF14 SIDEROFLEXIN SIDEROFLEXIN-2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;amino acid transmembrane transport#GO:0003333;cellular localization#GO:0051641;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;mitochondrial transmembrane transport#GO:1990542;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039;establishment of localization#GO:0051234;intracellular transport#GO:0046907;organic acid transport#GO:0015849;amino acid transport#GO:0006865;transport#GO:0006810;carboxylic acid transport#GO:0046942;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG188623|UniProtKB=T1FQ69 T1FQ69 20210966 PTHR10121:SF0 COATOMER SUBUNIT DELTA COATOMER SUBUNIT DELTA protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 intracellular transport#GO:0046907;organelle localization#GO:0051640;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;vesicle-mediated transport#GO:0016192 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;COPI-coated vesicle#GO:0030137;membrane#GO:0016020;vesicle membrane#GO:0012506;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG65129|UniProtKB=T1FY35 T1FY35 20213733 PTHR16222:SF44 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 catalytic activity#GO:0003824;hydrolase activity#GO:0016787 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG174506|UniProtKB=T1F872 T1F872 20205021 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG166784|UniProtKB=T1EYI9 T1EYI9 20201639 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG180495|UniProtKB=T1FFZ5 T1FFZ5 20207744 PTHR46518:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 151 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3 cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cilium assembly#GO:0060271;axoneme assembly#GO:0035082;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;organelle assembly#GO:0070925;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG112087|UniProtKB=T1EFG9 T1EFG9 20195321 PTHR23389:SF6 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 REPLICATION FACTOR C SUBUNIT 1 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG104934|UniProtKB=T1EDP2 T1EDP2 20194694 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG94814|UniProtKB=T1G932 T1G932 20217579 PTHR11254:SF429 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SU(DX) transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67893|UniProtKB=T1FZ72 T1FZ72 20214120 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;positive regulation of cellular component organization#GO:0051130;actin filament-based process#GO:0030029;positive regulation of organelle organization#GO:0010638;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;positive regulation of actin filament bundle assembly#GO:0032233 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG192348|UniProtKB=T1FTU7 T1FTU7 20212244 PTHR33995:SF7 PROTEIN CBG18546 CPW-WPC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184200|UniProtKB=T1FKR2 T1FKR2 20209411 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG182195|UniProtKB=T1FHW7 T1FHW7 20208416 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75112|UniProtKB=T1G209 T1G209 20215107 PTHR12482:SF5 LIPASE ROG1-RELATED-RELATED DUF676 DOMAIN-CONTAINING PROTEIN lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG96929|UniProtKB=T1G9E4 T1G9E4 20217691 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A8-LIKE steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG185981|UniProtKB=T1FNI5 T1FNI5 20210382 PTHR19957:SF3 SYNTAXIN SYNTAXIN-5 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;cellular component organization#GO:0016043;vesicle fusion#GO:0006906 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 SNARE protein#PC00034 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091 HELRO|EnsemblGenome=HelroG173199|UniProtKB=T1F6J7 T1F6J7 20204446 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181426|UniProtKB=T1FH00 T1FH00 20208099 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG SPT20 HOMOLOG, SAGA COMPLEX COMPONENT-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;chromatin#GO:0000785;SAGA complex#GO:0000124;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG170489|UniProtKB=T1F344 T1F344 20203243 PTHR22742:SF2 EXPANSION, ISOFORM A-RELATED EXPANSION, ISOFORM A-RELATED HELRO|EnsemblGenome=HelroG184990|UniProtKB=T1FM86 T1FM86 20209935 PTHR10383:SF9 SERINE INCORPORATOR SERINE INCORPORATOR, ISOFORM F cellular anatomical structure#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG109739|UniProtKB=T1EEW2 T1EEW2 20195114 PTHR22811:SF14 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN LP01981P-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;Golgi organization#GO:0007030;cellular component organization#GO:0016043 endomembrane system#GO:0012505;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG184900|UniProtKB=T1FM52 T1FM52 20209901 PTHR11902:SF1 ENOLASE ENOLASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;phosphopyruvate hydratase activity#GO:0004634 ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG178771|UniProtKB=T1FDQ0 T1FDQ0 20206949 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG107437|UniProtKB=T1EEA6 T1EEA6 20194908 PTHR23083:SF476 TETRATRICOPEPTIDE REPEAT PROTEIN, TPR TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A localization within membrane#GO:0051668;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;cellular localization#GO:0051641;localization#GO:0051179;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;protein localization to cell periphery#GO:1990778;metabolic process#GO:0008152;intracellular protein localization#GO:0008104;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule localization#GO:0033036;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG68977|UniProtKB=T1FZM9 T1FZM9 20214277 PTHR46473:SF30 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN molecular function activator activity#GO:0140677;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;voltage-gated channel activity#GO:0022832;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel regulator activity#GO:0016247;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter binding#GO:0044325;potassium channel activity#GO:0005267;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ion channel regulator activity#GO:0099106 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG71728|UniProtKB=T1G0Q5 T1G0Q5 20214653 PTHR19248:SF32 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY E MEMBER 1 purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;iron ion binding#GO:0005506;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;metal ion binding#GO:0046872;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;binding#GO:0005488;nucleotide binding#GO:0000166;ribonucleoprotein complex binding#GO:0043021;cation binding#GO:0043169;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914 gene expression#GO:0010467;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;protein-containing complex disassembly#GO:0032984;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;translational termination#GO:0006415;translation#GO:0006412;translational initiation#GO:0006413 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG183941|UniProtKB=T1FKB9 T1FKB9 20209268 PTHR13527:SF0 SAYSVFN DOMAIN-CONTAINING PROTEIN 1 SAYSVFN DOMAIN-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein biosynthetic process#GO:0160307;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;rescue of stalled cytosolic ribosome#GO:0072344;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;translation#GO:0006412;protein catabolic process#GO:0030163;gene expression#GO:0010467;biosynthetic process#GO:0009058;organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;translational elongation#GO:0006414 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG96355|UniProtKB=T1G9B6 T1G9B6 20217663 PTHR42884:SF13 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 2 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 biosynthetic process#GO:0009058;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;gene expression#GO:0010467;protein maturation#GO:0051604;peptide hormone processing#GO:0016486;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;proteolysis#GO:0006508 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG187499|UniProtKB=T1FPA2 T1FPA2 20210649 PTHR11699:SF302 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 aldehyde catabolic process#GO:0046185;catabolic process#GO:0009056;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG193550|UniProtKB=T1FV42 T1FV42 20212688 PTHR10807:SF110 MYOTUBULARIN-RELATED FI17948P1 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG74190|UniProtKB=T1G1N5 T1G1N5 20214983 PTHR46810:SF1 INACTIVE POLYGLYCYLASE TTLL10 INACTIVE POLYGLYCYLASE TTLL10 catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 HELRO|EnsemblGenome=HelroG70474|UniProtKB=T1G069 T1G069 20214467 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;positive regulation of MAPK cascade#GO:0043410;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174320|UniProtKB=T1F7Z9 T1F7Z9 20204948 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|Gene=LOX2|UniProtKB=Q01622 Q01622 LOX2 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HB1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG112230|UniProtKB=T1EFI0 T1EFI0 20195332 PTHR12789:SF0 DENSITY-REGULATED PROTEIN HOMOLOG DENSITY-REGULATED PROTEIN protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG167992|UniProtKB=T1F018 T1F018 20202168 PTHR16451:SF7 MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN positive regulation of organelle organization#GO:0010638;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of developmental process#GO:0051094;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of mitochondrial fission#GO:0090140;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;positive regulation of mitochondrial fission#GO:0090141;regulation of organelle organization#GO:0033043;regulation of mitochondrion organization#GO:0010821;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789 mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG114451|UniProtKB=T1EG19 T1EG19 20195521 PTHR12428:SF66 OXA1 MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977;molecular carrier activity#GO:0140104 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrial membrane organization#GO:0007006;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 transporter#PC00227 HELRO|EnsemblGenome=HelroG75171|UniProtKB=T1G220 T1G220 20215118 PTHR11937:SF13 ACTIN ACTIN-RELATED PROTEIN 8 RNA binding#GO:0003723;structural molecule activity#GO:0005198;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488 DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to stress#GO:0033554;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;Ino80 complex#GO:0031011 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG69024|UniProtKB=T1FZN6 T1FZN6 20214284 PTHR16089:SF28 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG101473|UniProtKB=T1ED49 T1ED49 20194501 PTHR19876:SF1 COATOMER COATOMER SUBUNIT ALPHA vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 vesicle coat#GO:0030120;cytoplasm#GO:0005737;COPI-coated vesicle#GO:0030137;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;COPI vesicle coat#GO:0030126;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular organelle#GO:0043229 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG186157|UniProtKB=T1FNQ9 T1FNQ9 20210456 PTHR10177:SF629 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B3 protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle G1/S phase transition#GO:0044843 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG191009|UniProtKB=T1FSH8 T1FSH8 20211775 PTHR11787:SF4 RAB GDP-DISSOCIATION INHIBITOR CHM, RAB ESCORT PROTEIN 1 protein targeting#GO:0006605;vesicle-mediated transport#GO:0016192;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein targeting to membrane#GO:0006612;transport#GO:0006810;localization within membrane#GO:0051668 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG85898|UniProtKB=T1G640 T1G640 20216537 PTHR11434:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG166276|UniProtKB=T1EXY9 T1EXY9 20201439 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168974|UniProtKB=T1F175 T1F175 20202575 PTHR24200:SF11 TOUCAN, ISOFORM A TOUCAN, ISOFORM A HELRO|EnsemblGenome=HelroG194936|UniProtKB=T1FWL2 T1FWL2 20213207 PTHR21538:SF23 ANILLIN/RHOTEKIN RTKN ANILLIN septin cytoskeleton organization#GO:0032185;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;actomyosin contractile ring assembly#GO:0000915;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;septin ring organization#GO:0031106;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640;cell division#GO:0051301;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cell cycle#GO:0007049;actomyosin structure organization#GO:0031032;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;contractile ring#GO:0070938;actomyosin contractile ring#GO:0005826 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG165700|UniProtKB=T1EX67 T1EX67 20201167 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183925|UniProtKB=T1FKB0 T1FKB0 20209259 PTHR21436:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 142 COILED-COIL DOMAIN-CONTAINING PROTEIN 142 HELRO|EnsemblGenome=HelroG74475|UniProtKB=T1G1R6 T1G1R6 20215014 PTHR22996:SF30 MAHOGUNIN RE60872P-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG193552|UniProtKB=T1FV44 T1FV44 20212690 PTHR21477:SF13 ZGC:172139 KIAA0930 HELRO|EnsemblGenome=HelroG165411|UniProtKB=T1EWQ9 T1EWQ9 20201009 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190578|UniProtKB=T1FS41 T1FS41 20211638 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG185877|UniProtKB=T1FNE0 T1FNE0 20210337 PTHR21106:SF2 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6 GM23292P catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG177959|UniProtKB=T1FCI7 T1FCI7 20206536 PTHR10174:SF166 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED LD40136P phosphatidylinositol bisphosphate binding#GO:1902936;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG190136|UniProtKB=T1FRQ2 T1FRQ2 20211499 PTHR11560:SF15 39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL10M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412 mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG184572|UniProtKB=T1FLI1 T1FLI1 20209680 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191173|UniProtKB=T1FSP6 T1FSP6 20211843 PTHR15036:SF88 PIKACHURIN-LIKE PROTEIN PIKACHURIN multicellular organism development#GO:0007275;developmental process#GO:0032502;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cell junction#GO:0030054;extracellular region#GO:0005576;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;basement membrane#GO:0005604;extracellular matrix#GO:0031012;membrane#GO:0016020;external encapsulating structure#GO:0030312 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG122144|UniProtKB=T1EGU2 T1EGU2 20195792 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG93645|UniProtKB=T1G8X1 T1G8X1 20217518 PTHR10984:SF30 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982 HELRO|EnsemblGenome=HelroG173929|UniProtKB=T1F7E0 T1F7E0 20204739 PTHR33395:SF24 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG124289|UniProtKB=T1EH07 T1EH07 20195857 PTHR24390:SF271 ZINC FINGER PROTEIN FI23536P1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG68987|UniProtKB=T1FZN1 T1FZN1 20214279 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N(6)-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT METTL3 catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA modification#GO:0016556 nucleus#GO:0005634;methyltransferase complex#GO:0034708;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG162666|UniProtKB=T1ESZ6 T1ESZ6 20199696 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG168602|UniProtKB=T1F0S4 T1F0S4 20202424 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG194254|UniProtKB=T1FVV4 T1FVV4 20212950 PTHR16484:SF17 PARTITIONING DEFECTIVE 3 RELATED BAZOOKA, ISOFORM B phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167 establishment of cell polarity#GO:0030010;cellular component organization#GO:0016043;establishment or maintenance of bipolar cell polarity#GO:0061245;cell adhesion#GO:0007155;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;microtubule cytoskeleton organization#GO:0000226;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;apical plasma membrane#GO:0016324;cell-cell junction#GO:0005911;membrane#GO:0016020;cell cortex#GO:0005938;cell periphery#GO:0071944;cell junction#GO:0030054;adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;apical junction complex#GO:0043296;apical part of cell#GO:0045177 HELRO|EnsemblGenome=HelroG189263|UniProtKB=T1FQW0 T1FQW0 20211207 PTHR12461:SF110 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED JMJC DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187823|UniProtKB=T1FPE6 T1FPE6 20210693 PTHR15829:SF13 PROTEIN KINASE PKN/PRK1, EFFECTOR FAM65 N-TERMINAL DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG177756|UniProtKB=T1FC73 T1FC73 20206422 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG167326|UniProtKB=T1EZ95 T1EZ95 20201895 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG116595|UniProtKB=T1EGG3 T1EGG3 20195665 PTHR12280:SF30 PANTOTHENATE KINASE PANTOTHENATE KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase#PC00137;metabolite interconversion enzyme#PC00262 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG64451|UniProtKB=T1FXV2 T1FXV2 20213650 PTHR15217:SF0 WILMS' TUMOR 1-ASSOCIATING PROTEIN PRE-MRNA-SPLICING REGULATOR WTAP enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of RNA metabolic process#GO:0051252;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of mRNA metabolic process#GO:1903311;mRNA processing#GO:0006397;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG113661|UniProtKB=T1EFU8 T1EFU8 20195450 PTHR22957:SF168 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG108605|UniProtKB=T1EEK8 T1EEK8 20195010 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG64397|UniProtKB=T1FXU2 T1FXU2 20213640 PTHR13140:SF781 MYOSIN MYOSIN-11 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;membrane#GO:0016020;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG67918|UniProtKB=T1FZ77 T1FZ77 20214125 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG cellular developmental process#GO:0048869;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cilium assembly#GO:0060271;cellular component organization#GO:0016043 cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729 HELRO|EnsemblGenome=HelroG161600|UniProtKB=T1ERP3 T1ERP3 20199243 PTHR10336:SF80 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN C2 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;signaling#GO:0023052;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;metabolic process#GO:0008152;monoatomic cation transmembrane transport#GO:0098655;glycerophospholipid metabolic process#GO:0006650;signal transduction#GO:0007165;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;intracellular signal transduction#GO:0035556;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;metal ion transport#GO:0030001;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;establishment of localization#GO:0051234;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;transport#GO:0006810;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;organophosphate metabolic process#GO:0019637 lipase#PC00143;metabolite interconversion enzyme#PC00262;phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193446|UniProtKB=T1FUZ8 T1FUZ8 20212644 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG169261|UniProtKB=T1F1N3 T1F1N3 20202733 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62217|UniProtKB=T1FWX1 T1FWX1 20213319 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177443|UniProtKB=T1FBP9 T1FBP9 20206248 PTHR35711:SF1 EXPRESSED PROTEIN ECTODERMAL, ISOFORM F HELRO|EnsemblGenome=HelroG145992|UniProtKB=T1EJP5 T1EJP5 20196795 PTHR21493:SF254 CGI-141-RELATED/LIPASE CONTAINING PROTEIN GOLGI TRANSPORT PROTEIN 1-RELATED organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175770|UniProtKB=T1F9M8 T1F9M8 20205527 PTHR18843:SF7 TORSIN-1A-INTERACTING PROTEIN SI:DKEYP-82A1.6 membrane organization#GO:0061024;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG85777|UniProtKB=T1G627 T1G627 20216524 PTHR21490:SF0 ENKURIN-RELATED ENKURIN calmodulin binding#GO:0005516;binding#GO:0005488;protein binding#GO:0005515 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;secretory vesicle#GO:0099503;microtubule cytoskeleton#GO:0015630;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;acrosomal vesicle#GO:0001669;cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;cytoplasmic microtubule#GO:0005881;intracellular vesicle#GO:0097708;vesicle#GO:0031982;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG164706|UniProtKB=T1EVR1 T1EVR1 20200661 PTHR45617:SF188 LEUCINE RICH REPEAT FAMILY PROTEIN ELRR (EXTRACELLULAR LEUCINE-RICH REPEAT) ONLY scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG116244|UniProtKB=T1EGD7 T1EGD7 20195639 PTHR45662:SF2 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG109536|UniProtKB=T1EEU6 T1EEU6 20195098 PTHR45653:SF13 DEDICATOR OF CYTOKINESIS MYOBLAST CITY, ISOFORM B enzyme binding#GO:0019899;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 cell differentiation#GO:0030154;cell migration#GO:0016477;cell motility#GO:0048870;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 Integrin signalling pathway#P00034>Dock180#P00930 HELRO|EnsemblGenome=HelroG191249|UniProtKB=T1FSS7 T1FSS7 20211874 PTHR46380:SF2 CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1 CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG185540|UniProtKB=T1FMY3 T1FMY3 20210182 PTHR43238:SF1 GDP-L-FUCOSE SYNTHASE GDP-L-FUCOSE SYNTHASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG66873|UniProtKB=T1FYS2 T1FYS2 20213970 PTHR15454:SF73 NISCHARIN RELATED DYNEIN AXONEMAL LIGHT CHAIN 1 binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194547|UniProtKB=T1FW66 T1FW66 20213062 PTHR46539:SF2 E3 UBIQUITIN-PROTEIN LIGASE ATL42 RING-H2 FINGER PROTEIN ATL43 catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG188105|UniProtKB=T1FPN1 T1FPN1 20210778 PTHR22765:SF463 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE HRD1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG193557|UniProtKB=T1FV47 T1FV47 20212693 PTHR11134:SF33 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP COMPLEX SUBUNIT BETA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 clathrin vesicle coat#GO:0030125;clathrin-coated vesicle membrane#GO:0030665;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;coated membrane#GO:0048475;coated vesicle#GO:0030135;intracellular vesicle#GO:0097708;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG167034|UniProtKB=T1EYX6 T1EYX6 20201776 PTHR24161:SF130 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194215|UniProtKB=T1FVT5 T1FVT5 20212931 PTHR13448:SF0 TRANSMEMBRANE PROTEIN 214 TRANSMEMBRANE PROTEIN 214 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG170221|UniProtKB=T1F2S9 T1F2S9 20203128 PTHR12810:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29 SMALL RIBOSOMAL SUBUNIT PROTEIN MS29 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG163461|UniProtKB=T1EU29 T1EU29 20200079 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194049|UniProtKB=T1FVM2 T1FVM2 20212868 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194885|UniProtKB=T1FWJ2 T1FWJ2 20213187 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185375|UniProtKB=T1FMQ7 T1FMQ7 20210106 PTHR11710:SF0 40S RIBOSOMAL PROTEIN S19 SMALL RIBOSOMAL SUBUNIT PROTEIN ES19 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG167717|UniProtKB=T1EZQ1 T1EZQ1 20202051 PTHR14167:SF125 SH3 DOMAIN-CONTAINING CAP, ISOFORM AC protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177626|UniProtKB=T1FBY4 T1FBY4 20206333 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;exopeptidase activity#GO:0008238;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG161971|UniProtKB=T1ES39 T1ES39 20199389 PTHR48209:SF2 AGL056WP FI24008P1 HELRO|EnsemblGenome=HelroG193827|UniProtKB=T1FVE4 T1FVE4 20212790 PTHR15749:SF4 FANCONI-ASSOCIATED NUCLEASE 1 FANCONI-ASSOCIATED NUCLEASE 1 HELRO|EnsemblGenome=HelroG157228|UniProtKB=T1EM86 T1EM86 20197686 PTHR11200:SF311 INOSITOL 5-PHOSPHATASE SYNAPTOJANIN-1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 synaptic vesicle endocytosis#GO:0048488;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;synaptic vesicle recycling#GO:0036465;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;cellular localization#GO:0051641;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase#PC00181;hydrolase#PC00121 Huntington disease#P00029>Synaptojanin#P00804 HELRO|EnsemblGenome=HelroG184982|UniProtKB=T1FM81 T1FM81 20209930 PTHR33539:SF1 UPF0764 PROTEIN C16ORF89 UPF0764 PROTEIN C16ORF89 membrane#GO:0016020;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG93221|UniProtKB=T1G8U5 T1G8U5 20217492 PTHR23188:SF12 RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;chromatin binding#GO:0003682;RNA polymerase binding#GO:0070063 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG79628|UniProtKB=T1G3R4 T1G3R4 20215712 PTHR10030:SF37 ALPHA-L-FUCOSIDASE TISSUE ALPHA-L-FUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;glycosyl compound catabolic process#GO:1901658;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185072|UniProtKB=T1FMD0 T1FMD0 20209979 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185345|UniProtKB=T1FMP7 T1FMP7 20210096 PTHR13164:SF3 CALICYLIN BINDING PROTEIN CALCYCLIN-BINDING PROTEIN protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899 multicellular organismal process#GO:0032501;circulatory system development#GO:0072359;heart development#GO:0007507;system development#GO:0048731;animal organ development#GO:0048513;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84047|UniProtKB=T1G5D9 T1G5D9 20216286 PTHR24089:SF769 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SCAMC transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 carbohydrate derivative transport#GO:1901264;transport#GO:0006810;nitrogen compound transport#GO:0071705;localization#GO:0051179;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;establishment of localization#GO:0051234 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HELRO|EnsemblGenome=HelroG77720|UniProtKB=T1G331 T1G331 20215479 PTHR11636:SF83 POU DOMAIN POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 4 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG181856|UniProtKB=T1FHE6 T1FHE6 20208245 PTHR10426:SF88 STRICTOSIDINE SYNTHASE-RELATED ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG185710|UniProtKB=T1FN65 T1FN65 20210263 PTHR10535:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;RNA polymerase I complex#GO:0005736;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG168935|UniProtKB=T1F157 T1F157 20202557 PTHR13802:SF52 MUCIN 4-RELATED NIDOGEN-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG166710|UniProtKB=T1EYE6 T1EYE6 20201596 PTHR11616:SF38 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT DOPAMINE TRANSPORTER establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;amino acid transport#GO:0006865;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>DAT#P00065;Parkinson disease#P00049>DAT#P01228;Dopamine receptor mediated signaling pathway#P05912>DAT#P05962;Parkinson disease#P00049>DAT#G01547 HELRO|EnsemblGenome=HelroG190996|UniProtKB=T1FSH5 T1FSH5 20211772 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of signaling#GO:0023056;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;ERBB signaling pathway#GO:0038127 signaling receptor complex#GO:0043235;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;basal part of cell#GO:0045178;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG173174|UniProtKB=T1F6I4 T1F6I4 20204433 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG164675|UniProtKB=T1EVP8 T1EVP8 20200648 PTHR15654:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 184 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG107104|UniProtKB=T1EE75 T1EE75 20194877 PTHR22781:SF14 DELTA ADAPTIN-RELATED AP-3 COMPLEX SUBUNIT DELTA-1 vesicle budding from membrane#GO:0006900;vesicle cytoskeletal trafficking#GO:0099518;anterograde synaptic vesicle transport#GO:0048490;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;vacuolar transport#GO:0007034;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;membrane organization#GO:0061024;cytoskeleton-dependent intracellular transport#GO:0030705;synaptic vesicle recycling#GO:0036465;vesicle localization#GO:0051648;synaptic vesicle membrane organization#GO:0048499;axo-dendritic transport#GO:0008088;macromolecule localization#GO:0033036;anterograde axonal transport#GO:0008089;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;organelle localization#GO:0051640;axonal transport#GO:0098930;endosome to lysosome transport#GO:0008333;protein localization to vacuole#GO:0072665;protein localization to organelle#GO:0033365;microtubule-based movement#GO:0007018;vesicle organization#GO:0016050;microtubule-based process#GO:0007017;endosomal transport#GO:0016197;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;endomembrane system organization#GO:0010256;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein targeting to vacuole#GO:0006623;synaptic vesicle transport#GO:0048489;organelle organization#GO:0006996;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;lysosomal transport#GO:0007041;protein targeting#GO:0006605;establishment of organelle localization#GO:0051656;establishment of protein localization to vacuole#GO:0072666;cellular component organization#GO:0016043;protein localization to lysosome#GO:0061462 axon#GO:0030424;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane coat#GO:0030117;vesicle#GO:0031982;membrane protein complex#GO:0098796;neuron projection terminus#GO:0044306;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;distal axon#GO:0150034;axon terminus#GO:0043679;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;coated membrane#GO:0048475;intracellular vesicle#GO:0097708;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991 transporter#PC00227 HELRO|EnsemblGenome=HelroG185575|UniProtKB=T1FMZ8 T1FMZ8 20210197 PTHR23420:SF0 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG180379|UniProtKB=T1FFU9 T1FFU9 20207698 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG155666|UniProtKB=T1ELK1 T1ELK1 20197451 PTHR24347:SF458 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789;regulation of protein localization#GO:0032880;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG75172|UniProtKB=T1G221 T1G221 20215119 PTHR45872:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;G protein-coupled receptor binding#GO:0001664;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;guanyl-nucleotide exchange factor activity#GO:0005085 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG69270|UniProtKB=T1FZS5 T1FZS5 20214323 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;bicarbonate transmembrane transporter activity#GO:0015106;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG75228|UniProtKB=T1G228 T1G228 20215126 PTHR11937:SF491 ACTIN PH DOMAIN-CONTAINING PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;structural constituent of cytoskeleton#GO:0005200;cytoskeletal adaptor activity#GO:0008093;protein-membrane adaptor activity#GO:0043495;structural molecule activity#GO:0005198 transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;nuclear migration#GO:0007097;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG150820|UniProtKB=T1EKH6 T1EKH6 20197076 PTHR24341:SF6 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN INVECTED nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG164645|UniProtKB=T1EVP0 T1EVP0 20200640 PTHR22761:SF10 CHARGED MULTIVESICULAR BODY PROTEIN BCDNA.GH08385-RELATED establishment of localization in cell#GO:0051649;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nuclear membrane organization#GO:0071763;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;nuclear envelope organization#GO:0006998;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;establishment of localization#GO:0051234;membrane assembly#GO:0071709;cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324;localization#GO:0051179;cellular localization#GO:0051641 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;cytoplasmic side of plasma membrane#GO:0009898;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic side of membrane#GO:0098562;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;plasma membrane#GO:0005886;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG115371|UniProtKB=T1EG77 T1EG77 20195579 PTHR11096:SF1 RNA 3' TERMINAL PHOSPHATE CYCLASE RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;cyclase activity#GO:0009975;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nuclease activity#GO:0004518 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193020|UniProtKB=T1FUJ0 T1FUJ0 20212486 PTHR22050:SF3 RW1 PROTEIN HOMOLOG TRANSMEMBRANE PROTEIN 131 HOMOLOG cellular process#GO:0009987;metabolic process#GO:0008152;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG191939|UniProtKB=T1FTF4 T1FTF4 20212101 PTHR15741:SF37 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR LD38259P transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG166292|UniProtKB=T1EXZ6 T1EXZ6 20201446 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG194640|UniProtKB=T1FW96 T1FW96 20213092 PTHR15688:SF1 KINETOCHORE-ASSOCIATED PROTEIN 1 KINETOCHORE-ASSOCIATED PROTEIN 1 protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme binding#GO:0019899;binding#GO:0005488 regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;negative regulation of mitotic nuclear division#GO:0045839;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;negative regulation of biological process#GO:0048519;sister chromatid segregation#GO:0000819;negative regulation of cell cycle phase transition#GO:1901988;nuclear chromosome segregation#GO:0098813;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;nuclear division#GO:0000280;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of chromosome segregation#GO:0051985;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;negative regulation of organelle organization#GO:0010639;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of mitotic sister chromatid segregation#GO:0033047;kinetochore organization#GO:0051383;protein localization to kinetochore#GO:0034501;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of cellular process#GO:0048523;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;negative regulation of mitotic sister chromatid separation#GO:2000816;kinetochore assembly#GO:0051382;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic spindle assembly checkpoint signaling#GO:0007094;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;cellular component assembly#GO:0022607;regulation of chromosome segregation#GO:0051983;chromosome segregation#GO:0007059;negative regulation of cell cycle#GO:0045786;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;organelle assembly#GO:0070925;negative regulation of chromosome organization#GO:2001251;intracellular signal transduction#GO:0035556;localization#GO:0051179;cell communication#GO:0007154;organelle fission#GO:0048285;regulation of mitotic cell cycle#GO:0007346;macromolecule localization#GO:0033036;mitotic sister chromatid segregation#GO:0000070;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;intracellular protein localization#GO:0008104;regulation of mitotic sister chromatid separation#GO:0010965 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;spindle#GO:0005819;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;kinetochore#GO:0000776 HELRO|EnsemblGenome=HelroG178975|UniProtKB=T1FDZ7 T1FDZ7 20207046 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65173|UniProtKB=T1FY41 T1FY41 20213739 PTHR45920:SF7 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN-G cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840 HELRO|EnsemblGenome=HelroG192710|UniProtKB=T1FU78 T1FU78 20212374 PTHR21082:SF4 PROTEIN INTURNED PROTEIN INTURNED organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cilium organization#GO:0044782;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG62307|UniProtKB=T1FWZ2 T1FWZ2 20213340 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG81006|UniProtKB=T1G481 T1G481 20215879 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG186263|UniProtKB=T1FNW0 T1FNW0 20210507 PTHR15451:SF19 ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG85916|UniProtKB=T1G643 T1G643 20216540 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER IP12869P carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG79776|UniProtKB=T1G3T1 T1G3T1 20215729 PTHR24637:SF437 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184367|UniProtKB=T1FL24 T1FL24 20209523 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185901|UniProtKB=T1FNF1 T1FNF1 20210348 PTHR11005:SF161 LYSOSOMAL ACID LIPASE-RELATED LIPASE catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid metabolic process#GO:0006629 hydrolase#PC00121;lipase#PC00143 HELRO|EnsemblGenome=HelroG174858|UniProtKB=T1F8J7 T1F8J7 20205146 PTHR42673:SF24 MALEYLACETOACETATE ISOMERASE MALEYLACETOACETATE ISOMERASE isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859;transferase activity#GO:0016740;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;glutathione metabolic process#GO:0006749;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 isomerase#PC00135 HELRO|EnsemblGenome=HelroG185178|UniProtKB=T1FMH2 T1FMH2 20210021 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG176625|UniProtKB=T1FAR0 T1FAR0 20205909 PTHR24115:SF344 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF28P microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092 establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle localization#GO:0051640 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG188646|UniProtKB=T1FQ78 T1FQ78 20210975 PTHR46961:SF13 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG170511|UniProtKB=T1F354 T1F354 20203253 PTHR13723:SF327 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PLAC DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG185909|UniProtKB=T1FNF6 T1FNF6 20210353 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 cellular process#GO:0009987;transport#GO:0006810;carbohydrate transport#GO:0008643;establishment of localization#GO:0051234;carbohydrate transmembrane transport#GO:0034219;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG167310|UniProtKB=T1EZ89 T1EZ89 20201889 PTHR21208:SF1 ADP-DEPENDENT GLUCOKINASE ADP-DEPENDENT GLUCOKINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 glucose metabolic process#GO:0006006;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 kinase#PC00137 HELRO|EnsemblGenome=HelroG112997|UniProtKB=T1EFP4 T1EFP4 20195396 PTHR21506:SF0 COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6 cellular component organization#GO:0016043;retrograde transport, vesicle recycling within Golgi#GO:0000301;organelle organization#GO:0006996;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;Golgi organization#GO:0007030;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;COG complex#GO:0017119;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155808|UniProtKB=T1ELM5 T1ELM5 20197475 PTHR12729:SF6 TRNA(HIS) GUANYLYLTRANSFERASE-RELATED TRNA(HIS) GUANYLYLTRANSFERASE-RELATED catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HELRO|EnsemblGenome=HelroG140431|UniProtKB=T1EJ07 T1EJ07 20196557 PTHR11685:SF427 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING RBR-TYPE E3 UBIQUITIN TRANSFERASE acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG172035|UniProtKB=T1F4Z0 T1F4Z0 20203889 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185351|UniProtKB=T1FMP9 T1FMP9 20210098 PTHR33562:SF2 ATILLA, ISOFORM B-RELATED-RELATED GEO05126P1 HELRO|EnsemblGenome=HelroG189016|UniProtKB=T1FQK4 T1FQK4 20211101 PTHR14270:SF0 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9 regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG157915|UniProtKB=T1EMH7 T1EMH7 20197777 PTHR26312:SF87 TETRATRICOPEPTIDE REPEAT PROTEIN 5 TETRATRICOPEPTIDE REPEAT PROTEIN 5 HELRO|EnsemblGenome=HelroG75686|UniProtKB=T1G290 T1G290 20215188 PTHR22974:SF23 MIXED LINEAGE PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular process#GO:0009987;cell cycle process#GO:0022402;chromosome segregation#GO:0007059;cell cycle#GO:0007049 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62422|UniProtKB=T1FX04 T1FX04 20213352 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG189986|UniProtKB=T1FRK2 T1FRK2 20211449 PTHR23291:SF127 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 1-LIKE monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;endoplasmic reticulum unfolded protein response#GO:0030968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;regulation of apoptotic signaling pathway#GO:2001233;cellular response to topologically incorrect protein#GO:0035967;negative regulation of apoptotic signaling pathway#GO:2001234;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;negative regulation of neuron apoptotic process#GO:0043524;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;negative regulation of signal transduction#GO:0009968;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;response to unfolded protein#GO:0006986;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG112766|UniProtKB=T1EFM0 T1EFM0 20195372 PTHR45630:SF23 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;polyamine transmembrane transporter activity#GO:0015203 intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;nitrogen compound transport#GO:0071705;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG177395|UniProtKB=T1FBM2 T1FBM2 20206221 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158017|UniProtKB=T1EMI7 T1EMI7 20197787 PTHR11937:SF47 ACTIN ACTIN-RELATED PROTEIN 6 chromatin binding#GO:0003682;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;protein-containing complex binding#GO:0044877;structural molecule activity#GO:0005198;nucleosome binding#GO:0031491 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;nucleolus organization#GO:0007000 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;Swr1 complex#GO:0000812;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG190569|UniProtKB=T1FS36 T1FS36 20211633 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG165989|UniProtKB=T1EXJ4 T1EXJ4 20201294 PTHR13371:SF0 GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN CENTROSOMAL PROTEIN OF 104 KDA cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG90419|UniProtKB=T1G7R2 T1G7R2 20217109 PTHR11538:SF40 PHENYLALANYL-TRNA SYNTHETASE PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152 catalytic complex#GO:1902494;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG186092|UniProtKB=T1FNN4 T1FNN4 20210431 PTHR11959:SF16 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG104401|UniProtKB=T1EDL4 T1EDL4 20194666 PTHR13105:SF24 MYELOID LEUKEMIA FACTOR MYELOID LEUKEMIA FACTOR regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG193843|UniProtKB=T1FVE9 T1FVE9 20212795 PTHR19960:SF25 TEKTIN TEKTIN-1 cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG91486|UniProtKB=T1G842 T1G842 20217239 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG106716|UniProtKB=T1EE41 T1EE41 20194843 PTHR47958:SF56 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX23-RELATED isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG169603|UniProtKB=T1F257 T1F257 20202907 PTHR18763:SF0 WD-REPEAT PROTEIN 18 WD REPEAT-CONTAINING PROTEIN 18 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;endonuclease complex#GO:1905348;protein-containing complex#GO:0032991;nucleus#GO:0005634;nuclear pre-replicative complex#GO:0005656;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoribonuclease complex#GO:1902555;pre-replicative complex#GO:0036387;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG165209|UniProtKB=T1EWF8 T1EWF8 20200908 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159582|UniProtKB=T1EP70 T1EP70 20198370 PTHR46673:SF1 4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN AMINO ACID TRANSPORTER HEAVY CHAIN SLC3A2 nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;branched-chain amino acid transport#GO:0015803;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;alanine transport#GO:0032328;import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039;L-leucine transport#GO:0015820;L-alpha-amino acid transmembrane transport#GO:1902475;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;apical plasma membrane#GO:0016324;apical part of cell#GO:0045177 HELRO|EnsemblGenome=HelroG73887|UniProtKB=T1G1K3 T1G1K3 20214951 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HELRO|EnsemblGenome=HelroG183673|UniProtKB=T1FK08 T1FK08 20209157 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184902|UniProtKB=T1FM54 T1FM54 20209903 PTHR11353:SF94 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT EPSILON primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;cytosol#GO:0005829;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG157178|UniProtKB=T1EM76 T1EM76 20197676 PTHR13200:SF0 EEF1A LYSINE METHYLTRANSFERASE 1 EEF1A LYSINE METHYLTRANSFERASE 1 lysine N-methyltransferase activity#GO:0016278;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276 HELRO|EnsemblGenome=HelroG89336|UniProtKB=T1G7C2 T1G7C2 20216969 PTHR11404:SF6 SUPEROXIDE DISMUTASE 2 SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG81861|UniProtKB=T1G4J6 T1G4J6 20215994 PTHR23101:SF122 RAB GDP/GTP EXCHANGE FACTOR RAB5 GDP_GTP EXCHANGE FACTOR nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG67090|UniProtKB=T1FYW1 T1FYW1 20214009 PTHR24329:SF543 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN CEH-17 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;system development#GO:0048731;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG190288|UniProtKB=T1FRV2 T1FRV2 20211549 PTHR13723:SF306 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG83561|UniProtKB=T1G572 T1G572 20216220 PTHR10358:SF6 ENDOSULFINE ENDOSULFINE, ISOFORM A phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG193300|UniProtKB=T1FUU9 T1FUU9 20212595 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89197|UniProtKB=T1G7A1 T1G7A1 20216948 PTHR24055:SF598 MITOGEN-ACTIVATED PROTEIN KINASE STRESS-ACTIVATED PROTEIN KINASE JNK protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Apoptosis signaling pathway#P00006>JNK#P00274;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Oxidative stress response#P00046>JNK1/2#P01129;Toll receptor signaling pathway#P00054>JNK#P01375;Parkinson disease#P00049>SAPK#P01219;Angiogenesis#P00005>JNK1#P00221;Ras Pathway#P04393>JNK#P04572;TGF-beta signaling pathway#P00052>JNK#P01284;FGF signaling pathway#P00021>JNK1-3#P00628;Integrin signalling pathway#P00034>Jnk#P00951;FAS signaling pathway#P00020>JNK#P00615;EGF receptor signaling pathway#P00018>JNK1-3#P00545 HELRO|EnsemblGenome=HelroG182723|UniProtKB=T1FIN3 T1FIN3 20208682 PTHR46464:SF2 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN-LIKE HELRO|EnsemblGenome=HelroG104674|UniProtKB=T1EDM9 T1EDM9 20194681 PTHR23338:SF17 SMALL NUCLEAR RIBONUCLEOPROTEIN SM SMALL NUCLEAR RIBONUCLEOPROTEIN SM D3 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;spliceosomal snRNP assembly#GO:0000387;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;nuclear protein-containing complex#GO:0140513;U2 snRNP#GO:0005686;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular membrane-bounded organelle#GO:0043231;U4 snRNP#GO:0005687;U2-type spliceosomal complex#GO:0005684;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188468|UniProtKB=T1FQ09 T1FQ09 20210906 PTHR12327:SF0 ALPHA-TUBULIN N-ACETYLTRANSFERASE 1 ALPHA-TUBULIN N-ACETYLTRANSFERASE 1 protein N-acyltransferase activity#GO:0140186;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 HELRO|EnsemblGenome=HelroG177905|UniProtKB=T1FCG2 T1FCG2 20206511 PTHR13270:SF14 PROTEIN C20ORF116-RELATED SEX DETERMINATION AND DOSAGE COMPENSATION PROTEIN SDC-2 HELRO|EnsemblGenome=HelroG171812|UniProtKB=T1F4Q3 T1F4Q3 20203802 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167518|UniProtKB=T1EZG1 T1EZG1 20201961 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG91764|UniProtKB=T1G885 T1G885 20217282 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG185578|UniProtKB=T1FN00 T1FN00 20210199 PTHR10300:SF14 CALCIPRESSIN PROTEIN SARAH phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;cell communication#GO:0007154 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG102482|UniProtKB=T1ED98 T1ED98 20194550 PTHR44340:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 10 ENDOPLASMIC RETICULUM DISULFIDE REDUCTASE DNAJC10 protein-disulfide reductase activity#GO:0015035;protein binding#GO:0005515;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;binding#GO:0005488;disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788 chaperone#PC00072 HELRO|EnsemblGenome=HelroG167031|UniProtKB=T1EYX4 T1EYX4 20201774 PTHR45598:SF5 PROTEIN CBG11839-RELATED 4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189601|UniProtKB=T1FR69 T1FR69 20211316 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG195013|UniProtKB=T1FWN4 T1FWN4 20213229 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837 multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;nervous system development#GO:0007399;embryo development#GO:0009790;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG106306|UniProtKB=T1EE17 T1EE17 20194819 PTHR46295:SF1 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058 endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090 HELRO|EnsemblGenome=HelroG70258|UniProtKB=T1G039 T1G039 20214437 PTHR24418:SF418 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FER protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;signaling receptor binding#GO:0005102;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;developmental process#GO:0032502;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG182182|UniProtKB=T1FHW0 T1FHW0 20208409 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185119|UniProtKB=T1FMF2 T1FMF2 20210001 PTHR18884:SF137 SEPTIN SEPTIN-7 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640;intracellular protein localization#GO:0008104;cytokinesis#GO:0000910;macromolecule localization#GO:0033036;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;cell division#GO:0051301 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG158306|UniProtKB=T1EMM4 T1EMM4 20197824 PTHR43785:SF12 GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE TYPE-1 GLUTAMINE SYNTHETASE 2 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG171137|UniProtKB=T1F3U5 T1F3U5 20203494 PTHR24412:SF489 KELCH PROTEIN RING CANAL KELCH PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192632|UniProtKB=T1FU53 T1FU53 20212349 PTHR31139:SF4 ECTOPIC P GRANULES PROTEIN 5 HOMOLOG ECTOPIC P GRANULES PROTEIN 5 HOMOLOG lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG93668|UniProtKB=T1G8X3 T1G8X3 20217520 PTHR12307:SF36 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT phosphatase binding#GO:0019902;binding#GO:0005488;polysaccharide binding#GO:0030247;enzyme binding#GO:0019899;protein binding#GO:0005515;carbohydrate binding#GO:0030246;protein phosphatase binding#GO:0019903 regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of polysaccharide metabolic process#GO:0032881;regulation of carbohydrate biosynthetic process#GO:0043255;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG176397|UniProtKB=T1FAH2 T1FAH2 20205821 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG145141|UniProtKB=T1EJI8 T1EJI8 20196738 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG171347|UniProtKB=T1F458 T1F458 20203607 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190700|UniProtKB=T1FS77 T1FS77 20211674 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 10 HELRO|EnsemblGenome=HelroG181576|UniProtKB=T1FH46 T1FH46 20208145 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG74874|UniProtKB=T1G1W9 T1G1W9 20215067 PTHR18934:SF99 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX37-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185477|UniProtKB=T1FMV4 T1FMV4 20210153 PTHR10502:SF247 ANNEXIN ANNEXIN B10 phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;ion binding#GO:0043167;binding#GO:0005488;phospholipid binding#GO:0005543;anion binding#GO:0043168;small molecule binding#GO:0036094 vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG95831|UniProtKB=T1G980 T1G980 20217627 PTHR47633:SF4 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84263|UniProtKB=T1G5G6 T1G5G6 20216313 PTHR12903:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L24 LARGE RIBOSOMAL SUBUNIT PROTEIN UL24M metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG159334|UniProtKB=T1ENW5 T1ENW5 20198265 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG67647|UniProtKB=T1FZ32 T1FZ32 20214080 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 TITIN-LIKE HELRO|EnsemblGenome=HelroG73994|UniProtKB=T1G1K9 T1G1K9 20214957 PTHR11239:SF14 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;transcription by RNA polymerase I#GO:0006360;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;catalytic complex#GO:1902494;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG154744|UniProtKB=T1ELF9 T1ELF9 20197409 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189471|UniProtKB=T1FR31 T1FR31 20211278 PTHR37456:SF15 SI:CH211-266K2.1 MULTIPLEXIN HELRO|EnsemblGenome=HelroG188473|UniProtKB=T1FQ11 T1FQ11 20210908 PTHR44267:SF1 WD REPEAT-CONTAINING PROTEIN 43 WD REPEAT-CONTAINING PROTEIN 43 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HELRO|EnsemblGenome=HelroG72682|UniProtKB=T1G138 T1G138 20214786 PTHR45871:SF1 N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycerolipid biosynthetic process#GO:0045017;carbohydrate derivative metabolic process#GO:1901135;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG158644|UniProtKB=T1EN27 T1EN27 20197977 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105779|UniProtKB=T1EDX6 T1EDX6 20194778 PTHR46342:SF1 ALPHA-CATULIN ALPHA-CATULIN intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 Wnt signaling pathway#P00057>alpha-catenin#P01471 HELRO|EnsemblGenome=HelroG102534|UniProtKB=T1EDA1 T1EDA1 20194553 PTHR45998:SF9 SERINE/THREONINE-PROTEIN KINASE 16 SERINE_THREONINE-PROTEIN KINASE 16 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG80714|UniProtKB=T1G442 T1G442 20215840 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG77287|UniProtKB=T1G2V8 T1G2V8 20215406 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG72558|UniProtKB=T1G118 T1G118 20214766 PTHR11011:SF129 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG65246|UniProtKB=T1FY50 T1FY50 20213748 PTHR10535:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383 nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG187749|UniProtKB=T1FPC6 T1FPC6 20210673 PTHR12227:SF0 GLYCERATE KINASE GLYCERATE KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065 HELRO|EnsemblGenome=HelroG66077|UniProtKB=T1FYG7 T1FYG7 20213865 PTHR21275:SF1 RWD DOMAIN-CONTAINING PROTEIN 4 RWD DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG191512|UniProtKB=T1FT21 T1FT21 20211968 PTHR45691:SF6 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG79849|UniProtKB=T1G3U4 T1G3U4 20215742 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG191912|UniProtKB=T1FTE8 T1FTE8 20212095 PTHR14463:SF5 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 2 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HELRO|EnsemblGenome=HelroG132173|UniProtKB=T1EHX4 T1EHX4 20196174 PTHR10026:SF13 CYCLIN LD24704P kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 kinase activator#PC00138;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG182086|UniProtKB=T1FHQ0 T1FHQ0 20208349 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG194672|UniProtKB=T1FWA8 T1FWA8 20213104 PTHR11731:SF193 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 9 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG188648|UniProtKB=T1FQ79 T1FQ79 20210976 PTHR23240:SF26 DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED 5' EXONUCLEASE APOLLO catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;damaged DNA binding#GO:0003684;DNA exonuclease activity#GO:0004529;DNA binding#GO:0003677;hydrolase activity#GO:0016787;5'-3' exonuclease activity#GO:0008409;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676;exonuclease activity#GO:0004527 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;double-strand break repair via nonhomologous end joining#GO:0006303;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;telomere organization#GO:0032200;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromosome#GO:0005694 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185760|UniProtKB=T1FN91 T1FN91 20210289 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 mRNA splicing#P00058>U5#P01474 HELRO|EnsemblGenome=HelroG69215|UniProtKB=T1FZR0 T1FZR0 20214308 PTHR43655:SF2 ATP-DEPENDENT PROTEASE AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG157599|UniProtKB=T1EMD7 T1EMD7 20197737 PTHR48033:SF9 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN TAR DNA-BINDING PROTEIN 43 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG170350|UniProtKB=T1F2Y7 T1F2Y7 20203186 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG184551|UniProtKB=T1FLG4 T1FLG4 20209663 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194316|UniProtKB=T1FVX3 T1FVX3 20212969 PTHR16002:SF4 TRANSMEMBRANE PROTEIN 248-LIKE TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167287|UniProtKB=T1EZ80 T1EZ80 20201880 PTHR19265:SF0 MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1 MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782 cilium#GO:0005929;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165 structural protein#PC00211 HELRO|EnsemblGenome=HelroG166504|UniProtKB=T1EY68 T1EY68 20201518 PTHR13542:SF0 LSM12 HOMOLOG PROTEIN LSM12 HELRO|EnsemblGenome=HelroG155789|UniProtKB=T1ELM4 T1ELM4 20197474 PTHR11937:SF596 ACTIN BRAHMA ASSOCIATED PROTEIN 55KD structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;chromatin binding#GO:0003682 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;protein acetyltransferase complex#GO:0031248;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG84028|UniProtKB=T1G5D5 T1G5D5 20216282 PTHR14027:SF2 RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG78151|UniProtKB=T1G388 T1G388 20215536 PTHR24115:SF1016 KINESIN-RELATED KINESIN FAMILY MEMBER 19A protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG163782|UniProtKB=T1EUG9 T1EUG9 20200219 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED protein binding#GO:0005515;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182558|UniProtKB=T1FIC5 T1FIC5 20208574 PTHR46462:SF3 UPSET, ISOFORM A UPSET, ISOFORM A regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;Rpd3L-Expanded complex#GO:0070210;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG63476|UniProtKB=T1FXG4 T1FXG4 20213512 PTHR16083:SF98 LEUCINE RICH REPEAT CONTAINING PROTEIN DISEASE RESISTANCE R13L4_SHOC-2-LIKE LRR DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173173|UniProtKB=T1F6I3 T1F6I3 20204432 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG178714|UniProtKB=T1FDM0 T1FDM0 20206919 PTHR12814:SF2 RNA-BINDING PROTEIN NOB1 RNA-BINDING PROTEIN NOB1 RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684 HELRO|EnsemblGenome=HelroG167002|UniProtKB=T1EYV6 T1EYV6 20201756 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68919|UniProtKB=T1FZL5 T1FZL5 20214263 PTHR24241:SF83 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 150-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171304|UniProtKB=T1F425 T1F425 20203574 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69527|UniProtKB=T1FZW5 T1FZW5 20214363 PTHR31699:SF1 NUDIX T16 FAMILY MEMBER U8 SNORNA-DECAPPING ENZYME catalytic activity#GO:0003824;snoRNA binding#GO:0030515;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity#GO:0016787;RNA binding#GO:0003723;nuclease activity#GO:0004518 mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG166057|UniProtKB=T1EXN4 T1EXN4 20201334 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164396|UniProtKB=T1EVD7 T1EVD7 20200537 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170858|UniProtKB=T1F3I7 T1F3I7 20203386 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG145076|UniProtKB=T1EJI5 T1EJI5 20196735 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;poly(A) binding#GO:0008143;nucleic acid binding#GO:0003676 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG157575|UniProtKB=T1EMD3 T1EMD3 20197733 PTHR11902:SF1 ENOLASE ENOLASE catalytic activity#GO:0003824;phosphopyruvate hydratase activity#GO:0004634;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693 cytosol#GO:0005829;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG191702|UniProtKB=T1FT80 T1FT80 20212027 PTHR24027:SF441 CADHERIN-23 CADHERIN DOMAIN-CONTAINING PROTEIN cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;cell motility#GO:0048870;cell migration#GO:0016477 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG87727|UniProtKB=T1G6U9 T1G6U9 20216796 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 metal ion transport#GO:0030001;action potential#GO:0001508;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG175341|UniProtKB=T1F962 T1F962 20205361 PTHR21041:SF17 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE DCST1 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 sperm-egg recognition#GO:0035036;sexual reproduction#GO:0019953;cell recognition#GO:0008037;cell-cell recognition#GO:0009988;single fertilization#GO:0007338;cellular process#GO:0009987;reproductive process#GO:0022414;fertilization#GO:0009566 intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HELRO|EnsemblGenome=HelroG191942|UniProtKB=T1FTF5 T1FTF5 20212102 PTHR24350:SF34 SERINE/THREONINE-PROTEIN KINASE IAL-RELATED AURORA KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 microtubule cytoskeleton organization#GO:0000226;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;mitotic spindle organization#GO:0007052;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996 intracellular organelle#GO:0043229;microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191380|UniProtKB=T1FSY0 T1FSY0 20211927 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG171151|UniProtKB=T1F3V4 T1F3V4 20203503 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 transcription coregulator activity#GO:0003712;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046 DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366 transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG104538|UniProtKB=T1EDM3 T1EDM3 20194675 PTHR19960:SF7 TEKTIN TEKTIN cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;organelle assembly#GO:0070925;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG119925|UniProtKB=T1EGP0 T1EGP0 20195740 PTHR11062:SF129 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-1 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375;glucuronosyltransferase activity#GO:0015020;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG161404|UniProtKB=T1ERG1 T1ERG1 20199161 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG90981|UniProtKB=T1G7Y2 T1G7Y2 20217179 PTHR24089:SF769 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SCAMC transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;organophosphate ester transport#GO:0015748;localization#GO:0051179;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;transport#GO:0006810;carbohydrate derivative transport#GO:1901264 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG182947|UniProtKB=T1FIY7 T1FIY7 20208786 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG156757|UniProtKB=T1EM06 T1EM06 20197606 PTHR23055:SF201 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG189554|UniProtKB=T1FR53 T1FR53 20211300 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription regulatory region nucleic acid binding#GO:0001067;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG98643|UniProtKB=T1G9P1 T1G9P1 20217787 PTHR13872:SF43 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;glycoprotein biosynthetic process#GO:0009101;protein modification process#GO:0036211;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG175527|UniProtKB=T1F9C9 T1F9C9 20205428 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG71646|UniProtKB=T1G0P7 T1G0P7 20214645 PTHR11080:SF35 PYRAZINAMIDASE/NICOTINAMIDASE NICOTINAMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;amidase activity#GO:0004040;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG153596|UniProtKB=T1EL89 T1EL89 20197339 PTHR12547:SF174 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36L2 molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164349|UniProtKB=T1EVA8 T1EVA8 20200508 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185672|UniProtKB=T1FN46 T1FN46 20210244 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG176575|UniProtKB=T1FAP0 T1FAP0 20205889 PTHR12147:SF22 METALLOPEPTIDASE M28 FAMILY MEMBER ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG159073|UniProtKB=T1ENJ9 T1ENJ9 20198149 PTHR23043:SF17 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PROTEIN SIMILAR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular homeostasis#GO:0019725;response to hypoxia#GO:0001666;intracellular chemical homeostasis#GO:0055082;regulation of biosynthetic process#GO:0009889;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;cellular response to hypoxia#GO:0071456;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG90253|UniProtKB=T1G7N4 T1G7N4 20217081 PTHR12127:SF25 MUCOLIPIN SD02261P channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;membrane#GO:0016020;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG83793|UniProtKB=T1G5A5 T1G5A5 20216252 PTHR11920:SF499 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG77555|UniProtKB=T1G2Z7 T1G2Z7 20215445 PTHR22883:SF40 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 regulation of cellular process#GO:0050794;protein targeting#GO:0006605;regulation of cell communication#GO:0010646;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;regulation of biological process#GO:0050789;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;protein targeting to membrane#GO:0006612;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG101596|UniProtKB=T1ED56 T1ED56 20194508 PTHR24072:SF156 RHO FAMILY GTPASE RHO-RELATED BTB DOMAIN CONTAINING, ISOFORM B GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;regulation of biological quality#GO:0065008;establishment or maintenance of cell polarity#GO:0007163;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of developmental process#GO:0050793;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;membrane#GO:0016020 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG170261|UniProtKB=T1F2U6 T1F2U6 20203145 PTHR24258:SF116 SERINE PROTEASE-RELATED ACROSIN-RELATED protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG193700|UniProtKB=T1FV99 T1FV99 20212745 PTHR22969:SF15 IKB KINASE FI05319P protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 positive regulation of gene expression#GO:0010628;positive regulation of response to biotic stimulus#GO:0002833;regulation of gene expression#GO:0010468;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biosynthetic process#GO:0009891;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of response to biotic stimulus#GO:0002831;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;positive regulation of type I interferon production#GO:0032481;positive regulation of response to external stimulus#GO:0032103;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;immune system process#GO:0002376;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86699|UniProtKB=T1G6F5 T1G6F5 20216652 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 developmental process#GO:0032502;cell fate specification#GO:0001708;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG159580|UniProtKB=T1EP68 T1EP68 20198368 PTHR31251:SF169 SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4 SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 13A-RELATED HELRO|EnsemblGenome=HelroG188683|UniProtKB=T1FQ91 T1FQ91 20210988 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;multicellular organism development#GO:0007275;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162327|UniProtKB=T1ESI4 T1ESI4 20199534 PTHR10217:SF637 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL EAG-LIKE K[+] CHANNEL, ISOFORM A voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG111800|UniProtKB=T1EFE8 T1EFE8 20195300 PTHR18034:SF4 CELL CYCLE CONTROL PROTEIN CWF22-RELATED NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribosomal small subunit biogenesis#GO:0042274;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG169264|UniProtKB=T1F1N6 T1F1N6 20202736 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186061|UniProtKB=T1FNM1 T1FNM1 20210418 PTHR43226:SF4 XAA-PRO AMINOPEPTIDASE 3 XAA-PRO AMINOPEPTIDASE 3 peptidase activity#GO:0008233;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG159625|UniProtKB=T1EP93 T1EP93 20198393 PTHR15111:SF2 RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3 UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1 phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;binding#GO:0005488;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of apoptotic process#GO:0043066;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of intrinsic apoptotic signaling pathway#GO:2001242;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of signal transduction#GO:0009968;negative regulation of programmed cell death#GO:0043069;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of apoptotic process#GO:0042981;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of DNA-templated transcription#GO:0045892;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG80090|UniProtKB=T1G3X6 T1G3X6 20215774 PTHR24416:SF647 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;nervous system development#GO:0007399;cell migration#GO:0016477;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159715|UniProtKB=T1EPC2 T1EPC2 20198422 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;transcription coregulator activity#GO:0003712;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG178740|UniProtKB=T1FDN5 T1FDN5 20206934 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG171696|UniProtKB=T1F4K3 T1F4K3 20203752 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG169608|UniProtKB=T1F258 T1F258 20202908 PTHR15708:SF4 ACTIN BUNDLING/MISSING IN METASTASIS-RELATED FI21477P1-RELATED actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;protein binding#GO:0005515 membrane organization#GO:0061024;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG66930|UniProtKB=T1FYT5 T1FYT5 20213983 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;epidermis development#GO:0008544;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG93365|UniProtKB=T1G8V4 T1G8V4 20217501 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN 7, ISOFORM A phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515 regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;localization#GO:0051179;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular component organization#GO:0016043;regulation of localization#GO:0032879;regulation of transport#GO:0051049;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG68869|UniProtKB=T1FZK7 T1FZK7 20214255 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68111|UniProtKB=T1FZA4 T1FZA4 20214152 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG160216|UniProtKB=T1EPZ7 T1EPZ7 20198647 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG143758|UniProtKB=T1EJC1 T1EJC1 20196671 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN 84-LIKE transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG158698|UniProtKB=T1EN50 T1EN50 20198000 PTHR24270:SF69 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG158856|UniProtKB=T1ENC4 T1ENC4 20198074 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189438|UniProtKB=T1FR21 T1FR21 20211268 PTHR21219:SF3 FI19613P1 FI19613P1 HELRO|EnsemblGenome=HelroG83972|UniProtKB=T1G5C3 T1G5C3 20216270 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG192663|UniProtKB=T1FU61 T1FU61 20212357 PTHR43344:SF2 PHOSPHOSERINE PHOSPHATASE PHOSPHOSERINE PHOSPHATASE magnesium ion binding#GO:0000287;cation binding#GO:0043169;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 Serine glycine biosynthesis#P02776>Phosphoserine phosphatase#P03159 HELRO|EnsemblGenome=HelroG190314|UniProtKB=T1FRW3 T1FRW3 20211560 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to heat#GO:0009408;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;response to stimulus#GO:0050896;protein folding#GO:0006457;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein refolding#GO:0042026 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG178474|UniProtKB=T1FD81 T1FD81 20206780 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG68803|UniProtKB=T1FZJ6 T1FZJ6 20214244 PTHR24416:SF631 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE STYK1 catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169845|UniProtKB=T1F2D4 T1F2D4 20202984 PTHR13800:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG182218|UniProtKB=T1FHY2 T1FHY2 20208431 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG63882|UniProtKB=T1FXL9 T1FXL9 20213567 PTHR23405:SF4 MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED PROTEIN MAK16 HOMOLOG gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG180275|UniProtKB=T1FFN7 T1FFN7 20207636 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72683|UniProtKB=T1G139 T1G139 20214787 PTHR11249:SF2 GLIAL FACTOR NATURATION FACTOR GLIA MATURATION FACTOR binding#GO:0005488;protein-containing complex binding#GO:0044877 regulation of cellular process#GO:0050794;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;negative regulation of cytoskeleton organization#GO:0051494;actin filament-based process#GO:0030029;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of actin nucleation#GO:0051125 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG193031|UniProtKB=T1FUJ6 T1FUJ6 20212492 PTHR15881:SF2 MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN positive regulation of immune system process#GO:0002684;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of immune effector process#GO:0002697;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG80748|UniProtKB=T1G449 T1G449 20215847 PTHR44133:SF2 CLEAVAGE STIMULATION FACTOR SUBUNIT 1 CLEAVAGE STIMULATION FACTOR SUBUNIT 1 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG173518|UniProtKB=T1F6X4 T1F6X4 20204573 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175359|UniProtKB=T1F970 T1F970 20205369 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154179|UniProtKB=T1ELD9 T1ELD9 20197389 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG170165|UniProtKB=T1F2Q6 T1F2Q6 20203105 PTHR35270:SF2 FUSELESS, ISOFORM A SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG155340|UniProtKB=T1ELI0 T1ELI0 20197430 PTHR11941:SF45 ENOYL-COA HYDRATASE-RELATED ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;lyase#PC00144;hydratase#PC00120 HELRO|EnsemblGenome=HelroG167054|UniProtKB=T1EYY4 T1EYY4 20201784 PTHR10925:SF5 N-ACETYLTRANSFERASE 10 RNA CYTIDINE ACETYLTRANSFERASE catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a tRNA#GO:0140101;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;catalytic activity, acting on RNA#GO:0140098;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;tRNA modification#GO:0006400;tRNA wobble base modification#GO:0002097;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;tRNA metabolic process#GO:0006399;ribosomal small subunit biogenesis#GO:0042274 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG98483|UniProtKB=T1G9N2 T1G9N2 20217778 PTHR11452:SF83 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG181144|UniProtKB=T1FGN8 T1FGN8 20207987 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153373|UniProtKB=T1EL56 T1EL56 20197368 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG85052|UniProtKB=T1G5S3 T1G5S3 20216420 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235 catabolic process#GO:0009056;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG157477|UniProtKB=T1EMB8 T1EMB8 20197718 PTHR23506:SF13 GH10249P VESICULAR ACETYLCHOLINE TRANSPORTER monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoamine transmembrane transporter activity#GO:0008504;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078 anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular process#GO:0009987;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537 clathrin vesicle coat#GO:0030125;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;endocytic vesicle#GO:0030139;coated membrane#GO:0048475;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;clathrin-coated vesicle#GO:0030136;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;axon terminus#GO:0043679;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;axon#GO:0030424;AP-1 adaptor complex#GO:0030121;trans-Golgi network transport vesicle#GO:0030140;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;membrane protein complex#GO:0098796;distal axon#GO:0150034;terminal bouton#GO:0043195;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;neuron projection terminus#GO:0044306 transporter#PC00227;secondary carrier transporter#PC00258 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>VAChT#P01065;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078 HELRO|EnsemblGenome=HelroG185698|UniProtKB=T1FN59 T1FN59 20210257 PTHR22572:SF104 SUGAR-1-PHOSPHATE GUANYL TRANSFERASE MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE REGULATORY SUBUNIT ALPHA nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220 Mannose metabolism#P02752>Mannose 1-P guanylyl transferase#P03018 HELRO|EnsemblGenome=HelroG185281|UniProtKB=T1FML8 T1FML8 20210067 PTHR22739:SF7 STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED EG:152A3.3 PROTEIN-RELATED positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of Rho protein signal transduction#GO:0035023;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of signal transduction#GO:0009966;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;sarcomere#GO:0030017;myofibril#GO:0030016;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292 HELRO|EnsemblGenome=HelroG179299|UniProtKB=T1FEI2 T1FEI2 20207231 PTHR24026:SF141 FAT ATYPICAL CADHERIN-RELATED CADHERIN DOMAIN-CONTAINING PROTEIN animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;neuron differentiation#GO:0030182;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron projection development#GO:0031175;cell-cell adhesion#GO:0098609;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667 cell-cell junction#GO:0005911;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG72182|UniProtKB=T1G0W9 T1G0W9 20214717 PTHR12277:SF207 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD13 catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 serine protease#PC00203 HELRO|EnsemblGenome=HelroG90549|UniProtKB=T1G7T0 T1G7T0 20217127 PTHR47958:SF195 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG185957|UniProtKB=T1FNH5 T1FNH5 20210372 PTHR20920:SF5 RPE-SPONDIN VEXED, ISOFORM B HELRO|EnsemblGenome=HelroG103882|UniProtKB=T1EDI1 T1EDI1 20194633 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG84500|UniProtKB=T1G5J2 T1G5J2 20216339 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536 plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG192764|UniProtKB=T1FU97 T1FU97 20212393 PTHR15508:SF8 RIBOSOMAL PROTEIN S6 KINASE LD24550P protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG154361|UniProtKB=T1ELE6 T1ELE6 20197396 PTHR10681:SF182 THIOREDOXIN PEROXIDASE THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 cellular process#GO:0009987;response to stress#GO:0006950;hydrogen peroxide metabolic process#GO:0042743;homeostatic process#GO:0042592;catabolic process#GO:0009056;response to stimulus#GO:0050896;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;response to oxidative stress#GO:0006979 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG157577|UniProtKB=T1EMD4 T1EMD4 20197734 PTHR11239:SF1 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on RNA#GO:0140098 cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;response to stimulus#GO:0050896;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;response to stress#GO:0006950;DNA-templated transcription elongation#GO:0006354;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991 DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG97320|UniProtKB=T1G9G4 T1G9G4 20217711 PTHR45911:SF10 C2 DOMAIN-CONTAINING PROTEIN MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of secretion#GO:0051046;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynapse#GO:0098793;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202 HELRO|EnsemblGenome=HelroG161529|UniProtKB=T1ERL4 T1ERL4 20199214 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG189500|UniProtKB=T1FR38 T1FR38 20211285 PTHR22881:SF48 BROMODOMAIN CONTAINING PROTEIN BROMODOMAIN CONTAINING 7_9 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG77701|UniProtKB=T1G325 T1G325 20215473 PTHR15486:SF103 ANCIENT UBIQUITOUS PROTEIN LIPID DROPLET-REGULATING VLDL ASSEMBLY FACTOR AUP1 cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173597|UniProtKB=T1F703 T1F703 20204602 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE MGP4 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG178091|UniProtKB=T1FCQ2 T1FCQ2 20206601 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181074|UniProtKB=T1FGL0 T1FGL0 20207959 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 cell motility#GO:0048870;endothelial cell migration#GO:0043542;cell migration#GO:0016477;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG108146|UniProtKB=T1EEF9 T1EEF9 20194961 PTHR43807:SF23 FI04487P FI04487P transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220;transaminase#PC00216 HELRO|EnsemblGenome=HelroG72389|UniProtKB=T1G0Z4 T1G0Z4 20214742 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159243|UniProtKB=T1ENS5 T1ENS5 20198225 PTHR13379:SF0 UNCHARACTERIZED DUF1308 UPF0415 PROTEIN C7ORF25 HELRO|EnsemblGenome=HelroG158167|UniProtKB=T1EMJ9 T1EMJ9 20197799 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG110606|UniProtKB=T1EF35 T1EF35 20195187 PTHR31353:SF1 FAM98 PROTEIN FAM98B catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG86431|UniProtKB=T1G6C0 T1G6C0 20216617 PTHR23349:SF112 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST 48 RELATED 1, ISOFORM B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG131366|UniProtKB=T1EHV7 T1EHV7 20196157 PTHR12537:SF195 RNA BINDING PROTEIN PUMILIO-RELATED MATERNAL PROTEIN PUMILIO mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177898|UniProtKB=T1FCG0 T1FCG0 20206509 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG70893|UniProtKB=T1G0D8 T1G0D8 20214536 PTHR12378:SF80 DESUMOYLATING ISOPEPTIDASE IP06716P-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;deubiquitinase activity#GO:0101005 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG146547|UniProtKB=T1EJT1 T1EJT1 20196831 PTHR11544:SF148 COLD SHOCK DOMAIN CONTAINING PROTEINS LD37574P binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157191|UniProtKB=T1EM77 T1EM77 20197677 PTHR11264:SF0 URACIL-DNA GLYCOSYLASE URACIL-DNA GLYCOSYLASE DNA N-glycosylase activity#GO:0019104;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;hydrolase activity#GO:0016787 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;base-excision repair#GO:0006284;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG173109|UniProtKB=T1F6D3 T1F6D3 20204382 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112963|UniProtKB=T1EFN6 T1EFN6 20195388 PTHR24104:SF41 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED PROTEIN BRAIN TUMOR ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;translation regulator activity#GO:0045182;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of translation#GO:0017148;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of metabolic process#GO:0009892;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein polyubiquitination#GO:0000209;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171434|UniProtKB=T1F499 T1F499 20203648 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112224|UniProtKB=T1EFH9 T1EFH9 20195331 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG191323|UniProtKB=T1FSV9 T1FSV9 20211906 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82751|UniProtKB=T1G4W1 T1G4W1 20216109 PTHR24353:SF111 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED cellular process#GO:0009987;cellular response to stimulus#GO:0051716;receptor guanylyl cyclase signaling pathway#GO:0007168;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Endothelin signaling pathway#P00019>PKG#P00567 HELRO|EnsemblGenome=HelroG155706|UniProtKB=T1ELL1 T1ELL1 20197461 PTHR15139:SF0 TUBULIN FOLDING COFACTOR C TUBULIN-SPECIFIC CHAPERONE C cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG175054|UniProtKB=T1F8S6 T1F8S6 20205225 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG185542|UniProtKB=T1FMY5 T1FMY5 20210184 PTHR12001:SF89 GERANYLGERANYL PYROPHOSPHATE SYNTHASE ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 metabolic process#GO:0008152;isoprenoid biosynthetic process#GO:0008299;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;ketone metabolic process#GO:0042180;ubiquinone biosynthetic process#GO:0006744;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Dimethylallyl trans-transferase#P00490 HELRO|EnsemblGenome=HelroG111155|UniProtKB=T1EF89 T1EF89 20195241 PTHR10797:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779 CCR4-NOT complex#GO:0030014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176164|UniProtKB=T1FA86 T1FA86 20205735 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159889|UniProtKB=T1EPI2 T1EPI2 20198482 PTHR12598:SF0 COPPER HOMEOSTASIS PROTEIN CUTC COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;copper ion binding#GO:0005507;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG101345|UniProtKB=T1ED41 T1ED41 20194494 PTHR43715:SF1 GDP-MANNOSE 4,6-DEHYDRATASE GDP-MANNOSE 4,6 DEHYDRATASE dehydratase#PC00091;lyase#PC00144 Mannose metabolism#P02752>GDP-Mannose 4,6-dehydratase#P03015 HELRO|EnsemblGenome=HelroG166845|UniProtKB=T1EYM2 T1EYM2 20201672 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177475|UniProtKB=T1FBR4 T1FBR4 20206263 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174218|UniProtKB=T1F7T7 T1F7T7 20204886 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173488|UniProtKB=T1F6V7 T1F6V7 20204556 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG177887|UniProtKB=T1FCF3 T1FCF3 20206502 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG162424|UniProtKB=T1ESM8 T1ESM8 20199578 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A catalytic activity#GO:0003824;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 catabolic process#GO:0009056;sulfur compound catabolic process#GO:0044273;cellular process#GO:0009987;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158094|UniProtKB=T1EMJ4 T1EMJ4 20197794 PTHR13822:SF7 ATP SYNTHASE DELTA/EPSILON CHAIN ATP SYNTHASE F(1) COMPLEX SUBUNIT DELTA, MITOCHONDRIAL channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874 purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;purine nucleoside triphosphate biosynthetic process#GO:0009145;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate biosynthetic process#GO:1901293;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;ribose phosphate biosynthetic process#GO:0046390;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;proton-transporting ATP synthase complex#GO:0045259;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;proton-transporting two-sector ATPase complex#GO:0016469;catalytic complex#GO:1902494;cation channel complex#GO:0034703 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG120487|UniProtKB=T1EGQ1 T1EGQ1 20195751 PTHR23337:SF3 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 ATPASE MORC2 HELRO|EnsemblGenome=HelroG190380|UniProtKB=T1FRY0 T1FRY0 20211577 PTHR46908:SF4 CUBILIN-LIKE PROTEIN CUBILIN HOMOLOG HELRO|EnsemblGenome=HelroG153295|UniProtKB=T1EL27 T1EL27 20197277 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185017|UniProtKB=T1FMA2 T1FMA2 20209951 PTHR12439:SF11 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE HELRO|EnsemblGenome=HelroG79167|UniProtKB=T1G3L1 T1G3L1 20215659 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N(6)-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT METTL3 methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;mRNA metabolic process#GO:0016071;cellular process#GO:0009987;mRNA modification#GO:0016556;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;methyltransferase complex#GO:0034708;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG167766|UniProtKB=T1EZS2 T1EZS2 20202072 PTHR24278:SF19 COAGULATION FACTOR DELTA-LIKE PROTEIN peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG86632|UniProtKB=T1G6E7 T1G6E7 20216644 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HELRO|EnsemblGenome=HelroG154688|UniProtKB=T1ELF6 T1ELF6 PTHR11214:SF219 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG150812|UniProtKB=T1EKH5 T1EKH5 20197075 PTHR44899:SF11 CAMK FAMILY PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG191977|UniProtKB=T1FTH3 T1FTH3 20212120 PTHR11890:SF44 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER SOLUBLE INTERFERON ALPHA_BETA RECEPTOR OPG204 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG110566|UniProtKB=T1EF32 T1EF32 20195184 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG178952|UniProtKB=T1FDY2 T1FDY2 20207031 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG106117|UniProtKB=T1EE02 T1EE02 20194804 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;cation binding#GO:0043169;metal ion binding#GO:0046872;lyase activity#GO:0016829;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 homeostatic process#GO:0042592;carbohydrate metabolic process#GO:0005975;hexose biosynthetic process#GO:0019319;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;response to glucose#GO:0009749;response to nutrient levels#GO:0031667;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;carbohydrate homeostasis#GO:0033500;response to hexose#GO:0009746;carboxylic acid metabolic process#GO:0019752;intracellular glucose homeostasis#GO:0001678;response to carbohydrate#GO:0009743;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to monosaccharide#GO:0034284;carbohydrate biosynthetic process#GO:0016051;response to chemical#GO:0042221;response to lipid#GO:0033993;alcohol biosynthetic process#GO:0046165;gluconeogenesis#GO:0006094;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to stress#GO:0006950;glucose homeostasis#GO:0042593;glucose metabolic process#GO:0006006;chemical homeostasis#GO:0048878;cellular response to glucose stimulus#GO:0071333;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;monosaccharide metabolic process#GO:0005996 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG89869|UniProtKB=T1G7I5 T1G7I5 20217032 PTHR21431:SF0 PREFOLDIN SUBUNIT 6 PREFOLDIN SUBUNIT 6 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186317|UniProtKB=T1FNY5 T1FNY5 20210532 PTHR11662:SF465 SOLUTE CARRIER FAMILY 17 SIALIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG193757|UniProtKB=T1FVB7 T1FVB7 20212763 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of gene expression#GO:0010629;regulation of metabolic process#GO:0019222;negative regulation of biological process#GO:0048519;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG173575|UniProtKB=T1F6Z4 T1F6Z4 20204593 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR ALLATOSTATIN A RECEPTOR 2, ISOFORM A G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG106059|UniProtKB=T1EDZ8 T1EDZ8 20194800 PTHR11468:SF13 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;generation of precursor metabolites and energy#GO:0006091;glycogen catabolic process#GO:0005980;cellular process#GO:0009987;carbohydrate catabolic process#GO:0016052;energy reserve metabolic process#GO:0006112;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976;carbohydrate metabolic process#GO:0005975;glucan catabolic process#GO:0009251;glycogen metabolic process#GO:0005977;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;polysaccharide catabolic process#GO:0000272 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG121430|UniProtKB=T1EGS0 T1EGS0 20195770 PTHR11229:SF8 50S RIBOSOMAL PROTEIN L3 LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG163594|UniProtKB=T1EU95 T1EU95 20200145 PTHR14605:SF1 CHST5 PROTEIN TRANSMEMBRANE PROTEIN 231 plasma membrane bounded cell projection assembly#GO:0120031;regulation of localization#GO:0032879;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;regulation of protein localization#GO:0032880;cilium organization#GO:0044782;regulation of biological process#GO:0050789;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030 ciliary transition zone#GO:0035869;cilium#GO:0005929;cell projection membrane#GO:0031253;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;ciliary membrane#GO:0060170;cell projection#GO:0042995;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG188099|UniProtKB=T1FPM8 T1FPM8 20210775 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG191549|UniProtKB=T1FT25 T1FT25 20211972 PTHR14139:SF2 CALSYNTENIN CALSYNTENIN-1 cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;cell adhesion#GO:0007155;positive regulation of cellular component organization#GO:0051130;regulation of biological quality#GO:0065008;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of cellular component biogenesis#GO:0044087;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;positive regulation of developmental process#GO:0051094;positive regulation of synapse assembly#GO:0051965;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;positive regulation of cellular component biogenesis#GO:0044089;regulation of synapse assembly#GO:0051963 postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cell surface#GO:0009986;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG98836|UniProtKB=T1G9Q1 T1G9Q1 20217797 PTHR12126:SF11 NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL binding#GO:0005488;protein-containing complex binding#GO:0044877 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG88758|UniProtKB=T1G760 T1G760 20216907 PTHR43157:SF74 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED DEHYDROGENASES, SHORT CHAIN-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG79030|UniProtKB=T1G3I8 T1G3I8 20215636 PTHR12027:SF70 WNT RELATED PROTEIN WNT-16 molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;system development#GO:0048731;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HELRO|EnsemblGenome=HelroG192604|UniProtKB=T1FU43 T1FU43 20212339 PTHR19872:SF7 UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG87535|UniProtKB=T1G6R8 T1G6R8 20216765 PTHR23506:SF45 GH10249P GH10249P solute:sodium symporter activity#GO:0015370;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;cellular localization#GO:0051641;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;neuron projection terminus#GO:0044306;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;intracellular membrane-bounded organelle#GO:0043231;distal axon#GO:0150034;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle membrane#GO:0031090;axon terminus#GO:0043679;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424 HELRO|EnsemblGenome=HelroG194659|UniProtKB=T1FWA4 T1FWA4 20213100 PTHR22767:SF3 N-TERMINAL ACETYLTRANSFERASE-RELATED N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG70359|UniProtKB=T1G054 T1G054 20214452 PTHR10913:SF84 FOLLISTATIN-RELATED AGRIN cellular developmental process#GO:0048869;cell differentiation#GO:0030154;cellular process#GO:0009987;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG176749|UniProtKB=T1FAV5 T1FAV5 20205954 PTHR19960:SF11 TEKTIN LD08455P plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;organelle assembly#GO:0070925 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG195136|UniProtKB=T1FWS7 T1FWS7 20213272 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG66000|UniProtKB=T1FYF9 T1FYF9 20213857 PTHR24115:SF1026 KINESIN-RELATED KINESIN-LIKE PROTEIN protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 organelle assembly#GO:0070925;nuclear division#GO:0000280;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;mitotic spindle organization#GO:0007052;chromosome segregation#GO:0007059;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG69135|UniProtKB=T1FZQ1 T1FZQ1 20214299 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 DNA endonuclease activity#GO:0004520;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;exonuclease activity#GO:0004527;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;DNA exonuclease activity#GO:0004529;hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 HELRO|EnsemblGenome=HelroG185641|UniProtKB=T1FN29 T1FN29 20210228 PTHR24031:SF84 RNA HELICASE EUKARYOTIC INITIATION FACTOR 4A cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 intracellular protein-containing complex#GO:0140535;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG86367|UniProtKB=T1G6B3 T1G6B3 20216610 PTHR10799:SF973 SNF2/RAD54 HELICASE FAMILY BRAHMA CHROMATIN-REMODELING COMPLEX ATPASE SUBUNIT ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;heterochromatin formation#GO:0031507;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG181350|UniProtKB=T1FGX1 T1FGX1 20208070 PTHR35270:SF2 FUSELESS, ISOFORM A SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG73057|UniProtKB=T1G193 T1G193 20214841 PTHR18063:SF6 NF-E2 INDUCIBLE PROTEIN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;carboxypeptidase activity#GO:0004180;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;deubiquitinase activity#GO:0101005 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG178416|UniProtKB=T1FD51 T1FD51 20206750 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG73695|UniProtKB=T1G1H3 T1G1H3 20214921 PTHR24406:SF23 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG100509|UniProtKB=T1ED00 T1ED00 20194452 PTHR11685:SF475 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ARIH1 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG90060|UniProtKB=T1G7K5 T1G7K5 20217052 PTHR12263:SF0 VACUOLAR ATP SYNTHASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078 localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;ATPase complex#GO:1904949;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG182466|UniProtKB=T1FI87 T1FI87 20208536 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193990|UniProtKB=T1FVJ8 T1FVJ8 20212844 PTHR12358:SF116 SPHINGOSINE KINASE ACYLGLYCEROL KINASE, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;sphingoid biosynthetic process#GO:0046520;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610 transferase#PC00220;metabolite interconversion enzyme#PC00262;kinase#PC00137 HELRO|EnsemblGenome=HelroG117169|UniProtKB=T1EGK8 T1EGK8 20195708 PTHR14025:SF20 FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER FANCONI ANEMIA GROUP M PROTEIN helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;four-way junction DNA binding#GO:0000400;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;response to stress#GO:0006950;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG163167|UniProtKB=T1ETR1 T1ETR1 20199961 PTHR12357:SF3 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING PROTEIN 1 protein-RNA adaptor activity#GO:0140517;protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;molecular adaptor activity#GO:0060090;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleic acid biosynthetic process#GO:0141187;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;regulation of mRNA splicing, via spliceosome#GO:0048024;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192700|UniProtKB=T1FU76 T1FU76 20212372 PTHR10104:SF1 STATHMIN STATHMIN, ISOFORM D protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 supramolecular fiber organization#GO:0097435;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;regulation of microtubule-based process#GO:0032886;protein-containing complex disassembly#GO:0032984;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;protein depolymerization#GO:0051261;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;microtubule polymerization or depolymerization#GO:0031109;neuron development#GO:0048666;cellular component disassembly#GO:0022411;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;nervous system development#GO:0007399;microtubule depolymerization#GO:0007019;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175 neuron projection#GO:0043005;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG177783|UniProtKB=T1FC93 T1FC93 20206442 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190619|UniProtKB=T1FS53 T1FS53 20211650 PTHR10026:SF7 CYCLIN CYCLIN-C cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG87690|UniProtKB=T1G6U3 T1G6U3 20216790 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG188312|UniProtKB=T1FPV1 T1FPV1 20210848 PTHR24228:SF59 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR NEUROPEPTIDE RECEPTOR 15 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG72990|UniProtKB=T1G184 T1G184 20214832 PTHR11727:SF34 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;rRNA methylation#GO:0031167;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG172168|UniProtKB=T1F538 T1F538 20203937 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG134508|UniProtKB=T1EI50 T1EI50 20196250 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 purine-containing compound catabolic process#GO:0072523;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside catabolic process#GO:0006152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule biosynthetic process#GO:0044283;purine nucleobase metabolic process#GO:0006144;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound catabolic process#GO:1901658;adenosine metabolic process#GO:0046085;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;nucleoside catabolic process#GO:0009164;purine-containing compound biosynthetic process#GO:0072522;purine nucleoside metabolic process#GO:0042278;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cytosol#GO:0005829 deaminase#PC00088 HELRO|EnsemblGenome=HelroG180796|UniProtKB=T1FGA3 T1FGA3 20207852 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192438|UniProtKB=T1FTY7 T1FTY7 20212284 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;immune system process#GO:0002376;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG156427|UniProtKB=T1ELW4 T1ELW4 20197564 PTHR15377:SF3 TRANSCRIPTION ELONGATION REGULATOR 1 WW DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;RNA polymerase binding#GO:0070063;binding#GO:0005488;transcription coregulator activity#GO:0003712 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG144452|UniProtKB=T1EJE9 T1EJE9 20196699 PTHR22883:SF11 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC21 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67530|UniProtKB=T1FZ23 T1FZ23 20214071 PTHR24347:SF459 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 HOMOLOG-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG95876|UniProtKB=T1G985 T1G985 20217632 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE transcription coactivator activity#GO:0003713;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transcription regulator activity#GO:0140110;binding#GO:0005488;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;chromatin DNA binding#GO:0031490;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;histone acetyltransferase activity#GO:0004402;DNA binding#GO:0003677;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;DPP-SCW signaling pathway#P06212>NEJ#P06260;p53 pathway#P00059>CBP#P04623;Huntington disease#P00029>CBP#P00777;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;DPP signaling pathway#P06213>NEJ#P06284;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295 HELRO|EnsemblGenome=HelroG166534|UniProtKB=T1EY80 T1EY80 20201530 PTHR28634:SF1 ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1 ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG186065|UniProtKB=T1FNM2 T1FNM2 20210419 PTHR11843:SF0 40S RIBOSOMAL PROTEIN S12 SMALL RIBOSOMAL SUBUNIT PROTEIN ES12 cellular component biogenesis#GO:0044085;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;ribosome biogenesis#GO:0042254;ribosomal small subunit biogenesis#GO:0042274;translation#GO:0006412;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG183751|UniProtKB=T1FK52 T1FK52 20209201 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71733|UniProtKB=T1G0Q9 T1G0Q9 20214657 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG191972|UniProtKB=T1FTH0 T1FTH0 20212117 PTHR15052:SF2 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2 double-stranded DNA binding#GO:0003690;rDNA binding#GO:0000182;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;rRNA transcription#GO:0009303;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG112672|UniProtKB=T1EFL2 T1EFL2 20195364 PTHR21245:SF15 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING PROTEIN 46-LIKE PROTEIN mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159370|UniProtKB=T1ENY5 T1ENY5 20198285 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194812|UniProtKB=T1FWF9 T1FWF9 20213154 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189295|UniProtKB=T1FQX5 T1FQX5 20211222 PTHR33936:SF24 PROTEIN CBG17840 C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172284|UniProtKB=T1F565 T1F565 20203964 PTHR23216:SF2 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG79262|UniProtKB=T1G3L8 T1G3L8 20215666 PTHR45810:SF9 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG188959|UniProtKB=T1FQI2 T1FQI2 20211079 PTHR46512:SF1 PEPTIDYLPROLYL ISOMERASE PEPTIDYLPROLYL ISOMERASE protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG185510|UniProtKB=T1FMW9 T1FMW9 20210168 PTHR46088:SF1 TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194295|UniProtKB=T1FVW6 T1FVW6 20212962 PTHR11384:SF67 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1 transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;ATP binding#GO:0005524;transmembrane transporter activity#GO:0022857;nucleotide binding#GO:0000166;monocarboxylic acid transmembrane transporter activity#GO:0008028;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168 small molecule catabolic process#GO:0044282;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;cellular component organization#GO:0016043;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;transmembrane transport#GO:0055085;cellular localization#GO:0051641;peroxisome organization#GO:0007031;oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;cellular process#GO:0009987;lipid catabolic process#GO:0016042;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;fatty acid oxidation#GO:0019395;metabolic process#GO:0008152;carboxylic acid transmembrane transport#GO:1905039;catabolic process#GO:0009056;primary metabolic process#GO:0044238;monocarboxylic acid transport#GO:0015718;peroxisomal transport#GO:0043574;lipid oxidation#GO:0034440;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid catabolic process#GO:0072329;lipid transport#GO:0006869;carboxylic acid catabolic process#GO:0046395;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid modification#GO:0030258;transport#GO:0006810;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;intracellular transport#GO:0046907 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG184540|UniProtKB=T1FLF4 T1FLF4 20209653 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157163|UniProtKB=T1EM73 T1EM73 20197673 PTHR45809:SF3 VIRAL IAP-ASSOCIATED FACTOR HOMOLOG PHOSDUCIN-LIKE PROTEIN 2 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG189633|UniProtKB=T1FR80 T1FR80 20211327 PTHR46035:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 4 HSP70_HSP90 CO-CHAPERONE CNS1 HOMOLOG heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG77826|UniProtKB=T1G347 T1G347 20215495 PTHR12294:SF1 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;homeostatic process#GO:0042592;mitochondrial calcium ion homeostasis#GO:0051560 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle membrane#GO:0031090;transporter complex#GO:1990351;inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;cytoplasm#GO:0005737;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG190818|UniProtKB=T1FSB5 T1FSB5 20211712 PTHR24370:SF10 OPTICIN LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG193953|UniProtKB=T1FVI6 T1FVI6 20212832 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG156412|UniProtKB=T1ELV7 T1ELV7 20197557 PTHR10971:SF36 MRNA EXPORT FACTOR AND BUB3 MITOTIC CHECKPOINT PROTEIN BUB3 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular process#GO:0009987;signal transduction#GO:0007165;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of sister chromatid segregation#GO:0033046;regulation of cell cycle process#GO:0010564;regulation of chromosome separation#GO:1905818;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of chromosome segregation#GO:0051985;negative regulation of cell cycle#GO:0045786;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;negative regulation of chromosome organization#GO:2001251;intracellular signal transduction#GO:0035556;regulation of mitotic sister chromatid segregation#GO:0033047;cell communication#GO:0007154;regulation of mitotic cell cycle#GO:0007346;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;regulation of mitotic sister chromatid separation#GO:0010965 condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;condensed chromosome, centromeric region#GO:0000779;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;kinetochore#GO:0000776;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG145344|UniProtKB=T1EJK2 T1EJK2 20196752 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG105275|UniProtKB=T1EDS7 T1EDS7 20194729 PTHR10590:SF24 SODIUM/NUCLEOSIDE COTRANSPORTER CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1-RELATED secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;nucleoside transmembrane transporter activity#GO:0005337;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;symporter activity#GO:0015293;nucleobase-containing compound transmembrane transporter activity#GO:0015932;solute:sodium symporter activity#GO:0015370;carbohydrate derivative transmembrane transporter activity#GO:1901505;monoatomic cation transmembrane transporter activity#GO:0008324 nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG86766|UniProtKB=T1G6G7 T1G6G7 20216664 PTHR12103:SF15 5'-NUCLEOTIDASE DOMAIN-CONTAINING 5' NUCLEOTIDASE B, ISOFORM G hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 ribonucleotide metabolic process#GO:0009259;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleobase-containing compound metabolic process#GO:0006139 phosphatase#PC00181;hydrolase#PC00121;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG191501|UniProtKB=T1FT17 T1FT17 20211964 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;kinase inhibitor activity#GO:0019210;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme inhibitor activity#GO:0004857 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194612|UniProtKB=T1FW88 T1FW88 20213084 PTHR45736:SF1 ZINC FINGER MYM-TYPE PROTEIN WITHOUT CHILDREN, ISOFORM B zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG182196|UniProtKB=T1FHW8 T1FHW8 20208417 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG166789|UniProtKB=T1EYJ3 T1EYJ3 20201643 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115679|UniProtKB=T1EG99 T1EG99 20195601 PTHR19850:SF36 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;G protein-coupled dopamine receptor signaling pathway#GO:0007212;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987 cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;cellular anatomical structure#GO:0110165 heterotrimeric G-protein#PC00117;G-protein#PC00020;protein-binding activity modulator#PC00095 Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta5L#P00748;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;PI3 kinase pathway#P00048>Gbetagamma#P01188;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Enkephalin release#P05913>G-Protein (i)#P05974;Enkephalin release#P05913>G-Protein (s)#P05977;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085 HELRO|EnsemblGenome=HelroG180922|UniProtKB=T1FGF2 T1FGF2 20207901 PTHR22738:SF10 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194551|UniProtKB=T1FW68 T1FW68 20213064 PTHR11139:SF1 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;DNA damage response#GO:0006974;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular response to stress#GO:0033554 H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;SAGA complex#GO:0000124;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SAGA-type complex#GO:0070461;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG166831|UniProtKB=T1EYL4 T1EYL4 20201664 PTHR47577:SF5 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 6 HELRO|EnsemblGenome=HelroG158397|UniProtKB=T1EMR3 T1EMR3 20197863 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG172965|UniProtKB=T1F681 T1F681 20204330 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112476|UniProtKB=T1EFK2 T1EFK2 20195354 PTHR46174:SF1 CXXC-TYPE ZINC FINGER PROTEIN 1 CXXC-TYPE ZINC FINGER PROTEIN 1 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG74952|UniProtKB=T1G1Y5 T1G1Y5 20215083 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG114857|UniProtKB=T1EG50 T1EG50 20195552 PTHR12461:SF43 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED HSPB1-ASSOCIATED PROTEIN 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;dioxygenase activity#GO:0051213 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82058|UniProtKB=T1G4M3 T1G4M3 20216021 PTHR21245:SF10 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN PROTEIN TUMOROUS TESTIS-RELATED mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177281|UniProtKB=T1FBG1 T1FBG1 20206160 PTHR31395:SF26 SHISA GEO05642P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG153336|UniProtKB=T1EL41 T1EL41 20197291 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG68175|UniProtKB=T1FZB4 T1FZB4 20214162 PTHR24056:SF594 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 5 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 axonogenesis#GO:0007409;neuron development#GO:0048666;neuron apoptotic process#GO:0051402;cellular localization#GO:0051641;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;establishment of organelle localization#GO:0051656;anatomical structure morphogenesis#GO:0009653;apoptotic process#GO:0006915;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;establishment of vesicle localization#GO:0051650;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;synaptic vesicle localization#GO:0097479;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;neuron projection development#GO:0031175;synaptic vesicle transport#GO:0048489;system development#GO:0048731;localization#GO:0051179;anatomical structure development#GO:0048856;organelle localization#GO:0051640;cell death#GO:0008219;programmed cell death#GO:0012501;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;vesicle localization#GO:0051648;axon development#GO:0061564 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Axon guidance mediated by semaphorins#P00007>Cdk5#P00336;Dopamine receptor mediated signaling pathway#P05912>CDK5#P05951;Nicotine pharmacodynamics pathway#P06587>CDK5#P06597;PDGF signaling pathway#P00047>GSK3#P01153;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902 HELRO|EnsemblGenome=HelroG171297|UniProtKB=T1F418 T1F418 20203567 PTHR15698:SF4 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG84829|UniProtKB=T1G5P3 T1G5P3 20216390 PTHR12638:SF0 PROTEIN MAGO NASHI HOMOLOG MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;gene expression#GO:0010467;RNA processing#GO:0006396;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;nuclear mRNA surveillance#GO:0071028;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exon-exon junction complex#GO:0035145;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG87582|UniProtKB=T1G6S5 T1G6S5 20216772 PTHR24393:SF190 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162488|UniProtKB=T1ESQ7 T1ESQ7 20199607 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG74970|UniProtKB=T1G1Y8 T1G1Y8 20215086 PTHR45694:SF30 GLUTAREDOXIN 2 GLUTAREDOXIN-2, MITOCHONDRIAL disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG163815|UniProtKB=T1EUI2 T1EUI2 20200232 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173374|UniProtKB=T1F6Q8 T1F6Q8 20204507 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 FGF signaling pathway#P00021>RKIP#P00630;EGF receptor signaling pathway#P00018>RKIP#P00548 HELRO|EnsemblGenome=HelroG155684|UniProtKB=T1ELK4 T1ELK4 20197454 PTHR24073:SF1240 DRAB5-RELATED RAS-RELATED PROTEIN RAB5 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;endocytosis#GO:0006897;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular localization#GO:0051641;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG106532|UniProtKB=T1EE32 T1EE32 20194834 PTHR43691:SF11 URIDINE PHOSPHORYLASE FI09636P-RELATED cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 Salvage pyrimidine ribonucleotides#P02775>Uridine phosphorylase#P03152 HELRO|EnsemblGenome=HelroG151243|UniProtKB=T1EKJ2 T1EKJ2 20197092 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG83315|UniProtKB=T1G541 T1G541 20216189 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165474|UniProtKB=T1EWV4 T1EWV4 20201054 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG80555|UniProtKB=T1G420 T1G420 20215818 PTHR31410:SF2 TRANSMEMBRANE PROTEIN 246 SUBFAMILY NOT NAMED glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG179326|UniProtKB=T1FEJ9 T1FEJ9 20207248 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG91542|UniProtKB=T1G852 T1G852 20217249 PTHR47219:SF9 RAB GTPASE-ACTIVATING PROTEIN 1-LIKE GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;binding#GO:0005488;enzyme binding#GO:0019899;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG79366|UniProtKB=T1G3N2 T1G3N2 20215680 PTHR11472:SF34 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER REGULATOR OF TELOMERE ELONGATION HELICASE 1 nucleoside phosphate binding#GO:1901265;binding#GO:0005488;ATP binding#GO:0005524;ATP-dependent activity#GO:0140657;enzyme binding#GO:0019899;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;nucleic acid conformation isomerase activity#GO:0120545;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;nucleotide binding#GO:0000166;isomerase activity#GO:0016853 regulation of double-strand break repair#GO:2000779;telomere organization#GO:0032200;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;negative regulation of DNA recombination#GO:0045910;negative regulation of cellular component organization#GO:0051129;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;regulation of telomere maintenance#GO:0032204;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;regulation of response to stress#GO:0080134;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular response to stress#GO:0080135;regulation of DNA recombination#GO:0000018;regulation of double-strand break repair via homologous recombination#GO:0010569;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;organelle organization#GO:0006996;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG64912|UniProtKB=T1FY11 T1FY11 20213709 PTHR10966:SF0 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488 transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG159998|UniProtKB=T1EPN0 T1EPN0 20198530 PTHR28617:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77 structural protein#PC00211 HELRO|EnsemblGenome=HelroG91356|UniProtKB=T1G829 T1G829 20217226 PTHR31134:SF1 TRANSMEMBRANE PROTEIN 128 TRANSMEMBRANE PROTEIN 128 HELRO|EnsemblGenome=HelroG64434|UniProtKB=T1FXU7 T1FXU7 20213645 PTHR24343:SF299 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190584|UniProtKB=T1FS42 T1FS42 20211639 PTHR11157:SF17 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 6 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG173159|UniProtKB=T1F6H1 T1F6H1 20204420 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70208|UniProtKB=T1G033 T1G033 20214431 PTHR12952:SF0 SYS1 PROTEIN SYS1 HOMOLOG localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;Golgi to endosome transport#GO:0006895;protein localization to organelle#GO:0033365;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;protein localization to cell periphery#GO:1990778;protein localization to Golgi apparatus#GO:0034067;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165507|UniProtKB=T1EWX9 T1EWX9 20201079 PTHR46473:SF30 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;transmembrane transporter binding#GO:0044325;channel activity#GO:0015267;channel regulator activity#GO:0016247;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;molecular function activator activity#GO:0140677;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 HELRO|EnsemblGenome=HelroG156562|UniProtKB=T1ELY2 T1ELY2 20197582 PTHR36983:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 13 DNAJ HOMOLOG SUBFAMILY C MEMBER 13 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 chaperone#PC00072 HELRO|EnsemblGenome=HelroG163252|UniProtKB=T1ETU4 T1ETU4 20199994 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175100|UniProtKB=T1F8U7 T1F8U7 20205246 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116840|UniProtKB=T1EGI3 T1EGI3 20195685 PTHR11884:SF2 SELECTIN LIGAND RELATED GOLGI COMPLEX-LOCALIZED GLYCOPROTEIN 1, ISOFORM B endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG86099|UniProtKB=T1G672 T1G672 20216569 PTHR45969:SF69 RING ZINC FINGER PROTEIN-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 HELRO|EnsemblGenome=HelroG84266|UniProtKB=T1G5G7 T1G5G7 20216314 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED PROTEIN NSUN7 HELRO|EnsemblGenome=HelroG156884|UniProtKB=T1EM26 T1EM26 20197626 PTHR24070:SF462 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY SMALL MONOMERIC GTPASE hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of locomotion#GO:0040012;intracellular signaling cassette#GO:0141124;negative regulation of locomotion#GO:0040013;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;negative regulation of cell motility#GO:2000146;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906 HELRO|EnsemblGenome=HelroG186060|UniProtKB=T1FNM0 T1FNM0 20210417 PTHR23088:SF30 NITRILASE-RELATED OMEGA-AMIDASE NIT2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG110752|UniProtKB=T1EF51 T1EF51 20195203 PTHR46756:SF29 TRANSGELIN GAS2-LIKE PROTEIN PICKLED EGGS actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 intracellular protein localization#GO:0008104;actin filament organization#GO:0007015;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;protein localization to microtubule cytoskeleton#GO:0072698;actin filament-based process#GO:0030029;microtubule bundle formation#GO:0001578;regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;protein localization to cytoskeleton#GO:0044380;cellular component organization#GO:0016043;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;protein localization to organelle#GO:0033365 microtubule cytoskeleton#GO:0015630;actomyosin#GO:0042641;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;stress fiber#GO:0001725;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371;actin cytoskeleton#GO:0015629;microtubule end#GO:1990752;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;actin filament bundle#GO:0032432;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG71154|UniProtKB=T1G0H1 T1G0H1 20214569 PTHR46276:SF1 E3 UBIQUITIN-PROTEIN LIGASE UBR5 E3 UBIQUITIN-PROTEIN LIGASE UBR5 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;positive regulation of signaling#GO:0023056;protein modification by small protein conjugation or removal#GO:0070647;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein polyubiquitination#GO:0000209;positive regulation of canonical Wnt signaling pathway#GO:0090263;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 Hedgehog signaling pathway#P00025>Ubiquitin ligase#P00693 HELRO|EnsemblGenome=HelroG68327|UniProtKB=T1FZD0 T1FZD0 20214178 PTHR11324:SF1 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN interleukin superfamily#PC00128;cytokine#PC00083 HELRO|EnsemblGenome=HelroG154098|UniProtKB=T1ELD7 T1ELD7 20197387 PTHR13412:SF0 T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG T-CELL IMMUNOMODULATORY PROTEIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG73405|UniProtKB=T1G1D6 T1G1D6 20214884 PTHR23050:SF549 CALCIUM BINDING PROTEIN AT22559P calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;centriole replication#GO:0007099;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG181020|UniProtKB=T1FGJ4 T1FGJ4 20207943 PTHR13437:SF7 NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1 CXXC-TYPE DOMAIN-CONTAINING PROTEIN structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;nuclear transport#GO:0051169;intracellular transport#GO:0046907;nucleocytoplasmic transport#GO:0006913;transport#GO:0006810 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 transporter#PC00227 HELRO|EnsemblGenome=HelroG180337|UniProtKB=T1FFR9 T1FFR9 20207668 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG145643|UniProtKB=T1EJL5 T1EJL5 20196765 PTHR10281:SF106 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED IP06960P-RELATED endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG79698|UniProtKB=T1G3S3 T1G3S3 20215721 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160596|UniProtKB=T1EQG7 T1EQG7 20198817 PTHR11097:SF9 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP43 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;nuclear mRNA surveillance#GO:0071028;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;snRNA processing#GO:0016180;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;snRNA metabolic process#GO:0016073;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of metabolic process#GO:0009892;maturation of 5.8S rRNA#GO:0000460;mRNA metabolic process#GO:0016071;snRNA 3'-end processing#GO:0034472;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;ribosome biogenesis#GO:0042254 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG182688|UniProtKB=T1FIL2 T1FIL2 20208661 PTHR47027:SF30 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63958|UniProtKB=T1FXM8 T1FXM8 20213576 PTHR15454:SF35 NISCHARIN RELATED NISCHARIN intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Rac protein signal transduction#GO:0016601 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159395|UniProtKB=T1ENZ9 T1ENZ9 20198299 PTHR45960:SF2 GRB2-ASSOCIATED-BINDING PROTEIN PROTEIN DAUGHTER OF SEVENLESS scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HELRO|EnsemblGenome=HelroG183954|UniProtKB=T1FKC5 T1FKC5 20209274 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR TITIN tyrosine protein kinase receptor#PC00233;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185969|UniProtKB=T1FNH9 T1FNH9 20210376 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216 chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG158735|UniProtKB=T1EN64 T1EN64 20198014 PTHR21215:SF0 LD36024P LD36024P HELRO|EnsemblGenome=HelroG83543|UniProtKB=T1G569 T1G569 20216217 PTHR12532:SF12 TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1 TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1 positive regulation of protein metabolic process#GO:0051247;positive regulation of translation#GO:0045727;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG189510|UniProtKB=T1FR41 T1FR41 20211288 PTHR14543:SF2 PROTRUDIN PROTRUDIN vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;transport#GO:0006810;endoplasmic reticulum tubular network organization#GO:0071786;cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;endoplasmic reticulum organization#GO:0007029;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum tubular network#GO:0071782 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG84246|UniProtKB=T1G5G3 T1G5G3 20216310 PTHR12965:SF0 VACUOLAR PROTEIN SORTING 54 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54 SNARE binding#GO:0000149;binding#GO:0005488;protein binding#GO:0005515;syntaxin binding#GO:0019905 vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization within membrane#GO:0051668;transport#GO:0006810;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74695|UniProtKB=T1G1U4 T1G1U4 20215042 PTHR20855:SF3 ADIPOR/PROGESTIN RECEPTOR-RELATED LD03007P transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG66045|UniProtKB=T1FYG2 T1FYG2 20213860 PTHR14003:SF37 TRANSCRIPTIONAL REPRESSOR PROTEIN YY YY2 TRANSCRIPTION FACTOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 chromosome#GO:0005694;PcG protein complex#GO:0031519;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG175932|UniProtKB=T1F9X3 T1F9X3 20205622 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;DNA exonuclease activity#GO:0004529;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;DNA endonuclease activity#GO:0004520;exonuclease activity#GO:0004527;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG156388|UniProtKB=T1ELV1 T1ELV1 20197551 PTHR11937:SF596 ACTIN BRAHMA ASSOCIATED PROTEIN 55KD structural molecule activity#GO:0005198;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;chromatin binding#GO:0003682 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;ATPase complex#GO:1904949;NuA4 histone acetyltransferase complex#GO:0035267;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG173491|UniProtKB=T1F6V9 T1F6V9 20204558 PTHR19957:SF307 SYNTAXIN SYNTAXIN-1A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 cellular component organization#GO:0016043;export from cell#GO:0140352;vesicle fusion#GO:0006906;protein transport#GO:0015031;secretion by cell#GO:0032940;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;exocytosis#GO:0006887;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066 HELRO|EnsemblGenome=HelroG194477|UniProtKB=T1FW35 T1FW35 20213031 PTHR46100:SF4 IMP2'P USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190718|UniProtKB=T1FS84 T1FS84 20211681 PTHR24123:SF33 ANKYRIN REPEAT-CONTAINING ANKYRIN 2, ISOFORM U scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181315|UniProtKB=T1FGW0 T1FGW0 20208059 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159163|UniProtKB=T1ENP3 T1ENP3 20198193 PTHR12232:SF17 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 HELRO|EnsemblGenome=HelroG178964|UniProtKB=T1FDZ4 T1FDZ4 20207043 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191187|UniProtKB=T1FSQ3 T1FSQ3 20211850 PTHR10372:SF27 PLAKOPHILLIN-RELATED P120 CATENIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;adherens junction#GO:0005912;cell junction#GO:0030054 cytoskeletal protein#PC00085;intermediate filament#PC00129;intermediate filament binding protein#PC00130 HELRO|EnsemblGenome=HelroG189243|UniProtKB=T1FQV0 T1FQV0 20211197 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG129198|UniProtKB=T1EHR4 T1EHR4 20196114 PTHR45134:SF5 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG133578|UniProtKB=T1EI15 T1EI15 20196215 PTHR24416:SF489 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172525|UniProtKB=T1F5G6 T1F5G6 20204065 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG77403|UniProtKB=T1G2X1 T1G2X1 20215419 PTHR11908:SF168 XANTHINE DEHYDROGENASE XANTHINE DEHYDROGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Purine metabolism#P02769>Xanthine Oxidase#P03116;Adenine and hypoxanthine salvage pathway#P02723>Xanthine dehydrogenase#P02809 HELRO|EnsemblGenome=HelroG177004|UniProtKB=T1FB45 T1FB45 20206044 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG177161|UniProtKB=T1FBA6 T1FBA6 20206105 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG159201|UniProtKB=T1ENQ7 T1ENQ7 20198207 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG96485|UniProtKB=T1G9C4 T1G9C4 20217671 PTHR14167:SF92 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192415|UniProtKB=T1FTX9 T1FTX9 20212276 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174205|UniProtKB=T1F7S4 T1F7S4 20204873 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104183|UniProtKB=T1EDK2 T1EDK2 20194654 PTHR13817:SF73 TITIN FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG174303|UniProtKB=T1F7Z1 T1F7Z1 20204940 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194962|UniProtKB=T1FWL9 T1FWL9 20213214 PTHR21615:SF2 CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1 CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1 Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG192199|UniProtKB=T1FTP3 T1FTP3 20212190 PTHR31056:SF1 TRANSMEMBRANE PROTEIN 179B TRANSMEMBRANE PROTEIN 179B HELRO|EnsemblGenome=HelroG192383|UniProtKB=T1FTW1 T1FTW1 20212258 PTHR16484:SF17 PARTITIONING DEFECTIVE 3 RELATED BAZOOKA, ISOFORM B small molecule binding#GO:0036094;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167 establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of apical/basal cell polarity#GO:0035088;cell adhesion#GO:0007155;establishment or maintenance of bipolar cell polarity#GO:0061245;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010 apical part of cell#GO:0045177;apical junction complex#GO:0043296;adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;cell cortex#GO:0005938;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG84029|UniProtKB=T1G5D6 T1G5D6 20216283 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG109211|UniProtKB=T1EER3 T1EER3 20195065 PTHR11216:SF178 EH DOMAIN AT21416P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;organelle assembly#GO:0070925;endocytic recycling#GO:0032456;cell projection organization#GO:0030030;endocytosis#GO:0006897;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to plasma membrane#GO:0072659 bounding membrane of organelle#GO:0098588;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;recycling endosome#GO:0055037;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG120098|UniProtKB=T1EGP5 T1EGP5 20195745 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG72129|UniProtKB=T1G0W2 T1G0W2 20214710 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG183367|UniProtKB=T1FJI7 T1FJI7 20208986 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG164375|UniProtKB=T1EVC3 T1EVC3 20200523 PTHR10913:SF45 FOLLISTATIN-RELATED AGRIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG80550|UniProtKB=T1G419 T1G419 20215817 PTHR46306:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 9 BTB_POZ DOMAIN-CONTAINING PROTEIN 9 regulation of signaling#GO:0023051;rhythmic process#GO:0048511;circadian rhythm#GO:0007623;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG189478|UniProtKB=T1FR32 T1FR32 20211279 PTHR24104:SF47 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED THIN, ISOFORM C ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG193706|UniProtKB=T1FVA2 T1FVA2 20212748 PTHR43016:SF18 PRESEQUENCE PROTEASE PRESEQUENCE PROTEASE, MITOCHONDRIAL catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG181328|UniProtKB=T1FGW3 T1FGW3 20208062 PTHR10476:SF2 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1B-RELATED endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;endosome transport via multivesicular body sorting pathway#GO:0032509;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;late endosome to vacuole transport#GO:0045324 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG160995|UniProtKB=T1EQZ4 T1EQZ4 20198994 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156792|UniProtKB=T1EM12 T1EM12 20197612 PTHR11829:SF377 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG187263|UniProtKB=T1FP84 T1FP84 20210631 PTHR10678:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;proteasome complex#GO:0000502;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG192587|UniProtKB=T1FU38 T1FU38 20212334 PTHR16083:SF85 LEUCINE RICH REPEAT CONTAINING PROTEIN RH62264P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194518|UniProtKB=T1FW55 T1FW55 20213051 PTHR14217:SF1 INOSITOL-TETRAKISPHOSPHATE 1-KINASE INOSITOL-TETRAKISPHOSPHATE 1-KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75089|UniProtKB=T1G202 T1G202 20215100 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;symporter activity#GO:0015293;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;chloride transport#GO:0006821;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG87124|UniProtKB=T1G6M0 T1G6M0 20216717 PTHR10529:SF340 AP COMPLEX SUBUNIT MU CARMINE, ISOFORM A cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;Golgi to vacuole transport#GO:0006896;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;AP-type membrane coat adaptor complex#GO:0030119;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG190300|UniProtKB=T1FRV7 T1FRV7 20211554 PTHR48051:SF1 FAMILY NOT NAMED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG102998|UniProtKB=T1EDD5 T1EDD5 20194587 PTHR24075:SF5 SEC63 DOMAIN-CONTAINING U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185068|UniProtKB=T1FMC8 T1FMC8 20209977 PTHR11596:SF96 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE-RELATED phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG190616|UniProtKB=T1FS51 T1FS51 20211648 PTHR10459:SF108 DNA LIGASE POLY [ADP-RIBOSE] POLYMERASE TANKYRASE pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG173137|UniProtKB=T1F6F7 T1F6F7 20204406 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70010|UniProtKB=T1G015 T1G015 20214413 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 ligase#PC00142 HELRO|EnsemblGenome=HelroG156467|UniProtKB=T1ELX1 T1ELX1 20197571 PTHR43289:SF6 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED SERINE_THREONINE KINASE 31 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG177859|UniProtKB=T1FCD6 T1FCD6 20206485 PTHR20961:SF167 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG186191|UniProtKB=T1FNS7 T1FNS7 20210474 PTHR10501:SF13 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;snRNA binding#GO:0017069 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 mRNA splicing#P00058>U2#P01478;mRNA splicing#P00058>U1#P01479 HELRO|EnsemblGenome=HelroG160031|UniProtKB=T1EPP2 T1EPP2 20198542 PTHR24104:SF50 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED NHL DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186278|UniProtKB=T1FNW7 T1FNW7 20210514 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HELRO|EnsemblGenome=HelroG81275|UniProtKB=T1G4C4 T1G4C4 20215922 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG75793|UniProtKB=T1G2A3 T1G2A3 20215201 PTHR10983:SF73 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG144094|UniProtKB=T1EJD6 T1EJD6 20196686 PTHR45695:SF9 LEUCOKININ RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG121337|UniProtKB=T1EGR4 T1EGR4 20195764 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;action potential#GO:0001508;metal ion transport#GO:0030001 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG174216|UniProtKB=T1F7T5 T1F7T5 20204884 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG70316|UniProtKB=T1G045 T1G045 20214443 PTHR13976:SF76 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED AT27789P ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG188308|UniProtKB=T1FPU9 T1FPU9 20210846 PTHR24058:SF135 DUAL SPECIFICITY PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166546|UniProtKB=T1EY83 T1EY83 20201533 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG189096|UniProtKB=T1FQM8 T1FQM8 20211125 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG81990|UniProtKB=T1G4L4 T1G4L4 20216012 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190347|UniProtKB=T1FRX4 T1FRX4 20211571 PTHR14379:SF93 LIMKAIN B LKAP MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1 binding#GO:0005488;protein-containing complex binding#GO:0044877 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169276|UniProtKB=T1F1P5 T1F1P5 20202745 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG165468|UniProtKB=T1EWU9 T1EWU9 20201049 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178636|UniProtKB=T1FDH3 T1FDH3 20206872 PTHR15934:SF2 RNA 2',3'-CYCLIC PHOSPHODIESTERASE A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG111078|UniProtKB=T1EF77 T1EF77 20195229 PTHR43530:SF1 QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1 QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1 glycosyltransferase activity#GO:0016757;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pentosyltransferase activity#GO:0016763 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185524|UniProtKB=T1FMX6 T1FMX6 20210175 PTHR45644:SF88 AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED FI08533P-RELATED establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;localization within membrane#GO:0051668;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150 HELRO|EnsemblGenome=HelroG191144|UniProtKB=T1FSN2 T1FSN2 20211829 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG64432|UniProtKB=T1FXU6 T1FXU6 20213644 PTHR14167:SF76 SH3 DOMAIN-CONTAINING ENDOPHILIN B, ISOFORM A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163501|UniProtKB=T1EU50 T1EU50 20200100 PTHR22932:SF1 TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE CYTOSOLIC PROSTAGLANDIN E SYNTHASE protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein folding#GO:0006457;chaperone-mediated protein complex assembly#GO:0051131;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184487|UniProtKB=T1FLA9 T1FLA9 20209608 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176946|UniProtKB=T1FB23 T1FB23 20206022 PTHR45929:SF3 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;macromolecule localization#GO:0033036;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;localization#GO:0051179;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;endosomal transport#GO:0016197;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;cellular localization#GO:0051641;protein transport#GO:0015031;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;vesicle#GO:0031982;intracellular vesicle#GO:0097708 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161898|UniProtKB=T1ES06 T1ES06 20199356 PTHR34209:SF1 RHODANESE/CELL CYCLE CONTROL PHOSPHATASE SUPERFAMILY PROTEIN CALCIUM SENSING RECEPTOR, CHLOROPLASTIC protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG184069|UniProtKB=T1FKI8 T1FKI8 20209337 PTHR24356:SF438 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE GREATWALL protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of mitotic cell cycle#GO:0007346;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG81871|UniProtKB=T1G4J9 T1G4J9 20215997 PTHR15458:SF5 PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;N-methyltransferase activity#GO:0008170 organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;phosphatidylcholine biosynthetic process#GO:0006656;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG83504|UniProtKB=T1G564 T1G564 20216212 PTHR12086:SF11 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2 anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;regulation of cellular component organization#GO:0051128;regulation of dendrite development#GO:0050773;regulation of cellular process#GO:0050794;synapse assembly#GO:0007416;cell junction organization#GO:0034330;regulation of developmental process#GO:0050793;cell junction assembly#GO:0034329;regulation of dendrite morphogenesis#GO:0048814;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental growth#GO:0048589;regulation of anatomical structure morphogenesis#GO:0022603;neuromuscular junction development#GO:0007528;regulation of cell projection organization#GO:0031344;developmental process#GO:0032502;growth#GO:0040007;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG165134|UniProtKB=T1EWB7 T1EWB7 20200867 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160914|UniProtKB=T1EQU7 T1EQU7 20198947 PTHR24119:SF10 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 SH2 DOMAIN-CONTAINING PROTEIN enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG121963|UniProtKB=T1EGT4 T1EGT4 20195784 PTHR10151:SF120 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE BIS(5'-ADENOSYL)-TRIPHOSPHATASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG192150|UniProtKB=T1FTM8 T1FTM8 20212175 PTHR23303:SF14 CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING BOS COMPLEX SUBUNIT NOMO1-RELATED endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HELRO|EnsemblGenome=HelroG168419|UniProtKB=T1F0K5 T1F0K5 20202355 PTHR44305:SF24 SI:DKEY-192D15.2-RELATED TYROSINE-PROTEIN KINASE C03B1.5-RELATED HELRO|EnsemblGenome=HelroG185333|UniProtKB=T1FMP3 T1FMP3 20210092 PTHR11071:SF581 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG176604|UniProtKB=T1FAQ0 T1FAQ0 20205899 PTHR43670:SF100 HEAT SHOCK PROTEIN 26 GROUND-LIKE DOMAIN-CONTAINING PROTEIN response to temperature stimulus#GO:0009266;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;cellular response to heat#GO:0034605;response to heat#GO:0009408;cellular response to stress#GO:0033554 chaperone#PC00072 HELRO|EnsemblGenome=HelroG101910|UniProtKB=T1ED74 T1ED74 20194526 PTHR21294:SF8 ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG177225|UniProtKB=T1FBD6 T1FBD6 20206135 PTHR43903:SF28 NEUROLIGIN FI18641P1 protein binding#GO:0005515;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;nervous system development#GO:0007399;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;membrane assembly#GO:0071709;endocytosis#GO:0006897;synapse assembly#GO:0007416;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;cellular localization#GO:0051641;synaptic vesicle recycling#GO:0036465;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;membrane organization#GO:0061024;developmental process#GO:0032502;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;synaptic vesicle endocytosis#GO:0048488;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;postsynapse organization#GO:0099173;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;cell communication#GO:0007154;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731 membrane#GO:0016020;cell periphery#GO:0071944;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell surface#GO:0009986;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG187932|UniProtKB=T1FPH4 T1FPH4 20210721 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG177490|UniProtKB=T1FBS3 T1FBS3 20206272 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG157306|UniProtKB=T1EM92 T1EM92 20197692 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG74511|UniProtKB=T1G1S1 T1G1S1 20215019 PTHR10231:SF106 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-GALACTOSE TRANSLOCATOR nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;UDP-galactose transmembrane transporter activity#GO:0005459;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;nucleotide-sugar transmembrane transport#GO:0015780;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG166004|UniProtKB=T1EXK6 T1EXK6 20201306 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG94435|UniProtKB=T1G913 T1G913 20217560 PTHR10383:SF9 SERINE INCORPORATOR SERINE INCORPORATOR, ISOFORM F cellular anatomical structure#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG174351|UniProtKB=T1F813 T1F813 20204962 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70692|UniProtKB=T1G0A8 T1G0A8 20214506 PTHR13767:SF2 TRNA-PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE TRUB1 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 mRNA modification#GO:0016556;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG62222|UniProtKB=T1FWX2 T1FWX2 20213320 PTHR12268:SF14 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROPHIN-1 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155469|UniProtKB=T1ELI4 T1ELI4 20197434 PTHR11850:SF266 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN HOMOTHORAX sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 embryonic pattern specification#GO:0009880;sensory system development#GO:0048880;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of cell population proliferation#GO:0008284;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;eye development#GO:0001654;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;pattern specification process#GO:0007389;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG174240|UniProtKB=T1F7V1 T1F7V1 20204900 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG185545|UniProtKB=T1FMY8 T1FMY8 20210187 PTHR11085:SF19 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 acyltransferase activity#GO:0016746;transcription regulator activity#GO:0140110;deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;transcription coregulator activity#GO:0003712;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;transcription corepressor activity#GO:0003714;deacylase activity#GO:0160215;transferase activity#GO:0016740;NAD-dependent protein lysine deacetylase activity#GO:0034979;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG187365|UniProtKB=T1FP93 T1FP93 20210640 PTHR45624:SF63 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL ORNITHINE TRANSPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;intracellular transport#GO:0046907;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;mitochondrial transmembrane transport#GO:1990542;cellular localization#GO:0051641;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG84740|UniProtKB=T1G5N0 T1G5N0 20216377 PTHR42884:SF38 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein processing#GO:0016485;peptide hormone processing#GO:0016486;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007;proteolysis#GO:0006508;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;DPP signaling pathway#P06213>FUR1#P06290;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Activin beta signaling pathway#P06210>FUR1#P06238;DPP-SCW signaling pathway#P06212>FUR1#P06263;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;Endothelin signaling pathway#P00019>furin#P00575;MYO signaling pathway#P06215>FUR1#P06318;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG159202|UniProtKB=T1ENQ8 T1ENQ8 20198208 PTHR13063:SF10 ENOS INTERACTING PROTEIN NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG72919|UniProtKB=T1G172 T1G172 20214820 PTHR11006:SF10 PROTEIN ARGININE N-METHYLTRANSFERASE HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177574|UniProtKB=T1FBW1 T1FBW1 20206310 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN binding#GO:0005488;hormone binding#GO:0042562;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG110322|UniProtKB=T1EF14 T1EF14 20195166 PTHR24343:SF348 SERINE/THREONINE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283;gamete generation#GO:0007276;cell differentiation#GO:0030154;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182955|UniProtKB=T1FIZ5 T1FIZ5 20208794 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;poly(A) binding#GO:0008143;nucleic acid binding#GO:0003676 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG68515|UniProtKB=T1FZG2 T1FZG2 20214210 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG67681|UniProtKB=T1FZ37 T1FZ37 20214085 PTHR14942:SF21 U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG162447|UniProtKB=T1ESN9 T1ESN9 20199589 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65123|UniProtKB=T1FY34 T1FY34 20213732 PTHR24180:SF58 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 49 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 kinase inhibitor#PC00139;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG178635|UniProtKB=T1FDH2 T1FDH2 20206871 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG113832|UniProtKB=T1EFX2 T1EFX2 20195474 PTHR14140:SF45 E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;post-translational protein modification#GO:0043687;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;protein modification by small protein conjugation or removal#GO:0070647;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;metabolic process#GO:0008152;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG141893|UniProtKB=T1EJ45 T1EJ45 20196595 PTHR12570:SF92 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED SPICHTHYIN, ISOFORM B magnesium ion transport#GO:0015693;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG174878|UniProtKB=T1F8K4 T1F8K4 20205153 PTHR15510:SF5 SPERM-ASSOCIATED ANTIGEN 8 SPERM-ASSOCIATED ANTIGEN 8 reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;sperm motility#GO:0097722;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;flagellated sperm motility#GO:0030317 axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG180021|UniProtKB=T1FFC9 T1FFC9 20207528 PTHR24248:SF215 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 84 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG178905|UniProtKB=T1FDV8 T1FDV8 20207007 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG159895|UniProtKB=T1EPI5 T1EPI5 20198485 PTHR24178:SF52 MOLTING PROTEIN MLT-4 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;localization#GO:0051179 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG184963|UniProtKB=T1FM76 T1FM76 20209925 PTHR43372:SF4 FATTY-ACID AMIDE HYDROLASE FATTY-ACID AMIDE HYDROLASE 2 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG112159|UniProtKB=T1EFH4 T1EFH4 20195326 PTHR43201:SF8 ACYL-COA SYNTHETASE ACYL-COA SYNTHETASE FAMILY MEMBER 3 ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG88112|UniProtKB=T1G6Y6 T1G6Y6 20216833 PTHR10336:SF159 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787;lipase activity#GO:0016298 phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;transport#GO:0006810;establishment of localization#GO:0051234;organophosphate metabolic process#GO:0019637;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;metabolic process#GO:0008152;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;leading edge membrane#GO:0031256;ruffle membrane#GO:0032587;ruffle#GO:0001726;cell projection membrane#GO:0031253 phospholipase#PC00186;metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 EGF receptor signaling pathway#P00018>PLCgamma#P00556;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;PDGF signaling pathway#P00047>PLCgamma#P01171;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;VEGF signaling pathway#P00056>PLC-gamma#P01414;FGF signaling pathway#P00021>PLCgamma#P00638;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Angiogenesis#P00005>PLC-gamma#P00256;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Axon guidance mediated by netrin#P00009>Phospholipase C#P00362 HELRO|EnsemblGenome=HelroG116604|UniProtKB=T1EGG4 T1EGG4 20195666 PTHR24006:SF952 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG172433|UniProtKB=T1F5B7 T1F5B7 20204016 PTHR11850:SF421 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX DOMAIN-CONTAINING PROTEIN helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG95543|UniProtKB=T1G967 T1G967 20217614 PTHR14136:SF17 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9 HELRO|EnsemblGenome=HelroG135395|UniProtKB=T1EI86 T1EI86 20196286 PTHR12932:SF9 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;positive regulation of protein polymerization#GO:0032273;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;positive regulation of cellular component organization#GO:0051130;microtubule bundle formation#GO:0001578;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG187510|UniProtKB=T1FPA3 T1FPA3 20210650 PTHR12174:SF23 SIGNAL PEPTIDE PEPTIDASE SIGNAL PEPTIDE PEPTIDASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;cytoplasmic side of membrane#GO:0098562;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 protein modifying enzyme#PC00260;aspartic protease#PC00053 HELRO|EnsemblGenome=HelroG185662|UniProtKB=T1FN39 T1FN39 20210237 PTHR11224:SF10 MAKORIN-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG115162|UniProtKB=T1EG68 T1EG68 20195570 PTHR10856:SF0 CORONIN CORONIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG192588|UniProtKB=T1FU39 T1FU39 20212335 PTHR45812:SF1 DNA POLYMERASE ZETA CATALYTIC SUBUNIT DNA POLYMERASE ZETA CATALYTIC SUBUNIT DNA-directed DNA polymerase activity#GO:0003887;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA damage tolerance#GO:0006301;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;translesion synthesis#GO:0019985;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA synthesis involved in DNA replication#GO:0090592;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG67729|UniProtKB=T1FZ46 T1FZ46 20214094 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804 postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG82245|UniProtKB=T1G4P6 T1G4P6 20216044 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG154764|UniProtKB=T1ELG0 T1ELG0 20197410 PTHR13691:SF16 RIBOSOMAL PROTEIN L2 LARGE RIBOSOMAL SUBUNIT PROTEIN UL2 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG147750|UniProtKB=T1EK26 T1EK26 20196926 PTHR47163:SF4 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN ISXO2-LIKE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192159|UniProtKB=T1FTN0 T1FTN0 20212177 PTHR44027:SF8 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051 synapse#GO:0045202;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection terminus#GO:0044306;neuron projection#GO:0043005;presynapse#GO:0098793;cell junction#GO:0030054;axon terminus#GO:0043679;axon#GO:0030424 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184494|UniProtKB=T1FLB5 T1FLB5 20209614 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG142631|UniProtKB=T1EJ64 T1EJ64 20196614 PTHR22961:SF13 SER/THR PROTEIN KINASE-TRB TRIBBLES enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;biological regulation#GO:0065007;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of ubiquitin-dependent protein catabolic process#GO:2000058 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG68968|UniProtKB=T1FZM7 T1FZM7 20214275 PTHR10026:SF144 CYCLIN CYCLIN-K kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357 organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911 kinase modulator#PC00140;kinase activator#PC00138 Cell cycle#P00013>CdkC#P00489 HELRO|EnsemblGenome=HelroG186106|UniProtKB=T1FNN6 T1FNN6 20210433 PTHR13120:SF0 PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2 snRNP#GO:0005686;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG83772|UniProtKB=T1G5A0 T1G5A0 20216247 PTHR24205:SF16 FOUR AND A HALF LIM DOMAINS PROTEIN GH01042P-RELATED transcription cofactor#PC00217 Angiogenesis#P00005>Paxillin#P00194;VEGF signaling pathway#P00056>Paxillin#P01418 HELRO|EnsemblGenome=HelroG172602|UniProtKB=T1F5L5 T1F5L5 20204114 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG117034|UniProtKB=T1EGJ5 T1EGJ5 20195697 PTHR19441:SF95 WAP four-disulfide core domain protein ANTISTASIN-LIKE DOMAIN-CONTAINING PROTEIN endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG159143|UniProtKB=T1ENN5 T1ENN5 20198185 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175648|UniProtKB=T1F9H0 T1F9H0 20205469 PTHR10269:SF12 GDNF RECEPTOR ALPHA GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system development#GO:0048731;nervous system development#GO:0007399;multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 side of membrane#GO:0098552;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175376|UniProtKB=T1F976 T1F976 20205375 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192336|UniProtKB=T1FTU2 T1FTU2 20212239 PTHR24044:SF417 NOTCH LIGAND FAMILY MEMBER WEARY, ISOFORM B signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG183617|UniProtKB=T1FJX9 T1FJX9 20209128 PTHR34153:SF3 SI:CH211-262H13.3-RELATED-RELATED SI:CH211-262H13.3 HELRO|EnsemblGenome=HelroG101144|UniProtKB=T1ED32 T1ED32 20194484 PTHR46203:SF1 PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65 MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 translation release factor#PC00225 HELRO|EnsemblGenome=HelroG165749|UniProtKB=T1EX89 T1EX89 20201189 PTHR47027:SF32 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160132|UniProtKB=T1EPU7 T1EPU7 20198597 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG187371|UniProtKB=T1FP95 T1FP95 20210642 PTHR11468:SF13 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 glycogen metabolic process#GO:0005977;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;polysaccharide catabolic process#GO:0000272;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976;carbohydrate metabolic process#GO:0005975;glucan catabolic process#GO:0009251;energy reserve metabolic process#GO:0006112;carbohydrate catabolic process#GO:0016052;glycogen catabolic process#GO:0005980;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;generation of precursor metabolites and energy#GO:0006091;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG167194|UniProtKB=T1EZ46 T1EZ46 20201846 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177651|UniProtKB=T1FC07 T1FC07 20206356 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189835|UniProtKB=T1FRE6 T1FRE6 20211393 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG121581|UniProtKB=T1EGS4 T1EGS4 20195774 PTHR24247:SF222 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 2B, ISOFORM E G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 dendrite#GO:0030425;dendritic tree#GO:0097447;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG163200|UniProtKB=T1ETS5 T1ETS5 20199975 PTHR23050:SF536 CALCIUM BINDING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG72621|UniProtKB=T1G127 T1G127 20214775 PTHR11956:SF5 ARGINYL-TRNA SYNTHETASE ARGININE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG153267|UniProtKB=T1EL23 T1EL23 20197273 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172398|UniProtKB=T1F596 T1F596 20203995 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG185418|UniProtKB=T1FMS8 T1FMS8 20210127 PTHR47979:SF53 DRAB11-RELATED FI07418P ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 cellular process#GO:0009987;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG132487|UniProtKB=T1EHY8 T1EHY8 20196188 PTHR11097:SF14 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP45 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;ribosome biogenesis#GO:0042254;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biological process#GO:0050789;ribonucleoprotein complex biogenesis#GO:0022613;snRNA 3'-end processing#GO:0034472;negative regulation of metabolic process#GO:0009892;maturation of 5.8S rRNA#GO:0000460;mRNA metabolic process#GO:0016071;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;snRNA processing#GO:0016180;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;nuclear mRNA surveillance#GO:0071028;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;snRNA metabolic process#GO:0016073;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG76772|UniProtKB=T1G2P3 T1G2P3 20215341 PTHR11006:SF124 PROTEIN ARGININE N-METHYLTRANSFERASE ARGININE METHYLTRANSFERASE 9-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;histone modifying activity#GO:0140993;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054 regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73194|UniProtKB=T1G1B6 T1G1B6 20214864 PTHR12964:SF0 NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6 oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179263|UniProtKB=T1FEG3 T1FEG3 20207212 PTHR24260:SF149 AT07769P-RELATED AT07769P-RELATED HELRO|EnsemblGenome=HelroG73503|UniProtKB=T1G1E8 T1G1E8 20214896 PTHR12292:SF9 RWD DOMAIN-CONTAINING PROTEIN RWD DOMAIN-CONTAINING PROTEIN 1 biological regulation#GO:0065007;response to chemical#GO:0042221;nuclear receptor-mediated signaling pathway#GO:0141193;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;signal transduction#GO:0007165;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;cellular process#GO:0009987;response to hormone#GO:0009725;cellular response to steroid hormone stimulus#GO:0071383;intracellular receptor signaling pathway#GO:0030522;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;steroid hormone receptor signaling pathway#GO:0043401;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;response to steroid hormone#GO:0048545 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185044|UniProtKB=T1FMB7 T1FMB7 20209966 PTHR44145:SF5 DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL DNAJ HOMOLOG L(2)TID, MITOCHONDRIAL cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184266|UniProtKB=T1FKV7 T1FKV7 20209456 PTHR37162:SF15 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154625|UniProtKB=T1ELF3 T1ELF3 20197403 PTHR10210:SF130 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189218|UniProtKB=T1FQT2 T1FQT2 20211179 PTHR23322:SF6 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 7 ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171677|UniProtKB=T1F4J4 T1F4J4 20203743 PTHR43939:SF128 COILED-COIL DOMAIN-CONTAINING PROTEIN 158 ASTERLESS protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093;protein-membrane adaptor activity#GO:0043495 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;microtubule organizing center organization#GO:0031023;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of organelle localization#GO:0051656;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cellular localization#GO:0051641;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG188882|UniProtKB=T1FQF5 T1FQF5 20211052 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG173940|UniProtKB=T1F7E4 T1F7E4 20204743 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;establishment of organelle localization#GO:0051656;cellular localization#GO:0051641;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;chromatin organization#GO:0006325;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;organelle localization#GO:0051640;localization#GO:0051179 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HELRO|EnsemblGenome=HelroG111854|UniProtKB=T1EFF1 T1EFF1 20195303 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG182763|UniProtKB=T1FIP5 T1FIP5 20208694 PTHR13817:SF73 TITIN FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG92767|UniProtKB=T1G8K6 T1G8K6 20217403 PTHR45712:SF36 AGAP008170-PA PODOCAN ISOFORM X1 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG184275|UniProtKB=T1FKW5 T1FKW5 20209464 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG62071|UniProtKB=T1FWV2 T1FWV2 20213300 PTHR10937:SF0 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING) catalytic activity#GO:0003824;transferase activity#GO:0016740;transaminase activity#GO:0008483 UDP-N-acetylglucosamine metabolic process#GO:0006047;organophosphate biosynthetic process#GO:0090407;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-sugar metabolic process#GO:0009225;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 transaminase#PC00216 O-antigen biosynthesis#P02757>Fructose-6-phosphate aminotransferase#P03051;N-acetylglucosamine metabolism#P02756>Fructose-6-phosphate aminotransferase#P03042 HELRO|EnsemblGenome=HelroG189270|UniProtKB=T1FQW4 T1FQW4 20211211 PTHR46378:SF1 STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN regulation of biosynthetic process#GO:0009889;regulation of steroid biosynthetic process#GO:0050810;regulation of lipid biosynthetic process#GO:0046890;SREBP signaling pathway#GO:0032933;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of lipid metabolic process#GO:0019216;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG165437|UniProtKB=T1EWS6 T1EWS6 20201026 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65487|UniProtKB=T1FY85 T1FY85 20213783 PTHR13040:SF2 AUTOPHAGY PROTEIN 5 AUTOPHAGY PROTEIN 5 aminoacyltransferase activity#GO:0016755;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;response to starvation#GO:0042594;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;autophagy of mitochondrion#GO:0000422;cellular response to nutrient levels#GO:0031669;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987 transferase complex#GO:1990234;phagophore assembly site#GO:0000407;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG157135|UniProtKB=T1EM70 T1EM70 20197670 PTHR42854:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED tRNA binding#GO:0000049;translation initiation factor activity#GO:0003743;RNA binding#GO:0003723;translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translational initiation#GO:0002183;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG184959|UniProtKB=T1FM74 T1FM74 20209923 PTHR11276:SF42 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA POLYMERASE BETA DNA-directed DNA polymerase activity#GO:0003887;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG71944|UniProtKB=T1G0T2 T1G0T2 20214680 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG189200|UniProtKB=T1FQS1 T1FQS1 20211168 PTHR10082:SF60 INTEGRIN BETA SUBUNIT INTEGRIN BETA-PS binding#GO:0005488;signaling receptor binding#GO:0005102;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178 cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052;cell adhesion mediated by integrin#GO:0033627;cell surface receptor signaling pathway#GO:0007166;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;cellular process#GO:0009987;cell migration#GO:0016477;biological regulation#GO:0065007 signaling receptor complex#GO:0043235;cell junction#GO:0030054;integrin complex#GO:0008305;anchoring junction#GO:0070161;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;focal adhesion#GO:0005925;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HELRO|EnsemblGenome=HelroG192146|UniProtKB=T1FTM6 T1FTM6 20212173 PTHR19324:SF33 PERFORIN-LIKE PROTEIN 1 MUCIN-5AC HELRO|EnsemblGenome=HelroG191387|UniProtKB=T1FSY2 T1FSY2 20211929 PTHR11093:SF6 RUVB-RELATED REPTIN AND PONTIN RUVB-LIKE 1 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545 ribonucleoprotein complex biogenesis#GO:0022613;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;protein-RNA complex assembly#GO:0022618;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular component assembly#GO:0022607;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;cellular component biogenesis#GO:0044085;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;protein-RNA complex organization#GO:0071826 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG158766|UniProtKB=T1EN85 T1EN85 20198035 PTHR11610:SF199 LIPASE PANCREATIC TRIACYLGLYCEROL LIPASE-LIKE ISOFORM X2 hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;lipid catabolic process#GO:0016042;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG171378|UniProtKB=T1F474 T1F474 20203623 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG111709|UniProtKB=T1EFE0 T1EFE0 20195292 PTHR24409:SF448 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG192855|UniProtKB=T1FUD2 T1FUD2 20212428 PTHR12365:SF7 SPROUTY PROTEIN SPROUTY kinase inhibitor activity#GO:0019210;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;protein kinase regulator activity#GO:0019887;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of Ras protein signal transduction#GO:0046578;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of MAPK cascade#GO:0043409;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 scaffold/adaptor protein#PC00226 FGF signaling pathway#P00021>Spry#P00626;EGF receptor signaling pathway#P00018>Spry#P00541;EGF receptor signaling pathway#P00018>SPRY#G01511 HELRO|EnsemblGenome=HelroG173534|UniProtKB=T1F6Y4 T1F6Y4 20204583 PTHR15666:SF1 COMM DOMAIN CONTAINING PROTEIN 5 COMM DOMAIN-CONTAINING PROTEIN 5 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 protein-containing complex#GO:0032991 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG170747|UniProtKB=T1F3D9 T1F3D9 20203338 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG182250|UniProtKB=T1FI00 T1FI00 20208449 PTHR15439:SF22 RETINOBLASTOMA-BINDING PROTEIN 6 DNA LIGASE (NAD(+)) protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG170497|UniProtKB=T1F347 T1F347 20203246 PTHR12195:SF6 CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED CYTOPLASMIC FMR1-INTERACTING PROTEIN neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;regulation of protein metabolic process#GO:0051246;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;axon guidance#GO:0007411;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556 neuron projection#GO:0043005;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG181736|UniProtKB=T1FH98 T1FH98 20208197 PTHR24115:SF194 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF6 protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG160693|UniProtKB=T1EQL9 T1EQL9 20198869 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG161829|UniProtKB=T1ERY4 T1ERY4 20199334 PTHR11595:SF92 EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER ELONGATION FACTOR 1-BETA guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;translational elongation#GO:0006414 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG193528|UniProtKB=T1FV32 T1FV32 20212678 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169764|UniProtKB=T1F2B1 T1F2B1 20202961 PTHR23167:SF96 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED ALPHA ACTININ 3-RELATED cellular process#GO:0009987;actin filament-based process#GO:0030029;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73126|UniProtKB=T1G1A5 T1G1A5 20214853 PTHR12689:SF4 A1 CISTRON SPLICING FACTOR AAR2-RELATED PROTEIN AAR2 HOMOLOG gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG163817|UniProtKB=T1EUI3 T1EUI3 20200233 PTHR20835:SF0 E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED E3 UBIQUITIN-PROTEIN LIGASE PPP1R11 phosphatase regulator activity#GO:0019208;protein phosphatase binding#GO:0019903;molecular function regulator activity#GO:0098772;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;protein phosphatase regulator activity#GO:0019888 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193071|UniProtKB=T1FUL4 T1FUL4 20212510 PTHR13547:SF23 RIBONUCLEASE P MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;ribonuclease P activity#GO:0004526;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;nuclease activity#GO:0004518 tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774 intracellular protein-containing complex#GO:0140535;endonuclease complex#GO:1905348;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;endoribonuclease complex#GO:1902555;ribonuclease P complex#GO:0030677;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG110518|UniProtKB=T1EF30 T1EF30 20195182 PTHR43381:SF20 TRANSLATION INITIATION FACTOR IF-2-RELATED TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG70650|UniProtKB=T1G098 T1G098 20214496 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG77746|UniProtKB=T1G333 T1G333 20215481 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183449|UniProtKB=T1FJP2 T1FJP2 20209041 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HB1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG155612|UniProtKB=T1ELJ7 T1ELJ7 20197447 PTHR23073:SF31 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 10B isomerase activity#GO:0016853;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription initiation#GO:2000142;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;response to endoplasmic reticulum stress#GO:0034976;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;ERAD pathway#GO:0036503;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;positive regulation of cellular component organization#GO:0051130;cellular response to stress#GO:0033554;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944 proteasome complex#GO:0000502;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG178719|UniProtKB=T1FDM5 T1FDM5 20206924 PTHR46169:SF15 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG160971|UniProtKB=T1EQX9 T1EQX9 20198979 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188640|UniProtKB=T1FQ75 T1FQ75 20210972 PTHR21625:SF1 NYD-SP28 PROTEIN DYNEIN REGULATORY COMPLEX PROTEIN 1 plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of microtubule-based movement#GO:0060632;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;cilium-dependent cell motility#GO:0060285;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium or flagellum-dependent cell motility#GO:0001539;regulation of microtubule-based process#GO:0032886;organelle assembly#GO:0070925 cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG151879|UniProtKB=T1EKM4 T1EKM4 20197124 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG156925|UniProtKB=T1EM33 T1EM33 20197633 PTHR12610:SF12 SINGLE STRANDED DNA BINDING PROTEIN SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG113471|UniProtKB=T1EFS7 T1EFS7 20195429 PTHR11550:SF47 CTP SYNTHASE CTP SYNTHASE 1-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;binding#GO:0005488;identical protein binding#GO:0042802;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515 small molecule metabolic process#GO:0044281;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribose phosphate biosynthetic process#GO:0046390;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;pyrimidine nucleobase metabolic process#GO:0006206;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;supramolecular fiber#GO:0099512;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 ligase#PC00142;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>CTP synthase#P02931 HELRO|EnsemblGenome=HelroG172749|UniProtKB=T1F5W6 T1F5W6 20204215 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84960|UniProtKB=T1G5R0 T1G5R0 20216407 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;metabolic process#GO:0008152;proteolysis#GO:0006508;catabolic process#GO:0009056;primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG186501|UniProtKB=T1FP03 T1FP03 20210550 PTHR11721:SF3 60S RIBOSOMAL PROTEIN L27A LARGE RIBOSOMAL SUBUNIT PROTEIN UL15 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG85912|UniProtKB=T1G642 T1G642 20216539 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824 catabolic process#GO:0009056;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG186126|UniProtKB=T1FNP6 T1FNP6 20210443 PTHR13718:SF4 RIBOSOMAL S SUBUNIT SMALL RIBOSOMAL SUBUNIT PROTEIN US5 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG148094|UniProtKB=T1EK46 T1EK46 20196946 PTHR24068:SF33 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG164388|UniProtKB=T1EVD1 T1EVD1 20200531 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG185629|UniProtKB=T1FN24 T1FN24 20210223 PTHR10971:SF2 MRNA EXPORT FACTOR AND BUB3 DYNEIN AXONEMAL ASSEMBLY FACTOR 10 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG172655|UniProtKB=T1F5Q7 T1F5Q7 20204156 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167440|UniProtKB=T1EZD8 T1EZD8 20201938 PTHR22605:SF26 RZ-TYPE DOMAIN-CONTAINING PROTEIN RZ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173888|UniProtKB=T1F7C2 T1F7C2 20204721 PTHR13159:SF0 RADIAL SPOKEHEAD-RELATED RADIAL SPOKE HEAD COMPONENT 4A cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;organelle assembly#GO:0070925;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG87546|UniProtKB=T1G6R9 T1G6R9 20216766 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG193928|UniProtKB=T1FVH4 T1FVH4 20212820 PTHR14388:SF17 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG134781|UniProtKB=T1EI58 T1EI58 20196258 PTHR24390:SF230 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 362 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG68930|UniProtKB=T1FZM1 T1FZM1 20214269 PTHR13357:SF1 SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN NCK-INTERACTING PROTEIN WITH SH3 DOMAIN protein-containing complex binding#GO:0044877;binding#GO:0005488 localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;endocytosis#GO:0006897;transport#GO:0006810 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166983|UniProtKB=T1EYU5 T1EYU5 20201745 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113658|UniProtKB=T1EFU7 T1EFU7 20195449 PTHR10160:SF19 NAD(P) TRANSHYDROGENASE NAD(P) TRANSHYDROGENASE, MITOCHONDRIAL nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;purine nucleotide binding#GO:0017076;binding#GO:0005488 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing small molecule metabolic process#GO:0055086 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG98264|UniProtKB=T1G9L5 T1G9L5 20217761 PTHR10314:SF194 CYSTATHIONINE BETA-SYNTHASE CYSTATHIONINE BETA-SYNTHASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 lyase#PC00144;metabolite interconversion enzyme#PC00262 Cysteine biosynthesis#P02737>O-Acetylserine-lyase#P02887 HELRO|EnsemblGenome=HelroG153366|UniProtKB=T1EL51 T1EL51 20197301 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG165370|UniProtKB=T1EWN5 T1EWN5 20200985 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188507|UniProtKB=T1FQ26 T1FQ26 20210923 PTHR21559:SF21 DYSTROGLYCAN-RELATED DYSTROGLYCAN 1 cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;system development#GO:0048731;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;plasma membrane bounded cell projection organization#GO:0120036;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;tissue development#GO:0009888;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039 membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;sarcolemma#GO:0042383 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG180511|UniProtKB=T1FG00 T1FG00 20207749 PTHR19211:SF14 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1 nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG95510|UniProtKB=T1G963 T1G963 20217610 PTHR10625:SF5 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE HDA1 deacylase activity#GO:0160215;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407;histone modifying activity#GO:0140993;catalytic activity, acting on a protein#GO:0140096;deacetylase activity#GO:0019213 epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG194872|UniProtKB=T1FWI3 T1FWI3 20213178 PTHR11089:SF30 GTP-BINDING PROTEIN-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG173520|UniProtKB=T1F6X5 T1F6X5 20204574 PTHR15021:SF0 DISCONNECTED-RELATED DISCO-RELATED, ISOFORM A-RELATED regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG79617|UniProtKB=T1G3R1 T1G3R1 20215709 PTHR31609:SF1 YDJC DEACETYLASE FAMILY MEMBER CARBOHYDRATE DEACETYLASE deacylase activity#GO:0160215;catalytic activity#GO:0003824;deacetylase activity#GO:0019213 HELRO|EnsemblGenome=HelroG192908|UniProtKB=T1FUF0 T1FUF0 20212446 PTHR46370:SF1 GPALPP MOTIFS-CONTAINING PROTEIN 1 GPALPP MOTIFS-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG145221|UniProtKB=T1EJJ3 T1EJJ3 20196743 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167922|UniProtKB=T1EZY8 T1EZY8 20202138 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H hydrolase activity#GO:0016787;nuclease activity#GO:0004518;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;mitochondrial DNA metabolic process#GO:0032042;DNA-templated DNA replication#GO:0006261;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG161791|UniProtKB=T1ERX2 T1ERX2 20199322 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188230|UniProtKB=T1FPS7 T1FPS7 20210824 PTHR16171:SF7 DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED XPG (XERODERMA PIGMENTOSUM GROUP G) DNA REPAIR GENE HOMOLOG DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleotide-excision repair complex#GO:0000109;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG68939|UniProtKB=T1FZM2 T1FZM2 20214270 PTHR45720:SF10 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 voltage-gated monoatomic anion channel activity#GO:0008308;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;channel activity#GO:0015267;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244 inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185172|UniProtKB=T1FMG8 T1FMG8 20210017 PTHR11588:SF462 TUBULIN TUBULIN ALPHA CHAIN nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell differentiation#GO:0030154;mitotic cell cycle#GO:0000278;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG63220|UniProtKB=T1FXC6 T1FXC6 20213474 PTHR21094:SF2 GOS-28 SNARE- RELATED GOLGI SNAP RECEPTOR COMPLEX MEMBER 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 localization#GO:0051179;cellular component organization#GO:0016043;intra-Golgi vesicle-mediated transport#GO:0006891;vesicle fusion#GO:0006906;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;Golgi stack#GO:0005795;membrane protein complex#GO:0098796 membrane traffic protein#PC00150;SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG106302|UniProtKB=T1EE16 T1EE16 20194818 PTHR19842:SF0 G BETA-LIKE PROTEIN GBL TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 regulation of actin filament-based process#GO:0032970;TOR signaling#GO:0031929;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;TOR complex#GO:0038201 HELRO|EnsemblGenome=HelroG105624|UniProtKB=T1EDW7 T1EDW7 20194769 PTHR10159:SF528 DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG164619|UniProtKB=T1EVN3 T1EVN3 20200633 PTHR24180:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN 39 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG184964|UniProtKB=T1FM77 T1FM77 20209926 PTHR13011:SF0 TFIIF-ALPHA GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1 RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;transcription factor binding#GO:0008134;binding#GO:0005488 macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIFalpha#P00663;Transcription regulation by bZIP transcription factor#P00055>TFIIFalpha#P01391 HELRO|EnsemblGenome=HelroG185809|UniProtKB=T1FNB5 T1FNB5 20210312 PTHR11581:SF0 30S/40S RIBOSOMAL PROTEIN S4 RIBOSOMAL PROTEIN S4 Y1-RELATED structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG185616|UniProtKB=T1FN16 T1FN16 20210215 PTHR10476:SF4 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 2A localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;late endosome to vacuole transport#GO:0045324;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG171098|UniProtKB=T1F3T2 T1F3T2 20203481 PTHR12287:SF23 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN AROUSER, ISOFORM A-RELATED cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169259|UniProtKB=T1F1N2 T1F1N2 20202732 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89720|UniProtKB=T1G7G5 T1G7G5 20217012 PTHR13723:SF200 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG190256|UniProtKB=T1FRT6 T1FRT6 20211533 PTHR11815:SF18 SUCCINYL-COA SYNTHETASE BETA CHAIN SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;tricarboxylic acid cycle#GO:0006099;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;energy derivation by oxidation of organic compounds#GO:0015980;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;aerobic respiration#GO:0009060;cellular respiration#GO:0045333 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ligase#PC00142 HELRO|EnsemblGenome=HelroG82866|UniProtKB=T1G4X6 T1G4X6 20216124 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154 monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG163072|UniProtKB=T1ETM5 T1ETM5 20199925 PTHR46016:SF1 ZINC FINGER, RING/FYVE/PHD-TYPE ZINC FINGER PROTEIN 313 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 HELRO|EnsemblGenome=HelroG190815|UniProtKB=T1FSB3 T1FSB3 20211710 PTHR13167:SF48 PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 regulation of biological quality#GO:0065008;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214;regulation of membrane potential#GO:0042391;detection of mechanical stimulus#GO:0050982;biological regulation#GO:0065007;cellular response to environmental stimulus#GO:0104004;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to mechanical stimulus#GO:0009612;response to abiotic stimulus#GO:0009628;detection of stimulus#GO:0051606 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG161252|UniProtKB=T1ER94 T1ER94 20199094 PTHR10145:SF6 TRANSCRIPTION ELONGATION FACTOR SPT6 TRANSCRIPTION ELONGATION FACTOR SPT6 chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;protein binding#GO:0005515 chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;chromatin organization#GO:0006325;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG70414|UniProtKB=T1G063 T1G063 20214461 PTHR15362:SF15 PHOSPHATIDYLINOSITOL SYNTHASE PHOSPHATIDYLSERINE SYNTHASE 1 transferase#PC00220 HELRO|EnsemblGenome=HelroG66985|UniProtKB=T1FYU8 T1FYU8 20213996 PTHR45703:SF22 DYNEIN HEAVY CHAIN CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1 microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG193937|UniProtKB=T1FVH7 T1FVH7 20212823 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG100012|UniProtKB=T1ECY0 T1ECY0 20194432 PTHR10644:SF1 DNA REPAIR/RNA PROCESSING CPSF FAMILY SPLICING FACTOR 3B SUBUNIT 3 snRNA binding#GO:0017069;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;U2 snRNP#GO:0005686;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG173964|UniProtKB=T1F7F3 T1F7F3 20204752 PTHR12307:SF36 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT polysaccharide binding#GO:0030247;phosphatase binding#GO:0019902;binding#GO:0005488;enzyme binding#GO:0019899;carbohydrate binding#GO:0030246;protein binding#GO:0005515;protein phosphatase binding#GO:0019903 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of polysaccharide metabolic process#GO:0032881;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG177421|UniProtKB=T1FBN7 T1FBN7 20206236 PTHR11977:SF130 VILLIN SEVERIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;actin filament organization#GO:0007015;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;regulation of actin filament polymerization#GO:0030833;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;supramolecular fiber organization#GO:0097435;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of actin filament depolymerization#GO:0030834 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG179686|UniProtKB=T1FF11 T1FF11 20207410 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG88288|UniProtKB=T1G711 T1G711 20216858 PTHR25480:SF0 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73 C-MAF-INDUCING PROTEIN PH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184703|UniProtKB=T1FLT3 T1FLT3 20209782 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;voltage-gated calcium channel activity#GO:0005245;channel regulator activity#GO:0016247;channel activity#GO:0015267;transporter regulator activity#GO:0141108 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;system process#GO:0003008;transmission of nerve impulse#GO:0019226;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;cell communication#GO:0007154;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641 asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG176284|UniProtKB=T1FAD2 T1FAD2 20205781 PTHR14195:SF2 G PATCH DOMAIN CONTAINING PROTEIN 2 GH10944P cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG182151|UniProtKB=T1FHU1 T1FHU1 20208390 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64745|UniProtKB=T1FXY4 T1FXY4 20213682 PTHR24089:SF769 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SCAMC transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;localization#GO:0051179;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG88194|UniProtKB=T1G6Z6 T1G6Z6 20216843 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185064|UniProtKB=T1FMC6 T1FMC6 20209975 PTHR23222:SF1 PROHIBITIN PROHIBITIN-2 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG176111|UniProtKB=T1FA53 T1FA53 20205702 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG94681|UniProtKB=T1G923 T1G923 20217570 PTHR24322:SF755 PKSB RETINOL DEHYDROGENASE 10 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 intracellular organelle#GO:0043229;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG158447|UniProtKB=T1EMT0 T1EMT0 20197880 PTHR46511:SF1 MORN REPEAT-CONTAINING PROTEIN 3 MORN REPEAT-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG79942|UniProtKB=T1G3V5 T1G3V5 20215753 PTHR24060:SF162 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR glutamate receptor activity#GO:0008066;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HELRO|EnsemblGenome=HelroG184670|UniProtKB=T1FLQ7 T1FLQ7 20209756 PTHR46169:SF30 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4 ISOFORM X1 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG134573|UniProtKB=T1EI53 T1EI53 20196253 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG163366|UniProtKB=T1ETY5 T1ETY5 20200035 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG100688|UniProtKB=T1ED12 T1ED12 20194464 PTHR12435:SF2 FAMILY NOT NAMED PROTEIN KTI12 HOMOLOG macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098 HELRO|EnsemblGenome=HelroG167352|UniProtKB=T1EZA7 T1EZA7 20201907 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN FUCOLECTIN-6-LIKE HELRO|EnsemblGenome=HelroG163780|UniProtKB=T1EUG7 T1EUG7 20200217 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159241|UniProtKB=T1ENS4 T1ENS4 20198224 PTHR35578:SF9 PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED PROLINE-RICH TRANSMEMBRANE PROTEIN 3_4 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85096|UniProtKB=T1G5S7 T1G5S7 20216424 PTHR23048:SF66 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN 2 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG156455|UniProtKB=T1ELW9 T1ELW9 20197569 PTHR11668:SF530 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Y-RELATED protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG189840|UniProtKB=T1FRE8 T1FRE8 20211395 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185976|UniProtKB=T1FNI2 T1FNI2 20210379 PTHR16950:SF25 ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4 ZINC TRANSPORTER SLC39A7 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 zinc ion transmembrane transport#GO:0071577;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG171094|UniProtKB=T1F3T0 T1F3T0 20203479 PTHR31233:SF6 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;microtubule anchoring#GO:0034453;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of microtubule-based process#GO:0032886;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG194228|UniProtKB=T1FVU2 T1FVU2 20212938 PTHR24041:SF30 MUCIN EGF-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG179632|UniProtKB=T1FEY8 T1FEY8 20207387 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG119237|UniProtKB=T1EGM7 T1EGM7 20195727 PTHR11659:SF5 GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106472|UniProtKB=T1EE27 T1EE27 20194829 PTHR11946:SF93 VALYL-TRNA SYNTHETASES VALINE--TRNA LIGASE-RELATED catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG80908|UniProtKB=T1G470 T1G470 20215868 PTHR14952:SF9 ROPPORIN-1-LIKE PROTEIN ROPPORIN-1-LIKE PROTEIN cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;cilium movement#GO:0003341;spermatid development#GO:0007286;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;sperm motility#GO:0097722;developmental process involved in reproduction#GO:0003006;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell differentiation#GO:0030154;microtubule-based movement#GO:0007018;cell motility#GO:0048870;gamete generation#GO:0007276;developmental process#GO:0032502;spermatogenesis#GO:0007283;flagellated sperm motility#GO:0030317;microtubule-based process#GO:0007017;cell maturation#GO:0048469;cellular developmental process#GO:0048869;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;sperm capacitation#GO:0048240;developmental maturation#GO:0021700;male gamete generation#GO:0048232 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG161781|UniProtKB=T1ERW8 T1ERW8 20199318 PTHR10957:SF1 RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1 GTPASE-GDP DISSOCIATION STIMULATOR VIMAR cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90723|UniProtKB=T1G7V1 T1G7V1 20217148 PTHR43272:SF32 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ligase#PC00142 HELRO|EnsemblGenome=HelroG70909|UniProtKB=T1G0E2 T1G0E2 20214540 PTHR43943:SF19 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE 4 catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG156968|UniProtKB=T1EM42 T1EM42 20197642 PTHR23235:SF194 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG143740|UniProtKB=T1EJC0 T1EJC0 20196670 PTHR13286:SF6 SAP30 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30L transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG79551|UniProtKB=T1G3Q0 T1G3Q0 20215698 PTHR11941:SF179 ENOYL-COA HYDRATASE-RELATED ENOYL-COA HYDRATASE, MITOCHONDRIAL oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;lyase#PC00144;hydratase#PC00120 HELRO|EnsemblGenome=HelroG190387|UniProtKB=T1FRY4 T1FRY4 20211581 PTHR43401:SF2 L-THREONINE 3-DEHYDROGENASE DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04620)-RELATED oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161868|UniProtKB=T1ERZ4 T1ERZ4 20199344 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77414|UniProtKB=T1G2X2 T1G2X2 20215420 PTHR15698:SF4 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG154942|UniProtKB=T1ELG5 T1ELG5 20197415 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG168982|UniProtKB=T1F179 T1F179 20202579 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 10 HELRO|EnsemblGenome=HelroG182508|UniProtKB=T1FIA5 T1FIA5 20208554 PTHR36191:SF8 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165431|UniProtKB=T1EWS1 T1EWS1 20201021 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88787|UniProtKB=T1G764 T1G764 20216911 PTHR22957:SF708 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN PH DOMAIN-CONTAINING PROTEIN enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG193199|UniProtKB=T1FUQ8 T1FUQ8 20212554 PTHR15706:SF31 SH3 MULTIPLE DOMAIN SH3 DOMAIN-CONTAINING PROTEIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular process#GO:0009987;superoxide metabolic process#GO:0006801 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG93614|UniProtKB=T1G8W9 T1G8W9 20217516 PTHR46041:SF2 MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2 MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 protein localization to mitochondrion#GO:0070585;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;protein localization to organelle#GO:0033365 endopeptidase complex#GO:1905369;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;peptidase complex#GO:1905368;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190 HELRO|EnsemblGenome=HelroG157392|UniProtKB=T1EMA7 T1EMA7 20197707 PTHR23281:SF18 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cellular component biogenesis#GO:0044087;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of biological process#GO:0048518;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;biological regulation#GO:0065007 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;adherens junction#GO:0005912;cell junction#GO:0030054;membraneless organelle#GO:0043228;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;filopodium#GO:0030175;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG72657|UniProtKB=T1G133 T1G133 20214781 PTHR11348:SF17 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN signaling receptor binding#GO:0005102;binding#GO:0005488;glycosaminoglycan binding#GO:0005539;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;carbohydrate derivative binding#GO:0097367;cell adhesion molecule binding#GO:0050839;heparin binding#GO:0008201;integrin binding#GO:0005178 cell adhesion#GO:0007155;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of developmental process#GO:0050793;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;biological regulation#GO:0065007 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 HELRO|EnsemblGenome=HelroG82780|UniProtKB=T1G4W4 T1G4W4 20216112 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987 transporter complex#GO:1990351;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG151221|UniProtKB=T1EKJ0 T1EKJ0 20197090 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG172987|UniProtKB=T1F690 T1F690 20204339 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG165230|UniProtKB=T1EWG9 T1EWG9 20200919 PTHR45901:SF3 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY PLAT DOMAINS 1 HELRO|EnsemblGenome=HelroG90364|UniProtKB=T1G7P9 T1G7P9 20217096 PTHR11654:SF678 OLIGOPEPTIDE TRANSPORTER-RELATED PEPTIDE TRANSPORTER FAMILY 1 oligopeptide transmembrane transporter activity#GO:0035673;dipeptide transmembrane transporter activity#GO:0071916;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;import into cell#GO:0098657;dipeptide transport#GO:0042938;oligopeptide transport#GO:0006857;transport#GO:0006810;import across plasma membrane#GO:0098739;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG96384|UniProtKB=T1G9B7 T1G9B7 20217664 PTHR11614:SF198 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;lipase#PC00143 HELRO|EnsemblGenome=HelroG192676|UniProtKB=T1FU65 T1FU65 20212361 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG194029|UniProtKB=T1FVL2 T1FVL2 20212858 PTHR10981:SF0 BATTENIN BATTENIN cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;vesicle localization#GO:0051648;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;vesicle cytoskeletal trafficking#GO:0099518;intracellular chemical homeostasis#GO:0055082;receptor-mediated endocytosis#GO:0006898;cellular homeostasis#GO:0019725;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;vacuolar transport#GO:0007034;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;microtubule-based movement#GO:0007018;homeostatic process#GO:0042592;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;regulation of pH#GO:0006885;organelle localization#GO:0051640;regulation of intracellular pH#GO:0051453;vesicle-mediated transport#GO:0016192;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;monoatomic ion homeostasis#GO:0050801;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;import into cell#GO:0098657;microtubule-based process#GO:0007017;amino acid transport#GO:0006865;Golgi vesicle transport#GO:0048193;chemical homeostasis#GO:0048878;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;cytosolic transport#GO:0016482;intracellular monoatomic ion homeostasis#GO:0006873;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;regulation of biological quality#GO:0065008;lysosomal transport#GO:0007041;microtubule-based transport#GO:0099111 lytic vacuole#GO:0000323;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;late endosome#GO:0005770;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;vesicle#GO:0031982;intracellular vesicle#GO:0097708 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG124011|UniProtKB=T1EGZ9 T1EGZ9 20195849 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG174536|UniProtKB=T1F883 T1F883 20205032 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172843|UniProtKB=T1F602 T1F602 20204251 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185339|UniProtKB=T1FMP4 T1FMP4 20210093 PTHR13806:SF46 FLOTILLIN-RELATED FLOTILLIN-2 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG91834|UniProtKB=T1G896 T1G896 20217293 PTHR23417:SF16 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA methylation#GO:0030488;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG181375|UniProtKB=T1FGX6 T1FGX6 20208075 PTHR24171:SF8 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 HELRO|EnsemblGenome=HelroG90722|UniProtKB=T1G7V0 T1G7V0 20217147 PTHR12778:SF10 SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED SOLUTE CARRIER FAMILY 33 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185563|UniProtKB=T1FMZ5 T1FMZ5 20210194 PTHR46555:SF1 UBIQUITIN-LIKE PROTEIN 4A UBIQUITIN-LIKE PROTEIN 4A HELRO|EnsemblGenome=HelroG83596|UniProtKB=T1G578 T1G578 20216226 PTHR21244:SF1 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24 SMALL RIBOSOMAL SUBUNIT PROTEIN US3M translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG186220|UniProtKB=T1FNU0 T1FNU0 20210487 PTHR12452:SF0 42-9-9 PROTEIN-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 transporter#PC00227 HELRO|EnsemblGenome=HelroG159283|UniProtKB=T1ENU1 T1ENU1 20198241 PTHR21567:SF90 CLASP TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 1 ISOFORM X1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185050|UniProtKB=T1FMB9 T1FMB9 20209968 PTHR23061:SF12 DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT DNA POLYMERASE ALPHA SUBUNIT B nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;DNA replication#GO:0006260;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA replication initiation#GO:0006270 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;organelle#GO:0043226;replication fork#GO:0005657;nuclear DNA-directed RNA polymerase complex#GO:0055029;replisome#GO:0030894;organelle lumen#GO:0043233;chromosome#GO:0005694;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG165746|UniProtKB=T1EX86 T1EX86 20201186 PTHR11145:SF8 BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER RE57120P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185433|UniProtKB=T1FMT6 T1FMT6 20210135 PTHR10918:SF5 HOMER WH1 DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;glutamate receptor signaling pathway#GO:0007215;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG74789|UniProtKB=T1G1Z2 T1G1Z2 20215090 PTHR12629:SF0 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;alcohol metabolic process#GO:0006066 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG194746|UniProtKB=T1FWD2 T1FWD2 20213127 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;protein folding#GO:0006457;response to stimulus#GO:0050896;protein refolding#GO:0042026;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;response to heat#GO:0009408;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG162363|UniProtKB=T1ESK4 T1ESK4 20199554 PTHR13283:SF10 KREV INTERACTION TRAPPED 1-RELATED FERM DOMAIN-CONTAINING PROTEIN 8 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175671|UniProtKB=T1F9I2 T1F9I2 20205481 PTHR10166:SF66 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VWFA DOMAIN-CONTAINING PROTEIN gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG194685|UniProtKB=T1FWB4 T1FWB4 20213110 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING IP01257P-RELATED DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG82402|UniProtKB=T1G4R8 T1G4R8 20216066 PTHR13258:SF0 SYNDETIN SYNDETIN binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 localization within membrane#GO:0051668;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192 intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;recycling endosome#GO:0055037;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG73501|UniProtKB=T1G1E7 T1G1E7 20214895 PTHR13809:SF48 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787 signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cell division#GO:0051301;cellular response to stimulus#GO:0051716;cell fate commitment#GO:0045165;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;cell population proliferation#GO:0008283;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;nervous system development#GO:0007399;asymmetric cell division#GO:0008356;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502 heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073 HELRO|EnsemblGenome=HelroG189273|UniProtKB=T1FQW6 T1FQW6 20211213 PTHR32142:SF55 B BOX-TYPE DOMAIN-CONTAINING PROTEIN-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62061|UniProtKB=T1FWV1 T1FWV1 20213299 PTHR24068:SF159 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 T acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755 protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;response to stimulus#GO:0050896;metabolic process#GO:0008152;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG163643|UniProtKB=T1EUB0 T1EUB0 20200160 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164684|UniProtKB=T1EVQ0 T1EVQ0 20200650 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG172150|UniProtKB=T1F525 T1F525 20203924 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG183748|UniProtKB=T1FK49 T1FK49 20209198 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG170017|UniProtKB=T1F2J3 T1F2J3 20203043 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189604|UniProtKB=T1FR70 T1FR70 20211317 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191126|UniProtKB=T1FSM3 T1FSM3 20211820 PTHR10133:SF64 DNA POLYMERASE I DNA POLYMERASE THETA DNA-directed DNA polymerase activity#GO:0003887;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;double-strand break repair#GO:0006302;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG93977|UniProtKB=T1G8Y4 T1G8Y4 20217531 PTHR10196:SF69 SUGAR KINASE GLYCEROL KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;acylglycerol metabolic process#GO:0006639;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;neutral lipid metabolic process#GO:0006638;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829 kinase#PC00137;carbohydrate kinase#PC00065 HELRO|EnsemblGenome=HelroG155693|UniProtKB=T1ELK7 T1ELK7 20197457 PTHR11274:SF0 RAD25/XP-B DNA REPAIR HELICASE GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE_TRANSLOCASE SUBUNIT XPB ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transcription regulator complex#GO:0005667;nucleotide-excision repair complex#GO:0000109;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG70594|UniProtKB=T1G090 T1G090 20214488 PTHR48160:SF1 LARGE RIBOSOMAL SUBUNIT PROTEIN EL43 LARGE RIBOSOMAL SUBUNIT PROTEIN EL43 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625 HELRO|EnsemblGenome=HelroG71434|UniProtKB=T1G0L6 T1G0L6 20214614 PTHR11662:SF461 SOLUTE CARRIER FAMILY 17 MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG88175|UniProtKB=T1G6Z4 T1G6Z4 20216841 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER IP12869P monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG66838|UniProtKB=T1FYR8 T1FYR8 20213966 PTHR19853:SF0 WD REPEAT CONTAINING PROTEIN 3 WDR3 WD REPEAT-CONTAINING PROTEIN 3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515 biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;90S preribosome#GO:0030686;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG183536|UniProtKB=T1FJT3 T1FJT3 20209082 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175390|UniProtKB=T1F983 T1F983 20205382 PTHR11036:SF127 SEMAPHORIN SEMAPHORIN-1A receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon development#GO:0061564;axon guidance#GO:0007411;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;cellular developmental process#GO:0048869 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG185703|UniProtKB=T1FN61 T1FN61 20210259 PTHR12399:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG167481|UniProtKB=T1EZF0 T1EZF0 20201950 PTHR14454:SF11 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER SERRANO, ISOFORM F HELRO|EnsemblGenome=HelroG189195|UniProtKB=T1FQR9 T1FQR9 20211166 PTHR14491:SF7 SOSONDOWAH, ISOFORM G SOSONDOWAH, ISOFORM G HELRO|EnsemblGenome=HelroG188027|UniProtKB=T1FPK2 T1FPK2 20210749 PTHR11208:SF42 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG183744|UniProtKB=T1FK47 T1FK47 20209196 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR MELATONIN RECEPTOR PDCR-1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157586|UniProtKB=T1EMD5 T1EMD5 20197735 PTHR44154:SF1 QUINONE OXIDOREDUCTASE ZETA-CRYSTALLIN catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;anion binding#GO:0043168;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;ion binding#GO:0043167;RNA binding#GO:0003723;purine nucleotide binding#GO:0017076;mRNA 3'-UTR binding#GO:0003730;heterocyclic compound binding#GO:1901363;binding#GO:0005488;mRNA binding#GO:0003729;nucleoside phosphate binding#GO:1901265;oxidoreductase activity, acting on NAD(P)H#GO:0016651 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Huntington disease#P00029>PIG3#G01535 HELRO|EnsemblGenome=HelroG188445|UniProtKB=T1FPZ7 T1FPZ7 20210894 PTHR12313:SF0 E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172841|UniProtKB=T1F600 T1F600 20204249 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cell-substrate adhesion#GO:0031589;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG184965|UniProtKB=T1FM78 T1FM78 20209927 PTHR11085:SF24 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL transferase activity#GO:0016740;deacylase activity#GO:0160215;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;NAD-dependent protein lysine deacetylase activity#GO:0034979;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;acyltransferase activity#GO:0016746;histone modifying activity#GO:0140993;hydrolase activity#GO:0016787;deacetylase activity#GO:0019213 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG194327|UniProtKB=T1FVX9 T1FVX9 20212975 PTHR31233:SF6 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;microtubule anchoring#GO:0034453;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;regulation of microtubule-based process#GO:0032886 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191379|UniProtKB=T1FSX9 T1FSX9 20211926 PTHR10145:SF6 TRANSCRIPTION ELONGATION FACTOR SPT6 TRANSCRIPTION ELONGATION FACTOR SPT6 histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription elongation#GO:0006354;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG177703|UniProtKB=T1FC39 T1FC39 20206388 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG107531|UniProtKB=T1EEA9 T1EEA9 20194911 PTHR24055:SF391 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Parkinson disease#P00049>ERK#P01211;Wnt signaling pathway#P00057>Nemo-like Kinase#P01449;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Apoptosis signaling pathway#P00006>MAPK#P00269;FGF signaling pathway#P00021>ERK1-2#P00627;Endothelin signaling pathway#P00019>ERK#P00566;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;EGF receptor signaling pathway#P00018>ERK1-2#P00543 HELRO|EnsemblGenome=HelroG164015|UniProtKB=T1EUR7 T1EUR7 20200317 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186088|UniProtKB=T1FNN1 T1FNN1 20210428 PTHR10849:SF20 NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;electron transport chain#GO:0022900;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904 membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG116733|UniProtKB=T1EGH4 T1EGH4 20195676 PTHR44395:SF1 FAMILY NOT NAMED PROTEIN O-MANNOSYL-TRANSFERASE TMTC3 HELRO|EnsemblGenome=HelroG130520|UniProtKB=T1EHU0 T1EHU0 20196140 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG69335|UniProtKB=T1FZT3 T1FZT3 20214331 PTHR11753:SF2 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY ADAPTOR PROTEIN COMPLEX AP-3 SMALL CHAIN SIGMA3 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170902|UniProtKB=T1F3K7 T1F3K7 20203406 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG193498|UniProtKB=T1FV21 T1FV21 20212667 PTHR42733:SF13 DJ-1 PROTEIN CYSTEINE PROTEASE YRAA ISOFORM X1 protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG115966|UniProtKB=T1EGC1 T1EGC1 20195623 PTHR23354:SF122 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED GTPASE-ACTIVATING PROTEIN SKYWALKER HELRO|EnsemblGenome=HelroG193606|UniProtKB=T1FV63 T1FV63 20212709 PTHR44167:SF18 OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED PHOSPHORYLASE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG184726|UniProtKB=T1FLV4 T1FLV4 20209803 PTHR10722:SF0 60S RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN EL19 binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;structural molecule activity#GO:0005198;RNA binding#GO:0003723 intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG186549|UniProtKB=T1FP09 T1FP09 20210556 PTHR11280:SF5 GLUCOSAMINE-6-PHOSPHATE ISOMERASE GLUCOSAMINE-6-PHOSPHATE DEAMINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;protein binding#GO:0005515;hydrolase activity#GO:0016787;deaminase activity#GO:0019239;identical protein binding#GO:0042802;catalytic activity#GO:0003824;binding#GO:0005488 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;carboxylic acid metabolic process#GO:0019752;carbohydrate derivative metabolic process#GO:1901135;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;amino sugar catabolic process#GO:0046348;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 isomerase#PC00135 N-acetylglucosamine metabolism#P02756>Glucosamine-6-phosphate deaminase#P03041 HELRO|EnsemblGenome=HelroG184382|UniProtKB=T1FL35 T1FL35 20209534 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG105257|UniProtKB=T1EDS5 T1EDS5 20194727 PTHR31733:SF1 RIBONUCLEASE KAPPA RIBONUCLEASE KAPPA establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG109312|UniProtKB=T1EES3 T1EES3 20195075 PTHR46212:SF3 PEFLIN PROGRAMMED CELL DEATH PROTEIN 6 HELRO|EnsemblGenome=HelroG91978|UniProtKB=T1G8B2 T1G8B2 20217309 PTHR21442:SF0 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206 regulation of microtubule-based process#GO:0032886;regulation of biological process#GO:0050789;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG162504|UniProtKB=T1ESR6 T1ESR6 20199616 PTHR12977:SF4 SUPPRESSOR OF VARIEGATION 4-20-RELATED HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B-RELATED HELRO|EnsemblGenome=HelroG162182|UniProtKB=T1ESC0 T1ESC0 20199470 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4 INTERACTING CHROMATIN REMODELING COMPLEX ASSOCIATED PROTEIN, ISOFORM B positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG185933|UniProtKB=T1FNG3 T1FNG3 20210360 PTHR13691:SF73 RIBOSOMAL PROTEIN L2 LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 organelle lumen#GO:0043233;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG191168|UniProtKB=T1FSP5 T1FSP5 20211842 PTHR31220:SF10 HYCCIN RELATED GH21176P intracellular protein localization#GO:0008104;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;protein localization to cell periphery#GO:1990778;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;cellular localization#GO:0051641;organophosphate biosynthetic process#GO:0090407;localization#GO:0051179;localization within membrane#GO:0051668;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG159498|UniProtKB=T1EP36 T1EP36 20198336 PTHR45961:SF6 IP21249P IP21249P phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG158078|UniProtKB=T1EMJ1 T1EMJ1 20197791 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;system development#GO:0048731;cell fate commitment#GO:0045165;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HELRO|EnsemblGenome=HelroG160078|UniProtKB=T1EPR1 T1EPR1 20198561 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182404|UniProtKB=T1FI55 T1FI55 20208504 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105304|UniProtKB=T1EDT6 T1EDT6 20194738 PTHR43986:SF1 ELONGATION FACTOR 1-GAMMA ELONGATION FACTOR 1-GAMMA translation#GO:0006412;metabolic process#GO:0008152;translational elongation#GO:0006414;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG168922|UniProtKB=T1F149 T1F149 20202549 PTHR21522:SF32 PROTON CHANNEL OTOP PROTON CHANNEL OTOPLC monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;proton channel activity#GO:0015252;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG180097|UniProtKB=T1FFG8 T1FFG8 20207567 PTHR12232:SF15 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG185681|UniProtKB=T1FN50 T1FN50 20210248 PTHR11851:SF149 METALLOPROTEASE MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT BETA metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;endopeptidase complex#GO:1905369;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;peptidase complex#GO:1905368;membrane-enclosed lumen#GO:0031974 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG173379|UniProtKB=T1F6R0 T1F6R0 20204509 PTHR32055:SF1 INTEGRIN BETA-1-BINDING PROTEIN 1 INTEGRIN BETA-1-BINDING PROTEIN 1 signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877 regulation of cell junction assembly#GO:1901888;negative regulation of cellular process#GO:0048523;regulation of cell-matrix adhesion#GO:0001952;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lamellipodium#GO:0030027;cell periphery#GO:0071944;cell leading edge#GO:0031252;intracellular anatomical structure#GO:0005622;ruffle#GO:0001726;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG174026|UniProtKB=T1F7I0 T1F7I0 20204779 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166054|UniProtKB=T1EXN1 T1EXN1 20201331 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161549|UniProtKB=T1ERL9 T1ERL9 20199219 PTHR16222:SF44 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG169113|UniProtKB=T1F1E9 T1F1E9 20202649 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180130|UniProtKB=T1FFI1 T1FFI1 20207580 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD LICD_FKTN_FKRP NUCLEOTIDYLTRANSFERASE DOMAIN-CONTAINING PROTEIN transferase#PC00220 HELRO|EnsemblGenome=HelroG183219|UniProtKB=T1FJC0 T1FJC0 20208919 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG189280|UniProtKB=T1FQW9 T1FQW9 20211216 PTHR14523:SF1 UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN HELRO|EnsemblGenome=HelroG166293|UniProtKB=T1EXZ7 T1EXZ7 20201447 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126586|UniProtKB=T1EHA5 T1EHA5 20195955 PTHR45636:SF56 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED EYEGONE, ISOFORM A-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG195157|UniProtKB=T1FWT7 T1FWT7 20213282 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185299|UniProtKB=T1FMM7 T1FMM7 20210076 PTHR12646:SF0 NOT56 - RELATED DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG90797|UniProtKB=T1G7W5 T1G7W5 20217162 PTHR24070:SF468 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE PROTEIN 1 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;epidermal growth factor receptor signaling pathway#GO:0007173;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;PDGF signaling pathway#P00047>Ras#P01154;EGF receptor signaling pathway#P00018>Ras#P00552;Ras Pathway#P04393>Ras#P04547;Integrin signalling pathway#P00034>Ras#P00916;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;VEGF signaling pathway#P00056>Ras#P01411;PI3 kinase pathway#P00048>Ras#P01182;Angiogenesis#P00005>Ras#P00238;p53 pathway feedback loops 2#P04398>Ras#P04651;FGF signaling pathway#P00021>Ras#P00633 HELRO|EnsemblGenome=HelroG182385|UniProtKB=T1FI44 T1FI44 20208493 PTHR22600:SF65 BETA-HEXOSAMINIDASE BETA-N-ACETYLHEXOSAMINIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;cell periphery#GO:0071944;lysosome#GO:0005764;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG163207|UniProtKB=T1ETS9 T1ETS9 20199979 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG82735|UniProtKB=T1G4V9 T1G4V9 20216107 PTHR15741:SF37 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR LD38259P RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG110500|UniProtKB=T1EF29 T1EF29 20195181 PTHR23235:SF182 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 2 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG147243|UniProtKB=T1EJY4 T1EJY4 20196884 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94829|UniProtKB=T1G933 T1G933 20217580 PTHR11588:SF462 TUBULIN TUBULIN ALPHA CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488 cellular process#GO:0009987;organelle organization#GO:0006996;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;microtubule-based process#GO:0007017;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell differentiation#GO:0030154;mitotic cell cycle#GO:0000278;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 HELRO|EnsemblGenome=HelroG77423|UniProtKB=T1G2X5 T1G2X5 20215423 PTHR13423:SF2 OUT AT FIRST OUT AT FIRST PROTEIN HOMOLOG HELRO|EnsemblGenome=HelroG93524|UniProtKB=T1G8W2 T1G8W2 20217509 PTHR11552:SF233 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE FI02019P catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194795|UniProtKB=T1FWF1 T1FWF1 20213146 PTHR13483:SF3 BOX C_D SNORNA PROTEIN 1-RELATED BOX C_D SNORNA PROTEIN 1 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;cellular component assembly#GO:0022607 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG193983|UniProtKB=T1FVJ3 T1FVJ3 20212839 PTHR23168:SF0 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 mitotic spindle assembly checkpoint signaling#GO:0007094;attachment of spindle microtubules to kinetochore#GO:0008608;chromosome localization#GO:0050000;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;chromosome segregation#GO:0007059;regulation of chromosome segregation#GO:0051983;metaphase chromosome alignment#GO:0051310;negative regulation of cell cycle#GO:0045786;cellular component organization#GO:0016043;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of mitotic cell cycle#GO:0007346;mitotic sister chromatid segregation#GO:0000070;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;mitotic metaphase chromosome alignment#GO:0007080;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;organelle localization#GO:0051640;negative regulation of chromosome organization#GO:2001251;intracellular signal transduction#GO:0035556;organelle fission#GO:0048285;cell communication#GO:0007154;localization#GO:0051179;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of sister chromatid segregation#GO:0033046;organelle organization#GO:0006996;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of chromosome segregation#GO:0051985;cellular component organization or biogenesis#GO:0071840;regulation of organelle organization#GO:0033043;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;nuclear chromosome segregation#GO:0098813;negative regulation of cell cycle phase transition#GO:1901988;sister chromatid segregation#GO:0000819;negative regulation of biological process#GO:0048519;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;nuclear division#GO:0000280;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;negative regulation of organelle organization#GO:0010639;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;regulation of mitotic sister chromatid segregation#GO:0033047 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;kinetochore#GO:0000776;organelle envelope#GO:0031967;chromosome#GO:0005694;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle#GO:0005819;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;membraneless organelle#GO:0043228;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nuclear envelope#GO:0005635;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG85518|UniProtKB=T1G5Y4 T1G5Y4 20216481 PTHR23359:SF111 NUCLEOTIDE KINASE ADENYLATE KINASE ISOENZYME 5 phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside diphosphate metabolic process#GO:0009132;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;ribonucleoside diphosphate metabolic process#GO:0009185;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG186529|UniProtKB=T1FP07 T1FP07 20210554 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate derivative binding#GO:0097367;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;ADP catabolic process#GO:0046032;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220;carbohydrate kinase#PC00065;kinase#PC00137 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG181208|UniProtKB=T1FGQ8 T1FGQ8 20208007 PTHR24404:SF116 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG158058|UniProtKB=T1EMI9 T1EMI9 20197789 PTHR11545:SF3 RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN UL13 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of translation#GO:0017148;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG92881|UniProtKB=T1G8M9 T1G8M9 20217426 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;cell fate specification#GO:0001708;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG78061|UniProtKB=T1G373 T1G373 20215521 PTHR13710:SF152 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q5 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG100028|UniProtKB=T1ECY2 T1ECY2 20194434 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG91460|UniProtKB=T1G841 T1G841 20217238 PTHR11904:SF9 METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763 primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside metabolic process#GO:0009116;catabolic process#GO:0009056;purine nucleoside metabolic process#GO:0042278;pyridine-containing compound metabolic process#GO:0072524;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule catabolic process#GO:0034656;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside catabolic process#GO:0009164;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;purine nucleoside catabolic process#GO:0006152;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 kinase#PC00137;nucleotide kinase#PC00172 Adenine and hypoxanthine salvage pathway#P02723>Inosine phosphorylase#P02813;Xanthine and guanine salvage pathway#P02788>Deoxyguanosine phosphorylase#P03248;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine phosphorylase#P02808;Adenine and hypoxanthine salvage pathway#P02723>Deoxyinosine phosphorylase#P02812;Adenine and hypoxanthine salvage pathway#P02723>Adenine phosphorylase#P02805;Xanthine and guanine salvage pathway#P02788>Guanosine phosphorylase#P03250 HELRO|EnsemblGenome=HelroG189158|UniProtKB=T1FQQ4 T1FQQ4 20211151 PTHR11937:SF607 ACTIN ACTIN-42A-RELATED structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;cell division#GO:0051301;cellular component organization#GO:0016043;cell cycle#GO:0007049;cytoskeleton-dependent cytokinesis#GO:0061640;cortical actin cytoskeleton organization#GO:0030866;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;cytokinesis#GO:0000910 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG191038|UniProtKB=T1FSJ0 T1FSJ0 20211787 PTHR15141:SF76 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185306|UniProtKB=T1FMN1 T1FMN1 20210080 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163463|UniProtKB=T1EU31 T1EU31 20200081 PTHR24034:SF209 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG76893|UniProtKB=T1G2Q6 T1G2Q6 20215354 PTHR19353:SF88 FATTY ACID DESATURASE 2 DELTA(5) FATTY ACID DESATURASE FAT-4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629 membrane#GO:0016020;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG161955|UniProtKB=T1ES30 T1ES30 20199380 PTHR21963:SF1 PF6 SPERM-ASSOCIATED ANTIGEN 17 cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 axoneme#GO:0005930;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axonemal central apparatus#GO:1990716;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG161476|UniProtKB=T1ERI4 T1ERI4 20199184 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191216|UniProtKB=T1FSR1 T1FSR1 20211858 PTHR24073:SF1125 DRAB5-RELATED RAS-RELATED PROTEIN RAB-43 catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG170743|UniProtKB=T1F3D7 T1F3D7 20203336 PTHR28360:SF1 DYNACTIN SUBUNIT 3 DYNACTIN SUBUNIT 3 cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;cell cycle#GO:0007049;cell cycle process#GO:0022402;cell division#GO:0051301;cellular process#GO:0009987 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG65797|UniProtKB=T1FYC7 T1FYC7 20213825 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 SNARE binding#GO:0000149;binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;protein binding#GO:0005515 vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;regulation of transport#GO:0051049;positive regulation of vesicle fusion#GO:0031340;regulation of localization#GO:0032879;regulated exocytosis#GO:0045055;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;signaling#GO:0023052;export from cell#GO:0140352;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;secretion#GO:0046903;regulation of exocytosis#GO:0017157;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643 organelle membrane#GO:0031090;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;axon#GO:0030424;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular vesicle#GO:0097708;cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG194881|UniProtKB=T1FWJ0 T1FWJ0 20213185 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG100627|UniProtKB=T1ED08 T1ED08 20194460 PTHR12785:SF19 SPLICING FACTOR 3B SPLICING FACTOR 3B SUBUNIT 2 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2 snRNP#GO:0005686;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG80604|UniProtKB=T1G427 T1G427 20215825 PTHR11177:SF317 CHITINASE GH18 DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;chitinase activity#GO:0004568;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;amino sugar metabolic process#GO:0006040;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;amino sugar catabolic process#GO:0046348;chitin catabolic process#GO:0006032;aminoglycan catabolic process#GO:0006026;chitin metabolic process#GO:0006030;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;macromolecule catabolic process#GO:0009057 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG190695|UniProtKB=T1FS76 T1FS76 20211673 PTHR14689:SF0 PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 82 HELRO|EnsemblGenome=HelroG96321|UniProtKB=T1G9B3 T1G9B3 20217660 PTHR12737:SF9 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE GM09012P hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG163396|UniProtKB=T1EU00 T1EU00 20200050 PTHR46825:SF9 D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG166441|UniProtKB=T1EY50 T1EY50 20201500 PTHR19871:SF14 BETA TRANSDUCIN-RELATED PROTEIN NACHT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190459|UniProtKB=T1FS03 T1FS03 20211600 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG160940|UniProtKB=T1EQV9 T1EQV9 20198959 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG97989|UniProtKB=T1G9J8 T1G9J8 20217744 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG enzyme activator activity#GO:0008047;binding#GO:0005488;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;protein metabolic process#GO:0019538;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;proteasomal protein catabolic process#GO:0010498;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;macromolecule catabolic process#GO:0009057;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;positive regulation of metabolic process#GO:0009893 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165466|UniProtKB=T1EWU7 T1EWU7 20201047 PTHR23320:SF176 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED SUBFAMILY NOT NAMED transporter#PC00227 HELRO|EnsemblGenome=HelroG101372|UniProtKB=T1ED42 T1ED42 20213287 PTHR23122:SF72 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182608|UniProtKB=T1FIG9 T1FIG9 20208618 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG158762|UniProtKB=T1EN83 T1EN83 20198033 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185806|UniProtKB=T1FNB3 T1FNB3 20210310 PTHR31019:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 14 SMALL INTEGRAL MEMBRANE PROTEIN 14 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG190072|UniProtKB=T1FRN4 T1FRN4 20211481 PTHR13237:SF8 SOMETHING ABOUT SILENCING PROTEIN 10-RELATED SOMETHING ABOUT SILENCING PROTEIN 10 ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG110329|UniProtKB=T1EF15 T1EF15 20195167 PTHR20939:SF11 SORTING NEXIN 20, 21 LD12265P binding#GO:0005488;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;early endosome membrane#GO:0031901 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG115899|UniProtKB=T1EGB5 T1EGB5 20195617 PTHR12743:SF0 CYTOCHROME C1 HEME LYASE HOLOCYTOCHROME C-TYPE SYNTHASE catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846;catalytic activity, acting on a protein#GO:0140096 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 lyase#PC00144 HELRO|EnsemblGenome=HelroG190435|UniProtKB=T1FRZ6 T1FRZ6 20211593 PTHR13021:SF8 PRE-MRNA-SPLICING FACTOR ISY1 PRE-MRNA-SPLICING FACTOR ISY1 HOMOLOG RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376 spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG97107|UniProtKB=T1G9F5 T1G9F5 20217702 PTHR42693:SF33 ARYLSULFATASE FAMILY MEMBER PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG168600|UniProtKB=T1F0S3 T1F0S3 20202423 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG102846|UniProtKB=T1EDC3 T1EDC3 20194575 PTHR46770:SF1 HOMEOBOX PROTEIN ORTHOPEDIA HOMEOBOX PROTEIN ORTHOPEDIA DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular process#GO:0009987;nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG80026|UniProtKB=T1G3W7 T1G3W7 20215765 PTHR24056:SF189 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;cyclin binding#GO:0030332;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;cyclin-dependent protein kinase activity#GO:0097472;cyclin-dependent protein serine/threonine kinase activity#GO:0004693 transferase complex#GO:1990234;protein kinase complex#GO:1902911;nucleus#GO:0005634;cytosol#GO:0005829;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG87827|UniProtKB=T1G6V9 T1G6V9 20216806 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG157121|UniProtKB=T1EM64 T1EM64 20197664 PTHR45629:SF17 SNF2/RAD54 FAMILY MEMBER DNA REPAIR AND RECOMBINATION PROTEIN RAD54-LIKE DNA translocase activity#GO:0015616;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;response to stimulus#GO:0050896;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;sexual reproduction#GO:0019953;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG192181|UniProtKB=T1FTN7 T1FTN7 20212184 PTHR22951:SF115 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP SNARE binding#GO:0000149;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515 clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657 cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;clathrin-coated vesicle#GO:0030136;synaptic membrane#GO:0097060;transport vesicle#GO:0030133;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;membrane#GO:0016020;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG158768|UniProtKB=T1EN87 T1EN87 20198037 PTHR28624:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 51 MITOCHONDRIAL POTASSIUM CHANNEL HELRO|EnsemblGenome=HelroG191885|UniProtKB=T1FTE0 T1FTE0 20212087 PTHR24023:SF1140 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG184582|UniProtKB=T1FLI9 T1FLI9 20209688 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66091|UniProtKB=T1FYG9 T1FYG9 20213867 PTHR24012:SF812 RNA BINDING PROTEIN RNA-BINDING PROTEIN 45 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG106899|UniProtKB=T1EE58 T1EE58 20194860 PTHR48081:SF36 AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C KYNURENINE FORMAMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG115616|UniProtKB=T1EG96 T1EG96 20195598 PTHR48051:SF33 FAMILY NOT NAMED LEUCINE-RICH REPEAT PROTEIN SHOC-2 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186138|UniProtKB=T1FNP9 T1FNP9 20210446 PTHR43028:SF5 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;phosphatase activity#GO:0016791 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG119140|UniProtKB=T1EGM5 T1EGM5 20195725 PTHR24416:SF539 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR PROTEIN-TYROSINE KINASE signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transmembrane signaling receptor activity#GO:0004888 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163438|UniProtKB=T1EU18 T1EU18 20200068 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG189679|UniProtKB=T1FR91 T1FR91 20211338 PTHR11564:SF40 SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54 SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54 hydrolase activity#GO:0016787;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;signal sequence receptor activity#GO:0005048;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;protein transport#GO:0015031;protein targeting#GO:0006605;protein targeting to membrane#GO:0006612;intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein targeting to ER#GO:0045047;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of protein localization to endoplasmic reticulum#GO:0072599 signal recognition particle, endoplasmic reticulum targeting#GO:0005786;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG71618|UniProtKB=T1G0P1 T1G0P1 20214639 PTHR45134:SF22 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169145|UniProtKB=T1F1G8 T1F1G8 20202668 PTHR47027:SF32 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98479|UniProtKB=T1G9N0 T1G9N0 20217776 PTHR45619:SF12 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE PP2A catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular process#GO:0009987 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway feedback loops 2#P04398>PP2A-C#P04659;Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;p53 pathway#P00059>PP2A#P04630;EGF receptor signaling pathway#P00018>PP2A#P00547;p53 pathway by glucose deprivation#P04397>PP2A-C#P04643 HELRO|EnsemblGenome=HelroG89655|UniProtKB=T1G7F5 T1G7F5 20217002 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG162835|UniProtKB=T1ET88 T1ET88 20199788 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90130|UniProtKB=T1G7L5 T1G7L5 20217062 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG174778|UniProtKB=T1F8G6 T1F8G6 20205115 PTHR28598:SF1 STAGA COMPLEX 65 SUBUNIT GAMMA STAGA COMPLEX 65 SUBUNIT GAMMA transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 HELRO|EnsemblGenome=HelroG93198|UniProtKB=T1G8U3 T1G8U3 20217490 PTHR46042:SF1 DIPHTHINE METHYLTRANSFERASE DIPHTHINE METHYLTRANSFERASE macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG189040|UniProtKB=T1FQL0 T1FQL0 20211107 PTHR24356:SF449 SERINE/THREONINE-PROTEIN KINASE 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 response to endogenous stimulus#GO:0009719;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to peptide hormone stimulus#GO:0071375;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;response to hormone#GO:0009725;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166 non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>PDK1/2#P04616;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PDK1#P00831;PI3 kinase pathway#P00048>P110ACT#P01177;Ras Pathway#P04393>PDK#P04555;Interleukin signaling pathway#P00036>PDK1/2#P00985;PI3 kinase pathway#P00048>PDK1#P01196;CCKR signaling map#P06959>PDPK1#P07162;PI3 kinase pathway#P00048>PDK1 ACT#P01190;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PDK1/2#P00903;PDGF signaling pathway#P00047>PDK1/2#P01164;p53 pathway feedback loops 2#P04398>PDK1/2#P04656 HELRO|EnsemblGenome=HelroG195030|UniProtKB=T1FWP0 T1FWP0 20213235 PTHR13020:SF25 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 PROTEIN GAWKY positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;miRNA-mediated post-transcriptional gene silencing#GO:0035195;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;positive regulation of metabolic process#GO:0009893;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG163056|UniProtKB=T1ETM0 T1ETM0 20199920 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG62232|UniProtKB=T1FWX4 T1FWX4 20213322 PTHR22168:SF8 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG184021|UniProtKB=T1FKF9 T1FKF9 20209308 PTHR22906:SF21 PROPERDIN ADHESION G PROTEIN-COUPLED RECEPTOR B1-LIKE HELRO|EnsemblGenome=HelroG161177|UniProtKB=T1ER71 T1ER71 20199071 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG152153|UniProtKB=T1EKP9 T1EKP9 20197149 PTHR45255:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 24 DNAJ HOMOLOG SUBFAMILY C MEMBER 24 iron ion binding#GO:0005506;ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772;ferrous iron binding#GO:0008198;metal ion binding#GO:0046872;cation binding#GO:0043169;molecular function activator activity#GO:0140677;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914 chaperone#PC00072 HELRO|EnsemblGenome=HelroG114397|UniProtKB=T1EG13 T1EG13 20195515 PTHR15301:SF12 INSULIN-INDUCED GENE 1 INSULIN-INDUCED GENE PROTEIN metabolic process#GO:0008152;response to chemical#GO:0042221;response to lipid#GO:0033993;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;response to hormone#GO:0009725;response to stress#GO:0006950;negative regulation of intracellular signal transduction#GO:1902532;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;intracellular protein localization#GO:0008104;regulation of response to stress#GO:0080134;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;cellular response to nitrogen compound#GO:1901699;regulation of signal transduction#GO:0009966;macromolecule localization#GO:0033036;cell communication#GO:0007154;localization#GO:0051179;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cellular response to peptide hormone stimulus#GO:0071375;alcohol metabolic process#GO:0006066;cholesterol biosynthetic process#GO:0006695;cellular response to lipid#GO:0071396;negative regulation of signal transduction#GO:0009968;alcohol biosynthetic process#GO:0046165;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cellular localization#GO:0051641;negative regulation of cell communication#GO:0010648;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;secondary alcohol metabolic process#GO:1902652;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;secondary alcohol biosynthetic process#GO:1902653;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;cholesterol metabolic process#GO:0008203;cellular response to insulin stimulus#GO:0032869;lipid biosynthetic process#GO:0008610;negative regulation of response to stimulus#GO:0048585;biosynthetic process#GO:0009058;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;SREBP signaling pathway#GO:0032933;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG192853|UniProtKB=T1FUD0 T1FUD0 20212426 PTHR45868:SF80 HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED F15K9.8-RELATED HELRO|EnsemblGenome=HelroG166232|UniProtKB=T1EXX4 T1EXX4 20201424 PTHR46115:SF13 THIOREDOXIN-LIKE PROTEIN 1 THIOREDOXIN 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 oxidoreductase#PC00176 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG165053|UniProtKB=T1EW76 T1EW76 20200826 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164376|UniProtKB=T1EVC4 T1EVC4 20200524 PTHR10913:SF45 FOLLISTATIN-RELATED AGRIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG185302|UniProtKB=T1FMN0 T1FMN0 20210079 PTHR19359:SF14 CYTOCHROME B5 CYTOCHROME B5 tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;binding#GO:0005488 membrane#GO:0016020;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191436|UniProtKB=T1FSZ4 T1FSZ4 20211941 PTHR45702:SF2 ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER ADAM10 ENDOPEPTIDASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;membrane protein proteolysis#GO:0033619;primary metabolic process#GO:0044238;membrane protein ectodomain proteolysis#GO:0006509 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190 Alzheimer disease-amyloid secretase pathway#P00003>ADAM10#P00108 HELRO|EnsemblGenome=HelroG69402|UniProtKB=T1FZU8 T1FZU8 20214346 PTHR11158:SF17 MSF1/PX19 RELATED PROTEIN SLOWMO lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 lipid localization#GO:0010876;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;lipid transport#GO:0006869;organophosphate ester transport#GO:0015748;phospholipid transport#GO:0015914 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG113765|UniProtKB=T1EFW0 T1EFW0 20195462 PTHR23326:SF1 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252 membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;CCR4-NOT complex#GO:0030014 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84516|UniProtKB=T1G5J5 T1G5J5 20216342 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular developmental process#GO:0048869;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG182920|UniProtKB=T1FIX5 T1FIX5 20208774 PTHR11375:SF0 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG110204|UniProtKB=T1EF04 T1EF04 20195156 PTHR33442:SF1 TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG81061|UniProtKB=T1G483 T1G483 20215881 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161992|UniProtKB=T1ES46 T1ES46 20199396 PTHR11588:SF6 TUBULIN TUBULIN DELTA CHAIN GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198 mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 tubulin#PC00228;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG157926|UniProtKB=T1EMH8 T1EMH8 20197778 PTHR10371:SF3 NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;catalytic activity#GO:0003824;NADH dehydrogenase activity#GO:0003954 mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020 dehydrogenase#PC00092;oxidoreductase#PC00176 Parkinson disease#P00049>Complex I#P01237 HELRO|EnsemblGenome=HelroG165781|UniProtKB=T1EXA0 T1EXA0 20201200 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG72508|UniProtKB=T1G110 T1G110 20214758 PTHR19300:SF65 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG89946|UniProtKB=T1G7J3 T1G7J3 20217040 PTHR23255:SF98 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE PUT phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;activin binding#GO:0048185;kinase activity#GO:0016301;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to growth factor stimulus#GO:0071363;pattern specification process#GO:0007389;activin receptor signaling pathway#GO:0032924 transferase complex, transferring phosphorus-containing groups#GO:0061695;signaling receptor complex#GO:0043235;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;ALP23B signaling pathway#P06209>PUT#P06218;GBB signaling pathway#P06214>PUT#P06304;SCW signaling pathway#P06216>PUT#P06320;DPP signaling pathway#P06213>PUT#P06277;DPP-SCW signaling pathway#P06212>PUT#P06270;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR II#P06255;Activin beta signaling pathway#P06210>PUT#P06229 HELRO|EnsemblGenome=HelroG72628|UniProtKB=T1G129 T1G129 20214777 PTHR13172:SF0 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 B protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial intermembrane space#GO:0005758;mitochondrial envelope#GO:0005740;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG184909|UniProtKB=T1FM59 T1FM59 20209908 PTHR45618:SF13 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL DICARBOXYLATE CARRIER succinate transmembrane transporter activity#GO:0015141;dicarboxylic acid transmembrane transporter activity#GO:0005310;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;C4-dicarboxylate transmembrane transporter activity#GO:0015556 inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;organic acid transport#GO:0015849;C4-dicarboxylate transport#GO:0015740;transport#GO:0006810;carboxylic acid transport#GO:0046942;phosphate ion transport#GO:0006817;dicarboxylic acid transport#GO:0006835;carboxylic acid transmembrane transport#GO:1905039;succinate transport#GO:0015744;cellular process#GO:0009987 mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG81599|UniProtKB=T1G4G2 T1G4G2 20215960 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG168801|UniProtKB=T1F0Z7 T1F0Z7 20202497 PTHR31711:SF1 ARGININE AND GLUTAMATE-RICH PROTEIN 1 ARGININE AND GLUTAMATE-RICH PROTEIN 1 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;mitochondrion#GO:0005739;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG169904|UniProtKB=T1F2F4 T1F2F4 20203004 PTHR35270:SF2 FUSELESS, ISOFORM A SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG182820|UniProtKB=T1FIT0 T1FIT0 20208729 PTHR10075:SF116 BASIGIN RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG191143|UniProtKB=T1FSN1 T1FSN1 20211828 PTHR18945:SF914 NEUROTRANSMITTER GATED ION CHANNEL NEUROTRANSMITTER-GATED ION-CHANNEL LIGAND-BINDING DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG191910|UniProtKB=T1FTE7 T1FTE7 20212094 PTHR33562:SF27 ATILLA, ISOFORM B-RELATED-RELATED FI02817P-RELATED HELRO|EnsemblGenome=HelroG174471|UniProtKB=T1F857 T1F857 20205006 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG182599|UniProtKB=T1FIG0 T1FIG0 20208609 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG183798|UniProtKB=T1FK75 T1FK75 20209224 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89788|UniProtKB=T1G7H7 T1G7H7 20217024 PTHR45676:SF98 RING-H2 FINGER PROTEIN ATL51-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE HELRO|EnsemblGenome=HelroG181382|UniProtKB=T1FGY1 T1FGY1 20208080 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194939|UniProtKB=T1FWL4 T1FWL4 20213209 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE FI04477P-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 dephosphorylation#GO:0016311;cell communication#GO:0007154;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG66888|UniProtKB=T1FYS5 T1FYS5 20213973 PTHR11085:SF9 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 acyltransferase activity#GO:0016746;transcription regulator activity#GO:0140110;deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407;transcription corepressor activity#GO:0003714;deacylase activity#GO:0160215;transferase activity#GO:0016740;NAD-dependent protein lysine deacetylase activity#GO:0034979;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular process#GO:0009987;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;constitutive heterochromatin formation#GO:0140719;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;nuclear envelope#GO:0005635;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;organelle inner membrane#GO:0019866;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;nuclear membrane#GO:0031965;nuclear inner membrane#GO:0005637;organelle membrane#GO:0031090;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 p53 pathway#P00059>SIRT-1#P04632 HELRO|EnsemblGenome=HelroG62661|UniProtKB=T1FX32 T1FX32 20213380 PTHR10029:SF3 ACYLPHOSPHATASE ACYLPHOSPHATASE-1 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG70686|UniProtKB=T1G0A6 T1G0A6 20214504 PTHR43028:SF5 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG111918|UniProtKB=T1EFF8 T1EFF8 20195310 PTHR10829:SF23 CORTACTIN AND DREBRIN CORTACTIN, ISOFORM A binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;cell migration#GO:0016477 site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin filament#GO:0005884;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG178815|UniProtKB=T1FDS3 T1FDS3 20206972 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG67136|UniProtKB=T1FYX2 T1FYX2 20214020 PTHR23245:SF25 TRNA METHYLTRANSFERASE TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;methylation#GO:0032259;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG67728|UniProtKB=T1FZ45 T1FZ45 20214093 PTHR21281:SF0 CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1 CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG127646|UniProtKB=T1EHG2 T1EHG2 20196012 PTHR11849:SF320 ETS DNA-BINDING PROTEIN D-ETS-4 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG133553|UniProtKB=T1EI14 T1EI14 20196214 PTHR20855:SF147 ADIPOR/PROGESTIN RECEPTOR-RELATED PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3-LIKE signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178766|UniProtKB=T1FDP5 T1FDP5 20206944 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN YEATS DOMAIN-CONTAINING PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG109171|UniProtKB=T1EEQ9 T1EEQ9 20195061 PTHR10177:SF344 CYCLINS G1_S-SPECIFIC CYCLIN-E cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;enzyme regulator activity#GO:0030234 mitotic cell cycle phase transition#GO:0044772;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;G1/S transition of mitotic cell cycle#GO:0000082;positive regulation of cell cycle G1/S phase transition#GO:1902808;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G1/S phase transition#GO:0044843;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 p53 pathway feedback loops 2#P04398>cyclin E#P04664;Cell cycle#P00013>Cyclin E#P00483;Cell cycle#P00013>CdkC#P00489;p53 pathway#P00059>Cyclin E#P04610 HELRO|EnsemblGenome=HelroG183493|UniProtKB=T1FJR3 T1FJR3 20209062 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG185055|UniProtKB=T1FMC0 T1FMC0 20209969 PTHR31212:SF4 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3 DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG144735|UniProtKB=T1EJG1 T1EJG1 20196711 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG74196|UniProtKB=T1G1N6 T1G1N6 20214984 PTHR10993:SF7 OCTANOYLTRANSFERASE OCTANOYL-[ACYL-CARRIER-PROTEIN]:PROTEIN N-OCTANOYLTRANSFERASE LIPT2, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 transferase#PC00220 Lipoate_biosynthesis#P02750>Lipoyl-protein ligase#P03003 HELRO|EnsemblGenome=HelroG190484|UniProtKB=T1FS11 T1FS11 20211608 PTHR33538:SF1 PROTEIN GAMETE EXPRESSED 1 PROTEIN BRAMBLEBERRY mitotic cell cycle process#GO:1903047;nuclear envelope organization#GO:0006998;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular component biogenesis#GO:0044085;single fertilization#GO:0007338;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;sexual reproduction#GO:0019953;nuclear division#GO:0000280;organelle fission#GO:0048285;membrane assembly#GO:0071709;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;fertilization#GO:0009566;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278 HELRO|EnsemblGenome=HelroG99764|UniProtKB=T1G9V1 T1G9V1 20217847 PTHR32465:SF0 BARDET-BIEDL SYNDROME 2 PROTEIN BBSOME COMPLEX MEMBER BBS2 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005;BBSome#GO:0034464;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG167648|UniProtKB=T1EZM1 T1EZM1 20202021 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG64937|UniProtKB=T1FY16 T1FY16 20213714 PTHR21347:SF14 CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED LIPID SCRAMBLASE CLPTM1-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG82208|UniProtKB=T1G4P2 T1G4P2 20216040 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG189343|UniProtKB=T1FQZ4 T1FQZ4 20211241 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG182807|UniProtKB=T1FIS3 T1FIS3 20208722 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161769|UniProtKB=T1ERW1 T1ERW1 20199311 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185279|UniProtKB=T1FML6 T1FML6 20210065 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cellular localization#GO:0051641;establishment of organelle localization#GO:0051656;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;localization#GO:0051179;organelle localization#GO:0051640;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;nucleus organization#GO:0006997;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;membrane organization#GO:0061024;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;protein localization to nucleus#GO:0034504;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG93853|UniProtKB=T1G8Y0 T1G8Y0 20217527 PTHR24413:SF240 SPECKLE-TYPE POZ PROTEIN PROTEIN ROADKILL ubiquitin protein ligase binding#GO:0031625;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185660|UniProtKB=T1FN37 T1FN37 20210235 PTHR23306:SF3 TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED TUMOR SUPPRESSOR PROTEIN 101 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;ESCRT I complex#GO:0000813;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG171760|UniProtKB=T1F4M0 T1F4M0 20203769 PTHR45749:SF43 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1-LIKE HELRO|EnsemblGenome=HelroG192836|UniProtKB=T1FUC4 T1FUC4 20212420 PTHR11089:SF9 GTP-BINDING PROTEIN-RELATED NUCLEOLAR GTP-BINDING PROTEIN 2 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG187554|UniProtKB=T1FPA7 T1FPA7 20210654 PTHR12746:SF2 NONSENSE-MEDIATED MRNA DECAY PROTEIN 3 60S RIBOSOMAL EXPORT PROTEIN NMD3 binding#GO:0005488;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;ribosomal large subunit binding#GO:0043023 cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;ribosome biogenesis#GO:0042254;organelle localization#GO:0051640;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit export from nucleus#GO:0000055;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;transport#GO:0006810;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG177721|UniProtKB=T1FC46 T1FC46 20206395 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165046|UniProtKB=T1EW70 T1EW70 20200820 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164974|UniProtKB=T1EW18 T1EW18 20200768 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110947|UniProtKB=T1EF65 T1EF65 20195217 PTHR11727:SF17 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL N-methyltransferase activity#GO:0008170;transcription regulator activity#GO:0140110;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;rRNA modification#GO:0000154;DNA-templated transcription initiation#GO:0006352;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;methylation#GO:0032259;macromolecule biosynthetic process#GO:0009059;mitochondrial transcription#GO:0006390;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;mitochondrial RNA metabolic process#GO:0000959;rRNA processing#GO:0006364;mitochondrial gene expression#GO:0140053 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG87902|UniProtKB=T1G6W5 T1G6W5 20216812 PTHR11669:SF9 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 5 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;replication fork#GO:0005657;nucleus#GO:0005634 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG187353|UniProtKB=T1FP92 T1FP92 20210639 PTHR46180:SF1 VINCULIN VINCULIN binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155 cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;organelle#GO:0043226;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;cell-cell contact zone#GO:0044291;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856 Gonadotropin-releasing hormone receptor pathway#P06664>Vinculin#P06771;Integrin signalling pathway#P00034>Vinculin#P00937 HELRO|EnsemblGenome=HelroG65985|UniProtKB=T1FYF6 T1FYF6 20213854 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043 neuron projection membrane#GO:0032589;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG173382|UniProtKB=T1F6R1 T1F6R1 20204510 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG169246|UniProtKB=T1F1M5 T1F1M5 20202725 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89821|UniProtKB=T1G7I0 T1G7I0 20217133 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG166458|UniProtKB=T1EY56 T1EY56 20201506 PTHR15326:SF2 SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC PROTEIN TAMOZHENNIC cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188811|UniProtKB=T1FQE1 T1FQE1 20211038 PTHR21551:SF0 TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1 PROTEIN ASSOCIATED WITH TOPO II RELATED - 1, ISOFORM A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;P-body assembly#GO:0033962;RNA decapping#GO:0110154;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;cellular component assembly#GO:0022607;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;organelle assembly#GO:0070925;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of translation#GO:0006417;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;P-body#GO:0000932;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG63495|UniProtKB=T1FXG5 T1FXG5 20213513 PTHR11537:SF294 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 metal ion transport#GO:0030001;action potential#GO:0001508;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810 dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;neuron projection terminus#GO:0044306;neuronal cell body#GO:0043025;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;axon terminus#GO:0043679;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;postsynaptic membrane#GO:0045211;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;postsynapse#GO:0098794;cell body#GO:0044297;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;synaptic membrane#GO:0097060;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell junction#GO:0030054;cell leading edge#GO:0031252;presynapse#GO:0098793;neuron projection#GO:0043005;protein-containing complex#GO:0032991 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG188680|UniProtKB=T1FQ89 T1FQ89 20210986 PTHR10807:SF133 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;dephosphorylation#GO:0016311 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG189549|UniProtKB=T1FR51 T1FR51 20211298 PTHR12019:SF9 LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN THYMOPOIETIN intercellular signal molecule#PC00207;peptide hormone#PC00179 HELRO|EnsemblGenome=HelroG91325|UniProtKB=T1G827 T1G827 20217224 PTHR19850:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020 heterotrimeric G-protein#PC00117;G-protein#PC00020;protein-binding activity modulator#PC00095 Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;PI3 kinase pathway#P00048>Gbetagamma#P01188;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458 HELRO|EnsemblGenome=HelroG115837|UniProtKB=T1EGB2 T1EGB2 20195614 PTHR12247:SF132 POLYCOMB GROUP PROTEIN POLYCOMB PROTEIN SCM protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG193978|UniProtKB=T1FVJ1 T1FVJ1 20212837 PTHR22722:SF14 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED MEGALIN, ISOFORM A hormone binding#GO:0042562;binding#GO:0005488 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG72832|UniProtKB=T1G160 T1G160 20214808 PTHR12777:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2 SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal snRNP assembly#GO:0000387;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 spliceosomal tri-snRNP complex#GO:0097526;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2 snRNP#GO:0005686;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;U4/U6 x U5 tri-snRNP complex#GO:0046540 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG175078|UniProtKB=T1F8T7 T1F8T7 20205236 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG194911|UniProtKB=T1FWK0 T1FWK0 20213195 PTHR11003:SF359 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182307|UniProtKB=T1FI12 T1FI12 20208461 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG192166|UniProtKB=T1FTN2 T1FTN2 20212179 PTHR46051:SF1 SH2 DOMAIN-CONTAINING PROTEIN PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASE regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG176178|UniProtKB=T1FA92 T1FA92 20205741 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74016|UniProtKB=T1G1L2 T1G1L2 20214960 PTHR43895:SF179 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE CHK1 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;mitotic cell cycle process#GO:1903047;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;intracellular signal transduction#GO:0035556;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG165453|UniProtKB=T1EWT9 T1EWT9 20201039 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG163385|UniProtKB=T1ETZ5 T1ETZ5 20200045 PTHR19297:SF192 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3-RELATED glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG165175|UniProtKB=T1EWD7 T1EWD7 20200887 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION HDC11342-RELATED regulation of mitotic cell cycle#GO:0007346;regulation of organelle assembly#GO:1902115;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of mitotic spindle assembly#GO:1901673;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of spindle organization#GO:0090224;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726;regulation of microtubule-based process#GO:0032886;regulation of spindle assembly#GO:0090169;regulation of mitotic spindle organization#GO:0060236 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG153339|UniProtKB=T1EL43 T1EL43 20197293 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162009|UniProtKB=T1ES53 T1ES53 20199403 PTHR48125:SF16 LP07818P1 UBZ4-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188320|UniProtKB=T1FPV4 T1FPV4 20210851 PTHR12854:SF7 ATAXIN 2-RELATED ATAXIN-2 HOMOLOG RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG165783|UniProtKB=T1EXA1 T1EXA1 20201201 PTHR11202:SF36 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER ACTIN NUCLEATION-PROMOTING FACTOR WASL cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Huntington disease#P00029>N-Wasp#P00769;Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525 HELRO|EnsemblGenome=HelroG168792|UniProtKB=T1F0Z2 T1F0Z2 20202492 PTHR20908:SF1 LD15586P LD15586P HELRO|EnsemblGenome=HelroG191278|UniProtKB=T1FSU2 T1FSU2 20211889 PTHR15128:SF0 TAL1 SCL INTERRUPTING LOCUS SCL-INTERRUPTING LOCUS PROTEIN protein localization to microtubule cytoskeleton#GO:0072698;biological regulation#GO:0065007;macromolecule localization#GO:0033036;spindle organization#GO:0007051;intracellular protein localization#GO:0008104;mitotic cell cycle process#GO:1903047;mitotic cell cycle#GO:0000278;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;protein localization to centrosome#GO:0071539;cellular response to stimulus#GO:0051716;localization#GO:0051179;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;smoothened signaling pathway#GO:0007224;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;signaling#GO:0023052;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;protein localization to microtubule organizing center#GO:1905508 intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG102672|UniProtKB=T1EDA9 T1EDA9 20194561 PTHR46028:SF2 KYNURENINE 3-MONOOXYGENASE KYNURENINE 3-MONOOXYGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709 membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185452|UniProtKB=T1FMU3 T1FMU3 20210142 PTHR10855:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;proteasome regulatory particle, lid subcomplex#GO:0008541;cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;proteasome complex#GO:0000502 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG190823|UniProtKB=T1FSB7 T1FSB7 20211714 PTHR23159:SF52 CENTROSOMAL PROTEIN 2 SUBFAMILY NOT NAMED chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG163650|UniProtKB=T1EUB5 T1EUB5 20200165 PTHR23103:SF17 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-LIKE PROTEIN 2 cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG169182|UniProtKB=T1F1J4 T1F1J4 20202694 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG194532|UniProtKB=T1FW59 T1FW59 20213055 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG66323|UniProtKB=T1FYJ8 T1FYJ8 20213896 PTHR43176:SF38 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;deacylase activity#GO:0160215;acyl-CoA hydrolase activity#GO:0016289 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG87607|UniProtKB=T1G6S9 T1G6S9 20216776 PTHR23506:SF45 GH10249P GH10249P solute:sodium symporter activity#GO:0015370;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;monoamine transmembrane transporter activity#GO:0008504;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297 transport#GO:0006810;synaptic vesicle cycle#GO:0099504;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular vesicle#GO:0097708;cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;axon#GO:0030424;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;neuron projection terminus#GO:0044306;intracellular membrane-bounded organelle#GO:0043231;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;organelle membrane#GO:0031090;axon terminus#GO:0043679;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658 secondary carrier transporter#PC00258;transporter#PC00227 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424 HELRO|EnsemblGenome=HelroG65067|UniProtKB=T1FY27 T1FY27 20213725 PTHR11071:SF602 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG169712|UniProtKB=T1F294 T1F294 20202944 PTHR13270:SF14 PROTEIN C20ORF116-RELATED SEX DETERMINATION AND DOSAGE COMPENSATION PROTEIN SDC-2 HELRO|EnsemblGenome=HelroG95088|UniProtKB=T1G944 T1G944 20217591 PTHR43880:SF12 ALCOHOL DEHYDROGENASE ALCOHOL DEHYDROGENASE CLASS-3 alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;zinc ion binding#GO:0008270;catalytic activity#GO:0003824;cation binding#GO:0043169;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;binding#GO:0005488;small molecule binding#GO:0036094 aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;aldehyde catabolic process#GO:0046185;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;response to chemical#GO:0042221;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;cellular detoxification of aldehyde#GO:0110095;small molecule catabolic process#GO:0044282;response to toxic substance#GO:0009636;catabolic process#GO:0009056;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG162218|UniProtKB=T1ESD2 T1ESD2 20199482 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG177789|UniProtKB=T1FC99 T1FC99 20206448 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG110145|UniProtKB=T1EEZ8 T1EEZ8 20195150 PTHR15574:SF21 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1 AND CUL4 ASSOCIATED FACTOR 8 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG63157|UniProtKB=T1FXB8 T1FXB8 20213466 PTHR15241:SF386 TRANSFORMER-2-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN-RELATED RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG109405|UniProtKB=T1EET5 T1EET5 20195087 PTHR11909:SF520 CASEIN KINASE-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>Casein kinase I#P01242;Wnt signaling pathway#P00057>Casein Kinase 1#P01460 HELRO|EnsemblGenome=HelroG75983|UniProtKB=T1G2D5 T1G2D5 20215233 PTHR22883:SF511 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein targeting#GO:0006605;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;developmental maturation#GO:0021700;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;synaptic vesicle maturation#GO:0016188;vesicle organization#GO:0016050;protein targeting to membrane#GO:0006612;developmental process#GO:0032502 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91140|UniProtKB=T1G801 T1G801 20217198 PTHR23418:SF0 ACIREDUCTONE DIOXYGENASE ACIREDUCTONE DIOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;carbohydrate derivative metabolic process#GO:1901135;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG69476|UniProtKB=T1FZV7 T1FZV7 20214355 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED INHIBITOR 1, PUTATIVE-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG74170|UniProtKB=T1G1M9 T1G1M9 20214977 PTHR42884:SF35 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 2 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;proteolysis#GO:0006508;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;cellular process#GO:0009987;peptide hormone processing#GO:0016486;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;hormone metabolic process#GO:0042445;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG164934|UniProtKB=T1EVZ5 T1EVZ5 20200745 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192484|UniProtKB=T1FU05 T1FU05 20212301 PTHR13271:SF163 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE ACTIN-HISTIDINE N-METHYLTRANSFERASE transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;lysine N-methyltransferase activity#GO:0016278 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185006|UniProtKB=T1FM97 T1FM97 20209946 PTHR46064:SF1 QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2 QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG175183|UniProtKB=T1F8Z1 T1F8Z1 20205290 PTHR23159:SF31 CENTROSOMAL PROTEIN 2 CENTROSOMAL PROTEIN 135KDA, ISOFORM B chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG68857|UniProtKB=T1FZK5 T1FZK5 20214253 PTHR12771:SF51 ENGULFMENT AND CELL MOTILITY LD01482P enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193726|UniProtKB=T1FVA6 T1FVA6 20212752 PTHR19303:SF82 TRANSPOSON HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG186165|UniProtKB=T1FNR3 T1FNR3 20210460 PTHR43450:SF1 ASPARTYL-TRNA SYNTHETASE ASPARTATE--TRNA LIGASE, CYTOPLASMIC RNA binding#GO:0003723;catalytic activity, acting on a tRNA#GO:0140101;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307 cytosol#GO:0005829;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG179156|UniProtKB=T1FE99 T1FE99 20207148 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;DNA exonuclease activity#GO:0004529;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;DNA endonuclease activity#GO:0004520;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518 DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 HELRO|EnsemblGenome=HelroG70072|UniProtKB=T1G022 T1G022 20214420 PTHR24343:SF457 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE STK11 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191984|UniProtKB=T1FTH6 T1FTH6 20212123 PTHR24016:SF21 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4 Golgi organization#GO:0007030;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;organelle organization#GO:0006996;retrograde transport, vesicle recycling within Golgi#GO:0000301;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COG complex#GO:0017119;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191670|UniProtKB=T1FT73 T1FT73 20212020 PTHR16284:SF13 PROTEIN CDV3 HOMOLOG PROTEIN CDV3 HOMOLOG cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166495|UniProtKB=T1EY64 T1EY64 20201514 PTHR10309:SF0 MANNOSE-6-PHOSPHATE ISOMERASE MANNOSE-6-PHOSPHATE ISOMERASE intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860 nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>Mannose 6-P isomerase#P03017 HELRO|EnsemblGenome=HelroG190326|UniProtKB=T1FRW9 T1FRW9 20211566 PTHR13561:SF20 DNA REPLICATION REGULATOR DPB11-RELATED DNA TOPOISOMERASE 2-BINDING PROTEIN 1 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG112012|UniProtKB=T1EFG4 T1EFG4 20195316 PTHR20933:SF4 F-BOX ONLY PROTEIN 33 F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A HELRO|EnsemblGenome=HelroG83299|UniProtKB=T1G538 T1G538 20216186 PTHR46485:SF4 LIM DOMAIN KINASE 1 LIM DOMAIN KINASE 1 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG192798|UniProtKB=T1FUB1 T1FUB1 20212407 PTHR19375:SF582 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein refolding#GO:0042026;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027;chaperone#PC00072 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG93833|UniProtKB=T1G8X8 T1G8X8 20217525 PTHR10869:SF244 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2 catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;dioxygenase activity#GO:0051213 intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;oxidoreductase complex#GO:1990204 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170223|UniProtKB=T1F2T1 T1F2T1 20203130 PTHR13582:SF0 M-PHASE PHOSPHOPROTEIN 6 M-PHASE PHOSPHOPROTEIN 6 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG99418|UniProtKB=T1G9S7 T1G9S7 20217823 PTHR13482:SF3 MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8 MICROPROCESSOR COMPLEX SUBUNIT DGCR8 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725 nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;primary miRNA processing#GO:0031053;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG86817|UniProtKB=T1G6H2 T1G6H2 20216669 PTHR47084:SF1 SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;ceramide metabolic process#GO:0006672 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185793|UniProtKB=T1FNA6 T1FNA6 20210303 PTHR11748:SF111 D-LACTATE DEHYDROGENASE D-LACTATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 small molecule catabolic process#GO:0044282;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG98030|UniProtKB=T1G9K1 T1G9K1 20217747 PTHR11267:SF212 T-BOX PROTEIN-RELATED LP04777P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 heart development#GO:0007507;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;cell fate specification#GO:0001708;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cell fate commitment#GO:0045165;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG122772|UniProtKB=T1EGV8 T1EGV8 20195808 PTHR12210:SF202 DULLARD PROTEIN PHOSPHATASE PHOSPHATASE HERZOG hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG184119|UniProtKB=T1FKM2 T1FKM2 20209371 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG115941|UniProtKB=T1EGB9 T1EGB9 20195621 PTHR12317:SF0 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG67240|UniProtKB=T1FYY7 T1FYY7 20214035 PTHR45673:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED hydrolase activity#GO:0016787;protein binding#GO:0005515;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;calcineurin-mediated signaling#GO:0097720;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287 protein phosphatase#PC00195 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG179002|UniProtKB=T1FE14 T1FE14 20207063 PTHR31395:SF25 SHISA PROTEIN SHISA-5-LIKE ISOFORM X1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176573|UniProtKB=T1FAN9 T1FAN9 20205888 PTHR35258:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 22 SPERMATOGENESIS-ASSOCIATED PROTEIN 22 regulation of reproductive process#GO:2000241;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of meiotic cell cycle#GO:0051445;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG169779|UniProtKB=T1F2B4 T1F2B4 20202964 PTHR19964:SF97 MULTIPLE PDZ DOMAIN PROTEIN PDZ DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192915|UniProtKB=T1FUF3 T1FUF3 20212449 PTHR24107:SF2 YNEIN REGULATORY COMPLEX SUBUNIT 5 NLR FAMILY CARD DOMAIN CONTAINING 3 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG151168|UniProtKB=T1EKI6 T1EKI6 20197086 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG80480|UniProtKB=T1G415 T1G415 20215813 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987 sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;cytoplasm#GO:0005737;sarcoplasmic reticulum membrane#GO:0033017;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;sarcoplasm#GO:0016528;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG99776|UniProtKB=T1G9V2 T1G9V2 20217848 PTHR10502:SF239 ANNEXIN ANNEXIN A7 phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;phospholipid binding#GO:0005543;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;nucleus#GO:0005634;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG157435|UniProtKB=T1EMB4 T1EMB4 20197714 PTHR10466:SF0 PHOSPHOMANNOMUTASE PHOSPHOMANNOMUTASE intramolecular phosphotransferase activity#GO:0016868;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;isomerase activity#GO:0016853 glycoprotein metabolic process#GO:0009100;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 mutase#PC00160;metabolite interconversion enzyme#PC00262;isomerase#PC00135 Mannose metabolism#P02752>P-Mannose mutase#P03019 HELRO|EnsemblGenome=HelroG167361|UniProtKB=T1EZA9 T1EZA9 20201909 PTHR23334:SF69 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN GAMMA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG189261|UniProtKB=T1FQV9 T1FQV9 20211206 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315 regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG107695|UniProtKB=T1EEC3 T1EEC3 20194925 PTHR13848:SF2 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG156264|UniProtKB=T1ELT6 T1ELT6 20197536 PTHR12241:SF31 TUBULIN POLYGLUTAMYLASE POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1 catalytic activity, acting on a protein#GO:0140096;tubulin binding#GO:0015631;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;binding#GO:0005488 sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870;developmental process#GO:0032502;spermatogenesis#GO:0007283;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;sperm axoneme assembly#GO:0007288;cellular developmental process#GO:0048869;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;spermatid differentiation#GO:0048515;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;sperm motility#GO:0097722;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;microtubule-based process#GO:0007017;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG87141|UniProtKB=T1G6M2 T1G6M2 20216719 PTHR10634:SF67 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 3 HELRO|EnsemblGenome=HelroG67859|UniProtKB=T1FZ64 T1FZ64 20214112 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170638|UniProtKB=T1F398 T1F398 20203297 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED translation regulator activity#GO:0045182 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG151206|UniProtKB=T1EKI7 T1EKI7 20197087 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG186129|UniProtKB=T1FNP8 T1FNP8 20210445 PTHR10758:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056 endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;proteasome complex#GO:0000502;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG178909|UniProtKB=T1FDV9 T1FDV9 20207008 PTHR13546:SF15 RE60986P CCDC85 HELRO|EnsemblGenome=HelroG131725|UniProtKB=T1EHW4 T1EHW4 20196164 PTHR24056:SF400 CELL DIVISION PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70726|UniProtKB=T1G0B2 T1G0B2 20214510 PTHR13329:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S18B SMALL RIBOSOMAL SUBUNIT PROTEIN MS40 ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG100558|UniProtKB=T1ED04 T1ED04 20194456 PTHR23150:SF37 SULFATASE MODIFYING FACTOR 1, 2 FORMYLGLYCINE-GENERATING ENZYME oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG190036|UniProtKB=T1FRM1 T1FRM1 20211468 PTHR23327:SF42 RING FINGER PROTEIN 127 LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82191|UniProtKB=T1G4P0 T1G4P0 20216038 PTHR12619:SF5 RFX TRANSCRIPTION FACTOR FAMILY RFX, ISOFORM H transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG186046|UniProtKB=T1FNL3 T1FNL3 20210410 PTHR45619:SF8 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;protein phosphatase#PC00195 FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG115505|UniProtKB=T1EG88 T1EG88 20195590 PTHR23512:SF13 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 LYSOSOMAL DIPEPTIDE TRANSPORTER MFSD1 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG189990|UniProtKB=T1FRK4 T1FRK4 20211451 PTHR23138:SF142 RAN BINDING PROTEIN RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 2 protein export from nucleus#GO:0006611;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;nuclear export#GO:0051168;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178626|UniProtKB=T1FDG9 T1FDG9 20206868 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG190413|UniProtKB=T1FRZ1 T1FRZ1 20211588 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG82466|UniProtKB=T1G4S6 T1G4S6 20216074 PTHR45712:SF36 AGAP008170-PA PODOCAN ISOFORM X1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG98278|UniProtKB=T1G9L7 T1G9L7 20217763 PTHR24412:SF491 KELCH PROTEIN KELCH-LIKE PROTEIN 20 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 Apoptosis signaling pathway#P00006>Smac/Diablo#P00309 HELRO|EnsemblGenome=HelroG157531|UniProtKB=T1EMC6 T1EMC6 20197726 PTHR10507:SF0 CDC45-RELATED PROTEIN CELL DIVISION CONTROL PROTEIN 45 HOMOLOG chromatin binding#GO:0003682;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization#GO:0016043;response to stimulus#GO:0050896;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;metabolic process#GO:0008152;mitotic DNA replication#GO:1902969;nuclear DNA replication#GO:0033260;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;recombinational repair#GO:0000725;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitotic cell cycle#GO:0000278;DNA damage response#GO:0006974;DNA repair#GO:0006281;cell cycle DNA replication#GO:0044786;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;double-strand break repair via break-induced replication#GO:0000727;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA replication preinitiation complex#GO:0031261;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG103068|UniProtKB=T1EDE1 T1EDE1 20194593 PTHR10953:SF186 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6 ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG180499|UniProtKB=T1FFZ7 T1FFZ7 20207746 PTHR21580:SF28 SHIPPO-1-RELATED SPERM-TAIL PG-RICH REPEAT FAMILY PROTEIN intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 structural protein#PC00211 HELRO|EnsemblGenome=HelroG62093|UniProtKB=T1FWV6 T1FWV6 20213304 PTHR21011:SF17 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;structural molecule activity#GO:0005198;RNA binding#GO:0003723 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG70090|UniProtKB=T1G027 T1G027 20214425 PTHR13720:SF18 WD-40 REPEAT PROTEIN FI23230P1 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG71671|UniProtKB=T1G0Q0 T1G0Q0 20214648 PTHR43788:SF16 DNA2/NAM7 HELICASE FAMILY MEMBER 3'-5' EXORIBONUCLEASE HELZ2 ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stress#GO:0006950 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG158228|UniProtKB=T1EMK9 T1EMK9 20197809 PTHR24098:SF0 OUTER SEGMENT 5 OUTER SEGMENT 5 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intraciliary transport particle#GO:0030990;cilium#GO:0005929;intraciliary transport particle B#GO:0030992;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG169361|UniProtKB=T1F1U4 T1F1U4 20202794 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG195146|UniProtKB=T1FWT1 T1FWT1 20213276 PTHR31954:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 structural protein#PC00211 HELRO|EnsemblGenome=HelroG174839|UniProtKB=T1F8I9 T1F8I9 20205138 PTHR18905:SF13 NINEIN NINEIN HOMOLOG cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;microtubule anchoring at microtubule organizing center#GO:0072393;cellular component organization or biogenesis#GO:0071840;microtubule anchoring#GO:0034453;microtubule cytoskeleton organization#GO:0000226 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183411|UniProtKB=T1FJL3 T1FJL3 20209012 PTHR23275:SF100 CABRIOLET.-RELATED SURFACE ANTIGEN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG93044|UniProtKB=T1G8R7 T1G8R7 20217464 PTHR34410:SF2 INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED HELRO|EnsemblGenome=HelroG89960|UniProtKB=T1G7J7 T1G7J7 20217044 PTHR43982:SF1 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14 catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;binding#GO:0005488;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;protein-containing complex binding#GO:0044877 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of catabolic process#GO:0009894;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of ERAD pathway#GO:1904292;negative regulation of proteasomal protein catabolic process#GO:1901799;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of cellular response to stress#GO:0080135 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG176714|UniProtKB=T1FAT5 T1FAT5 20205934 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG125752|UniProtKB=T1EH73 T1EH73 20195923 PTHR11266:SF8 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MPV17-LIKE PROTEIN 2 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG77812|UniProtKB=T1G344 T1G344 20215492 PTHR10663:SF412 GUANYL-NUCLEOTIDE EXCHANGE FACTOR GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840 Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;Golgi cisterna#GO:0031985;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG153341|UniProtKB=T1EL45 T1EL45 20197295 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74301|UniProtKB=T1G1P5 T1G1P5 20214993 PTHR24112:SF66 LEUCINE-RICH REPEAT, ISOFORM F-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37 HOMOLOG regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell migration#GO:0016477;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493 cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG175883|UniProtKB=T1F9T9 T1F9T9 20205588 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163509|UniProtKB=T1EU55 T1EU55 20200105 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185599|UniProtKB=T1FN08 T1FN08 20210207 PTHR24155:SF10 OSTEOCLAST-STIMULATING FACTOR 1 OSTEOCLAST-STIMULATING FACTOR 1 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 HELRO|EnsemblGenome=HelroG87495|UniProtKB=T1G6R0 T1G6R0 20216757 PTHR12951:SF1 RETINAL PROTEIN 4 PROTEIN UNC-119 HOMOLOG lipid binding#GO:0008289;binding#GO:0005488 transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cell projection assembly#GO:0030031;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;cilium organization#GO:0044782;protein transport#GO:0015031;localization#GO:0051179;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG179908|UniProtKB=T1FF88 T1FF88 20207487 PTHR31802:SF53 32 KDA HEAT SHOCK PROTEIN-RELATED SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183621|UniProtKB=T1FJY2 T1FJY2 20209131 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181042|UniProtKB=T1FGK0 T1FGK0 20207949 PTHR33137:SF53 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED SUBFAMILY NOT NAMED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG181925|UniProtKB=T1FHG7 T1FHG7 20208266 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG113191|UniProtKB=T1EFQ7 T1EFQ7 20195409 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG81669|UniProtKB=T1G4H1 T1G4H1 20215969 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG185468|UniProtKB=T1FMU9 T1FMU9 20210148 PTHR18945:SF914 NEUROTRANSMITTER GATED ION CHANNEL NEUROTRANSMITTER-GATED ION-CHANNEL LIGAND-BINDING DOMAIN-CONTAINING PROTEIN trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG91314|UniProtKB=T1G824 T1G824 20217221 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG68641|UniProtKB=T1FZH5 T1FZH5 20214223 PTHR42825:SF7 AMINO ACID AMINOTRANSFERASE BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE transaminase activity#GO:0008483;catalytic activity#GO:0003824;transferase activity#GO:0016740 transferase#PC00220;transaminase#PC00216 HELRO|EnsemblGenome=HelroG81646|UniProtKB=T1G4G9 T1G4G9 20215967 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG185496|UniProtKB=T1FMW2 T1FMW2 20210161 PTHR19317:SF0 PRENYLATED RAB ACCEPTOR 1-RELATED PRENYLATED RAB ACCEPTOR PROTEIN 1 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170840|UniProtKB=T1F3I0 T1F3I0 20203379 PTHR13155:SF1 A-KINASE ANCHOR PROTEINS A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG71432|UniProtKB=T1G0L5 T1G0L5 20214613 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG124058|UniProtKB=T1EH00 T1EH00 20195850 PTHR10127:SF780 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING METALLOENDOPEPTIDASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG160318|UniProtKB=T1EQ32 T1EQ32 20198682 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180956|UniProtKB=T1FGG6 T1FGG6 20207915 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG184872|UniProtKB=T1FM39 T1FM39 20209888 PTHR10766:SF41 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3 localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;localization within membrane#GO:0051668;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG85168|UniProtKB=T1G5T7 T1G5T7 20216434 PTHR31398:SF0 MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG homologous recombination#GO:0035825;reproductive process#GO:0022414;cell cycle#GO:0007049;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;nucleobase-containing compound metabolic process#GO:0006139;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG169900|UniProtKB=T1F2F3 T1F2F3 20203003 PTHR24388:SF118 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 507 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG167133|UniProtKB=T1EZ24 T1EZ24 20201824 PTHR35936:SF19 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F AMINO-ACID-BINDING PROTEIN YXEM-RELATED HELRO|EnsemblGenome=HelroG82006|UniProtKB=T1G4L7 T1G4L7 20216015 PTHR13387:SF9 PROTEIN HGH1 HOMOLOG CO-CHAPERONE PROTEIN HGH1 HOMOLOG HELRO|EnsemblGenome=HelroG79604|UniProtKB=T1G3Q7 T1G3Q7 20215705 PTHR22894:SF5 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF170 HELRO|EnsemblGenome=HelroG185290|UniProtKB=T1FMM1 T1FMM1 20210070 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT oxidoreductase activity#GO:0016491;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 cellular process#GO:0009987;metabolic process#GO:0008152;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;cytosol#GO:0005829;oxidoreductase complex#GO:1990204 oxidoreductase#PC00176;reductase#PC00198 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo purine biosynthesis#P02738>GDP reductase#P02909;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921 HELRO|EnsemblGenome=HelroG71226|UniProtKB=T1G0I0 T1G0I0 20214578 PTHR10605:SF72 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG140872|UniProtKB=T1EJ19 T1EJ19 20196569 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG111661|UniProtKB=T1EFD3 T1EFD3 20195285 PTHR23308:SF66 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 KANADAPTIN molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG71857|UniProtKB=T1G0S4 T1G0S4 20214672 PTHR22951:SF115 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;clathrin binding#GO:0030276;SNARE binding#GO:0000149;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167 transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;receptor-mediated endocytosis#GO:0006898;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;membrane organization#GO:0061024 coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;extrinsic component of plasma membrane#GO:0019897;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;clathrin-coated vesicle#GO:0030136;synaptic membrane#GO:0097060;endomembrane system#GO:0012505;transport vesicle#GO:0030133;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;presynapse#GO:0098793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG82276|UniProtKB=T1G4P9 T1G4P9 20216047 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG191484|UniProtKB=T1FT10 T1FT10 20211957 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG94088|UniProtKB=T1G8Z0 T1G8Z0 20217537 PTHR13382:SF67 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B F-BOX AND LEUCINE RICH REPEAT PROTEIN 20 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 cytoplasm#GO:0005737;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG182427|UniProtKB=T1FI65 T1FI65 20208514 PTHR22950:SF349 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;cellular process#GO:0009987;transport#GO:0006810;amino acid transport#GO:0006865 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;vacuolar membrane#GO:0005774;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HELRO|EnsemblGenome=HelroG157245|UniProtKB=T1EM87 T1EM87 20197687 PTHR10562:SF56 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER enzyme binding#GO:0019899;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;protein binding#GO:0005515 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein sumoylation#GO:0016925 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG107343|UniProtKB=T1EE97 T1EE97 20194899 PTHR10653:SF0 F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of actin filament depolymerization#GO:0030834;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of protein depolymerization#GO:1901879;regulation of actin filament organization#GO:0110053;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component organization#GO:0051128;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG113524|UniProtKB=T1EFT1 T1EFT1 20195433 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG164159|UniProtKB=T1EV07 T1EV07 20200407 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95830|UniProtKB=T1G979 T1G979 20217626 PTHR22726:SF1 METALLOENDOPEPTIDASE OMA1 METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;cellular process#GO:0009987;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG171864|UniProtKB=T1F4S4 T1F4S4 20203823 PTHR10527:SF5 IMPORTIN BETA IMPORTIN-5 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG187007|UniProtKB=T1FP55 T1FP55 20210602 PTHR11629:SF114 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;enzyme binding#GO:0019899;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG183857|UniProtKB=T1FK99 T1FK99 20209248 PTHR31742:SF1 RPA-INTERACTING PROTEIN RPAIN RPA-INTERACTING PROTEIN nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG173904|UniProtKB=T1F7C6 T1F7C6 20204725 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG183518|UniProtKB=T1FJS2 T1FJS2 20209071 PTHR21084:SF1 DENSE INCISORS SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 38 HELRO|EnsemblGenome=HelroG82586|UniProtKB=T1G4U1 T1G4U1 20216089 PTHR24416:SF609 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178273|UniProtKB=T1FD07 T1FD07 20206706 PTHR36694:SF12 PASIFLORA 1, ISOFORM A-RELATED ZINC FINGER PROTEIN HELRO|EnsemblGenome=HelroG193461|UniProtKB=T1FV06 T1FV06 20212652 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG172456|UniProtKB=T1F5C5 T1F5C5 20204024 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG191851|UniProtKB=T1FTC7 T1FTC7 20212074 PTHR14516:SF6 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER MULTIFUNCTIONAL FUSION PROTEIN oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG178238|UniProtKB=T1FCZ5 T1FCZ5 20206694 PTHR13484:SF10 FIP1-LIKE 1 PROTEIN SUBFAMILY NOT NAMED intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG178553|UniProtKB=T1FDD1 T1FDD1 20206830 PTHR46927:SF4 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG65462|UniProtKB=T1FY81 T1FY81 20213779 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179740|UniProtKB=T1FF37 T1FF37 20207436 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172857|UniProtKB=T1F609 T1F609 20204258 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG143271|UniProtKB=T1EJ98 T1EJ98 20196648 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG86281|UniProtKB=T1G698 T1G698 20216595 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG63739|UniProtKB=T1FXJ4 T1FXJ4 20213542 PTHR10024:SF369 SYNAPTOTAGMIN FI18813P1 protein binding#GO:0005515;molecular sensor activity#GO:0140299;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component organization#GO:0051128;positive regulation of cellular component organization#GO:0051130;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;vesicle fusion#GO:0006906;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;regulation of exocytosis#GO:0017157;localization#GO:0051179;regulation of secretion#GO:0051046;cell communication#GO:0007154;secretion#GO:0046903;positive regulation of cellular process#GO:0048522;membrane fusion#GO:0061025;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;membrane organization#GO:0061024;neurotransmitter secretion#GO:0007269;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;axon#GO:0030424;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG108226|UniProtKB=T1EEH2 T1EEH2 20194974 PTHR12858:SF1 RIBOSOME BIOGENESIS PROTEIN PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467 intracellular organelle#GO:0043229;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG179864|UniProtKB=T1FF79 T1FF79 20207478 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185579|UniProtKB=T1FN01 T1FN01 20210200 PTHR15184:SF88 ATP SYNTHASE ATP SYNTHASE F(1) COMPLEX SUBUNIT BETA, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;proton channel activity#GO:0015252;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933 oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;generation of precursor metabolites and energy#GO:0006091;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP biosynthetic process#GO:0006754;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987 proton-transporting ATP synthase complex#GO:0045259;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane protein complex#GO:0098796;membrane#GO:0016020;respiratory chain complex#GO:0098803;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002 ATP synthesis#P02721>F1 beta#P02794 HELRO|EnsemblGenome=HelroG165012|UniProtKB=T1EW47 T1EW47 20200797 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161003|UniProtKB=T1EQZ8 T1EQZ8 20198998 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG159340|UniProtKB=T1ENX0 T1ENX0 20198270 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG86284|UniProtKB=T1G699 T1G699 20216596 PTHR23147:SF245 SERINE/ARGININE RICH SPLICING FACTOR CCHC-TYPE DOMAIN-CONTAINING PROTEIN nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG124905|UniProtKB=T1EH34 T1EH34 20195884 PTHR21377:SF1 PROTEIN FAM210B, MITOCHONDRIAL MITOCHONDRIAL INNER MEMBRANE SCAFFOLD 1 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG185931|UniProtKB=T1FNG2 T1FNG2 20210359 PTHR21433:SF0 TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA TRANSMEMBRANE PROTEIN 120 HOMOLOG nuclear membrane#GO:0031965;nuclear inner membrane#GO:0005637;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;nucleus#GO:0005634;organelle inner membrane#GO:0019866 HELRO|EnsemblGenome=HelroG190143|UniProtKB=T1FRQ4 T1FRQ4 20211501 PTHR42884:SF38 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;hormone metabolic process#GO:0042445;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;DPP signaling pathway#P06213>FUR1#P06290;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Activin beta signaling pathway#P06210>FUR1#P06238;DPP-SCW signaling pathway#P06212>FUR1#P06263;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;Endothelin signaling pathway#P00019>furin#P00575;MYO signaling pathway#P06215>FUR1#P06318;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG153392|UniProtKB=T1EL66 T1EL66 20197316 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG129966|UniProtKB=T1EHS8 T1EHS8 20196128 PTHR43671:SF105 SERINE/THREONINE-PROTEIN KINASE NEK SERINE_THREONINE-PROTEIN KINASE NEK8 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG167462|UniProtKB=T1EZE5 T1EZE5 20201945 PTHR11913:SF122 COFILIN-RELATED COFILIN_ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;actin filament depolymerization#GO:0030042;cellular component organization#GO:0016043;organelle organization#GO:0006996;protein depolymerization#GO:0051261;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component disassembly#GO:0022411;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG172478|UniProtKB=T1F5D5 T1F5D5 20204034 PTHR44809:SF2 DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE HELRO|EnsemblGenome=HelroG93491|UniProtKB=T1G8W0 T1G8W0 20217507 PTHR43766:SF5 TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 translation#GO:0006412;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG181307|UniProtKB=T1FGV7 T1FGV7 20208056 PTHR31718:SF60 PLAT DOMAIN-CONTAINING PROTEIN LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG180677|UniProtKB=T1FG57 T1FG57 20207806 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171050|UniProtKB=T1F3R2 T1F3R2 20203461 PTHR47086:SF4 BTB DOMAIN-CONTAINING PROTEIN BTB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188699|UniProtKB=T1FQ98 T1FQ98 20210995 PTHR31179:SF7 RAB GTPASE-BINDING EFFECTOR PROTEIN RAB GTPASE-BINDING EFFECTOR PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157319|UniProtKB=T1EM96 T1EM96 20197696 PTHR24256:SF576 TRYPTASE-RELATED IP10114P-RELATED catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG78435|UniProtKB=T1G3B7 T1G3B7 20215565 PTHR19957:SF307 SYNTAXIN SYNTAXIN-1A SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;protein transport#GO:0015031;secretion by cell#GO:0032940;vesicle fusion#GO:0006906;export from cell#GO:0140352;cellular component organization#GO:0016043 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066 HELRO|EnsemblGenome=HelroG188809|UniProtKB=T1FQD9 T1FQD9 20211036 PTHR44176:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 25 DNAJ HOMOLOG SUBFAMILY C MEMBER 25 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184986|UniProtKB=T1FM83 T1FM83 20209932 PTHR23291:SF133 BAX INHIBITOR-RELATED BAX INHIBITOR 1 enzyme regulator activity#GO:0030234;calcium ion transmembrane transporter activity#GO:0015085;molecular function inhibitor activity#GO:0140678;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium channel activity#GO:0005262;enzyme inhibitor activity#GO:0004857;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;metal ion transmembrane transporter activity#GO:0046873 cellular response to topologically incorrect protein#GO:0035967;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of apoptotic signaling pathway#GO:2001234;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;response to unfolded protein#GO:0006986;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of cell communication#GO:0010646;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 ion channel#PC00133;transporter#PC00227 Apoptosis signaling pathway#P00006>Bi1#P00277 HELRO|EnsemblGenome=HelroG62538|UniProtKB=T1FX20 T1FX20 20213368 PTHR46377:SF1 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of MAPK cascade#GO:0043408;regulation of JNK cascade#GO:0046328 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG82671|UniProtKB=T1G4V1 T1G4V1 20216099 PTHR46154:SF4 FAMILY NOT NAMED UREA TRANSPORTER HELRO|EnsemblGenome=HelroG72380|UniProtKB=T1G0Z2 T1G0Z2 20214740 PTHR20961:SF148 GLYCOSYLTRANSFERASE EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG167539|UniProtKB=T1EZG8 T1EZG8 20201968 PTHR15492:SF1 CYCLIN D1-BINDING PROTEIN 1 CYCLIN-D1-BINDING PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG189133|UniProtKB=T1FQP8 T1FQP8 20211145 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG103086|UniProtKB=T1EDE2 T1EDE2 20194594 PTHR10763:SF23 CELL DIVISION CONTROL PROTEIN 6-RELATED ORIGIN RECOGNITION COMPLEX SUBUNIT 1 DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA replication initiation#GO:0006270;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260;nucleobase-containing compound metabolic process#GO:0006139 origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nuclear origin of replication recognition complex#GO:0005664;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;chromosome#GO:0005694 replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG176190|UniProtKB=T1FAA1 T1FAA1 20205750 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91152|UniProtKB=T1G804 T1G804 20217201 PTHR23050:SF536 CALCIUM BINDING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG161317|UniProtKB=T1ERB9 T1ERB9 20199119 PTHR11388:SF157 ORGANIC ANION TRANSPORTER ORGANIC ANION TRANSPORTING POLYPEPTIDE 30B, ISOFORM A active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG169856|UniProtKB=T1F2D6 T1F2D6 20202986 PTHR23040:SF1 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG168879|UniProtKB=T1F133 T1F133 20202533 PTHR15528:SF11 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED FI18188P1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;multicellular organismal-level homeostasis#GO:0048871;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;homeostatic process#GO:0042592 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG64117|UniProtKB=T1FXP7 T1FXP7 20213595 PTHR21016:SF4 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of Notch signaling pathway#GO:0045747;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165 HELRO|EnsemblGenome=HelroG70039|UniProtKB=T1G018 T1G018 20214416 PTHR22760:SF1 GLYCOSYLTRANSFERASE DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG167021|UniProtKB=T1EYW7 T1EYW7 20201767 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG183443|UniProtKB=T1FJN8 T1FJN8 20209037 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162928|UniProtKB=T1ETD2 T1ETD2 20199832 PTHR17039:SF0 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;90S preribosome#GO:0030686;small-subunit processome#GO:0032040;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG65229|UniProtKB=T1FY48 T1FY48 20213746 PTHR23076:SF144 METALLOPROTEASE M41 FTSH ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1 peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG169067|UniProtKB=T1F1C8 T1F1C8 20202628 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG101948|UniProtKB=T1ED76 T1ED76 20194528 PTHR11732:SF506 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE 1B-RELATED oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG193588|UniProtKB=T1FV53 T1FV53 20212699 PTHR12809:SF2 MEDIATOR COMPLEX SUBUNIT MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG165267|UniProtKB=T1EWI8 T1EWI8 20200938 PTHR40240:SF1 PLEXUS, ISOFORM A PLEXUS, ISOFORM A HELRO|EnsemblGenome=HelroG189512|UniProtKB=T1FR42 T1FR42 20211289 PTHR23423:SF21 ORGANIC SOLUTE TRANSPORTER-RELATED ORGANIC SOLUTE TRANSPORTER SUBUNIT ALPHA transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG156367|UniProtKB=T1ELU4 T1ELU4 20197544 PTHR43977:SF2 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN HELRO|EnsemblGenome=HelroG107032|UniProtKB=T1EE66 T1EE66 20194868 PTHR24073:SF1216 DRAB5-RELATED RAS-RELATED PROTEIN RAB-5C hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG174401|UniProtKB=T1F830 T1F830 20204979 PTHR21026:SF2 39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG98522|UniProtKB=T1G9N4 T1G9N4 20217780 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME-RELATED membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metalloprotease#PC00153;protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG112580|UniProtKB=T1EFK8 T1EFK8 20195360 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 HELRO|EnsemblGenome=HelroG97167|UniProtKB=T1G9F7 T1G9F7 20217704 PTHR24056:SF599 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 11A-RELATED catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG139196|UniProtKB=T1EIY3 T1EIY3 20196533 PTHR11347:SF198 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE, ISOFORM I hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG159791|UniProtKB=T1EPE8 T1EPE8 20198448 PTHR12901:SF10 SPERM PROTEIN HOMOLOG COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG185474|UniProtKB=T1FMV2 T1FMV2 20210151 PTHR11835:SF34 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;alcohol metabolic process#GO:0006066;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 oxidoreductase#PC00176;dehydrogenase#PC00092 Leucine biosynthesis#P02749>3-Isopropylmalate dehydrogenase#P03001 HELRO|EnsemblGenome=HelroG183498|UniProtKB=T1FJR7 T1FJR7 20209066 PTHR48017:SF206 OS05G0424000 PROTEIN-RELATED VESICULAR INHIBITORY AMINO ACID TRANSPORTER amino acid transmembrane transporter activity#GO:0015171;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;neutral L-amino acid transmembrane transporter activity#GO:0015175;glycine transmembrane transporter activity#GO:0015187 glycine transport#GO:0015816;localization#GO:0051179;cellular localization#GO:0051641;neutral amino acid transport#GO:0015804;carboxylic acid transport#GO:0046942;transport#GO:0006810;amino acid transport#GO:0006865;synaptic vesicle cycle#GO:0099504;organic acid transport#GO:0015849;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192 cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular vesicle#GO:0097708;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;neuron projection terminus#GO:0044306 HELRO|EnsemblGenome=HelroG163274|UniProtKB=T1ETV1 T1ETV1 20200001 PTHR14939:SF5 F-BOX ONLY PROTEIN 22 FIST C-DOMAIN DOMAIN-CONTAINING PROTEIN enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 catalytic complex#GO:1902494;transferase complex#GO:1990234;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG189100|UniProtKB=T1FQN2 T1FQN2 20211129 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG122869|UniProtKB=T1EGW2 T1EGW2 20195812 PTHR24228:SF59 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR NEUROPEPTIDE RECEPTOR 15 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG77494|UniProtKB=T1G2Y6 T1G2Y6 20215434 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159957|UniProtKB=T1EPL5 T1EPL5 20198515 PTHR46600:SF15 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG176020|UniProtKB=T1FA11 T1FA11 20205660 PTHR24381:SF486 ZINC FINGER PROTEIN ADULT ENHANCER FACTOR 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG179569|UniProtKB=T1FEW0 T1FEW0 20207359 PTHR43104:SF2 L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG171907|UniProtKB=T1F4T8 T1F4T8 20203837 PTHR10725:SF73 THAP DOMAIN-CONTAINING PROTEIN 9 APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90755|UniProtKB=T1G7V8 T1G7V8 20217155 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG182583|UniProtKB=T1FIE6 T1FIE6 20208595 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG193337|UniProtKB=T1FUW3 T1FUW3 20212609 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106126|UniProtKB=T1EE03 T1EE03 20194805 PTHR42861:SF102 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG78040|UniProtKB=T1G371 T1G371 20215519 PTHR23129:SF0 ACYL-COENZYME A DIPHOSPHATASE FITM2 ACYL-COENZYME A DIPHOSPHATASE FITM2 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;organelle assembly#GO:0070925;lipid droplet organization#GO:0034389;homeostatic process#GO:0042592;cellular component assembly#GO:0022607;lipid storage#GO:0019915;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;lipid homeostasis#GO:0055088;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG108181|UniProtKB=T1EEG4 T1EEG4 20194966 PTHR45711:SF12 CHLORIDE CHANNEL PROTEIN CHLORIDE CHANNEL PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509 cellular process#GO:0009987;renal system process#GO:0003014;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;system process#GO:0003008;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG168519|UniProtKB=T1F0N5 T1F0N5 20202385 PTHR11652:SF1 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;ribosome#GO:0005840;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG96051|UniProtKB=T1G999 T1G999 20217646 PTHR22950:SF349 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943 amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;localization#GO:0051179 vacuolar membrane#GO:0005774;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG159775|UniProtKB=T1EPE2 T1EPE2 20198442 PTHR34349:SF1 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32 STABILIZER OF AXONEMAL MICROTUBULES 4 enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;protein binding#GO:0005515 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG168706|UniProtKB=T1F0V6 T1F0V6 20202456 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG192219|UniProtKB=T1FTQ3 T1FTQ3 20212200 PTHR11683:SF12 MYELIN PROTEOLIPID M6, ISOFORM F anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;neuron projection development#GO:0031175;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 myelin protein#PC00161 HELRO|EnsemblGenome=HelroG185875|UniProtKB=T1FND8 T1FND8 20210335 PTHR43561:SF3 FAMILY NOT NAMED HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 HELRO|EnsemblGenome=HelroG191874|UniProtKB=T1FTD6 T1FTD6 20212083 PTHR15435:SF3 KICSTOR COMPLEX PROTEIN KAPTIN SOCS BOX DOMAIN-CONTAINING PROTEIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 HELRO|EnsemblGenome=HelroG174718|UniProtKB=T1F8E5 T1F8E5 20205094 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184825|UniProtKB=T1FM20 T1FM20 20209869 PTHR23073:SF7 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 6A isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;proteasome complex#GO:0000502 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG73543|UniProtKB=T1G1F7 T1G1F7 20214905 PTHR12413:SF1 DOLICHYL GLYCOSYLTRANSFERASE DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527 protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG180058|UniProtKB=T1FFF0 T1FFF0 20207549 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG159813|UniProtKB=T1EPF4 T1EPF4 20198454 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86834|UniProtKB=T1G6H8 T1G6H8 20216675 PTHR10159:SF528 DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;signal transduction#GO:0007165 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG153197|UniProtKB=T1EL07 T1EL07 20197257 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174936|UniProtKB=T1F8M8 T1F8M8 20205177 PTHR13108:SF9 CONDENSIN COMPLEX SUBUNIT 2 CONDENSIN COMPLEX SUBUNIT 2 chromatin binding#GO:0003682;binding#GO:0005488 organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;nuclear division#GO:0000280;organelle fission#GO:0048285;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076 condensin complex#GO:0000796;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG178489|UniProtKB=T1FD90 T1FD90 20206789 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG193024|UniProtKB=T1FUJ2 T1FUJ2 20212488 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG65728|UniProtKB=T1FYC0 T1FYC0 20213818 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG185422|UniProtKB=T1FMT0 T1FMT0 20210129 PTHR19877:SF1 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I binding#GO:0005488;nucleic acid binding#GO:0003676;translation factor activity#GO:0180051;RNA binding#GO:0003723;translation initiation factor activity#GO:0003743 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 eukaryotic translation initiation factor 3 complex#GO:0005852;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG184059|UniProtKB=T1FKI2 T1FKI2 20209331 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168358|UniProtKB=T1F0G7 T1F0G7 20202317 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG184573|UniProtKB=T1FLI2 T1FLI2 20209681 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172502|UniProtKB=T1F5F1 T1F5F1 20204050 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG82368|UniProtKB=T1G4R3 T1G4R3 20216061 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194757|UniProtKB=T1FWD5 T1FWD5 20213130 PTHR12479:SF10 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of membrane permeability#GO:0090559 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765 transporter#PC00227 HELRO|EnsemblGenome=HelroG162491|UniProtKB=T1ESQ9 T1ESQ9 20199609 PTHR13473:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L48 LARGE RIBOSOMAL SUBUNIT PROTEIN ML48 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;metabolic process#GO:0008152;translation#GO:0006412;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG168092|UniProtKB=T1F057 T1F057 20202207 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836 metal ion transport#GO:0030001;action potential#GO:0001508;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG73759|UniProtKB=T1G1I1 T1G1I1 20214929 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976 neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;embryo development#GO:0009790;positive regulation of macromolecule metabolic process#GO:0010604;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryonic organ development#GO:0048568;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG165541|UniProtKB=T1EWZ7 T1EWZ7 20201097 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG179923|UniProtKB=T1FF92 T1FF92 20207491 PTHR21568:SF0 TRNA PSEUDOURIDINE SYNTHASE PUS10 TRNA PSEUDOURIDINE SYNTHASE PUS10 isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;tRNA modification#GO:0006400;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;tRNA processing#GO:0008033;primary miRNA processing#GO:0031053;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;macromolecule modification#GO:0043412;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG174976|UniProtKB=T1F8N9 T1F8N9 20205188 PTHR22805:SF2 WDR41-RELATED WD REPEAT-CONTAINING PROTEIN 41 HELRO|EnsemblGenome=HelroG193892|UniProtKB=T1FVG3 T1FVG3 20212809 PTHR15954:SF4 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG Golgi organization#GO:0007030;cellular component organization#GO:0016043;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;retrograde transport, endosome to Golgi#GO:0042147;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG103742|UniProtKB=T1EDH2 T1EDH2 20194624 PTHR10799:SF964 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD_H BOX 1 catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682 positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;DNA double-strand break processing#GO:0000729;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;heterochromatin formation#GO:0031507;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;double-strand break repair#GO:0006302;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to stress#GO:0033554;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG90218|UniProtKB=T1G7M4 T1G7M4 20217071 PTHR23050:SF558 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 6 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG116278|UniProtKB=T1EGD9 T1EGD9 20195641 PTHR31993:SF4 UBA-LIKE DOMAIN-CONTAINING PROTEIN 2 UBA-LIKE DOMAIN-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG157123|UniProtKB=T1EM65 T1EM65 20197665 PTHR10454:SF210 CASPASE CASPASE FAMILY P20 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;programmed cell death#GO:0012501;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;regulation of apoptotic process#GO:0042981;positive regulation of neuron apoptotic process#GO:0043525;positive regulation of apoptotic process#GO:0043065 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG184320|UniProtKB=T1FKZ6 T1FKZ6 20209495 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167069|UniProtKB=T1EYZ0 T1EYZ0 20201790 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG189111|UniProtKB=T1FQN9 T1FQN9 20211136 PTHR24034:SF111 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE64043P cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG185734|UniProtKB=T1FN78 T1FN78 20210276 PTHR11067:SF9 INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN INOSINE TRIPHOSPHATE PYROPHOSPHATASE nucleoside triphosphate diphosphatase activity#GO:0047429;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG166864|UniProtKB=T1EYN5 T1EYN5 20201685 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182973|UniProtKB=T1FJ08 T1FJ08 20208807 PTHR13297:SF5 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HELRO|EnsemblGenome=HelroG161095|UniProtKB=T1ER36 T1ER36 20199036 PTHR14796:SF3 NEURENSIN 1-RELATED NEURENSIN 1-LIKE-RELATED developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;nervous system development#GO:0007399;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501 neuron projection#GO:0043005;transport vesicle#GO:0030133;endomembrane system#GO:0012505;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;cell body#GO:0044297;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG110729|UniProtKB=T1EF46 T1EF46 20195198 PTHR45918:SF1 ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2 ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG98827|UniProtKB=T1G9Q0 T1G9Q0 20217796 PTHR10540:SF7 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368 translation initiation factor#PC00224 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG100946|UniProtKB=T1ED23 T1ED23 20194475 PTHR11777:SF9 ALANYL-TRNA SYNTHETASE ALANINE--TRNA LIGASE, CYTOPLASMIC carboxylic ester hydrolase activity#GO:0052689;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;ligase activity#GO:0016874;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;deacylase activity#GO:0160215;catalytic activity, acting on RNA#GO:0140098 protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG63303|UniProtKB=T1FXD8 T1FXD8 20213486 PTHR24356:SF449 SERINE/THREONINE-PROTEIN KINASE 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to chemical stimulus#GO:0070887;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to oxygen-containing compound#GO:1901700;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to peptide hormone stimulus#GO:0071375;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>PDK1/2#P04616;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PDK1#P00831;PI3 kinase pathway#P00048>P110ACT#P01177;Ras Pathway#P04393>PDK#P04555;Interleukin signaling pathway#P00036>PDK1/2#P00985;PI3 kinase pathway#P00048>PDK1#P01196;CCKR signaling map#P06959>PDPK1#P07162;PI3 kinase pathway#P00048>PDK1 ACT#P01190;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PDK1/2#P00903;PDGF signaling pathway#P00047>PDK1/2#P01164;p53 pathway feedback loops 2#P04398>PDK1/2#P04656 HELRO|EnsemblGenome=HelroG192979|UniProtKB=T1FUH3 T1FUH3 20212469 PTHR13142:SF1 INNER CENTROMERE PROTEIN INNER CENTROMERE PROTEIN protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;spindle#GO:0005819;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;midbody#GO:0030496;kinetochore#GO:0000776;chromosomal region#GO:0098687;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG185298|UniProtKB=T1FMM6 T1FMM6 20210075 PTHR20426:SF0 RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG 18S RRNA AMINOCARBOXYPROPYLTRANSFERASE catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG184893|UniProtKB=T1FM49 T1FM49 20209898 PTHR12736:SF21 LANC-LIKE PROTEIN LANC-LIKE PROTEIN 2 regulation of response to alcohol#GO:1901419;regulation of signaling#GO:0023051;regulation of abscisic acid-activated signaling pathway#GO:0009787;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cellular response to alcohol#GO:1905957;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG163642|UniProtKB=T1EUA9 T1EUA9 20200159 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184512|UniProtKB=T1FLD1 T1FLD1 20209630 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77491|UniProtKB=T1G2Y5 T1G2Y5 20215433 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162346|UniProtKB=T1ESJ2 T1ESJ2 20199542 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG188603|UniProtKB=T1FQ61 T1FQ61 20210958 PTHR13440:SF7 BLOC-1 RELATED COMPLEX SUBUNIT 6 BLOC-1 RELATED COMPLEX SUBUNIT 6 localization#GO:0051179;lysosome localization#GO:0032418;organelle localization#GO:0051640 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG160110|UniProtKB=T1EPT3 T1EPT3 20198583 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109117|UniProtKB=T1EEQ5 T1EEQ5 20195057 PTHR45679:SF2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 catabolic process#GO:0009056;regulation of cellular process#GO:0050794;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of biological process#GO:0050789;response to unfolded protein#GO:0006986;response to oxygen-containing compound#GO:1901700;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycoprotein metabolic process#GO:0009100 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG94766|UniProtKB=T1G930 T1G930 20217577 PTHR11140:SF0 PRE-MRNA SPLICING FACTOR PRP8 PRE-MRNA-PROCESSING-SPLICING FACTOR 8 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG100479|UniProtKB=T1ECZ9 T1ECZ9 20194451 PTHR11102:SF147 SEL-1-LIKE PROTEIN PROTEIN SEL-1 HOMOLOG 1 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG171205|UniProtKB=T1F3X8 T1F3X8 20203527 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG90362|UniProtKB=T1G7P8 T1G7P8 20217095 PTHR10934:SF2 60S RIBOSOMAL PROTEIN L18 LARGE RIBOSOMAL SUBUNIT PROTEIN EL18 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG166150|UniProtKB=T1EXU4 T1EXU4 20201394 PTHR10663:SF342 GUANYL-NUCLEOTIDE EXCHANGE FACTOR FI21420P1 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of biological quality#GO:0065008;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG190236|UniProtKB=T1FRT1 T1FRT1 20211528 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG150360|UniProtKB=T1EKF2 T1EKF2 20197052 PTHR22957:SF601 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 30 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185695|UniProtKB=T1FN58 T1FN58 20210256 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG166823|UniProtKB=T1EYK7 T1EYK7 20201657 PTHR22677:SF4 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60 REPEAT PROTEIN, PUTATIVE-RELATED HELRO|EnsemblGenome=HelroG166651|UniProtKB=T1EYB8 T1EYB8 20201568 PTHR24104:SF47 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED THIN, ISOFORM C ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG179717|UniProtKB=T1FF25 T1FF25 20207424 PTHR23196:SF42 PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN PAX-INTERACTING PROTEIN 1 response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG189162|UniProtKB=T1FQQ5 T1FQQ5 20211152 PTHR12345:SF16 SYNTENIN RELATED X11L, ISOFORM F-RELATED anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of biological process#GO:0050789;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537 cell junction#GO:0030054;cytoplasm#GO:0005737;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;dendritic tree#GO:0097447;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cell projection#GO:0042995;postsynapse#GO:0098794;dendritic spine#GO:0043197 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG104410|UniProtKB=T1EDL5 T1EDL5 20194667 PTHR47958:SF31 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG178526|UniProtKB=T1FDB2 T1FDB2 20206811 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74132|UniProtKB=T1G1M5 T1G1M5 20214973 PTHR20931:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 30 TETRATRICOPEPTIDE REPEAT PROTEIN 30 protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;intraciliary transport#GO:0042073;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;cilium organization#GO:0044782;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;intracellular transport#GO:0046907;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule#GO:0005874;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG86324|UniProtKB=T1G6A4 T1G6A4 20216601 PTHR10755:SF0 COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;tetrapyrrole biosynthetic process#GO:0033014;cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;porphyrin-containing compound biosynthetic process#GO:0006779;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;oxidase#PC00175;oxidoreductase#PC00176 Heme biosynthesis#P02746>Coproporphyrinogen Oxidase (oxygen dependent)#P02980 HELRO|EnsemblGenome=HelroG185740|UniProtKB=T1FN80 T1FN80 20210278 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG186765|UniProtKB=T1FP32 T1FP32 20210579 PTHR12058:SF0 ARP2/3 COMPLEX 34 KDA SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;supramolecular fiber organization#GO:0097435;cortical actin cytoskeleton organization#GO:0030866;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;actin filament polymerization#GO:0030041;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;actin cytoskeleton#GO:0015629;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Integrin signalling pathway#P00034>Arp2/3#P00912 HELRO|EnsemblGenome=HelroG80277|UniProtKB=T1G3Z3 T1G3Z3 20215791 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185743|UniProtKB=T1FN82 T1FN82 20210280 PTHR12290:SF48 CORNICHON-RELATED PROTEIN CORNICHON transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191267|UniProtKB=T1FST5 T1FST5 20211882 PTHR43078:SF54 UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED UDP-GLUCURONIC ACID DECARBOXYLASE 1 lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;organophosphate biosynthetic process#GO:0090407 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 lyase#PC00144;decarboxylase#PC00089 HELRO|EnsemblGenome=HelroG140157|UniProtKB=T1EJ01 T1EJ01 20196551 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG175703|UniProtKB=T1F9J6 T1F9J6 20205495 PTHR48068:SF4 TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;SAGA-type complex#GO:0070461;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;peptidase complex#GO:1905368;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;acetyltransferase complex#GO:1902493;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;SAGA complex#GO:0000124;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HELRO|EnsemblGenome=HelroG79631|UniProtKB=T1G3R6 T1G3R6 20215714 PTHR10778:SF8 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG163822|UniProtKB=T1EUI4 T1EUI4 20200234 PTHR11567:SF213 ACID PHOSPHATASE-RELATED 2-PHOSPHOXYLOSE PHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;chondroitin sulfate proteoglycan metabolic process#GO:0050654;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG191068|UniProtKB=T1FSK1 T1FSK1 20211798 PTHR17357:SF0 GM2 GANGLIOSIDE ACTIVATOR PROTEIN GANGLIOSIDE GM2 ACTIVATOR molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 lipid localization#GO:0010876;localization#GO:0051179;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;carbohydrate derivative catabolic process#GO:1901136;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;transport#GO:0006810;lipid metabolic process#GO:0006629;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;carbohydrate derivative metabolic process#GO:1901135;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid transport#GO:0006869 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG185702|UniProtKB=T1FN60 T1FN60 20210258 PTHR24071:SF0 RAN GTPASE GTP-BINDING NUCLEAR PROTEIN RAN hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 gene expression#GO:0010467;protein export from nucleus#GO:0006611;cellular component biogenesis#GO:0044085;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit export from nucleus#GO:0000055;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;protein transport#GO:0015031;protein import into nucleus#GO:0006606;ribosome biogenesis#GO:0042254;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;ribosomal subunit export from nucleus#GO:0000054;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;localization#GO:0051179;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;organelle localization#GO:0051640;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG188630|UniProtKB=T1FQ71 T1FQ71 20210968 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG169042|UniProtKB=T1F1A9 T1F1A9 20202609 PTHR11304:SF29 EPHRIN EPHRIN binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 intercellular signal molecule#PC00207;membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG169842|UniProtKB=T1F2D3 T1F2D3 20202983 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG159559|UniProtKB=T1EP59 T1EP59 20198359 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG190437|UniProtKB=T1FRZ7 T1FRZ7 20211594 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG98248|UniProtKB=T1G9L2 T1G9L2 20217758 PTHR11202:SF38 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED actin polymerization or depolymerization#GO:0008154;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;actin filament organization#GO:0007015;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;filopodium#GO:0030175;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cell projection#GO:0042995 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG150062|UniProtKB=T1EKE2 T1EKE2 20197042 PTHR15362:SF7 PHOSPHATIDYLINOSITOL SYNTHASE PHOSPHATIDYLSERINE SYNTHASE 2 transferase#PC00220 HELRO|EnsemblGenome=HelroG74987|UniProtKB=T1G1Z1 T1G1Z1 20215089 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192276|UniProtKB=T1FTS4 T1FTS4 20212221 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transmembrane transport#GO:1902476;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG69374|UniProtKB=T1FZU2 T1FZU2 20214340 PTHR10605:SF65 HEPARAN SULFATE SULFOTRANSFERASE GH20068P transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160756|UniProtKB=T1EQP2 T1EQP2 20198892 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG189731|UniProtKB=T1FRB1 T1FRB1 20211358 PTHR23320:SF167 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG102788|UniProtKB=T1EDB9 T1EDB9 20194571 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN 84-LIKE transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG194973|UniProtKB=T1FWM1 T1FWM1 20213216 PTHR15463:SF2 AP1 GAMMA SUBUNIT BINDING PROTEIN 1 SYNERGIN GAMMA intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;trans-Golgi network transport vesicle#GO:0030140;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;coated membrane#GO:0048475;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737;clathrin-coated vesicle membrane#GO:0030665;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125 HELRO|EnsemblGenome=HelroG192732|UniProtKB=T1FU86 T1FU86 20212382 PTHR12385:SF12 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG170197|UniProtKB=T1F2S0 T1F2S0 20203119 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG80861|UniProtKB=T1G464 T1G464 20215862 PTHR14187:SF39 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12B HELRO|EnsemblGenome=HelroG170661|UniProtKB=T1F3A8 T1F3A8 20203307 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD CASPASE DRONC positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG186335|UniProtKB=T1FNY7 T1FNY7 20210534 PTHR18919:SF175 ACETYL-COA C-ACYLTRANSFERASE 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740 oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;lipid modification#GO:0030258;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG109192|UniProtKB=T1EER2 T1EER2 20195064 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG82982|UniProtKB=T1G4Y9 T1G4Y9 20216137 PTHR24115:SF1043 KINESIN-RELATED KINESIN-LIKE PROTEIN hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG191919|UniProtKB=T1FTF0 T1FTF0 20212097 PTHR33562:SF27 ATILLA, ISOFORM B-RELATED-RELATED FI02817P-RELATED HELRO|EnsemblGenome=HelroG121368|UniProtKB=T1EGR6 T1EGR6 20195766 PTHR24248:SF212 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HELRO|EnsemblGenome=HelroG190307|UniProtKB=T1FRW0 T1FRW0 20211557 PTHR22605:SF26 RZ-TYPE DOMAIN-CONTAINING PROTEIN RZ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174010|UniProtKB=T1F7H1 T1F7H1 20204770 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG70386|UniProtKB=T1G060 T1G060 20214458 PTHR12619:SF5 RFX TRANSCRIPTION FACTOR FAMILY RFX, ISOFORM H cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG159671|UniProtKB=T1EPA7 T1EPA7 20198407 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;tissue development#GO:0009888;multicellular organismal process#GO:0032501;cellular process#GO:0009987;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 basement membrane#GO:0005604;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG92371|UniProtKB=T1G8F2 T1G8F2 20217349 PTHR24185:SF10 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;olefinic compound metabolic process#GO:0120254;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;monocarboxylic acid metabolic process#GO:0032787;long-chain fatty acid metabolic process#GO:0001676;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;arachidonate metabolic process#GO:0019369;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690 membrane#GO:0016020;cellular anatomical structure#GO:0110165 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG68680|UniProtKB=T1FZI2 T1FZI2 20214230 PTHR45622:SF56 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 UBIQUITIN-PROTEIN LIGASE HECTD2-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG77530|UniProtKB=T1G2Z3 T1G2Z3 20215441 PTHR45881:SF7 CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED HELRO|EnsemblGenome=HelroG156918|UniProtKB=T1EM32 T1EM32 20197632 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG88976|UniProtKB=T1G778 T1G778 20216925 PTHR23276:SF2 PROTEIN PRRC1 PROTEIN PRRC1 protein kinase A regulatory subunit binding#GO:0034237;binding#GO:0005488;protein kinase A binding#GO:0051018;protein binding#GO:0005515 multicellular organismal-level homeostasis#GO:0048871;homeostatic process#GO:0042592;tissue homeostasis#GO:0001894;epithelial structure maintenance#GO:0010669;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG64249|UniProtKB=T1FXR7 T1FXR7 20213615 PTHR12381:SF56 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG193770|UniProtKB=T1FVC3 T1FVC3 20212769 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG96758|UniProtKB=T1G9D6 T1G9D6 20217683 PTHR19876:SF2 COATOMER COATOMER SUBUNIT BETA' retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;COPI-coated vesicle#GO:0030137;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vesicle coat#GO:0030120;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG189171|UniProtKB=T1FQR0 T1FQR0 20211157 PTHR10336:SF149 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;transport#GO:0006810;establishment of localization#GO:0051234;organophosphate metabolic process#GO:0019637;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;G protein-coupled receptor signaling pathway#GO:0007186;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262;phospholipase#PC00186 Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Endothelin signaling pathway#P00019>PLCbeta#P00591;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Wnt signaling pathway#P00057>Phospholipase C#P01443;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HELRO|EnsemblGenome=HelroG167067|UniProtKB=T1EYY9 T1EYY9 20201789 PTHR48125:SF16 LP07818P1 UBZ4-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122380|UniProtKB=T1EGU6 T1EGU6 20195796 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG192162|UniProtKB=T1FTN1 T1FTN1 20212178 PTHR31901:SF9 GH3 DOMAIN-CONTAINING PROTEIN GH3 DOMAIN-CONTAINING PROTEIN ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG66807|UniProtKB=T1FYR1 T1FYR1 20213959 PTHR11830:SF3 40S RIBOSOMAL PROTEIN S3A UBIQUITINYL HYDROLASE 1 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;structural constituent of ribosome#GO:0003735;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;structural molecule activity#GO:0005198;peptidase activity#GO:0008233 translation#GO:0006412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG78629|UniProtKB=T1G3D8 T1G3D8 20215586 PTHR43595:SF2 37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS42 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162396|UniProtKB=T1ESL7 T1ESL7 20199567 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190872|UniProtKB=T1FSD5 T1FSD5 20211732 PTHR14002:SF65 ENDOGLIN/TGF-BETA RECEPTOR TYPE III TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG116471|UniProtKB=T1EGF2 T1EGF2 20195654 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG81550|UniProtKB=T1G4F7 T1G4F7 20215955 PTHR23506:SF45 GH10249P GH10249P symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;solute:sodium symporter activity#GO:0015370;chloride transmembrane transporter activity#GO:0015108;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804 nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;cellular localization#GO:0051641 vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;neuron projection terminus#GO:0044306;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;axon#GO:0030424;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;axon terminus#GO:0043679;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588 transporter#PC00227;secondary carrier transporter#PC00258 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424 HELRO|EnsemblGenome=HelroG63126|UniProtKB=T1FXB4 T1FXB4 20213462 PTHR11071:SF581 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG166093|UniProtKB=T1EXR1 T1EXR1 20201361 PTHR24023:SF1066 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG182562|UniProtKB=T1FIC7 T1FIC7 20208576 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG112383|UniProtKB=T1EFJ4 T1EFJ4 20195346 PTHR10953:SF29 UBIQUITIN-ACTIVATING ENZYME E1 NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;transferase activity, transferring sulphur-containing groups#GO:0016782 post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159741|UniProtKB=T1EPC9 T1EPC9 20198429 PTHR23423:SF21 ORGANIC SOLUTE TRANSPORTER-RELATED ORGANIC SOLUTE TRANSPORTER SUBUNIT ALPHA transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG167644|UniProtKB=T1EZL8 T1EZL8 20202018 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG189553|UniProtKB=T1FR52 T1FR52 20211299 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG85345|UniProtKB=T1G5V6 T1G5V6 20216453 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169388|UniProtKB=T1F1V8 T1F1V8 20202808 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG195049|UniProtKB=T1FWQ0 T1FWQ0 20213245 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG115787|UniProtKB=T1EGA5 T1EGA5 20195607 PTHR22957:SF645 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 15 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG156571|UniProtKB=T1ELY5 T1ELY5 20197585 PTHR24351:SF234 RIBOSOMAL PROTEIN S6 KINASE SERINE_THREONINE-PROTEIN KINASE YPK2_YKR2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164568|UniProtKB=T1EVK7 T1EVK7 20200607 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG160584|UniProtKB=T1EQG3 T1EQG3 20198813 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 binding#GO:0005488;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG150377|UniProtKB=T1EKF3 T1EKF3 20197053 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;cation binding#GO:0043169;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 cellular response to stress#GO:0033554;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;response to starvation#GO:0042594;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of carbohydrate biosynthetic process#GO:0043255;cellular response to starvation#GO:0009267;regulation of carbohydrate metabolic process#GO:0006109;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;response to nutrient levels#GO:0031667;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG88345|UniProtKB=T1G716 T1G716 20216863 PTHR46205:SF3 LOQUACIOUS, ISOFORM B PROTEIN LOQUACIOUS double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of gene expression#GO:0010468;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;siRNA processing#GO:0030422;regulation of biological process#GO:0050789;regulation of gene silencing by regulatory ncRNA#GO:0060966;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG113992|UniProtKB=T1EFX9 T1EFX9 20195481 PTHR24006:SF747 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG184519|UniProtKB=T1FLD8 T1FLD8 20209637 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157357|UniProtKB=T1EMA2 T1EMA2 20197702 PTHR10871:SF3 30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18 SMALL RIBOSOMAL SUBUNIT PROTEIN US13 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG191092|UniProtKB=T1FSL1 T1FSL1 20211808 PTHR11309:SF47 FRIZZLED FRIZZLED Wnt-protein binding#GO:0017147;molecular transducer activity#GO:0060089;protein binding#GO:0005515;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;non-canonical Wnt signaling pathway#GO:0035567;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Angiogenesis#P00005>Fzd#P00189;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG165232|UniProtKB=T1EWH1 T1EWH1 20200921 PTHR31735:SF1 VACUOLAR MEMBRANE PROTEIN YPL162C VACUOLAR MEMBRANE PROTEIN YPL162C membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG159365|UniProtKB=T1ENY0 T1ENY0 20198280 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG111285|UniProtKB=T1EFA1 T1EFA1 20195253 PTHR14859:SF1 CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR PGAP2-INTERACTING PROTEIN macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG119637|UniProtKB=T1EGN4 T1EGN4 20195734 PTHR22762:SF131 ALPHA-GLUCOSIDASE LYSOSOMAL ALPHA-GLUCOSIDASE-LIKE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599 glucosidase#PC00108 HELRO|EnsemblGenome=HelroG65192|UniProtKB=T1FY45 T1FY45 20213743 PTHR45777:SF2 METHIONINE AMINOPEPTIDASE 2 METHIONINE AMINOPEPTIDASE 2 exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188572|UniProtKB=T1FQ50 T1FQ50 20210947 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG194512|UniProtKB=T1FW50 T1FW50 20213046 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804 postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG163413|UniProtKB=T1EU07 T1EU07 20200057 PTHR12243:SF69 MADF DOMAIN TRANSCRIPTION FACTOR GH22016P-RELATED regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG160453|UniProtKB=T1EQ94 T1EQ94 20198744 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843 monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG166542|UniProtKB=T1EY81 T1EY81 20201531 PTHR11668:SF530 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Y-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG164367|UniProtKB=T1EVB7 T1EVB7 20200517 PTHR23048:SF0 MYOSIN LIGHT CHAIN 1, 3 FI08416P-RELATED actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG81101|UniProtKB=T1G491 T1G491 20215889 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG77249|UniProtKB=T1G2V0 T1G2V0 20215398 PTHR21178:SF8 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227 structural protein#PC00211 HELRO|EnsemblGenome=HelroG161481|UniProtKB=T1ERI9 T1ERI9 20199189 PTHR10454:SF252 CASPASE CASPASE-8 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 positive regulation of apoptotic process#GO:0043065;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;programmed cell death#GO:0012501;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;cellular process#GO:0009987;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG90075|UniProtKB=T1G7K8 T1G7K8 20217055 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824 nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;ribose phosphate biosynthetic process#GO:0046390;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG183207|UniProtKB=T1FJB2 T1FJB2 20208911 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG112809|UniProtKB=T1EFM3 T1EFM3 20195375 PTHR11785:SF531 AMINO ACID TRANSPORTER LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1 L-amino acid transmembrane transporter activity#GO:0015179;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171 localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG162405|UniProtKB=T1ESM0 T1ESM0 20199570 PTHR31964:SF113 ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN USPA DOMAIN-CONTAINING PROTEIN hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185670|UniProtKB=T1FN44 T1FN44 20210242 PTHR19965:SF35 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG143241|UniProtKB=T1EJ96 T1EJ96 20196646 PTHR13235:SF2 SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE catalytic activity, acting on DNA#GO:0140097;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA N-glycosylase activity#GO:0019104 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;base-excision repair#GO:0006284;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG182698|UniProtKB=T1FIL4 T1FIL4 20208663 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG112716|UniProtKB=T1EFL5 T1EFL5 20195367 PTHR14795:SF0 HELICASE RELATED TRANSMEMBRANE PROTEIN 62 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG116445|UniProtKB=T1EGF1 T1EGF1 20195653 PTHR21321:SF4 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP4 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound catabolic process#GO:0034655;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;snRNA 3'-end processing#GO:0034472;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187 intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG72098|UniProtKB=T1G0V6 T1G0V6 20214704 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 tetrapyrrole binding#GO:0046906;binding#GO:0005488;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG75117|UniProtKB=T1G211 T1G211 20215109 PTHR47980:SF101 LD44762P IP08727P-RELATED localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;secretion by cell#GO:0032940;localization within membrane#GO:0051668;endocytic recycling#GO:0032456;export from cell#GO:0140352;establishment of localization#GO:0051234;endosomal transport#GO:0016197;exocytosis#GO:0006887;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;trans-Golgi network transport vesicle#GO:0030140;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG184792|UniProtKB=T1FM02 T1FM02 20209851 PTHR48529:SF1 FAMILY NOT NAMED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG192152|UniProtKB=T1FTM9 T1FTM9 20212176 PTHR46169:SF15 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG167056|UniProtKB=T1EYY6 T1EYY6 20201786 PTHR31214:SF2 PROTEIN FAM221A-RELATED PROTEIN FAM221A HELRO|EnsemblGenome=HelroG110414|UniProtKB=T1EF20 T1EF20 20195172 PTHR24073:SF1240 DRAB5-RELATED RAS-RELATED PROTEIN RAB5 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;import into cell#GO:0098657;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;endocytosis#GO:0006897 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG75335|UniProtKB=T1G238 T1G238 20215136 PTHR23048:SF33 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN ALKALI actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;contractile muscle fiber#GO:0043292;supramolecular complex#GO:0099080;organelle#GO:0043226;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG119358|UniProtKB=T1EGM9 T1EGM9 20195729 PTHR15859:SF1 SETA BINDING PROTEIN 1 BTB DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG101454|UniProtKB=T1ED46 T1ED46 20194498 PTHR48109:SF4 DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;carbohydrate derivative metabolic process#GO:1901135;pyrimidine-containing compound metabolic process#GO:0072527;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;pyrimidine nucleobase metabolic process#GO:0006206;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Dihydrooratate oxidase#P02927 HELRO|EnsemblGenome=HelroG186285|UniProtKB=T1FNX1 T1FNX1 20210518 PTHR11977:SF130 VILLIN SEVERIN cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of actin filament depolymerization#GO:0030834;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG192309|UniProtKB=T1FTT4 T1FTT4 20212231 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG117017|UniProtKB=T1EGJ3 T1EGJ3 20195695 PTHR14958:SF29 POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN INSOMNIAC, ISOFORM B binding#GO:0005488;protein binding#GO:0005515 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156550|UniProtKB=T1ELY1 T1ELY1 20197581 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG193803|UniProtKB=T1FVD4 T1FVD4 20212780 PTHR46745:SF1 TSC22 DOMAIN FAMILY PROTEIN 1 TSC22 DOMAIN FAMILY PROTEIN 1 regulation of cell population proliferation#GO:0042127;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of cell population proliferation#GO:0008284 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG156908|UniProtKB=T1EM28 T1EM28 20197628 PTHR10920:SF12 RIBOSOMAL RNA METHYLTRANSFERASE TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG157030|UniProtKB=T1EM49 T1EM49 20197649 PTHR24286:SF397 CYTOCHROME P450 26 LANOSTEROL 14-ALPHA DEMETHYLASE catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG191272|UniProtKB=T1FST8 T1FST8 20211885 PTHR12085:SF8 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT RSA-1 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cortical cytoskeleton organization#GO:0030865 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG97497|UniProtKB=T1G9H4 T1G9H4 20217721 PTHR10953:SF4 UBIQUITIN-ACTIVATING ENZYME E1 E1 UBIQUITIN-ACTIVATING ENZYME ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;ligase activity#GO:0016874;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a protein#GO:0140096 catabolic process#GO:0009056;response to stimulus#GO:0050896;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG78193|UniProtKB=T1G392 T1G392 20215540 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG181329|UniProtKB=T1FGW4 T1FGW4 20208063 PTHR19960:SF25 TEKTIN TEKTIN-1 cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG72350|UniProtKB=T1G0Y8 T1G0Y8 20214736 PTHR45973:SF8 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG185866|UniProtKB=T1FND5 T1FND5 20210332 PTHR11910:SF1 ATP SYNTHASE DELTA CHAIN ATP SYNTHASE PERIPHERAL STALK SUBUNIT OSCP, MITOCHONDRIAL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;proton channel activity#GO:0015252;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;aerobic respiration#GO:0009060;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine-containing compound metabolic process#GO:0072521;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP biosynthetic process#GO:0006754;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 primary active transporter#PC00068;transporter#PC00227;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG159579|UniProtKB=T1EP67 T1EP67 20198367 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG112743|UniProtKB=T1EFL8 T1EFL8 20195370 PTHR46223:SF3 HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG74366|UniProtKB=T1G1Q1 T1G1Q1 20214999 PTHR22762:SF54 ALPHA-GLUCOSIDASE GLUCOSIDASE II SUBUNIT ALPHA hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 biosynthetic process#GO:0009058;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 glucosidase#PC00108 HELRO|EnsemblGenome=HelroG156363|UniProtKB=T1ELU3 T1ELU3 20197543 PTHR13568:SF6 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 185B HELRO|EnsemblGenome=HelroG89616|UniProtKB=T1G7F0 T1G7F0 20216997 PTHR10920:SF18 RIBOSOMAL RNA METHYLTRANSFERASE RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL O-methyltransferase activity#GO:0008171;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;ribosomal large subunit assembly#GO:0000027;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;rRNA modification#GO:0000154;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;methylation#GO:0032259;RNA metabolic process#GO:0016070;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;rRNA methylation#GO:0031167;protein-containing complex organization#GO:0043933 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG185865|UniProtKB=T1FND4 T1FND4 20210331 PTHR11851:SF226 METALLOPROTEASE CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;cytochrome complex#GO:0070069;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endopeptidase complex#GO:1905369;respiratory chain complex III#GO:0045275;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;peptidase complex#GO:1905368;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG116430|UniProtKB=T1EGF0 T1EGF0 20195652 PTHR22762:SF131 ALPHA-GLUCOSIDASE LYSOSOMAL ALPHA-GLUCOSIDASE-LIKE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;alpha-glucosidase activity#GO:0090599;glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 glucosidase#PC00108 HELRO|EnsemblGenome=HelroG191235|UniProtKB=T1FSR9 T1FSR9 20211866 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG98395|UniProtKB=T1G9M3 T1G9M3 20217769 PTHR20856:SF8 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098 nucleic acid biosynthetic process#GO:0141187;snRNA transcription by RNA polymerase III#GO:0042796;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;snRNA transcription#GO:0009301;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190717|UniProtKB=T1FS83 T1FS83 20211680 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG84094|UniProtKB=T1G5E6 T1G5E6 20216293 PTHR10381:SF11 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL hydrolase activity#GO:0016787;protein binding#GO:0005515;serine hydrolase activity#GO:0017171;binding#GO:0005488;serine-type peptidase activity#GO:0008236;enzyme binding#GO:0019899;ATP-dependent activity#GO:0140657;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515 protein-containing complex#GO:0032991;catalytic complex#GO:1902494 serine protease#PC00203 HELRO|EnsemblGenome=HelroG187100|UniProtKB=T1FP70 T1FP70 20210617 PTHR24353:SF111 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;receptor guanylyl cyclase signaling pathway#GO:0007168;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor signaling pathway#GO:0007166 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Endothelin signaling pathway#P00019>PKG#P00567 HELRO|EnsemblGenome=HelroG186712|UniProtKB=T1FP24 T1FP24 20210571 PTHR14269:SF4 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CAT EYE SYNDROME CRITICAL REGION PROTEIN 5 lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193374|UniProtKB=T1FUX5 T1FUX5 20212621 PTHR23354:SF132 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED OXIDATION RESISTANCE PROTEIN 1 response to stimulus#GO:0050896;response to oxidative stress#GO:0006979;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG175491|UniProtKB=T1F9B7 T1F9B7 20205416 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG76918|UniProtKB=T1G2R3 T1G2R3 20215361 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92749|UniProtKB=T1G8K4 T1G8K4 20217401 PTHR13832:SF803 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE CG10417-RELATED phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG116079|UniProtKB=T1EGC8 T1EGC8 20195630 PTHR13832:SF883 PROTEIN PHOSPHATASE 2C INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG183636|UniProtKB=T1FJZ0 T1FJZ0 20209139 PTHR16021:SF26 MANSC DOMAIN CONTAINING PROTEIN 1 PEPTIDASE M43 PREGNANCY-ASSOCIATED PLASMA-A DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193474|UniProtKB=T1FV14 T1FV14 20212660 PTHR13946:SF28 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HELRO|EnsemblGenome=HelroG173674|UniProtKB=T1F739 T1F739 20204638 PTHR47020:SF1 HILLARIN HILLARIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175287|UniProtKB=T1F941 T1F941 20205340 PTHR46513:SF41 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>LRP5/6#P01431 HELRO|EnsemblGenome=HelroG178803|UniProtKB=T1FDR5 T1FDR5 20206964 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189644|UniProtKB=T1FR82 T1FR82 20211329 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG65295|UniProtKB=T1FY56 T1FY56 20213754 PTHR11909:SF300 CASEIN KINASE-RELATED TAU-TUBULIN KINASE HOMOLOG ASATOR protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG115456|UniProtKB=T1EG83 T1EG83 20195585 PTHR45876:SF8 FI04035P RHO GTPASE-ACTIVATING PROTEIN 39 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG175481|UniProtKB=T1F9A9 T1F9A9 20205408 PTHR14592:SF15 UNCHARACTERIZED FAM3 ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG172419|UniProtKB=T1F5A9 T1F5A9 20204008 PTHR24320:SF294 RETINOL DEHYDROGENASE NADP-RETINOL DEHYDROGENASE-RELATED catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG85277|UniProtKB=T1G5V0 T1G5V0 20216447 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG67579|UniProtKB=T1FZ25 T1FZ25 20214073 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG63471|UniProtKB=T1FXG3 T1FXG3 20213511 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG181060|UniProtKB=T1FGK4 T1FGK4 20207953 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180060|UniProtKB=T1FFF2 T1FFF2 20207551 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166478|UniProtKB=T1EY62 T1EY62 20201512 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrion organization#GO:0007005;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG186287|UniProtKB=T1FNX3 T1FNX3 20210520 PTHR46009:SF1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;establishment of localization in cell#GO:0051649;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;late endosome#GO:0005770;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG190504|UniProtKB=T1FS19 T1FS19 20211616 PTHR24412:SF497 KELCH PROTEIN KELCH-LIKE PROTEIN 18 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194138|UniProtKB=T1FVQ9 T1FVQ9 20212905 PTHR10829:SF59 CORTACTIN AND DREBRIN COACTOSIN actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840 cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;actin filament#GO:0005884;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG164377|UniProtKB=T1EVC5 T1EVC5 20200525 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;trans-Golgi network membrane#GO:0032588;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG158422|UniProtKB=T1EMR9 T1EMR9 20197869 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG68275|UniProtKB=T1FZC5 T1FZC5 20214173 PTHR19134:SF561 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN SDF-9-RELATED protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG90411|UniProtKB=T1G7R1 T1G7R1 20217108 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG189946|UniProtKB=T1FRI7 T1FRI7 20211434 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG73469|UniProtKB=T1G1E1 T1G1E1 20214889 PTHR10966:SF0 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 protein binding#GO:0005515;binding#GO:0005488;transcription factor binding#GO:0008134 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933 nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG179895|UniProtKB=T1FF85 T1FF85 20207484 PTHR31004:SF1 TRANSMEMBRANE PROTEIN 79 TRANSMEMBRANE PROTEIN 79 regulated exocytosis#GO:0045055;transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352 intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;lysosomal membrane#GO:0005765;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;vacuole#GO:0005773;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG63547|UniProtKB=T1FXH2 T1FXH2 20213520 PTHR15852:SF54 PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN PROTEIN SSUH2 HOMOLOG HELRO|EnsemblGenome=HelroG180165|UniProtKB=T1FFJ2 T1FFJ2 20207591 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG99384|UniProtKB=T1G9S4 T1G9S4 20217820 PTHR15422:SF45 OS05G0565100 PROTEIN ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE) HELRO|EnsemblGenome=HelroG113493|UniProtKB=T1EFS9 T1EFS9 20195431 PTHR10067:SF6 PHOSPHATIDYLSERINE DECARBOXYLASE PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;lyase activity#GO:0016829 glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 lyase#PC00144;metabolite interconversion enzyme#PC00262;decarboxylase#PC00089 HELRO|EnsemblGenome=HelroG79842|UniProtKB=T1G3U2 T1G3U2 20215740 PTHR24320:SF294 RETINOL DEHYDROGENASE NADP-RETINOL DEHYDROGENASE-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG72282|UniProtKB=T1G0Y0 T1G0Y0 20214728 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG77273|UniProtKB=T1G2V5 T1G2V5 20215403 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE peptide receptor activity#GO:0001653;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG93565|UniProtKB=T1G8W6 T1G8W6 20217513 PTHR11846:SF0 ADENYLOSUCCINATE SYNTHETASE ADENYLOSUCCINATE SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;De novo purine biosynthesis#P02738>Adenylosuccinate synthase#P02890 HELRO|EnsemblGenome=HelroG190275|UniProtKB=T1FRU8 T1FRU8 20211545 PTHR23148:SF0 SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG166608|UniProtKB=T1EYA5 T1EYA5 20201555 PTHR10166:SF37 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED STOLID, ISOFORM H channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;calcium channel complex#GO:0034704;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG190105|UniProtKB=T1FRP5 T1FRP5 20211492 PTHR43785:SF12 GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE TYPE-1 GLUTAMINE SYNTHETASE 2 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG166590|UniProtKB=T1EYA1 T1EYA1 20201551 PTHR11949:SF17 INTERFERON REGULATORY FACTOR IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG87875|UniProtKB=T1G6W3 T1G6W3 20216810 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 protein binding#GO:0005515;binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;transport#GO:0006810 cell junction#GO:0030054;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;presynapse#GO:0098793;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708 HELRO|EnsemblGenome=HelroG180358|UniProtKB=T1FFT6 T1FFT6 20207685 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG183403|UniProtKB=T1FJK8 T1FJK8 20209007 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG180066|UniProtKB=T1FFF7 T1FFF7 20207556 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81324|UniProtKB=T1G4D0 T1G4D0 20215928 PTHR23506:SF45 GH10249P GH10249P transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;solute:sodium symporter activity#GO:0015370 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;cellular localization#GO:0051641;localization#GO:0051179 organelle membrane#GO:0031090;axon terminus#GO:0043679;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;axon#GO:0030424;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;neuron projection terminus#GO:0044306;terminal bouton#GO:0043195;intracellular membrane-bounded organelle#GO:0043231;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular vesicle#GO:0097708;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995 transporter#PC00227;secondary carrier transporter#PC00258 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424 HELRO|EnsemblGenome=HelroG87629|UniProtKB=T1G6T3 T1G6T3 20216780 PTHR23506:SF45 GH10249P GH10249P monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;solute:sodium symporter activity#GO:0015370;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;localization#GO:0051179;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;cellular localization#GO:0051641 neuron projection terminus#GO:0044306;intracellular membrane-bounded organelle#GO:0043231;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;vesicle membrane#GO:0012506;membrane#GO:0016020;axon terminus#GO:0043679;organelle membrane#GO:0031090;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular vesicle#GO:0097708;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588 transporter#PC00227;secondary carrier transporter#PC00258 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424 HELRO|EnsemblGenome=HelroG170771|UniProtKB=T1F3E7 T1F3E7 20203346 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG159628|UniProtKB=T1EP94 T1EP94 20198394 PTHR12064:SF97 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM-5 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183668|UniProtKB=T1FK06 T1FK06 20209155 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG82945|UniProtKB=T1G4Y3 T1G4Y3 20216131 PTHR47977:SF128 RAS-RELATED PROTEIN RAB LD21953P hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456;transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;plasma membrane#GO:0005886;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG74833|UniProtKB=T1G1W2 T1G1W2 20215060 PTHR14592:SF15 UNCHARACTERIZED FAM3 ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG159718|UniProtKB=T1EPC4 T1EPC4 20198424 PTHR11711:SF41 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1 heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001 cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf1#P00923 HELRO|EnsemblGenome=HelroG63383|UniProtKB=T1FXF1 T1FXF1 20213499 PTHR13624:SF6 RE42071P EMEI HELRO|EnsemblGenome=HelroG162799|UniProtKB=T1ET62 T1ET62 20199762 PTHR12509:SF9 SPERMATOGENESIS-ASSOCIATED 4-RELATED SPERM FLAGELLAR PROTEIN 1 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG176792|UniProtKB=T1FAX1 T1FAX1 20205970 PTHR22545:SF0 CENTROSOMAL PROTEIN OF 95 KDA CENTROSOMAL PROTEIN OF 95 KDA intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922 HELRO|EnsemblGenome=HelroG69490|UniProtKB=T1FZV9 T1FZV9 20214357 PTHR24169:SF28 NUCLEAR FACTOR NF-KAPPA-B PROTEIN DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;intracellular signaling cassette#GO:0141124;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;canonical NF-kappaB signal transduction#GO:0007249;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 Rel homology transcription factor#PC00252;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Toll pathway-drosophila#P06217>DL#P06344;Toll receptor signaling pathway#P00054>NFkappaB#P01354 HELRO|EnsemblGenome=HelroG166882|UniProtKB=T1EYP7 T1EYP7 20201697 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70715|UniProtKB=T1G0B1 T1G0B1 20214509 PTHR43963:SF4 CARBONYL REDUCTASE 1-RELATED CARBONYL REDUCTASE (NADPH) catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164063|UniProtKB=T1EUV0 T1EUV0 20200350 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG157055|UniProtKB=T1EM56 T1EM56 20197656 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG167911|UniProtKB=T1EZY0 T1EZY0 20202130 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG151477|UniProtKB=T1EKK6 T1EKK6 20197106 PTHR15698:SF4 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG94029|UniProtKB=T1G8Y6 T1G8Y6 20217533 PTHR48102:SF7 ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED ATP-DEPENDENT CLPX-LIKE CHAPERONE, MITOCHONDRIAL ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190 HELRO|EnsemblGenome=HelroG179020|UniProtKB=T1FE25 T1FE25 20207074 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG109424|UniProtKB=T1EET7 T1EET7 20195089 PTHR43243:SF105 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HELRO|EnsemblGenome=HelroG66135|UniProtKB=T1FYH3 T1FYH3 20213871 PTHR11636:SF70 POU DOMAIN INHIBITORY POU PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG161814|UniProtKB=T1ERY0 T1ERY0 20199330 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG152036|UniProtKB=T1EKN7 T1EKN7 20197137 PTHR24333:SF17 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX PROTEIN UNPLUGGED-RELATED homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG89856|UniProtKB=T1G7I4 T1G7I4 20217031 PTHR10414:SF78 ETHANOLAMINEPHOSPHOTRANSFERASE DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE transferase#PC00220 HELRO|EnsemblGenome=HelroG156279|UniProtKB=T1ELT7 T1ELT7 20197537 PTHR24023:SF1140 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG162197|UniProtKB=T1ESC4 T1ESC4 20199474 PTHR12825:SF0 BNIP1-RELATED VESICLE TRANSPORT PROTEIN SEC20 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;endomembrane system#GO:0012505;membrane protein complex#GO:0098796;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG185153|UniProtKB=T1FMG3 T1FMG3 20210012 PTHR22811:SF210 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN P24-RELATED-1, ISOFORM A cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;macromolecule localization#GO:0033036 endomembrane system#GO:0012505;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG156394|UniProtKB=T1ELV4 T1ELV4 20197554 PTHR45668:SF5 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 5 hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG195131|UniProtKB=T1FWS4 T1FWS4 20213269 PTHR19282:SF417 TETRASPANIN TOBAMOVIRUS MULTIPLICATION PROTEIN 2A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG97603|UniProtKB=T1G9I0 T1G9I0 20217727 PTHR24012:SF918 RNA BINDING PROTEIN RRM DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143 biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG82913|UniProtKB=T1G4Y1 T1G4Y1 20216129 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG97089|UniProtKB=T1G9F3 T1G9F3 20217700 PTHR48101:SF4 METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED METHYLMALONYL-COA MUTASE, MITOCHONDRIAL intramolecular transferase activity#GO:0016866;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;tetrapyrrole binding#GO:0046906;isomerase activity#GO:0016853;heterocyclic compound binding#GO:1901363 organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;sulfur compound catabolic process#GO:0044273;purine-containing compound catabolic process#GO:0072523;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;lipid catabolic process#GO:0016042;nucleobase-containing compound metabolic process#GO:0006139 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 isomerase#PC00135;metabolite interconversion enzyme#PC00262;mutase#PC00160 Methylmalonyl pathway#P02755>Methylmalonyl-CoA mutase#P03034;Succinate to proprionate conversion#P02777>Methylmalonyl-CoA mutase#P03161 HELRO|EnsemblGenome=HelroG73524|UniProtKB=T1G1F2 T1G1F2 20214900 PTHR23131:SF6 ENDORIBONUCLEASE LACTB2 ENDORIBONUCLEASE LACTB2 single-stranded RNA binding#GO:0003727;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG166309|UniProtKB=T1EY02 T1EY02 20201452 PTHR22802:SF396 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114981|UniProtKB=T1EG56 T1EG56 20195558 PTHR15336:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL electron transport chain#GO:0022900;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060 respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex III#GO:0045275;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174821|UniProtKB=T1F8I6 T1F8I6 20205135 PTHR10075:SF130 BASIGIN RELATED NEURAL CELL ADHESION MOLECULE L1 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG116074|UniProtKB=T1EGC7 T1EGC7 20195629 PTHR10177:SF615 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-A protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle G1/S phase transition#GO:0044843;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;protein kinase complex#GO:1902911;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG178116|UniProtKB=T1FCR6 T1FCR6 20206615 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;chromosome#GO:0005694;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG91084|UniProtKB=T1G7Z6 T1G7Z6 20217193 PTHR18847:SF0 20 KD NUCLEAR CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nuclear export#GO:0051168;nuclear transport#GO:0051169;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions#GO:0000375;establishment of RNA localization#GO:0051236;RNA biosynthetic process#GO:0032774;mRNA transport#GO:0051028;RNA transport#GO:0050658;regulation of cellular process#GO:0050794;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;nitrogen compound transport#GO:0071705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule localization#GO:0033036;nucleobase-containing compound catabolic process#GO:0034655;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;RNA splicing#GO:0008380;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mRNA processing#GO:0006397;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162810|UniProtKB=T1ET72 T1ET72 20199772 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG188039|UniProtKB=T1FPK6 T1FPK6 20210753 PTHR32122:SF1 TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A General transcription by RNA polymerase I#P00022>TAF-IA#P00651;General transcription by RNA polymerase I#P00022>SL1 complex#P00653 HELRO|EnsemblGenome=HelroG116524|UniProtKB=T1EGF6 T1EGF6 20195658 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HB1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG161143|UniProtKB=T1ER51 T1ER51 20199051 PTHR46439:SF3 CYSTEINE-RICH MOTOR NEURON 1 PROTEIN RE54525P HELRO|EnsemblGenome=HelroG185395|UniProtKB=T1FMR5 T1FMR5 20210114 PTHR45709:SF3 LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 HELRO|EnsemblGenome=HelroG81128|UniProtKB=T1G497 T1G497 20215895 PTHR24291:SF48 CYTOCHROME P450 FAMILY 4 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG92768|UniProtKB=T1G8K7 T1G8K7 20217404 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74446|UniProtKB=T1G1R2 T1G1R2 20215010 PTHR23257:SF1008 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91231|UniProtKB=T1G814 T1G814 20217211 PTHR11225:SF4 NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN NUCLEAR PORE COMPLEX PROTEIN NUP93 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;gene expression#GO:0010467;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;protein transport#GO:0015031;protein import into nucleus#GO:0006606;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle envelope#GO:0031967 transporter#PC00227 HELRO|EnsemblGenome=HelroG114208|UniProtKB=T1EG01 T1EG01 20195503 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;carbohydrate transmembrane transport#GO:0034219;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transport#GO:0008643 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG81201|UniProtKB=T1G4B1 T1G4B1 20215909 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG166584|UniProtKB=T1EY99 T1EY99 20201549 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88370|UniProtKB=T1G717 T1G717 20216864 PTHR24393:SF183 ZINC FINGER PROTEIN LD28458P-RELATED nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG84684|UniProtKB=T1G5M1 T1G5M1 20216368 PTHR13902:SF177 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED SERINE_THREONINE-PROTEIN KINASE WNK kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;transferase activity#GO:0016740;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247;phosphotransferase activity, alcohol group as acceptor#GO:0016773 signaling#GO:0023052;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;negative regulation of transport#GO:0051051;regulation of metal ion transport#GO:0010959;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;negative regulation of biological process#GO:0048519;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of transport#GO:0051050;monoatomic ion homeostasis#GO:0050801;regulation of transport#GO:0051049;regulation of localization#GO:0032879;chemical homeostasis#GO:0048878;regulation of monoatomic cation transmembrane transport#GO:1904062 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG121890|UniProtKB=T1EGT0 T1EGT0 20195780 PTHR43876:SF7 UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;ubiquinone biosynthetic process#GO:0006744;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ketone metabolic process#GO:0042180 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG175503|UniProtKB=T1F9C1 T1F9C1 20205420 PTHR43011:SF1 IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL iron ion binding#GO:0005506;cation binding#GO:0043169;iron-sulfur cluster binding#GO:0051536;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;iron-sulfur cluster assembly#GO:0016226;protein maturation#GO:0051604;gene expression#GO:0010467;cellular component assembly#GO:0022607;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG138329|UniProtKB=T1EIT9 T1EIT9 20196489 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG181343|UniProtKB=T1FGX0 T1FGX0 20208069 PTHR10829:SF25 CORTACTIN AND DREBRIN COACTOSIN-LIKE PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779 regulation of actin filament polymerization#GO:0030833;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure size#GO:0090066;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component biogenesis#GO:0044087;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832 intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG156425|UniProtKB=T1ELW3 T1ELW3 20197563 PTHR20917:SF1 PNAS-RELATED CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085 intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;calcium ion homeostasis#GO:0055074;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HELRO|EnsemblGenome=HelroG189935|UniProtKB=T1FRI0 T1FRI0 20211427 PTHR10182:SF3 CALCIUM-BINDING PROTEIN 39-RELATED PROTEIN MO25 protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 HELRO|EnsemblGenome=HelroG169858|UniProtKB=T1F2D7 T1F2D7 20202987 PTHR46154:SF4 FAMILY NOT NAMED UREA TRANSPORTER HELRO|EnsemblGenome=HelroG95527|UniProtKB=T1G966 T1G966 20217613 PTHR19375:SF438 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 14 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;ribonucleoside triphosphate phosphatase activity#GO:0017111 protein refolding#GO:0042026;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 ribosome#GO:0005840;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chaperone#PC00072;Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG185194|UniProtKB=T1FMH7 T1FMH7 20210026 PTHR11778:SF7 SERYL-TRNA SYNTHETASE SERINE--TRNA LIGASE, CYTOPLASMIC binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG121833|UniProtKB=T1EGS9 T1EGS9 20195779 PTHR19960:SF11 TEKTIN LD08455P cell motility#GO:0048870;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG108931|UniProtKB=T1EEN9 T1EEN9 20195041 PTHR42687:SF1 L-THREONINE 3-DEHYDROGENASE L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192765|UniProtKB=T1FU98 T1FU98 20212394 PTHR16219:SF3 AUGMIN SUBUNIT 4 FAMILY MEMBER HAUS AUGMIN-LIKE COMPLEX SUBUNIT 4 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652 HELRO|EnsemblGenome=HelroG159812|UniProtKB=T1EPF3 T1EPF3 20198453 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG122255|UniProtKB=T1EGU3 T1EGU3 20195793 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843 import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HELRO|EnsemblGenome=HelroG160962|UniProtKB=T1EQX2 T1EQX2 20198972 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159700|UniProtKB=T1EPB9 T1EPB9 20198419 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;regulation of RNA stability#GO:0043487;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of mRNA metabolic process#GO:1903311;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;metabolic process#GO:0008152 intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 HELRO|EnsemblGenome=HelroG179844|UniProtKB=T1FF74 T1FF74 20207473 PTHR12271:SF141 POLY A POLYMERASE CID PAP -RELATED TERMINAL URIDYLYLTRANSFERASE TAILOR transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG182594|UniProtKB=T1FIF6 T1FIF6 20208605 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179724|UniProtKB=T1FF29 T1FF29 20207428 PTHR15431:SF19 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTROSOMAL PROTEIN 20 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815 HELRO|EnsemblGenome=HelroG166424|UniProtKB=T1EY44 T1EY44 20201494 PTHR46647:SF1 RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS HELRO|EnsemblGenome=HelroG185731|UniProtKB=T1FN77 T1FN77 20210275 PTHR11615:SF377 NITRATE, FORMATE, IRON DEHYDROGENASE NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;monoatomic cation transmembrane transporter activity#GO:0008324;oxidoreductase activity, acting on NAD(P)H#GO:0016651;electron transfer activity#GO:0009055;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;primary active transmembrane transporter activity#GO:0015399;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;active transmembrane transporter activity#GO:0022804;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075 mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle membrane#GO:0031090;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG157789|UniProtKB=T1EMF8 T1EMF8 20197758 PTHR24247:SF202 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888 cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537 cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;dendritic tree#GO:0097447;dendrite#GO:0030425 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG99560|UniProtKB=T1G9T6 T1G9T6 20217832 PTHR23077:SF202 AAA-FAMILY ATPASE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94 hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;modification-dependent protein binding#GO:0140030;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;polyubiquitin modification-dependent protein binding#GO:0031593;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;autophagy#GO:0006914;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;cytoskeleton organization#GO:0007010;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;cell cycle process#GO:0022402;cellular component organization#GO:0016043;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;transport#GO:0006810;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;autophagosome maturation#GO:0097352;mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;spindle organization#GO:0007051;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;macroautophagy#GO:0016236;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;localization#GO:0051179;protein metabolic process#GO:0019538;microtubule cytoskeleton organization#GO:0000226;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;microtubule cytoskeleton organization involved in mitosis#GO:1902850;protein-containing complex disassembly#GO:0032984;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056 membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytosol#GO:0005829;nucleus#GO:0005634;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG194458|UniProtKB=T1FW27 T1FW27 20213023 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG70655|UniProtKB=T1G099 T1G099 20214497 PTHR24070:SF69 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY FI18258P1 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG177007|UniProtKB=T1FB48 T1FB48 20206047 PTHR11066:SF34 ACYL-COA THIOESTERASE ACYL-COENZYME A THIOESTERASE 8 hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;deacylase activity#GO:0160215;acyl-CoA hydrolase activity#GO:0016289;catalytic activity#GO:0003824;fatty acyl-CoA hydrolase activity#GO:0047617;hydrolase activity#GO:0016787 fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;monocarboxylic acid catabolic process#GO:0072329;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042 peroxisome#GO:0005777;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;esterase#PC00097;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187047|UniProtKB=T1FP62 T1FP62 20210609 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;homeostatic process#GO:0042592;export from cell#GO:0140352;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;inorganic ion homeostasis#GO:0098771;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG187858|UniProtKB=T1FPF7 T1FPF7 20210704 PTHR20275:SF44 NAD KINASE NAD KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;pyridine-containing compound metabolic process#GO:0072524;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;NADP+ metabolic process#GO:0006739;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 nucleotide kinase#PC00172 HELRO|EnsemblGenome=HelroG89246|UniProtKB=T1G7A9 T1G7A9 20216956 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG191412|UniProtKB=T1FSY7 T1FSY7 20211934 PTHR44414:SF1 PROTEIN NEDD1 PROTEIN NEDD1 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;mitotic cell cycle#GO:0000278;microtubule nucleation#GO:0007020;cell cycle#GO:0007049;cellular component organization#GO:0016043;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435 spindle pole#GO:0000922;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG183804|UniProtKB=T1FK78 T1FK78 20209227 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166903|UniProtKB=T1EYQ7 T1EYQ7 20201707 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG66720|UniProtKB=T1FYP2 T1FYP2 20213940 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG168718|UniProtKB=T1F0W1 T1F0W1 20202461 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171313|UniProtKB=T1F433 T1F433 20203582 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN hormone binding#GO:0042562;binding#GO:0005488;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169254|UniProtKB=T1F1N1 T1F1N1 20202731 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102065|UniProtKB=T1ED78 T1ED78 20194530 PTHR46550:SF7 F-BOX ONLY PROTEIN 3 F-BOX ONLY PROTEIN 3 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG173545|UniProtKB=T1F6Y8 T1F6Y8 20204587 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83594|UniProtKB=T1G577 T1G577 20216225 PTHR10257:SF3 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WELL-ROUNDED, ISOFORM B enzyme activator activity#GO:0008047;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629;Wnt signaling pathway#P00057>PP2A#P01438;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG168889|UniProtKB=T1F136 T1F136 20202536 PTHR14167:SF92 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184743|UniProtKB=T1FLW9 T1FLW9 20209818 PTHR24228:SF59 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR NEUROPEPTIDE RECEPTOR 15 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG165086|UniProtKB=T1EW99 T1EW99 20200849 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG110821|UniProtKB=T1EF54 T1EF54 20195206 PTHR47368:SF2 NUMB NUMB cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG129809|UniProtKB=T1EHS3 T1EHS3 20196123 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987;response to radiation#GO:0009314;signal transduction#GO:0007165;detection of stimulus#GO:0051606;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214;signaling#GO:0023052;cellular response to radiation#GO:0071478;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG175015|UniProtKB=T1F8Q5 T1F8Q5 20205204 PTHR22848:SF0 WD40 REPEAT PROTEIN WD40 REPEAT-CONTAINING PROTEIN SMU1 biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG181106|UniProtKB=T1FGM1 T1FGM1 20207970 PTHR10465:SF3 TRANSMEMBRANE GTPASE FZO1 TRANSMEMBRANE GTPASE MARF-RELATED hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular component organization#GO:0016043;mitochondrial fusion#GO:0008053;organelle organization#GO:0006996;cellular process#GO:0009987;organelle fusion#GO:0048284;mitochondrion organization#GO:0007005;organelle localization#GO:0051640;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;mitochondrion localization#GO:0051646 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741 HELRO|EnsemblGenome=HelroG108365|UniProtKB=T1EEI5 T1EEI5 20194987 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG183494|UniProtKB=T1FJR4 T1FJR4 20209063 PTHR21646:SF76 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32 catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;regulation of protein stability#GO:0031647;positive regulation of cellular process#GO:0048522;regulation of TOR signaling#GO:0032006;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;regulation of biological quality#GO:0065008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG173369|UniProtKB=T1F6Q5 T1F6Q5 20204504 PTHR14038:SF0 BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2 LP18708P binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181936|UniProtKB=T1FHH1 T1FHH1 20208270 PTHR10909:SF250 ELECTRON TRANSPORT OXIDOREDUCTASE ACYL-COENZYME A OXIDASE-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;lipid binding#GO:0008289 lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183488|UniProtKB=T1FJR2 T1FJR2 20209061 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172540|UniProtKB=T1F5H4 T1F5H4 20204073 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG190849|UniProtKB=T1FSD1 T1FSD1 20211728 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG65459|UniProtKB=T1FY80 T1FY80 20213778 PTHR21562:SF122 NOTUM-RELATED PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM HELRO|EnsemblGenome=HelroG178754|UniProtKB=T1FDP0 T1FDP0 20206939 PTHR47148:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG95790|UniProtKB=T1G976 T1G976 20217623 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG65703|UniProtKB=T1FYB7 T1FYB7 20213815 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160782|UniProtKB=T1EQQ1 T1EQQ1 20198901 PTHR24133:SF60 ANKYRIN DOMAIN-CONTAINING ANKYRIN REPEAT AND SOCS BOX-CONTAINING 3 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173706|UniProtKB=T1F752 T1F752 20204651 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG66308|UniProtKB=T1FYJ6 T1FYJ6 20213894 PTHR24543:SF339 MULTICOPPER OXIDASE-RELATED LACTADHERIN-LIKE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191389|UniProtKB=T1FSY3 T1FSY3 20211930 PTHR15427:SF58 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176988|UniProtKB=T1FB36 T1FB36 20206035 PTHR21041:SF17 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE DCST1 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 fertilization#GO:0009566;reproductive process#GO:0022414;single fertilization#GO:0007338;cellular process#GO:0009987;cell-cell recognition#GO:0009988;sperm-egg recognition#GO:0035036;cell recognition#GO:0008037;sexual reproduction#GO:0019953 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669 HELRO|EnsemblGenome=HelroG184710|UniProtKB=T1FLU0 T1FLU0 20209789 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG173479|UniProtKB=T1F6V4 T1F6V4 20204553 PTHR45661:SF3 SURFACE ANTIGEN LEUCINE RICH REPEAT PROTEIN HELRO|EnsemblGenome=HelroG64105|UniProtKB=T1FXP2 T1FXP2 20213590 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN 7, ISOFORM A SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488;protein binding#GO:0005515;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;membrane organization#GO:0061024;biological regulation#GO:0065007;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;transport#GO:0006810;regulation of transport#GO:0051049;regulation of localization#GO:0032879;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;localization#GO:0051179 membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG182937|UniProtKB=T1FIY0 T1FIY0 20208779 PTHR23418:SF0 ACIREDUCTONE DIOXYGENASE ACIREDUCTONE DIOXYGENASE oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG100818|UniProtKB=T1ED17 T1ED17 20194469 PTHR11210:SF1 RING BOX ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of chromosome segregation#GO:0051983;positive regulation of mitotic nuclear division#GO:0045840;regulation of chromosome separation#GO:1905818;protein ubiquitination#GO:0016567;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of organelle organization#GO:0010638;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of cellular component organization#GO:0051130;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;regulation of organelle organization#GO:0033043;macromolecule metabolic process#GO:0043170;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of mitotic cell cycle#GO:0045931;regulation of chromosome organization#GO:0033044;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;post-translational protein modification#GO:0043687;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941 anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG186259|UniProtKB=T1FNV8 T1FNV8 20210505 PTHR24089:SF59 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER organophosphate ester transmembrane transporter activity#GO:0015605;quaternary ammonium group transmembrane transporter activity#GO:0015651;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;vitamin transport#GO:0051180;organophosphate ester transport#GO:0015748;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;quaternary ammonium group transport#GO:0015697 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HELRO|EnsemblGenome=HelroG67429|UniProtKB=T1FZ08 T1FZ08 20214056 PTHR11630:SF66 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM4 catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697 double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA strand elongation involved in DNA replication#GO:0006271;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;cellular process#GO:0009987;double-strand break repair via break-induced replication#GO:0000727;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA repair#GO:0006281;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nuclear DNA replication#GO:0033260;mitotic DNA replication#GO:1902969;mitotic cell cycle process#GO:1903047;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;MCM complex#GO:0042555;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG160527|UniProtKB=T1EQD0 T1EQD0 20198780 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 HELRO|EnsemblGenome=HelroG64188|UniProtKB=T1FXR1 T1FXR1 20213609 PTHR12378:SF7 DESUMOYLATING ISOPEPTIDASE DESUMOYLATING ISOPEPTIDASE 1 biological regulation#GO:0065007;protein export from nucleus#GO:0006611;regulation of proteasomal protein catabolic process#GO:0061136;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;intracellular protein localization#GO:0008104;regulation of catabolic process#GO:0009894;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;nuclear transport#GO:0051169;nuclear export#GO:0051168;protein transport#GO:0015031;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG181730|UniProtKB=T1FH95 T1FH95 20208194 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;galactosyltransferase activity#GO:0008378 transferase#PC00220 HELRO|EnsemblGenome=HelroG121109|UniProtKB=T1EGR0 T1EGR0 20195760 PTHR13906:SF4 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 6 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 lipid modification#GO:0030258;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629 membrane#GO:0016020;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG63336|UniProtKB=T1FXE4 T1FXE4 20213492 PTHR11909:SF300 CASEIN KINASE-RELATED TAU-TUBULIN KINASE HOMOLOG ASATOR protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG160414|UniProtKB=T1EQ80 T1EQ80 20198730 PTHR23248:SF9 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810;lipid transport#GO:0006869;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;macromolecule localization#GO:0033036;cellular process#GO:0009987;plasma membrane organization#GO:0007009;localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;organophosphate ester transport#GO:0015748;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;cellular component organization#GO:0016043 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG173544|UniProtKB=T1F6Y7 T1F6Y7 20204586 PTHR11046:SF0 OLIGORIBONUCLEASE, MITOCHONDRIAL OLIGORIBONUCLEASE, MITOCHONDRIAL RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181580|UniProtKB=T1FH47 T1FH47 20208146 PTHR14754:SF34 TRANSCRIPTION ELONGATION FACTOR A TRICHOHYALIN general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG87515|UniProtKB=T1G6R4 T1G6R4 20216761 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG171983|UniProtKB=T1F4W9 T1F4W9 20203868 PTHR31802:SF54 32 KDA HEAT SHOCK PROTEIN-RELATED MARTIK, ISOFORM A-RELATED membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG64665|UniProtKB=T1FXX7 T1FXX7 20213675 PTHR23257:SF1008 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85971|UniProtKB=T1G652 T1G652 20216549 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;metabolic process#GO:0008152;proteolysis#GO:0006508;catabolic process#GO:0009056;primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG65297|UniProtKB=T1FY57 T1FY57 20213755 PTHR47634:SF26 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED SERINE-ARGININE PROTEIN KINASE AT 79D-RELATED protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;regulation of mRNA metabolic process#GO:1903311;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG151843|UniProtKB=T1EKM3 T1EKM3 20197123 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG192456|UniProtKB=T1FTZ5 T1FTZ5 20212292 PTHR22791:SF6 RING-TYPE DOMAIN-CONTAINING PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG160493|UniProtKB=T1EQB3 T1EQB3 20198763 PTHR28608:SF1 INTEGRATOR COMPLEX SUBUNIT 2 INTEGRATOR COMPLEX SUBUNIT 2 nucleobase-containing compound catabolic process#GO:0034655;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;snRNA processing#GO:0016180;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription initiation#GO:0006352;catabolic process#GO:0009056;DNA-templated transcription#GO:0006351;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;integrator complex#GO:0032039;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG192507|UniProtKB=T1FU12 T1FU12 20212308 PTHR19134:SF570 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;developmental process#GO:0032502;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG124583|UniProtKB=T1EH19 T1EH19 20195869 PTHR39074:SF1 AGAP007547-PA SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG159935|UniProtKB=T1EPK8 T1EPK8 20198508 PTHR16484:SF17 PARTITIONING DEFECTIVE 3 RELATED BAZOOKA, ISOFORM B small molecule binding#GO:0036094;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167 cytoskeleton organization#GO:0007010;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of bipolar cell polarity#GO:0061245;cell adhesion#GO:0007155 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;apical plasma membrane#GO:0016324;membrane#GO:0016020;cell-cell junction#GO:0005911;cell cortex#GO:0005938;cell periphery#GO:0071944;cell junction#GO:0030054;adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;apical junction complex#GO:0043296;apical part of cell#GO:0045177 HELRO|EnsemblGenome=HelroG194856|UniProtKB=T1FWH9 T1FWH9 20213174 PTHR22624:SF49 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;protein-phosphatidylethanolamide deconjugating activity#GO:0019786;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;proteolysis#GO:0006508;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;autophagosome organization#GO:1905037;cellular process#GO:0009987;protein processing#GO:0016485;autophagy#GO:0006914;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular component assembly#GO:0022607;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;macromolecule metabolic process#GO:0043170;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG191305|UniProtKB=T1FSV2 T1FSV2 20211899 PTHR10663:SF376 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PH AND SEC7 DOMAIN-CONTAINING PROTEIN cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;ruffle#GO:0001726 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG150697|UniProtKB=T1EKG9 T1EKG9 20197069 PTHR23308:SF36 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 SMAD NUCLEAR-INTERACTING PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG191008|UniProtKB=T1FSH7 T1FSH7 20211774 PTHR19854:SF15 TRANSDUCIN BETA-LIKE 3 TRANSDUCIN BETA-LIKE PROTEIN 3 RNA binding#GO:0003723;U3 snoRNA binding#GO:0034511;binding#GO:0005488;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515 biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 90S preribosome#GO:0030686;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192266|UniProtKB=T1FTS0 T1FTS0 20212217 PTHR23003:SF71 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nuclear mRNA surveillance#GO:0071028;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG175332|UniProtKB=T1F955 T1F955 20205354 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159857|UniProtKB=T1EPH1 T1EPH1 20198471 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 transferase#PC00220 HELRO|EnsemblGenome=HelroG72187|UniProtKB=T1G0X0 T1G0X0 20214718 PTHR20844:SF0 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9 RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG106742|UniProtKB=T1EE45 T1EE45 20194847 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG74437|UniProtKB=T1G1R1 T1G1R1 20215009 PTHR23137:SF36 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN SFT2C HELRO|EnsemblGenome=HelroG193759|UniProtKB=T1FVB8 T1FVB8 20212764 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG89643|UniProtKB=T1G7F4 T1G7F4 20217001 PTHR21547:SF0 CLUSTERIN ASSOCIATED PROTEIN 1 CLUSTERIN-ASSOCIATED PROTEIN 1 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987 intraciliary transport particle B#GO:0030992;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG79367|UniProtKB=T1G3N3 T1G3N3 20215681 PTHR45810:SF18 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG165351|UniProtKB=T1EWM3 T1EWM3 20200973 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG68472|UniProtKB=T1FZF2 T1FZF2 20214200 PTHR24247:SF191 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;acetylcholine receptor activity#GO:0015464;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594 signaling#GO:0023052;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;trans-synaptic signaling#GO:0099537;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447;cell junction#GO:0030054 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG75913|UniProtKB=T1G2C6 T1G2C6 20215224 PTHR12612:SF48 NUCLEAR TRANSPORT FACTOR 2 NUCLEAR TRANSPORT FACTOR 2 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967 HELRO|EnsemblGenome=HelroG154673|UniProtKB=T1ELF5 T1ELF5 20197405 PTHR11142:SF4 PSEUDOURIDYLATE SYNTHASE PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG isomerase activity#GO:0016853;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA modification#GO:0016556;pseudouridine synthesis#GO:0001522;tRNA modification#GO:0006400;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 lyase#PC00144 HELRO|EnsemblGenome=HelroG181429|UniProtKB=T1FH01 T1FH01 20208100 PTHR21501:SF1 PROTEIN FAM-161 PROTEIN FAM-161 cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG171893|UniProtKB=T1F4T2 T1F4T2 20203831 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;spindle localization#GO:0051653;establishment or maintenance of cell polarity#GO:0007163;organelle localization#GO:0051640;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of establishment or maintenance of cell polarity#GO:0032878;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;mitotic cell cycle process#GO:1903047;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG69589|UniProtKB=T1FZW9 T1FZW9 20214367 PTHR12345:SF3 SYNTENIN RELATED SYNTENIN-1-LIKE PROTEIN cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG183188|UniProtKB=T1FJ99 T1FJ99 20208898 PTHR48540:SF1 FAMILY NOT NAMED GLYCINE-RICH PROTEIN HELRO|EnsemblGenome=HelroG78789|UniProtKB=T1G3F9 T1G3F9 20215607 PTHR21377:SF0 PROTEIN FAM210B, MITOCHONDRIAL PROTEIN FAM210B, MITOCHONDRIAL organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG185356|UniProtKB=T1FMQ2 T1FMQ2 20210101 PTHR23030:SF39 PCD6 INTERACTING PROTEIN-RELATED PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;endosomal transport#GO:0016197;cell cycle process#GO:0022402;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;cytokinesis#GO:0000910;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular localization#GO:0051641;cytoskeleton-dependent cytokinesis#GO:0061640;protein transport#GO:0015031;macromolecule localization#GO:0033036;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;mitotic cell cycle process#GO:1903047;primary metabolic process#GO:0044238;cell cycle#GO:0007049;cell division#GO:0051301;modification-dependent protein catabolic process#GO:0019941;mitotic cytokinesis#GO:0000281;protein localization to organelle#GO:0033365;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177642|UniProtKB=T1FBZ8 T1FBZ8 20206347 PTHR45798:SF108 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186292|UniProtKB=T1FNX7 T1FNX7 20210524 PTHR12658:SF1 BETA-TUBULIN COFACTOR D TUBULIN-SPECIFIC CHAPERONE D enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;cytoskeleton organization#GO:0007010;metabolic process#GO:0008152;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cell junction organization#GO:0034330;protein folding#GO:0006457;protein metabolic process#GO:0019538;microtubule cytoskeleton organization#GO:0000226 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG163804|UniProtKB=T1EUH6 T1EUH6 20200226 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63467|UniProtKB=T1FXG2 T1FXG2 20213510 PTHR45815:SF3 PROTEIN DISULFIDE-ISOMERASE A6 PROTEIN DISULFIDE-ISOMERASE A6 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 response to stimulus#GO:0050896;response to stress#GO:0006950;response to endoplasmic reticulum stress#GO:0034976;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 chaperone#PC00072 HELRO|EnsemblGenome=HelroG88593|UniProtKB=T1G742 T1G742 20216889 PTHR12980:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X CYTOCHROME B-C1 COMPLEX SUBUNIT 9 cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119 respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex III#GO:0045275;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG186550|UniProtKB=T1FP10 T1FP10 20210557 PTHR19920:SF0 WD40 PROTEIN CIAO1 CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;iron-sulfur cluster assembly#GO:0016226;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG109895|UniProtKB=T1EEX2 T1EEX2 20195124 PTHR12213:SF0 CORRINOID ADENOSYLTRANSFERASE CORRINOID ADENOSYLTRANSFERASE MMAB catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG164778|UniProtKB=T1EVS9 T1EVS9 20200679 PTHR45624:SF24 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN G transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transporter#PC00227 HELRO|EnsemblGenome=HelroG172364|UniProtKB=T1F584 T1F584 20203983 PTHR13475:SF6 NEUGRIN FI11059P cellular process#GO:0009987;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;ribonucleoprotein complex biogenesis#GO:0022613;cellular component assembly#GO:0022607;ribosome biogenesis#GO:0042254;organelle assembly#GO:0070925;ribosome assembly#GO:0042255;mitochondrial ribosome assembly#GO:0061668;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG178471|UniProtKB=T1FD79 T1FD79 20206778 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG163490|UniProtKB=T1EU45 T1EU45 20200095 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG194040|UniProtKB=T1FVL5 T1FVL5 20212861 PTHR13393:SF0 SAM-DEPENDENT METHYLTRANSFERASE RNA N(6)-ADENOSINE-METHYLTRANSFERASE METTL16 RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;post-transcriptional regulation of gene expression#GO:0010608;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;mRNA processing#GO:0006397;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG133970|UniProtKB=T1EI30 T1EI30 20196230 PTHR20948:SF2 TRANSMEMBRANE PROTEIN 164 RH09039P HELRO|EnsemblGenome=HelroG67587|UniProtKB=T1FZ26 T1FZ26 20214074 PTHR20914:SF9 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8 UPAR_LY6 DOMAIN-CONTAINING PROTEIN COLD scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166191|UniProtKB=T1EXV9 T1EXV9 20201409 PTHR14739:SF9 MICROTUBULE-ASSOCIATED PROTEIN 9 MICROTUBULE-ASSOCIATED PROTEIN 9 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;regulation of cell cycle#GO:0051726;mitotic spindle organization#GO:0007052;nuclear division#GO:0000280;regulation of cytokinesis#GO:0032465;regulation of mitotic cytokinesis#GO:1902412;mitotic spindle assembly#GO:0090307;mitotic sister chromatid segregation#GO:0000070;biological regulation#GO:0065007;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;spindle organization#GO:0007051;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;organelle assembly#GO:0070925;regulation of cell division#GO:0051302;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226 cytoskeleton#GO:0005856;spindle#GO:0005819;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG182704|UniProtKB=T1FIL9 T1FIL9 20208668 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162948|UniProtKB=T1ETE6 T1ETE6 20199846 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87454|UniProtKB=T1G6Q3 T1G6Q3 20216750 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 macromolecule localization#GO:0033036;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of localization#GO:0032879;regulation of transport#GO:0051049;intracellular protein localization#GO:0008104;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;regulation of secretion by cell#GO:1903530;localization#GO:0051179;regulation of secretion#GO:0051046 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG82387|UniProtKB=T1G4R6 T1G4R6 20216064 PTHR24068:SF567 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG76326|UniProtKB=T1G2I4 T1G2I4 20215282 PTHR10257:SF5 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WIDERBORST, ISOFORM H phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888;enzyme activator activity#GO:0008047 cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;sister chromatid cohesion#GO:0007062;negative regulation of cell communication#GO:0010648;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG152187|UniProtKB=T1EKQ0 T1EKQ0 20197150 PTHR15283:SF4 GREMLIN 1 CTCK DOMAIN-CONTAINING PROTEIN binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine binding#GO:0019955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG192854|UniProtKB=T1FUD1 T1FUD1 20212427 PTHR15507:SF17 ZINC FINGER PROTEIN RLF ZINC FINGER PROTEIN 40 transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG130721|UniProtKB=T1EHU5 T1EHU5 20196145 PTHR45646:SF2 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE PROTEIN KINASE AFUA_5G14870 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG151661|UniProtKB=T1EKL5 T1EKL5 20197115 PTHR19308:SF59 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN PHOSPHATIDYLCHOLINE TRANSFER PROTEIN phosphatidylcholine intramembrane carrier activity#GO:0008525;molecular carrier activity#GO:0140104;ion binding#GO:0043167;lipid carrier activity#GO:0005319;binding#GO:0005488;small molecule binding#GO:0036094;intramembrane lipid carrier activity#GO:0140303;lipid binding#GO:0008289;cation binding#GO:0043169;phospholipid binding#GO:0005543;transporter activity#GO:0005215;phosphatidylcholine binding#GO:0031210 HELRO|EnsemblGenome=HelroG172775|UniProtKB=T1F5X5 T1F5X5 20204224 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189853|UniProtKB=T1FRF3 T1FRF3 20211400 PTHR13220:SF11 TIMELESS INTERACTING-RELATED TIMELESS-INTERACTING PROTEIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of DNA metabolic process#GO:0051052;DNA replication#GO:0006260;regulation of DNA-templated DNA replication#GO:0090329;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;DNA-templated DNA replication#GO:0006261;regulation of DNA replication#GO:0006275;cellular response to stress#GO:0033554;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of primary metabolic process#GO:0080090;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;negative regulation of DNA-templated DNA replication#GO:2000104;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;replication fork#GO:0005657;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG179028|UniProtKB=T1FE26 T1FE26 20207075 PTHR11339:SF416 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED HEMOLECTIN, ISOFORM A extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG190631|UniProtKB=T1FS57 T1FS57 20211654 PTHR10855:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4 COP9 SIGNALOSOME COMPLEX SUBUNIT 4 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 protease#PC00190 HELRO|EnsemblGenome=HelroG135380|UniProtKB=T1EI84 T1EI84 20196284 PTHR13610:SF9 METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN ATP SYNTHASE SUBUNIT C LYSINE N-METHYLTRANSFERASE protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG114357|UniProtKB=T1EG09 T1EG09 20195511 PTHR43272:SF116 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE 1 ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;ligase activity#GO:0016874 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 ligase#PC00142 HELRO|EnsemblGenome=HelroG82800|UniProtKB=T1G4W8 T1G4W8 20216116 PTHR12289:SF38 METAXIN RELATED METAXIN-2 localization within membrane#GO:0051668;protein insertion into mitochondrial outer membrane#GO:0045040;localization#GO:0051179;cellular localization#GO:0051641;protein-containing complex assembly#GO:0065003;protein localization to mitochondrion#GO:0070585;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;establishment of protein localization to membrane#GO:0090150;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;protein insertion into membrane#GO:0051205 mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial outer membrane translocase complex#GO:0005742;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG87830|UniProtKB=T1G6W0 T1G6W0 20216807 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG79786|UniProtKB=T1G3T3 T1G3T3 20215731 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HELRO|EnsemblGenome=HelroG173497|UniProtKB=T1F6W3 T1F6W3 20204562 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG75788|UniProtKB=T1G2A2 T1G2A2 20215200 PTHR11038:SF16 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;organelle organization#GO:0006996;protein insertion into mitochondrial inner membrane#GO:0045039;membrane organization#GO:0061024;mitochondrial protein import pathway#GO:7770058;mitochondrion organization#GO:0007005;transport#GO:0006810;intracellular transport#GO:0046907;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular component organization#GO:0016043;mitochondrial transport#GO:0006839;localization#GO:0051179;cellular localization#GO:0051641 mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;TIM22 mitochondrial import inner membrane insertion complex#GO:0042721;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG177979|UniProtKB=T1FCK2 T1FCK2 20206551 PTHR19411:SF0 PROTEIN BUD31-RELATED PROTEIN BUD31 HOMOLOG RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG95960|UniProtKB=T1G992 T1G992 20217639 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG186120|UniProtKB=T1FNP3 T1FNP3 20210440 PTHR11999:SF167 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE AROMATIC-L-AMINO-ACID DECARBOXYLASE carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;lyase activity#GO:0016829 metabolic process#GO:0008152;catecholamine metabolic process#GO:0006584;serotonin metabolic process#GO:0042428;amine metabolic process#GO:0009308;phenol-containing compound biosynthetic process#GO:0046189;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;phenol-containing compound metabolic process#GO:0018958;serotonin biosynthetic process#GO:0042427;biosynthetic process#GO:0009058;biogenic amine metabolic process#GO:0006576 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 lyase#PC00144;decarboxylase#PC00089 Nicotine pharmacodynamics pathway#P06587>DDC#P06608;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961;Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066;5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400 HELRO|EnsemblGenome=HelroG174251|UniProtKB=T1F7W0 T1F7W0 20204909 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG165334|UniProtKB=T1EWL7 T1EWL7 20200967 PTHR23320:SF130 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED TRANSMEMBRANE PROTEIN 212 transporter#PC00227 HELRO|EnsemblGenome=HelroG64858|UniProtKB=T1FY04 T1FY04 20213702 PTHR45948:SF2 DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED DUAL SPECIFICITY PROTEIN PHOSPHATASE 15 protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG76395|UniProtKB=T1G2J6 T1G2J6 20215294 PTHR23055:SF201 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG111641|UniProtKB=T1EFD2 T1EFD2 20195284 PTHR22808:SF3 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING NOL1_NOP2_SUN DOMAIN FAMILY MEMBER 4 catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;RNA processing#GO:0006396;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG181470|UniProtKB=T1FH13 T1FH13 20208112 PTHR10019:SF13 SNF5 PB1 DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG182104|UniProtKB=T1FHR5 T1FHR5 20208364 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG162227|UniProtKB=T1ESD7 T1ESD7 20199487 PTHR24418:SF474 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG102250|UniProtKB=T1ED89 T1ED89 20194541 PTHR13678:SF27 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 LD45836P establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein transport#GO:0015031;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting to vacuole#GO:0006623;intracellular protein transport#GO:0006886;protein targeting to membrane#GO:0006612;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;protein localization to vacuole#GO:0072665;localization#GO:0051179;protein metabolic process#GO:0019538;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG195045|UniProtKB=T1FWP6 T1FWP6 20213241 PTHR11506:SF35 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5 localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;late endosome membrane#GO:0031902;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;lysosomal membrane#GO:0005765 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG179029|UniProtKB=T1FE27 T1FE27 20207076 PTHR11339:SF416 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED HEMOLECTIN, ISOFORM A extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG180249|UniProtKB=T1FFM7 T1FFM7 20207626 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180052|UniProtKB=T1FFE6 T1FFE6 20207545 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune system process#GO:0002376 extracellular region#GO:0005576;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG108967|UniProtKB=T1EEP4 T1EEP4 20195046 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG102273|UniProtKB=T1ED91 T1ED91 20194543 PTHR12686:SF8 3'-5' EXORIBONUCLEASE CSL4-RELATED EXOSOME COMPLEX COMPONENT CSL4 negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;rRNA processing#GO:0006364;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;regulation of biological process#GO:0050789;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;maturation of 5.8S rRNA#GO:0000460;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG186194|UniProtKB=T1FNS9 T1FNS9 20210476 PTHR21539:SF0 SAGA-ASSOCIATED FACTOR 29 SAGA-ASSOCIATED FACTOR 29 chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG182127|UniProtKB=T1FHT0 T1FHT0 20208379 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG169709|UniProtKB=T1F292 T1F292 20202942 PTHR44927:SF2 FK506-BINDING PROTEIN 15 PEPTIDYLPROLYL ISOMERASE HELRO|EnsemblGenome=HelroG161175|UniProtKB=T1ER69 T1ER69 20199069 PTHR11388:SF157 ORGANIC ANION TRANSPORTER ORGANIC ANION TRANSPORTING POLYPEPTIDE 30B, ISOFORM A transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG165588|UniProtKB=T1EX14 T1EX14 20201114 PTHR12205:SF0 CENTROMERE/KINETOCHORE PROTEIN ZW10 CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG cellular localization#GO:0051641;nuclear division#GO:0000280;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;negative regulation of cell cycle phase transition#GO:1901988;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;cellular component organization or biogenesis#GO:0071840;negative regulation of chromosome segregation#GO:0051985;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;vesicle-mediated transport#GO:0016192;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;negative regulation of sister chromatid segregation#GO:0033046;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;signal transduction#GO:0007165;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of cellular process#GO:0050794;negative regulation of organelle organization#GO:0010639;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;chromosome organization#GO:0051276;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of mitotic sister chromatid separation#GO:2000816;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;cellular component organization#GO:0016043;negative regulation of cell cycle#GO:0045786;Golgi vesicle transport#GO:0048193;regulation of chromosome segregation#GO:0051983;chromosome segregation#GO:0007059;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;mitotic spindle assembly checkpoint signaling#GO:0007094;organelle fission#GO:0048285;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;negative regulation of chromosome organization#GO:2001251;mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle checkpoint signaling#GO:0007093;establishment of localization#GO:0051234;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;regulation of chromosome organization#GO:0033044;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;mitotic sister chromatid segregation#GO:0000070;regulation of mitotic cell cycle#GO:0007346 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;microtubule#GO:0005874;spindle microtubule#GO:0005876;kinetochore#GO:0000776;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;spindle#GO:0005819;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;vesicle tethering complex#GO:0099023;endoplasmic reticulum protein-containing complex#GO:0140534;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG75099|UniProtKB=T1G206 T1G206 20215104 PTHR31655:SF7 PROTEIN FAM78A PROTEIN FAM78B-LIKE HELRO|EnsemblGenome=HelroG188546|UniProtKB=T1FQ39 T1FQ39 20210936 PTHR21532:SF0 PHOSPHODIESTERASE HL CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36 ciliary base#GO:0097546;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG96017|UniProtKB=T1G998 T1G998 20217645 PTHR10454:SF253 CASPASE CASPASE DRICE-RELATED cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;biological regulation#GO:0065007;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;regulation of neuron apoptotic process#GO:0043523;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG81466|UniProtKB=T1G4E6 T1G4E6 20215944 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG65381|UniProtKB=T1FY69 T1FY69 20213767 PTHR10336:SF196 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN PHOSPHOINOSITIDE PHOSPHOLIPASE C lipase activity#GO:0016298;hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;modulation of chemical synaptic transmission#GO:0050804;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;cellular process#GO:0009987;regulation of biological process#GO:0050789 lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HELRO|EnsemblGenome=HelroG182517|UniProtKB=T1FIB1 T1FIB1 20208560 PTHR19302:SF27 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 4 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 microtubule nucleation#GO:0007020;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;cytoplasmic microtubule organization#GO:0031122;reproductive process#GO:0022414;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;spindle assembly#GO:0051225;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG161910|UniProtKB=T1ES14 T1ES14 20199364 PTHR11051:SF8 GLYCOSYL HYDROLASE-RELATED MIP16835P1 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG65176|UniProtKB=T1FY43 T1FY43 20213741 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG128637|UniProtKB=T1EHP5 T1EHP5 20196095 PTHR23430:SF50 HISTONE H2A HISTONE H2A structural molecule activity#GO:0005198 heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185764|UniProtKB=T1FN95 T1FN95 20210293 PTHR11964:SF1 S-ADENOSYLMETHIONINE SYNTHETASE S-ADENOSYLMETHIONINE SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 nucleotidyltransferase#PC00174;transferase#PC00220 S-adenosylmethionine biosynthesis#P02773>S-Adenosyl methionine synthetase#P03143 HELRO|EnsemblGenome=HelroG69639|UniProtKB=T1FZX6 T1FZX6 20214374 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215 monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;metal ion transport#GO:0030001;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG64352|UniProtKB=T1FXT3 T1FXT3 20213631 PTHR24056:SF400 CELL DIVISION PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG98055|UniProtKB=T1G9K3 T1G9K3 20217749 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244 cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG163574|UniProtKB=T1EU83 T1EU83 20200133 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG86007|UniProtKB=T1G658 T1G658 20216555 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185794|UniProtKB=T1FNA7 T1FNA7 20210304 PTHR11735:SF14 TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG75596|UniProtKB=T1G269 T1G269 20215167 PTHR10113:SF10 PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;translation factor activity#GO:0180051 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;protein-containing complex disassembly#GO:0032984;translational termination#GO:0006415;translation#GO:0006412;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 translation release factor#PC00225;translation factor#PC00223 HELRO|EnsemblGenome=HelroG194118|UniProtKB=T1FVQ0 T1FVQ0 20212896 PTHR23172:SF19 AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED J DOMAIN-CONTAINING PROTEIN binding#GO:0005488;clathrin binding#GO:0030276;protein binding#GO:0005515 cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component disassembly#GO:0022411 vesicle#GO:0031982;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG187087|UniProtKB=T1FP67 T1FP67 20210614 PTHR11158:SF29 MSF1/PX19 RELATED PRELI DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013 macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;lipid transport#GO:0006869;organophosphate ester transport#GO:0015748;transport#GO:0006810;lipid localization#GO:0010876;localization#GO:0051179;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG172250|UniProtKB=T1F559 T1F559 20203958 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG167983|UniProtKB=T1F014 T1F014 20202164 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82214|UniProtKB=T1G4P3 T1G4P3 20216041 PTHR10075:SF129 BASIGIN RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG191614|UniProtKB=T1FT46 T1FT46 20211993 PTHR20870:SF0 BARDET-BIEDL SYNDROME 1 PROTEIN BBSOME COMPLEX MEMBER BBS1 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488 protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;non-motile cilium assembly#GO:1905515;localization#GO:0051179;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;BBSome#GO:0034464;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG191072|UniProtKB=T1FSK2 T1FSK2 20211799 PTHR20992:SF9 AT15442P-RELATED AT15442P-RELATED HELRO|EnsemblGenome=HelroG194638|UniProtKB=T1FW95 T1FW95 20213091 PTHR13002:SF1 C3ORF1 PROTEIN-RELATED COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG178482|UniProtKB=T1FD88 T1FD88 20206787 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG170716|UniProtKB=T1F3C6 T1F3C6 20203325 PTHR31872:SF4 TRANSMEMBRANE PROTEIN 179 TRANSMEMBRANE PROTEIN 179 HELRO|EnsemblGenome=HelroG156397|UniProtKB=T1ELV5 T1ELV5 20197555 PTHR22981:SF85 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG163911|UniProtKB=T1EUM0 T1EUM0 20200270 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN LD44267P cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG175786|UniProtKB=T1F9N7 T1F9N7 20205536 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056 nucleus#GO:0005634;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;endoribonuclease#PC00094 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG170169|UniProtKB=T1F2Q7 T1F2Q7 20203106 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG65782|UniProtKB=T1FYC6 T1FYC6 20213824 PTHR31634:SF2 BLOC-1-RELATED COMPLEX SUBUNIT 5 BLOC-1-RELATED COMPLEX SUBUNIT 5 intracellular transport#GO:0046907;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;microtubule-based process#GO:0007017;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;lysosome localization#GO:0032418;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;organelle transport along microtubule#GO:0072384;regulation of microtubule-based process#GO:0032886;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological process#GO:0050789;regulation of microtubule-based movement#GO:0060632;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;side of membrane#GO:0098552;lysosome#GO:0005764;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;cell junction#GO:0030054;lysosomal membrane#GO:0005765;presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;vacuole#GO:0005773;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;vacuolar membrane#GO:0005774;membrane#GO:0016020;vesicle membrane#GO:0012506;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133 HELRO|EnsemblGenome=HelroG107575|UniProtKB=T1EEB4 T1EEB4 20194916 PTHR19855:SF11 WD40 REPEAT PROTEIN 12, 37 RIBOSOME BIOGENESIS PROTEIN WDR12 HOMOLOG HELRO|EnsemblGenome=HelroG166877|UniProtKB=T1EYP3 T1EYP3 20201693 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG174754|UniProtKB=T1F8F8 T1F8F8 20205107 PTHR12864:SF85 RAN BINDING PROTEIN 9-RELATED GLUCOSE-INDUCED DEGRADATION PROTEIN 8 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;catabolic process#GO:0009056;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;positive regulation of canonical Wnt signaling pathway#GO:0090263;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66479|UniProtKB=T1FYL8 T1FYL8 20213916 PTHR16017:SF0 GASTRULATION DEFECTIVE PROTEIN 1-RELATED WD REPEAT-CONTAINING PROTEIN 70 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG157354|UniProtKB=T1EMA1 T1EMA1 20197701 PTHR24072:SF142 RHO FAMILY GTPASE RHOU, ISOFORM B pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515 cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;transport#GO:0006810;actin filament organization#GO:0007015;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;actin filament-based process#GO:0030029;establishment or maintenance of cell polarity#GO:0007163;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG170116|UniProtKB=T1F2N5 T1F2N5 20203084 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192000|UniProtKB=T1FTH9 T1FTH9 20212126 PTHR36498:SF1 TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172 TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172 HELRO|EnsemblGenome=HelroG175474|UniProtKB=T1F9A6 T1F9A6 20205405 PTHR13362:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S33 SMALL RIBOSOMAL SUBUNIT PROTEIN MS33 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177502|UniProtKB=T1FBT4 T1FBT4 20206283 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG188363|UniProtKB=T1FPX3 T1FPX3 20210870 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056 transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005 HELRO|EnsemblGenome=HelroG163861|UniProtKB=T1EUJ7 T1EUJ7 20200247 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG181904|UniProtKB=T1FHG2 T1FHG2 20208261 PTHR45080:SF48 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular component organization#GO:0016043;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;cell body#GO:0044297;neuron projection#GO:0043005 HELRO|EnsemblGenome=HelroG109800|UniProtKB=T1EEW4 T1EEW4 20195116 PTHR10947:SF0 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 PHENYLALANINE--TRNA LIGASE BETA SUBUNIT catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;catalytic complex#GO:1902494 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG145858|UniProtKB=T1EJN4 T1EJN4 20196784 PTHR45787:SF13 LD11652P LD11652P transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG109555|UniProtKB=T1EEU8 T1EEU8 20195100 PTHR23420:SF31 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE-LIKE 1-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824 homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;proteinogenic amino acid metabolic process#GO:0170039;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound metabolic process#GO:0072521;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG74919|UniProtKB=T1G1X8 T1G1X8 20215076 PTHR12220:SF13 50S/60S RIBOSOMAL PROTEIN L16 LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;RNA binding#GO:0003723;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840 ribosomal protein#PC00202 Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005 HELRO|EnsemblGenome=HelroG169268|UniProtKB=T1F1P0 T1F1P0 20202740 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193208|UniProtKB=T1FUR3 T1FUR3 20212559 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG185127|UniProtKB=T1FMF5 T1FMF5 20210004 PTHR45810:SF9 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG141663|UniProtKB=T1EJ38 T1EJ38 20196588 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;positive regulation of organelle organization#GO:0010638;supramolecular fiber organization#GO:0097435;positive regulation of cellular component organization#GO:0051130;actin filament-based process#GO:0030029;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG66944|UniProtKB=T1FYT6 T1FYT6 20213984 PTHR11473:SF15 AROMATIC AMINO ACID HYDROXYLASE TYROSINE 3-MONOOXYGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 synaptic transmission, dopaminergic#GO:0001963;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501;system process#GO:0003008;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;reproductive process#GO:0022414;anterograde trans-synaptic signaling#GO:0098916;nervous system process#GO:0050877;trans-synaptic signaling#GO:0099537;cognition#GO:0050890;multicellular organismal reproductive process#GO:0048609;cell communication#GO:0007154 perikaryon#GO:0043204;intracellular anatomical structure#GO:0005622;axon#GO:0030424;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;neuron projection#GO:0043005;cell body#GO:0044297 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Dopamine receptor mediated signaling pathway#P05912>TH#P05970;Adrenaline and noradrenaline biosynthesis#P00001>TH#P00062 HELRO|EnsemblGenome=HelroG150328|UniProtKB=T1EKF1 T1EKF1 20197051 PTHR22957:SF676 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 2B enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG168373|UniProtKB=T1F0I0 T1F0I0 20202330 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG147987|UniProtKB=T1EK38 T1EK38 20196938 PTHR23235:SF60 KRUEPPEL-LIKE TRANSCRIPTION FACTOR STRIPE, ISOFORM D sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG156140|UniProtKB=T1ELR9 T1ELR9 20197519 PTHR23074:SF19 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A1 ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG148954|UniProtKB=T1EKC2 T1EKC2 20197022 PTHR10037:SF230 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter activity#GO:0005215;voltage-gated sodium channel activity#GO:0005248;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 membrane depolarization#GO:0051899;metal ion transport#GO:0030001;biological regulation#GO:0065007;action potential#GO:0001508;calcium ion import#GO:0070509;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810 plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;neuron projection#GO:0043005;membrane#GO:0016020;membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG159443|UniProtKB=T1EP15 T1EP15 20198315 PTHR11440:SF114 LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED BCDNA.GH02384 metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid metabolic process#GO:0006629 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG152831|UniProtKB=T1EKX5 T1EKX5 20197225 PTHR11256:SF56 BCL-2 RELATED BCL-2 BCL-2 HOMOLOGY REGION 1-3 DOMAIN-CONTAINING PROTEIN channel activity#GO:0015267;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cellular process#GO:0050794;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501 mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG172157|UniProtKB=T1F530 T1F530 20203929 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG173693|UniProtKB=T1F746 T1F746 20204645 PTHR31780:SF10 STRESS RESPONSE PROTEIN NST1-RELATED STRESS RESPONSE PROTEIN NST1 HELRO|EnsemblGenome=HelroG116366|UniProtKB=T1EGE3 T1EGE3 20195645 PTHR22957:SF547 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 16 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG188743|UniProtKB=T1FQB6 T1FQB6 20211013 PTHR23167:SF69 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED FI18193P1 cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin filament#GO:0005884;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG78292|UniProtKB=T1G3A3 T1G3A3 20215551 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;trans-synaptic signaling#GO:0099537;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810 signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG68624|UniProtKB=T1FZH4 T1FZH4 20214222 PTHR22890:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG194789|UniProtKB=T1FWE9 T1FWE9 20213144 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS HOMEOTIC PROTEIN FEMALE STERILE-RELATED chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG178141|UniProtKB=T1FCT9 T1FCT9 20206638 PTHR12425:SF5 SYNEMBRYN CHAPERONE RIC-8 guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG182054|UniProtKB=T1FHN8 T1FHN8 20208337 PTHR19282:SF456 TETRASPANIN FI23944P1-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175050|UniProtKB=T1F8S4 T1F8S4 20205223 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166880|UniProtKB=T1EYP6 T1EYP6 20201696 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182846|UniProtKB=T1FIU8 T1FIU8 20208747 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG181777|UniProtKB=T1FHB3 T1FHB3 20208212 PTHR31109:SF2 PROTEIN FAM207A RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG HELRO|EnsemblGenome=HelroG80629|UniProtKB=T1G430 T1G430 20215828 PTHR46365:SF1 COPPER TRANSPORT PROTEIN ATOX1 COPPER TRANSPORT PROTEIN ATOX1 molecular carrier activity#GO:0140104 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG176655|UniProtKB=T1FAR7 T1FAR7 20205916 PTHR13865:SF28 TIGHT JUNCTION PROTEIN POLYCHAETOID, ISOFORM O protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell-cell junction organization#GO:0045216;cell adhesion#GO:0007155;protein localization to cell junction#GO:1902414;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;cellular process#GO:0009987;macromolecule localization#GO:0033036;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cell junction organization#GO:0034330 cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;apical junction complex#GO:0043296;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161 cell junction protein#PC00070;tight junction#PC00214 HELRO|EnsemblGenome=HelroG63079|UniProtKB=T1FXA8 T1FXA8 20213456 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG161682|UniProtKB=T1ERS4 T1ERS4 20199274 PTHR22950:SF646 AMINO ACID TRANSPORTER SOLUTE CARRIER FAMILY 38 MEMBER 10 amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;L-amino acid transmembrane transporter activity#GO:0015179 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;amino acid transport#GO:0006865;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG103978|UniProtKB=T1EDJ0 T1EDJ0 20194642 PTHR44366:SF1 UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;biosynthetic process#GO:0009058 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171259|UniProtKB=T1F401 T1F401 20203550 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155730|UniProtKB=T1ELL6 T1ELL6 20197466 PTHR13359:SF2 39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML40 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG87531|UniProtKB=T1G6R6 T1G6R6 20216763 PTHR12375:SF47 RNA-BINDING PROTEIN LUC7-RELATED LUC7-LIKE PROTEIN 3 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2-type prespliceosome#GO:0071004;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG191869|UniProtKB=T1FTD4 T1FTD4 20212081 PTHR13817:SF151 TITIN BENT, ISOFORM F-RELATED structural molecule activity#GO:0005198 actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;anatomical structure morphogenesis#GO:0009653;myofibril assembly#GO:0030239;muscle cell development#GO:0055001;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;animal gross anatomical part developmental process#GO:0160108;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;contractile muscle fiber#GO:0043292;A band#GO:0031672;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;membraneless organelle#GO:0043228;sarcomere#GO:0030017;intracellular organelle#GO:0043229;M band#GO:0031430 structural protein#PC00211 HELRO|EnsemblGenome=HelroG178730|UniProtKB=T1FDN0 T1FDN0 20206929 PTHR18849:SF8 LEUCINE RICH REPEAT PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61 HELRO|EnsemblGenome=HelroG172415|UniProtKB=T1F5A6 T1F5A6 20204005 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG117263|UniProtKB=T1EGL5 T1EGL5 20195715 PTHR11208:SF131 RNA-BINDING PROTEIN RELATED PROTEIN QUAKING-A RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG189913|UniProtKB=T1FRH3 T1FRH3 20211420 PTHR11584:SF369 SERINE/THREONINE PROTEIN KINASE APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773 p38MAPK cascade#GO:0038066;response to stimulus#GO:0050896;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>MEKK1-5#P00553;FGF signaling pathway#P00021>MEKK1-5#P00634 HELRO|EnsemblGenome=HelroG84338|UniProtKB=T1G5H6 T1G5H6 20216323 PTHR23123:SF38 PHD/F-BOX CONTAINING PROTEIN JMJC DOMAIN-CONTAINING PROTEIN-RELATED catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452 cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG191922|UniProtKB=T1FTF1 T1FTF1 20212098 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG72038|UniProtKB=T1G0U4 T1G0U4 20214692 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888 regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG183471|UniProtKB=T1FJQ6 T1FJQ6 20209055 PTHR13145:SF0 SSM4 PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MARCHF6 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG160514|UniProtKB=T1EQC5 T1EQC5 20198775 PTHR15683:SF8 SCAFFOLD ATTACHMENT FACTOR B-RELATED SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG175630|UniProtKB=T1F9G0 T1F9G0 20205459 PTHR12021:SF26 THYMOSIN BETA THYMOSIN BETA HOMOLOGUE binding#GO:0005488;molecular sequestering activity#GO:0140313;actin monomer binding#GO:0003785;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein sequestering activity#GO:0140311;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell migration#GO:0030334;regulation of biological process#GO:0050789 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG180355|UniProtKB=T1FFT3 T1FFT3 20207682 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG184640|UniProtKB=T1FLN2 T1FLN2 20209731 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76935|UniProtKB=T1G2R7 T1G2R7 20215365 PTHR43918:SF17 ACETYLCHOLINESTERASE ACETYLCHOLINESTERASE 1 catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 metabolic process#GO:0008152;cellular process#GO:0009987;catabolic process#GO:0009056 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 esterase#PC00097 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HELRO|EnsemblGenome=HelroG78097|UniProtKB=T1G377 T1G377 20215525 PTHR21258:SF61 DOCKING PROTEIN RELATED DOCKING PROTEIN 5-LIKE ISOFORM X1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194200|UniProtKB=T1FVS7 T1FVS7 20212923 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173504|UniProtKB=T1F6W7 T1F6W7 20204566 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG165623|UniProtKB=T1EX33 T1EX33 20201133 PTHR37001:SF5 PHOSPHORYN, PUTATIVE-RELATED-RELATED RIIA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156877|UniProtKB=T1EM24 T1EM24 20197624 PTHR48493:SF1 UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1 UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1 phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG186172|UniProtKB=T1FNR7 T1FNR7 20210464 PTHR10218:SF227 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA I SUBUNIT GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991 G-protein#PC00020;heterotrimeric G-protein#PC00117 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Opioid proenkephalin pathway#P05915>G-protein#P05994;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Opioid prodynorphin pathway#P05916>G-protein#P06002;PI3 kinase pathway#P00048>Galpha#P01199;Enkephalin release#P05913>G-Protein (i)#P05974 HELRO|EnsemblGenome=HelroG93032|UniProtKB=T1G8R4 T1G8R4 20217461 PTHR33269:SF17 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG74746|UniProtKB=T1G1V2 T1G1V2 20215050 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG81239|UniProtKB=T1G4C0 T1G4C0 20215918 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG159915|UniProtKB=T1EPJ8 T1EPJ8 20198498 PTHR24249:SF425 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG88726|UniProtKB=T1G759 T1G759 20216906 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG176024|UniProtKB=T1FA14 T1FA14 20205663 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185763|UniProtKB=T1FN94 T1FN94 20210292 PTHR23001:SF7 EUKARYOTIC TRANSLATION INITIATION FACTOR EUKARYOTIC TRANSLATION INITIATION FACTOR 5 enzyme regulator activity#GO:0030234;protein binding#GO:0005515;binding#GO:0005488;translation initiation factor activity#GO:0003743;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;translation initiation factor binding#GO:0031369;translation factor activity#GO:0180051 translation#GO:0006412;translational initiation#GO:0006413;cytoplasmic translational initiation#GO:0002183;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG95367|UniProtKB=T1G954 T1G954 20217601 PTHR11675:SF133 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG176179|UniProtKB=T1FA93 T1FA93 20205742 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190937|UniProtKB=T1FSF8 T1FSF8 20211755 PTHR46143:SF1 CALPAIN-7 CALPAIN-7 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG115447|UniProtKB=T1EG82 T1EG82 20195584 PTHR22968:SF24 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Angiogenesis#P00005>PKC#P00219;VEGF signaling pathway#P00056>PKC#P01425;EGF receptor signaling pathway#P00018>PKC#P00565 HELRO|EnsemblGenome=HelroG171406|UniProtKB=T1F486 T1F486 20203635 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133 HELRO|EnsemblGenome=HelroG185916|UniProtKB=T1FNF7 T1FNF7 20210354 PTHR10621:SF0 UV EXCISION REPAIR PROTEIN RAD23 UV EXCISION REPAIR PROTEIN RAD23 modification-dependent protein binding#GO:0140030;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;ubiquitin binding#GO:0043130;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG193289|UniProtKB=T1FUU2 T1FUU2 20212588 PTHR22923:SF124 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161499|UniProtKB=T1ERK0 T1ERK0 20199200 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG127062|UniProtKB=T1EHC7 T1EHC7 20195977 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN 84-LIKE DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG170242|UniProtKB=T1F2T6 T1F2T6 20203135 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194400|UniProtKB=T1FW08 T1FW08 20213004 PTHR13060:SF0 SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2 PROTEIN ECDYSONELESS HOMOLOG transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG171997|UniProtKB=T1F4X5 T1F4X5 20203874 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG180844|UniProtKB=T1FGB9 T1FGB9 20207868 PTHR48027:SF18 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 positive regulation of mRNA metabolic process#GO:1903313;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG66521|UniProtKB=T1FYM2 T1FYM2 20213920 PTHR11771:SF180 LIPOXYGENASE ARACHIDONATE 5-LIPOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid modification#GO:0030258;lipid oxidation#GO:0034440 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG84695|UniProtKB=T1G5M3 T1G5M3 20216370 PTHR10484:SF162 HISTONE H4 HISTONE H4-LIKE PROTEIN TYPE G structural molecule activity#GO:0005198 protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG111318|UniProtKB=T1EFA3 T1EFA3 20195255 PTHR47633:SF4 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173528|UniProtKB=T1F6Y1 T1F6Y1 20204580 PTHR43010:SF1 UNIVERSAL STRESS PROTEIN SLR1230 USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194459|UniProtKB=T1FW28 T1FW28 20213024 PTHR46117:SF3 FI24210P1 FI24210P1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG195101|UniProtKB=T1FWR1 T1FWR1 20213256 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG166153|UniProtKB=T1EXU7 T1EXU7 20201397 PTHR46004:SF3 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HELRO|EnsemblGenome=HelroG173601|UniProtKB=T1F707 T1F707 20204606 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG149824|UniProtKB=T1EKD7 T1EKD7 20197037 PTHR11654:SF509 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG191746|UniProtKB=T1FT94 T1FT94 20212041 PTHR11347:SF179 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC PHOSPHODIESTERASE PDE-3-RELATED cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG167607|UniProtKB=T1EZJ7 T1EZJ7 20201997 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG185412|UniProtKB=T1FMS3 T1FMS3 20210122 PTHR11751:SF29 ALANINE AMINOTRANSFERASE ALANINE TRANSAMINASE transferase#PC00220;transaminase#PC00216 HELRO|EnsemblGenome=HelroG171927|UniProtKB=T1F4V3 T1F4V3 20203852 PTHR34495:SF4 UNC-51-LIKE AUTOPHAGY-ACTIVATING KINASE 1A NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG141779|UniProtKB=T1EJ42 T1EJ42 20196592 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;cell fate specification#GO:0001708;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;axonogenesis#GO:0007409;neuron development#GO:0048666;cell fate commitment#GO:0045165;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;plasma membrane bounded cell projection organization#GO:0120036;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG64443|UniProtKB=T1FXV0 T1FXV0 20213648 PTHR10110:SF201 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;import across plasma membrane#GO:0098739;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813 recycling endosome#GO:0055037;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG160421|UniProtKB=T1EQ82 T1EQ82 20198732 PTHR11839:SF15 UDP/ADP-SUGAR PYROPHOSPHATASE URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 metabolite interconversion enzyme#PC00262;pyrophosphatase#PC00196 HELRO|EnsemblGenome=HelroG92122|UniProtKB=T1G8C2 T1G8C2 20217319 PTHR46212:SF11 PEFLIN PEFLIN HELRO|EnsemblGenome=HelroG172694|UniProtKB=T1F5T0 T1F5T0 20204179 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG180797|UniProtKB=T1FGA4 T1FGA4 20207853 PTHR24235:SF29 NEUROPEPTIDE Y RECEPTOR GH23382P signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG158828|UniProtKB=T1ENB2 T1ENB2 20198062 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG160729|UniProtKB=T1EQN2 T1EQN2 20198882 PTHR14344:SF3 WD REPEAT PROTEIN TRNA (34-2'-O)-METHYLTRANSFERASE REGULATOR WDR6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG98115|UniProtKB=T1G9K8 T1G9K8 20217754 PTHR21141:SF5 60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN P2 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG167566|UniProtKB=T1EZH9 T1EZH9 20201979 PTHR13339:SF2 COP9 SIGNALOSOME COMPLEX SUBUNIT 8 COP9 SIGNALOSOME COMPLEX SUBUNIT 8 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG153379|UniProtKB=T1EL60 T1EL60 20197310 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG105390|UniProtKB=T1EDU3 T1EDU3 20194745 PTHR12537:SF195 RNA BINDING PROTEIN PUMILIO-RELATED MATERNAL PROTEIN PUMILIO RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84353|UniProtKB=T1G5H8 T1G5H8 20216325 PTHR23105:SF101 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN UL1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161909|UniProtKB=T1ES13 T1ES13 20199363 PTHR45682:SF5 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG108184|UniProtKB=T1EEG5 T1EEG5 20194967 PTHR12276:SF126 EPSIN/ENT-RELATED CLATHRIN INTERACTOR 1 lipid binding#GO:0008289;protein binding#GO:0005515;phospholipid binding#GO:0005543;binding#GO:0005488;clathrin binding#GO:0030276 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular organelle#GO:0043229;endosome#GO:0005768;plasma membrane#GO:0005886;vesicle coat#GO:0030120;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG64314|UniProtKB=T1FXS7 T1FXS7 20213625 PTHR11960:SF18 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B translation initiation factor activity#GO:0003743;RNA binding#GO:0003723;translation factor activity#GO:0180051;nucleic acid binding#GO:0003676;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG162169|UniProtKB=T1ESB4 T1ESB4 20199464 PTHR11913:SF122 COFILIN-RELATED COFILIN_ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 actin cytoskeleton organization#GO:0030036;protein depolymerization#GO:0051261;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;actin filament depolymerization#GO:0030042;cellular component disassembly#GO:0022411;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG185138|UniProtKB=T1FMG0 T1FMG0 20210009 PTHR46115:SF1 THIOREDOXIN-LIKE PROTEIN 1 THIOREDOXIN-LIKE PROTEIN 1 disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 Oxidative stress response#P00046>TRX#P01122 HELRO|EnsemblGenome=HelroG170827|UniProtKB=T1F3H2 T1F3H2 20203371 PTHR35711:SF1 EXPRESSED PROTEIN ECTODERMAL, ISOFORM F HELRO|EnsemblGenome=HelroG98767|UniProtKB=T1G9P6 T1G9P6 20217792 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG63543|UniProtKB=T1FXH1 T1FXH1 20213519 PTHR13088:SF3 FAS APOPTOTIC INHIBITORY MOLECULE FAIM FAS APOPTOTIC INHIBITORY MOLECULE 1 negative regulation of cell communication#GO:0010648;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;negative regulation of programmed cell death#GO:0043069 HELRO|EnsemblGenome=HelroG185597|UniProtKB=T1FN06 T1FN06 20210205 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CELL DIVISION CYCLE 50, ISOFORM A enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;phospholipid transport#GO:0015914;lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG109933|UniProtKB=T1EEX5 T1EEX5 20195127 PTHR48036:SF6 SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED RNA-BINDING MOTIF PROTEIN 39A-RELATED binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG105422|UniProtKB=T1EDU7 T1EDU7 20194749 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG170736|UniProtKB=T1F3D3 T1F3D3 20203332 PTHR23121:SF10 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 1 transporter#PC00227 HELRO|EnsemblGenome=HelroG95925|UniProtKB=T1G989 T1G989 20217636 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG182432|UniProtKB=T1FI67 T1FI67 20208516 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG161131|UniProtKB=T1ER45 T1ER45 20199045 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98742|UniProtKB=T1G9P5 T1G9P5 20217791 PTHR19134:SF570 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 animal gross anatomical part developmental process#GO:0160108;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;developmental process#GO:0032502;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171460|UniProtKB=T1F4B2 T1F4B2 20203661 PTHR46670:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180025|UniProtKB=T1FFD0 T1FFD0 20207529 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116477|UniProtKB=T1EGF3 T1EGF3 20195655 PTHR10414:SF78 ETHANOLAMINEPHOSPHOTRANSFERASE DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE transferase#PC00220 HELRO|EnsemblGenome=HelroG194759|UniProtKB=T1FWD7 T1FWD7 20213132 PTHR11969:SF99 MAX DIMERIZATION, MAD MAX-BINDING PROTEIN MNT sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG165521|UniProtKB=T1EWY8 T1EWY8 20201088 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG157035|UniProtKB=T1EM50 T1EM50 20197650 PTHR12821:SF0 BYSTIN BYSTIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515 gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG168571|UniProtKB=T1F0R0 T1F0R0 20202410 PTHR22968:SF24 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Angiogenesis#P00005>PKC#P00219;VEGF signaling pathway#P00056>PKC#P01425;EGF receptor signaling pathway#P00018>PKC#P00565 HELRO|EnsemblGenome=HelroG171477|UniProtKB=T1F4C2 T1F4C2 20203671 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158709|UniProtKB=T1EN54 T1EN54 20198004 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185887|UniProtKB=T1FNE5 T1FNE5 20210342 PTHR11830:SF0 40S RIBOSOMAL PROTEIN S3A SMALL RIBOSOMAL SUBUNIT PROTEIN ES1 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG183148|UniProtKB=T1FJ76 T1FJ76 20208875 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG161501|UniProtKB=T1ERK2 T1ERK2 20199202 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;voltage-gated monoatomic cation channel activity#GO:0022843;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG169994|UniProtKB=T1F2I2 T1F2I2 20203032 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63866|UniProtKB=T1FXL3 T1FXL3 20213561 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HELRO|EnsemblGenome=HelroG125254|UniProtKB=T1EH52 T1EH52 20195902 PTHR12999:SF26 ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 carbohydrate derivative binding#GO:0097367;binding#GO:0005488;lipopolysaccharide binding#GO:0001530;lipid binding#GO:0008289 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG62958|UniProtKB=T1FX85 T1FX85 20213433 PTHR37001:SF9 PHOSPHORYN, PUTATIVE-RELATED-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG99061|UniProtKB=T1G9Q7 T1G9Q7 20217803 PTHR12498:SF0 N-TERMINAL ASPARAGINE AMIDOHYDROLASE PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77178|UniProtKB=T1G2U1 T1G2U1 20215389 PTHR14256:SF3 NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT CYTOCHROME C OXIDASE ASSOCIATED SUBUNIT FA4L3 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG191784|UniProtKB=T1FTB5 T1FTB5 20212062 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 immune system process#GO:0002376;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG145228|UniProtKB=T1EJJ4 T1EJJ4 20196744 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157737|UniProtKB=T1EMF0 T1EMF0 20197750 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;export from cell#GO:0140352 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG177690|UniProtKB=T1FC32 T1FC32 20206381 PTHR10740:SF14 TRANSFORMING GROWTH FACTOR ALPHA EGF-LIKE DOMAIN-CONTAINING PROTEIN enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of organelle organization#GO:0010638;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cellular component organization#GO:0051130;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;positive regulation of cell population proliferation#GO:0008284;regulation of mitotic nuclear division#GO:0007088;cell surface receptor signaling pathway#GO:0007166;positive regulation of mitotic nuclear division#GO:0045840;positive regulation of cell cycle#GO:0045787;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;epidermal growth factor receptor signaling pathway#GO:0007173;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 growth factor#PC00112 HELRO|EnsemblGenome=HelroG63593|UniProtKB=T1FXH9 T1FXH9 20213527 PTHR23147:SF189 SERINE/ARGININE RICH SPLICING FACTOR SERINE AND ARGININE-RICH-SPLICING FACTOR 3A-RELATED intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG103064|UniProtKB=T1EDE0 T1EDE0 20194592 PTHR11203:SF37 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER INTEGRATOR COMPLEX SUBUNIT 11 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG91552|UniProtKB=T1G853 T1G853 20217250 PTHR19858:SF0 WD40 REPEAT PROTEIN PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;ribosomal small subunit assembly#GO:0000028;macromolecule metabolic process#GO:0043170;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG185316|UniProtKB=T1FMN4 T1FMN4 20210083 PTHR11932:SF177 CULLIN CULLIN-4A ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;protein complex scaffold activity#GO:0140378;enzyme binding#GO:0019899;protein binding#GO:0005515;structural molecule activity#GO:0005198;ubiquitin protein ligase binding#GO:0031625 proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA damage response#GO:0006974;catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG161967|UniProtKB=T1ES36 T1ES36 20199386 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG92027|UniProtKB=T1G8B5 T1G8B5 20217312 PTHR10336:SF36 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;metabolic process#GO:0008152;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;signal transduction#GO:0007165;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;transport#GO:0006810;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143;hydrolase#PC00121 Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Metabotropic glutamate receptor group I pathway#P00041>PLC#P01053;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Endothelin signaling pathway#P00019>PLCbeta#P00591;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PLC#P01068;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Wnt signaling pathway#P00057>Phospholipase C#P01443;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874 HELRO|EnsemblGenome=HelroG173420|UniProtKB=T1F6S9 T1F6S9 20204528 PTHR43601:SF39 THIOREDOXIN, MITOCHONDRIAL THIOREDOXIN, MITOCHONDRIAL homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG113546|UniProtKB=T1EFT3 T1EFT3 20195435 PTHR15949:SF3 TESTIS-EXPRESSED PROTEIN 264 TESTIS-EXPRESSED PROTEIN 264 response to stimulus#GO:0050896;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;macroautophagy#GO:0016236;nucleobase-containing compound metabolic process#GO:0006139;reticulophagy#GO:0061709;response to stress#GO:0006950;cellular process#GO:0009987;autophagy#GO:0006914;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974 autophagosome#GO:0005776;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;replication fork#GO:0005657;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;membraneless organelle#GO:0043228;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;nucleus#GO:0005634;endomembrane system#GO:0012505;vacuole#GO:0005773;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG76709|UniProtKB=T1G2N0 T1G2N0 20215328 PTHR43173:SF28 ABC1 FAMILY PROTEIN AARF DOMAIN CONTAINING KINASE 5 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG85485|UniProtKB=T1G5X8 T1G5X8 20216475 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185992|UniProtKB=T1FNJ0 T1FNJ0 20210387 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;embryonic organ development#GO:0048568;positive regulation of RNA metabolic process#GO:0051254;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;nervous system development#GO:0007399;embryo development#GO:0009790;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG108161|UniProtKB=T1EEG1 T1EEG1 20194963 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A8-LIKE oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG182861|UniProtKB=T1FIV9 T1FIV9 20208758 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;regulation of establishment or maintenance of cell polarity#GO:0032878;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;localization#GO:0051179 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG170589|UniProtKB=T1F377 T1F377 20203276 PTHR46169:SF15 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG159488|UniProtKB=T1EP33 T1EP33 20198333 PTHR47027:SF32 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187911|UniProtKB=T1FPG8 T1FPG8 20210715 PTHR22809:SF11 METHYLTRANSFERASE-RELATED TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2 catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG181039|UniProtKB=T1FGJ8 T1FGJ8 20207947 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG180094|UniProtKB=T1FFG6 T1FFG6 20207565 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG172102|UniProtKB=T1F511 T1F511 20203910 PTHR21676:SF8 PROTEIN STUM PROTEIN STUM response to stimulus#GO:0050896;taxis#GO:0042330;multicellular organismal process#GO:0032501;locomotion#GO:0040011;sensory perception#GO:0007600;neuromuscular process#GO:0050905;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877;response to external stimulus#GO:0009605;system process#GO:0003008 neuron projection#GO:0043005;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG167144|UniProtKB=T1EZ26 T1EZ26 20201826 PTHR35261:SF3 ORGANELLAR PROTEIN, PUTATIVE-RELATED-RELATED VACUOLAR IMPORT AND DEGRADATION PROTEIN 22 HELRO|EnsemblGenome=HelroG155003|UniProtKB=T1ELG9 T1ELG9 20197419 PTHR12701:SF20 BCR-ASSOCIATED PROTEIN, BAP ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN protein carrier activity#GO:0140597;ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104 transport#GO:0006810;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;intracellular protein localization#GO:0008104;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;response to endoplasmic reticulum stress#GO:0034976;protein metabolic process#GO:0019538;localization#GO:0051179;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;positive regulation of protein metabolic process#GO:0051247;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;positive regulation of metabolic process#GO:0009893;protein transport#GO:0015031;regulation of biological process#GO:0050789;response to stimulus#GO:0050896 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG174963|UniProtKB=T1F8N5 T1F8N5 20205184 PTHR19325:SF537 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING FURROWED, ISOFORM A complement component#PC00078;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG164073|UniProtKB=T1EUV8 T1EUV8 20200358 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188158|UniProtKB=T1FPQ1 T1FPQ1 20210798 PTHR46659:SF1 SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1 SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 1 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;phosphatase binding#GO:0019902;phosphatase inhibitor activity#GO:0019212;protein phosphatase binding#GO:0019903;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857 regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of apoptotic process#GO:0043065;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;positive regulation of signaling#GO:0023056 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG186121|UniProtKB=T1FNP4 T1FNP4 20210441 PTHR14324:SF3 CONDENSIN-2 COMPLEX SUBUNIT H2 CONDENSIN-2 COMPLEX SUBUNIT H2 binding#GO:0005488;chromatin binding#GO:0003682 chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;chromosome separation#GO:0051304;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;chromosome condensation#GO:0030261;organelle fission#GO:0048285;sexual reproduction#GO:0019953;nuclear division#GO:0000280;reproductive process#GO:0022414;mitotic sister chromatid separation#GO:0051306;mitotic cell cycle#GO:0000278;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cell cycle#GO:0007049 intracellular organelle#GO:0043229;condensin complex#GO:0000796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG79991|UniProtKB=T1G3W1 T1G3W1 20215759 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG161126|UniProtKB=T1ER43 T1ER43 20199043 PTHR10219:SF25 GLYCOLIPID TRANSFER PROTEIN-RELATED RH52220P phospholipid binding#GO:0005543;transporter activity#GO:0005215;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013;lipid binding#GO:0008289 cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;membrane organization#GO:0061024;ceramide transport#GO:0035627;lipid transport#GO:0006869;transport#GO:0006810;lipid localization#GO:0010876;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009 cytosol#GO:0005829;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG188674|UniProtKB=T1FQ85 T1FQ85 20210982 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG116695|UniProtKB=T1EGH0 T1EGH0 20195672 PTHR45623:SF62 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED KISMET, ISOFORM C DNA binding#GO:0003677;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;histone binding#GO:0042393;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG186448|UniProtKB=T1FNZ7 T1FNZ7 20210544 PTHR45893:SF3 POLYCOMB GROUP RING FINGER PROTEIN POLYCOMB GROUP RING FINGER PROTEIN 3 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;PcG protein complex#GO:0031519 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG81129|UniProtKB=T1G498 T1G498 20215896 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG154931|UniProtKB=T1ELG4 T1ELG4 20197414 PTHR43319:SF3 BETA-LACTAMASE-RELATED BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 2 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG186951|UniProtKB=T1FP47 T1FP47 20210594 PTHR12114:SF4 PARVIN GH23568P protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041;actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG177878|UniProtKB=T1FCE7 T1FCE7 20206496 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG192515|UniProtKB=T1FU16 T1FU16 20212312 PTHR22168:SF3 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG85430|UniProtKB=T1G5X0 T1G5X0 20216467 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG184264|UniProtKB=T1FKV5 T1FKV5 20209454 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169063|UniProtKB=T1F1C7 T1F1C7 20202627 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG173085|UniProtKB=T1F6B5 T1F6B5 20204364 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG114561|UniProtKB=T1EG30 T1EG30 20195532 PTHR19308:SF53 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN CERAMIDE TRANSFER PROTEIN transport#GO:0006810;intracellular transport#GO:0046907;lipid localization#GO:0010876;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;ceramide transport#GO:0035627;lipid transport#GO:0006869 HELRO|EnsemblGenome=HelroG68656|UniProtKB=T1FZH7 T1FZH7 20214225 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG189781|UniProtKB=T1FRD4 T1FRD4 20211381 PTHR15495:SF7 NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED GPI INOSITOL-DEACYLASE deacylase activity#GO:0160215;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG167527|UniProtKB=T1EZG4 T1EZG4 20201964 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG177897|UniProtKB=T1FCF9 T1FCF9 20206508 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE FI04477P-RELATED phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;lipid modification#GO:0030258;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phospholipid dephosphorylation#GO:0046839;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;dephosphorylation#GO:0016311;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG103011|UniProtKB=T1EDD7 T1EDD7 20194589 PTHR19972:SF16 CALBINDIN CALBINDIN-32 metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 terminal bouton#GO:0043195;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;dendritic tree#GO:0097447;axon#GO:0030424;intracellular organelle#GO:0043229;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;presynapse#GO:0098793;neuron projection#GO:0043005;cytosol#GO:0005829;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;axon terminus#GO:0043679;cell junction#GO:0030054 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG75866|UniProtKB=T1G2B6 T1G2B6 20215214 PTHR23048:SF33 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN ALKALI contractile muscle fiber#GO:0043292;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG175340|UniProtKB=T1F961 T1F961 20205360 PTHR45929:SF3 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular localization#GO:0051641;protein transport#GO:0015031;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein localization to organelle#GO:0033365;catabolic process#GO:0009056 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle#GO:0031982;intracellular vesicle#GO:0097708 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG102708|UniProtKB=T1EDB1 T1EDB1 20194563 PTHR46961:SF17 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG91813|UniProtKB=T1G895 T1G895 20217292 PTHR46167:SF1 N-LYSINE METHYLTRANSFERASE KMT5A N-LYSINE METHYLTRANSFERASE KMT5A lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;chromosome organization#GO:0051276;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63800|UniProtKB=T1FXK5 T1FXK5 20213553 PTHR24393:SF183 ZINC FINGER PROTEIN LD28458P-RELATED DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG90115|UniProtKB=T1G7L2 T1G7L2 20217059 PTHR17605:SF0 RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN RIBOSOME BIOGENESIS PROTEIN BOP1 binding#GO:0005488;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;RNA binding#GO:0003723 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;preribosome, large subunit precursor#GO:0030687;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG160686|UniProtKB=T1EQL5 T1EQL5 20198865 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 response to stimulus#GO:0050896;response to stress#GO:0006950;response to nutrient levels#GO:0031667;response to starvation#GO:0042594 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG193602|UniProtKB=T1FV60 T1FV60 20212706 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG179547|UniProtKB=T1FEV1 T1FEV1 20207350 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180349|UniProtKB=T1FFS8 T1FFS8 20207677 PTHR46670:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71572|UniProtKB=T1G0N6 T1G0N6 20214634 PTHR32100:SF81 OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC DELTA(12) FATTY ACID DESATURASE FAT-2 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;unsaturated fatty acid biosynthetic process#GO:0006636;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436 HELRO|EnsemblGenome=HelroG157732|UniProtKB=T1EME8 T1EME8 20197748 PTHR24346:SF30 MAP/MICROTUBULE AFFINITY-REGULATING KINASE BR SERINE_THREONINE KINASE 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188057|UniProtKB=T1FPL1 T1FPL1 20210758 PTHR12053:SF4 PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED CARBOXYPEPTIDASE Q peptidase activity#GO:0008233;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG67268|UniProtKB=T1FYZ1 T1FYZ1 20214039 PTHR24418:SF474 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG170266|UniProtKB=T1F2U9 T1F2U9 20203148 PTHR10590:SF24 SODIUM/NUCLEOSIDE COTRANSPORTER CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1-RELATED carbohydrate derivative transmembrane transporter activity#GO:1901505;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;nucleobase-containing compound transmembrane transporter activity#GO:0015932;symporter activity#GO:0015293;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;nucleoside transmembrane transporter activity#GO:0005337;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nucleobase-containing compound transport#GO:0015931 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG167830|UniProtKB=T1EZU7 T1EZU7 20202097 PTHR47013:SF1 SPLICING FACTOR, ARGININE/SERINE-RICH 19 SPLICING FACTOR, ARGININE_SERINE-RICH 19 protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185472|UniProtKB=T1FMV0 T1FMV0 20210149 PTHR11106:SF72 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2 HELRO|EnsemblGenome=HelroG87810|UniProtKB=T1G6V7 T1G6V7 20216804 PTHR45695:SF42 LEUCOKININ RECEPTOR-RELATED GALANIN-LIKE G PROTEIN-COUPLED RECEPTOR NPR-9 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG85865|UniProtKB=T1G636 T1G636 20216533 PTHR11819:SF150 SOLUTE CARRIER FAMILY 5 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M-RELATED solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG160604|UniProtKB=T1EQH3 T1EQH3 20198823 PTHR45628:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1 channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;calcium ion import#GO:0070509;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 voltage-gated ion channel#PC00241 5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096 HELRO|EnsemblGenome=HelroG172804|UniProtKB=T1F5Y5 T1F5Y5 20204234 PTHR10484:SF0 HISTONE H4 HISTONE H4 TYPE VIII structural molecule activity#GO:0005198 chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG142748|UniProtKB=T1EJ73 T1EJ73 20196623 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG71181|UniProtKB=T1G0H6 T1G0H6 20214574 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG97828|UniProtKB=T1G9J2 T1G9J2 PTHR37412:SF2 C2 DOMAIN-CONTAINING PROTEIN 5 C2 DOMAIN-CONTAINING PROTEIN 5 phospholipid binding#GO:0005543;metal ion binding#GO:0046872;cation binding#GO:0043169;lipid binding#GO:0008289;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 biological regulation#GO:0065007;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;regulation of cellular process#GO:0050794;protein localization to plasma membrane#GO:0072659;regulation of transmembrane transport#GO:0034762;localization#GO:0051179;regulation of establishment of protein localization#GO:0070201;localization within membrane#GO:0051668;positive regulation of transport#GO:0051050;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;intracellular protein transmembrane transport#GO:0065002;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of vesicle fusion#GO:0031340;protein localization to cell periphery#GO:1990778;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;regulation of cellular component organization#GO:0051128;protein localization to membrane#GO:0072657;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular localization#GO:0051641;transmembrane transport#GO:0055085;positive regulation of organelle organization#GO:0010638;regulation of protein localization#GO:0032880;protein transport#GO:0015031;positive regulation of cellular component organization#GO:0051130 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG158594|UniProtKB=T1EMZ7 T1EMZ7 20197947 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174143|UniProtKB=T1F7P3 T1F7P3 20204842 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105809|UniProtKB=T1EDX7 T1EDX7 20194779 PTHR20961:SF167 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG188273|UniProtKB=T1FPT7 T1FPT7 20210834 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;organelle organization#GO:0006996;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191525|UniProtKB=T1FT22 T1FT22 20211969 PTHR12552:SF1 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN GRAF enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG113590|UniProtKB=T1EFU1 T1EFU1 20195443 PTHR10762:SF1 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1 cellular process#GO:0009987;metabolic process#GO:0008152;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 HELRO|EnsemblGenome=HelroG96497|UniProtKB=T1G9C6 T1G9C6 20217673 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;sarcoplasmic reticulum#GO:0016529;endomembrane system#GO:0012505;sarcoplasmic reticulum membrane#GO:0033017;cytoplasm#GO:0005737 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG97190|UniProtKB=T1G9F8 T1G9F8 20217705 PTHR23253:SF78 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED RNA binding#GO:0003723;translation initiation factor activity#GO:0003743;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;translation factor activity#GO:0180051 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG82389|UniProtKB=T1G4R7 T1G4R7 20216065 PTHR24356:SF414 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of cell cycle#GO:0051726;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG175331|UniProtKB=T1F954 T1F954 20205353 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189589|UniProtKB=T1FR64 T1FR64 20211311 PTHR11339:SF416 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED HEMOLECTIN, ISOFORM A structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG179728|UniProtKB=T1FF30 T1FF30 20207429 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;proton channel activity#GO:0015252;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG185982|UniProtKB=T1FNI6 T1FNI6 20210383 PTHR11141:SF0 PROTEIN TRANSPORT PROTEIN SEC23 PROTEIN TRANSPORT PROTEIN SEC23 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114;cellular component organization#GO:0016043 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG135232|UniProtKB=T1EI77 T1EI77 20196277 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG76393|UniProtKB=T1G2J5 T1G2J5 20215293 PTHR23084:SF263 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED MORN REPEAT-CONTAINING PROTEIN 1 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG166029|UniProtKB=T1EXM1 T1EXM1 20201321 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184109|UniProtKB=T1FKL5 T1FKL5 20209364 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG158991|UniProtKB=T1ENG6 T1ENG6 20198116 PTHR11481:SF60 IMMUNOGLOBULIN FC RECEPTOR IG-LIKE DOMAIN-CONTAINING PROTEIN cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG86659|UniProtKB=T1G6F0 T1G6F0 20216647 PTHR10887:SF419 DNA2/NAM7 HELICASE FAMILY RNA HELICASE MOV10L1 ISOFORM X1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytosol#GO:0005829 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG123852|UniProtKB=T1EGZ3 T1EGZ3 20195843 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG71629|UniProtKB=T1G0P4 T1G0P4 20214642 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;transport#GO:0006810 signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG188615|UniProtKB=T1FQ67 T1FQ67 20210964 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MULTIDRUG RESISTANCE PROTEIN HOMOLOG 49-RELATED active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG71397|UniProtKB=T1G0K8 T1G0K8 20214606 PTHR24067:SF248 UBIQUITIN-CONJUGATING ENZYME E2 DORSAL INTERACTING PROTEIN 4 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650 post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein sumoylation#GO:0016925;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG114417|UniProtKB=T1EG15 T1EG15 20195517 PTHR11822:SF46 NADP-SPECIFIC ISOCITRATE DEHYDROGENASE ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nicotinamide nucleotide metabolic process#GO:0046496;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG185000|UniProtKB=T1FM92 T1FM92 20209941 PTHR21308:SF1 PHYTANOYL-COA ALPHA-HYDROXYLASE PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;hydroxylase#PC00122 HELRO|EnsemblGenome=HelroG112773|UniProtKB=T1EFM1 T1EFM1 20195373 PTHR15892:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN L30 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG173167|UniProtKB=T1F6H8 T1F6H8 20204427 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG182433|UniProtKB=T1FI68 T1FI68 20208517 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG180819|UniProtKB=T1FGB6 T1FGB6 20207865 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185344|UniProtKB=T1FMP6 T1FMP6 20210095 PTHR13904:SF0 PRE-MRNA SPLICING FACTOR PRP31 U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG191561|UniProtKB=T1FT30 T1FT30 20211977 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG188678|UniProtKB=T1FQ87 T1FQ87 20210984 PTHR14594:SF1 CENTROSOMAL PROTEIN OF 70 KDA CENTROSOMAL PROTEIN OF 70 KDA cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161669|UniProtKB=T1ERR7 T1ERR7 20199267 PTHR23103:SF17 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-LIKE PROTEIN 2 anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG185116|UniProtKB=T1FME9 T1FME9 20209998 PTHR10949:SF0 LIPOYL SYNTHASE LIPOYL SYNTHASE, MITOCHONDRIAL transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Lipoate_biosynthesis#P02750>Lipoate synthase#P03004 HELRO|EnsemblGenome=HelroG145007|UniProtKB=T1EJI0 T1EJI0 20196730 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG188102|UniProtKB=T1FPM9 T1FPM9 20210776 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178816|UniProtKB=T1FDS4 T1FDS4 20206973 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG182105|UniProtKB=T1FHR6 T1FHR6 20208365 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG63454|UniProtKB=T1FXG0 T1FXG0 20213508 PTHR22961:SF13 SER/THR PROTEIN KINASE-TRB TRIBBLES enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515 regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG101461|UniProtKB=T1ED47 T1ED47 20194499 PTHR18914:SF9 ALPHA CATENIN CATENIN ALPHA protein binding#GO:0005515;beta-catenin binding#GO:0008013;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;cell motility#GO:0048870;cell migration#GO:0016477 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;adherens junction#GO:0005912;anchoring junction#GO:0070161;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897 non-motor actin binding protein#PC00165 Alzheimer disease-presenilin pathway#P00004>alpha-catenin#P00133;Wnt signaling pathway#P00057>alpha-catenin#P01471 HELRO|EnsemblGenome=HelroG70216|UniProtKB=T1G034 T1G034 20214432 PTHR14359:SF6 HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE lyase activity#GO:0016829;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carboxy-lyase activity#GO:0016831;carbohydrate derivative binding#GO:0097367;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;ribonucleotide binding#GO:0032553 purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Coenzyme A biosynthesis#P02736>Pantothenoylcysteine decarboxylase#P02883;Coenzyme A biosynthesis#P02736>Pantothenate cysteine ligase#P02882 HELRO|EnsemblGenome=HelroG108854|UniProtKB=T1EEN1 T1EEN1 20195033 PTHR45629:SF15 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG189332|UniProtKB=T1FQZ0 T1FQZ0 20211237 PTHR44535:SF6 PROTEIN CBG16200 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG188565|UniProtKB=T1FQ47 T1FQ47 20210944 PTHR12461:SF106 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5 binding#GO:0005488;chromatin binding#GO:0003682;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;protein demethylase activity#GO:0140457 negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66358|UniProtKB=T1FYK1 T1FYK1 20213899 PTHR11771:SF153 LIPOXYGENASE LIPOXYGENASE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 lipid modification#GO:0030258;lipid oxidation#GO:0034440;cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG70006|UniProtKB=T1G014 T1G014 20214412 PTHR47977:SF18 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-36 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG171746|UniProtKB=T1F4L5 T1F4L5 20203764 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG190005|UniProtKB=T1FRK9 T1FRK9 20211456 PTHR23119:SF44 DISCS LARGE PROTEIN LAP4 protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;protein localization to plasma membrane#GO:0072659;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transport#GO:0006810;biological regulation#GO:0065007;macromolecule localization#GO:0033036;endosome to plasma membrane protein transport#GO:0099638;cellular localization#GO:0051641;protein transport#GO:0015031;regulation of biological quality#GO:0065008;establishment or maintenance of cell polarity#GO:0007163;cell adhesion#GO:0007155;receptor clustering#GO:0043113;endocytic recycling#GO:0032456;protein localization to membrane#GO:0072657;protein localization to synapse#GO:0035418;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;endosomal transport#GO:0016197;protein localization to cell periphery#GO:1990778;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;cell-cell adhesion#GO:0098609;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;cell-cell junction#GO:0005911;adherens junction#GO:0005912;cell junction#GO:0030054;synaptic membrane#GO:0097060;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;basal part of cell#GO:0045178;postsynapse#GO:0098794;anchoring junction#GO:0070161;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184880|UniProtKB=T1FM45 T1FM45 20209894 PTHR31952:SF1 CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG89038|UniProtKB=T1G782 T1G782 20216929 PTHR46098:SF1 TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG87042|UniProtKB=T1G6K9 T1G6K9 20216706 PTHR10454:SF232 CASPASE CASPASE-8 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;biological regulation#GO:0065007;programmed cell death#GO:0012501;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;cellular process#GO:0009987;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG177390|UniProtKB=T1FBL7 T1FBL7 20206216 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED translation regulator activity#GO:0045182 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG81195|UniProtKB=T1G4A9 T1G4A9 20215907 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194045|UniProtKB=T1FVM0 T1FVM0 20212866 PTHR46389:SF3 POLYCOMB GROUP PROTEIN PC POLYCOMB GROUP PROTEIN PC chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG162670|UniProtKB=T1ESZ9 T1ESZ9 20199699 PTHR19282:SF456 TETRASPANIN FI23944P1-RELATED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73535|UniProtKB=T1G1F4 T1G1F4 20214902 PTHR21148:SF11 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG167641|UniProtKB=T1EZL6 T1EZL6 20202016 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG148584|UniProtKB=T1EKA5 T1EKA5 20197005 PTHR24340:SF41 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN CEH-24-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG161801|UniProtKB=T1ERX5 T1ERX5 20199325 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173574|UniProtKB=T1F6Z3 T1F6Z3 20204592 PTHR10494:SF6 BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN NOGGIN regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of BMP signaling pathway#GO:0030514;regulation of BMP signaling pathway#GO:0030510;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG82909|UniProtKB=T1G4Y0 T1G4Y0 20216128 PTHR24347:SF454 SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLASE KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683 energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;energy reserve metabolic process#GO:0006112;signaling#GO:0023052;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977 protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG166828|UniProtKB=T1EYL1 T1EYL1 20201661 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81901|UniProtKB=T1G4K5 T1G4K5 20216003 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG176105|UniProtKB=T1FA48 T1FA48 20205697 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186595|UniProtKB=T1FP14 T1FP14 20210561 PTHR11668:SF300 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE-RELATED phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 protein phosphatase#PC00195 Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969;Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602 HELRO|EnsemblGenome=HelroG101510|UniProtKB=T1ED51 T1ED51 20194503 PTHR13803:SF39 SEC24-RELATED PROTEIN SECRETORY 24AB, ISOFORM A zinc ion binding#GO:0008270;SNARE binding#GO:0000149;cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 cellular component organization#GO:0016043;COPII-coated vesicle budding#GO:0090114;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050 vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;intracellular organelle#GO:0043229 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG83244|UniProtKB=T1G525 T1G525 20216173 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG75529|UniProtKB=T1G262 T1G262 20215160 PTHR12673:SF267 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG86224|UniProtKB=T1G687 T1G687 20216584 PTHR13809:SF48 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell division#GO:0051301;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;cell population proliferation#GO:0008283;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;asymmetric cell division#GO:0008356;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869 heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073 HELRO|EnsemblGenome=HelroG183853|UniProtKB=T1FK98 T1FK98 20209247 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163373|UniProtKB=T1ETZ0 T1ETZ0 20200040 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168835|UniProtKB=T1F108 T1F108 20202508 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188170|UniProtKB=T1FPQ3 T1FPQ3 20210800 PTHR11036:SF127 SEMAPHORIN SEMAPHORIN-1A binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 chemotaxis#GO:0006935;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;locomotion#GO:0040011;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cell migration#GO:0030334;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;taxis#GO:0042330;response to chemical#GO:0042221;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG177097|UniProtKB=T1FB81 T1FB81 20206080 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG159885|UniProtKB=T1EPI0 T1EPI0 20198480 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG109176|UniProtKB=T1EER0 T1EER0 20195062 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;tetrapyrrole binding#GO:0046906;binding#GO:0005488;steroid hydroxylase activity#GO:0008395 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;response to chemical#GO:0042221;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG95781|UniProtKB=T1G975 T1G975 20217622 PTHR48182:SF2 PROTEIN SERAC1 PROTEIN SERAC1 HELRO|EnsemblGenome=HelroG181968|UniProtKB=T1FHJ4 T1FHJ4 20208293 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86265|UniProtKB=T1G695 T1G695 20216592 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG152344|UniProtKB=T1EKR1 T1EKR1 20197161 PTHR11636:SF84 POU DOMAIN PITUITARY-SPECIFIC POSITIVE TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG186308|UniProtKB=T1FNY1 T1FNY1 20210528 PTHR10830:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;oligosaccharyltransferase complex#GO:0008250;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG185295|UniProtKB=T1FMM5 T1FMM5 20210074 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;cellular anatomical entity morphogenesis#GO:0032989;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle contraction#GO:0006936;developmental process#GO:0032502;system process#GO:0003008;cellular developmental process#GO:0048869;multicellular organismal process#GO:0032501 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;sarcomere#GO:0030017;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG175687|UniProtKB=T1F9J1 T1F9J1 20205490 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG66777|UniProtKB=T1FYQ8 T1FYQ8 20213956 PTHR11636:SF138 POU DOMAIN HOMEOBOX PROTEIN CEH-6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG194484|UniProtKB=T1FW40 T1FW40 20213036 PTHR46182:SF2 FI19480P1 FI19480P1 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;developmental process#GO:0032502;neuron migration#GO:0001764;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;system development#GO:0048731;neurogenesis#GO:0022008;cellular process#GO:0009987;cell differentiation#GO:0030154;cell migration#GO:0016477;multicellular organismal process#GO:0032501;cell motility#GO:0048870;nervous system development#GO:0007399 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG173218|UniProtKB=T1F6K9 T1F6K9 20204458 PTHR46169:SF30 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4 ISOFORM X1 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG174234|UniProtKB=T1F7U5 T1F7U5 20204894 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164231|UniProtKB=T1EV51 T1EV51 20200451 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192479|UniProtKB=T1FU01 T1FU01 20212297 PTHR15228:SF24 SPERMATHECAL PHYSIOLOGY VARIANT RHO-GAP DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185307|UniProtKB=T1FMN2 T1FMN2 20210081 PTHR48078:SF19 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED L-SERINE DEAMINASE lyase activity#GO:0016829;catalytic activity#GO:0003824 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 lyase#PC00144;dehydratase#PC00091 Isoleucine biosynthesis#P02748>Threonine dehydratase#P02995 HELRO|EnsemblGenome=HelroG193646|UniProtKB=T1FV80 T1FV80 20212726 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG156372|UniProtKB=T1ELU7 T1ELU7 20197547 PTHR24073:SF1242 DRAB5-RELATED RAS-RELATED PROTEIN RAB-18 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular component organization#GO:0016043;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;lipid droplet organization#GO:0034389;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG73151|UniProtKB=T1G1A9 T1G1A9 20214857 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183795|UniProtKB=T1FK73 T1FK73 20209222 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cell communication#GO:0010648 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HELRO|EnsemblGenome=HelroG67782|UniProtKB=T1FZ51 T1FZ51 20214099 PTHR10218:SF362 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA O SUBUNIT pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid prodynorphin pathway#P05916>G-protein#P06002;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085 HELRO|EnsemblGenome=HelroG113375|UniProtKB=T1EFS0 T1EFS0 20195422 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 mRNA capping factor#PC00145;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG83902|UniProtKB=T1G5B4 T1G5B4 20216261 PTHR12622:SF45 DELTEX-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG75592|UniProtKB=T1G267 T1G267 20215165 PTHR11537:SF294 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;axon terminus#GO:0043679;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell body#GO:0044297;postsynapse#GO:0098794;cell projection membrane#GO:0031253;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;protein-containing complex#GO:0032991;presynapse#GO:0098793;neuron projection#GO:0043005;cell leading edge#GO:0031252;cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;synaptic membrane#GO:0097060 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG186240|UniProtKB=T1FNV0 T1FNV0 20210497 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG172934|UniProtKB=T1F658 T1F658 20204307 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185876|UniProtKB=T1FND9 T1FND9 20210336 PTHR43826:SF3 GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 phosphate transmembrane transporter activity#GO:0005315;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;phosphate ion transport#GO:0006817;organophosphate ester transport#GO:0015748;transport#GO:0006810;inorganic anion transport#GO:0015698;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG178124|UniProtKB=T1FCS4 T1FCS4 20206623 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115024|UniProtKB=T1EG59 T1EG59 20195561 PTHR11679:SF2 VESICLE PROTEIN SORTING-ASSOCIATED SEC1 FAMILY DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;syntaxin binding#GO:0019905;binding#GO:0005488;SNARE binding#GO:0000149 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG183959|UniProtKB=T1FKC8 T1FKC8 20209277 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG77440|UniProtKB=T1G2X7 T1G2X7 20215425 PTHR12770:SF31 RUS1 FAMILY PROTEIN C16ORF58 RUS FAMILY MEMBER 1 HELRO|EnsemblGenome=HelroG116619|UniProtKB=T1EGG6 T1EGG6 20195668 PTHR13954:SF6 IRE1-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE tyrosine protein kinase receptor#PC00233;transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>Ire-1#P00144;Alzheimer disease-presenilin pathway#P00004>Ire-1 C-terminal fragment#P00125;Alzheimer disease-presenilin pathway#P00004>Ire-1 N-terminal fragment#P00110 HELRO|EnsemblGenome=HelroG192833|UniProtKB=T1FUC3 T1FUC3 20212419 PTHR12287:SF23 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN AROUSER, ISOFORM A-RELATED cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG157296|UniProtKB=T1EM89 T1EM89 20197689 PTHR13774:SF17 PHENAZINE BIOSYNTHESIS PROTEIN PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG194120|UniProtKB=T1FVQ1 T1FVQ1 20212897 PTHR10693:SF88 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN AT27578P mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167236|UniProtKB=T1EZ60 T1EZ60 20201860 PTHR12599:SF0 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE lyase#PC00144;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG167671|UniProtKB=T1EZN3 T1EZN3 20202033 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170819|UniProtKB=T1F3G9 T1F3G9 20203368 PTHR16008:SF4 F-BOX ONLY PROTEIN 4 F-BOX ONLY PROTEIN 4 cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG93602|UniProtKB=T1G8W7 T1G8W7 20217514 PTHR11909:SF422 CASEIN KINASE-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cell communication#GO:0007154 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG194277|UniProtKB=T1FVW1 T1FVW1 20212957 PTHR10233:SF14 TRANSLATION INITIATION FACTOR EIF-2B TRANSLATION INITIATION FACTOR EIF2B SUBUNIT DELTA translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045 translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG105574|UniProtKB=T1EDW3 T1EDW3 20194765 PTHR10253:SF12 POLYCOMB PROTEIN POLYCOMB PROTEIN EED molecular function activator activity#GO:0140677;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234;chromatin binding#GO:0003682;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nucleus#GO:0005634;PcG protein complex#GO:0031519;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG187943|UniProtKB=T1FPH6 T1FPH6 20210723 PTHR46024:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG187817|UniProtKB=T1FPE4 T1FPE4 20210691 PTHR23275:SF103 CABRIOLET.-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189047|UniProtKB=T1FQL2 T1FQL2 20211109 PTHR11216:SF176 EH DOMAIN EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 membrane protein complex#GO:0098796;clathrin-coated pit#GO:0005905;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;endomembrane system#GO:0012505;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68581|UniProtKB=T1FZH0 T1FZH0 20214218 PTHR15622:SF2 WD40 REPEAT PROTEIN ANAPHASE-PROMOTING COMPLEX SUBUNIT 4-LIKE WD40 DOMAIN-CONTAINING PROTEIN protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG161790|UniProtKB=T1ERX1 T1ERX1 20199321 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873 sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG168545|UniProtKB=T1F0P6 T1F0P6 20202396 PTHR11571:SF141 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE P transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220 HELRO|EnsemblGenome=HelroG176391|UniProtKB=T1FAH0 T1FAH0 20205819 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234 extracellular region#GO:0005576;vesicle#GO:0031982;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG165068|UniProtKB=T1EW88 T1EW88 20200838 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184217|UniProtKB=T1FKS5 T1FKS5 20209424 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG185604|UniProtKB=T1FN11 T1FN11 20210210 PTHR10019:SF18 SNF5 SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG158807|UniProtKB=T1ENA3 T1ENA3 20198053 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189989|UniProtKB=T1FRK3 T1FRK3 20211450 PTHR24068:SF581 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 J1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG187622|UniProtKB=T1FPB4 T1FPB4 20210661 PTHR10663:SF333 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PROTEIN MON2 HOMOLOG protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;protein localization to vacuole#GO:0072665;cytosolic transport#GO:0016482;establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;protein targeting to vacuole#GO:0006623 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG96872|UniProtKB=T1G9E0 T1G9E0 20217687 PTHR24351:SF110 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;TORC1 signaling#GO:0038202;cell communication#GO:0007154 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 protein modifying enzyme#PC00260 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;Interleukin signaling pathway#P00036>p90RSK#P00964;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG194398|UniProtKB=T1FW07 T1FW07 20213003 PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;kinetochore organization#GO:0051383;cellular component organization or biogenesis#GO:0071840;kinetochore assembly#GO:0051382;organelle assembly#GO:0070925;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG113120|UniProtKB=T1EFQ3 T1EFQ3 20195405 PTHR45630:SF7 CATION-TRANSPORTING ATPASE-RELATED FI03653P ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;localization#GO:0051179;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG65278|UniProtKB=T1FY53 T1FY53 20213751 PTHR12835:SF5 BIOTIN PROTEIN LIGASE BIOTIN--PROTEIN LIGASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity, acting on a protein#GO:0140096;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142 HELRO|EnsemblGenome=HelroG188325|UniProtKB=T1FPV8 T1FPV8 20210855 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P response to stimulus#GO:0050896;protein folding#GO:0006457;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein refolding#GO:0042026;protein maturation#GO:0051604;gene expression#GO:0010467;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;response to heat#GO:0009408;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG77310|UniProtKB=T1G2W0 T1G2W0 20215408 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89732|UniProtKB=T1G7G7 T1G7G7 20217014 PTHR12896:SF1 PAX6 NEIGHBOR PROTEIN PAXNEB ELONGATOR COMPLEX PROTEIN 4 tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;elongator holoenzyme complex#GO:0033588 HELRO|EnsemblGenome=HelroG176057|UniProtKB=T1FA35 T1FA35 20205684 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71353|UniProtKB=T1G0K1 T1G0K1 20214599 PTHR45701:SF3 SYNAPTOBREVIN FAMILY MEMBER SYNAPTOBREVIN SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090 membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;vesicle fusion#GO:0006906;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050 cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;SNARE complex#GO:0031201;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986 HELRO|EnsemblGenome=HelroG101643|UniProtKB=T1ED62 T1ED62 20194514 PTHR43272:SF32 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 ligase#PC00142 HELRO|EnsemblGenome=HelroG193976|UniProtKB=T1FVJ0 T1FVJ0 20212836 PTHR47765:SF2 3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN EXONUCLEASE MUT-7 HOMOLOG HELRO|EnsemblGenome=HelroG188234|UniProtKB=T1FPS9 T1FPS9 20210826 PTHR15960:SF5 LD44032P LD44032P protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;ESCRT I complex#GO:0000813;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HELRO|EnsemblGenome=HelroG93424|UniProtKB=T1G8V8 T1G8V8 20217505 PTHR10221:SF9 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933 intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP#P00670;General transcription regulation#P00023>TBP-associated factors#P00658 HELRO|EnsemblGenome=HelroG146034|UniProtKB=T1EJP6 T1EJP6 20196796 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173259|UniProtKB=T1F6M1 T1F6M1 20204470 PTHR11462:SF60 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to steroid hormone#GO:0048545;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;response to lipid#GO:0033993;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;regulation of cell cycle#GO:0051726;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG162203|UniProtKB=T1ESC8 T1ESC8 20199478 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160942|UniProtKB=T1EQW1 T1EQW1 20198961 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65397|UniProtKB=T1FY73 T1FY73 20213771 PTHR12888:SF0 PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12 PEROXISOME ASSEMBLY PROTEIN 12 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component organization#GO:0016043;peroxisome organization#GO:0007031;cellular process#GO:0009987 microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG189144|UniProtKB=T1FQQ1 T1FQQ1 20211148 PTHR13844:SF53 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D LD45195P nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG77679|UniProtKB=T1G323 T1G323 20215471 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;developmental process#GO:0032502 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG185150|UniProtKB=T1FMG2 T1FMG2 20210011 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160789|UniProtKB=T1EQQ3 T1EQQ3 20198903 PTHR12400:SF110 INOSITOL POLYPHOSPHATE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 kinase#PC00137 HELRO|EnsemblGenome=HelroG90685|UniProtKB=T1G7U4 T1G7U4 20217141 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185908|UniProtKB=T1FNF5 T1FNF5 20210352 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG126209|UniProtKB=T1EH87 T1EH87 20195937 PTHR22722:SF14 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED MEGALIN, ISOFORM A binding#GO:0005488;hormone binding#GO:0042562 receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG193835|UniProtKB=T1FVE6 T1FVE6 20212792 PTHR13980:SF15 CDC68 RELATED FACT COMPLEX SUBUNIT SPT16 nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;protein carrier activity#GO:0140597;chromatin binding#GO:0003682;molecular carrier activity#GO:0140104;binding#GO:0005488 gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG71298|UniProtKB=T1G0J2 T1G0J2 20214590 PTHR12805:SF0 KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG DNA_RNA-BINDING PROTEIN KIN17 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG185002|UniProtKB=T1FM94 T1FM94 20209943 PTHR10516:SF443 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FK506-BINDING PROTEIN 59 catalytic activity, acting on a protein#GO:0140096;cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity#GO:0003824 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG177499|UniProtKB=T1FBT1 T1FBT1 20206280 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167446|UniProtKB=T1EZE1 T1EZE1 20201941 PTHR11103:SF10 SLR1189 PROTEIN HOMOCYSTEINE S-METHYLTRANSFERASE 1-RELATED Methionine biosynthesis#P02753>Homocysteine transmethylase#P03024;Formyltetrahydrofolate biosynthesis#P02743>Cobalamin dependent homocysteine transmethylase#P02953 HELRO|EnsemblGenome=HelroG158326|UniProtKB=T1EMN6 T1EMN6 20197836 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG147316|UniProtKB=T1EJZ2 T1EJZ2 20196892 PTHR23235:SF164 KRUEPPEL-LIKE TRANSCRIPTION FACTOR CABUT, ISOFORM A sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG143678|UniProtKB=T1EJB7 T1EJB7 20196667 PTHR22957:SF497 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN ECOTROPIC VIRAL INTEGRATION SITE 5 ORTHOLOG enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG192903|UniProtKB=T1FUE7 T1FUE7 20212443 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110749|UniProtKB=T1EF50 T1EF50 20195202 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG94235|UniProtKB=T1G8Z6 T1G8Z6 20217543 PTHR31624:SF4 UPF0472 PROTEIN C16ORF72 HUWE1 ASSOCIATED PROTEIN MODIFYING STRESS RESPONSES HELRO|EnsemblGenome=HelroG188839|UniProtKB=T1FQE8 T1FQE8 20211045 PTHR12587:SF20 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA, ISOFORM E protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;synapse organization#GO:0050808;cellular component organization#GO:0016043 presynapse#GO:0098793;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynaptic active zone#GO:0048786;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177595|UniProtKB=T1FBX1 T1FBX1 20206320 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181816|UniProtKB=T1FHD3 T1FHD3 20208232 PTHR31697:SF2 INTEGRATOR COMPLEX SUBUNIT 5 INTEGRATOR COMPLEX SUBUNIT 5 gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;snRNA processing#GO:0016180;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;integrator complex#GO:0032039;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG71319|UniProtKB=T1G0J5 T1G0J5 20214593 PTHR24347:SF393 SERINE/THREONINE-PROTEIN KINASE SPAGHETTI-SQUASH ACTIVATOR, ISOFORM C transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877 HELRO|EnsemblGenome=HelroG84431|UniProtKB=T1G5I5 T1G5I5 20216332 PTHR10623:SF6 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER EB1, ISOFORM F-RELATED binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;intracellular protein localization#GO:0008104;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;cellular process#GO:0009987;protein localization to microtubule cytoskeleton#GO:0072698;cellular component assembly#GO:0022607;regulation of microtubule cytoskeleton organization#GO:0070507;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule-based process#GO:0032886;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;protein localization to cytoskeleton#GO:0044380;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493 supramolecular fiber#GO:0099512;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule end#GO:1990752;cytoplasmic microtubule#GO:0005881;microtubule plus-end#GO:0035371;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG161674|UniProtKB=T1ERS1 T1ERS1 20199271 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175608|UniProtKB=T1F9F2 T1F9F2 20205451 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG62761|UniProtKB=T1FX47 T1FX47 20213395 PTHR14911:SF13 THUMP DOMAIN-CONTAINING TRNA (GUANINE(6)-N(2))-METHYLTRANSFERASE THUMP3 catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;tRNA methylation#GO:0030488;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188228|UniProtKB=T1FPS6 T1FPS6 20210823 PTHR47658:SF1 HIGH MOBILITY GROUP B PROTEIN 12-RELATED MEIOSIS INITIATOR PROTEIN HELRO|EnsemblGenome=HelroG94076|UniProtKB=T1G8Y9 T1G8Y9 20217536 PTHR23180:SF399 CENTAURIN/ARF BLOWN FUSE, ISOFORM A-RELATED enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029 endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659 HELRO|EnsemblGenome=HelroG85573|UniProtKB=T1G5Z9 T1G5Z9 20216496 PTHR11995:SF14 NADH DEHYDROGENASE NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;electron transfer activity#GO:0009055;monoatomic cation transmembrane transporter activity#GO:0008324;oxidoreductase activity, acting on NAD(P)H#GO:0016651;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;monoatomic ion transport#GO:0006811;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185642|UniProtKB=T1FN30 T1FN30 20210229 PTHR23049:SF71 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;myosin binding#GO:0017022 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG85596|UniProtKB=T1G602 T1G602 20216499 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;detection of stimulus#GO:0051606;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987;response to radiation#GO:0009314;signal transduction#GO:0007165;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to radiation#GO:0071478;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG192339|UniProtKB=T1FTU4 T1FTU4 20212241 PTHR11746:SF199 O-METHYLTRANSFERASE DES-METHYL DIF-1 METHYLTRANSFERASE A-RELATED methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171 cellular process#GO:0009987;metabolic process#GO:0008152;biosynthetic process#GO:0009058;methylation#GO:0032259 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG76461|UniProtKB=T1G2K1 T1G2K1 20215299 PTHR16092:SF14 SEC3/SYNTAXIN-RELATED EXOCYST COMPLEX COMPONENT 1 phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546 localization within membrane#GO:0051668;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;secretion by cell#GO:0032940;post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;establishment of localization#GO:0051234;cellular process#GO:0009987;export from cell#GO:0140352;Golgi to plasma membrane transport#GO:0006893;vesicle-mediated transport#GO:0016192 intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;cell periphery#GO:0071944;cell cortex#GO:0005938;membrane#GO:0016020;cytoplasm#GO:0005737;exocyst#GO:0000145;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG66029|UniProtKB=T1FYG0 T1FYG0 20213858 PTHR43053:SF4 GLYCOSIDASE FAMILY 31 RE74917P glucosidase#PC00108;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG86660|UniProtKB=T1G6F1 T1G6F1 20216648 PTHR23086:SF101 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 59B, ISOFORM J-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG183634|UniProtKB=T1FJY9 T1FJY9 20209138 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185133|UniProtKB=T1FMF8 T1FMF8 20210007 PTHR18884:SF69 SEPTIN SEPTIN-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 macromolecule localization#GO:0033036;cell cycle#GO:0007049;cellular process#GO:0009987;cell division#GO:0051301;cell cycle process#GO:0022402;cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;intracellular protein localization#GO:0008104 intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG194454|UniProtKB=T1FW26 T1FW26 20213022 PTHR43612:SF3 TRIFUNCTIONAL ENZYME SUBUNIT ALPHA TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;oxidoreductase complex#GO:1990204;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG162707|UniProtKB=T1ET14 T1ET14 20199714 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182539|UniProtKB=T1FIC0 T1FIC0 20208569 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG108190|UniProtKB=T1EEG6 T1EEG6 20194968 PTHR24056:SF233 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 9 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108808|UniProtKB=T1EEM7 T1EEM7 20195029 PTHR15608:SF0 SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2 17S U2 SNRNP COMPLEX COMPONENT HTATSF1 nucleic acid binding#GO:0003676;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;RNA binding#GO:0003723;chromatin-protein adaptor activity#GO:0140463 macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;intracellular protein localization#GO:0008104;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;protein localization to organelle#GO:0033365;RNA splicing, via transesterification reactions#GO:0000375;localization#GO:0051179;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA metabolic process#GO:0016070 chromosome#GO:0005694;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;site of double-strand break#GO:0035861;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG191184|UniProtKB=T1FSQ0 T1FSQ0 20211847 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG161720|UniProtKB=T1ERU0 T1ERU0 20199290 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG188181|UniProtKB=T1FPR0 T1FPR0 20210807 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178457|UniProtKB=T1FD68 T1FD68 20206767 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168055|UniProtKB=T1F043 T1F043 20202193 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG186143|UniProtKB=T1FNQ3 T1FNQ3 20210450 PTHR11588:SF429 TUBULIN TUBULIN BETA 8B-RELATED binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198 microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HELRO|EnsemblGenome=HelroG90033|UniProtKB=T1G7K1 T1G7K1 20217048 PTHR45617:SF166 LEUCINE RICH REPEAT FAMILY PROTEIN LRRNT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG97204|UniProtKB=T1G9G0 T1G9G0 20217707 PTHR24416:SF333 TYROSINE-PROTEIN KINASE RECEPTOR EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;binding#GO:0005488;collagen binding#GO:0005518;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714 regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of intracellular signal transduction#GO:1902531;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signaling#GO:0023056;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of intracellular signal transduction#GO:1902533;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG144002|UniProtKB=T1EJD3 T1EJD3 20196683 PTHR48043:SF168 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 HELRO|EnsemblGenome=HelroG70925|UniProtKB=T1G0E4 T1G0E4 20214542 PTHR46712:SF1 PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1 PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 HELRO|EnsemblGenome=HelroG135178|UniProtKB=T1EI70 T1EI70 20196270 PTHR20974:SF0 UPF0585 PROTEIN CG18661 UPF0585 PROTEIN CG18661 HELRO|EnsemblGenome=HelroG71055|UniProtKB=T1G0G1 T1G0G1 20214559 PTHR10856:SF44 CORONIN CORONIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;actin filament#GO:0005884 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG193781|UniProtKB=T1FVC6 T1FVC6 20212772 PTHR12949:SF0 RNA POLYMERASE III DNA DIRECTED -RELATED DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG174285|UniProtKB=T1F7X9 T1F7X9 20204928 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172961|UniProtKB=T1F677 T1F677 20204326 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170127|UniProtKB=T1F2P2 T1F2P2 20203091 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190406|UniProtKB=T1FRY7 T1FRY7 20211584 PTHR47634:SF26 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED SERINE-ARGININE PROTEIN KINASE AT 79D-RELATED protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG194516|UniProtKB=T1FW53 T1FW53 20213049 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG181554|UniProtKB=T1FH36 T1FH36 20208135 PTHR11311:SF30 SPONDIN KIELIN_CHORDIN-LIKE PROTEIN cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG84358|UniProtKB=T1G5I0 T1G5I0 20216327 PTHR24115:SF1008 KINESIN-RELATED KINESIN-LIKE PROTEIN SUBITO catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG114003|UniProtKB=T1EFY1 T1EFY1 20195483 PTHR10224:SF17 ES1 PROTEIN HOMOLOG, MITOCHONDRIAL GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 3A, MITOCHONDRIAL ISOFORM X1 HELRO|EnsemblGenome=HelroG63997|UniProtKB=T1FXN3 T1FXN3 20213581 PTHR20920:SF5 RPE-SPONDIN VEXED, ISOFORM B HELRO|EnsemblGenome=HelroG189827|UniProtKB=T1FRE5 T1FRE5 20211392 PTHR14134:SF2 E3 UBIQUITIN-PROTEIN LIGASE RAD18 E3 UBIQUITIN-PROTEIN LIGASE RAD18 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;DNA replication#GO:0006260;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage tolerance#GO:0006301;cellular response to stress#GO:0033554;DNA damage response#GO:0006974 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG98648|UniProtKB=T1G9P2 T1G9P2 20217788 PTHR11477:SF53 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN IP08861P-RELATED transcription regulator activity#GO:0140110;transcription elongation factor activity#GO:0003711 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185811|UniProtKB=T1FNB7 T1FNB7 20210314 PTHR10598:SF0 SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG194929|UniProtKB=T1FWK9 T1FWK9 20213204 PTHR16188:SF14 PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C GEO07393P1 protein serine/threonine phosphatase inhibitor activity#GO:0004865;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG87823|UniProtKB=T1G6V8 T1G6V8 20216805 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 ligase#PC00142 HELRO|EnsemblGenome=HelroG92276|UniProtKB=T1G8D7 T1G8D7 20217334 PTHR10026:SF70 CYCLIN CYCLIN-Q cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 kinase activator#PC00138;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG156251|UniProtKB=T1ELT4 T1ELT4 20197534 PTHR48094:SF28 PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED PROTEIN DJ-1ALPHA-RELATED hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;monocarboxylic acid biosynthetic process#GO:0072330;response to oxidative stress#GO:0006979;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;alcohol biosynthetic process#GO:0046165;response to stress#GO:0006950;cellular response to toxic substance#GO:0097237;aldehyde catabolic process#GO:0046185;detoxification#GO:0098754;biosynthetic process#GO:0009058;response to chemical#GO:0042221;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;carboxylic acid biosynthetic process#GO:0046394;cellular response to stimulus#GO:0051716;carboxylic acid metabolic process#GO:0019752;ketone metabolic process#GO:0042180;cellular detoxification of aldehyde#GO:0110095;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;response to toxic substance#GO:0009636;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG110400|UniProtKB=T1EF19 T1EF19 20195171 PTHR10921:SF4 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 establishment of spindle orientation#GO:0051294;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;organelle transport along microtubule#GO:0072384;chromosome localization#GO:0050000;establishment of vesicle localization#GO:0051650;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle localization#GO:0051653;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;nuclear division#GO:0000280;establishment or maintenance of cell polarity#GO:0007163;centrosome localization#GO:0051642;establishment of organelle localization#GO:0051656;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;centrosome cycle#GO:0007098;protein polymerization#GO:0051258;cellular component organization#GO:0016043;microtubule nucleation#GO:0007020;microtubule polymerization#GO:0046785;vesicle cytoskeletal trafficking#GO:0099518;mitotic cell cycle process#GO:1903047;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;transport#GO:0006810;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;cell migration#GO:0016477;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of spindle localization#GO:0051293;vesicle localization#GO:0051648;microtubule polymerization or depolymerization#GO:0031109;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;organelle localization#GO:0051640;cell motility#GO:0048870;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;establishment of cell polarity#GO:0030010;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049 chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;chromosome#GO:0005694;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG108880|UniProtKB=T1EEN3 T1EEN3 20195035 PTHR12670:SF21 CERAMIDASE NEUTRAL CERAMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid catabolic process#GO:0016042;alcohol biosynthetic process#GO:0046165;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;oxoacid metabolic process#GO:0043436;ceramide metabolic process#GO:0006672;sphingoid biosynthetic process#GO:0046520;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG90909|UniProtKB=T1G7X8 T1G7X8 20217175 PTHR45620:SF42 PDF RECEPTOR-LIKE PROTEIN-RELATED G PROTEIN-COUPLED RECEPTOR SEB-2 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG162041|UniProtKB=T1ES66 T1ES66 20199416 PTHR12756:SF11 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 1 metallopeptidase activity#GO:0008237;binding#GO:0005488;carboxypeptidase activity#GO:0004180;metallocarboxypeptidase activity#GO:0004181;protein binding#GO:0005515;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metalloexopeptidase activity#GO:0008235;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG78455|UniProtKB=T1G3B9 T1G3B9 20215567 PTHR12969:SF7 NGD5/OSM-6/IFT52 INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;cilium assembly#GO:0060271;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705 intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814 HELRO|EnsemblGenome=HelroG170216|UniProtKB=T1F2S8 T1F2S8 20203127 PTHR10156:SF0 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG89499|UniProtKB=T1G7D8 T1G7D8 20216985 PTHR11636:SF70 POU DOMAIN INHIBITORY POU PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG79715|UniProtKB=T1G3S6 T1G3S6 20215724 PTHR45667:SF9 S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN MITOCHONDRIAL S-ADENOSYLMETHIONINE CARRIER PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 mitochondrial carrier protein#PC00158 HELRO|EnsemblGenome=HelroG183359|UniProtKB=T1FJI3 T1FJI3 20208982 PTHR31905:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 58 PROTEIN MIX23 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG135982|UniProtKB=T1EIB3 T1EIB3 20196313 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG169460|UniProtKB=T1F1Y9 T1F1Y9 20202839 PTHR24034:SF111 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE64043P external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG158471|UniProtKB=T1EMU1 T1EMU1 20197891 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91246|UniProtKB=T1G817 T1G817 20217214 PTHR15192:SF8 PROTEIN CBG05349 OXIDATIVE STRESS INDUCED GROWTH INHIBITOR HOMOLOG OSGN-1 HELRO|EnsemblGenome=HelroG74189|UniProtKB=T1G1N4 T1G1N4 20214982 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG186038|UniProtKB=T1FNK8 T1FNK8 20210405 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72617|UniProtKB=T1G126 T1G126 20214774 PTHR12297:SF18 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 2A cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG145735|UniProtKB=T1EJM5 T1EJM5 20196775 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG139357|UniProtKB=T1EIY5 T1EIY5 20196535 PTHR13976:SF25 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED RNA-BINDING PROTEIN FUSILLI nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185645|UniProtKB=T1FN32 T1FN32 20210231 PTHR45699:SF3 60S ACIDIC RIBOSOMAL PROTEIN P0 LARGE RIBOSOMAL SUBUNIT PROTEIN UL10 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;structural molecule activity#GO:0005198;RNA binding#GO:0003723 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG188686|UniProtKB=T1FQ92 T1FQ92 20210989 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133 HELRO|EnsemblGenome=HelroG186075|UniProtKB=T1FNM8 T1FNM8 20210425 PTHR14978:SF0 BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN BETA-CATENIN-LIKE PROTEIN 1 mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974 HELRO|EnsemblGenome=HelroG165384|UniProtKB=T1EWP4 T1EWP4 20200994 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161033|UniProtKB=T1ER12 T1ER12 20199012 PTHR11046:SF31 OLIGORIBONUCLEASE, MITOCHONDRIAL THAP9-LIKE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159137|UniProtKB=T1ENN0 T1ENN0 20198180 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158888|UniProtKB=T1END7 T1END7 20198087 PTHR10129:SF50 TRANSCRIPTION FACTOR MAF TRAFFIC JAM, ISOFORM C DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG176981|UniProtKB=T1FB33 T1FB33 20206032 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG125154|UniProtKB=T1EH46 T1EH46 20195896 PTHR45787:SF1 LD11652P BEADEX, ISOFORM D transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG142725|UniProtKB=T1EJ71 T1EJ71 20196621 PTHR24416:SF489 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG179216|UniProtKB=T1FED3 T1FED3 20207182 PTHR13284:SF4 GH01354P RIBOSOMAL PROTEIN EL8_EL30_ES12_GADD45 DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;mRNA 3'-UTR binding#GO:0003730;protein-containing complex binding#GO:0044877;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG192800|UniProtKB=T1FUB2 T1FUB2 20212408 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG78116|UniProtKB=T1G382 T1G382 20215530 PTHR12982:SF0 PHOSPHATIDYLINOSITOL GLYCAN, CLASS C PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;glycolipid biosynthetic process#GO:0009247;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG134860|UniProtKB=T1EI61 T1EI61 20196261 PTHR13605:SF4 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7 ENDOPLASMIC RETICULUM MEMBRANE PROTEIN COMPLEX SUBUNIT 7 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG177674|UniProtKB=T1FC20 T1FC20 20206369 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175948|UniProtKB=T1F9Y2 T1F9Y2 20205631 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69844|UniProtKB=T1FZY9 T1FZY9 20214387 PTHR22792:SF166 LUPUS LA PROTEIN-RELATED LUPUS LA PROTEIN HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183602|UniProtKB=T1FJW9 T1FJW9 20209118 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161916|UniProtKB=T1ES15 T1ES15 20199365 PTHR15577:SF2 ZINC FINGER CONTAINING PROTEIN ZINC FINGER PROTEIN 318 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG186036|UniProtKB=T1FNK6 T1FNK6 20210403 PTHR12266:SF38 NA+/CA2+ K+ INDEPENDENT EXCHANGER GH07338P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;monoatomic ion homeostasis#GO:0050801;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG174367|UniProtKB=T1F817 T1F817 20204966 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG71703|UniProtKB=T1G0Q3 T1G0Q3 20214651 PTHR24347:SF393 SERINE/THREONINE-PROTEIN KINASE SPAGHETTI-SQUASH ACTIVATOR, ISOFORM C phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877 HELRO|EnsemblGenome=HelroG180359|UniProtKB=T1FFT7 T1FFT7 20207686 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG71060|UniProtKB=T1G0G2 T1G0G2 20214560 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG66868|UniProtKB=T1FYS1 T1FYS1 20213969 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157832|UniProtKB=T1EMG6 T1EMG6 20197766 PTHR22753:SF14 TRANSMEMBRANE PROTEIN 68 DGAT1_2-INDEPENDENT ENZYME SYNTHESIZING STORAGE LIPIDS membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG64152|UniProtKB=T1FXQ3 T1FXQ3 20213601 PTHR12547:SF190 CCCH ZINC FINGER/TIS11-RELATED PROTEIN TIS11 protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;protein-RNA adaptor activity#GO:0140517;molecular adaptor activity#GO:0060090;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182 biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;RNA catabolic process#GO:0006401 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185323|UniProtKB=T1FMN8 T1FMN8 20210087 PTHR10540:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED COP9 SIGNALOSOME COMPLEX SUBUNIT 6 nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG176001|UniProtKB=T1FA06 T1FA06 20205655 PTHR13066:SF2 BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN GOLGIN-45 cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;Golgi organization#GO:0007030;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;protein localization to cell periphery#GO:1990778;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG123811|UniProtKB=T1EGZ1 T1EGZ1 20195841 PTHR46803:SF5 E3 UBIQUITIN-PROTEIN LIGASE CHIP E3 UBIQUITIN-PROTEIN LIGASE CHIP protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein-folding chaperone binding#GO:0051087 response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;response to misfolded protein#GO:0051788;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of metabolic process#GO:0009893;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of proteolysis#GO:0030162;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular response to topologically incorrect protein#GO:0035967;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;cellular response to misfolded protein#GO:0071218 supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;sarcomere#GO:0030017;myofibril#GO:0030016;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;I band#GO:0031674 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>CHIP#P01214 HELRO|EnsemblGenome=HelroG103307|UniProtKB=T1EDF5 T1EDF5 20194607 PTHR48092:SF26 KNIRPS-RELATED PROTEIN-RELATED RETINOIC ACID RECEPTOR RXR-ALPHA-B-LIKE sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG68668|UniProtKB=T1FZH9 T1FZH9 20214227 PTHR24057:SF82 GLYCOGEN SYNTHASE KINASE-3 ALPHA PROTEIN KINASE SHAGGY-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;regulation of microtubule-based process#GO:0032886;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;positive regulation of proteasomal protein catabolic process#GO:1901800;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of signal transduction#GO:0009968;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of ubiquitin-dependent protein catabolic process#GO:2000058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PDGF signaling pathway#P00047>GSK3#P01153;Angiogenesis#P00005>GSK3beta#P00211;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175 HELRO|EnsemblGenome=HelroG134299|UniProtKB=T1EI41 T1EI41 20196241 PTHR11267:SF212 T-BOX PROTEIN-RELATED LP04777P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;heart development#GO:0007507;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;cell fate specification#GO:0001708;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG177866|UniProtKB=T1FCE0 T1FCE0 20206489 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG192998|UniProtKB=T1FUH9 T1FUH9 20212475 PTHR11215:SF1 METAL DEPENDENT HYDROLASE - RELATED MYG1 EXONUCLEASE hydrolase#PC00121 HELRO|EnsemblGenome=HelroG177823|UniProtKB=T1FCB8 T1FCB8 20206467 PTHR46927:SF4 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG166674|UniProtKB=T1EYC3 T1EYC3 20201573 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG186309|UniProtKB=T1FNY2 T1FNY2 20210529 PTHR11071:SF547 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG114129|UniProtKB=T1EFZ3 T1EFZ3 20195495 PTHR10909:SF250 ELECTRON TRANSPORT OXIDOREDUCTASE ACYL-COENZYME A OXIDASE-RELATED lipid binding#GO:0008289;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;binding#GO:0005488;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lipid modification#GO:0030258;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG63524|UniProtKB=T1FXG9 T1FXG9 20213517 PTHR24416:SF527 TYROSINE-PROTEIN KINASE RECEPTOR PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of intracellular signal transduction#GO:1902531;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG96289|UniProtKB=T1G9B2 T1G9B2 20217659 PTHR11630:SF26 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM7 binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853 DNA damage response#GO:0006974;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;MCM complex#GO:0042555;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG94730|UniProtKB=T1G926 T1G926 20217573 PTHR24056:SF0 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 7 cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;regulation of cellular process#GO:0050794;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;regulation of cell cycle#GO:0051726;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG115173|UniProtKB=T1EG69 T1EG69 20195571 PTHR10856:SF0 CORONIN CORONIN actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;actin filament#GO:0005884;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;membrane#GO:0016020;cell periphery#GO:0071944;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG102182|UniProtKB=T1ED86 T1ED86 20194538 PTHR24303:SF31 HEME-BINDING MONOOXYGENASE FAMILY CYTOCHROME P450 307A1-RELATED oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG78261|UniProtKB=T1G3A0 T1G3A0 20215548 PTHR46259:SF1 ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1 ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG184944|UniProtKB=T1FM71 T1FM71 20209920 PTHR10551:SF9 FASCIN FASCIN-2 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;supramolecular fiber organization#GO:0097435;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cellular component assembly#GO:0022607;cell migration#GO:0016477;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG193509|UniProtKB=T1FV25 T1FV25 20212671 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG156842|UniProtKB=T1EM17 T1EM17 20197617 PTHR19229:SF275 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2 ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;lipid transport#GO:0006869 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG100685|UniProtKB=T1ED11 T1ED11 20194463 PTHR10572:SF24 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;isoprenoid metabolic process#GO:0006720;isoprenoid biosynthetic process#GO:0008299;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;microbody#GO:0042579;membrane#GO:0016020;cytoplasm#GO:0005737;peroxisomal membrane#GO:0005778;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165 reductase#PC00198 Cholesterol biosynthesis#P00014>Hydroxymethyl glutaryl CoA reductase#P00491 HELRO|EnsemblGenome=HelroG64261|UniProtKB=T1FXR9 T1FXR9 20213617 PTHR12884:SF0 60S RIBOSOMAL PROTEIN L29 60S RIBOSOMAL PROTEIN L29 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG162453|UniProtKB=T1ESP2 T1ESP2 20199592 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193260|UniProtKB=T1FUT1 T1FUT1 20212577 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG151695|UniProtKB=T1EKL9 T1EKL9 20197119 PTHR11158:SF30 MSF1/PX19 RELATED PRELI_MSF1 DOMAIN-CONTAINING PROTEIN lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;lipid localization#GO:0010876;phospholipid transport#GO:0015914;lipid transport#GO:0006869;organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG192380|UniProtKB=T1FTV9 T1FTV9 20212256 PTHR22897:SF8 QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE SULFHYDRYL OXIDASE catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;extracellular matrix assembly#GO:0085029;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxidoreductase#PC00176;oxidase#PC00175 HELRO|EnsemblGenome=HelroG69873|UniProtKB=T1FZZ2 T1FZZ2 20214390 PTHR43073:SF5 DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 metabolic process#GO:0008152;pyrimidine nucleobase metabolic process#GO:0006206;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleobase catabolic process#GO:0046113 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydrogenase#PC00092;oxidoreductase#PC00176 Pyrimidine Metabolism#P02771>Dihydrouracil Dehydrogenase#P03128 HELRO|EnsemblGenome=HelroG158811|UniProtKB=T1ENA7 T1ENA7 20198057 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG180434|UniProtKB=T1FFX1 T1FFX1 20207720 PTHR10744:SF9 40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US17 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG170691|UniProtKB=T1F3B6 T1F3B6 20203315 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG160499|UniProtKB=T1EQB8 T1EQB8 20198768 PTHR15437:SF6 TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565 HELRO|EnsemblGenome=HelroG157379|UniProtKB=T1EMA5 T1EMA5 20197705 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181959|UniProtKB=T1FHI7 T1FHI7 20208286 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181863|UniProtKB=T1FHE7 T1FHE7 20208246 PTHR46458:SF5 BLR2807 PROTEIN GLOBIN DOMAIN-CONTAINING PROTEIN molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;binding#GO:0005488 response to stimulus#GO:0050896;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;response to hypoxia#GO:0001666;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 transporter#PC00227 HELRO|EnsemblGenome=HelroG179140|UniProtKB=T1FE83 T1FE83 20207132 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174863|UniProtKB=T1F8J9 T1F8J9 20205148 PTHR28589:SF1 28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS34 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG77725|UniProtKB=T1G332 T1G332 20215480 PTHR12246:SF26 PALMITOYLTRANSFERASE ZDHHC16 PALMITOYLTRANSFERASE acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186015|UniProtKB=T1FNJ9 T1FNJ9 20210396 PTHR12411:SF16 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN B catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987 lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG67964|UniProtKB=T1FZ86 T1FZ86 20214134 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG182635|UniProtKB=T1FII6 T1FII6 20208635 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156955|UniProtKB=T1EM40 T1EM40 20197640 PTHR45732:SF23 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 cellular localization#GO:0051641;localization#GO:0051179;anterograde axonal transport#GO:0008089;lysosomal transport#GO:0007041;axonal transport#GO:0098930;microtubule-based transport#GO:0099111;microtubule-based movement#GO:0007018;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle-mediated transport#GO:0016192;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosomal membrane#GO:0005765;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG90686|UniProtKB=T1G7U5 T1G7U5 20217142 PTHR14614:SF177 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170 regulation of biological process#GO:0050789;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105332|UniProtKB=T1EDT8 T1EDT8 20194740 PTHR24006:SF664 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG180640|UniProtKB=T1FG41 T1FG41 20207790 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG185706|UniProtKB=T1FN62 T1FN62 20210260 PTHR44090:SF1 WD REPEAT-CONTAINING PROTEIN 61 SUPERKILLER COMPLEX PROTEIN 8 Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023 HELRO|EnsemblGenome=HelroG193092|UniProtKB=T1FUM3 T1FUM3 20212519 PTHR15077:SF12 FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91579|UniProtKB=T1G858 T1G858 20217255 PTHR13169:SF0 UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN UBIQUITIN-LIKE PROTEIN 3 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG80241|UniProtKB=T1G3Z0 T1G3Z0 20215788 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG77483|UniProtKB=T1G2Y4 T1G2Y4 20215432 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE lyase activity#GO:0016829;molecular transducer activity#GO:0060089;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653 phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG83212|UniProtKB=T1G521 T1G521 20216169 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181338|UniProtKB=T1FGW8 T1FGW8 20208067 PTHR11258:SF22 2-5 OLIGOADENYLATE SYNTHETASE 2'-5'-OLIGOADENYLATE SYNTHETASE 1 DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;adenylyltransferase activity#GO:0070566;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176661|UniProtKB=T1FAS0 T1FAS0 20205919 PTHR44500:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG106284|UniProtKB=T1EE14 T1EE14 20194816 PTHR47958:SF215 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX17-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG67129|UniProtKB=T1FYW8 T1FYW8 20214016 PTHR11035:SF3 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 dehydratase#PC00091 HELRO|EnsemblGenome=HelroG66421|UniProtKB=T1FYK9 T1FYK9 20213907 PTHR10896:SF74 GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE P UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;glycoprotein biosynthetic process#GO:0009101;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG191487|UniProtKB=T1FT11 T1FT11 20211958 PTHR35193:SF5 MUCIN 13A, CELL SURFACE-ASSOCIATED-RELATED SEA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176029|UniProtKB=T1FA19 T1FA19 20205668 PTHR24320:SF285 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 14 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG96235|UniProtKB=T1G9A8 T1G9A8 20217655 PTHR11937:SF607 ACTIN ACTIN-42A-RELATED structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;cell division#GO:0051301;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cell cycle#GO:0007049;cytoskeleton-dependent cytokinesis#GO:0061640;cortical actin cytoskeleton organization#GO:0030866;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;cytokinesis#GO:0000910 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG156173|UniProtKB=T1ELS2 T1ELS2 20197522 PTHR21016:SF7 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 3 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of Notch signaling pathway#GO:0045747;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of response to stimulus#GO:0048583 HELRO|EnsemblGenome=HelroG186003|UniProtKB=T1FNJ3 T1FNJ3 20210390 PTHR23428:SF70 HISTONE H2B HISTONE H2B chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG163145|UniProtKB=T1ETQ3 T1ETQ3 20199953 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG183297|UniProtKB=T1FJF5 T1FJF5 20208954 PTHR10697:SF13 MAMMALIAN EPENDYMIN-RELATED PROTEIN 1 RICIN B LECTIN DOMAIN-CONTAINING PROTEIN intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG177109|UniProtKB=T1FB85 T1FB85 20206084 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG97663|UniProtKB=T1G9I4 T1G9I4 20217731 PTHR19965:SF35 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG92478|UniProtKB=T1G8H0 T1G8H0 20217367 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of macromolecule metabolic process#GO:0060255;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;localization#GO:0051179;organelle localization#GO:0051640;localization within membrane#GO:0051668;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;protein localization to nucleus#GO:0034504;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605;nucleus organization#GO:0006997;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;establishment of organelle localization#GO:0051656;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular localization#GO:0051641;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399 HELRO|EnsemblGenome=HelroG71267|UniProtKB=T1G0I6 T1G0I6 20214584 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90252|UniProtKB=T1G7N3 T1G7N3 20217080 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cellular localization#GO:0051641;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;establishment of organelle localization#GO:0051656;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;localization within membrane#GO:0051668;organelle localization#GO:0051640;localization#GO:0051179;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;transport#GO:0006810;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;intracellular protein localization#GO:0008104;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;establishment of localization#GO:0051234;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;membrane organization#GO:0061024;chromatin organization#GO:0006325 nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG173092|UniProtKB=T1F6C0 T1F6C0 20204369 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176701|UniProtKB=T1FAT0 T1FAT0 20205929 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN YEATS DOMAIN-CONTAINING PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178409|UniProtKB=T1FD47 T1FD47 20206746 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68721|UniProtKB=T1FZI8 T1FZI8 20214236 PTHR10285:SF116 URIDINE KINASE URIDINE KINASE cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 Salvage pyrimidine ribonucleotides#P02775>Uridine kinase#P03150;Salvage pyrimidine ribonucleotides#P02775>Cytidine kinase#P03149;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156 HELRO|EnsemblGenome=HelroG179858|UniProtKB=T1FF78 T1FF78 20207477 PTHR22883:SF507 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN ZDHHC-TYPE PALMITOYLTRANSFERASE 7-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83734|UniProtKB=T1G599 T1G599 20216246 PTHR28668:SF1 TRANSMEMBRANE PROTEIN 234 TRANSMEMBRANE PROTEIN 234 HELRO|EnsemblGenome=HelroG105298|UniProtKB=T1EDT5 T1EDT5 20194737 PTHR24390:SF271 ZINC FINGER PROTEIN FI23536P1-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG85712|UniProtKB=T1G621 T1G621 20216518 PTHR11909:SF428 CASEIN KINASE-RELATED DISCS OVERGROWN PROTEIN KINASE-RELATED protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 response to stimulus#GO:0050896;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cellular response to stimulus#GO:0051716;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;cell communication#GO:0007154;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of response to stimulus#GO:0048583 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG113809|UniProtKB=T1EFW9 T1EFW9 20195471 PTHR24006:SF943 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE PUF deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG161228|UniProtKB=T1ER85 T1ER85 20199085 PTHR13850:SF5 PLEIOTROPHIN FAMILY MEMBER PLEIOTROPHIN-A-LIKE intercellular signal molecule#PC00207;growth factor#PC00112 HELRO|EnsemblGenome=HelroG184400|UniProtKB=T1FL45 T1FL45 20209544 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187659|UniProtKB=T1FPB6 T1FPB6 20210663 PTHR13720:SF14 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185073|UniProtKB=T1FMD1 T1FMD1 20209980 PTHR10672:SF44 ADDUCIN PROTEIN HU-LI TAI SHAO actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG162155|UniProtKB=T1ESA4 T1ESA4 20199454 PTHR11009:SF32 DER1-LIKE PROTEIN, DERLIN DERLIN signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;catabolic process#GO:0009056;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG72764|UniProtKB=T1G152 T1G152 20214800 PTHR12820:SF0 VACUOLAR SORTING PROTEIN 53 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166963|UniProtKB=T1EYT5 T1EYT5 20201735 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70335|UniProtKB=T1G050 T1G050 20214448 PTHR19960:SF11 TEKTIN LD08455P cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG186563|UniProtKB=T1FP12 T1FP12 20210559 PTHR31017:SF1 LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG84530|UniProtKB=T1G5J8 T1G5J8 20216345 PTHR46241:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2 HELRO|EnsemblGenome=HelroG106750|UniProtKB=T1EE46 T1EE46 20194848 PTHR48092:SF9 KNIRPS-RELATED PROTEIN-RELATED KNIRPS-RELATED PROTEIN-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG172507|UniProtKB=T1F5F4 T1F5F4 20204053 PTHR13595:SF4 ARL6IP4 PROTEIN CH-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192078|UniProtKB=T1FTK1 T1FTK1 20212148 PTHR48125:SF12 LP07818P1 CONSERVED GLUTAMIC ACID RICH PROTEIN (AFU_ORTHOLOGUE AFUA_5G09010)-RELATED Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525;Huntington disease#P00029>N-Wasp#P00769 HELRO|EnsemblGenome=HelroG175049|UniProtKB=T1F8S3 T1F8S3 20205222 PTHR23050:SF547 CALCIUM BINDING PROTEIN AT10229P-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG185754|UniProtKB=T1FN90 T1FN90 20210288 PTHR24068:SF147 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 K ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG185441|UniProtKB=T1FMU0 T1FMU0 20210139 PTHR23075:SF0 PUTATIVE ATP-ASE ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3A mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG107328|UniProtKB=T1EE96 T1EE96 20194898 PTHR12276:SF115 EPSIN/ENT-RELATED FI19443P1 lipid binding#GO:0008289;protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488;phospholipid binding#GO:0005543 endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810 intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vesicle coat#GO:0030120;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated vesicle#GO:0030136;clathrin vesicle coat#GO:0030125 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG95757|UniProtKB=T1G973 T1G973 20217620 PTHR45625:SF18 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1 catalytic activity, acting on a protein#GO:0140096;cis-trans isomerase activity#GO:0016859;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;catalytic activity#GO:0003824 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 chaperone#PC00072 HELRO|EnsemblGenome=HelroG173977|UniProtKB=T1F7F8 T1F7F8 20204757 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG156123|UniProtKB=T1ELR8 T1ELR8 20197518 PTHR44177:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 8 TETRATRICOPEPTIDE REPEAT PROTEIN 8 cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;BBSome#GO:0034464;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG104231|UniProtKB=T1EDK5 T1EDK5 20194657 PTHR10527:SF6 IMPORTIN BETA IMPORTIN-4 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG185197|UniProtKB=T1FMH8 T1FMH8 20210027 PTHR12489:SF1 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LP10272P membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG82278|UniProtKB=T1G4Q0 T1G4Q0 20216048 PTHR14017:SF32 LYSINE-SPECIFIC DEMETHYLASE LD02225P demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;sequence-specific DNA binding#GO:0043565;histone demethylase activity#GO:0032452;transcription regulatory region nucleic acid binding#GO:0001067;histone modifying activity#GO:0140993;binding#GO:0005488;sequence-specific double-stranded DNA binding#GO:1990837;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;chromatin DNA binding#GO:0031490;DNA binding#GO:0003677;dioxygenase activity#GO:0051213;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG183998|UniProtKB=T1FKE5 T1FKE5 20209294 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;late endosome membrane#GO:0031902;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HELRO|EnsemblGenome=HelroG190762|UniProtKB=T1FS99 T1FS99 20211696 PTHR13800:SF12 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 ION TRANSPORT DOMAIN-CONTAINING PROTEIN ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604 monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG190268|UniProtKB=T1FRU3 T1FRU3 20211540 PTHR23421:SF165 BETA-GALACTOSIDASE RELATED BETA-GALACTOSIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 small molecule catabolic process#GO:0044282;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;carbohydrate catabolic process#GO:0016052;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 hydrolase#PC00121;galactosidase#PC00104 HELRO|EnsemblGenome=HelroG182868|UniProtKB=T1FIW3 T1FIW3 20208762 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192510|UniProtKB=T1FU14 T1FU14 20212310 PTHR45691:SF6 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG80835|UniProtKB=T1G462 T1G462 20215860 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG181548|UniProtKB=T1FH35 T1FH35 20208134 PTHR14865:SF2 CST COMPLEX SUBUNIT CTC1 CST COMPLEX SUBUNIT CTC1 DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697 nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of metabolic process#GO:0009893;regulation of DNA replication#GO:0006275;telomere organization#GO:0032200;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA replication#GO:0045740;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;telomere maintenance via telomere lengthening#GO:0010833;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;telomere maintenance#GO:0000723;chromosome organization#GO:0051276 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;chromosome, telomeric repeat region#GO:0140445;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;nuclear telomere cap complex#GO:0000783;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG176132|UniProtKB=T1FA68 T1FA68 20205717 PTHR24189:SF71 MYOTROPHIN ANKYRIN REPEAT DOMAIN 39 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG180451|UniProtKB=T1FFX9 T1FFX9 20207728 PTHR12515:SF5 STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED PROTEIN SMAUG nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 HELRO|EnsemblGenome=HelroG193047|UniProtKB=T1FUK3 T1FUK3 20212499 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG180324|UniProtKB=T1FFR0 T1FFR0 20207659 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166854|UniProtKB=T1EYM8 T1EYM8 20201678 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71412|UniProtKB=T1G0L2 T1G0L2 20214610 PTHR10442:SF0 40S RIBOSOMAL PROTEIN S21 SMALL RIBOSOMAL SUBUNIT PROTEIN ES21 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;rRNA processing#GO:0006364;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;maturation of 5.8S rRNA#GO:0000460;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG161249|UniProtKB=T1ER93 T1ER93 20199093 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG181489|UniProtKB=T1FH21 T1FH21 20208120 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG125192|UniProtKB=T1EH48 T1EH48 20195898 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;poly(A) binding#GO:0008143;nucleic acid binding#GO:0003676 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG175753|UniProtKB=T1F9M2 T1F9M2 20205521 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG192239|UniProtKB=T1FTR1 T1FTR1 20212208 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG180237|UniProtKB=T1FFL8 T1FFL8 20207617 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG184949|UniProtKB=T1FM73 T1FM73 20209922 PTHR31581:SF2 KICSTOR COMPLEX PROTEIN C12ORF66 KICSTOR SUBUNIT 2 HELRO|EnsemblGenome=HelroG95167|UniProtKB=T1G947 T1G947 20217594 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG156994|UniProtKB=T1EM46 T1EM46 20197646 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 mRNA capping factor#PC00145;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG179272|UniProtKB=T1FEG6 T1FEG6 20207215 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG180341|UniProtKB=T1FFS3 T1FFS3 20207672 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184105|UniProtKB=T1FKL1 T1FKL1 20209360 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG82683|UniProtKB=T1G4V2 T1G4V2 20216100 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG73261|UniProtKB=T1G1C3 T1G1C3 20214871 PTHR23359:SF234 NUCLEOTIDE KINASE ADENYLATE KINASE 2, MITOCHONDRIAL phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside diphosphate metabolic process#GO:0009132;organophosphate biosynthetic process#GO:0090407 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG180768|UniProtKB=T1FG93 T1FG93 20207842 PTHR10627:SF31 SCP160 DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG151400|UniProtKB=T1EKK2 T1EKK2 20197102 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG190234|UniProtKB=T1FRS9 T1FRS9 20211526 PTHR21425:SF3 NICE-3 LIPID TRANSPORT AUXILIARY PROTEIN 1 HELRO|EnsemblGenome=HelroG140634|UniProtKB=T1EJ16 T1EJ16 20196566 PTHR24247:SF222 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 2B, ISOFORM E neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG161839|UniProtKB=T1ERY7 T1ERY7 20199337 PTHR22055:SF0 28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN 28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG73116|UniProtKB=T1G1A4 T1G1A4 20214852 PTHR13229:SF2 PROTEIN KISH-A PROTEIN KISH-A transport#GO:0006810;secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;protein secretion#GO:0009306;establishment of protein localization to extracellular region#GO:0035592;protein transport#GO:0015031;secretion by cell#GO:0032940;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;establishment of protein localization#GO:0045184;export from cell#GO:0140352 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG110051|UniProtKB=T1EEY7 T1EEY7 20195139 PTHR19134:SF570 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG189738|UniProtKB=T1FRB6 T1FRB6 20211363 PTHR10816:SF19 MYELIN TRANSCRIPTION FACTOR 1-RELATED PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG162628|UniProtKB=T1ESX9 T1ESX9 20199679 PTHR24249:SF422 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG160687|UniProtKB=T1EQL6 T1EQL6 20198866 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX ELICITIN PROTEIN RAM2APUTATIVE ELICITIN PROTEIN RAM2BPUTATIVE ELICITIN PROTEIN RAM2C-RELATED transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG163155|UniProtKB=T1ETQ7 T1ETQ7 20199957 PTHR16213:SF79 SELENOPROTEIN N EF-HAND DOMAIN-CONTAINING PROTEIN homeostatic process#GO:0042592;calcium ion homeostasis#GO:0055074;monoatomic ion homeostasis#GO:0050801;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG69777|UniProtKB=T1FZY4 T1FZY4 20214382 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG62927|UniProtKB=T1FX79 T1FX79 20213427 PTHR45892:SF1 AMINOACYLASE-1 AMINOACYLASE-1 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG92598|UniProtKB=T1G8I7 T1G8I7 20217384 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG93842|UniProtKB=T1G8X9 T1G8X9 20217526 PTHR10869:SF244 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2 catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;oxidoreductase complex#GO:1990204 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70936|UniProtKB=T1G0E5 T1G0E5 20214543 PTHR13046:SF0 PROTEASE U48 CAAX PRENYL PROTEASE RCE1 CAAX PRENYL PROTEASE 2 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG156844|UniProtKB=T1EM18 T1EM18 20197618 PTHR10642:SF35 RIBONUCLEASE H1 RIBONUCLEASE H1 RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;RNA catabolic process#GO:0006401;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 mitochondrion#GO:0005739;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG182706|UniProtKB=T1FIM1 T1FIM1 20208670 PTHR11452:SF95 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 metabolic process#GO:0008152;oligosaccharide metabolic process#GO:0009311;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG77714|UniProtKB=T1G329 T1G329 20215477 PTHR10340:SF34 SPHINGOMYELIN PHOSPHODIESTERASE SPHINGOMYELIN PHOSPHODIESTERASE phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;lipase activity#GO:0016298 organophosphate catabolic process#GO:0046434;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;sphingomyelin metabolic process#GO:0006684;lipid biosynthetic process#GO:0008610 intracellular organelle#GO:0043229;extracellular region#GO:0005576;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG165195|UniProtKB=T1EWF0 T1EWF0 20200900 PTHR19303:SF82 TRANSPOSON HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG69165|UniProtKB=T1FZQ3 T1FZQ3 20214301 PTHR11685:SF210 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ARIH2 protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG192354|UniProtKB=T1FTU8 T1FTU8 20212245 PTHR24214:SF38 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;cellular component organization or biogenesis#GO:0071840;anatomical structure development#GO:0048856 organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;actomyosin#GO:0042641;cell-cell junction#GO:0005911;adherens junction#GO:0005912;cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin filament#GO:0005884;cytoskeleton#GO:0005856;stress fiber#GO:0001725 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG189632|UniProtKB=T1FR79 T1FR79 20211326 PTHR45960:SF2 GRB2-ASSOCIATED-BINDING PROTEIN PROTEIN DAUGHTER OF SEVENLESS scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HELRO|EnsemblGenome=HelroG101382|UniProtKB=T1ED43 T1ED43 20194495 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG184293|UniProtKB=T1FKX5 T1FKX5 20209474 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180692|UniProtKB=T1FG64 T1FG64 20207813 PTHR21439:SF0 OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN PROTEIN OSCP1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG77936|UniProtKB=T1G356 T1G356 20215504 PTHR24006:SF887 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG138707|UniProtKB=T1EIW9 T1EIW9 20196519 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of primary metabolic process#GO:0080090;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG176341|UniProtKB=T1FAE7 T1FAE7 20205796 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678 vesicle#GO:0031982;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG194007|UniProtKB=T1FVK3 T1FVK3 20212849 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180894|UniProtKB=T1FGD7 T1FGD7 20207886 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG175185|UniProtKB=T1F8Z2 T1F8Z2 20205291 PTHR46520:SF1 SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;primary metabolic process#GO:0044238;regulation of metabolic process#GO:0019222;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;regulation of lipid metabolic process#GO:0019216 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG75655|UniProtKB=T1G284 T1G284 20215182 PTHR14139:SF2 CALSYNTENIN CALSYNTENIN-1 binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632 regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;cell adhesion#GO:0007155;positive regulation of cellular component organization#GO:0051130;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of synapse assembly#GO:0051963;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of developmental process#GO:0051094;positive regulation of synapse assembly#GO:0051965 postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;cell surface#GO:0009986;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG112029|UniProtKB=T1EFG6 T1EFG6 20195318 PTHR10747:SF38 TRANSCRIPTION FACTOR COE FAMILY MEMBER TRANSCRIPTION FACTOR COLLIER transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 P53-like transcription factor#PC00253;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG62512|UniProtKB=T1FX17 T1FX17 20213365 PTHR10291:SF51 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;primary metabolic process#GO:0044238;isoprenoid metabolic process#GO:0006720;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG168508|UniProtKB=T1F0N2 T1F0N2 20202382 PTHR45665:SF63 AQUAPORIN-8 AQUAPORIN OR AQUAGLYCEROPORIN RELATED-RELATED channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250 fluid transport#GO:0042044;establishment of localization#GO:0051234;water transport#GO:0006833;localization#GO:0051179;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG77575|UniProtKB=T1G300 T1G300 20215448 PTHR15271:SF4 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG78664|UniProtKB=T1G3E3 T1G3E3 20215591 PTHR23505:SF79 SPINSTER PROTEIN SPINSTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG194826|UniProtKB=T1FWG4 T1FWG4 20213159 PTHR46876:SF1 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 HELRO|EnsemblGenome=HelroG187316|UniProtKB=T1FP88 T1FP88 20210635 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM K-RELATED nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG160156|UniProtKB=T1EPW6 T1EPW6 20198616 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184596|UniProtKB=T1FLJ7 T1FLJ7 20209696 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183458|UniProtKB=T1FJP7 T1FJP7 20209046 PTHR15741:SF27 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR AP-4 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG155984|UniProtKB=T1ELQ4 T1ELQ4 20197504 PTHR11599:SF4 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 cytosol#GO:0005829;nucleus#GO:0005634;proteasome complex#GO:0000502;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190839|UniProtKB=T1FSC8 T1FSC8 20211725 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987 postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794;cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG189048|UniProtKB=T1FQL3 T1FQL3 20211110 PTHR23355:SF35 RIBONUCLEASE EXOSOME COMPLEX EXONUCLEASE RRP44 hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nuclear mRNA surveillance#GO:0071028;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981 exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG80086|UniProtKB=T1G3X5 T1G3X5 20215773 PTHR24637:SF422 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113060|UniProtKB=T1EFQ0 T1EFQ0 20195402 PTHR13768:SF8 SOLUBLE NSF ATTACHMENT PROTEIN SNAP ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein-containing complex disassembly#GO:0032984;cellular component organization#GO:0016043;cellular localization#GO:0051641;cellular component disassembly#GO:0022411;localization#GO:0051179;protein transport#GO:0015031;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG125522|UniProtKB=T1EH64 T1EH64 20195914 PTHR12311:SF7 ACTIVATOR OF BASAL TRANSCRIPTION 1 ACTIVATOR OF BASAL TRANSCRIPTION 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;organelle assembly#GO:0070925;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;ribosomal small subunit assembly#GO:0000028;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;maturation of 5.8S rRNA#GO:0000460;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;cellular process#GO:0009987;protein-RNA complex organization#GO:0071826;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HELRO|EnsemblGenome=HelroG159819|UniProtKB=T1EPF9 T1EPF9 20198459 PTHR13621:SF2 PROLINE-RICH PROTEIN PRCC PROLINE-RICH PROTEIN PRCC organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG188000|UniProtKB=T1FPJ2 T1FPJ2 20210739 PTHR14110:SF18 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22 OUTER ENVELOPE PORE PROTEIN 16-3, CHLOROPLASTIC_MITOCHONDRIAL transporter#PC00227 HELRO|EnsemblGenome=HelroG193493|UniProtKB=T1FV18 T1FV18 20212664 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell migration#GO:0016477;cell motility#GO:0048870;regulation of cellular process#GO:0050794;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG114555|UniProtKB=T1EG28 T1EG28 20195530 PTHR24115:SF929 KINESIN-RELATED KINESIN-LIKE PROTEIN AT 31E, ISOFORM A cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG81096|UniProtKB=T1G490 T1G490 20215888 PTHR12504:SF0 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG protein transport#GO:0015031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;protein localization to mitochondrion#GO:0070585;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial outer membrane translocase complex#GO:0005742;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG106017|UniProtKB=T1EDZ2 T1EDZ2 20194794 PTHR45639:SF4 HSC70CB, ISOFORM G-RELATED HSC70CB, ISOFORM G nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072;Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG177999|UniProtKB=T1FCL0 T1FCL0 20206559 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72466|UniProtKB=T1G105 T1G105 20214753 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 heterochromatin formation#GO:0031507;nuclear migration#GO:0007097;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of macromolecule metabolic process#GO:0060255;organelle localization#GO:0051640;localization within membrane#GO:0051668;localization#GO:0051179;protein localization to nucleus#GO:0034504;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;chromatin organization#GO:0006325;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;establishment of localization#GO:0051234;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular localization#GO:0051641;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840 nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear lumen#GO:0031981;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG188986|UniProtKB=T1FQJ1 T1FQJ1 20211088 PTHR12800:SF4 CDC37-RELATED HSP90 CO-CHAPERONE CDC37 heat shock protein binding#GO:0031072;binding#GO:0005488;protein binding#GO:0005515 protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;biological regulation#GO:0065007;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of protein stability#GO:0031647;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821;metabolic process#GO:0008152 protein folding chaperone complex#GO:0101031;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535 chaperone#PC00072 HELRO|EnsemblGenome=HelroG170101|UniProtKB=T1F2M5 T1F2M5 20203074 PTHR15082:SF2 NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3 respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG166769|UniProtKB=T1EYI1 T1EYI1 20201631 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180659|UniProtKB=T1FG49 T1FG49 20207798 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG177435|UniProtKB=T1FBP6 T1FBP6 20206245 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189214|UniProtKB=T1FQS9 T1FQS9 20211176 PTHR10098:SF108 RAPSYN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 28 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180380|UniProtKB=T1FFV0 T1FFV0 20207699 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG194324|UniProtKB=T1FVX7 T1FVX7 20212973 PTHR19316:SF35 PROTEIN FOLDING REGULATOR NUCLEOTIDE EXCHANGE FACTOR SIL1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG171479|UniProtKB=T1F4C4 T1F4C4 20203673 PTHR34718:SF3 PHD-TYPE DOMAIN-CONTAINING PROTEIN UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89658|UniProtKB=T1G7F6 T1G7F6 20217003 PTHR16318:SF1 GAMMA-SECRETASE SUBUNIT PEN-2 GAMMA-SECRETASE SUBUNIT PEN-2 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 catalytic complex#GO:1902494;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 Alzheimer disease-amyloid secretase pathway#P00003>Pen-2#P00089;Alzheimer disease-presenilin pathway#P00004>Pen-2#P00149 HELRO|EnsemblGenome=HelroG83856|UniProtKB=T1G5B1 T1G5B1 20216258 PTHR31859:SF9 TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER TETRATRICOPEPTIDE REPEAT PROTEIN TTC-39B HELRO|EnsemblGenome=HelroG77890|UniProtKB=T1G352 T1G352 20215500 PTHR11802:SF472 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE SERINE CARBOXYPEPTIDASE CPVL-RELATED hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;serine hydrolase activity#GO:0017171;carboxypeptidase activity#GO:0004180;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 serine protease#PC00203 HELRO|EnsemblGenome=HelroG189697|UniProtKB=T1FR97 T1FR97 20211344 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG86883|UniProtKB=T1G6I8 T1G6I8 20216685 PTHR20863:SF80 ACYL CARRIER PROTEIN ACYL CARRIER PROTEIN, MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG171496|UniProtKB=T1F4C8 T1F4C8 20203677 PTHR44298:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 11 DNAJ HOMOLOG SUBFAMILY B MEMBER 11 binding#GO:0005488;protein binding#GO:0005515 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG174433|UniProtKB=T1F843 T1F843 20204992 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG64550|UniProtKB=T1FXW3 T1FXW3 20213661 PTHR18860:SF176 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON binding#GO:0005488;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624 HELRO|EnsemblGenome=HelroG186146|UniProtKB=T1FNQ5 T1FNQ5 20210452 PTHR12317:SF0 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG155722|UniProtKB=T1ELL5 T1ELL5 20197465 PTHR10556:SF28 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE VERY-LONG-CHAIN ENOYL-COA REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG101607|UniProtKB=T1ED57 T1ED57 20194509 PTHR11202:SF38 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;system development#GO:0048731;supramolecular fiber organization#GO:0097435;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon guidance#GO:0007411;axon development#GO:0061564;actin polymerization or depolymerization#GO:0008154;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036 intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cell periphery#GO:0071944;membrane#GO:0016020;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;filopodium#GO:0030175 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG96859|UniProtKB=T1G9D9 T1G9D9 20217686 PTHR13090:SF1 ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG176895|UniProtKB=T1FB12 T1FB12 20206011 PTHR24365:SF530 TOLL-LIKE RECEPTOR TOLL-9, ISOFORM A molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG115704|UniProtKB=T1EGA1 T1EGA1 20195603 PTHR11909:SF428 CASEIN KINASE-RELATED DISCS OVERGROWN PROTEIN KINASE-RELATED protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG138705|UniProtKB=T1EIW7 T1EIW7 20196517 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;plasma membrane bounded cell projection organization#GO:0120036;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;sensory organ development#GO:0007423;developmental process#GO:0032502;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG184901|UniProtKB=T1FM53 T1FM53 20209902 PTHR16222:SF44 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG175963|UniProtKB=T1F9Z2 T1F9Z2 20206289 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG168787|UniProtKB=T1F0Z0 T1F0Z0 20202490 PTHR24274:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929 structural protein#PC00211 HELRO|EnsemblGenome=HelroG146924|UniProtKB=T1EJV6 T1EJV6 20196856 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66965|UniProtKB=T1FYU0 T1FYU0 20213988 PTHR15852:SF54 PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN PROTEIN SSUH2 HOMOLOG HELRO|EnsemblGenome=HelroG176491|UniProtKB=T1FAK7 T1FAK7 20205856 PTHR43788:SF20 DNA2/NAM7 HELICASE FAMILY MEMBER DNA-BINDING PROTEIN SMUBP-2 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stress#GO:0006950 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG193018|UniProtKB=T1FUI9 T1FUI9 20212485 PTHR21716:SF4 TRANSMEMBRANE PROTEIN TRANSMEMBRANE PROTEIN 245 cellular process#GO:0009987;transport#GO:0006810;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG192533|UniProtKB=T1FU22 T1FU22 20212318 PTHR12656:SF14 BRG-1 ASSOCIATED FACTOR 250 BAF250 TRITHORAX GROUP PROTEIN OSA binding#GO:0005488;chromatin binding#GO:0003682;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877 regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;ATPase complex#GO:1904949 HELRO|EnsemblGenome=HelroG176731|UniProtKB=T1FAU6 T1FAU6 20205945 PTHR12346:SF71 SIN3B-RELATED PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>Sin3A#P00771 HELRO|EnsemblGenome=HelroG71078|UniProtKB=T1G0G5 T1G0G5 20214563 PTHR10969:SF33 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN enzyme binding#GO:0019899;binding#GO:0005488;signaling receptor binding#GO:0005102;lipid binding#GO:0008289;protein binding#GO:0005515;ubiquitin-like protein ligase binding#GO:0044389;GABA receptor binding#GO:0050811;phospholipid binding#GO:0005543;ubiquitin protein ligase binding#GO:0031625 cellular component organization#GO:0016043;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;response to nutrient levels#GO:0031667;organelle organization#GO:0006996;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;cellular response to starvation#GO:0009267;metabolic process#GO:0008152;cellular response to nutrient levels#GO:0031669;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045 intracellular organelle#GO:0043229;autophagosome#GO:0005776;autophagosome membrane#GO:0000421;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG176474|UniProtKB=T1FAJ6 T1FAJ6 20205845 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG88096|UniProtKB=T1G6Y5 T1G6Y5 20216832 PTHR21646:SF114 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG72710|UniProtKB=T1G142 T1G142 20214790 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG141216|UniProtKB=T1EJ31 T1EJ31 20196581 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING IP01257P-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG184019|UniProtKB=T1FKF7 T1FKF7 20209306 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG115575|UniProtKB=T1EG94 T1EG94 20195596 PTHR10666:SF438 UBIQUITIN UBIQUITIN-RIBOSOMAL PROTEIN ES31 FUSION PROTEIN structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;nucleus#GO:0005634;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG182059|UniProtKB=T1FHP1 T1FHP1 20208340 PTHR19282:SF456 TETRASPANIN FI23944P1-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189337|UniProtKB=T1FQZ3 T1FQZ3 20211240 PTHR13058:SF19 THREE PRIME REPAIR EXONUCLEASE 1, 2 LD40940P 3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA catabolic process#GO:0006308;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91562|UniProtKB=T1G855 T1G855 20217252 PTHR44490:SF1 EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209;enzyme activator activity#GO:0008047 positive regulation of apoptotic process#GO:0043065;regulation of response to stress#GO:0080134;positive regulation of intracellular signal transduction#GO:1902533;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 translation elongation factor#PC00222;translation factor#PC00223 HELRO|EnsemblGenome=HelroG111475|UniProtKB=T1EFB6 T1EFB6 20195268 PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE hydrolase activity#GO:0016787;triacylglycerol lipase activity#GO:0004806;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 glycerolipid catabolic process#GO:0046503;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;triglyceride catabolic process#GO:0019433;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HELRO|EnsemblGenome=HelroG107165|UniProtKB=T1EE83 T1EE83 20194885 PTHR12706:SF30 STRAWBERRY NOTCH-RELATED PROTEIN STRAWBERRY NOTCH-RELATED HELRO|EnsemblGenome=HelroG182662|UniProtKB=T1FIJ9 T1FIJ9 20208648 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG158602|UniProtKB=T1EN04 T1EN04 20197954 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183600|UniProtKB=T1FJW8 T1FJW8 20209117 PTHR24075:SF5 SEC63 DOMAIN-CONTAINING U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168144|UniProtKB=T1F079 T1F079 20202229 PTHR11474:SF139 TYROSINASE FAMILY MEMBER TYROSINASE-LIKE PROTEIN TYR-1-RELATED oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG177753|UniProtKB=T1FC71 T1FC71 20206420 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184897|UniProtKB=T1FM50 T1FM50 20209899 PTHR10333:SF113 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 5 protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG176718|UniProtKB=T1FAT7 T1FAT7 20205936 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG185750|UniProtKB=T1FN87 T1FN87 20210285 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 ligase#PC00142 HELRO|EnsemblGenome=HelroG135179|UniProtKB=T1EI71 T1EI71 20196271 PTHR15698:SF4 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG170801|UniProtKB=T1F3G0 T1F3G0 20203359 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188352|UniProtKB=T1FPW8 T1FPW8 20210865 PTHR13817:SF170 TITIN SUBFAMILY NOT NAMED structural protein#PC00211 HELRO|EnsemblGenome=HelroG187454|UniProtKB=T1FP99 T1FP99 20210646 PTHR18937:SF12 STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;chromosome organization#GO:0051276;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cohesin complex#GO:0008278;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157626|UniProtKB=T1EME1 T1EME1 20197741 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;U4/U6 x U5 tri-snRNP complex#GO:0046540;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG182878|UniProtKB=T1FIW4 T1FIW4 20208763 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178681|UniProtKB=T1FDK3 T1FDK3 20206902 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions#GO:0000375;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA biosynthetic process#GO:0032774;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mRNA processing#GO:0006397;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG193596|UniProtKB=T1FV57 T1FV57 20212703 PTHR10131:SF153 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 3 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular process#GO:0009987 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162325|UniProtKB=T1ESI2 T1ESI2 20199532 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG104783|UniProtKB=T1EDN6 T1EDN6 20194688 PTHR24390:SF245 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG82844|UniProtKB=T1G4X2 T1G4X2 20216120 PTHR19229:SF278 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 localization#GO:0051179;lipid transport#GO:0006869;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG176891|UniProtKB=T1FB09 T1FB09 20206008 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63046|UniProtKB=T1FXA3 T1FXA3 20213451 PTHR45445:SF2 FAMILY NOT NAMED METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171372|UniProtKB=T1F471 T1F471 20203620 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;snRNA transcription#GO:0009301;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG94198|UniProtKB=T1G8Z3 T1G8Z3 20217540 PTHR10571:SF0 UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG79877|UniProtKB=T1G3U7 T1G3U7 20215745 PTHR22798:SF0 MCT-1 PROTEIN MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1 translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational initiation#GO:0006413;translation#GO:0006412;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG172527|UniProtKB=T1F5G7 T1F5G7 20204066 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG190022|UniProtKB=T1FRL7 T1FRL7 20211464 PTHR42757:SF48 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG181415|UniProtKB=T1FGZ3 T1FGZ3 20208092 PTHR45011:SF1 DAP3-BINDING CELL DEATH ENHANCER 1 DAP3-BINDING CELL DEATH ENHANCER 1 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stress#GO:0006950;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62239|UniProtKB=T1FWX7 T1FWX7 20213325 PTHR10969:SF4 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289 response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;cellular response to starvation#GO:0009267;metabolic process#GO:0008152;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;cellular response to nutrient levels#GO:0031669;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;response to starvation#GO:0042594;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;cellular component disassembly#GO:0022411;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919 membrane#GO:0016020;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;autophagosome#GO:0005776;intracellular organelle#GO:0043229;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG86249|UniProtKB=T1G692 T1G692 20216589 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG98295|UniProtKB=T1G9L9 T1G9L9 20217765 PTHR15929:SF0 STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR regulation of biological process#GO:0050789;regulation of calcium ion transport#GO:0051924;regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of transport#GO:0051049;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HELRO|EnsemblGenome=HelroG193046|UniProtKB=T1FUK2 T1FUK2 20212498 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG186049|UniProtKB=T1FNL5 T1FNL5 20210412 PTHR13093:SF0 ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1 ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 1 protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;chromatin binding#GO:0003682;binding#GO:0005488 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;Swr1 complex#GO:0000812;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG160668|UniProtKB=T1EQK9 T1EQK9 20198859 PTHR31551:SF1 PRE-MRNA-SPLICING FACTOR CWF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 12 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG158419|UniProtKB=T1EMR7 T1EMR7 20197867 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160033|UniProtKB=T1EPP4 T1EPP4 20198544 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG84823|UniProtKB=T1G5P2 T1G5P2 20216389 PTHR11011:SF129 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG67931|UniProtKB=T1FZ80 T1FZ80 20214128 PTHR31184:SF2 HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER HUNTINGTIN-INTERACTING PROTEIN K biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;regulation of protein stability#GO:0031647;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 HELRO|EnsemblGenome=HelroG170789|UniProtKB=T1F3F3 T1F3F3 20203352 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG164378|UniProtKB=T1EVC6 T1EVC6 20200526 PTHR31508:SF2 PROTEIN PITCHFORK CILIARY MICROTUBULE-ASSOCIATED PROTEIN 3 protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;regulation of cell projection organization#GO:0031344;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG86767|UniProtKB=T1G6G8 T1G6G8 20216665 PTHR19818:SF163 ZINC FINGER PROTEIN ZIC AND GLI FEZ FAMILY ZINC FINGER PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG108795|UniProtKB=T1EEM5 T1EEM5 20195027 PTHR24342:SF12 SERINE/THREONINE-PROTEIN KINASE 17 DEATH-ASSOCIATED PROTEIN KINASE RELATED protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG113569|UniProtKB=T1EFT8 T1EFT8 20195440 PTHR11685:SF371 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF14 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG170702|UniProtKB=T1F3C0 T1F3C0 20203319 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG110615|UniProtKB=T1EF36 T1EF36 20195188 PTHR23042:SF76 CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG68810|UniProtKB=T1FZJ7 T1FZJ7 20214245 PTHR45628:SF40 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267 calcium ion transmembrane transport#GO:0070588;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;calcium ion import#GO:0070509;anterograde trans-synaptic signaling#GO:0098916;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;signaling#GO:0023052;inorganic ion import across plasma membrane#GO:0099587;trans-synaptic signaling#GO:0099537;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;synaptic signaling#GO:0099536;cellular process#GO:0009987;cell-cell signaling#GO:0007267;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022 HELRO|EnsemblGenome=HelroG167418|UniProtKB=T1EZC2 T1EZC2 20201922 PTHR24027:SF452 CADHERIN-23 NEURAL-CADHERIN 2-RELATED beta-catenin binding#GO:0008013;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;cell motility#GO:0048870;cell migration#GO:0016477 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG180592|UniProtKB=T1FG27 T1FG27 20207776 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG182816|UniProtKB=T1FIS8 T1FIS8 20208727 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG84384|UniProtKB=T1G5I2 T1G5I2 20216329 PTHR11537:SF105 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;cellular process#GO:0009987;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;action potential#GO:0001508 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG113955|UniProtKB=T1EFX6 T1EFX6 20195478 PTHR11792:SF17 ARRESTIN KURTZ ARRESTIN G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;transport#GO:0006810;regulation of response to stimulus#GO:0048583;establishment of localization#GO:0051234;import into cell#GO:0098657;system process#GO:0003008;receptor-mediated endocytosis#GO:0006898;receptor internalization#GO:0031623;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;sensory perception#GO:0007600;nervous system process#GO:0050877;regulation of signaling#GO:0023051;localization#GO:0051179;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>beta-arrestin#P00880;Wnt signaling pathway#P00057>beta-arrestin#P01456;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>beta-arrestin#P00723 HELRO|EnsemblGenome=HelroG191441|UniProtKB=T1FSZ7 T1FSZ7 20211944 PTHR46621:SF1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;snRNA transcription by RNA polymerase II#GO:0042795;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;snRNA transcription#GO:0009301;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;snRNA transcription by RNA polymerase III#GO:0042796;RNA metabolic process#GO:0016070 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 HELRO|EnsemblGenome=HelroG101408|UniProtKB=T1ED45 T1ED45 20194497 PTHR10527:SF1 IMPORTIN BETA IMPORTIN SUBUNIT BETA-1 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HELRO|EnsemblGenome=HelroG130656|UniProtKB=T1EHU4 T1EHU4 20196144 PTHR11814:SF282 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 chloride transport#GO:0006821;transport#GO:0006810;chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG106217|UniProtKB=T1EE09 T1EE09 20194811 PTHR12811:SF3 VACUOLAR PROTEIN SORTING VPS16 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;vacuole fusion, non-autophagic#GO:0042144;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vacuole organization#GO:0007033;cellular localization#GO:0051641;localization#GO:0051179;vacuole fusion#GO:0097576;cellular component organization#GO:0016043 vesicle tethering complex#GO:0099023;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;lysosomal membrane#GO:0005765;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;lysosome#GO:0005764;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG67618|UniProtKB=T1FZ30 T1FZ30 20214078 PTHR24223:SF465 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG179275|UniProtKB=T1FEG8 T1FEG8 20207217 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157064|UniProtKB=T1EM58 T1EM58 20197658 PTHR12128:SF74 DIHYDRODIPICOLINATE SYNTHASE 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL lyase activity#GO:0016829;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 glyoxylate metabolic process#GO:0046487;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;aldehyde catabolic process#GO:0046185;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 lyase#PC00144 HELRO|EnsemblGenome=HelroG172421|UniProtKB=T1F5B0 T1F5B0 20204009 PTHR47705:SF1 AGAP000321-PA WINGED HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188365|UniProtKB=T1FPX4 T1FPX4 20210871 PTHR10316:SF40 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED LD27118P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;cell communication#GO:0007154 cell-cell junction#GO:0005911;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cell junction#GO:0030054;adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115498|UniProtKB=T1EG86 T1EG86 20195588 PTHR45820:SF10 FI23527P1 ZINC TRANSPORTER 63C, ISOFORM F transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;response to chemical#GO:0042221;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;detoxification#GO:0098754;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;response to metal ion#GO:0010038;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;homeostatic process#GO:0042592;metal ion transport#GO:0030001;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185831|UniProtKB=T1FNC5 T1FNC5 20210322 PTHR15350:SF2 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG194218|UniProtKB=T1FVT6 T1FVT6 20212932 PTHR23404:SF3 MOLYBDOPTERIN SYNTHASE RELATED MAP3K12-BINDING INHIBITORY PROTEIN 1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG86965|UniProtKB=T1G6K0 T1G6K0 20216697 PTHR11679:SF85 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33A vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;lytic vacuole#GO:0000323 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG108152|UniProtKB=T1EEG0 T1EEG0 20194962 PTHR31661:SF1 SIMILAR TO CDNA SEQUENCE BC052040 CDAN1-INTERACTING NUCLEASE 1 HELRO|EnsemblGenome=HelroG189095|UniProtKB=T1FQM7 T1FQM7 20211124 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG160790|UniProtKB=T1EQQ4 T1EQQ4 20198904 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG158911|UniProtKB=T1ENE2 T1ENE2 20198092 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185103|UniProtKB=T1FME4 T1FME4 20209993 PTHR47385:SF14 CALPONIN TRANSGELIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG163097|UniProtKB=T1ETN2 T1ETN2 20199932 PTHR15577:SF2 ZINC FINGER CONTAINING PROTEIN ZINC FINGER PROTEIN 318 positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG191982|UniProtKB=T1FTH4 T1FTH4 20212121 PTHR12607:SF12 ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY ADENOMATOUS POLYPOSIS COLI PROTEIN-LIKE ISOFORM X1 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 regulation of microtubule-based process#GO:0032886;pattern specification process#GO:0007389;negative regulation of cytoskeleton organization#GO:0051494;anatomical structure development#GO:0048856;negative regulation of protein-containing complex disassembly#GO:0043242;system development#GO:0048731;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein depolymerization#GO:1901879;cell migration#GO:0016477;negative regulation of Wnt signaling pathway#GO:0030178;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of protein depolymerization#GO:1901880;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;cell fate commitment#GO:0045165;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;regulation of Wnt signaling pathway#GO:0030111;cell fate specification#GO:0001708;multicellular organism development#GO:0007275;regulation of protein-containing complex disassembly#GO:0043244;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of signal transduction#GO:0009968 microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;cytoplasmic microtubule#GO:0005881;plasma membrane protein complex#GO:0098797;extrinsic component of membrane#GO:0019898;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;extrinsic component of plasma membrane#GO:0019897;intracellular protein-containing complex#GO:0140535;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG188883|UniProtKB=T1FQF6 T1FQF6 20211053 PTHR14894:SF0 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 biological regulation#GO:0065007;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;signal transduction#GO:0007165;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of cell cycle#GO:0051726;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG172909|UniProtKB=T1F643 T1F643 20204292 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG162854|UniProtKB=T1ETA2 T1ETA2 20199802 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76005|UniProtKB=T1G2D9 T1G2D9 20215237 PTHR46473:SF23 GH08155P GH08155P HELRO|EnsemblGenome=HelroG191274|UniProtKB=T1FSU0 T1FSU0 20211887 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG81386|UniProtKB=T1G4D9 T1G4D9 20215937 PTHR46917:SF1 MORN REPEAT-CONTAINING PROTEIN 2 MORN REPEAT-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG164230|UniProtKB=T1EV50 T1EV50 20200450 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169800|UniProtKB=T1F2C0 T1F2C0 20202970 PTHR46593:SF2 TRANSMEMBRANE PROTEIN 64 LD47277P intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG182128|UniProtKB=T1FHT1 T1FHT1 20208380 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158328|UniProtKB=T1EMN8 T1EMN8 20197838 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159927|UniProtKB=T1EPK4 T1EPK4 20198504 PTHR11003:SF360 POTASSIUM CHANNEL, SUBFAMILY K IP11374P transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185803|UniProtKB=T1FNB2 T1FNB2 20210309 PTHR11349:SF116 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE B transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550 nucleoside triphosphate metabolic process#GO:0009141;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleoside triphosphate biosynthetic process#GO:0009142;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;kinase#PC00137 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156;De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912 HELRO|EnsemblGenome=HelroG175974|UniProtKB=T1F9Z5 T1F9Z5 20205644 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179278|UniProtKB=T1FEH0 T1FEH0 20207219 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG123334|UniProtKB=T1EGX6 T1EGX6 20195826 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185799|UniProtKB=T1FNA8 T1FNA8 20210305 PTHR47992:SF257 PROTEIN PHOSPHATASE ALPHABET, ISOFORM E phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787 negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of intracellular signal transduction#GO:1902532;regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 DPP signaling pathway#P06213>PPM1A#P06289;Activin beta signaling pathway#P06210>PPM1A#P06237;MYO signaling pathway#P06215>PPM1A#P06317;SCW signaling pathway#P06216>PPM1A#P06332;BMP/activin signaling pathway-drosophila#P06211>PPM1A#P06247;GBB signaling pathway#P06214>PPM1A#P06296;ALP23B signaling pathway#P06209>PPM1A#P06226;DPP-SCW signaling pathway#P06212>PPM1A#P06261 HELRO|EnsemblGenome=HelroG93421|UniProtKB=T1G8V7 T1G8V7 20217504 PTHR11829:SF380 FORKHEAD BOX PROTEIN PROTEIN FORK HEAD double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG175224|UniProtKB=T1F914 T1F914 20205313 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN protein binding#GO:0005515;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 synaptic signaling#GO:0099536;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;nervous system development#GO:0007399;multicellular organism development#GO:0007275;protein localization to synapse#GO:0035418;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;cell adhesion#GO:0007155;receptor clustering#GO:0043113;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;macromolecule localization#GO:0033036;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;developmental process#GO:0032502;intracellular protein localization#GO:0008104;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;anatomical structure development#GO:0048856;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731 synaptic membrane#GO:0097060;cell junction#GO:0030054;neuromuscular junction#GO:0031594;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179527|UniProtKB=T1FEU6 T1FEU6 20207345 PTHR23301:SF0 CHITIN BINDING PERITROPHIN-A CHITINASE HELRO|EnsemblGenome=HelroG82198|UniProtKB=T1G4P1 T1G4P1 20216039 PTHR10913:SF45 FOLLISTATIN-RELATED AGRIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG109229|UniProtKB=T1EER7 T1EER7 20195069 PTHR12083:SF9 BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773;nucleobase-containing compound kinase activity#GO:0019205;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 nucleotide phosphatase#PC00173;phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185675|UniProtKB=O18467 O18467 20210246 PTHR12887:SF11 NANOS PROTEIN PROTEIN NANOS mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;negative regulation of macromolecule metabolic process#GO:0010605;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;negative regulation of protein metabolic process#GO:0051248;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;oogenesis#GO:0048477;negative regulation of translation#GO:0017148;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell differentiation#GO:0030154;gamete generation#GO:0007276 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG73175|UniProtKB=T1G1B2 T1G1B2 20214860 PTHR10851:SF0 PYRIDOXINE-5-PHOSPHATE OXIDASE PYRIDOXINE-5'-PHOSPHATE OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;small molecule biosynthetic process#GO:0044283;pyridine-containing compound metabolic process#GO:0072524;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidase#PC00175;oxidoreductase#PC00176 Vitamin B6 metabolism#P02787>Pyridoxamine phosphate oxidase#P03236;Pyridoxal phosphate salvage pathway#P02770>Pyridoxamine-5-phosphate oxidase#P03120;Pyridoxal phosphate salvage pathway#P02770>Pyridoxine-5-phosphate oxidase#P03123;Pyridoxal-5-phosphate biosynthesis#P02759>Pyridoxine-5-phosphate oxidase#P03061 HELRO|EnsemblGenome=HelroG74950|UniProtKB=T1G1Y3 T1G1Y3 20215081 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085 protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG189815|UniProtKB=T1FRE1 T1FRE1 20211388 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG65151|UniProtKB=T1FY37 T1FY37 20213735 PTHR43442:SF3 GLUCONOKINASE-RELATED GLUCONOKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;oxoacid metabolic process#GO:0043436;pentose-phosphate shunt#GO:0006098;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;nucleobase-containing small molecule metabolic process#GO:0055086;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152 kinase#PC00137 HELRO|EnsemblGenome=HelroG88263|UniProtKB=T1G710 T1G710 20216857 PTHR33963:SF2 MKRN2 OPPOSITE STRAND PROTEIN MKRN2 OPPOSITE STRAND PROTEIN HELRO|EnsemblGenome=HelroG173804|UniProtKB=T1F789 T1F789 20204688 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185250|UniProtKB=T1FMK1 T1FMK1 20210050 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272 transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185618|UniProtKB=T1FN18 T1FN18 20210217 PTHR24256:SF576 TRYPTASE-RELATED IP10114P-RELATED hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG145767|UniProtKB=T1EJM8 T1EJM8 20196778 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN hormone binding#GO:0042562;binding#GO:0005488;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG78607|UniProtKB=T1G3D7 T1G3D7 20215585 PTHR12768:SF4 BECLIN 1 BECLIN-1 protein binding#GO:0005515;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;phosphatidylinositol 3-kinase binding#GO:0043548 process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;cellular response to stress#GO:0033554;late endosome to vacuole transport#GO:0045324;response to stimulus#GO:0050896;cellular component organization#GO:0016043;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;vacuole organization#GO:0007033;localization#GO:0051179;organelle assembly#GO:0070925;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;mitophagy#GO:0000423;establishment of localization#GO:0051234;cellular response to nutrient levels#GO:0031669;vacuolar transport#GO:0007034;transport#GO:0006810;cellular response to starvation#GO:0009267;intracellular transport#GO:0046907;autophagy of mitochondrion#GO:0000422;macroautophagy#GO:0016236;response to nutrient levels#GO:0031667 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;catalytic complex#GO:1902494;transferase complex#GO:1990234;phagophore assembly site#GO:0000407;phosphatidylinositol 3-kinase complex, class III#GO:0035032;transferase complex, transferring phosphorus-containing groups#GO:0061695 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG190875|UniProtKB=T1FSD7 T1FSD7 20211734 PTHR44675:SF1 PAK1 INTERACTING PROTEIN 1 P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857 ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG168360|UniProtKB=T1F0G9 T1F0G9 20202319 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG88449|UniProtKB=T1G727 T1G727 20216874 PTHR24044:SF417 NOTCH LIGAND FAMILY MEMBER WEARY, ISOFORM B protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG192221|UniProtKB=T1FTQ4 T1FTQ4 20212201 PTHR13288:SF9 SPLICING FACTOR 45 SPF45 SPLICING FACTOR 45 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;alternative mRNA splicing, via spliceosome#GO:0000380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG74887|UniProtKB=T1G1X3 T1G1X3 20215071 PTHR24340:SF111 HOMEOBOX PROTEIN NKX TRANSCRIPTION FACTOR PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG89568|UniProtKB=T1G7E3 T1G7E3 20216990 PTHR45725:SF22 FORMIN HOMOLOGY 2 FAMILY MEMBER DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG183936|UniProtKB=T1FKB6 T1FKB6 20209265 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 vesicle#GO:0031982;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG188814|UniProtKB=T1FQE2 T1FQE2 20211039 PTHR15672:SF8 CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN PROTEIN ENCORE HELRO|EnsemblGenome=HelroG178171|UniProtKB=T1FCV8 T1FCV8 20206657 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176723|UniProtKB=T1FAU1 T1FAU1 20205940 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70524|UniProtKB=T1G076 T1G076 20214474 PTHR24208:SF105 LIM/HOMEOBOX PROTEIN LHX DLIM1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG194058|UniProtKB=T1FVM6 T1FVM6 20212872 PTHR24006:SF733 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12_46 HOMOLOG hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG65292|UniProtKB=T1FY55 T1FY55 20213753 PTHR14741:SF32 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED TRIMETHYLGUANOSINE SYNTHASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173 methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG88883|UniProtKB=T1G772 T1G772 20216919 PTHR45722:SF2 60S RIBOSOMAL PROTEIN L35 LARGE RIBOSOMAL SUBUNIT PROTEIN UL29 RNA binding#GO:0003723;structural molecule activity#GO:0005198;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;binding#GO:0005488;mRNA binding#GO:0003729 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG137415|UniProtKB=T1EIK6 T1EIK6 20196406 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180178|UniProtKB=T1FFJ6 T1FFJ6 20207595 PTHR20661:SF0 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN GLUCOSAMINYL-PHOSPHATIDYLINOSITOL-ACYLTRANSFERASE PIGW acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 carbohydrate derivative metabolic process#GO:1901135;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG155421|UniProtKB=T1ELI3 T1ELI3 20197433 PTHR13505:SF7 TRANSMEMBRANE PROTEIN 208 TRANSMEMBRANE PROTEIN 208 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG108298|UniProtKB=T1EEI1 T1EEI1 20194983 PTHR12250:SF0 PHOSPHATIDYLINOSITOL GLYCAN, CLASS N GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1 phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;organophosphate metabolic process#GO:0019637;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;carbohydrate derivative metabolic process#GO:1901135;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG159014|UniProtKB=T1ENH5 T1ENH5 20198125 PTHR37018:SF1 CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED HELRO|EnsemblGenome=HelroG66622|UniProtKB=T1FYN2 T1FYN2 20213930 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN 7, ISOFORM A molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515;phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149 localization#GO:0051179;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of cellular process#GO:0050794;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of localization#GO:0032879;regulation of transport#GO:0051049;vesicle organization#GO:0016050;transport#GO:0006810;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;biological regulation#GO:0065007;organelle membrane fusion#GO:0090174;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular process#GO:0009987 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG85220|UniProtKB=T1G5U4 T1G5U4 20216441 PTHR12740:SF4 JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87901|UniProtKB=T1G6W4 T1G6W4 20216811 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of transport#GO:0051049;regulation of localization#GO:0032879;intracellular protein localization#GO:0008104;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;macromolecule localization#GO:0033036;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of neurotransmitter secretion#GO:0046928;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of biological process#GO:0050789 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;anchoring junction#GO:0070161;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG174473|UniProtKB=T1F858 T1F858 20205007 PTHR11905:SF247 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG165675|UniProtKB=T1EX56 T1EX56 20201156 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190335|UniProtKB=T1FRX0 T1FRX0 20211567 PTHR43358:SF4 ALPHA/BETA-HYDROLASE ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG163010|UniProtKB=T1ETK1 T1ETK1 20199901 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG170905|UniProtKB=T1F3K9 T1F3K9 20203408 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG193880|UniProtKB=T1FVF8 T1FVF8 20212804 PTHR12802:SF184 SWI/SNF COMPLEX-RELATED BRAHMA ASSOCIATED PROTEIN 155 KDA binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG91227|UniProtKB=T1G812 T1G812 20217209 PTHR10741:SF5 TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X TRANSLIN-ASSOCIATED PROTEIN X nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;nuclease activity#GO:0004518;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG136179|UniProtKB=T1EIC4 T1EIC4 20196324 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG80374|UniProtKB=T1G400 T1G400 20215798 PTHR45636:SF58 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-6 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;sensory organ development#GO:0007423;head development#GO:0060322;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG182184|UniProtKB=T1FHW2 T1FHW2 20208411 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194758|UniProtKB=T1FWD6 T1FWD6 20213131 PTHR11689:SF169 CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER H(+)_CL(-) EXCHANGE TRANSPORTER 7 passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;chloride channel activity#GO:0005254;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 chloride transmembrane transport#GO:1902476;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;vesicle#GO:0031982;lysosome#GO:0005764;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;monoatomic ion channel complex#GO:0034702;late endosome#GO:0005770;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 ion channel#PC00133 HELRO|EnsemblGenome=HelroG192080|UniProtKB=T1FTK2 T1FTK2 20212149 PTHR24034:SF205 EGF-LIKE DOMAIN-CONTAINING PROTEIN PAWN, ISOFORM B extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG83641|UniProtKB=T1G585 T1G585 20216232 PTHR31849:SF1 CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1 CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG189687|UniProtKB=T1FR93 T1FR93 20211340 PTHR24388:SF53 ZINC FINGER PROTEIN AT-RICH BINDING PROTEIN-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG180128|UniProtKB=T1FFH9 T1FFH9 20207578 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193911|UniProtKB=T1FVG9 T1FVG9 20212815 PTHR46785:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B HELRO|EnsemblGenome=HelroG88114|UniProtKB=T1G6Y7 T1G6Y7 20216834 PTHR12400:SF26 INOSITOL POLYPHOSPHATE KINASE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;organophosphate biosynthetic process#GO:0090407 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 kinase#PC00137 HELRO|EnsemblGenome=HelroG185187|UniProtKB=T1FMH5 T1FMH5 20210024 PTHR10589:SF17 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG174119|UniProtKB=T1F7N2 T1F7N2 20204831 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG76151|UniProtKB=T1G2F7 T1G2F7 20215255 PTHR31302:SF0 TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN HELRO|EnsemblGenome=HelroG168837|UniProtKB=T1F110 T1F110 20202510 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG158830|UniProtKB=T1ENB4 T1ENB4 20198064 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG113786|UniProtKB=T1EFW4 T1EFW4 20195466 PTHR11309:SF148 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 1 protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172051|UniProtKB=T1F4Z2 T1F4Z2 20203891 PTHR13028:SF0 RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED RRNA-PROCESSING PROTEIN EBP2-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG111184|UniProtKB=T1EF92 T1EF92 20195244 PTHR14083:SF0 YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN YIP1-INTERACTING FACTOR 1, ISOFORM C localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG160319|UniProtKB=T1EQ33 T1EQ33 20198683 PTHR19972:SF16 CALBINDIN CALBINDIN-32 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;nucleus#GO:0005634;neuron projection#GO:0043005;presynapse#GO:0098793;cytosol#GO:0005829;axon terminus#GO:0043679;cell junction#GO:0030054;terminal bouton#GO:0043195;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection terminus#GO:0044306;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG164206|UniProtKB=T1EV35 T1EV35 20200435 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153263|UniProtKB=T1EL20 T1EL20 20197270 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66057|UniProtKB=T1FYG5 T1FYG5 20213863 PTHR11830:SF0 40S RIBOSOMAL PROTEIN S3A SMALL RIBOSOMAL SUBUNIT PROTEIN ES1 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG176191|UniProtKB=T1FAA2 T1FAA2 20205751 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86641|UniProtKB=T1G6E9 T1G6E9 20216646 PTHR23257:SF991 SERINE-THREONINE PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE PHG2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Raf#P00893 HELRO|EnsemblGenome=HelroG153320|UniProtKB=T1EL37 T1EL37 20197287 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157380|UniProtKB=T1EMA6 T1EMA6 20197706 PTHR12886:SF0 PIG-M MANNOSYLTRANSFERASE GPI ALPHA-1,4-MANNOSYLTRANSFERASE I, CATALYTIC SUBUNIT glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;mannosyltransferase complex#GO:0031501 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG177424|UniProtKB=T1FBN9 T1FBN9 20206238 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191310|UniProtKB=T1FSV5 T1FSV5 20211902 PTHR24348:SF79 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED AUTOPHAGY-RELATED 1, ISOFORM B catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;cell projection morphogenesis#GO:0048858;cell growth#GO:0016049;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;axon extension#GO:0048675;cellular component assembly#GO:0022607;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;process utilizing autophagic mechanism#GO:0061919;neuron projection extension#GO:1990138;developmental growth involved in morphogenesis#GO:0060560;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;regulation of autophagy#GO:0010506;cell development#GO:0048468;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;autophagy of mitochondrion#GO:0000422;neurogenesis#GO:0022008;regulation of catabolic process#GO:0009894;cellular developmental process#GO:0048869;developmental growth#GO:0048589;mitophagy#GO:0000423;regulation of metabolic process#GO:0019222;reticulophagy#GO:0061709;axon development#GO:0061564;response to nutrient levels#GO:0031667;plasma membrane bounded cell projection organization#GO:0120036;macroautophagy#GO:0016236;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;organelle assembly#GO:0070925;vacuole organization#GO:0007033;system development#GO:0048731;anatomical structure development#GO:0048856;response to starvation#GO:0042594;developmental cell growth#GO:0048588;piecemeal microautophagy of the nucleus#GO:0034727;regulation of cellular process#GO:0050794;catabolic process#GO:0009056 autophagosome#GO:0005776;phagophore assembly site#GO:0000407;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG178217|UniProtKB=T1FCY4 T1FCY4 20206683 PTHR46704:SF10 CXC DOMAIN-CONTAINING PROTEIN-RELATED TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184502|UniProtKB=T1FLC3 T1FLC3 20209622 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG170928|UniProtKB=T1F3L8 T1F3L8 20203417 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79952|UniProtKB=T1G3V6 T1G3V6 20215754 PTHR24637:SF422 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180007|UniProtKB=T1FFC2 T1FFC2 20207521 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156671|UniProtKB=T1ELZ8 T1ELZ8 20197598 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;lyase activity#GO:0016829;metal ion binding#GO:0046872;cation binding#GO:0043169;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 homeostatic process#GO:0042592;carbohydrate metabolic process#GO:0005975;cellular response to stimulus#GO:0051716;hexose biosynthetic process#GO:0019319;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;response to starvation#GO:0042594;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;response to glucose#GO:0009749;response to nutrient levels#GO:0031667;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;carbohydrate homeostasis#GO:0033500;carboxylic acid metabolic process#GO:0019752;response to hexose#GO:0009746;intracellular glucose homeostasis#GO:0001678;response to carbohydrate#GO:0009743;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to monosaccharide#GO:0034284;carbohydrate biosynthetic process#GO:0016051;response to lipid#GO:0033993;response to chemical#GO:0042221;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;gluconeogenesis#GO:0006094;cellular response to oxygen-containing compound#GO:1901701;response to stress#GO:0006950;glucose homeostasis#GO:0042593;glucose metabolic process#GO:0006006;chemical homeostasis#GO:0048878;alcohol metabolic process#GO:0006066;monosaccharide metabolic process#GO:0005996;cellular response to glucose stimulus#GO:0071333;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG71783|UniProtKB=T1G0R7 T1G0R7 20214665 PTHR19970:SF0 RIBOSOMAL PROTEIN L39E LARGE RIBOSOMAL SUBUNIT PROTEIN EL39 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG123182|UniProtKB=T1EGX2 T1EGX2 20195822 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE GLYCOPROTEIN 3-ALPHA-L-FUCOSYLTRANSFERASE A hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824;alpha-(1->3)-fucosyltransferase activity#GO:0046920;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG108261|UniProtKB=T1EEH7 T1EEH7 20194979 PTHR11647:SF1 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;dihydropyrimidinase activity#GO:0004157;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824 pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;pyrimidine nucleobase metabolic process#GO:0006206 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HELRO|EnsemblGenome=HelroG160824|UniProtKB=T1EQS2 T1EQS2 20198922 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG110370|UniProtKB=T1EF18 T1EF18 20195170 PTHR44156:SF33 SUPERNUMERARY LIMBS, ISOFORM B-RELATED DYNEIN ASSEMBLY FACTOR WITH WD REPEAT DOMAINS 1 pattern specification process#GO:0007389;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;cilium organization#GO:0044782;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;determination of left/right symmetry#GO:0007368;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;developmental process#GO:0032502;left/right pattern formation#GO:0060972;specification of symmetry#GO:0009799;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;determination of bilateral symmetry#GO:0009855;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;regionalization#GO:0003002;multicellular organismal process#GO:0032501 HELRO|EnsemblGenome=HelroG86926|UniProtKB=T1G6J2 T1G6J2 20216689 PTHR44129:SF18 WD REPEAT-CONTAINING PROTEIN POP1 LISSENCEPHALY-1 HOMOLOG intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;organelle localization#GO:0051640;axonal transport#GO:0098930;retrograde axonal transport#GO:0008090;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based movement#GO:0007018;centrosome localization#GO:0051642 kinetochore#GO:0000776;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG183929|UniProtKB=T1FKB2 T1FKB2 20209261 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG75060|UniProtKB=T1G200 T1G200 20215098 PTHR12668:SF58 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14 HOMOLOG membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740 HELRO|EnsemblGenome=HelroG192553|UniProtKB=T1FU26 T1FU26 20212322 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155472|UniProtKB=T1ELI5 T1ELI5 20197435 PTHR16537:SF1 SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1 PROTEIN ZNRD2 HELRO|EnsemblGenome=HelroG158544|UniProtKB=T1EMX9 T1EMX9 20197929 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG169968|UniProtKB=T1F2H7 T1F2H7 20203027 PTHR14555:SF3 MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED RABBD DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;myosin binding#GO:0017022 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629 myelin protein#PC00161 HELRO|EnsemblGenome=HelroG86254|UniProtKB=T1G694 T1G694 20216591 PTHR31200:SF1 INO80 COMPLEX SUBUNIT C INO80 COMPLEX SUBUNIT C chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 Ino80 complex#GO:0031011;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG174918|UniProtKB=T1F8M1 T1F8M1 20205170 PTHR39075:SF1 FI19908P1 FI19908P1 HELRO|EnsemblGenome=HelroG181081|UniProtKB=T1FGL5 T1FGL5 20207964 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG133824|UniProtKB=T1EI26 T1EI26 20196226 PTHR12215:SF10 PHOSPHOPANTETHEINE TRANSFERASE L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181600|UniProtKB=T1FH56 T1FH56 20208155 PTHR22973:SF12 LD35087P LD35087P HELRO|EnsemblGenome=HelroG107069|UniProtKB=T1EE71 T1EE71 20194873 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG176657|UniProtKB=T1FAR9 T1FAR9 20205918 PTHR10383:SF9 SERINE INCORPORATOR SERINE INCORPORATOR, ISOFORM F membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG132012|UniProtKB=T1EHX0 T1EHX0 20196170 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG168858|UniProtKB=T1F119 T1F119 20202519 PTHR24182:SF13 ANKYRIN REPEAT AND SOCS BOX CONTAINING 4 LD18443P HELRO|EnsemblGenome=HelroG160174|UniProtKB=T1EPX3 T1EPX3 20198623 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG70323|UniProtKB=T1G047 T1G047 20214445 PTHR24241:SF188 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171296|UniProtKB=T1F417 T1F417 20203566 PTHR15698:SF4 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166313|UniProtKB=T1EY05 T1EY05 20201455 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN EXPRESSED PROTEIN methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169022|UniProtKB=T1F197 T1F197 20202597 PTHR31855:SF2 GUANINE NUCLEOTIDE EXCHANGE C9ORF72 GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 regulation of metabolic process#GO:0019222;regulation of TOR signaling#GO:0032006;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;localization#GO:0051179 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;autophagosome#GO:0005776;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG102264|UniProtKB=T1ED90 T1ED90 20194542 PTHR12933:SF0 ORF PROTEIN-RELATED U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;U3 snoRNA binding#GO:0034511;RNA binding#GO:0003723 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG186164|UniProtKB=T1FNR2 T1FNR2 20210459 PTHR24068:SF116 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Parkinson disease#P00049>UbcH8#P01223;Parkinson disease#P00049>UbcH7#P01224 HELRO|EnsemblGenome=HelroG95765|UniProtKB=T1G974 T1G974 20217621 PTHR46314:SF2 SOLUTE CARRIER FAMILY 25 MEMBER 44 SOLUTE CARRIER FAMILY 25 MEMBER 44 carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;branched-chain amino acid transmembrane transporter activity#GO:0015658 establishment of localization#GO:0051234;localization#GO:0051179;branched-chain amino acid transport#GO:0015803;nitrogen compound transport#GO:0071705;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG153255|UniProtKB=T1EL19 T1EL19 20197269 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG120633|UniProtKB=T1EGQ3 T1EGQ3 20195753 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG165054|UniProtKB=T1EW77 T1EW77 20200827 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG180415|UniProtKB=T1FFW7 T1FFW7 20207716 PTHR24249:SF411 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG186206|UniProtKB=T1FNT4 T1FNT4 20210481 PTHR43272:SF32 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 ligase#PC00142 HELRO|EnsemblGenome=HelroG173089|UniProtKB=T1F6B7 T1F6B7 20204366 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG171023|UniProtKB=T1F3Q2 T1F3Q2 20203451 PTHR24026:SF141 FAT ATYPICAL CADHERIN-RELATED CADHERIN DOMAIN-CONTAINING PROTEIN animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron projection development#GO:0031175;cell-cell adhesion#GO:0098609;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036 cell-cell junction#GO:0005911;anchoring junction#GO:0070161;adherens junction#GO:0005912;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG190612|UniProtKB=T1FS48 T1FS48 20211645 PTHR13620:SF133 3-5 EXONUCLEASE EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2 hydrolase activity#GO:0016787;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;DNA exonuclease activity#GO:0004529 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;recombinational repair#GO:0000725 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG104083|UniProtKB=T1EDJ5 T1EDJ5 20194647 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG68960|UniProtKB=T1FZM6 T1FZM6 20214274 PTHR11538:SF41 PHENYLALANYL-TRNA SYNTHETASE PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG193811|UniProtKB=T1FVD7 T1FVD7 20212783 PTHR46097:SF3 G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP ARF GTPASE-ACTIVATING PROTEIN GIT molecular function activator activity#GO:0140677;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047 system development#GO:0048731;anatomical structure development#GO:0048856;cellular localization#GO:0051641;localization#GO:0051179;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of G protein-coupled receptor signaling pathway#GO:0008277;synaptic vesicle cycle#GO:0099504;regulation of response to stimulus#GO:0048583;transport#GO:0006810;developmental process#GO:0032502;nervous system development#GO:0007399;head development#GO:0060322;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;brain development#GO:0007420;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054 HELRO|EnsemblGenome=HelroG160543|UniProtKB=T1EQE4 T1EQE4 20198794 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG69301|UniProtKB=T1FZT1 T1FZT1 20214329 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG179157|UniProtKB=T1FEA0 T1FEA0 20207149 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110124|UniProtKB=T1EEZ5 T1EEZ5 20195147 PTHR24248:SF120 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG157491|UniProtKB=T1EMC2 T1EMC2 20197722 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289 secretion#GO:0046903;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular component organization#GO:0051128;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;export from cell#GO:0140352;regulation of organelle organization#GO:0033043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;vesicle-mediated transport in synapse#GO:0099003;regulation of transport#GO:0051049;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;regulation of localization#GO:0032879;regulated exocytosis#GO:0045055;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;axon#GO:0030424;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;organelle membrane#GO:0031090;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell projection#GO:0042995;intracellular vesicle#GO:0097708;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG127644|UniProtKB=T1EHG1 T1EHG1 20196011 PTHR23235:SF183 KRUEPPEL-LIKE TRANSCRIPTION FACTOR DENDRITIC ARBOR REDUCTION PROTEIN 1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG66814|UniProtKB=T1FYR3 T1FYR3 20213961 PTHR11003:SF359 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG192463|UniProtKB=T1FTZ6 T1FTZ6 20212293 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133 HELRO|EnsemblGenome=HelroG81988|UniProtKB=T1G4L3 T1G4L3 20216011 PTHR10730:SF45 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;dioxygenase activity#GO:0051213;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;collagen fibril organization#GO:0030199;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178867|UniProtKB=T1FDU3 T1FDU3 20206992 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62698|UniProtKB=T1FX38 T1FX38 20213386 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;cation binding#GO:0043169;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234 biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;cellular response to nutrient levels#GO:0031669;regulation of carbohydrate metabolic process#GO:0006109;cellular response to starvation#GO:0009267;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to starvation#GO:0042594;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;cellular response to stress#GO:0033554 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG173606|UniProtKB=T1F712 T1F712 20204611 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG162122|UniProtKB=T1ES93 T1ES93 20199443 PTHR12154:SF4 GLYCOSYL TRANSFERASE-RELATED UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220 HELRO|EnsemblGenome=HelroG187537|UniProtKB=T1FPA5 T1FPA5 20210652 PTHR43658:SF14 SHORT-CHAIN DEHYDROGENASE/REDUCTASE 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;lipid modification#GO:0030258;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG110122|UniProtKB=T1EEZ4 T1EEZ4 20195146 PTHR24390:SF278 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 772 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG185949|UniProtKB=T1FNH1 T1FNH1 20210368 PTHR12974:SF36 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740 positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;regulation of RNA stability#GO:0043487 HELRO|EnsemblGenome=HelroG94925|UniProtKB=T1G940 T1G940 20217587 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;inorganic ion homeostasis#GO:0098771;monoatomic ion transport#GO:0006811;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;export from cell#GO:0140352;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG155740|UniProtKB=T1ELL8 T1ELL8 20197468 PTHR12241:SF162 TUBULIN POLYGLUTAMYLASE TUBULIN MONOGLUTAMYLASE TTLL4 protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG106966|UniProtKB=T1EE64 T1EE64 20194866 PTHR45703:SF41 DYNEIN HEAVY CHAIN CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1 microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG113373|UniProtKB=T1EFR9 T1EFR9 20195421 PTHR46520:SF1 SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;primary metabolic process#GO:0044238;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;regulation of lipid metabolic process#GO:0019216 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG135774|UniProtKB=T1EIA6 T1EIA6 20196306 PTHR16515:SF88 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG181625|UniProtKB=T1FH67 T1FH67 20208166 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG127402|UniProtKB=T1EHE5 T1EHE5 20195995 PTHR24341:SF6 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN INVECTED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG165655|UniProtKB=T1EX48 T1EX48 20201148 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169089|UniProtKB=T1F1D6 T1F1D6 20202636 PTHR23424:SF34 SERUM AMYLOID A LD40680P organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG79532|UniProtKB=T1G3P8 T1G3P8 20215696 PTHR22603:SF66 CHOLINE/ETHANOALAMINE KINASE ETHANOLAMINE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate biosynthetic process#GO:0090407;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 kinase#PC00137 HELRO|EnsemblGenome=HelroG77502|UniProtKB=T1G2Y8 T1G2Y8 20215436 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG121545|UniProtKB=T1EGS3 T1EGS3 20195773 PTHR18945:SF856 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chloride transmembrane transport#GO:1902476;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG62554|UniProtKB=T1FX23 T1FX23 20213371 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;carbohydrate derivative binding#GO:0097367 nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound metabolic process#GO:0006139;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;ADP catabolic process#GO:0046032;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282 intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 transferase#PC00220;kinase#PC00137;carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG191479|UniProtKB=T1FT08 T1FT08 20211955 PTHR13817:SF166 TITIN MYOMESIN AND MYOSIN BINDING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG168920|UniProtKB=T1F147 T1F147 20202547 PTHR21522:SF32 PROTON CHANNEL OTOP PROTON CHANNEL OTOPLC passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG191887|UniProtKB=T1FTE1 T1FTE1 20212088 PTHR46557:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10 protein phosphatase binding#GO:0019903;protein binding#GO:0005515;enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG163690|UniProtKB=T1EUC9 T1EUC9 20200179 PTHR12011:SF481 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG192237|UniProtKB=T1FTR0 T1FTR0 20212207 PTHR48407:SF1 CRANIOFACIAL DEVELOPMENT PROTEIN 1 HETEROCHROMATIN-STABILIZING PROTEIN CFDP1 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;Swr1 complex#GO:0000812;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG94735|UniProtKB=T1G927 T1G927 20217574 PTHR11040:SF223 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324 inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG189737|UniProtKB=T1FRB5 T1FRB5 20211362 PTHR24031:SF781 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX56-RELATED response to external stimulus#GO:0009605;defense response#GO:0006952;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;response to other organism#GO:0051707;maturation of LSU-rRNA#GO:0000470;macromolecule biosynthetic process#GO:0009059;rRNA processing#GO:0006364;response to virus#GO:0009615;response to external biotic stimulus#GO:0043207;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;biological process involved in interspecies interaction between organisms#GO:0044419;ribonucleoprotein complex biogenesis#GO:0022613;response to stimulus#GO:0050896;defense response to virus#GO:0051607 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG185249|UniProtKB=T1FMK0 T1FMK0 20210049 PTHR11922:SF6 GMP SYNTHASE-RELATED GMP SYNTHASE [GLUTAMINE-HYDROLYZING] ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879 purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;purine ribonucleoside monophosphate metabolic process#GO:0009167 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 ligase#PC00142 De novo purine biosynthesis#P02738>GMP synthase#P02899 HELRO|EnsemblGenome=HelroG184823|UniProtKB=T1FM19 T1FM19 20209868 PTHR11071:SF559 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG84539|UniProtKB=T1G5K0 T1G5K0 20216347 PTHR11999:SF70 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE MIP05841P lyase#PC00144;decarboxylase#PC00089 Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066;5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961 HELRO|EnsemblGenome=HelroG190787|UniProtKB=T1FSA6 T1FSA6 20211703 PTHR13316:SF0 ZINC FINGER, CCHC DOMAIN CONTAINING 8 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66928|UniProtKB=T1FYT4 T1FYT4 20213982 PTHR24055:SF79 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 15 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 PDGF signaling pathway#P00047>ERK#P01143;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Interleukin signaling pathway#P00036>ERK#P00965;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Parkinson disease#P00049>ERK#P01211;EGF receptor signaling pathway#P00018>ERK1-2#P00543 HELRO|EnsemblGenome=HelroG188829|UniProtKB=T1FQE4 T1FQE4 20211041 PTHR12210:SF70 DULLARD PROTEIN PHOSPHATASE CTD NUCLEAR ENVELOPE PHOSPHATASE 1 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG184238|UniProtKB=T1FKT9 T1FKT9 20209438 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193939|UniProtKB=T1FVH9 T1FVH9 20212825 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphoric ester hydrolase activity#GO:0042578 nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG73062|UniProtKB=T1G194 T1G194 20214842 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion homeostasis#GO:0055074;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;regulation of cytosolic calcium ion concentration#GO:0051480 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG189164|UniProtKB=T1FQQ7 T1FQQ7 20211154 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG157395|UniProtKB=T1EMA8 T1EMA8 20197708 PTHR23137:SF6 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN HELRO|EnsemblGenome=HelroG156953|UniProtKB=T1EM39 T1EM39 20197639 PTHR46029:SF7 C-TERMINAL-BINDING PROTEIN C-TERMINAL-BINDING PROTEIN transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription factor binding#GO:0008134;transcription corepressor activity#GO:0003714;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;transcription regulator activity#GO:0140110;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217 Wnt signaling pathway#P00057>C-terminal Binding Protein#P01439 HELRO|EnsemblGenome=HelroG158597|UniProtKB=T1EN00 T1EN00 20197950 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG92484|UniProtKB=T1G8H2 T1G8H2 20217369 PTHR11863:SF247 STEROL DESATURASE LATHOSTEROL OXIDASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;secondary alcohol biosynthetic process#GO:1902653;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 oxidase#PC00175 HELRO|EnsemblGenome=HelroG148404|UniProtKB=T1EK77 T1EK77 20196977 PTHR24333:SF19 HOMEO BOX HB9 LIKE A-RELATED BRAIN-SPECIFIC HOMEOBOX PROTEIN HOMOLOG homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG188516|UniProtKB=T1FQ30 T1FQ30 20210927 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG180365|UniProtKB=T1FFU3 T1FFU3 20207692 PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;kinetochore assembly#GO:0051382;organelle assembly#GO:0070925;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;kinetochore organization#GO:0051383;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226 chaperone#PC00072 HELRO|EnsemblGenome=HelroG110114|UniProtKB=T1EEZ3 T1EEZ3 20195145 PTHR46356:SF1 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG185843|UniProtKB=T1FNC9 T1FNC9 20210326 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG68763|UniProtKB=T1FZJ4 T1FZJ4 20214242 PTHR11842:SF11 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A negative regulation of sister chromatid segregation#GO:0033046;cellular process#GO:0009987;mitotic spindle assembly checkpoint signaling#GO:0007094;signal transduction#GO:0007165;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;regulation of cell cycle process#GO:0010564;negative regulation of chromosome segregation#GO:0051985;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;regulation of chromosome segregation#GO:0051983;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of mitotic sister chromatid separation#GO:2000816;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;negative regulation of cell cycle process#GO:0010948;regulation of mitotic sister chromatid separation#GO:0010965;mitotic cell cycle process#GO:1903047;regulation of mitotic nuclear division#GO:0007088;negative regulation of chromosome separation#GO:1905819;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;negative regulation of chromosome organization#GO:2001251;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of mitotic sister chromatid segregation#GO:0033047 kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG171891|UniProtKB=T1F4T1 T1F4T1 20203830 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG89986|UniProtKB=T1G7J9 T1G7J9 20217046 PTHR24056:SF607 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 17 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG89741|UniProtKB=T1G7H0 T1G7H0 20217017 PTHR13009:SF22 HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1 ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 1 ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG69241|UniProtKB=T1FZR6 T1FZR6 20214314 PTHR24543:SF339 MULTICOPPER OXIDASE-RELATED LACTADHERIN-LIKE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG90057|UniProtKB=T1G7K4 T1G7K4 20217051 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG160496|UniProtKB=T1EQB5 T1EQB5 20198765 PTHR24121:SF23 NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED ANKYRIN REPEAT PROTEIN A HELRO|EnsemblGenome=HelroG161480|UniProtKB=T1ERI8 T1ERI8 20199188 PTHR24173:SF74 ANKYRIN REPEAT CONTAINING ANK_REP_REGION DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG112734|UniProtKB=T1EFL7 T1EFL7 20195369 PTHR11817:SF3 PYRUVATE KINASE AT14039P-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;pyruvate kinase activity#GO:0004743 aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine-containing compound catabolic process#GO:0072523;ADP catabolic process#GO:0046032;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HELRO|EnsemblGenome=HelroG83187|UniProtKB=T1G515 T1G515 20216163 PTHR10472:SF5 D-TYROSYL-TRNA TYR DEACYLASE D-AMINOACYL-TRNA DEACYLASE 1 catalytic activity, acting on RNA#GO:0140098;deacylase activity#GO:0160215;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;carboxylic ester hydrolase activity#GO:0052689 cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 esterase#PC00097;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG91097|UniProtKB=T1G7Z8 T1G7Z8 20217195 PTHR24247:SF238 5-HYDROXYTRYPTAMINE RECEPTOR DOPAMINE RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 dendritic tree#GO:0097447;dendrite#GO:0030425;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Dopamine receptor mediated signaling pathway#P05912>D1/D5#P05948 HELRO|EnsemblGenome=HelroG87798|UniProtKB=T1G6V4 T1G6V4 20216801 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG119463|UniProtKB=T1EGN2 T1EGN2 20195732 PTHR24238:SF57 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 83 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157859|UniProtKB=T1EMH0 T1EMH0 20197770 PTHR24055:SF615 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;FGF signaling pathway#P00021>p38#P00644;TGF-beta signaling pathway#P00052>P38#P01275;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>p38#P00562;Ras Pathway#P04393>p38#P04558;Oxidative stress response#P00046>p38#P01135;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Parkinson disease#P00049>p38 MAPK#P01212 HELRO|EnsemblGenome=HelroG181789|UniProtKB=T1FHB9 T1FHB9 20208218 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG79055|UniProtKB=T1G3J6 T1G3J6 20215644 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH19970P-RELATED active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;sodium ion transport#GO:0006814 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185096|UniProtKB=T1FME2 T1FME2 20209991 PTHR47981:SF45 RAB FAMILY RAS-RELATED PROTEIN RAB7 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 cellular component organization#GO:0016043;vesicle fusion#GO:0006906;endocytosis#GO:0006897;endosome to lysosome transport#GO:0008333;organelle assembly#GO:0070925;lysosomal transport#GO:0007041;vacuole organization#GO:0007033;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome organization#GO:0007040;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;transport#GO:0006810;lytic vacuole organization#GO:0080171;phagolysosome assembly#GO:0001845;phagocytosis#GO:0006909;intracellular transport#GO:0046907;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657 lytic vacuole#GO:0000323;endomembrane system#GO:0012505;late endosome#GO:0005770;phagocytic vesicle#GO:0045335;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG184600|UniProtKB=T1FLK0 T1FLK0 20209699 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178406|UniProtKB=T1FD46 T1FD46 20206745 PTHR21443:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7 protein localization to Golgi apparatus#GO:0034067;cellular localization#GO:0051641;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;Golgi organization#GO:0007030;protein localization to organelle#GO:0033365;endomembrane system organization#GO:0010256 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;COG complex#GO:0017119;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG159415|UniProtKB=T1EP07 T1EP07 20198307 PTHR46458:SF5 BLR2807 PROTEIN GLOBIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104 response to stimulus#GO:0050896;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;response to hypoxia#GO:0001666;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 transporter#PC00227 HELRO|EnsemblGenome=HelroG182455|UniProtKB=T1FI80 T1FI80 20208529 PTHR48034:SF37 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG131960|UniProtKB=T1EHW9 T1EHW9 20196169 PTHR13233:SF0 MICROSPHERULE PROTEIN 1 MICROSPHERULE PROTEIN 1 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;NSL complex#GO:0044545;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562 HELRO|EnsemblGenome=HelroG164283|UniProtKB=T1EV73 T1EV73 20200473 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG188141|UniProtKB=T1FPP5 T1FPP5 20210792 PTHR15537:SF2 F-BOX ONLY PROTEIN 7 F-BOX ONLY PROTEIN 7 HELRO|EnsemblGenome=HelroG115644|UniProtKB=T1EG97 T1EG97 20195599 PTHR11188:SF144 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG187369|UniProtKB=T1FP94 T1FP94 20210641 PTHR28570:SF18 ASPARTYL AMINOPEPTIDASE ASPARTYL AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177581|UniProtKB=T1FBW2 T1FBW2 20206311 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG66220|UniProtKB=T1FYI6 T1FYI6 20213884 PTHR31107:SF2 APOPTOGENIC PROTEIN 1, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG189730|UniProtKB=T1FRB0 T1FRB0 20211357 PTHR23320:SF167 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG171300|UniProtKB=T1F421 T1F421 20203570 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG188966|UniProtKB=T1FQI6 T1FQI6 20211083 PTHR46510:SF1 BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA replication#GO:0045740;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of cellular component organization#GO:0051128;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of chromatin organization#GO:1902275;positive regulation of metabolic process#GO:0009893;regulation of DNA replication#GO:0006275;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;ISWI-type complex#GO:0031010;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603 HELRO|EnsemblGenome=HelroG167348|UniProtKB=T1EZA3 T1EZA3 20201903 PTHR24543:SF339 MULTICOPPER OXIDASE-RELATED LACTADHERIN-LIKE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG163020|UniProtKB=T1ETK8 T1ETK8 20199908 PTHR13723:SF306 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG178923|UniProtKB=T1FDW6 T1FDW6 20207015 PTHR12307:SF57 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT CBM21 DOMAIN-CONTAINING PROTEIN protein phosphatase binding#GO:0019903;carbohydrate binding#GO:0030246;protein binding#GO:0005515;enzyme binding#GO:0019899;polysaccharide binding#GO:0030247;phosphatase binding#GO:0019902;binding#GO:0005488 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of polysaccharide metabolic process#GO:0032881;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of carbohydrate metabolic process#GO:0006109;regulation of glycogen biosynthetic process#GO:0005979;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG100540|UniProtKB=T1ED03 T1ED03 20194455 PTHR24256:SF575 TRYPTASE-RELATED LD47230P-RELATED serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG71229|UniProtKB=T1G0I1 T1G0I1 20214579 PTHR12586:SF1 CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL transferase#PC00220 HELRO|EnsemblGenome=HelroG129786|UniProtKB=T1EHS2 T1EHS2 20196122 PTHR24248:SF199 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62898|UniProtKB=T1FX70 T1FX70 20213418 PTHR13800:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG76804|UniProtKB=T1G2P6 T1G2P6 20215344 PTHR24185:SF10 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA hydrolase activity#GO:0016787;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;A2-type glycerophospholipase activity#GO:0004623;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569 unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;fatty acid metabolic process#GO:0006631;cellular process#GO:0009987;arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;long-chain fatty acid metabolic process#GO:0001676;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690 cellular anatomical structure#GO:0110165;membrane#GO:0016020 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG155548|UniProtKB=T1ELI7 T1ELI7 20197437 PTHR11935:SF94 BETA LACTAMASE DOMAIN HYDROXYACYLGLUTATHIONE HYDROLASE hydrolase activity#GO:0016787;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG110237|UniProtKB=T1EF08 T1EF08 20195160 PTHR10245:SF15 ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1 ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 HELRO|EnsemblGenome=HelroG187113|UniProtKB=T1FP71 T1FP71 20210618 PTHR42807:SF1 GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178673|UniProtKB=T1FDJ8 T1FDJ8 20206897 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106950|UniProtKB=T1EE61 T1EE61 20194863 PTHR13817:SF175 TITIN NEUROGLIAN structural protein#PC00211 HELRO|EnsemblGenome=HelroG73612|UniProtKB=T1G1G4 T1G1G4 20214912 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cell projection assembly#GO:0030031;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG110871|UniProtKB=T1EF59 T1EF59 20195211 PTHR24390:SF278 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 772 double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG156526|UniProtKB=T1ELY0 T1ELY0 20197580 PTHR10792:SF8 60S RIBOSOMAL PROTEIN L24 RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED cellular process#GO:0009987;cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG149332|UniProtKB=T1EKC7 T1EKC7 20197027 PTHR35249:SF2 DYNEIN REGULATORY COMPLEX SUBUNIT 7 DYNEIN REGULATORY COMPLEX SUBUNIT 7 cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;flagellated sperm motility#GO:0030317;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;cilium movement involved in cell motility#GO:0060294;sperm motility#GO:0097722;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG164986|UniProtKB=T1EW26 T1EW26 20200776 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG145942|UniProtKB=T1EJP0 T1EJP0 20196790 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168053|UniProtKB=T1F041 T1F041 20202191 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN CC8L18.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG173124|UniProtKB=T1F6E5 T1F6E5 20204394 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN SHIFTED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG182572|UniProtKB=T1FID6 T1FID6 20208585 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105878|UniProtKB=T1EDY2 T1EDY2 20194784 PTHR10555:SF170 SORTING NEXIN FI18122P1 small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167 transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;retromer complex#GO:0030904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG95514|UniProtKB=T1G965 T1G965 20217612 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;nervous system development#GO:0007399;receptor clustering#GO:0043113;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;signaling#GO:0023052;developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;trans-synaptic signaling#GO:0099537;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;system development#GO:0048731;anatomical structure development#GO:0048856;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cell communication#GO:0007154;localization#GO:0051179;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916 postsynapse#GO:0098794;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density membrane#GO:0098839;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;synaptic membrane#GO:0097060;neuromuscular junction#GO:0031594;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171655|UniProtKB=T1F4I8 T1F4I8 20203737 PTHR15367:SF2 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG106153|UniProtKB=T1EE04 T1EE04 20194806 PTHR47096:SF1 MISSHAPEN LIKE KINASE 1 NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG190283|UniProtKB=T1FRV0 T1FRV0 20211547 PTHR13524:SF2 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR14 phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG186449|UniProtKB=T1FNZ8 T1FNZ8 20210545 PTHR11606:SF13 GLUTAMATE DEHYDROGENASE GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 Glutamine glutamate conversion#P02745>Glutamate Dehydrogenase#P02967 HELRO|EnsemblGenome=HelroG81623|UniProtKB=T1G4G7 T1G4G7 20215965 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG178890|UniProtKB=T1FDV1 T1FDV1 20207000 PTHR24104:SF50 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED NHL DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG181603|UniProtKB=T1FH59 T1FH59 20208158 PTHR48051:SF1 FAMILY NOT NAMED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG156470|UniProtKB=T1ELX2 T1ELX2 20197572 PTHR10934:SF2 60S RIBOSOMAL PROTEIN L18 LARGE RIBOSOMAL SUBUNIT PROTEIN EL18 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG181014|UniProtKB=T1FGJ1 T1FGJ1 20207940 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG73178|UniProtKB=T1G1B3 T1G1B3 20214861 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG146879|UniProtKB=T1EJV3 T1EJV3 20196853 PTHR11829:SF416 FORKHEAD BOX PROTEIN FORKHEAD DOMAIN 102C DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG169161|UniProtKB=T1F1I2 T1F1I2 20202682 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156075|UniProtKB=T1ELR5 T1ELR5 20197515 PTHR10142:SF0 DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;damaged DNA binding#GO:0003684 chromosome organization#GO:0051276;cellular response to abiotic stimulus#GO:0071214;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;response to UV#GO:0009411;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297;nucleotide-excision repair#GO:0006289;cellular process#GO:0009987;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;response to stress#GO:0006950;organelle organization#GO:0006996;cellular response to stress#GO:0033554;cellular response to radiation#GO:0071478;cellular response to environmental stimulus#GO:0104004;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleotide-excision repair complex#GO:0000109;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA metabolism protein#PC00009;damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG110155|UniProtKB=T1EF00 T1EF00 20195152 PTHR37456:SF15 SI:CH211-266K2.1 MULTIPLEXIN HELRO|EnsemblGenome=HelroG174247|UniProtKB=T1F7V6 T1F7V6 20204905 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79568|UniProtKB=T1G3Q2 T1G3Q2 20215700 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG76167|UniProtKB=T1G2G1 T1G2G1 20215259 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG180362|UniProtKB=T1FFU0 T1FFU0 20207689 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63211|UniProtKB=T1FXC4 T1FXC4 20213472 PTHR13326:SF31 TRNA PSEUDOURIDINE SYNTHASE D PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866 metabolic process#GO:0008152;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;pseudouridine synthesis#GO:0001522;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG138770|UniProtKB=T1EIX5 T1EIX5 20196525 PTHR28520:SF15 MITOTIC-SPINDLE ORGANIZING PROTEIN 1 MITOTIC-SPINDLE ORGANIZING PROTEIN 1 spindle organization#GO:0007051;chromosome organization#GO:0051276;microtubule polymerization#GO:0046785;mitotic cell cycle process#GO:1903047;mitotic sister chromatid segregation#GO:0000070;microtubule polymerization or depolymerization#GO:0031109;mitotic spindle assembly#GO:0090307;organelle assembly#GO:0070925;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;nuclear division#GO:0000280;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;mitotic spindle organization#GO:0007052 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813 HELRO|EnsemblGenome=HelroG191787|UniProtKB=T1FTB7 T1FTB7 20212064 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG159100|UniProtKB=T1ENL2 T1ENL2 20198162 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG175638|UniProtKB=T1F9G2 T1F9G2 20205461 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91647|UniProtKB=T1G871 T1G871 20217268 PTHR12626:SF15 PROGRAMMED CELL DEATH 4 PROGRAMMED CELL DEATH PROTEIN 4 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 translation factor#PC00223 HELRO|EnsemblGenome=HelroG188714|UniProtKB=T1FQA5 T1FQA5 20211002 PTHR13228:SF3 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;COG complex#GO:0017119;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG180187|UniProtKB=T1FFK0 T1FFK0 20207599 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG164925|UniProtKB=T1EVZ2 T1EVZ2 20200742 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG104176|UniProtKB=T1EDK0 T1EDK0 20194652 PTHR13140:SF870 MYOSIN MYOSIN HEAVY CHAIN 95F isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based movement#GO:0030048;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;actin cytoskeleton#GO:0015629;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG168752|UniProtKB=T1F0X5 T1F0X5 20202475 PTHR23024:SF24 ARYLACETAMIDE DEACETYLASE ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN deacetylase#PC00087 HELRO|EnsemblGenome=HelroG181601|UniProtKB=T1FH57 T1FH57 20208156 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159694|UniProtKB=T1EPB5 T1EPB5 20198415 PTHR13124:SF12 39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN ML46 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG108278|UniProtKB=T1EEI0 T1EEI0 20194982 PTHR15316:SF1 SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED SPLICING FACTOR 3A SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 spliceosomal complex#GO:0005681;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG192720|UniProtKB=T1FU80 T1FU80 20212376 PTHR11125:SF7 SUPPRESSOR OF TY 5 TRANSCRIPTION ELONGATION FACTOR SPT5 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nucleoplasm#GO:0005654;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG166858|UniProtKB=T1EYN2 T1EYN2 20201682 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152883|UniProtKB=T1EKX7 T1EKX7 20197227 PTHR33690:SF3 DUF4605 DOMAIN-CONTAINING PROTEIN DUF4605 DOMAIN-CONTAINING PROTEIN intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG165205|UniProtKB=T1EWF5 T1EWF5 20200905 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80866|UniProtKB=T1G465 T1G465 20215863 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG84702|UniProtKB=T1G5M5 T1G5M5 20216372 PTHR13131:SF14 CYSTINOSIN CYSTINOSIN L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;vacuolar transmembrane transport#GO:0034486 lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HELRO|EnsemblGenome=HelroG192901|UniProtKB=T1FUE5 T1FUE5 20212441 PTHR10219:SF43 GLYCOLIPID TRANSFER PROTEIN-RELATED GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN phospholipid binding#GO:0005543;transporter activity#GO:0005215;phospholipid transfer activity#GO:0120014;lipid binding#GO:0008289;lipid transfer activity#GO:0120013;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;lipid carrier activity#GO:0005319;ion binding#GO:0043167;molecular carrier activity#GO:0140104 lipid localization#GO:0010876;transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;lipid transport#GO:0006869;membrane organization#GO:0061024;ceramide transport#GO:0035627 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cytosol#GO:0005829 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG121032|UniProtKB=T1EGQ9 T1EGQ9 20195759 PTHR48102:SF7 ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED ATP-DEPENDENT CLPX-LIKE CHAPERONE, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 protease#PC00190 HELRO|EnsemblGenome=HelroG112427|UniProtKB=T1EFJ8 T1EFJ8 20195350 PTHR11685:SF225 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF144B transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG186265|UniProtKB=T1FNW1 T1FNW1 20210508 PTHR12683:SF13 CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;response to stimulus#GO:0050896;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;response to stress#GO:0006950;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 transferase complex#GO:1990234;transcription regulator complex#GO:0005667;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG191630|UniProtKB=T1FT54 T1FT54 20212001 PTHR13678:SF2 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A protein targeting to vacuole#GO:0006623;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein targeting to membrane#GO:0006612;intracellular protein transport#GO:0006886;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666;cellular localization#GO:0051641;protein transport#GO:0015031;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;localization#GO:0051179;protein localization to vacuole#GO:0072665;localization within membrane#GO:0051668 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;ESCRT I complex#GO:0000813;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG76714|UniProtKB=T1G2N2 T1G2N2 20215330 PTHR12772:SF0 DNA REPLICATION COMPLEX GINS PROTEIN PSF2 DNA REPLICATION COMPLEX GINS PROTEIN PSF2 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;GINS complex#GO:0000811;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;DNA replication preinitiation complex#GO:0031261;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG139567|UniProtKB=T1EIZ1 T1EIZ1 20196541 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG70230|UniProtKB=T1G036 T1G036 20214434 PTHR45728:SF9 ACETYL-COA CARBOXYLASE, ISOFORM A ACETYL-COA CARBOXYLASE, ISOFORM A catalytic activity#GO:0003824;ligase activity#GO:0016874 small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG182488|UniProtKB=T1FI94 T1FI94 20208543 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159958|UniProtKB=T1EPL6 T1EPL6 20198516 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG177891|UniProtKB=T1FCF5 T1FCF5 20206504 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG164215|UniProtKB=T1EV39 T1EV39 20200439 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105994|UniProtKB=T1EDZ1 T1EDZ1 20194793 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176363|UniProtKB=T1FAG2 T1FAG2 20205811 PTHR46512:SF9 PEPTIDYLPROLYL ISOMERASE PEPTIDYLPROLYL ISOMERASE chaperone#PC00072 HELRO|EnsemblGenome=HelroG162594|UniProtKB=T1ESW2 T1ESW2 20199662 PTHR15002:SF0 RIBOSOMAL BIOGENESIS PROTEIN LAS1L RIBOSOMAL BIOGENESIS PROTEIN LAS1L RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG87998|UniProtKB=T1G6X2 T1G6X2 20216819 PTHR10465:SF3 TRANSMEMBRANE GTPASE FZO1 TRANSMEMBRANE GTPASE MARF-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 organelle fusion#GO:0048284;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;mitochondrial fusion#GO:0008053;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;mitochondrion localization#GO:0051646;organelle localization#GO:0051640 mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG93534|UniProtKB=T1G8W4 T1G8W4 20217511 PTHR45746:SF6 LP21163P LP21163P nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG119961|UniProtKB=T1EGP1 T1EGP1 20195741 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787 proteolysis#GO:0006508;metabolic process#GO:0008152;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG170850|UniProtKB=T1F3I3 T1F3I3 20203382 PTHR12112:SF39 BNIP - RELATED EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN) hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG77335|UniProtKB=T1G2W3 T1G2W3 20215411 PTHR45750:SF5 GH11602P HISTONE ACETYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;N-acetyltransferase activity#GO:0008080;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of RNA metabolic process#GO:0051254;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SAGA-type complex#GO:0070461;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123 Notch signaling pathway#P00045>CoA#P01100 HELRO|EnsemblGenome=HelroG165386|UniProtKB=T1EWP6 T1EWP6 20200996 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88618|UniProtKB=T1G744 T1G744 20216891 PTHR11849:SF190 ETS ETS-DOMAIN PROTEIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG90238|UniProtKB=T1G7M9 T1G7M9 20217076 PTHR10093:SF8 IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG IRON-SULFUR CLUSTER ASSEMBLY ENZYME ISCU small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;iron-sulfur cluster binding#GO:0051536;cation binding#GO:0043169;ferrous iron binding#GO:0008198;iron ion binding#GO:0005506 intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592;intracellular iron ion homeostasis#GO:0006879;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 chaperone#PC00072 HELRO|EnsemblGenome=HelroG67135|UniProtKB=T1FYX1 T1FYX1 20214019 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG114692|UniProtKB=T1EG41 T1EG41 20195543 PTHR23273:SF4 REPLICATION FACTOR A 1, RFA1 REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBUNIT telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684;binding#GO:0005488;nucleic acid binding#GO:0003676 telomere organization#GO:0032200;recombinational repair#GO:0000725;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;RNA-templated DNA biosynthetic process#GO:0006278;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;response to stimulus#GO:0050896;cellular component organization#GO:0016043;double-strand break repair via homologous recombination#GO:0000724;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;nucleotide-excision repair#GO:0006289;organelle organization#GO:0006996;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987 replication fork#GO:0005657;replisome#GO:0030894;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG140496|UniProtKB=T1EJ13 T1EJ13 20196563 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular process#GO:0009987;cell-cell signaling#GO:0007267;biological regulation#GO:0065007 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG153385|UniProtKB=T1EL62 T1EL62 20197319 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG172654|UniProtKB=T1F5Q6 T1F5Q6 20204155 PTHR45803:SF5 SOX100B SOX100B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG66967|UniProtKB=T1FYU1 T1FYU1 20213989 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG89250|UniProtKB=T1G7B0 T1G7B0 20216957 PTHR31204:SF1 SIGMA INTRACELLULAR RECEPTOR 2 SIGMA INTRACELLULAR RECEPTOR 2 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of transport#GO:0051049 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG186716|UniProtKB=T1FP25 T1FP25 20210572 PTHR13703:SF61 SMAD PROTEIN MOTHERS AGAINST DPP sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;protein binding#GO:0005515;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to growth factor stimulus#GO:0071363;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 SCW signaling pathway#P06216>MED#P06323;DPP signaling pathway#P06213>MAD#P06288;GBB signaling pathway#P06214>MED#P06299;MYO signaling pathway#P06215>MED#P06311;DPP signaling pathway#P06213>MED#P06279;Wnt signaling pathway#P00057>Smad4#P01455;DPP-SCW signaling pathway#P06212>MAD#P06271;DPP-SCW signaling pathway#P06212>MED#P06265;SCW signaling pathway#P06216>MAD#P06331;ALP23B signaling pathway#P06209>MED#P06221;Activin beta signaling pathway#P06210>MED#P06233;GBB signaling pathway#P06214>MAD#P06305;TGF-beta signaling pathway#P00052>RSmads#P01292;BMP/activin signaling pathway-drosophila#P06211>R-Smad#P06245 HELRO|EnsemblGenome=HelroG169836|UniProtKB=T1F2D0 T1F2D0 20202980 PTHR24403:SF67 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168434|UniProtKB=T1F0L3 T1F0L3 20202363 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG74316|UniProtKB=T1G1P7 T1G1P7 20214995 PTHR11452:SF83 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;metabolic process#GO:0008152;oligosaccharide metabolic process#GO:0009311 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;galactosidase#PC00104 HELRO|EnsemblGenome=HelroG172276|UniProtKB=T1F563 T1F563 20203962 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172833|UniProtKB=T1F5Z6 T1F5Z6 20204245 PTHR11467:SF189 HISTONE H1 HISTONE 24 nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;chromatin DNA binding#GO:0031490 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of DNA recombination#GO:0000018;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185528|UniProtKB=T1FMX7 T1FMX7 20210176 PTHR11105:SF0 CITRATE LYASE SUBUNIT BETA-RELATED CITRAMALYL-COA LYASE, MITOCHONDRIAL catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222 lyase#PC00144 Pyruvate metabolism#P02772>Citrate Lyase#P03137 HELRO|EnsemblGenome=HelroG190416|UniProtKB=T1FRZ3 T1FRZ3 20211590 PTHR12943:SF27 HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950 HELRO|EnsemblGenome=HelroG81227|UniProtKB=T1G4B7 T1G4B7 20215915 PTHR13966:SF19 ENDONUCLEASE RELATED DNA_RNA NON-SPECIFIC ENDONUCLEASE DOMAIN-CONTAINING PROTEIN-RELATED RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520 primary metabolic process#GO:0044238;programmed cell death#GO:0012501;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;execution phase of apoptosis#GO:0097194;cell death#GO:0008219;apoptotic process#GO:0006915;catabolic process#GO:0009056;DNA catabolic process#GO:0006308;cellular component disassembly#GO:0022411;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle membrane#GO:0031090;cytoplasm#GO:0005737;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;nucleus#GO:0005634;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG185273|UniProtKB=T1FML4 T1FML4 20210063 PTHR12734:SF0 METHYLTRANSFERASE-RELATED 18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;rRNA (guanine) methyltransferase activity#GO:0016435;catalytic activity, acting on RNA#GO:0140098;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;rRNA metabolic process#GO:0016072;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nuclear transport#GO:0051169;rRNA processing#GO:0006364;nuclear export#GO:0051168;localization#GO:0051179;ribosome localization#GO:0033750;ribosomal small subunit export from nucleus#GO:0000056;nucleocytoplasmic transport#GO:0006913;organelle localization#GO:0051640;RNA processing#GO:0006396;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribonucleoprotein complex biogenesis#GO:0022613;establishment of organelle localization#GO:0051656;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG191738|UniProtKB=T1FT90 T1FT90 20212037 PTHR23147:SF75 SERINE/ARGININE RICH SPLICING FACTOR RNA-BINDING PROTEIN 1-RELATED membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear speck#GO:0016607;organelle lumen#GO:0043233 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG138932|UniProtKB=T1EIY2 T1EIY2 20196532 PTHR23310:SF77 ACYL-COA-BINDING PROTEIN, ACBP LD25952P heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG163754|UniProtKB=T1EUF1 T1EUF1 20200201 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193253|UniProtKB=T1FUS8 T1FUS8 20212574 PTHR31126:SF1 TYROSINE-PROTEIN PHOSPHATASE TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG181166|UniProtKB=T1FGP7 T1FGP7 20207996 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92884|UniProtKB=T1G8N0 T1G8N0 20217427 PTHR42743:SF11 AMINO-ACID AMINOTRANSFERASE AMINODEOXYCHORISMATE LYASE small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 metabolite interconversion enzyme#PC00262;transaminase#PC00216;transferase#PC00220 Isoleucine biosynthesis#P02748>Branched chain amino acid aminotransferase#P02994;Valine biosynthesis#P02785>Branched chain amino acid aminotransferase#P03215;Alanine biosynthesis#P02724>Branched chain amino acid aminotransferase#P02815;Leucine biosynthesis#P02749>Branched chain amino acid aminotransferase#P03000 HELRO|EnsemblGenome=HelroG78362|UniProtKB=T1G3B0 T1G3B0 20215558 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HB1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG190317|UniProtKB=T1FRW5 T1FRW5 20211562 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN SHIFTED protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 extracellular region#GO:0005576;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG111705|UniProtKB=T1EFD9 T1EFD9 20195291 PTHR14145:SF2 26S PROTESOME SUBUNIT 6 COP9 SIGNALOSOME COMPLEX SUBUNIT 1 cellular process#GO:0009987;regulation of protein stability#GO:0031647;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein stabilization#GO:0050821;regulation of biological quality#GO:0065008;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG112302|UniProtKB=T1EFI4 T1EFI4 20195336 PTHR13923:SF11 SEC31-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC31A cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;COPII-coated vesicle budding#GO:0090114;cellular component organization#GO:0016043 coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG82074|UniProtKB=T1G4M5 T1G4M5 20216023 PTHR45834:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG76894|UniProtKB=T1G2Q7 T1G2Q7 20215355 PTHR10537:SF3 DNA PRIMASE LARGE SUBUNIT DNA PRIMASE LARGE SUBUNIT RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA replication initiation#GO:0006270 intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nuclear replication fork#GO:0043596;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;nuclear DNA-directed RNA polymerase complex#GO:0055029;replisome#GO:0030894;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 primase#PC00189 DNA replication#P00017>Primase#P00528 HELRO|EnsemblGenome=HelroG113568|UniProtKB=T1EFT7 T1EFT7 20195439 PTHR18934:SF91 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16 ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG76253|UniProtKB=T1G2H4 T1G2H4 20215272 PTHR12649:SF29 PEPTIDYL-TRNA HYDROLASE 2 PEPTIDYL-TRNA HYDROLASE hydrolase activity#GO:0016787;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG76689|UniProtKB=T1G2M6 T1G2M6 20215324 PTHR44489:SF11 FAMILY NOT NAMED WD REPEAT DOMAIN 86 HELRO|EnsemblGenome=HelroG84251|UniProtKB=T1G5G4 T1G5G4 20216311 PTHR24068:SF128 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 H ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG173686|UniProtKB=T1F742 T1F742 20204641 PTHR45080:SF8 CONTACTIN 5 NEURAL CELL ADHESION MOLECULE 1 ISOFORM X1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell adhesion#GO:0007155;cell junction organization#GO:0034330;cellular process#GO:0009987;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 axon#GO:0030424;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell body#GO:0044297;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG167362|UniProtKB=T1EZB0 T1EZB0 20201910 PTHR16095:SF11 TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER TRANSMEMBRANE PROTEIN 143 HELRO|EnsemblGenome=HelroG157680|UniProtKB=T1EME5 T1EME5 20197745 PTHR23264:SF19 NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;iron-sulfur cluster assembly#GO:0016226;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG169877|UniProtKB=T1F2E3 T1F2E3 20202993 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189774|UniProtKB=T1FRD2 T1FRD2 20211379 PTHR46424:SF1 UBX DOMAIN-CONTAINING PROTEIN 4 UBX DOMAIN-CONTAINING PROTEIN 4 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168906|UniProtKB=T1F142 T1F142 20202542 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG132750|UniProtKB=T1EHZ4 T1EHZ4 20196194 PTHR32073:SF7 GH11358P GH11358P HELRO|EnsemblGenome=HelroG181976|UniProtKB=T1FHK0 T1FHK0 20208299 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76875|UniProtKB=T1G2Q4 T1G2Q4 20215352 PTHR11003:SF346 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 18 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG176030|UniProtKB=T1FA20 T1FA20 20205669 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG170118|UniProtKB=T1F2N7 T1F2N7 20203086 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG195105|UniProtKB=T1FWR4 T1FWR4 20213259 PTHR24171:SF15 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50-RELATED HELRO|EnsemblGenome=HelroG107319|UniProtKB=T1EE95 T1EE95 20194897 PTHR24034:SF200 EGF-LIKE DOMAIN-CONTAINING PROTEIN FI18763P1-RELATED extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG88858|UniProtKB=T1G771 T1G771 20216918 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG176798|UniProtKB=T1FAX2 T1FAX2 20205971 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 response to stimulus#GO:0050896;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stress#GO:0006950 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG191453|UniProtKB=T1FT01 T1FT01 20211948 PTHR15137:SF9 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367 RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG165793|UniProtKB=T1EXA5 T1EXA5 20201205 PTHR11614:SF198 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;lipase#PC00143 HELRO|EnsemblGenome=HelroG183749|UniProtKB=T1FK50 T1FK50 20209199 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161224|UniProtKB=T1ER84 T1ER84 20199084 PTHR11506:SF35 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5 establishment of localization#GO:0051234;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of protein localization#GO:0045184 lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosome#GO:0005764;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG108518|UniProtKB=T1EEJ7 T1EEJ7 20194999 PTHR46624:SF4 AGAP002036-PA ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1-LIKE ISOFORM X1 ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;phospholipid binding#GO:0005543;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981 cellular component assembly#GO:0022607;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;lipid storage#GO:0019915;cellular component organization or biogenesis#GO:0071840;lipid droplet organization#GO:0034389;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG186199|UniProtKB=T1FNT1 T1FNT1 20210478 PTHR12300:SF161 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG100875|UniProtKB=T1ED18 T1ED18 20194470 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG157880|UniProtKB=T1EMH2 T1EMH2 20197772 PTHR23064:SF32 TROPONIN CALTRACTIN ICL1D actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG169080|UniProtKB=T1F1D5 T1F1D5 20202635 PTHR11214:SF410 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 6 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;galactosyltransferase activity#GO:0008378 glycosaminoglycan metabolic process#GO:0030203;aminoglycan biosynthetic process#GO:0006023;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;glycosaminoglycan biosynthetic process#GO:0006024;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG173956|UniProtKB=T1F7E9 T1F7E9 20204748 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194439|UniProtKB=T1FW20 T1FW20 20213016 PTHR43049:SF1 EARLY ENDOSOME ANTIGEN EARLY ENDOSOME ANTIGEN HELRO|EnsemblGenome=HelroG121944|UniProtKB=T1EGT2 T1EGT2 20195782 PTHR19297:SF192 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3-RELATED glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG79566|UniProtKB=T1G3Q1 T1G3Q1 20215699 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86704|UniProtKB=T1G6F7 T1G6F7 20216654 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154 signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG188309|UniProtKB=T1FPV0 T1FPV0 20210847 PTHR12879:SF8 SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 SPHINGOLIPID DELTA(4)-DESATURASE DES1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 hydroxylase#PC00122;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG158962|UniProtKB=T1ENF8 T1ENF8 20198108 PTHR23220:SF122 INTEGRIN ALPHA INTEGRIN ALPHA-PS1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG165282|UniProtKB=T1EWJ1 T1EWJ1 20200941 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69010|UniProtKB=T1FZN4 T1FZN4 20214282 PTHR11108:SF1 FERROCHELATASE FERROCHELATASE, MITOCHONDRIAL lyase activity#GO:0016829;catalytic activity#GO:0003824 tetrapyrrole biosynthetic process#GO:0033014;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;cellular process#GO:0009987;porphyrin-containing compound biosynthetic process#GO:0006779;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 lyase#PC00144 Heme biosynthesis#P02746>Ferrochelatase#P02972 HELRO|EnsemblGenome=HelroG179894|UniProtKB=T1FF84 T1FF84 20207483 PTHR31004:SF1 TRANSMEMBRANE PROTEIN 79 TRANSMEMBRANE PROTEIN 79 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;secretion by cell#GO:0032940;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179 Golgi apparatus#GO:0005794;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;lysosomal membrane#GO:0005765;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;vacuole#GO:0005773;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG115114|UniProtKB=T1EG67 T1EG67 20195569 PTHR21394:SF0 MAU2 CHROMATID COHESION FACTOR HOMOLOG MAU2 CHROMATID COHESION FACTOR HOMOLOG catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic sister chromatid cohesion#GO:0007064 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG87296|UniProtKB=T1G6N8 T1G6N8 20216735 PTHR24006:SF952 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG175729|UniProtKB=T1F9L2 T1F9L2 20205511 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG158528|UniProtKB=T1EMX1 T1EMX1 20197921 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67216|UniProtKB=T1FYY2 T1FYY2 20214030 PTHR19849:SF0 PHOSPHOLIPASE A-2-ACTIVATING PROTEIN PHOSPHOLIPASE A2 ACTIVATOR PROTEIN, ISOFORM A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;process utilizing autophagic mechanism#GO:0061919;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;autophagy#GO:0006914;macroautophagy#GO:0016236;proteasomal protein catabolic process#GO:0010498 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185407|UniProtKB=T1FMS0 T1FMS0 20210119 PTHR45806:SF1 SYNAPTOBREVIN HOMOLOG YKT6 SYNAPTOBREVIN HOMOLOG YKT6 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 vacuole fusion, non-autophagic#GO:0042144;organelle membrane fusion#GO:0090174;macroautophagy#GO:0016236;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;autophagy#GO:0006914;organelle organization#GO:0006996;membrane fusion#GO:0061025;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;metabolic process#GO:0008152;vesicle fusion#GO:0006906;catabolic process#GO:0009056;intra-Golgi vesicle-mediated transport#GO:0006891;cellular component organization#GO:0016043;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;localization#GO:0051179;vacuole fusion#GO:0097576 organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;autophagosome#GO:0005776;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG158315|UniProtKB=T1EMM9 T1EMM9 20197829 PTHR13802:SF52 MUCIN 4-RELATED NIDOGEN-RELATED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG164700|UniProtKB=T1EVQ9 T1EVQ9 20200659 PTHR19871:SF14 BETA TRANSDUCIN-RELATED PROTEIN NACHT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70757|UniProtKB=T1G0B8 T1G0B8 20214516 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG71534|UniProtKB=T1G0M9 T1G0M9 20214627 PTHR12308:SF83 ANOCTAMIN ANOCTAMIN molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;intramembrane lipid carrier activity#GO:0140303 cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;phospholipid transport#GO:0015914;membrane organization#GO:0061024;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG62499|UniProtKB=T1FX15 T1FX15 20213363 PTHR10336:SF80 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN C2 DOMAIN-CONTAINING PROTEIN lipase activity#GO:0016298;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 transport#GO:0006810;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;establishment of localization#GO:0051234;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;metabolic process#GO:0008152;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;signal transduction#GO:0007165;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG103503|UniProtKB=T1EDG5 T1EDG5 20194617 PTHR14145:SF1 26S PROTESOME SUBUNIT 6 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG79619|UniProtKB=T1G3R2 T1G3R2 20215710 PTHR43134:SF1 SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 establishment of protein localization#GO:0045184;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein targeting to ER#GO:0045047;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;protein targeting#GO:0006605;establishment of localization#GO:0051234 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 G-protein#PC00020;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG173437|UniProtKB=T1F6T7 T1F6T7 20204536 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;trans-synaptic signaling#GO:0099537 monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG83131|UniProtKB=T1G507 T1G507 20216155 PTHR12611:SF0 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG70830|UniProtKB=T1G0C8 T1G0C8 20214526 PTHR16777:SF2 PROTEIN ECT2 PROTEIN ECT2 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 cytoskeleton-dependent cytokinesis#GO:0061640;mitotic cell cycle process#GO:1903047;cytokinesis#GO:0000910;mitotic cell cycle#GO:0000278;mitotic cytokinesis#GO:0000281;cell cycle#GO:0007049;cell cycle process#GO:0022402;cell division#GO:0051301;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cell periphery#GO:0071944;nucleus#GO:0005634;cell cortex#GO:0005938 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG175447|UniProtKB=T1F996 T1F996 20205395 PTHR15065:SF4 INSULINOMA-ASSOCIATED 1 LD18634P sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;nervous system development#GO:0007399;regulation of cell cycle process#GO:0010564;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;neuron differentiation#GO:0030182 intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG65942|UniProtKB=T1FYE7 T1FYE7 20213845 PTHR11849:SF302 ETS ETS DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG174730|UniProtKB=T1F8E9 T1F8E9 20205098 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED PROTEIN NSUN7 HELRO|EnsemblGenome=HelroG173478|UniProtKB=T1F6V3 T1F6V3 20204552 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG172535|UniProtKB=T1F5H3 T1F5H3 20204072 PTHR23322:SF1 FAS-ASSOCIATED PROTEIN FAS-ASSOCIATED FACTOR 2 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66381|UniProtKB=T1FYK4 T1FYK4 20213902 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG193611|UniProtKB=T1FV65 T1FV65 20212711 PTHR15415:SF7 MITOFILIN MICOS COMPLEX SUBUNIT MIC60 HELRO|EnsemblGenome=HelroG177701|UniProtKB=T1FC37 T1FC37 20206386 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG80823|UniProtKB=T1G460 T1G460 20215858 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG157641|UniProtKB=T1EME3 T1EME3 20197743 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING IP01257P-RELATED DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG185198|UniProtKB=T1FMH9 T1FMH9 20210028 PTHR13483:SF11 BOX C_D SNORNA PROTEIN 1-RELATED ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG163757|UniProtKB=T1EUF4 T1EUF4 20200204 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG120145|UniProtKB=T1EGP6 T1EGP6 20195746 PTHR24345:SF99 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010 centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG91092|UniProtKB=T1G7Z7 T1G7Z7 20217194 PTHR43220:SF18 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 41B macroautophagy#GO:0016236;cellular component assembly#GO:0022607;catabolic process#GO:0009056;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;process utilizing autophagic mechanism#GO:0061919;autophagosome assembly#GO:0000045;vacuole organization#GO:0007033;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;metabolic process#GO:0008152 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HELRO|EnsemblGenome=HelroG171749|UniProtKB=T1F4L7 T1F4L7 20203766 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG185689|UniProtKB=T1FN55 T1FN55 20210253 PTHR21824:SF4 TRANSMEMBRANE PROTEIN 177 TRANSMEMBRANE PROTEIN 177 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG169959|UniProtKB=T1F2H2 T1F2H2 20203022 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190729|UniProtKB=T1FS89 T1FS89 20211686 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73211|UniProtKB=T1G1B8 T1G1B8 20214866 PTHR12760:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2 membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184 organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796 chaperone#PC00072 HELRO|EnsemblGenome=HelroG101030|UniProtKB=T1ED26 T1ED26 20194478 PTHR11986:SF126 AMINOTRANSFERASE CLASS III ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;arginine metabolic process#GO:0006525;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739 transaminase#PC00216 HELRO|EnsemblGenome=HelroG189657|UniProtKB=T1FR85 T1FR85 20211332 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG73540|UniProtKB=T1G1F5 T1G1F5 20214903 PTHR21222:SF2 MIT DOMAIN-CONTAINING PROTEIN 1 FI11682P-RELATED HELRO|EnsemblGenome=HelroG179476|UniProtKB=T1FER6 T1FER6 20207315 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184139|UniProtKB=T1FKN5 T1FKN5 20209384 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84805|UniProtKB=T1G5N8 T1G5N8 20216385 PTHR11306:SF0 NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED LP08842P-RELATED binding#GO:0005488;sterol binding#GO:0032934;lipid binding#GO:0008289;steroid binding#GO:0005496 macromolecule localization#GO:0033036;lipid transport#GO:0006869;transport#GO:0006810;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;sterol transport#GO:0015918;establishment of localization#GO:0051234;localization#GO:0051179 HELRO|EnsemblGenome=HelroG81484|UniProtKB=T1G4F0 T1G4F0 20215948 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773 positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;nervous system development#GO:0007399;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;multicellular organism development#GO:0007275;regulation of programmed cell death#GO:0043067;positive regulation of cell population proliferation#GO:0008284;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;ERBB signaling pathway#GO:0038127;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG192664|UniProtKB=T1FU62 T1FU62 20212358 PTHR10183:SF382 CALPAIN CALPAIN-15 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG187239|UniProtKB=T1FP82 T1FP82 20210629 PTHR43380:SF1 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 oxidoreductase complex#GO:1990204;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190267|UniProtKB=T1FRU2 T1FRU2 20211539 PTHR22957:SF661 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN GH16847P molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG105555|UniProtKB=T1EDW2 T1EDW2 20194764 PTHR19308:SF8 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG87238|UniProtKB=T1G6N3 T1G6N3 20216730 PTHR10127:SF911 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;proteolysis#GO:0006508;pattern specification process#GO:0007389;primary metabolic process#GO:0044238;dorsal/ventral pattern formation#GO:0009953;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regionalization#GO:0003002;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 SCW signaling pathway#P06216>TLD#P06327;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP signaling pathway#P06213>TLD#P06283;BMP/activin signaling pathway-drosophila#P06211>TLD#P06249;DPP-SCW signaling pathway#P06212>TLD#P06264 HELRO|EnsemblGenome=HelroG185682|UniProtKB=T1FN51 T1FN51 20210249 PTHR24012:SF935 RNA BINDING PROTEIN LD36772P-RELATED poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG72974|UniProtKB=T1G182 T1G182 20214830 PTHR45636:SF56 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED EYEGONE, ISOFORM A-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG71773|UniProtKB=T1G0R4 T1G0R4 20214662 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594 chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG65497|UniProtKB=T1FY87 T1FY87 20213785 PTHR46961:SF17 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG67965|UniProtKB=T1FZ87 T1FZ87 20214135 PTHR46212:SF10 PEFLIN PEFLIN establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;COPII-coated vesicle budding#GO:0090114;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641 HELRO|EnsemblGenome=HelroG160471|UniProtKB=T1EQA5 T1EQA5 20198755 PTHR12461:SF100 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED JMJC DOMAIN-CONTAINING PROTEIN 4 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159817|UniProtKB=T1EPF8 T1EPF8 20198458 PTHR10221:SF22 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;transcription by RNA polymerase II#GO:0006366;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170 histone acetyltransferase complex#GO:0000123;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;SAGA complex#GO:0000124;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;acetyltransferase complex#GO:1902493;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transferase complex#GO:1990234;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;peptidase complex#GO:1905368;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;SAGA-type complex#GO:0070461;nuclear DNA-directed RNA polymerase complex#GO:0055029;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG188838|UniProtKB=T1FQE7 T1FQE7 20211044 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum membrane organization#GO:0090158;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG185413|UniProtKB=T1FMS4 T1FMS4 20210123 PTHR45758:SF4 MITOFERRIN-1-RELATED MITOFERRIN-1 iron ion transmembrane transporter activity#GO:0005381;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;transition metal ion transmembrane transporter activity#GO:0046915;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 iron ion transmembrane transport#GO:0034755;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG109564|UniProtKB=T1EEU9 T1EEU9 20195101 PTHR10335:SF28 RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN RRNA 2'-O-METHYLTRANSFERASE FIBRILLARIN catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;histone modifying activity#GO:0140993;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;binding#GO:0005488;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on a rRNA#GO:0140102;RNA binding#GO:0003723;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;nucleic acid binding#GO:0003676 macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG158927|UniProtKB=T1ENF0 T1ENF0 20198100 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP-TYPE DOMAIN-CONTAINING PROTEIN zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG191643|UniProtKB=T1FT59 T1FT59 20212006 PTHR34487:SF1 ACYL-ACP THIOESTERASE ACYL-ACP THIOESTERASE HELRO|EnsemblGenome=HelroG95841|UniProtKB=T1G981 T1G981 20217628 PTHR45720:SF10 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic anion channel activity#GO:0008308;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253 monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG84140|UniProtKB=T1G5F3 T1G5F3 20216300 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG83602|UniProtKB=T1G581 T1G581 20216228 PTHR12297:SF21 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN-CONTAINING PROTEIN cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190245|UniProtKB=T1FRT2 T1FRT2 20211529 PTHR16212:SF4 FOCADHESIN FAMILY MEMBER FOCADHESIN HELRO|EnsemblGenome=HelroG70153|UniProtKB=T1G030 T1G030 20214428 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG184213|UniProtKB=T1FKS1 T1FKS1 20209420 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167077|UniProtKB=T1EYZ6 T1EYZ6 20201796 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG161124|UniProtKB=T1ER42 T1ER42 20199042 PTHR14418:SF5 CONDENSIN COMPLEX SUBUNIT 3-RELATED CONDENSIN COMPLEX SUBUNIT 3 nuclear division#GO:0000280;organelle fission#GO:0048285;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;condensin complex#GO:0000796;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG76588|UniProtKB=T1G2L8 T1G2L8 20215316 PTHR23115:SF36 TRANSLATION FACTOR G1 TO S PHASE TRANSITION 2 ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 gene expression#GO:0010467;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;protein-containing complex disassembly#GO:0032984;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;translational termination#GO:0006415;translation#GO:0006412 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation factor#PC00223 HELRO|EnsemblGenome=HelroG190783|UniProtKB=T1FSA5 T1FSA5 20211702 PTHR10663:SF372 GUANYL-NUCLEOTIDE EXCHANGE FACTOR F-BOX ONLY PROTEIN 8 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG193054|UniProtKB=T1FUK7 T1FUK7 20212503 PTHR10671:SF116 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG175082|UniProtKB=T1F8U0 T1F8U0 20205239 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170574|UniProtKB=T1F371 T1F371 20203270 PTHR14948:SF25 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190418|UniProtKB=T1FRZ4 T1FRZ4 20211591 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG104028|UniProtKB=T1EDJ2 T1EDJ2 20194644 PTHR19375:SF144 HEAT SHOCK PROTEIN 70KDA ENDOPLASMIC RETICULUM CHAPERONE BIP ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;protein binding#GO:0005515;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111 protein refolding#GO:0042026;response to unfolded protein#GO:0006986;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;protein folding#GO:0006457;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;gene expression#GO:0010467;protein maturation#GO:0051604;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;protein metabolic process#GO:0019538;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;endoplasmic reticulum unfolded protein response#GO:0030968 organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum lumen#GO:0005788;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534 chaperone#PC00072;Hsp70 family chaperone#PC00027 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG116543|UniProtKB=T1EGF9 T1EGF9 20195661 PTHR46189:SF1 LD41958P LD41958P intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG177393|UniProtKB=T1FBM0 T1FBM0 20206219 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG182479|UniProtKB=T1FI92 T1FI92 20208541 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162879|UniProtKB=T1ETB1 T1ETB1 20199811 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG194910|UniProtKB=T1FWJ9 T1FWJ9 20213194 PTHR11232:SF17 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER CAPON-LIKE PROTEIN signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;neuron projection#GO:0043005;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axon#GO:0030424;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165697|UniProtKB=T1EX65 T1EX65 20201165 PTHR16172:SF41 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG93295|UniProtKB=T1G8V0 T1G8V0 20217497 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166 microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278 organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 tubulin#PC00228;cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HELRO|EnsemblGenome=HelroG173483|UniProtKB=T1F6V5 T1F6V5 20204554 PTHR21035:SF2 28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS26 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG159973|UniProtKB=T1EPL9 T1EPL9 20198519 PTHR21838:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 137 COILED-COIL DOMAIN-CONTAINING PROTEIN 137 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG105094|UniProtKB=T1EDQ7 T1EDQ7 20194709 PTHR48498:SF1 FAMILY NOT NAMED RETROVIRUS-RELATED POL POLYPROTEIN FROM TYPE-1 RETROTRANSPOSABLE ELEMENT R1-LIKE PROTEIN HELRO|EnsemblGenome=HelroG64272|UniProtKB=T1FXS1 T1FXS1 20213619 PTHR43716:SF6 D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG175273|UniProtKB=T1F931 T1F931 20205330 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186210|UniProtKB=T1FNT7 T1FNT7 20210484 PTHR11669:SF5 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;replication fork#GO:0005657;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG180636|UniProtKB=T1FG40 T1FG40 20207789 PTHR46538:SF3 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76189|UniProtKB=T1G2G5 T1G2G5 20215263 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG161625|UniProtKB=T1ERQ2 T1ERQ2 20199252 PTHR23249:SF16 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234 vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192303|UniProtKB=T1FTT2 T1FTT2 20212229 PTHR14186:SF20 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED IGFBP DOMAIN-CONTAINING PROTEIN ISOFORM X1 molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG184490|UniProtKB=T1FLB2 T1FLB2 20209611 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG148469|UniProtKB=T1EK90 T1EK90 20196990 PTHR24333:SF19 HOMEO BOX HB9 LIKE A-RELATED BRAIN-SPECIFIC HOMEOBOX PROTEIN HOMOLOG helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG180594|UniProtKB=T1FG28 T1FG28 20207777 PTHR13099:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193319|UniProtKB=T1FUV7 T1FUV7 20212603 PTHR21228:SF74 FAST LEU-RICH DOMAIN-CONTAINING LD32258P RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;post-transcriptional regulation of gene expression#GO:0010608;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;regulation of RNA stability#GO:0043487;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;regulation of RNA metabolic process#GO:0051252;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of mRNA metabolic process#GO:1903311;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG191301|UniProtKB=T1FSV1 T1FSV1 20211898 PTHR45931:SF3 SI:CH211-59O9.10 RING ZINC FINGER-CONTAINING PROTEIN ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG77621|UniProtKB=T1G310 T1G310 20215458 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG167837|UniProtKB=T1EZV0 T1EZV0 20202100 PTHR33447:SF2 GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755 cellular response to chemical stimulus#GO:0070887;cellular detoxification#GO:1990748;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;response to cadmium ion#GO:0046686;metabolic process#GO:0008152;response to metal ion#GO:0010038;detoxification of inorganic compound#GO:0061687;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;biosynthetic process#GO:0009058;detoxification#GO:0098754 HELRO|EnsemblGenome=HelroG70793|UniProtKB=T1G0C2 T1G0C2 20214520 PTHR10412:SF11 MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE alpha-glucosidase activity#GO:0090599;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;glucosidase activity#GO:0015926 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 glucosidase#PC00108;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG84874|UniProtKB=T1G5P9 T1G5P9 20216396 PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032;CCKR signaling map#P06959>MEF2D#P07048 HELRO|EnsemblGenome=HelroG153248|UniProtKB=T1EL15 T1EL15 20197268 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165385|UniProtKB=T1EWP5 T1EWP5 20200995 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173799|UniProtKB=T1F787 T1F787 20204686 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105246|UniProtKB=T1EDS1 T1EDS1 20194723 PTHR24155:SF11 OSTEOCLAST-STIMULATING FACTOR 1 CASKIN, ISOFORM B signaling adaptor activity#GO:0035591;protein binding#GO:0005515;binding#GO:0005488;phosphatase binding#GO:0019902;protein-macromolecule adaptor activity#GO:0030674;enzyme binding#GO:0019899;protein phosphatase binding#GO:0019903;molecular adaptor activity#GO:0060090 multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon development#GO:0061564;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 axon#GO:0030424;cell junction#GO:0030054;anchoring junction#GO:0070161;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;cell projection#GO:0042995;focal adhesion#GO:0005925;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG112655|UniProtKB=T1EFL1 T1EFL1 20195363 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED potassium ion transmembrane transporter activity#GO:0015079;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG104068|UniProtKB=T1EDJ4 T1EDJ4 20194646 PTHR12913:SF1 UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN COLD SHOCK DOMAIN-CONTAINING PROTEIN E1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-RNA adaptor activity#GO:0140517 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253 cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG69747|UniProtKB=T1FZY2 T1FZY2 20214380 PTHR22883:SF40 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 protein targeting to membrane#GO:0006612;protein localization to cell periphery#GO:1990778;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of signaling#GO:0023051;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;protein targeting#GO:0006605;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183810|UniProtKB=T1FK83 T1FK83 20209232 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG99711|UniProtKB=T1G9U6 T1G9U6 20217842 PTHR10288:SF347 KH DOMAIN CONTAINING RNA BINDING PROTEIN MUSHROOM-BODY EXPRESSED, ISOFORM K RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167215|UniProtKB=T1EZ55 T1EZ55 20201855 PTHR13906:SF14 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 5 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphatidylcholine biosynthetic process#GO:0006656;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;lipid modification#GO:0030258 cellular anatomical structure#GO:0110165;membrane#GO:0016020 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG85090|UniProtKB=T1G5S6 T1G5S6 20216423 PTHR11451:SF46 THREONINE-TRNA LIGASE THREONINE--TRNA LIGASE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG165967|UniProtKB=T1EXI5 T1EXI5 20201285 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG147202|UniProtKB=T1EJX8 T1EJX8 20196878 PTHR11829:SF380 FORKHEAD BOX PROTEIN PROTEIN FORK HEAD RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG108840|UniProtKB=T1EEM9 T1EEM9 20195031 PTHR46070:SF1 PINSTRIPE, ISOFORM A PINSTRIPE, ISOFORM A enzyme binding#GO:0019899;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 HELRO|EnsemblGenome=HelroG185089|UniProtKB=T1FMD7 T1FMD7 20209986 PTHR21252:SF3 TB1 PROTEIN-RELATED FI08023P-RELATED mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;mitochondrial fission#GO:0000266;organelle fission#GO:0048285;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 HELRO|EnsemblGenome=HelroG74793|UniProtKB=T1G1V8 T1G1V8 20215056 PTHR15722:SF2 IFT140/172-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG microtubule-based transport#GO:0099111;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705 cilium#GO:0005929;intracellular organelle#GO:0043229;intraciliary transport particle#GO:0030990;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intraciliary transport particle B#GO:0030992;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991 structural protein#PC00211 HELRO|EnsemblGenome=HelroG76744|UniProtKB=T1G2N8 T1G2N8 20215336 PTHR24058:SF103 DUAL SPECIFICITY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG145315|UniProtKB=T1EJK0 T1EJK0 20196750 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173370|UniProtKB=T1F6Q6 T1F6Q6 20204505 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 FGF signaling pathway#P00021>RKIP#P00630;EGF receptor signaling pathway#P00018>RKIP#P00548 HELRO|EnsemblGenome=HelroG173560|UniProtKB=T1F6Z2 T1F6Z2 20204591 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG145872|UniProtKB=T1EJN6 T1EJN6 20196786 PTHR24388:SF118 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 507 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG162994|UniProtKB=T1ETI6 T1ETI6 20199886 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96420|UniProtKB=T1G9C0 T1G9C0 20217667 PTHR22847:SF637 WD40 REPEAT PROTEIN WD40 REPEAT-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG172251|UniProtKB=T1F560 T1F560 20203959 PTHR46557:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10 enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;protein phosphatase binding#GO:0019903;protein binding#GO:0005515 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;chromosome#GO:0005694 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG171012|UniProtKB=T1F3P6 T1F3P6 20203445 PTHR22878:SF63 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN HEAVY CHAIN 10, AXONEMAL Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG170722|UniProtKB=T1F3D0 T1F3D0 20203329 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173001|UniProtKB=T1F692 T1F692 20204341 PTHR24336:SF8 TRANSCRIPTION FACTOR LBX LADYBIRD EARLY-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG169582|UniProtKB=T1F248 T1F248 20202898 PTHR47167:SF4 SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN SERINE_THREONINE-PROTEIN KINASE TAO catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of JNK cascade#GO:0046328;positive regulation of MAPK cascade#GO:0043410;regulation of response to stress#GO:0080134;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG88429|UniProtKB=T1G724 T1G724 20216871 PTHR46505:SF1 OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1 OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG120022|UniProtKB=T1EGP3 T1EGP3 20195743 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG86050|UniProtKB=T1G666 T1G666 20216563 PTHR45638:SF7 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133 HELRO|EnsemblGenome=HelroG165272|UniProtKB=T1EWI9 T1EWI9 20200939 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG183644|UniProtKB=T1FJZ5 T1FJZ5 20209144 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG114122|UniProtKB=T1EFZ2 T1EFZ2 20195494 PTHR10288:SF234 KH DOMAIN CONTAINING RNA BINDING PROTEIN FAR UPSTREAM ELEMENT-BINDING PROTEIN 3 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG102867|UniProtKB=T1EDC6 T1EDC6 20194578 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;export from cell#GO:0140352;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;potassium ion homeostasis#GO:0055075;localization#GO:0051179;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG191622|UniProtKB=T1FT50 T1FT50 20211997 PTHR31281:SF3 PROTEIN FAM219A PROTEIN FAM219A HELRO|EnsemblGenome=HelroG76708|UniProtKB=T1G2M9 T1G2M9 20215327 PTHR11662:SF279 SOLUTE CARRIER FAMILY 17 VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9 organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;localization#GO:0051179;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;transport#GO:0006810 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG78675|UniProtKB=T1G3E4 T1G3E4 20215592 PTHR23235:SF165 KRUEPPEL-LIKE TRANSCRIPTION FACTOR FI01014P-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG161833|UniProtKB=T1ERY6 T1ERY6 20199336 PTHR33150:SF1 EXTRACELLULAR MATRIX-BINDING PROTEIN EBH EXTRACELLULAR MATRIX-BINDING PROTEIN EBH nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 HELRO|EnsemblGenome=HelroG164963|UniProtKB=T1EW08 T1EW08 20200758 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG165434|UniProtKB=T1EWS4 T1EWS4 20201024 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG191734|UniProtKB=T1FT88 T1FT88 20212035 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85499|UniProtKB=T1G5Y1 T1G5Y1 20216478 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 ligase#PC00142 HELRO|EnsemblGenome=HelroG95426|UniProtKB=T1G958 T1G958 20217605 PTHR13016:SF0 AMMECR1 HOMOLOG AMME SYNDROME CANDIDATE GENE 1 PROTEIN HELRO|EnsemblGenome=HelroG179707|UniProtKB=T1FF18 T1FF18 20207417 PTHR21181:SF13 ER membrane protein complex subunit 5-related NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6 HELRO|EnsemblGenome=HelroG159814|UniProtKB=T1EPF5 T1EPF5 20198455 PTHR22769:SF56 MUTT/NUDIX HYDROLASE 8-OXO-DGDP PHOSPHATASE NUDT18 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193210|UniProtKB=T1FUR4 T1FUR4 20212560 PTHR22775:SF51 SORTING NEXIN SORTING NEXIN-13 anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167 intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS-PX1#P00706 HELRO|EnsemblGenome=HelroG87686|UniProtKB=T1G6U2 T1G6U2 20216789 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;calcium/calmodulin-dependent protein kinase activity#GO:0004683;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG162077|UniProtKB=T1ES82 T1ES82 20199432 PTHR46770:SF1 HOMEOBOX PROTEIN ORTHOPEDIA HOMEOBOX PROTEIN ORTHOPEDIA DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 developmental process#GO:0032502;neuron differentiation#GO:0030182;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;cellular process#GO:0009987;nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG175174|UniProtKB=T1F8Y8 T1F8Y8 20205287 PTHR10938:SF9 TRANSLATION INITIATION FACTOR IF-3 TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG178118|UniProtKB=T1FCR8 T1FCR8 20206617 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188439|UniProtKB=T1FPZ6 T1FPZ6 20210893 PTHR23339:SF129 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE CELL DIVISION CYCLE 14, ISOFORM A hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;cytoskeleton organization#GO:0007010;positive regulation of cell cycle#GO:0045787;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell projection assembly#GO:0030031;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium organization#GO:0044782;regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;regulation of cell cycle#GO:0051726;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;regulation of cell cycle phase transition#GO:1901987;cellular component organization#GO:0016043;cilium assembly#GO:0060271 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;membraneless organelle#GO:0043228 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110956|UniProtKB=T1EF66 T1EF66 20195218 PTHR16288:SF0 WD40 REPEAT PROTEIN 4 TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4 RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG129899|UniProtKB=T1EHS7 T1EHS7 20196127 PTHR24347:SF427 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK3 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG85890|UniProtKB=T1G639 T1G639 20216536 PTHR11761:SF8 50S/60S RIBOSOMAL PROTEIN L14/L23 LARGE RIBOSOMAL SUBUNIT PROTEIN UL14 binding#GO:0005488;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162249|UniProtKB=T1ESE8 T1ESE8 20199498 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65312|UniProtKB=T1FY58 T1FY58 20213756 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG101069|UniProtKB=T1ED29 T1ED29 20194481 PTHR11620:SF2 60S RIBOSOMAL PROTEIN L23A LARGE RIBOSOMAL SUBUNIT PROTEIN UL23 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG164779|UniProtKB=T1EVT0 T1EVT0 20200680 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170469|UniProtKB=T1F337 T1F337 20203236 PTHR19290:SF160 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 15 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG159230|UniProtKB=T1ENS0 T1ENS0 20198220 PTHR15272:SF0 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG116952|UniProtKB=T1EGI7 T1EGI7 20195689 PTHR11524:SF16 60S RIBOSOMAL PROTEIN L7 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30 structural molecule activity#GO:0005198;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG63613|UniProtKB=T1FXI3 T1FXI3 20213531 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG114944|UniProtKB=T1EG55 T1EG55 20195557 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG135208|UniProtKB=T1EI73 T1EI73 20196273 PTHR47979:SF53 DRAB11-RELATED FI07418P guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG115766|UniProtKB=T1EGA3 T1EGA3 20195605 PTHR23280:SF34 4.1 G PROTEIN FERM DOMAIN-CONTAINING PROTEIN actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG155753|UniProtKB=T1ELL9 T1ELL9 20197469 PTHR12882:SF1 SUPPRESSOR OF TY 4 TRANSCRIPTION ELONGATION FACTOR SPT4 RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;binding#GO:0005488 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG62052|UniProtKB=T1FWU8 T1FWU8 20213296 PTHR13563:SF13 TRNA (GUANINE-9-) METHYLTRANSFERASE TRNA (GUANINE(9)-N(1))-METHYLTRANSFERASE TRMT10A RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184858|UniProtKB=T1FM34 T1FM34 20209883 PTHR11604:SF0 PROFILIN PROFILIN protein binding#GO:0005515;binding#GO:0005488;actin monomer binding#GO:0003785;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 cell periphery#GO:0071944;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HELRO|EnsemblGenome=HelroG185607|UniProtKB=T1FN12 T1FN12 20210211 PTHR13293:SF6 AKIRIN-RELATED AKIRIN-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of RNA metabolic process#GO:0051254;regulation of response to biotic stimulus#GO:0002831;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of response to biotic stimulus#GO:0002833;regulation of gene expression#GO:0010468;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;positive regulation of response to external stimulus#GO:0032103;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG101841|UniProtKB=T1ED73 T1ED73 20194525 PTHR45963:SF2 RE52028P SORTING NEXIN-3 HELRO|EnsemblGenome=HelroG190258|UniProtKB=T1FRT7 T1FRT7 20211534 PTHR13091:SF0 AMPLIFIED IN BREAST CANCER 2-RELATED NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8 regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184 HELRO|EnsemblGenome=HelroG124858|UniProtKB=T1EH32 T1EH32 20195882 PTHR14549:SF2 TRANSMEMBRANE PROTEIN 223 TRANSMEMBRANE PROTEIN 223 HELRO|EnsemblGenome=HelroG159136|UniProtKB=T1ENM9 T1ENM9 20198179 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160061|UniProtKB=T1EPQ6 T1EPQ6 20198556 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193068|UniProtKB=T1FUL3 T1FUL3 20212509 PTHR43377:SF2 BILIVERDIN REDUCTASE A BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG177747|UniProtKB=T1FC66 T1FC66 20206415 PTHR23309:SF58 3-HYDROXYACYL-COA DEHYROGENASE 3-HYDROXYACYL-COA DEHYDROGENASE NAD BINDING DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG91248|UniProtKB=T1G819 T1G819 20217216 PTHR13476:SF0 CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6 CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123 HELRO|EnsemblGenome=HelroG161869|UniProtKB=T1ERZ5 T1ERZ5 20199345 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78521|UniProtKB=T1G3C6 T1G3C6 20215574 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG70492|UniProtKB=T1G071 T1G071 20214469 PTHR11414:SF21 CYSTATIN FAMILY MEMBER CYSTATIN 14B, TANDEM DUPLICATE 2-RELATED endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG165867|UniProtKB=T1EXD7 T1EXD7 20201237 PTHR46447:SF1 INTERLEUKIN ENHANCER-BINDING FACTOR INTERLEUKIN ENHANCER-BINDING FACTOR 2 nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG185717|UniProtKB=T1FN69 T1FN69 20210267 PTHR10031:SF0 ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL ATPASE PROTEIN 9 ATP synthase#PC00002;transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG180048|UniProtKB=T1FFE3 T1FFE3 20207542 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86622|UniProtKB=T1G6E4 T1G6E4 20216641 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG174576|UniProtKB=T1F897 T1F897 20205046 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG178944|UniProtKB=T1FDX8 T1FDX8 20207027 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188972|UniProtKB=T1FQI8 T1FQI8 20211085 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG129502|UniProtKB=T1EHR6 T1EHR6 20196116 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion homeostasis#GO:0055074;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG186007|UniProtKB=T1FNJ6 T1FNJ6 20210393 PTHR13273:SF14 ANAMORSIN ANAMORSIN iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG110447|UniProtKB=T1EF21 T1EF21 20195173 PTHR48012:SF16 STERILE20-LIKE KINASE, ISOFORM B-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;cellular response to osmotic stress#GO:0071470;signaling#GO:0023052;hyperosmotic response#GO:0006972;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;cellular response to chemical stress#GO:0062197;cellular response to abiotic stimulus#GO:0071214;response to osmotic stress#GO:0006970;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG189221|UniProtKB=T1FQT5 T1FQT5 20211182 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185556|UniProtKB=T1FMZ3 T1FMZ3 20210192 PTHR23055:SF201 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG161213|UniProtKB=T1ER79 T1ER79 20199079 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG168229|UniProtKB=T1F0C2 T1F0C2 20202272 PTHR23382:SF34 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;oxoacid metabolic process#GO:0043436;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 dehydrogenase#PC00092 TCA cycle#P00051>Malate Dehydrogenase#P01270 HELRO|EnsemblGenome=HelroG79299|UniProtKB=T1G3M3 T1G3M3 20215671 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 RNA processing factor#PC00147;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG92351|UniProtKB=T1G8E7 T1G8E7 20217344 PTHR46473:SF30 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN transmembrane transporter binding#GO:0044325;transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;channel regulator activity#GO:0016247;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;molecular function activator activity#GO:0140677;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 HELRO|EnsemblGenome=HelroG179678|UniProtKB=T1FF08 T1FF08 20207407 PTHR12483:SF27 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN transition metal ion transmembrane transporter activity#GO:0046915;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324 transition metal ion transport#GO:0000041;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;copper ion transmembrane transport#GO:0035434 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG167437|UniProtKB=T1EZD5 T1EZD5 20201935 PTHR21533:SF19 LEUCINE-RICH PROTEIN LEUCINE-RICH PROTEIN HELRO|EnsemblGenome=HelroG87059|UniProtKB=T1G6L2 T1G6L2 20216709 PTHR42943:SF2 GLUTATHIONE S-TRANSFERASE KAPPA GLUTATHIONE S-TRANSFERASE KAPPA 1 transferase#PC00220 HELRO|EnsemblGenome=HelroG190923|UniProtKB=T1FSF2 T1FSF2 20211749 PTHR24006:SF888 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG80870|UniProtKB=T1G466 T1G466 20215864 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG77533|UniProtKB=T1G2Z5 T1G2Z5 20215443 PTHR13348:SF0 RIBONUCLEASE P SUBUNIT P29 RIBONUCLEASE P PROTEIN SUBUNIT P29 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 ribonuclease MRP complex#GO:0000172;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;ribonuclease P complex#GO:0030677;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG161770|UniProtKB=T1ERW2 T1ERW2 20199312 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159227|UniProtKB=T1ENR7 T1ENR7 20198217 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG108086|UniProtKB=T1EEF2 T1EEF2 20194954 PTHR44489:SF11 FAMILY NOT NAMED WD REPEAT DOMAIN 86 HELRO|EnsemblGenome=HelroG162503|UniProtKB=T1ESR5 T1ESR5 20199615 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG123056|UniProtKB=T1EGW7 T1EGW7 20195817 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043 neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;leading edge membrane#GO:0031256;neuron projection membrane#GO:0032589;cell projection membrane#GO:0031253 HELRO|EnsemblGenome=HelroG124468|UniProtKB=T1EH16 T1EH16 20195866 PTHR11662:SF465 SOLUTE CARRIER FAMILY 17 SIALIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG168769|UniProtKB=T1F0Y1 T1F0Y1 20202481 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62284|UniProtKB=T1FWY6 T1FWY6 20213334 PTHR11254:SF429 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SU(DX) ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157401|UniProtKB=T1EMB0 T1EMB0 20197710 PTHR11124:SF12 VACUOLAR SORTING PROTEIN VPS29 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147 membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;retromer complex#GO:0030904;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG182789|UniProtKB=T1FIQ7 T1FIQ7 20208706 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191662|UniProtKB=T1FT69 T1FT69 20212016 PTHR46218:SF4 LASP LIM AND SH3 DOMAIN PROTEIN LASP actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG73300|UniProtKB=T1G1C6 T1G1C6 20214874 PTHR24346:SF119 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE SIK3 HOMOLOG-RELATED protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173142|UniProtKB=T1F6G1 T1F6G1 20204410 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG108097|UniProtKB=T1EEF4 T1EEF4 20194956 PTHR21351:SF0 BARDET-BIEDL SYNDROME PROTEIN 5 BBSOME COMPLEX MEMBER BBS5 lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;binding#GO:0005488 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;BBSome#GO:0034464;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG64757|UniProtKB=T1FXY6 T1FXY6 20213684 PTHR23101:SF25 RAB GDP/GTP EXCHANGE FACTOR GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme binding#GO:0019899 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;cytosol#GO:0005829;intracellular vesicle#GO:0097708;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG66730|UniProtKB=T1FYP8 T1FYP8 20213946 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;metal ion transport#GO:0030001;homeostatic process#GO:0042592 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG156059|UniProtKB=T1ELR2 T1ELR2 20197512 PTHR11938:SF151 FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid biosynthetic process#GO:0006694;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FdxR#P04604 HELRO|EnsemblGenome=HelroG101782|UniProtKB=T1ED70 T1ED70 20194522 PTHR31058:SF2 ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN multicellular organism development#GO:0007275;positive regulation of cell differentiation#GO:0045597;positive regulation of transcription by RNA polymerase II#GO:0045944;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of neuron differentiation#GO:0045664;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168855|UniProtKB=T1F117 T1F117 20202517 PTHR11306:SF0 NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED LP08842P-RELATED steroid binding#GO:0005496;lipid binding#GO:0008289;sterol binding#GO:0032934;binding#GO:0005488 macromolecule localization#GO:0033036;lipid transport#GO:0006869;transport#GO:0006810;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;establishment of localization#GO:0051234;sterol transport#GO:0015918 HELRO|EnsemblGenome=HelroG142806|UniProtKB=T1EJ77 T1EJ77 20196627 PTHR47978:SF40 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33 nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG76346|UniProtKB=T1G2I6 T1G2I6 20215284 PTHR23349:SF112 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST 48 RELATED 1, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG174783|UniProtKB=T1F8G9 T1F8G9 20205118 PTHR19282:SF507 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185922|UniProtKB=T1FNG0 T1FNG0 20210357 PTHR24073:SF471 DRAB5-RELATED RAS-RELATED PROTEIN RAB-24 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;autophagosome#GO:0005776;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG164927|UniProtKB=T1EVZ3 T1EVZ3 20200743 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG190950|UniProtKB=T1FSG3 T1FSG3 20211760 PTHR15913:SF0 ACID CLUSTER PROTEIN 33 MASPARDIN HELRO|EnsemblGenome=HelroG170286|UniProtKB=T1F2V8 T1F2V8 20203157 PTHR48033:SF9 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN TAR DNA-BINDING PROTEIN 43 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192356|UniProtKB=T1FTU9 T1FTU9 20212246 PTHR13167:SF48 PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 detection of mechanical stimulus#GO:0050982;response to external stimulus#GO:0009605;regulation of biological quality#GO:0065008;regulation of membrane potential#GO:0042391;cellular response to abiotic stimulus#GO:0071214;response to mechanical stimulus#GO:0009612;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;detection of stimulus#GO:0051606;response to abiotic stimulus#GO:0009628;biological regulation#GO:0065007;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG171815|UniProtKB=T1F4Q6 T1F4Q6 20203805 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;snRNA metabolic process#GO:0016073;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nuclear mRNA surveillance#GO:0071028;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;tRNA metabolic process#GO:0006399 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG164796|UniProtKB=T1EVT5 T1EVT5 20200685 PTHR13402:SF6 RGPR-RELATED SECRETORY 16, ISOFORM I vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;ER to Golgi transport vesicle membrane#GO:0012507;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HELRO|EnsemblGenome=HelroG89477|UniProtKB=T1G7D2 T1G7D2 20216979 PTHR11380:SF17 TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13 DNA-templated transcription#GO:0006351;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transferase complex#GO:1990234;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG86808|UniProtKB=T1G6H1 T1G6H1 20216668 PTHR45691:SF6 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG178316|UniProtKB=T1FD26 T1FD26 20206725 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116136|UniProtKB=T1EGD2 T1EGD2 20195634 PTHR12346:SF71 SIN3B-RELATED PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;chromosome#GO:0005694;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>Sin3A#P00771 HELRO|EnsemblGenome=HelroG165356|UniProtKB=T1EWM7 T1EWM7 20200977 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG107242|UniProtKB=T1EE90 T1EE90 20194892 PTHR46395:SF1 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1 GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 regulation of localization#GO:0032879;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of transport#GO:0051049;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of endocytosis#GO:0030100;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 GTPase-activating protein#PC00257;G-protein modulator#PC00022 Integrin signalling pathway#P00034>ASAP1#P00909 HELRO|EnsemblGenome=HelroG188524|UniProtKB=T1FQ32 T1FQ32 20210929 PTHR48105:SF21 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN REDUCTASE 2, MITOCHONDRIAL oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454;cellular homeostasis#GO:0019725 mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG146726|UniProtKB=T1EJU0 T1EJU0 20196840 PTHR23147:SF189 SERINE/ARGININE RICH SPLICING FACTOR SERINE AND ARGININE-RICH-SPLICING FACTOR 3A-RELATED organelle lumen#GO:0043233;nuclear speck#GO:0016607;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG75061|UniProtKB=T1G201 T1G201 20215099 PTHR11993:SF48 NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;electron transfer activity#GO:0009055;oxidoreductase activity, acting on NAD(P)H#GO:0016651;monoatomic cation transmembrane transporter activity#GO:0008324;NADH dehydrogenase activity#GO:0003954 aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;organelle membrane#GO:0031090;transporter complex#GO:1990351 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181123|UniProtKB=T1FGM9 T1FGM9 20207978 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170875|UniProtKB=T1F3J3 T1F3J3 20203392 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HELRO|EnsemblGenome=HelroG73386|UniProtKB=T1G1D3 T1G1D3 20214881 PTHR22677:SF4 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60 REPEAT PROTEIN, PUTATIVE-RELATED HELRO|EnsemblGenome=HelroG169963|UniProtKB=T1F2H6 T1F2H6 20203026 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165255|UniProtKB=T1EWI2 T1EWI2 20200932 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192551|UniProtKB=T1FU25 T1FU25 20212321 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG68430|UniProtKB=T1FZE6 T1FZE6 20214194 PTHR10177:SF527 CYCLINS CYCLIN D, ISOFORM D kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;mitotic cell cycle phase transition#GO:0044772;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cell cycle G1/S phase transition#GO:0044843;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;positive regulation of cell cycle#GO:0045787;positive regulation of cell cycle G1/S phase transition#GO:1902808;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047;positive regulation of mitotic cell cycle#GO:0045931 membraneless organelle#GO:0043228;protein kinase complex#GO:1902911;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 kinase activator#PC00138 Cell cycle#P00013>Cyclin D#P00484;Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG183685|UniProtKB=T1FK12 T1FK12 20209161 PTHR23050:SF325 CALCIUM BINDING PROTEIN CENTRIN-3 calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;microtubule binding#GO:0008017;cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG156393|UniProtKB=T1ELV3 T1ELV3 20197553 PTHR11879:SF58 ASPARTATE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transferase#PC00220;transaminase#PC00216;metabolite interconversion enzyme#PC00262 Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HELRO|EnsemblGenome=HelroG170561|UniProtKB=T1F367 T1F367 20203266 PTHR21346:SF0 FUN14 DOMAIN CONTAINING RE45833P metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;autophagy#GO:0006914;cellular process#GO:0009987;catabolic process#GO:0009056;process utilizing autophagic mechanism#GO:0061919 organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HELRO|EnsemblGenome=HelroG181419|UniProtKB=T1FGZ6 T1FGZ6 20208095 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG108236|UniProtKB=T1EEH5 T1EEH5 20194977 PTHR10741:SF2 TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X TRANSLIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG180928|UniProtKB=T1FGF6 T1FGF6 20207905 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG134261|UniProtKB=T1EI37 T1EI37 20196237 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG86839|UniProtKB=T1G6H9 T1G6H9 20216676 PTHR12119:SF2 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C CYTOCHROME B-C1 COMPLEX SUBUNIT 8 respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773 catalytic complex#GO:1902494;respiratory chain complex III#GO:0045275;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG153989|UniProtKB=T1ELD5 T1ELD5 20197385 PTHR43226:SF1 XAA-PRO AMINOPEPTIDASE 3 XAA-PRO DIPEPTIDASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG190302|UniProtKB=T1FRV8 T1FRV8 20211555 PTHR12675:SF12 MUSCLEBLIND-LIKE PROTEIN PROTEIN MUSCLEBLIND RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185611|UniProtKB=T1FN13 T1FN13 20210212 PTHR13116:SF5 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3 membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;EMC complex#GO:0072546;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG93606|UniProtKB=T1G8W8 T1G8W8 20217515 PTHR24356:SF450 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE TRICORNERED transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;establishment or maintenance of cell polarity#GO:0007163;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG114997|UniProtKB=T1EG57 T1EG57 20195559 PTHR11237:SF6 COENZYME Q10 BIOSYNTHESIS PROTEIN 7 NADPH-DEPENDENT 3-DEMETHOXYUBIQUINONE 3-HYDROXYLASE, MITOCHONDRIAL oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 small molecule biosynthetic process#GO:0044283;regulation of reactive oxygen species metabolic process#GO:2000377;metabolic process#GO:0008152;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744;regulation of biological process#GO:0050789;ketone metabolic process#GO:0042180;regulation of metabolic process#GO:0019222;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;small molecule metabolic process#GO:0044281 organelle membrane#GO:0031090;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;nucleus#GO:0005634;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG175669|UniProtKB=T1F9I0 T1F9I0 20205479 PTHR15079:SF3 MYD88 MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;response to bacterium#GO:0009617;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;toll-like receptor 4 signaling pathway#GO:0034142;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;defense response to bacterium#GO:0042742;immune system process#GO:0002376;regulation of biological process#GO:0050789;defense response to Gram-positive bacterium#GO:0050830;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>MyD88#P01377;Toll pathway-drosophila#P06217>MyD88#P06346 HELRO|EnsemblGenome=HelroG192983|UniProtKB=T1FUH5 T1FUH5 20212471 PTHR12661:SF5 PETER PAN-RELATED SUPPRESSOR OF SWI4 1 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;rRNA binding#GO:0019843;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;preribosome, large subunit precursor#GO:0030687;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188910|UniProtKB=T1FQG9 T1FQG9 20211066 PTHR11841:SF3 REELIN EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG168375|UniProtKB=T1F0I2 T1F0I2 20202332 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160645|UniProtKB=T1EQJ8 T1EQJ8 20198848 PTHR22255:SF11 LP06548P G PROTEIN HELRO|EnsemblGenome=HelroG166177|UniProtKB=T1EXV5 T1EXV5 20201405 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70505|UniProtKB=T1G073 T1G073 20214471 PTHR10779:SF31 DYNEIN LIGHT CHAIN ROADBLOCK DYNEIN LIGHT CHAIN ROADBLOCK-TYPE 2 binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;dynein complex#GO:0030286;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG180247|UniProtKB=T1FFM5 T1FFM5 20207624 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100598|UniProtKB=T1ED07 T1ED07 20194459 PTHR21290:SF69 SPHINGOMYELIN SYNTHETASE SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772 ceramide metabolic process#GO:0006672;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HELRO|EnsemblGenome=HelroG105393|UniProtKB=T1EDU4 T1EDU4 20194746 PTHR21713:SF4 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED GH09281P-RELATED localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;protein targeting#GO:0006605;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG156036|UniProtKB=T1ELQ9 T1ELQ9 20197509 PTHR48015:SF21 SERINE/THREONINE-PROTEIN KINASE TAO NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG161475|UniProtKB=T1ERI3 T1ERI3 20199183 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72589|UniProtKB=T1G122 T1G122 20214770 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG75410|UniProtKB=T1G248 T1G248 20215146 PTHR12764:SF4 WD REPEAT DOMAIN-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG cell projection organization#GO:0030030;intraciliary retrograde transport#GO:0035721;protein localization to organelle#GO:0033365;microtubule-based movement#GO:0007018;protein localization to cilium#GO:0061512;intraciliary transport#GO:0042073;cellular component organization#GO:0016043;cilium assembly#GO:0060271;non-motile cilium assembly#GO:1905515;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810 non-motile cilium#GO:0097730;intraciliary transport particle A#GO:0030991;membrane-bounded organelle#GO:0043227;intraciliary transport particle#GO:0030990;cilium#GO:0005929;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG162250|UniProtKB=T1ESE9 T1ESE9 20199499 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168159|UniProtKB=T1F088 T1F088 20202238 PTHR13578:SF20 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB GROUP PROTEIN ASX binding#GO:0005488;chromatin binding#GO:0003682 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;PcG protein complex#GO:0031519;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG75833|UniProtKB=T1G2A9 T1G2A9 20215207 PTHR45134:SF5 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180632|UniProtKB=T1FG38 T1FG38 20207787 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993 HELRO|EnsemblGenome=HelroG160141|UniProtKB=T1EPV5 T1EPV5 20198605 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63728|UniProtKB=T1FXJ3 T1FXJ3 20213541 PTHR23355:SF68 RIBONUCLEASE DIS3-LIKE EXONUCLEASE 2 3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG193935|UniProtKB=T1FVH5 T1FVH5 20212821 PTHR12920:SF4 RYBP AND YAF2-RELATED GEO03726P1 DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG116381|UniProtKB=T1EGE4 T1EGE4 20195646 PTHR15822:SF4 TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN 5'-TYROSYL-DNA PHOSPHODIESTERASE binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;hydrolase activity#GO:0016787;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG171191|UniProtKB=T1F3X1 T1F3X1 20203520 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG64810|UniProtKB=T1FXZ7 T1FXZ7 20213695 PTHR23252:SF43 INTIMAL THICKNESS RECEPTOR-RELATED GPR180_TMEM145 TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181788|UniProtKB=T1FHB8 T1FHB8 20208217 PTHR34491:SF156 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED AUGMIN COMPLEX SUBUNIT DGT5 HELRO|EnsemblGenome=HelroG83313|UniProtKB=T1G540 T1G540 20216188 PTHR15241:SF386 TRANSFORMER-2-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN-RELATED RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG194726|UniProtKB=T1FWC6 T1FWC6 20213121 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG175779|UniProtKB=T1F9N2 T1F9N2 20205531 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG64112|UniProtKB=T1FXP5 T1FXP5 20213593 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;metal ion transport#GO:0030001;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG108533|UniProtKB=T1EEJ9 T1EEJ9 20195001 PTHR42721:SF42 SUGAR HYDROLASE-RELATED BETA-D-XYLOSIDASE 6-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 macromolecule metabolic process#GO:0043170;carbohydrate catabolic process#GO:0016052;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976;carbohydrate metabolic process#GO:0005975;xylan metabolic process#GO:0045491;primary metabolic process#GO:0044238;polysaccharide catabolic process#GO:0000272;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;hydrolase#PC00121;glucosidase#PC00108 HELRO|EnsemblGenome=HelroG69451|UniProtKB=T1FZV5 T1FZV5 20214353 PTHR19308:SF8 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG168674|UniProtKB=T1F0U7 T1F0U7 20202447 PTHR43157:SF74 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED DEHYDROGENASES, SHORT CHAIN-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG162221|UniProtKB=T1ESD4 T1ESD4 20199484 PTHR10218:SF365 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA Q SUBUNIT-RELATED molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;G protein-coupled dopamine receptor signaling pathway#GO:0007212;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;biological regulation#GO:0065007;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 heterotrimeric G-protein#PC00117;G-protein#PC00020 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Endothelin signaling pathway#P00019>Gq#P00586;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Wnt signaling pathway#P00057>Galpha#P01451;PI3 kinase pathway#P00048>Galpha#P01199;Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057 HELRO|EnsemblGenome=HelroG182367|UniProtKB=T1FI40 T1FI40 20208489 PTHR37862:SF2 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 UBZ2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172026|UniProtKB=T1F4Y5 T1F4Y5 20203884 PTHR13703:SF54 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;molecular function regulator activity#GO:0098772;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>RSmads#P01292 HELRO|EnsemblGenome=HelroG179158|UniProtKB=T1FEA1 T1FEA1 20207150 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG79038|UniProtKB=T1G3J0 T1G3J0 20215638 PTHR14586:SF1 THIAMINE-TRIPHOSPHATASE THIAMINE-TRIPHOSPHATASE pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;cation binding#GO:0043169;magnesium ion binding#GO:0000287;ion binding#GO:0043167;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;small molecule binding#GO:0036094 cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;phosphorus metabolic process#GO:0006793;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 Thiamin metabolism#P02780>Thiamine triphosphatase#P03184 HELRO|EnsemblGenome=HelroG80453|UniProtKB=T1G409 T1G409 20215807 PTHR47977:SF64 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-30 nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi cisterna#GO:0031985;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG182684|UniProtKB=T1FIK9 T1FIK9 20208658 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG142747|UniProtKB=T1EJ72 T1EJ72 20196622 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG170437|UniProtKB=T1F324 T1F324 20203223 PTHR22526:SF2 ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED regulation of chromosome separation#GO:1905818;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of nuclear division#GO:0051783;regulation of cell cycle process#GO:0010564;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;regulation of chromosome organization#GO:0033044;regulation of response to stimulus#GO:0048583;regulation of chromosome segregation#GO:0051983;regulation of cellular process#GO:0050794;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular component organization#GO:0051128;regulation of sister chromatid segregation#GO:0033045;regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726;regulation of cell cycle phase transition#GO:1901987;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151 HELRO|EnsemblGenome=HelroG189453|UniProtKB=T1FR27 T1FR27 20211274 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG169961|UniProtKB=T1F2H4 T1F2H4 20203024 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81738|UniProtKB=T1G4I2 T1G4I2 20215980 PTHR43757:SF2 AMINOMETHYLTRANSFERASE AMINOMETHYLTRANSFERASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185204|UniProtKB=T1FMI2 T1FMI2 20210031 PTHR12304:SF4 INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE URIDINE NUCLEOSIDASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;purine-containing compound catabolic process#GO:0072523;purine nucleoside catabolic process#GO:0006152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;purine-containing compound metabolic process#GO:0072521;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;purine nucleoside metabolic process#GO:0042278;nucleoside catabolic process#GO:0009164 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194688|UniProtKB=T1FWB6 T1FWB6 20213112 PTHR22957:SF704 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG63878|UniProtKB=T1FXL7 T1FXL7 20213565 PTHR12465:SF0 UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG86102|UniProtKB=T1G673 T1G673 20216570 PTHR10739:SF13 CYTIDYLYLTRANSFERASE CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;phospholipid binding#GO:0005543;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylcholine binding#GO:0031210;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;cation binding#GO:0043169 transferase#PC00220 HELRO|EnsemblGenome=HelroG85704|UniProtKB=T1G620 T1G620 20216517 PTHR24045:SF0 FAMILY NOT NAMED FI02838P biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG190154|UniProtKB=T1FRR0 T1FRR0 20211507 PTHR15431:SF19 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTROSOMAL PROTEIN 20 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG110832|UniProtKB=T1EF55 T1EF55 20195207 PTHR13856:SF137 VHS DOMAIN CONTAINING PROTEIN FAMILY GH05942P protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG173681|UniProtKB=T1F741 T1F741 20204640 PTHR10281:SF120 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED NEUDESIN receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG69616|UniProtKB=T1FZX2 T1FZX2 20214370 PTHR24345:SF99 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047 condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;chromosome#GO:0005694;spindle pole#GO:0000922;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG162533|UniProtKB=T1EST2 T1EST2 20199632 PTHR16095:SF11 TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER TRANSMEMBRANE PROTEIN 143 HELRO|EnsemblGenome=HelroG170382|UniProtKB=T1F2Z3 T1F2Z3 20203192 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG145685|UniProtKB=T1EJM0 T1EJM0 20196770 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG108202|UniProtKB=T1EEG8 T1EEG8 20194970 PTHR21347:SF0 CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED LIPID SCRAMBLASE CLPTM1L cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG115589|UniProtKB=T1EG95 T1EG95 20195597 PTHR15075:SF2 ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG185659|UniProtKB=T1FN36 T1FN36 20210234 PTHR11205:SF18 RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN US7 structural molecule activity#GO:0005198;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;structural constituent of ribosome#GO:0003735;mRNA binding#GO:0003729 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177333|UniProtKB=T1FBI6 T1FBI6 20206185 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of neurogenesis#GO:0050767;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG158303|UniProtKB=T1EMM1 T1EMM1 20197821 PTHR46114:SF2 APPLE DOMAIN-CONTAINING PROTEIN SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG127771|UniProtKB=T1EHH7 T1EHH7 20196027 PTHR11193:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN E SMALL NUCLEAR RIBONUCLEOPROTEIN E cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;spliceosomal snRNP assembly#GO:0000387;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070 U4 snRNP#GO:0005687;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;U2 snRNP#GO:0005686 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG68435|UniProtKB=T1FZE7 T1FZE7 20214195 PTHR18952:SF283 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XB-RELATED metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG63257|UniProtKB=T1FXD0 T1FXD0 20213478 PTHR15315:SF112 RING FINGER PROTEIN 41, 151 PDZ DOMAIN CONTAINING RING FINGER 3 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 HELRO|EnsemblGenome=HelroG65441|UniProtKB=T1FY78 T1FY78 20213776 PTHR19134:SF449 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66570|UniProtKB=T1FYM7 T1FYM7 20213925 PTHR11081:SF81 FLAP ENDONUCLEASE FAMILY MEMBER FLAP ENDONUCLEASE 1 endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;hydrolase activity#GO:0016787;magnesium ion binding#GO:0000287;cation binding#GO:0043169;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;catalytic activity, acting on DNA#GO:0140097;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;metal ion binding#GO:0046872;DNA endonuclease activity#GO:0004520;5'-3' exonuclease activity#GO:0008409;nuclease activity#GO:0004518;binding#GO:0005488;exonuclease activity#GO:0004527 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;DNA replication#GO:0006260;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 exodeoxyribonuclease#PC00098;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG165241|UniProtKB=T1EWH5 T1EWH5 20200925 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG173013|UniProtKB=T1F696 T1F696 20204345 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG107834|UniProtKB=T1EED2 T1EED2 20194934 PTHR45736:SF1 ZINC FINGER MYM-TYPE PROTEIN WITHOUT CHILDREN, ISOFORM B zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG174017|UniProtKB=T1F7H4 T1F7H4 20204773 PTHR11618:SF85 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB transcription factor binding#GO:0008134;binding#GO:0005488;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;organelle#GO:0043226 general transcription factor#PC00259 General transcription regulation#P00023>TFIIB#P00668;Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397 HELRO|EnsemblGenome=HelroG185239|UniProtKB=T1FMJ7 T1FMJ7 20210046 PTHR18860:SF184 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA scaffold/adaptor protein#PC00226 PI3 kinase pathway#P00048>14-3-3#P01206;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624;Parkinson disease#P00049>14-3-3#P01238 HELRO|EnsemblGenome=HelroG175087|UniProtKB=T1F8U2 T1F8U2 20205241 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG192269|UniProtKB=T1FTS2 T1FTS2 20212219 PTHR13612:SF0 ENHANCER OF MRNA-DECAPPING PROTEIN 3 ENHANCER OF MRNA-DECAPPING PROTEIN 3 nucleic acid binding#GO:0003676;binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;molecular condensate scaffold activity#GO:0140693;RNA binding#GO:0003723 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;P-body assembly#GO:0033962;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA decapping#GO:0110154;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG170462|UniProtKB=T1F334 T1F334 20203233 PTHR13328:SF7 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023 HELRO|EnsemblGenome=HelroG165875|UniProtKB=T1EXE0 T1EXE0 20201240 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG64460|UniProtKB=T1FXV4 T1FXV4 20213652 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;zinc ion binding#GO:0008270;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169805|UniProtKB=T1F2C3 T1F2C3 20202973 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG94890|UniProtKB=T1G937 T1G937 20217584 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG131179|UniProtKB=T1EHV5 T1EHV5 20196155 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG172083|UniProtKB=T1F505 T1F505 20203904 PTHR15673:SF2 IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1 IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG108105|UniProtKB=T1EEF5 T1EEF5 20194957 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG110355|UniProtKB=T1EF17 T1EF17 20195169 PTHR12552:SF1 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN GRAF molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG83262|UniProtKB=T1G529 T1G529 20216177 PTHR11062:SF73 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-LIKE 3 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG185666|UniProtKB=T1FN42 T1FN42 20210240 PTHR20883:SF15 PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1 PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG117313|UniProtKB=T1EGM0 T1EGM0 20195720 PTHR10722:SF0 60S RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN EL19 RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG116895|UniProtKB=T1EGI4 T1EGI4 20195686 PTHR12640:SF0 RIBOPHORIN II DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160843|UniProtKB=T1EQT3 T1EQT3 20198933 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;ion binding#GO:0043167;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG127558|UniProtKB=T1EHF4 T1EHF4 20196004 PTHR15710:SF214 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG72557|UniProtKB=T1G117 T1G117 20214765 PTHR12176:SF86 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN EEF1A LYSINE METHYLTRANSFERASE 4 protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG121284|UniProtKB=T1EGR3 T1EGR3 20195763 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490;DNA binding#GO:0003677;histone acetyltransferase activity#GO:0004402;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;chromatin binding#GO:0003682;protein N-acetyltransferase activity#GO:0034212;transcription coactivator activity#GO:0003713;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;binding#GO:0005488;acetyltransferase activity#GO:0016407;transcription regulator activity#GO:0140110 positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355 chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;DPP-SCW signaling pathway#P06212>NEJ#P06260;p53 pathway#P00059>CBP#P04623;Huntington disease#P00029>CBP#P00777;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;DPP signaling pathway#P06213>NEJ#P06284;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295 HELRO|EnsemblGenome=HelroG62766|UniProtKB=T1FX49 T1FX49 20213397 PTHR31457:SF2 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE catalytic activity#GO:0003824;oxidoreductase activity, acting on metal ions#GO:0016722;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;heterocyclic compound binding#GO:1901363;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 cellular process#GO:0009987;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG69384|UniProtKB=T1FZU3 T1FZU3 20214341 PTHR12294:SF1 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;homeostatic process#GO:0042592;metal ion transport#GO:0030001;mitochondrial calcium ion homeostasis#GO:0051560;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;calcium channel complex#GO:0034704;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle membrane#GO:0031090;transporter complex#GO:1990351;cation channel complex#GO:0034703;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG144288|UniProtKB=T1EJE1 T1EJE1 20196691 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG developmental process#GO:0032502;spermatogenesis#GO:0007283;plasma membrane bounded cell projection assembly#GO:0120031;cellular developmental process#GO:0048869;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;spermatid differentiation#GO:0048515;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG79313|UniProtKB=T1G3M5 T1G3M5 20215673 PTHR21257:SF57 DELTA(14)-STEROL REDUCTASE 7-DEHYDROCHOLESTEROL REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;primary metabolic process#GO:0044238;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG114428|UniProtKB=T1EG16 T1EG16 20195518 PTHR11085:SF6 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;NAD-dependent protein lysine deacetylase activity#GO:0034979;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;nucleolus organization#GO:0007000;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;nucleus organization#GO:0006997;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG172966|UniProtKB=T1F682 T1F682 20204331 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191935|UniProtKB=T1FTF2 T1FTF2 20212099 PTHR15576:SF1 RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1 RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1 UDP-glycosyltransferase activity#GO:0008194;xylosyltransferase activity#GO:0042285;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;UDP-xylosyltransferase activity#GO:0035252;pentosyltransferase activity#GO:0016763 metabolic process#GO:0008152;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158457|UniProtKB=T1EMT4 T1EMT4 20197884 PTHR47972:SF28 KINESIN-LIKE PROTEIN KLP-3 KINESIN-LIKE PROTEIN KLP-3 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG168226|UniProtKB=T1F0C0 T1F0C0 20202270 PTHR24115:SF1025 KINESIN-RELATED KINESIN HEAVY CHAIN macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574 establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;localization#GO:0051179;cellular localization#GO:0051641;anterograde axonal transport#GO:0008089;axonal transport#GO:0098930;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;synaptic vesicle localization#GO:0097479;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;axo-dendritic transport#GO:0008088;synaptic vesicle transport#GO:0048489;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular process#GO:0009987;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;vesicle cytoskeletal trafficking#GO:0099518;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;transport#GO:0006810 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188469|UniProtKB=T1FQ10 T1FQ10 20210907 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG176599|UniProtKB=T1FAP7 T1FAP7 20205896 PTHR33865:SF3 PROTEIN FAM183B CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 144 ciliary base#GO:0097546;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG88718|UniProtKB=T1G757 T1G757 20216904 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cell fate commitment#GO:0045165;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;cell fate specification#GO:0001708;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;neuron fate commitment#GO:0048663;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105497|UniProtKB=T1EDV8 T1EDV8 20194760 PTHR19443:SF16 HEXOKINASE HEXOKINASE-2-RELATED hexokinase activity#GO:0004396;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740 glucose metabolic process#GO:0006006;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 Glycolysis#P00024>Hexokinase#P00677;Pentose phosphate pathway#P02762>Hexokinase#P03079;Fructose galactose metabolism#P02744>Hexokinase#P02966 HELRO|EnsemblGenome=HelroG66984|UniProtKB=T1FYU7 T1FYU7 20213995 PTHR43195:SF1 TRANSKETOLASE TRANSKETOLASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transketolase or transaldolase activity#GO:0016744;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;transketolase activity#GO:0004802;cation binding#GO:0043169 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transketolase#PC00221;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177065|UniProtKB=T1FB69 T1FB69 20206068 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG189209|UniProtKB=T1FQS7 T1FQS7 20211174 PTHR15668:SF5 JM1 PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 22 binding#GO:0005488;protein binding#GO:0005515 endocytic recycling#GO:0032456;regulation of biological process#GO:0050789;cellular localization#GO:0051641;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;vesicle-mediated transport#GO:0016192;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;regulation of protein metabolic process#GO:0051246;endosomal transport#GO:0016197;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;localization#GO:0051179;localization within membrane#GO:0051668;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;vesicle-mediated transport to the plasma membrane#GO:0098876;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;transport#GO:0006810;regulation of response to stimulus#GO:0048583;intracellular transport#GO:0046907 HELRO|EnsemblGenome=HelroG77825|UniProtKB=T1G346 T1G346 20215494 PTHR46472:SF1 NUCLEOREDOXIN NUCLEOREDOXIN protein-disulfide reductase activity#GO:0015035;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036;antioxidant activity#GO:0016209;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of protein ubiquitination#GO:0031396;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of protein modification process#GO:0031399;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;negative regulation of metabolic process#GO:0009892;regulation of Wnt signaling pathway#GO:0030111;negative regulation of protein metabolic process#GO:0051248;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of protein ubiquitination#GO:0031397;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of post-translational protein modification#GO:1901873 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG113396|UniProtKB=T1EFS2 T1EFS2 20195424 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG85598|UniProtKB=T1G604 T1G604 20216501 PTHR45832:SF24 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110480|UniProtKB=T1EF26 T1EF26 20195178 PTHR43908:SF3 AT29763P-RELATED AT29763P-RELATED protein binding#GO:0005515;Hsp70 protein binding#GO:0030544;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;heat shock protein binding#GO:0031072 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;cellular response to misfolded protein#GO:0071218;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;response to misfolded protein#GO:0051788;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166215|UniProtKB=T1EXW9 T1EXW9 20201419 PTHR23354:SF132 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED OXIDATION RESISTANCE PROTEIN 1 response to stress#GO:0006950;response to oxidative stress#GO:0006979;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG90681|UniProtKB=T1G7U3 T1G7U3 20217140 PTHR13554:SF10 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5 protease#PC00190 HELRO|EnsemblGenome=HelroG125362|UniProtKB=T1EH55 T1EH55 20195905 PTHR24155:SF11 OSTEOCLAST-STIMULATING FACTOR 1 CASKIN, ISOFORM B signaling adaptor activity#GO:0035591;protein binding#GO:0005515;phosphatase binding#GO:0019902;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;enzyme binding#GO:0019899;protein phosphatase binding#GO:0019903;molecular adaptor activity#GO:0060090 neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731 axon#GO:0030424;anchoring junction#GO:0070161;cell junction#GO:0030054;neuron projection#GO:0043005;cell projection#GO:0042995;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG111311|UniProtKB=T1EFA2 T1EFA2 20195254 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 19-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192726|UniProtKB=T1FU84 T1FU84 20212380 PTHR18884:SF137 SEPTIN SEPTIN-7 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cytokinesis#GO:0000910;localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cell cycle#GO:0007049;cell cycle process#GO:0022402;cell division#GO:0051301;cellular process#GO:0009987 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG195047|UniProtKB=T1FWP8 T1FWP8 20213243 PTHR14963:SF7 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 19 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG170732|UniProtKB=T1F3D2 T1F3D2 20203331 PTHR15911:SF6 WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase binding#GO:0070063;chromatin binding#GO:0003682;enzyme binding#GO:0019899;binding#GO:0005488 positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of TOR signaling#GO:0032006;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;regulation of autophagy#GO:0010506;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156422|UniProtKB=T1ELW1 T1ELW1 20197561 PTHR25462:SF285 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG169282|UniProtKB=T1F1Q1 T1F1Q1 20202751 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG194441|UniProtKB=T1FW21 T1FW21 20213017 PTHR11588:SF462 TUBULIN TUBULIN ALPHA CHAIN purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 microtubule-based process#GO:0007017;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;developmental process#GO:0032502;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;cellular process#GO:0009987;organelle organization#GO:0006996;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;mitotic cell cycle#GO:0000278;cell differentiation#GO:0030154;cellular component organization#GO:0016043;cell cycle#GO:0007049 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 cytoskeletal protein#PC00085;tubulin#PC00228 HELRO|EnsemblGenome=HelroG179340|UniProtKB=T1FEK6 T1FEK6 20207255 PTHR24211:SF20 LIM DOMAIN-CONTAINING PROTEIN PROTEIN ESPINAS-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG136896|UniProtKB=T1EIG4 T1EIG4 20196364 PTHR22593:SF2 TRANSMEMBRANE PROTEIN 18 TRANSMEMBRANE PROTEIN 18 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;nucleus#GO:0005634;nuclear membrane#GO:0031965;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG143063|UniProtKB=T1EJ89 T1EJ89 20196639 PTHR28624:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 51 MITOCHONDRIAL POTASSIUM CHANNEL HELRO|EnsemblGenome=HelroG180805|UniProtKB=T1FGA9 T1FGA9 20207858 PTHR14312:SF5 CREB/ATF BZIP TRANSCRIPTION FACTOR IPT_TIG DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG183145|UniProtKB=T1FJ73 T1FJ73 20208872 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163905|UniProtKB=T1EUL6 T1EUL6 20200266 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG108802|UniProtKB=T1EEM6 T1EEM6 20195028 PTHR12674:SF2 PREFOLDIN SUBUNIT 5 PREFOLDIN SUBUNIT 5 cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG75597|UniProtKB=T1G270 T1G270 20215168 PTHR45712:SF37 AGAP008170-PA LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE HELRO|EnsemblGenome=HelroG103911|UniProtKB=T1EDI3 T1EDI3 20194635 PTHR23003:SF51 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE-ARGININE PROTEIN 55 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG175148|UniProtKB=T1F8X2 T1F8X2 20205271 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122556|UniProtKB=T1EGV1 T1EGV1 20195801 PTHR19300:SF65 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG157853|UniProtKB=T1EMG8 T1EMG8 20197768 PTHR11006:SF124 PROTEIN ARGININE N-METHYLTRANSFERASE ARGININE METHYLTRANSFERASE 9-RELATED catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;histone modifying activity#GO:0140993;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157973|UniProtKB=T1EMI4 T1EMI4 20197784 PTHR14068:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 eukaryotic translation initiation factor 3 complex#GO:0005852;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG108230|UniProtKB=T1EEH3 T1EEH3 20194975 PTHR44027:SF8 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804 synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;distal axon#GO:0150034;neuron projection terminus#GO:0044306;cell projection#GO:0042995;presynapse#GO:0098793;neuron projection#GO:0043005;cell junction#GO:0030054;axon terminus#GO:0043679;axon#GO:0030424 chaperone#PC00072 HELRO|EnsemblGenome=HelroG98434|UniProtKB=T1G9M7 T1G9M7 20217773 PTHR45755:SF1 FAMILY NOT NAMED PROTON-COUPLED ZINC ANTIPORTER SLC30A5 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 zinc ion transmembrane transport#GO:0071577;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;transport#GO:0006810;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;Golgi stack#GO:0005795;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 HELRO|EnsemblGenome=HelroG191755|UniProtKB=T1FT99 T1FT99 20212046 PTHR45803:SF5 SOX100B SOX100B double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG170711|UniProtKB=T1F3C3 T1F3C3 20203322 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155617|UniProtKB=T1ELJ8 T1ELJ8 20197448 PTHR23138:SF141 RAN BINDING PROTEIN NUCLEAR PORE COMPLEX PROTEIN NUP50 establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG90827|UniProtKB=T1G7W7 T1G7W7 20217164 PTHR24068:SF33 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG68699|UniProtKB=T1FZI5 T1FZI5 20214233 PTHR24115:SF789 KINESIN-RELATED KINESIN-LIKE PROTEIN KLP68D catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;microtubule-based movement#GO:0007018;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;microtubule-based process#GO:0007017 organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG135638|UniProtKB=T1EI97 T1EI97 20196297 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to stress#GO:0033554;regulation of translational initiation#GO:0006446;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG114581|UniProtKB=T1EG33 T1EG33 20195535 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING IP01257P-RELATED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG89773|UniProtKB=T1G7H3 T1G7H3 20217020 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG165635|UniProtKB=T1EX38 T1EX38 20201138 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG183444|UniProtKB=T1FJN9 T1FJN9 20209038 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG163311|UniProtKB=T1ETW4 T1ETW4 20200014 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN LD44267P intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG174805|UniProtKB=T1F8I0 T1F8I0 20205129 PTHR12479:SF10 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of membrane permeability#GO:0090559 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773 transporter#PC00227 HELRO|EnsemblGenome=HelroG179619|UniProtKB=T1FEY1 T1FEY1 20207380 PTHR16151:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;intracellular organelle#GO:0043229;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG151058|UniProtKB=T1EKI5 T1EKI5 20197085 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN LD44267P cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163087|UniProtKB=T1ETN0 T1ETN0 20199930 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG86064|UniProtKB=T1G668 T1G668 20216565 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG161019|UniProtKB=T1ER06 T1ER06 20199006 PTHR44054:SF3 SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77422|UniProtKB=T1G2X4 T1G2X4 20215422 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG70858|UniProtKB=T1G0D1 T1G0D1 20214529 PTHR45810:SF18 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG180295|UniProtKB=T1FFP6 T1FFP6 20207645 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG184834|UniProtKB=T1FM23 T1FM23 20209872 PTHR16515:SF59 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 1 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG88795|UniProtKB=T1G766 T1G766 20216913 PTHR10293:SF16 GLUTAREDOXIN FAMILY MEMBER GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG64321|UniProtKB=T1FXS8 T1FXS8 20213626 PTHR10658:SF11 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN VIBRATOR, ISOFORM B transporter#PC00227 HELRO|EnsemblGenome=HelroG188085|UniProtKB=T1FPL9 T1FPL9 20210766 PTHR22957:SF352 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER WHACKED enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG186218|UniProtKB=T1FNT9 T1FNT9 20210486 PTHR43407:SF1 GLUTAMINE SYNTHETASE LENGSIN ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;homeostatic process#GO:0042592;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;response to nutrient levels#GO:0031667;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;chemical homeostasis#GO:0048878;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;proteinogenic amino acid biosynthetic process#GO:0170038 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483 HELRO|EnsemblGenome=HelroG83483|UniProtKB=T1G561 T1G561 20216209 PTHR23050:SF552 CALCIUM BINDING PROTEIN AT16150P-RELATED molecular function regulator activity#GO:0098772;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;T cell activation#P00053>Calmodulin#P01305;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG170102|UniProtKB=T1F2M6 T1F2M6 20203075 PTHR46644:SF4 DNA REPAIR PROTEIN XRCC2 DNA REPAIR PROTEIN XRCC2 four-way junction DNA binding#GO:0000400;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA recombination#GO:0006310;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139 centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;replication fork#GO:0005657;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG159966|UniProtKB=T1EPL8 T1EPL8 20198518 PTHR22811:SF218 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 7-LIKE molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG183667|UniProtKB=T1FK05 T1FK05 20209154 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG79008|UniProtKB=T1G3I3 T1G3I3 20215631 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186224|UniProtKB=T1FNU2 T1FNU2 20210489 PTHR24056:SF508 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 10 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;regulation of cell cycle#GO:0051726;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic cell cycle phase transition#GO:0044772;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle G2/M phase transition#GO:1902749;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73159|UniProtKB=T1G1B0 T1G1B0 20214858 PTHR23429:SF23 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE glucose-6-phosphate dehydrogenase activity#GO:0004345;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;pentose-phosphate shunt, oxidative branch#GO:0009051;generation of precursor metabolites and energy#GO:0006091;glucose metabolic process#GO:0006006;nucleobase-containing small molecule metabolic process#GO:0055086;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;hexose metabolic process#GO:0019318;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG170451|UniProtKB=T1F329 T1F329 20203228 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171705|UniProtKB=T1F4K6 T1F4K6 20203755 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192468|UniProtKB=T1FTZ7 T1FTZ7 20212294 PTHR15904:SF17 FAM13 RHO-GAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97702|UniProtKB=T1G9I6 T1G9I6 20217733 PTHR23147:SF245 SERINE/ARGININE RICH SPLICING FACTOR CCHC-TYPE DOMAIN-CONTAINING PROTEIN membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG186073|UniProtKB=T1FNM7 T1FNM7 20210424 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG95740|UniProtKB=T1G972 T1G972 20217619 PTHR10554:SF12 SYNTROPHIN IP02644P plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG69604|UniProtKB=T1FZX1 T1FZX1 20214369 PTHR45942:SF1 Calcineurin subunit B PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B, ALPHA enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208 calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;calcineurin-mediated signaling#GO:0097720;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG172935|UniProtKB=T1F659 T1F659 20204308 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175095|UniProtKB=T1F8U3 T1F8U3 20205242 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG158875|UniProtKB=T1ENC8 T1ENC8 20198078 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG161035|UniProtKB=T1ER14 T1ER14 20199014 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80591|UniProtKB=T1G423 T1G423 20215821 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG170324|UniProtKB=T1F2X4 T1F2X4 20203173 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114111|UniProtKB=T1EFZ1 T1EFZ1 20195493 PTHR19332:SF1 PEROXISOMAL MEMBRANE PROTEIN PEX13 PEROXISOMAL MEMBRANE PROTEIN PEX13 peroxisomal transport#GO:0043574;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;peroxisome organization#GO:0007031;protein import into peroxisome matrix#GO:0016558;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996 bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;transporter complex#GO:1990351;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG182320|UniProtKB=T1FI22 T1FI22 20208471 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152313|UniProtKB=T1EKQ8 T1EKQ8 20197158 PTHR21346:SF0 FUN14 DOMAIN CONTAINING RE45833P catabolic process#GO:0009056;process utilizing autophagic mechanism#GO:0061919;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;autophagy#GO:0006914;cellular process#GO:0009987 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG162820|UniProtKB=T1ET78 T1ET78 20199778 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194385|UniProtKB=T1FW01 T1FW01 20212997 PTHR11071:SF593 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 chaperone#PC00072 HELRO|EnsemblGenome=HelroG172109|UniProtKB=T1F514 T1F514 20203913 PTHR46961:SF11 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG85733|UniProtKB=T1G625 T1G625 20216522 PTHR21013:SF10 ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2 chaperone#PC00072 HELRO|EnsemblGenome=HelroG77074|UniProtKB=T1G2T0 T1G2T0 20215378 PTHR31233:SF6 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;microtubule anchoring at microtubule organizing center#GO:0072393;cellular component organization or biogenesis#GO:0071840;microtubule anchoring#GO:0034453;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;regulation of microtubule-based process#GO:0032886 cytosol#GO:0005829;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG176799|UniProtKB=T1FAX3 T1FAX3 20205972 PTHR22692:SF26 MYOSIN VII, XV SH3 DOMAIN-CONTAINING PROTEIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG63198|UniProtKB=T1FXC0 T1FXC0 20213468 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG82533|UniProtKB=T1G4T3 T1G4T3 20216081 PTHR12480:SF35 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD JMJC DOMAIN-CONTAINING PROTEIN 8 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191974|UniProtKB=T1FTH1 T1FTH1 20212118 PTHR24347:SF444 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG159811|UniProtKB=T1EPF2 T1EPF2 20198452 PTHR22914:SF42 CHITIN SYNTHASE CHITIN SYNTHASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 amino sugar metabolic process#GO:0006040;biosynthetic process#GO:0009058;aminoglycan biosynthetic process#GO:0006023;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;chitin metabolic process#GO:0006030 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG141392|UniProtKB=T1EJ34 T1EJ34 20196584 PTHR11662:SF456 SOLUTE CARRIER FAMILY 17 VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943 trans-synaptic signaling#GO:0099537;cellular localization#GO:0051641;regulation of synapse structure or activity#GO:0050803;localization#GO:0051179;cell communication#GO:0007154;regulation of biological quality#GO:0065008;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynapse#GO:0098793;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG184778|UniProtKB=T1FLZ1 T1FLZ1 20209840 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92407|UniProtKB=T1G8F7 T1G8F7 20217354 PTHR47573:SF1 PROTEIN AF-9 HOMOLOG PROTEIN AF-9 HOMOLOG HELRO|EnsemblGenome=HelroG186214|UniProtKB=T1FNT8 T1FNT8 20210485 PTHR14154:SF3 UPF0041 BRAIN PROTEIN 44-RELATED MITOCHONDRIAL PYRUVATE CARRIER monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;carboxylic acid transport#GO:0046942;transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;organic acid transport#GO:0015849;intracellular transport#GO:0046907;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular localization#GO:0051641 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG183216|UniProtKB=T1FJB7 T1FJB7 20208916 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170384|UniProtKB=T1F2Z5 T1F2Z5 20203194 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG88948|UniProtKB=T1G775 T1G775 20216922 PTHR24171:SF15 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50-RELATED HELRO|EnsemblGenome=HelroG160929|UniProtKB=T1EQV5 T1EQV5 20198955 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG162869|UniProtKB=T1ETA8 T1ETA8 20199808 PTHR45749:SF23 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1 ISOFORM X1 HELRO|EnsemblGenome=HelroG68671|UniProtKB=T1FZI0 T1FZI0 20214228 PTHR48526:SF2 SPLICING FACTOR 3B SUBUNIT 6 SPLICING FACTOR 3B SUBUNIT 6 HELRO|EnsemblGenome=HelroG90708|UniProtKB=T1G7U7 T1G7U7 20217144 PTHR12245:SF13 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN B30.2_SPRY DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG74808|UniProtKB=T1G1V9 T1G1V9 20215057 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;3'-5' exonuclease activity#GO:0008408;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;phosphoric ester hydrolase activity#GO:0042578;DNA exonuclease activity#GO:0004529;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;3'-5'-DNA exonuclease activity#GO:0008296;DNA endonuclease activity#GO:0004520;exonuclease activity#GO:0004527 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;base-excision repair#GO:0006284;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 HELRO|EnsemblGenome=HelroG192690|UniProtKB=T1FU72 T1FU72 20212368 PTHR13232:SF10 NAD(P)H-HYDRATE EPIMERASE NAD(P)H-HYDRATE EPIMERASE metabolite interconversion enzyme#PC00262;epimerase/racemase#PC00096 HELRO|EnsemblGenome=HelroG173319|UniProtKB=T1F6N9 T1F6N9 20204488 PTHR23261:SF77 GROUNDHOG-RELATED GROUND-LIKE DOMAIN-CONTAINING PROTEIN intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG85388|UniProtKB=T1G5W3 T1G5W3 20216460 PTHR11373:SF4 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE FALTEN, ISOFORM B catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;purine nucleotide catabolic process#GO:0006195;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;purine nucleoside triphosphate metabolic process#GO:0009144;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG186180|UniProtKB=T1FNS1 T1FNS1 20210468 PTHR47385:SF14 CALPONIN TRANSGELIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 HELRO|EnsemblGenome=HelroG175645|UniProtKB=T1F9G8 T1F9G8 20205467 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG84739|UniProtKB=T1G5M9 T1G5M9 20216376 PTHR15664:SF21 C20ORF30 PROTEIN TRANSMEMBRANE PROTEIN 230 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG88075|UniProtKB=T1G6Y2 T1G6Y2 20216829 PTHR21181:SF7 ER membrane protein complex subunit 5-related ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;EMC complex#GO:0072546 HELRO|EnsemblGenome=HelroG80515|UniProtKB=T1G416 T1G416 20215814 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG165911|UniProtKB=T1EXF9 T1EXF9 20201259 PTHR10947:SF3 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG80006|UniProtKB=T1G3W4 T1G3W4 20215762 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;actin filament-based process#GO:0030029;cellular component organization#GO:0016043;organelle organization#GO:0006996 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189581|UniProtKB=T1FR62 T1FR62 20211309 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88805|UniProtKB=T1G767 T1G767 20216914 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG126817|UniProtKB=T1EHB1 T1EHB1 20195961 PTHR12403:SF11 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-LIKE PROTEIN Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG92479|UniProtKB=T1G8H1 T1G8H1 20217368 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG158636|UniProtKB=T1EN21 T1EN21 20197971 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122007|UniProtKB=T1EGT5 T1EGT5 20195785 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 response to xenobiotic stimulus#GO:0009410;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to chemical#GO:0042221;response to stimulus#GO:0050896;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466 intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG190076|UniProtKB=T1FRN7 T1FRN7 20211484 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG90028|UniProtKB=T1G7K0 T1G7K0 20217047 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN 7, ISOFORM A binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515 vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;localization#GO:0051179;membrane organization#GO:0061024;biological regulation#GO:0065007;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;regulation of localization#GO:0032879;regulation of transport#GO:0051049;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG90898|UniProtKB=T1G7X7 T1G7X7 20217174 PTHR14413:SF24 RIBOSOMAL PROTEIN L17 LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG183163|UniProtKB=T1FJ87 T1FJ87 20208886 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186366|UniProtKB=T1FNY8 T1FNY8 20210535 PTHR45673:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;protein binding#GO:0005515 calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;calcineurin-mediated signaling#GO:0097720;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein phosphatase#PC00195 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG172391|UniProtKB=T1F589 T1F589 20203988 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG175607|UniProtKB=T1F9F1 T1F9F1 20205450 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG134329|UniProtKB=T1EI44 T1EI44 20196244 PTHR45614:SF315 MYB PROTEIN-RELATED MYB PROTEIN transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell cycle#GO:0007049;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG115501|UniProtKB=T1EG87 T1EG87 20195589 PTHR11604:SF10 PROFILIN PROFILIN protein binding#GO:0005515;actin monomer binding#GO:0003785;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG70377|UniProtKB=T1G057 T1G057 20214455 PTHR43601:SF39 THIOREDOXIN, MITOCHONDRIAL THIOREDOXIN, MITOCHONDRIAL cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG150508|UniProtKB=T1EKF9 T1EKF9 20197059 PTHR47907:SF9 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG91534|UniProtKB=T1G851 T1G851 20217248 PTHR10663:SF342 GUANYL-NUCLEOTIDE EXCHANGE FACTOR FI21420P1 regulation of endocytosis#GO:0030100;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;biological regulation#GO:0065007;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794 postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synaptic membrane#GO:0097060;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG189331|UniProtKB=T1FQY9 T1FQY9 20211236 PTHR11533:SF294 PROTEASE M1 ZINC METALLOPROTEASE THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235 primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG171470|UniProtKB=T1F4B9 T1F4B9 20203668 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG85424|UniProtKB=T1G5W8 T1G5W8 20216465 PTHR24270:SF68 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LD11117P-RELATED endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG76360|UniProtKB=T1G2I9 T1G2I9 20215287 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG176901|UniProtKB=T1FB13 T1FB13 20206012 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG162412|UniProtKB=T1ESM2 T1ESM2 20199572 PTHR12308:SF89 ANOCTAMIN ANOCTAMIN intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128 regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;biological regulation#GO:0065007;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG115758|UniProtKB=T1EGA2 T1EGA2 20195604 PTHR11226:SF0 UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG82753|UniProtKB=T1G4W2 T1G4W2 20216110 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG81315|UniProtKB=T1G4C8 T1G4C8 20215926 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG130000|UniProtKB=T1EHS9 T1EHS9 20196129 PTHR23337:SF3 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 ATPASE MORC2 HELRO|EnsemblGenome=HelroG150771|UniProtKB=T1EKH3 T1EKH3 20197073 PTHR42999:SF1 ANTIBIOTIC RESISTANCE PROTEIN MCBG QUINOLONE RESISTANCE PROTEIN HELRO|EnsemblGenome=HelroG172067|UniProtKB=T1F4Z9 T1F4Z9 20203898 PTHR24056:SF598 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 mitotic cell cycle phase transition#GO:0044772;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell cycle process#GO:0022402;cell cycle#GO:0007049;signaling#GO:0023052;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;G2/M transition of mitotic cell cycle#GO:0000086;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;cell cycle G2/M phase transition#GO:0044839;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625;p53 pathway#P00059>Cdc2#P04634 HELRO|EnsemblGenome=HelroG185388|UniProtKB=T1FMR3 T1FMR3 20210112 PTHR13165:SF0 ARSENITE-RESISTANCE PROTEIN 2 SERRATE RNA EFFECTOR MOLECULE HOMOLOG RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;primary miRNA processing#GO:0031053 intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG103862|UniProtKB=T1EDI0 T1EDI0 20194632 PTHR24115:SF472 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF3A hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;protein binding#GO:0005515;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092 transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;axo-dendritic transport#GO:0008088;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;axonal transport#GO:0098930;organelle assembly#GO:0070925;anterograde axonal transport#GO:0008089;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018 microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185341|UniProtKB=T1FMP5 T1FMP5 20210094 PTHR43323:SF2 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE HYDROXYMETHYLGLUTARYL-COA SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;acetyl-CoA metabolic process#GO:0006084;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637 Cholesterol biosynthesis#P00014>Hydroxymethyl glutaryl CoA synthase#P00498 HELRO|EnsemblGenome=HelroG157627|UniProtKB=T1EME2 T1EME2 20197742 PTHR16160:SF13 FERMITIN 2-RELATED FERMITIN 2-RELATED integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987;cell-substrate adhesion#GO:0031589 cell-substrate junction#GO:0030055;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG183383|UniProtKB=T1FJJ5 T1FJJ5 20208994 PTHR24543:SF339 MULTICOPPER OXIDASE-RELATED LACTADHERIN-LIKE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG161564|UniProtKB=T1ERM2 T1ERM2 20199222 PTHR19307:SF14 TUMOR PROTEIN D52 TUMOR PROTEIN D52 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG66975|UniProtKB=T1FYU4 T1FYU4 20213992 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG164091|UniProtKB=T1EUX0 T1EUX0 20200370 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG122760|UniProtKB=T1EGV6 T1EGV6 20195806 PTHR12974:SF36 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 POLYNUCLEOTIDE ADENYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369 HELRO|EnsemblGenome=HelroG163906|UniProtKB=T1EUL7 T1EUL7 20200267 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to stress#GO:0006950;response to heat#GO:0009408;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;response to stimulus#GO:0050896;protein folding#GO:0006457;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;protein metabolic process#GO:0019538;protein refolding#GO:0042026 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG75909|UniProtKB=T1G2C4 T1G2C4 20215222 PTHR21660:SF1 THIOESTERASE SUPERFAMILY MEMBER-RELATED ACYL-COENZYME A THIOESTERASE 13 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;acyl-CoA hydrolase activity#GO:0016289;deacylase activity#GO:0160215;fatty acyl-CoA hydrolase activity#GO:0047617;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788 metabolite interconversion enzyme#PC00262;esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG84043|UniProtKB=T1G5D8 T1G5D8 20216285 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;L-amino acid transmembrane transporter activity#GO:0015179 amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG193782|UniProtKB=T1FVC7 T1FVC7 20212773 PTHR23339:SF98 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PRL-1 PHOSPHATASE phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG83852|UniProtKB=T1G5B0 T1G5B0 20216257 PTHR45589:SF5 WD REPEAT DOMAIN 62, ISOFORM G WD REPEAT DOMAIN 62, ISOFORM G biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG97866|UniProtKB=T1G9J4 T1G9J4 20217740 PTHR12274:SF3 GRANULIN GRANULIN PRECURSOR extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG79641|UniProtKB=T1G3R7 T1G3R7 20215715 PTHR21024:SF0 GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1 regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG74907|UniProtKB=T1G1X7 T1G1X7 20215075 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG157153|UniProtKB=T1EM71 T1EM71 20197671 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906 lipid metabolic process#GO:0006629;response to xenobiotic stimulus#GO:0009410;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;response to stimulus#GO:0050896;response to chemical#GO:0042221 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG166000|UniProtKB=T1EXK2 T1EXK2 20201302 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG156333|UniProtKB=T1ELT9 T1ELT9 20197539 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626 sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;export from cell#GO:0140352;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;inorganic ion homeostasis#GO:0098771;monoatomic ion transport#GO:0006811;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG141185|UniProtKB=T1EJ28 T1EJ28 20196578 PTHR24416:SF634 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F collagen binding#GO:0005518;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199 regulation of intracellular signal transduction#GO:1902531;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of signaling#GO:0023051;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG111242|UniProtKB=T1EF97 T1EF97 20195249 PTHR11848:SF309 TGF-BETA FAMILY INHIBIN BETA CHAIN signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 BMP/activin signaling pathway-drosophila#P06211>Full-length BMP orthologous ligand#P06256;BMP/activin signaling pathway-drosophila#P06211>BMP/activin orthologous ligand#P06251;Activin beta signaling pathway#P06210>activinbeta full length#P06232;TGF-beta signaling pathway#P00052>TGFbeta#P01286;Activin beta signaling pathway#P06210>activin beta#P06234 HELRO|EnsemblGenome=HelroG81634|UniProtKB=T1G4G8 T1G4G8 20215966 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175534|UniProtKB=T1F9D1 T1F9D1 20205430 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG82785|UniProtKB=T1G4W6 T1G4W6 20216114 PTHR19961:SF81 FIMBRIN/PLASTIN FI19014P1 molecular adaptor activity#GO:0060090;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin binding#GO:0003779;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;actin filament bundle assembly#GO:0051017 intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin filament#GO:0005884;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG192254|UniProtKB=T1FTR7 T1FTR7 20212214 PTHR46290:SF1 DI-N-ACETYLCHITOBIASE DI-N-ACETYLCHITOBIASE HELRO|EnsemblGenome=HelroG193441|UniProtKB=T1FUZ5 T1FUZ5 20212641 PTHR22883:SF514 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC12 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189778|UniProtKB=T1FRD3 T1FRD3 20211380 PTHR19965:SF22 RNA AND EXPORT FACTOR BINDING PROTEIN CHROMATIN TARGET OF PRMT1-LIKE 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185270|UniProtKB=T1FML1 T1FML1 20210060 PTHR24068:SF141 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 N transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;protein K63-linked ubiquitination#GO:0070534;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification process#GO:0036211;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Toll receptor signaling pathway#P00054>Ubc13#P01381 HELRO|EnsemblGenome=HelroG173679|UniProtKB=T1F740 T1F740 20204639 PTHR21297:SF0 DNA-DIRECTED RNA POLYMERASE II DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 binding#GO:0005488;translation initiation factor binding#GO:0031369;protein binding#GO:0005515 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG156111|UniProtKB=T1ELR7 T1ELR7 20197517 PTHR45909:SF1 ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;protein localization to Golgi apparatus#GO:0034067;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;Golgi to plasma membrane protein transport#GO:0043001;protein localization to organelle#GO:0033365;Golgi to plasma membrane transport#GO:0006893;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG187805|UniProtKB=T1FPE0 T1FPE0 20210687 PTHR15204:SF0 LARGE PROLINE-RICH PROTEIN BAG6 LARGE PROLINE-RICH PROTEIN BAG6 protein binding#GO:0005515;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG65773|UniProtKB=T1FYC5 T1FYC5 20213823 PTHR12374:SF85 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-ALPHA transcription coactivator activity#GO:0003713;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;binding#GO:0005488;transcription coregulator activity#GO:0003712 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SAGA-type complex#GO:0070461;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG98781|UniProtKB=T1G9P7 T1G9P7 20217793 PTHR10150:SF0 DNA REPAIR ENDONUCLEASE XPF DNA REPAIR ENDONUCLEASE XPF DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;DNA binding#GO:0003677;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;damaged DNA binding#GO:0003684;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788 organelle fission#GO:0048285;sexual reproduction#GO:0019953;recombinational repair#GO:0000725;mitotic recombination#GO:0006312;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;homologous recombination#GO:0035825;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297;resolution of meiotic recombination intermediates#GO:0000712;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleotide-excision repair complex#GO:0000109;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG188265|UniProtKB=T1FPT6 T1FPT6 20210833 PTHR13364:SF6 DEFECTIVE SPERMATOGENESIS PROTEIN 39 SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;vacuolar transport#GO:0007034;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG157302|UniProtKB=T1EM91 T1EM91 20197691 PTHR23290:SF0 RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5 RRNA N(6)-ADENOSINE-METHYLTRANSFERASE METTL5 N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 HELRO|EnsemblGenome=HelroG84234|UniProtKB=T1G5G1 T1G5G1 20216308 PTHR12460:SF0 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN CID DOMAIN-CONTAINING PROTEIN-RELATED RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;binding#GO:0005488 nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG91666|UniProtKB=T1G874 T1G874 20217271 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;anterior/posterior pattern specification#GO:0009952;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG186040|UniProtKB=T1FNK9 T1FNK9 20210406 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 heterochromatin formation#GO:0031507;nuclear migration#GO:0007097;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of macromolecule metabolic process#GO:0060255;localization within membrane#GO:0051668;organelle localization#GO:0051640;localization#GO:0051179;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;protein localization to nucleus#GO:0034504;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;macromolecule localization#GO:0033036;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;transport#GO:0006810;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;intracellular protein localization#GO:0008104;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;establishment of organelle localization#GO:0051656;cellular localization#GO:0051641;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840 intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;nucleus#GO:0005634;nuclear lumen#GO:0031981;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 HELRO|EnsemblGenome=HelroG68312|UniProtKB=T1FZC9 T1FZC9 20214177 PTHR11626:SF8 FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE SQUALENE SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 isoprenoid metabolic process#GO:0006720;terpenoid metabolic process#GO:0006721;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 transferase#PC00220 Cholesterol biosynthesis#P00014>Farnesyl-diphosphate farnesyltransferase#P00499 HELRO|EnsemblGenome=HelroG161934|UniProtKB=T1ES19 T1ES19 20199369 PTHR47204:SF1 OS02G0168900 PROTEIN PHAGE TAIL PROTEIN HELRO|EnsemblGenome=HelroG99230|UniProtKB=T1G9R6 T1G9R6 20217812 PTHR18919:SF153 ACETYL-COA C-ACYLTRANSFERASE TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;lipid modification#GO:0030258 mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;transferase complex#GO:1990234 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG159832|UniProtKB=T1EPG4 T1EPG4 20198464 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG119465|UniProtKB=T1EGN3 T1EGN3 20195733 PTHR10352:SF83 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FI04408P biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG76592|UniProtKB=T1G2M0 T1G2M0 20215318 PTHR12276:SF115 EPSIN/ENT-RELATED FI19443P1 lipid binding#GO:0008289;protein binding#GO:0005515;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;vesicle coat#GO:0030120;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;clathrin-coated vesicle#GO:0030136;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG175388|UniProtKB=T1F981 T1F981 20205380 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG166565|UniProtKB=T1EY93 T1EY93 20201543 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG79826|UniProtKB=T1G3T9 T1G3T9 20215737 PTHR12294:SF13 EF HAND DOMAIN FAMILY A1,A2-RELATED MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 mitochondrial calcium ion homeostasis#GO:0051560;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;transporter complex#GO:1990351;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG176275|UniProtKB=T1FAC8 T1FAC8 20205777 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165857|UniProtKB=T1EXD3 T1EXD3 20201233 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;muscle system process#GO:0003012;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;system process#GO:0003008;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;muscle contraction#GO:0006936;actin filament-based process#GO:0030029 organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG140466|UniProtKB=T1EJ11 T1EJ11 20196561 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG179444|UniProtKB=T1FEQ3 T1FEQ3 20207302 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189028|UniProtKB=T1FQK6 T1FQK6 20211103 PTHR24230:SF158 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;neuropeptide signaling pathway#GO:0007218 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG157541|UniProtKB=T1EMD0 T1EMD0 20197730 PTHR10766:SF177 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1 macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG82651|UniProtKB=T1G4U8 T1G4U8 20216096 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG112374|UniProtKB=T1EFJ2 T1EFJ2 20195344 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG173500|UniProtKB=T1F6W5 T1F6W5 20204564 PTHR24637:SF422 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188761|UniProtKB=T1FQC1 T1FQC1 20211018 PTHR15730:SF8 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED TRPM8 CHANNEL-ASSOCIATED FACTOR HOMOLOG-RELATED transmembrane transporter binding#GO:0044325;binding#GO:0005488;protein binding#GO:0005515 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG163785|UniProtKB=T1EUH1 T1EUH1 20200221 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG173282|UniProtKB=T1F6M7 T1F6M7 20204476 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG133020|UniProtKB=T1EI02 T1EI02 20196202 PTHR24392:SF56 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG105910|UniProtKB=T1EDY5 T1EDY5 20194787 PTHR14237:SF19 MOLYBDOPTERIN COFACTOR SULFURASE MOSC FI02892P HELRO|EnsemblGenome=HelroG160322|UniProtKB=T1EQ36 T1EQ36 20198686 PTHR24135:SF30 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN LD13733P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor complex adaptor activity#GO:0030159;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;synapse organization#GO:0050808;cellular component organization#GO:0016043 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;dendritic spine#GO:0043197;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;postsynaptic membrane#GO:0045211;dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069 scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HELRO|EnsemblGenome=HelroG113277|UniProtKB=T1EFR3 T1EFR3 20195415 PTHR21245:SF10 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN PROTEIN TUMOROUS TESTIS-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG88036|UniProtKB=T1G6X6 T1G6X6 20216823 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] metal ion binding#GO:0046872;lyase activity#GO:0016829;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830 small molecule biosynthetic process#GO:0044283;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;response to nutrient levels#GO:0031667;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;response to glucose#GO:0009749;hexose biosynthetic process#GO:0019319;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;cellular response to glucose stimulus#GO:0071333;monosaccharide metabolic process#GO:0005996;alcohol metabolic process#GO:0006066;glucose homeostasis#GO:0042593;glucose metabolic process#GO:0006006;cellular response to oxygen-containing compound#GO:1901701;gluconeogenesis#GO:0006094;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;response to stress#GO:0006950;carbohydrate biosynthetic process#GO:0016051;response to chemical#GO:0042221;response to lipid#GO:0033993;response to oxygen-containing compound#GO:1901700;response to monosaccharide#GO:0034284;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;intracellular glucose homeostasis#GO:0001678;response to carbohydrate#GO:0009743;carbohydrate homeostasis#GO:0033500;response to hexose#GO:0009746;carboxylic acid metabolic process#GO:0019752;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG170601|UniProtKB=T1F383 T1F383 20203282 PTHR31542:SF1 39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML50 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG192229|UniProtKB=T1FTQ8 T1FTQ8 20212205 PTHR24030:SF0 PROTEIN CMSS1 PROTEIN CMSS1 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular process#GO:0009987 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG186833|UniProtKB=T1FP40 T1FP40 20210587 PTHR11349:SF116 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE B kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550 cellular process#GO:0009987;metabolic process#GO:0008152;nucleoside triphosphate biosynthetic process#GO:0009142;phosphorus metabolic process#GO:0006793;biosynthetic process#GO:0009058;nucleoside triphosphate metabolic process#GO:0009141 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;kinase#PC00137 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156;De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912 HELRO|EnsemblGenome=HelroG162950|UniProtKB=T1ETE8 T1ETE8 20199848 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG117164|UniProtKB=T1EGK7 T1EGK7 20195707 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG159908|UniProtKB=T1EPJ6 T1EPJ6 20198496 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG85046|UniProtKB=T1G5S0 T1G5S0 20216417 PTHR15323:SF6 D123 PROTEIN TRANSLATION INITIATION FACTOR EIF2 ASSEMBLY PROTEIN cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG169769|UniProtKB=T1F2B3 T1F2B3 20202963 PTHR10161:SF14 TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 hydrolase activity#GO:0016787;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;phosphoric ester hydrolase activity#GO:0042578;iron ion binding#GO:0005506;acid phosphatase activity#GO:0003993;catalytic activity#GO:0003824;ferrous iron binding#GO:0008198;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG162498|UniProtKB=T1ESR2 T1ESR2 20199612 PTHR46532:SF4 MALE FERTILITY FACTOR KL5 DYNEIN HEAVY CHAIN, CYTOPLASMIC Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG183799|UniProtKB=T1FK76 T1FK76 20209225 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74014|UniProtKB=T1G1L1 T1G1L1 20214959 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG111477|UniProtKB=T1EFB7 T1EFB7 20195269 PTHR24118:SF99 POTE ANKYRIN DOMAIN CHARON membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166371|UniProtKB=T1EY24 T1EY24 20201474 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993 HELRO|EnsemblGenome=HelroG82366|UniProtKB=T1G4R2 T1G4R2 20216060 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157200|UniProtKB=T1EM80 T1EM80 20197680 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG167653|UniProtKB=T1EZM6 T1EZM6 20202026 PTHR24203:SF95 ANKYRIN REPEAT FAMILY PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6 ISOFORM X1-RELATED cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;establishment or maintenance of cell polarity#GO:0007163;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 HELRO|EnsemblGenome=HelroG81900|UniProtKB=T1G4K4 T1G4K4 20216002 PTHR24057:SF82 GLYCOGEN SYNTHASE KINASE-3 ALPHA PROTEIN KINASE SHAGGY-RELATED catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;cellular developmental process#GO:0048869;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;regulation of microtubule-based process#GO:0032886;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of signal transduction#GO:0009968;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;positive regulation of proteasomal protein catabolic process#GO:1901800;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PDGF signaling pathway#P00047>GSK3#P01153;Angiogenesis#P00005>GSK3beta#P00211;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175 HELRO|EnsemblGenome=HelroG171432|UniProtKB=T1F498 T1F498 20203647 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 ligase#PC00142 HELRO|EnsemblGenome=HelroG114062|UniProtKB=T1EFY6 T1EFY6 20195488 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG184651|UniProtKB=T1FLP1 T1FLP1 20209740 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194084|UniProtKB=T1FVN4 T1FVN4 20212880 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG74464|UniProtKB=T1G1R4 T1G1R4 20215012 PTHR12861:SF3 TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166414|UniProtKB=T1EY40 T1EY40 20201490 PTHR12197:SF251 HISTONE-LYSINE N-METHYLTRANSFERASE SMYD EG:BACR7C10.4 PROTEIN S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG179484|UniProtKB=T1FES4 T1FES4 20207323 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG62457|UniProtKB=T1FX09 T1FX09 20213357 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG163136|UniProtKB=T1ETP7 T1ETP7 20199947 PTHR24034:SF111 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE64043P cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG178827|UniProtKB=T1FDS9 T1FDS9 20206978 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED LD39025P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG80673|UniProtKB=T1G438 T1G438 20215836 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG68427|UniProtKB=T1FZE5 T1FZE5 20214193 PTHR43245:SF11 BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA LD23561P HELRO|EnsemblGenome=HelroG114375|UniProtKB=T1EG11 T1EG11 20195513 PTHR11085:SF20 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;NAD-dependent protein lysine deacetylase activity#GO:0034979;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone deacetylase activity#GO:0004407;deacylase activity#GO:0160215;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;acyltransferase activity#GO:0016746 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG186739|UniProtKB=T1FP28 T1FP28 20210575 PTHR10480:SF12 PROTEIN UNC-13 HOMOLOG UNC-13, ISOFORM E SNARE binding#GO:0000149;calmodulin binding#GO:0005516;binding#GO:0005488;syntaxin binding#GO:0019905;protein binding#GO:0005515 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG155148|UniProtKB=T1ELH3 T1ELH3 20197423 PTHR46138:SF1 PROTEIN DR1 PROTEIN DR1 transcription factor binding#GO:0008134;binding#GO:0005488;protein binding#GO:0005515 protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG102816|UniProtKB=T1EDC1 T1EDC1 20194573 PTHR14187:SF46 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12A HELRO|EnsemblGenome=HelroG181317|UniProtKB=T1FGW1 T1FGW1 20208060 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193096|UniProtKB=T1FUM5 T1FUM5 20212521 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG182860|UniProtKB=T1FIV8 T1FIV8 20208757 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG184783|UniProtKB=T1FLZ6 T1FLZ6 20209845 PTHR46579:SF5 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158785|UniProtKB=T1EN94 T1EN94 20198044 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183406|UniProtKB=T1FJK9 T1FJK9 20209008 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG163684|UniProtKB=T1EUC8 T1EUC8 20200178 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;cell migration#GO:0016477;cell motility#GO:0048870;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG109972|UniProtKB=T1EEY0 T1EEY0 20195132 PTHR45840:SF8 RHOMBOID-RELATED PROTEIN RHOMBOID-4 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG69872|UniProtKB=T1FZZ1 T1FZZ1 20214389 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A8-LIKE monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG193788|UniProtKB=T1FVC8 T1FVC8 20212774 PTHR14456:SF2 INOSITOL POLYPHOSPHATE KINASE 1 INOSITOL-PENTAKISPHOSPHATE 2-KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 kinase#PC00137 HELRO|EnsemblGenome=HelroG133388|UniProtKB=T1EI08 T1EI08 20196208 PTHR11544:SF148 COLD SHOCK DOMAIN CONTAINING PROTEINS LD37574P binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG162157|UniProtKB=T1ESA5 T1ESA5 20199455 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG166935|UniProtKB=T1EYS0 T1EYS0 20201720 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113731|UniProtKB=T1EFV7 T1EFV7 20195459 PTHR12625:SF0 LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR PROTEIN LILIPOD signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG84941|UniProtKB=T1G5Q7 T1G5Q7 20216404 PTHR14167:SF124 SH3 DOMAIN-CONTAINING ENDOPHILIN-A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cytoplasm#GO:0005737;cytosol#GO:0005829;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG74648|UniProtKB=T1G1T6 T1G1T6 20215034 PTHR24056:SF171 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 20 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174907|UniProtKB=T1F8L7 T1F8L7 20205166 PTHR12692:SF8 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED GH11935P protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;metal ion transport#GO:0030001;monoatomic cation transport#GO:0006812;localization#GO:0051179;protein metabolic process#GO:0019538;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;metabolic process#GO:0008152;magnesium ion transport#GO:0015693;glycoprotein metabolic process#GO:0009100;transport#GO:0006810;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;carbohydrate derivative biosynthetic process#GO:1901137 cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG89958|UniProtKB=T1G7J6 T1G7J6 20217043 PTHR12871:SF0 BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG104797|UniProtKB=T1EDN7 T1EDN7 20194689 PTHR47979:SF137 DRAB11-RELATED RAB11 purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endosome#GO:0005768 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG184989|UniProtKB=T1FM85 T1FM85 20209934 PTHR11703:SF0 DEOXYHYPUSINE SYNTHASE DEOXYHYPUSINE SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 biogenic amine metabolic process#GO:0006576;metabolic process#GO:0008152;amine metabolic process#GO:0009308;polyamine metabolic process#GO:0006595;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG177542|UniProtKB=T1FBV0 T1FBV0 20206299 PTHR46660:SF2 FAMILY NOT NAMED GLYCOSYLTRANSFERASE 1 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG179323|UniProtKB=T1FEJ6 T1FEJ6 20207245 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG154960|UniProtKB=T1ELG7 T1ELG7 20197417 PTHR11848:SF263 TGF-BETA FAMILY PROTEIN DECAPENTAPLEGIC receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 DPP signaling pathway#P06213>DPP#P06285;DPP-SCW signaling pathway#P06212>DPP full length#P06273;BMP/activin signaling pathway-drosophila#P06211>Full-length BMP orthologous ligand#P06256;BMP/activin signaling pathway-drosophila#P06211>BMP/activin orthologous ligand#P06251;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP-SCW signaling pathway#P06212>DPP#P06272;DPP signaling pathway#P06213>DPP full length#P06282 HELRO|EnsemblGenome=HelroG98446|UniProtKB=T1G9M8 T1G9M8 20217774 PTHR14986:SF4 RURM1 PROTEIN UBIQUITIN-RELATED MODIFIER 1 post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG164811|UniProtKB=T1EVU3 T1EVU3 20200693 PTHR10075:SF119 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG168693|UniProtKB=T1F0V3 T1F0V3 20202453 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG84522|UniProtKB=T1G5J6 T1G5J6 20216343 PTHR21107:SF2 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19 mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617 intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG65946|UniProtKB=T1FYE8 T1FYE8 20213846 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;chloride transmembrane transport#GO:1902476;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG70308|UniProtKB=T1G044 T1G044 20214442 PTHR43840:SF13 MITOCHONDRIAL METAL TRANSPORTER 1-RELATED CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG163956|UniProtKB=T1EUN6 T1EUN6 20200286 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194205|UniProtKB=T1FVS9 T1FVS9 20212925 PTHR15758:SF2 BCL-2-LIKE PROTEIN 13 BCL-2-LIKE PROTEIN 13 HELRO|EnsemblGenome=HelroG81612|UniProtKB=T1G4G5 T1G4G5 20215963 PTHR11728:SF8 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG79322|UniProtKB=T1G3M7 T1G3M7 20215675 PTHR14167:SF76 SH3 DOMAIN-CONTAINING ENDOPHILIN B, ISOFORM A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155823|UniProtKB=T1ELM8 T1ELM8 20197478 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG168923|UniProtKB=T1F150 T1F150 20202550 PTHR21522:SF32 PROTON CHANNEL OTOP PROTON CHANNEL OTOPLC monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;proton channel activity#GO:0015252;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078 monoatomic ion transport#GO:0006811;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG78681|UniProtKB=T1G3E6 T1G3E6 20215594 PTHR23049:SF80 MYOSIN REGULATORY LIGHT CHAIN 2 EF-HAND DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG162367|UniProtKB=T1ESK6 T1ESK6 20199556 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82642|UniProtKB=T1G4U5 T1G4U5 20216093 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG93282|UniProtKB=T1G8U9 T1G8U9 20217496 PTHR10286:SF92 INORGANIC PYROPHOSPHATASE INORGANIC PYROPHOSPHATASE hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 metabolic process#GO:0008152;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 pyrophosphatase#PC00196 HELRO|EnsemblGenome=HelroG158846|UniProtKB=T1ENC0 T1ENC0 20198070 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166761|UniProtKB=T1EYH5 T1EYH5 20201625 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173726|UniProtKB=T1F761 T1F761 20204660 PTHR14625:SF3 MICROCEPHALIN MICROCEPHALIN mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle#GO:0007049 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG191792|UniProtKB=T1FTB9 T1FTB9 20212066 PTHR10127:SF911 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;developmental process#GO:0032502;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;regionalization#GO:0003002;biosynthetic process#GO:0009058;proteolysis#GO:0006508;pattern specification process#GO:0007389;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;primary metabolic process#GO:0044238;dorsal/ventral pattern formation#GO:0009953 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 SCW signaling pathway#P06216>TLD#P06327;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP signaling pathway#P06213>TLD#P06283;BMP/activin signaling pathway-drosophila#P06211>TLD#P06249;DPP-SCW signaling pathway#P06212>TLD#P06264 HELRO|EnsemblGenome=HelroG102359|UniProtKB=T1ED97 T1ED97 20194549 PTHR24115:SF973 KINESIN-RELATED KINESIN MOTOR DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887 establishment of localization#GO:0051234;transport along microtubule#GO:0010970;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based process#GO:0007017;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188820|UniProtKB=T1FQE3 T1FQE3 20211040 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG70304|UniProtKB=T1G042 T1G042 20214440 PTHR14200:SF11 CYTOCHROME C OXIDASE POLYPEPTIDE CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119 catalytic complex#GO:1902494;transporter complex#GO:1990351;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;oxidase#PC00175 HELRO|EnsemblGenome=HelroG173260|UniProtKB=T1F6M2 T1F6M2 20204471 PTHR11961:SF56 CYTOCHROME C CYTOCHROME C generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013 ATP synthesis#P02721>Cyt C#P02798;Apoptosis signaling pathway#P00006>Cytochrome C#P00322 HELRO|EnsemblGenome=HelroG153251|UniProtKB=T1EL17 T1EL17 20197267 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161462|UniProtKB=T1ERH9 T1ERH9 20199179 PTHR11804:SF79 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED MITOCHONDRIAL INTERMEDIATE PEPTIDASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG105249|UniProtKB=T1EDS2 T1EDS2 20194724 PTHR22624:SF60 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;protein-phosphatidylethanolamide deconjugating activity#GO:0019786;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;proteolysis#GO:0006508;organelle assembly#GO:0070925;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;protein metabolic process#GO:0019538;autophagy#GO:0006914;protein processing#GO:0016485;autophagosome organization#GO:1905037;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG153199|UniProtKB=T1EL08 T1EL08 20197258 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109533|UniProtKB=T1EEU5 T1EEU5 20195097 PTHR45827:SF1 SORTING NEXIN SORTING NEXIN ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;endocytosis#GO:0006897;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;plasma membrane organization#GO:0007009 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG112678|UniProtKB=T1EFL3 T1EFL3 20195365 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;kinase binding#GO:0019900;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169 positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of carbohydrate biosynthetic process#GO:0043255;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of carbohydrate metabolic process#GO:0006109;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG117118|UniProtKB=T1EGK3 T1EGK3 20195704 PTHR10194:SF142 RAS GTPASE-ACTIVATING PROTEINS NEUROFIBROMIN GTPase-activating protein#PC00257 EGF receptor signaling pathway#P00018>GAP#P00546 HELRO|EnsemblGenome=HelroG94263|UniProtKB=T1G8Z8 T1G8Z8 20217545 PTHR21311:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8 Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;retrograde transport, vesicle recycling within Golgi#GO:0000301;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;COG complex#GO:0017119;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG168913|UniProtKB=T1F145 T1F145 20202545 PTHR11571:SF230 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE-RELATED transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790 transferase#PC00220 HELRO|EnsemblGenome=HelroG178679|UniProtKB=T1FDK2 T1FDK2 20206901 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG186577|UniProtKB=T1FP13 T1FP13 20210560 PTHR43511:SF4 FAMILY NOT NAMED UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE HELRO|EnsemblGenome=HelroG132794|UniProtKB=T1EHZ6 T1EHZ6 20196196 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG144670|UniProtKB=T1EJF7 T1EJF7 20196707 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG73705|UniProtKB=T1G1H5 T1G1H5 20214923 PTHR46359:SF2 GEO07743P1 GEO07743P1 HELRO|EnsemblGenome=HelroG177069|UniProtKB=T1FB73 T1FB73 20206072 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG192840|UniProtKB=T1FUC6 T1FUC6 20212422 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;DNA binding#GO:0003677;chromatin DNA binding#GO:0031490;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;transcription regulator activity#GO:0140110;binding#GO:0005488;acetyltransferase activity#GO:0016407;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;transcription coactivator activity#GO:0003713 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;DPP-SCW signaling pathway#P06212>NEJ#P06260;p53 pathway#P00059>CBP#P04623;Huntington disease#P00029>CBP#P00777;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;DPP signaling pathway#P06213>NEJ#P06284;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295 HELRO|EnsemblGenome=HelroG167528|UniProtKB=T1EZG5 T1EZG5 20201965 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG179236|UniProtKB=T1FEE7 T1FEE7 20207196 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185001|UniProtKB=T1FM93 T1FM93 20209942 PTHR30244:SF34 TRANSAMINASE UDP-4-AMINO-4-DEOXY-L-ARABINOSE--OXOGLUTARATE AMINOTRANSFERASE transaminase activity#GO:0008483;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;transferase activity#GO:0016740;catalytic activity#GO:0003824 polysaccharide biosynthetic process#GO:0000271;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976 transaminase#PC00216 HELRO|EnsemblGenome=HelroG185193|UniProtKB=T1FMH6 T1FMH6 20210025 PTHR12866:SF2 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;catabolic process#GO:0009056;glucan catabolic process#GO:0009251;carbohydrate metabolic process#GO:0005975;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;organelle organization#GO:0006996;glycogen catabolic process#GO:0005980;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;macromolecule catabolic process#GO:0009057;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;autophagosome assembly#GO:0000045 phagophore assembly site#GO:0000407;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG190270|UniProtKB=T1FRU4 T1FRU4 20211541 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746 HELRO|EnsemblGenome=HelroG97197|UniProtKB=T1G9F9 T1G9F9 20217706 PTHR24058:SF112 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG93209|UniProtKB=T1G8U4 T1G8U4 20217491 PTHR10590:SF24 SODIUM/NUCLEOSIDE COTRANSPORTER CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1-RELATED active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;nucleoside transmembrane transporter activity#GO:0005337;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate derivative transmembrane transporter activity#GO:1901505;solute:sodium symporter activity#GO:0015370;nucleobase-containing compound transmembrane transporter activity#GO:0015932;symporter activity#GO:0015293 nucleobase-containing compound transport#GO:0015931;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG168748|UniProtKB=T1F0X1 T1F0X1 20202471 PTHR23354:SF132 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED OXIDATION RESISTANCE PROTEIN 1 response to stress#GO:0006950;response to stimulus#GO:0050896;response to oxidative stress#GO:0006979 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG64929|UniProtKB=T1FY14 T1FY14 20213712 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR ALLATOSTATIN A RECEPTOR 2, ISOFORM A signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG143589|UniProtKB=T1EJA8 T1EJA8 20196658 PTHR47978:SF40 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33 guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG178131|UniProtKB=T1FCT1 T1FCT1 20206630 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178239|UniProtKB=T1FCZ6 T1FCZ6 20206695 PTHR12064:SF97 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM-5 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG110207|UniProtKB=T1EF05 T1EF05 20195157 PTHR23406:SF96 MALIC ENZYME-RELATED MALIC ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG79999|UniProtKB=T1G3W3 T1G3W3 20215761 PTHR12865:SF1 PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;cellular component organization#GO:0016043;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;Golgi organization#GO:0007030;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;endomembrane system organization#GO:0010256;biosynthetic process#GO:0009058;organelle organization#GO:0006996;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vesicle organization#GO:0016050;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endosome#GO:0005768;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;Golgi apparatus#GO:0005794 transferase#PC00220;metabolite interconversion enzyme#PC00262;kinase#PC00137 HELRO|EnsemblGenome=HelroG62904|UniProtKB=T1FX71 T1FX71 20213419 PTHR12309:SF5 SEC61 GAMMA SUBUNIT PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA transmembrane protein transporter activity#GO:0008320;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;post-translational protein targeting to membrane, translocation#GO:0031204;protein transport#GO:0015031;localization within membrane#GO:0051668;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein targeting to ER#GO:0045047;protein targeting to membrane#GO:0006612;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;establishment of protein localization to endoplasmic reticulum#GO:0072599;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;rough endoplasmic reticulum membrane#GO:0030867;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;rough endoplasmic reticulum#GO:0005791;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum protein-containing complex#GO:0140534 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG188494|UniProtKB=T1FQ20 T1FQ20 20210917 PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triacylglycerol lipase activity#GO:0004806 catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;cellular process#GO:0009987;lipid catabolic process#GO:0016042;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;acylglycerol metabolic process#GO:0006639;glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;triglyceride catabolic process#GO:0019433 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HELRO|EnsemblGenome=HelroG69935|UniProtKB=T1G001 T1G001 20214399 PTHR10707:SF10 CYTOCHROME C OXIDASE SUBUNIT IV CYTOCHROME C OXIDASE SUBUNIT 4 respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773 organelle membrane#GO:0031090;transporter complex#GO:1990351;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;organelle envelope#GO:0031967 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG161703|UniProtKB=T1ERS9 T1ERS9 20199279 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG67244|UniProtKB=T1FYY8 T1FYY8 20214036 PTHR43220:SF21 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 41A HELRO|EnsemblGenome=HelroG189324|UniProtKB=T1FQY4 T1FQY4 20211231 PTHR24161:SF130 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177827|UniProtKB=T1FCC0 T1FCC0 20206469 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG101038|UniProtKB=T1ED27 T1ED27 20194479 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG162999|UniProtKB=T1ETJ1 T1ETJ1 20199891 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178467|UniProtKB=T1FD75 T1FD75 20206774 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG165664|UniProtKB=T1EX54 T1EX54 20201154 PTHR20908:SF1 LD15586P LD15586P HELRO|EnsemblGenome=HelroG88458|UniProtKB=T1G729 T1G729 20216876 PTHR13952:SF6 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN RNA binding#GO:0003723;snRNA binding#GO:0017069;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG192359|UniProtKB=T1FTV0 T1FTV0 20212247 PTHR24343:SF304 SERINE/THREONINE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166358|UniProtKB=T1EY19 T1EY19 20201469 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG174494|UniProtKB=T1F868 T1F868 20205017 PTHR18934:SF83 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16 isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG101134|UniProtKB=T1ED31 T1ED31 20194483 PTHR12093:SF12 NCK-ASSOCIATED PROTEIN 1 MEMBRANE-ASSOCIATED PROTEIN HEM cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cell migration#GO:0016477;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;system development#GO:0048731;cortical actin cytoskeleton organization#GO:0030866;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG71280|UniProtKB=T1G0I9 T1G0I9 20214587 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG188199|UniProtKB=T1FPR8 T1FPR8 20210815 PTHR43807:SF23 FI04487P FI04487P transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160696|UniProtKB=T1EQM1 T1EQM1 20198871 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG113279|UniProtKB=T1EFR4 T1EFR4 20195416 PTHR11675:SF101 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG186013|UniProtKB=T1FNJ7 T1FNJ7 20210394 PTHR13608:SF3 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG111260|UniProtKB=T1EFA0 T1EFA0 20195252 PTHR45670:SF1 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 E3 UBIQUITIN-PROTEIN LIGASE HECTD1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG77014|UniProtKB=T1G2S4 T1G2S4 20215372 PTHR13180:SF0 SMALL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 50B retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197 cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG66108|UniProtKB=T1FYH1 T1FYH1 20213869 PTHR11206:SF153 MULTIDRUG RESISTANCE PROTEIN ETHIONINE RESISTANCE-CONFERRING PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG62285|UniProtKB=T1FWY7 T1FWY7 20213335 PTHR48051:SF61 FAMILY NOT NAMED LEUCINE-RICH REPEAT PROTEIN LRRA-LIKE intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG166764|UniProtKB=T1EYH6 T1EYH6 20201626 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87424|UniProtKB=T1G6P8 T1G6P8 20216745 PTHR24322:SF755 PKSB RETINOL DEHYDROGENASE 10 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG188294|UniProtKB=T1FPU3 T1FPU3 20210840 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94516|UniProtKB=T1G916 T1G916 20217563 PTHR10894:SF1 NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58 NUCLEOLAR PROTEIN 58 RNA binding#GO:0003723;snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;binding#GO:0005488 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174039|UniProtKB=T1F7I4 T1F7I4 20204783 PTHR22950:SF652 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171 amino acid transport#GO:0006865;cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cellular anatomical structure#GO:0110165 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG71793|UniProtKB=T1G0R8 T1G0R8 20214666 PTHR12563:SF17 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG168557|UniProtKB=T1F0Q4 T1F0Q4 20202404 PTHR14309:SF10 EXPRESSED PROTEIN PH DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG88955|UniProtKB=T1G776 T1G776 20216923 PTHR24351:SF249 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188923|UniProtKB=T1FQH3 T1FQH3 20211070 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;homeostatic process#GO:0042592;export from cell#GO:0140352;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;inorganic ion homeostasis#GO:0098771;monoatomic cation transport#GO:0006812;potassium ion homeostasis#GO:0055075;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG171239|UniProtKB=T1F3Z4 T1F3Z4 20203543 PTHR22948:SF84 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED spermatogenesis#GO:0007283;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;cell maturation#GO:0048469;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;developmental maturation#GO:0021700;regionalization#GO:0003002;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;pattern specification process#GO:0007389;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;anterior/posterior pattern specification#GO:0009952;nucleobase-containing compound biosynthetic process#GO:0034654;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anterior/posterior axis specification#GO:0009948;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;embryonic pattern specification#GO:0009880;RNA processing#GO:0006396;embryo development#GO:0009790;oogenesis#GO:0048477;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cell differentiation#GO:0030154;gamete generation#GO:0007276 intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG99171|UniProtKB=T1G9R2 T1G9R2 20217808 PTHR11390:SF20 PROKARYOTIC DNA TOPOISOMERASE DNA TOPOISOMERASE 3-BETA-1 nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853 cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG174648|UniProtKB=T1F8C6 T1F8C6 20205075 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG187984|UniProtKB=T1FPI8 T1FPI8 20210735 PTHR24026:SF141 FAT ATYPICAL CADHERIN-RELATED CADHERIN DOMAIN-CONTAINING PROTEIN cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;developmental process#GO:0032502 cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG171049|UniProtKB=T1F3R1 T1F3R1 20203460 PTHR15955:SF8 RWD DOMAIN CONTAINING PROTEIN 2 RWD DOMAIN-CONTAINING PROTEIN 2B ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191239|UniProtKB=T1FSS1 T1FSS1 20211868 PTHR18839:SF0 MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 MISP FAMILY MEMBER MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 ISOFORM X1 HELRO|EnsemblGenome=HelroG176969|UniProtKB=T1FB30 T1FB30 20206029 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG173095|UniProtKB=T1F6C2 T1F6C2 20204371 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72205|UniProtKB=T1G0X1 T1G0X1 20214719 PTHR12907:SF26 EGL NINE HOMOLOG-RELATED HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASE HELRO|EnsemblGenome=HelroG98804|UniProtKB=T1G9P9 T1G9P9 20217795 PTHR22807:SF30 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;rRNA base methylation#GO:0070475;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA methylation#GO:0031167 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG79936|UniProtKB=T1G3V2 T1G3V2 20215750 PTHR14269:SF60 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CARDIOLIPIN SYNTHASE (CMP-FORMING) transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772 organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid biosynthetic process#GO:0008654;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;phosphatidylglycerol biosynthetic process#GO:0006655;phospholipid metabolic process#GO:0006644;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG177142|UniProtKB=T1FB96 T1FB96 20206095 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG108462|UniProtKB=T1EEJ2 T1EEJ2 20194994 PTHR14149:SF14 RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;enzyme activator activity#GO:0008047;calmodulin binding#GO:0005516;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;enzyme regulator activity#GO:0030234 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;actin filament organization#GO:0007015;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;actomyosin contractile ring assembly#GO:0000915;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;mitotic cytokinetic process#GO:1902410;cytoskeleton-dependent cytokinesis#GO:0061640;cortical actin cytoskeleton organization#GO:0030866;supramolecular fiber organization#GO:0097435;cortical cytoskeleton organization#GO:0030865;cytokinesis#GO:0000910;actin filament-based process#GO:0030029;cytokinetic process#GO:0032506;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell division#GO:0051301;cell cycle process#GO:0022402 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;cell cortex#GO:0005938 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG69972|UniProtKB=T1G008 T1G008 20214406 PTHR10472:SF1 D-TYROSYL-TRNA TYR DEACYLASE D-AMINOACYL-TRNA DEACYLASE 2 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;deacylase activity#GO:0160215;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 esterase#PC00097;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG133386|UniProtKB=T1EI07 T1EI07 20196207 PTHR24416:SF640 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN VER-1-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG150039|UniProtKB=T1EKE0 T1EKE0 20197040 PTHR23280:SF25 4.1 G PROTEIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG89522|UniProtKB=T1G7E0 T1G7E0 20216987 PTHR13305:SF0 RIBOSOME BIOGENESIS PROTEIN NOP10 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 snRNA processing#GO:0016180;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;rRNA modification#GO:0000154;pseudouridine synthesis#GO:0001522;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG75798|UniProtKB=T1G2A4 T1G2A4 20215202 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG72133|UniProtKB=T1G0W3 T1G0W3 20214711 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG193806|UniProtKB=T1FVD6 T1FVD6 20212782 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG176915|UniProtKB=T1FB16 T1FB16 20206015 PTHR34929:SF5 ZGC:153157 TRANSMEMBRANE PROTEIN INAFM2 HELRO|EnsemblGenome=HelroG163608|UniProtKB=T1EUA0 T1EUA0 20200150 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 RNA processing factor#PC00147;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG186091|UniProtKB=T1FNN3 T1FNN3 20210430 PTHR23316:SF28 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;cellular localization#GO:0051641;protein localization to organelle#GO:0033365;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG193801|UniProtKB=T1FVD3 T1FVD3 20212779 PTHR15696:SF7 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 NONSENSE-MEDIATED MRNA DECAY FACTOR nucleic acid binding#GO:0003676;binding#GO:0005488;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164652|UniProtKB=T1EVP2 T1EVP2 20200642 PTHR21340:SF0 DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL] hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside monophosphate biosynthetic process#GO:0009124;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ATP biosynthetic process#GO:0006754;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;organophosphate biosynthetic process#GO:0090407;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG158666|UniProtKB=T1EN38 T1EN38 20197988 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG66723|UniProtKB=T1FYP3 T1FYP3 20213941 PTHR14624:SF0 DFG10 PROTEIN POLYPRENAL REDUCTASE oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;protein N-linked glycosylation#GO:0006487;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG161586|UniProtKB=T1ERN6 T1ERN6 20199236 PTHR13297:SF5 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197 Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG151951|UniProtKB=T1EKN3 T1EKN3 20197133 PTHR36975:SF6 FAMILY NOT NAMED HISTIDINE-RICH GLYCOPROTEIN-LIKE HELRO|EnsemblGenome=HelroG80067|UniProtKB=T1G3X3 T1G3X3 20215771 PTHR12161:SF5 IST1 FAMILY MEMBER IST1 HOMOLOG macromolecule localization#GO:0033036;localization#GO:0051179;intracellular protein localization#GO:0008104 HELRO|EnsemblGenome=HelroG161326|UniProtKB=T1ERC5 T1ERC5 20199125 PTHR11388:SF157 ORGANIC ANION TRANSPORTER ORGANIC ANION TRANSPORTING POLYPEPTIDE 30B, ISOFORM A secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 transporter#PC00227 HELRO|EnsemblGenome=HelroG101736|UniProtKB=T1ED66 T1ED66 20194518 PTHR10799:SF879 SNF2/RAD54 HELICASE FAMILY CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;heterochromatin formation#GO:0031507;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG185455|UniProtKB=T1FMU5 T1FMU5 20210144 PTHR45810:SF10 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HELRO|EnsemblGenome=HelroG83876|UniProtKB=T1G5B2 T1G5B2 20216259 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG174391|UniProtKB=T1F829 T1F829 20204978 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109965|UniProtKB=T1EEX7 T1EEX7 20195129 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857 sensory perception of pain#GO:0019233;sodium ion transport#GO:0006814;action potential#GO:0001508;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;nervous system process#GO:0050877;sensory perception#GO:0007600;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;system process#GO:0003008 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG164225|UniProtKB=T1EV45 T1EV45 20200445 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68975|UniProtKB=T1FZM8 T1FZM8 20214276 PTHR24390:SF271 ZINC FINGER PROTEIN FI23536P1-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG76586|UniProtKB=T1G2L7 T1G2L7 20215315 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG161627|UniProtKB=T1ERQ4 T1ERQ4 20199254 PTHR11086:SF23 DEOXYCYTIDYLATE DEAMINASE-RELATED DEOXYCYTIDYLATE DEAMINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124;small molecule metabolic process#GO:0044281;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121;deaminase#PC00088 HELRO|EnsemblGenome=HelroG93501|UniProtKB=T1G8W1 T1G8W1 20217508 PTHR12730:SF0 HSDA/SDA1-RELATED PROTEIN SDA1 HOMOLOG establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit export from nucleus#GO:0000055;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;organelle localization#GO:0051640;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;transport#GO:0006810 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG156909|UniProtKB=T1EM29 T1EM29 20197629 PTHR11267:SF181 T-BOX PROTEIN-RELATED OPTOMOTOR-BLIND PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG94863|UniProtKB=T1G936 T1G936 20217583 PTHR45721:SF11 LAMIN DM0-RELATED LAMIN-RELATED structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular localization#GO:0051641;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;membrane organization#GO:0061024;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;transport#GO:0006810;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;nucleus organization#GO:0006997;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;intracellular protein localization#GO:0008104;heterochromatin formation#GO:0031507;nuclear migration#GO:0007097;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;organelle localization#GO:0051640;localization within membrane#GO:0051668;localization#GO:0051179 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399 FAS signaling pathway#P00020>Nuclear Lamin#P00616 HELRO|EnsemblGenome=HelroG179041|UniProtKB=T1FE32 T1FE32 20207081 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG77815|UniProtKB=T1G345 T1G345 20215493 PTHR11183:SF204 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN GLUCOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;glucosyltransferase activity#GO:0046527 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG73843|UniProtKB=T1G1J1 T1G1J1 20214939 PTHR22951:SF115 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;clathrin binding#GO:0030276;SNARE binding#GO:0000149;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 receptor-mediated endocytosis#GO:0006898;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 plasma membrane region#GO:0098590;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;clathrin-coated vesicle#GO:0030136;synaptic membrane#GO:0097060;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG184883|UniProtKB=T1FM47 T1FM47 20209896 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364 glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987 transferase#PC00220 HELRO|EnsemblGenome=HelroG194219|UniProtKB=T1FVT7 T1FVT7 20212933 PTHR45965:SF3 INACTIVE RHOMBOID PROTEIN INACTIVE RHOMBOID PROTEIN 1 regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of protein secretion#GO:0050708;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of cell communication#GO:0010646;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of secretion by cell#GO:1903530;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of secretion#GO:0051046 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 serine protease#PC00203 HELRO|EnsemblGenome=HelroG70180|UniProtKB=T1G032 T1G032 20214430 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG168579|UniProtKB=T1F0R4 T1F0R4 20202414 PTHR15116:SF16 DNA-BINDING PROTEIN SATB FAMILY MEMBER DEFECTIVE PROVENTRICULUS, ISOFORM A sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Lambda repressor-like transcription factor#PC00245;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG172568|UniProtKB=T1F5J1 T1F5J1 20204090 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG188065|UniProtKB=T1FPL5 T1FPL5 20210762 PTHR13723:SF306 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG156021|UniProtKB=T1ELQ7 T1ELQ7 20197507 PTHR22069:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN S18 RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG166001|UniProtKB=T1EXK3 T1EXK3 20201303 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193366|UniProtKB=T1FUX2 T1FUX2 20212618 PTHR15140:SF69 TUBULIN-SPECIFIC CHAPERONE E TUBULIN-SPECIFIC CHAPERONE COFACTOR E-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG110634|UniProtKB=T1EF37 T1EF37 20195189 PTHR42923:SF3 PROTOPORPHYRINOGEN OXIDASE PROTOPORPHYRINOGEN OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;oxidase#PC00175 Heme biosynthesis#P02746>Protoporphyrinogen oxidase#P02976 HELRO|EnsemblGenome=HelroG80045|UniProtKB=T1G3X0 T1G3X0 20215768 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 chloride transport#GO:0006821;transport#GO:0006810;chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG86140|UniProtKB=T1G677 T1G677 20216574 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG174252|UniProtKB=T1F7W1 T1F7W1 20204910 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG180773|UniProtKB=T1FG95 T1FG95 20207844 PTHR46660:SF2 FAMILY NOT NAMED GLYCOSYLTRANSFERASE 1 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG180250|UniProtKB=T1FFM8 T1FFM8 20207627 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194137|UniProtKB=T1FVQ8 T1FVQ8 20212904 PTHR14319:SF3 FIVE-SPAN TRANSMEMBRANE PROTEIN M83 TRANSMEMBRANE PROTEIN-LIKE PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG184866|UniProtKB=T1FM36 T1FM36 20209885 PTHR10956:SF0 60S RIBOSOMAL PROTEIN L31 LARGE RIBOSOMAL SUBUNIT PROTEIN EL31 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG91171|UniProtKB=T1G806 T1G806 20217203 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG165072|UniProtKB=T1EW91 T1EW91 20200841 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114226|UniProtKB=T1EG03 T1EG03 20195505 PTHR45783:SF3 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HELRO|EnsemblGenome=HelroG177900|UniProtKB=T1FCG1 T1FCG1 20206510 PTHR34524:SF17 CALCYPHOSIN EF-HAND DOMAIN-CONTAINING PROTEIN calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG189042|UniProtKB=T1FQL1 T1FQL1 20211108 PTHR15751:SF12 TRAFFICKING KINESIN-BINDING PROTEIN TRAFFICKING KINESIN-BINDING PROTEIN MILT cytoskeletal protein binding#GO:0008092;binding#GO:0005488;myosin binding#GO:0017022;protein binding#GO:0005515 transport#GO:0006810;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;vesicle cytoskeletal trafficking#GO:0099518;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle localization#GO:0051648;cellular process#GO:0009987;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;protein targeting#GO:0006605;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;vesicle#GO:0031982;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG83371|UniProtKB=T1G548 T1G548 20216196 PTHR11599:SF246 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;proteasome complex#GO:0000502;cytosol#GO:0005829;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260;protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG108719|UniProtKB=T1EEL7 T1EEL7 20195019 PTHR20974:SF0 UPF0585 PROTEIN CG18661 UPF0585 PROTEIN CG18661 HELRO|EnsemblGenome=HelroG179260|UniProtKB=T1FEG2 T1FEG2 20207211 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171475|UniProtKB=T1F4C1 T1F4C1 20203670 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG87041|UniProtKB=T1G6K8 T1G6K8 20216705 PTHR31488:SF3 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L3 glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG173396|UniProtKB=T1F6S1 T1F6S1 20204520 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188502|UniProtKB=T1FQ22 T1FQ22 20210919 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HELRO|EnsemblGenome=HelroG92277|UniProtKB=T1G8D8 T1G8D8 20217335 PTHR12892:SF11 FGF RECEPTOR ACTIVATING PROTEIN 1 ACYLTRANSFERASE PGAP2 phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;organophosphate metabolic process#GO:0019637;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185484|UniProtKB=T1FMV8 T1FMV8 20210157 PTHR11599:SF237 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-7-1-RELATED macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;proteasome complex#GO:0000502;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG63599|UniProtKB=T1FXI0 T1FXI0 20213528 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185324|UniProtKB=T1FMN9 T1FMN9 20210088 PTHR22093:SF0 LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1 LEUKOCYTE RECEPTOR CLUSTER MEMBER 1 HELRO|EnsemblGenome=HelroG160458|UniProtKB=T1EQ99 T1EQ99 20198749 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG175668|UniProtKB=T1F9H9 T1F9H9 20205478 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG97843|UniProtKB=T1G9J3 T1G9J3 20217739 PTHR43763:SF6 XAA-PRO AMINOPEPTIDASE 1 XAA-PRO AMINOPEPTIDASE 1 protease#PC00190 HELRO|EnsemblGenome=HelroG184089|UniProtKB=T1FKK2 T1FKK2 20209351 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77671|UniProtKB=T1G320 T1G320 20215468 PTHR31854:SF2 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185003|UniProtKB=T1FM95 T1FM95 20209944 PTHR23415:SF29 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT-RELATED cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 cell cycle#GO:0007049;mitotic cell cycle phase transition#GO:0044772;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169944|UniProtKB=T1F2G6 T1F2G6 20203016 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181809|UniProtKB=T1FHC9 T1FHC9 20208228 PTHR24314:SF20 NON-SPECIFIC LIPID TRANSFER PROTEIN-RELATED STEROL CARRIER PROTEIN 2 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG159629|UniProtKB=T1EP95 T1EP95 20198395 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG124735|UniProtKB=T1EH26 T1EH26 20195876 PTHR14677:SF46 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED ubiquitin-dependent protein catabolic process#GO:0006511;protein targeting to ER#GO:0045047;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;establishment of protein localization to endoplasmic reticulum#GO:0072599;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein metabolic process#GO:0019538;localization#GO:0051179;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein targeting#GO:0006605;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG69939|UniProtKB=T1G002 T1G002 20214400 PTHR45910:SF1 N-ALPHA-ACETYLTRANSFERASE 20 N-ALPHA-ACETYLTRANSFERASE 20 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186 regulation of actin filament-based process#GO:0032970;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG164067|UniProtKB=T1EUV3 T1EUV3 20200353 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG157156|UniProtKB=T1EM72 T1EM72 20197672 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG63585|UniProtKB=T1FXH7 T1FXH7 20213525 PTHR31489:SF2 LIN52 FAMILY MEMBER PROTEIN LIN-52 HOMOLOG HELRO|EnsemblGenome=HelroG173090|UniProtKB=T1F6B8 T1F6B8 20204367 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90113|UniProtKB=T1G7L1 T1G7L1 20217058 PTHR23122:SF72 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN anchoring junction#GO:0070161;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81723|UniProtKB=T1G4H9 T1G4H9 20215977 PTHR24171:SF17 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG165704|UniProtKB=T1EX70 T1EX70 20201170 PTHR21580:SF28 SHIPPO-1-RELATED SPERM-TAIL PG-RICH REPEAT FAMILY PROTEIN intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228 structural protein#PC00211 HELRO|EnsemblGenome=HelroG185685|UniProtKB=T1FN53 T1FN53 20210251 PTHR13382:SF10 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B ATP SYNTHASE SUBUNIT S, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG176240|UniProtKB=T1FAB7 T1FAB7 20205766 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG192949|UniProtKB=T1FUG1 T1FUG1 20212457 PTHR22897:SF8 QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE SULFHYDRYL OXIDASE catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;extracellular matrix assembly#GO:0085029;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;protein folding#GO:0006457;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 HELRO|EnsemblGenome=HelroG180860|UniProtKB=T1FGC3 T1FGC3 20207872 PTHR12345:SF16 SYNTENIN RELATED X11L, ISOFORM F-RELATED regulation of biological process#GO:0050789;cellular process#GO:0009987;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell junction#GO:0030054;dendritic spine#GO:0043197;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;synapse#GO:0045202;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG115686|UniProtKB=T1EGA0 T1EGA0 20195602 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG185062|UniProtKB=T1FMC4 T1FMC4 20209973 PTHR42861:SF102 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 metal ion transport#GO:0030001;homeostatic process#GO:0042592;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG182829|UniProtKB=T1FIT6 T1FIT6 20208735 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG102849|UniProtKB=T1EDC4 T1EDC4 20194576 PTHR12611:SF0 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG123616|UniProtKB=T1EGY2 T1EGY2 20195832 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG108721|UniProtKB=T1EEL8 T1EEL8 20195020 PTHR12869:SF0 SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN BOS COMPLEX SUBUNIT TMEM147 HELRO|EnsemblGenome=HelroG81976|UniProtKB=T1G4L2 T1G4L2 20216010 PTHR10556:SF57 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 primary metabolic process#GO:0044238;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;hormone biosynthetic process#GO:0042446;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;steroid biosynthetic process#GO:0006694;regulation of biological quality#GO:0065008 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG171221|UniProtKB=T1F3Y6 T1F3Y6 20203535 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG103366|UniProtKB=T1EDF9 T1EDF9 20194611 PTHR43948:SF10 DNAJ HOMOLOG SUBFAMILY B MRJ, ISOFORM E protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG163606|UniProtKB=T1EU98 T1EU98 20200148 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160227|UniProtKB=T1EQ00 T1EQ00 20198650 PTHR19134:SF572 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG78585|UniProtKB=T1G3D4 T1G3D4 20215582 PTHR12403:SF1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-RELATED cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;TRAPP complex#GO:0030008;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG157952|UniProtKB=T1EMI0 T1EMI0 20197780 PTHR10894:SF0 NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58 NUCLEOLAR PROTEIN 56 binding#GO:0005488;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515;RNA binding#GO:0003723 protein-containing complex#GO:0032991;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG83511|UniProtKB=T1G566 T1G566 20216214 PTHR43899:SF49 RH59310P RH59310P oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG102106|UniProtKB=T1ED80 T1ED80 20194532 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 ligase#PC00142 HELRO|EnsemblGenome=HelroG162619|UniProtKB=T1ESX5 T1ESX5 20199675 PTHR34441:SF1 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG62111|UniProtKB=T1FWW0 T1FWW0 20213308 PTHR23003:SF51 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE-ARGININE PROTEIN 55 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG66673|UniProtKB=T1FYN7 T1FYN7 20213935 PTHR43722:SF1 PROLINE IMINOPEPTIDASE PROLINE IMINOPEPTIDASE catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG180027|UniProtKB=T1FFD1 T1FFD1 20207530 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG97484|UniProtKB=T1G9H1 T1G9H1 20217718 PTHR24056:SF472 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG169105|UniProtKB=T1F1E5 T1F1E5 20202645 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84222|UniProtKB=T1G5G0 T1G5G0 20216307 PTHR23147:SF68 SERINE/ARGININE RICH SPLICING FACTOR SPLICING FACTOR, ARGININE_SERINE-RICH 2-RELATED membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG92504|UniProtKB=T1G8H8 T1G8H8 20217375 PTHR19969:SF19 SH2-SH3 ADAPTOR PROTEIN-RELATED GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 molecular adaptor activity#GO:0060090;receptor tyrosine kinase binding#GO:0030971;protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;signaling receptor binding#GO:0005102;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 biological regulation#GO:0065007;signaling#GO:0023052;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89315|UniProtKB=T1G7C0 T1G7C0 20216967 PTHR10252:SF163 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG176332|UniProtKB=T1FAE4 T1FAE4 20205793 PTHR24104:SF54 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM32-LIKE acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG162689|UniProtKB=T1ET06 T1ET06 20199706 PTHR12449:SF18 DEATH DOMAIN-CONTAINING PROTEIN CARD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162723|UniProtKB=T1ET19 T1ET19 20199719 PTHR21330:SF1 E3 SUMO-PROTEIN LIGASE NSE2 E3 SUMO-PROTEIN LIGASE NSE2 ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;double-strand break repair#GO:0006302;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;condensed chromosome#GO:0000793 HELRO|EnsemblGenome=HelroG170805|UniProtKB=T1F3G3 T1F3G3 20203362 PTHR24067:SF294 UBIQUITIN-CONJUGATING ENZYME E2 PROTEIN CROSSBRONX-LIKE-RELATED catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 primary metabolic process#GO:0044238;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 ubiquitin ligase complex#GO:0000151;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG182646|UniProtKB=T1FIJ3 T1FIJ3 20208642 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185942|UniProtKB=T1FNG8 T1FNG8 20210365 PTHR24073:SF1237 DRAB5-RELATED FI01544P hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 organelle assembly#GO:0070925;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;catabolic process#GO:0009056;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;autophagosome organization#GO:1905037;cellular process#GO:0009987;establishment of protein localization#GO:0045184;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;macroautophagy#GO:0016236;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cell body#GO:0044297;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG172780|UniProtKB=T1F5Y0 T1F5Y0 20204229 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP3 monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG107375|UniProtKB=T1EEA3 T1EEA3 20194905 PTHR21266:SF62 IRON-SULFUR DOMAIN CONTAINING PROTEIN CHOLESTEROL 7-DESATURASE NVD oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG182919|UniProtKB=T1FIX4 T1FIX4 20208773 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185405|UniProtKB=T1FMR9 T1FMR9 20210118 PTHR10443:SF12 MICROSOMAL DIPEPTIDASE DIPEPTIDASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity#GO:0003824 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG162808|UniProtKB=T1ET70 T1ET70 20199770 PTHR19143:SF476 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177977|UniProtKB=T1FCK1 T1FCK1 20206550 PTHR47160:SF13 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191252|UniProtKB=T1FSS9 T1FSS9 20211876 PTHR10648:SF38 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 organelle assembly#GO:0070925;sister chromatid cohesion#GO:0007062;microtubule cytoskeleton organization#GO:0000226;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;chromosome segregation#GO:0007059;meiotic sister chromatid cohesion#GO:0051177;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG130236|UniProtKB=T1EHT4 T1EHT4 20196134 PTHR14009:SF40 LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular component organization#GO:0016043;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;mitochondrial calcium ion transmembrane transport#GO:0006851;organelle organization#GO:0006996;monoatomic ion transmembrane transport#GO:0034220;mitochondrion organization#GO:0007005;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG163640|UniProtKB=T1EUA8 T1EUA8 20200158 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180127|UniProtKB=T1FFH8 T1FFH8 20207577 PTHR37162:SF15 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174430|UniProtKB=T1F842 T1F842 20204991 PTHR11782:SF127 ADENOSINE/GUANOSINE DIPHOSPHATASE NUCLEOSIDE DIPHOSPHATE PHOSPHATASE hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;ribonucleoside triphosphate phosphatase activity#GO:0017111 nucleoside diphosphate metabolic process#GO:0009132;metabolic process#GO:0008152;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181;nucleotide phosphatase#PC00173;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG116093|UniProtKB=T1EGC9 T1EGC9 20195631 PTHR11827:SF103 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 metal ion transport#GO:0030001;monoatomic anion transport#GO:0006820;sodium ion transport#GO:0006814;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;establishment of localization#GO:0051234;chloride transport#GO:0006821;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG171321|UniProtKB=T1F440 T1F440 20203589 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185499|UniProtKB=T1FMW4 T1FMW4 20210163 PTHR24068:SF143 UBIQUITIN-CONJUGATING ENZYME E2 GEO06356P1 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;protein K63-linked ubiquitination#GO:0070534;macromolecule metabolic process#GO:0043170;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Toll receptor signaling pathway#P00054>Uev1A#P01376 HELRO|EnsemblGenome=HelroG164536|UniProtKB=T1EVJ8 T1EVJ8 20200598 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156415|UniProtKB=T1ELV8 T1ELV8 20197558 PTHR13779:SF7 WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER ATPASE WRNIP1 ATP-dependent activity, acting on DNA#GO:0008094;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;molecular function regulator activity#GO:0098772;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;enzyme activator activity#GO:0008047;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;DNA-templated DNA replication#GO:0006261;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG72335|UniProtKB=T1G0Y5 T1G0Y5 20214733 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH19970P-RELATED active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 sodium ion transport#GO:0006814;transport#GO:0006810;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG181678|UniProtKB=T1FH82 T1FH82 20208181 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR TITIN tyrosine protein kinase receptor#PC00233;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG67088|UniProtKB=T1FYW0 T1FYW0 20214008 PTHR21231:SF3 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 2 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein#PC00020;protein-binding activity modulator#PC00095;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG169832|UniProtKB=T1F2C9 T1F2C9 20202979 PTHR12395:SF9 DOM-3 RELATED DECAPPING AND EXORIBONUCLEASE PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity, acting on acid anhydrides#GO:0016817;phosphatase activity#GO:0016791 regulation of biological process#GO:0050789;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;RNA catabolic process#GO:0006401;RNA decapping#GO:0110154;RNA metabolic process#GO:0016070;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG88252|UniProtKB=T1G706 T1G706 20216853 PTHR12510:SF4 TROPONIN C-AKIN-1 PROTEIN GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG158580|UniProtKB=T1EMZ0 T1EMZ0 20197940 PTHR45749:SF35 ZINC FINGER MYM-TYPE PROTEIN 1 AC-LIKE TRANSPOSASE-RELATED HELRO|EnsemblGenome=HelroG193470|UniProtKB=T1FV12 T1FV12 20212658 PTHR42776:SF4 SERINE PEPTIDASE S9 FAMILY MEMBER ACYLAMINO-ACID-RELEASING ENZYME catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG75379|UniProtKB=T1G243 T1G243 20215141 PTHR23113:SF376 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR C molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG193042|UniProtKB=T1FUK0 T1FUK0 20212496 PTHR46358:SF1 TONSOKU-LIKE PROTEIN TONSOKU-LIKE PROTEIN response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;DNA-templated DNA replication#GO:0006261;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;DNA recombination#GO:0006310 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG180266|UniProtKB=T1FFN3 T1FFN3 20207632 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG157080|UniProtKB=T1EM60 T1EM60 20197660 PTHR28080:SF1 PEROXISOMAL BIOGENESIS FACTOR 3 PEROXISOMAL BIOGENESIS FACTOR 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization within membrane#GO:0051668;peroxisome organization#GO:0007031;localization#GO:0051179;cellular localization#GO:0051641;peroxisomal transport#GO:0043574;protein transport#GO:0015031;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777 HELRO|EnsemblGenome=HelroG145946|UniProtKB=T1EJP2 T1EJP2 20196792 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186166|UniProtKB=T1FNR4 T1FNR4 20210461 PTHR11558:SF11 SPERMIDINE/SPERMINE SYNTHASE SPERMIDINE SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 polyamine biosynthetic process#GO:0006596;biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;metabolic process#GO:0008152;amine metabolic process#GO:0009308;polyamine metabolic process#GO:0006595;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220 HELRO|EnsemblGenome=HelroG177498|UniProtKB=T1FBT0 T1FBT0 20206279 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176770|UniProtKB=T1FAW4 T1FAW4 20205963 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG184429|UniProtKB=T1FL68 T1FL68 20209567 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169452|UniProtKB=T1F1Y5 T1F1Y5 20202835 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG83575|UniProtKB=T1G574 T1G574 20216222 PTHR12634:SF40 SIT4 YEAST -ASSOCIATING PROTEIN-RELATED FIERY MOUNTAIN, ISOFORM D enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG178341|UniProtKB=T1FD33 T1FD33 20206732 PTHR12868:SF0 NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179665|UniProtKB=T1FF02 T1FF02 20207401 PTHR24270:SF62 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED CD320 ANTIGEN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG79878|UniProtKB=T1G3U8 T1G3U8 20215746 PTHR10159:SF533 DUAL SPECIFICITY PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE VHP-1 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG156566|UniProtKB=T1ELY3 T1ELY3 20197583 PTHR10615:SF219 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT5 protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 Alzheimer disease-presenilin pathway#P00004>Tip60#P00137;Alzheimer disease-amyloid secretase pathway#P00003>Tip60#P00093 HELRO|EnsemblGenome=HelroG162251|UniProtKB=T1ESF0 T1ESF0 20199500 PTHR11537:SF105 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG185947|UniProtKB=T1FNH0 T1FNH0 20210367 PTHR10259:SF11 THIOPURINE S-METHYLTRANSFERASE THIOPURINE S-METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG164763|UniProtKB=T1EVS3 T1EVS3 20200673 PTHR24330:SF19 HOMEOBOX PROTEIN BARH-LIKE ARC105_MED15 MEDIATOR SUBUNIT C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG67222|UniProtKB=T1FYY3 T1FYY3 20214031 PTHR13490:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN MS35 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG63831|UniProtKB=T1FXL0 T1FXL0 20213558 PTHR14593:SF5 WD REPEAT-CONTAINING PROTEIN 11 WD REPEAT-CONTAINING PROTEIN 11 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG189742|UniProtKB=T1FRB9 T1FRB9 20211366 PTHR10288:SF356 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178654|UniProtKB=T1FDI4 T1FDI4 20206883 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular developmental process#GO:0048869;system process#GO:0003008;developmental process#GO:0032502;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501 contractile muscle fiber#GO:0043292;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG178959|UniProtKB=T1FDY9 T1FDY9 20207038 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160015|UniProtKB=T1EPN8 T1EPN8 20198538 PTHR16021:SF28 MANSC DOMAIN CONTAINING PROTEIN 1 OXIDANT-INDUCED CELL-CYCLE ARREST PROTEIN 5 HELRO|EnsemblGenome=HelroG104522|UniProtKB=T1EDM0 T1EDM0 20194672 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of gene expression#GO:0010629;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG64364|UniProtKB=T1FXT5 T1FXT5 20213633 PTHR10827:SF106 RETICULOCALBIN CALCIUM-BINDING PROTEIN metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG84103|UniProtKB=T1G5E8 T1G5E8 20216295 PTHR22916:SF73 GLYCOSYLTRANSFERASE QUEUOSINE-TRNA GALACTOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;galactosyltransferase activity#GO:0008378;catalytic activity, acting on a tRNA#GO:0140101 macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;tRNA wobble base modification#GO:0002097;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG75054|UniProtKB=T1G1Z9 T1G1Z9 20215097 PTHR12867:SF6 GLYCOSYL TRANSFERASE-RELATED UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 transferase#PC00220 HELRO|EnsemblGenome=HelroG170389|UniProtKB=T1F2Z8 T1F2Z8 20203197 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149;protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289 transport#GO:0006810;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046;localization#GO:0051179;establishment of localization#GO:0051234;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular process#GO:0009987;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;regulation of cellular process#GO:0050794 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG160219|UniProtKB=T1EPZ8 T1EPZ8 20198648 PTHR44826:SF3 SPORE COAT PROTEIN SP85 SPORE COAT PROTEIN SP85 HELRO|EnsemblGenome=HelroG192026|UniProtKB=T1FTI5 T1FTI5 20212132 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068;transporter#PC00227;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG156658|UniProtKB=T1ELZ5 T1ELZ5 20197595 PTHR11530:SF11 D-AMINO ACID OXIDASE D-AMINO ACID OXIDASE 2, ISOFORM A oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidase#PC00175 HELRO|EnsemblGenome=HelroG105347|UniProtKB=T1EDT9 T1EDT9 20194741 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG189192|UniProtKB=T1FQR7 T1FQR7 20211164 PTHR24039:SF60 FIBRILLIN-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG109357|UniProtKB=T1EES7 T1EES7 20195079 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG68612|UniProtKB=T1FZH3 T1FZH3 20214221 PTHR11138:SF5 METHIONYL-TRNA FORMYLTRANSFERASE METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG150398|UniProtKB=T1EKF6 T1EKF6 20197056 PTHR44899:SF11 CAMK FAMILY PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG165248|UniProtKB=T1EWH8 T1EWH8 20200928 PTHR34491:SF156 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED AUGMIN COMPLEX SUBUNIT DGT5 HELRO|EnsemblGenome=HelroG189993|UniProtKB=T1FRK5 T1FRK5 20211452 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194 transferase#PC00220 HELRO|EnsemblGenome=HelroG191424|UniProtKB=T1FSZ1 T1FSZ1 20211938 PTHR34365:SF7 ENOLASE (DUF1399) GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG157901|UniProtKB=T1EMH6 T1EMH6 20197776 PTHR10631:SF14 N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173 tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162966|UniProtKB=T1ETG1 T1ETG1 20199861 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187232|UniProtKB=T1FP80 T1FP80 20210627 PTHR21257:SF59 DELTA(14)-STEROL REDUCTASE DELTA(14)-STEROL REDUCTASE TM7SF2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;primary metabolic process#GO:0044238;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle envelope#GO:0031967;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle inner membrane#GO:0019866;membrane#GO:0016020;nuclear membrane#GO:0031965;nuclear inner membrane#GO:0005637;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG172338|UniProtKB=T1F575 T1F575 20203974 PTHR13055:SF12 TUMOR ENDOTHELIAL MARKER 7 RELATED LETHAL (1) G0289, ISOFORM D HELRO|EnsemblGenome=HelroG83158|UniProtKB=T1G513 T1G513 20216161 PTHR10457:SF7 MEVALONATE KINASE/GALACTOKINASE GALACTOKINASE-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065;metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 Fructose galactose metabolism#P02744>Galactokinase#P02960 HELRO|EnsemblGenome=HelroG160337|UniProtKB=T1EQ41 T1EQ41 20198691 PTHR13891:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7 oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG179723|UniProtKB=T1FF28 T1FF28 20207427 PTHR45888:SF19 HL01030P-RELATED FHA DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 HELRO|EnsemblGenome=HelroG132793|UniProtKB=T1EHZ5 T1EHZ5 20196195 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG185060|UniProtKB=T1FMC2 T1FMC2 20209971 PTHR12832:SF11 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 LD23868P cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188628|UniProtKB=T1FQ70 T1FQ70 20210967 PTHR11157:SF69 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 monocarboxylic acid biosynthetic process#GO:0072330;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG168554|UniProtKB=T1F0Q1 T1F0Q1 20202401 PTHR33590:SF4 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184715|UniProtKB=T1FLU5 T1FLU5 20209794 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG162883|UniProtKB=T1ETB4 T1ETB4 20199814 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG187664|UniProtKB=T1FPB7 T1FPB7 20210664 PTHR22883:SF511 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 vesicle organization#GO:0016050;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;developmental process#GO:0032502;protein targeting to membrane#GO:0006612;developmental maturation#GO:0021700;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein targeting#GO:0006605;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194530|UniProtKB=T1FW57 T1FW57 20213053 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG115001|UniProtKB=T1EG58 T1EG58 20195560 PTHR10414:SF71 ETHANOLAMINEPHOSPHOTRANSFERASE FI05338P transferase#PC00220 HELRO|EnsemblGenome=HelroG65582|UniProtKB=T1FYA1 T1FYA1 20213799 PTHR13259:SF1 BLADDER CANCER 10 KD PROTEIN HOMOLOG APOPTOSIS INDUCING FACTOR BLCAP HELRO|EnsemblGenome=HelroG116539|UniProtKB=T1EGF8 T1EGF8 20195660 PTHR10534:SF2 PYRIDOXAL KINASE PYRIDOXAL KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 kinase#PC00137 Pyridoxal phosphate salvage pathway#P02770>Pyridoxamine kinase#P03122;Vitamin B6 metabolism#P02787>Pyridoxal kinase#P03244;Pyridoxal phosphate salvage pathway#P02770>Pyridoxal kinase#P03121 HELRO|EnsemblGenome=HelroG176841|UniProtKB=T1FAY4 T1FAY4 20205983 PTHR10545:SF29 DIAMINE N-ACETYLTRANSFERASE GH14572P-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080 transferase#PC00220;acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG131923|UniProtKB=T1EHW6 T1EHW6 20196166 PTHR46223:SF4 HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG132066|UniProtKB=T1EHX2 T1EHX2 20196172 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;tetrapyrrole binding#GO:0046906;binding#GO:0005488;steroid hydroxylase activity#GO:0008395 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to stimulus#GO:0050896;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG156892|UniProtKB=T1EM27 T1EM27 20197627 PTHR23089:SF55 HISTIDINE TRIAD HIT PROTEIN ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide metabolic process#GO:0009259;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG167863|UniProtKB=T1EZW4 T1EZW4 20202114 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 HELRO|EnsemblGenome=HelroG173604|UniProtKB=T1F710 T1F710 20204609 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE MGP4 catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG166199|UniProtKB=T1EXW3 T1EXW3 20201413 PTHR12844:SF42 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KSR PROTEIN CNK protein complex scaffold activity#GO:0140378;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;structural molecule activity#GO:0005198;MAP kinase scaffold activity#GO:0005078;signaling adaptor activity#GO:0035591 cell surface receptor signaling pathway#GO:0007166;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194408|UniProtKB=T1FW09 T1FW09 20213005 PTHR10824:SF4 ACYL-COENZYME A THIOESTERASE-RELATED BAAT_C DOMAIN-CONTAINING PROTEIN fatty acyl-CoA hydrolase activity#GO:0047617;deacylase activity#GO:0160215;catalytic activity#GO:0003824;acyl-CoA hydrolase activity#GO:0016289;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;oxoacid metabolic process#GO:0043436;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 esterase#PC00097 HELRO|EnsemblGenome=HelroG163720|UniProtKB=T1EUE2 T1EUE2 20200192 PTHR23166:SF5 FILAMIN/GPBP-INTERACTING PROTEIN CTTNBP2 N-TERMINAL-LIKE PROTEIN protein localization to cytoskeleton#GO:0044380;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;localization#GO:0051179 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG76519|UniProtKB=T1G2K9 T1G2K9 20215307 PTHR44899:SF7 CAMK FAMILY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE NEK4 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG89164|UniProtKB=T1G794 T1G794 20216941 PTHR24089:SF769 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SCAMC transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;transport#GO:0006810;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;localization#GO:0051179 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG116409|UniProtKB=T1EGE6 T1EGE6 20195648 PTHR11208:SF42 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG190147|UniProtKB=T1FRQ7 T1FRQ7 20211504 PTHR46715:SF2 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE FYVE-TYPE DOMAIN-CONTAINING PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772 pigmentation#GO:0043473;organelle assembly#GO:0070925;vacuole organization#GO:0007033;localization#GO:0051179;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;lipid metabolic process#GO:0006629;lytic vacuole organization#GO:0080171;transport#GO:0006810;phagocytosis#GO:0006909;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;organophosphate metabolic process#GO:0019637;membrane fusion#GO:0061025;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;membrane organization#GO:0061024;regulation of reactive oxygen species metabolic process#GO:2000377;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;phosphorus metabolic process#GO:0006793;glycerolipid metabolic process#GO:0046486;endocytosis#GO:0006897;melanosome organization#GO:0032438;metabolic process#GO:0008152;phagolysosome assembly#GO:0001845;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;cellular process#GO:0009987;lysosome organization#GO:0007040;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;organelle membrane fusion#GO:0090174;cellular pigmentation#GO:0033059;glycerophospholipid metabolic process#GO:0006650;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;phagocytic vesicle#GO:0045335;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG185812|UniProtKB=T1FNB8 T1FNB8 20210315 PTHR11227:SF17 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED AUTOPHAGY-RELATED 18A, ISOFORM E phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;macromolecule localization#GO:0033036;glycogen catabolic process#GO:0005980;macroautophagy#GO:0016236;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;macromolecule metabolic process#GO:0043170;pexophagy#GO:0000425;energy derivation by oxidation of organic compounds#GO:0015980;intracellular protein localization#GO:0008104;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;organelle assembly#GO:0070925;energy reserve metabolic process#GO:0006112;localization#GO:0051179;vacuole organization#GO:0007033 phagophore assembly site#GO:0000407;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162801|UniProtKB=T1ET64 T1ET64 20199764 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG66677|UniProtKB=T1FYN9 T1FYN9 20213937 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG115400|UniProtKB=T1EG79 T1EG79 20195581 PTHR10672:SF44 ADDUCIN PROTEIN HU-LI TAI SHAO protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG72376|UniProtKB=T1G0Z1 T1G0Z1 20214739 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167650|UniProtKB=T1EZM3 T1EZM3 20202023 PTHR24392:SF62 ZINC FINGER PROTEIN PROTEIN CHARLATAN-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG159484|UniProtKB=T1EP31 T1EP31 20198331 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;N-acetyltransferase activity#GO:0008080;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186 HELRO|EnsemblGenome=HelroG186276|UniProtKB=T1FNW5 T1FNW5 20210512 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG156168|UniProtKB=T1ELS1 T1ELS1 20197521 PTHR13829:SF2 SNRNP CORE PROTEIN FAMILY MEMBER U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 U6 snRNP#GO:0005688;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG170182|UniProtKB=T1F2R6 T1F2R6 20203115 PTHR13278:SF0 ZINC FINGER PROTEIN 830 ZINC FINGER PROTEIN 830 regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;mitotic DNA replication checkpoint signaling#GO:0033314;regulation of biological process#GO:0050789;negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cellular response to stimulus#GO:0051716;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;biological regulation#GO:0065007;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;mitotic G2/M transition checkpoint#GO:0044818 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG155141|UniProtKB=T1ELH2 T1ELH2 20197422 PTHR18860:SF176 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON binding#GO:0005488;protein binding#GO:0005515 biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624 HELRO|EnsemblGenome=HelroG188744|UniProtKB=T1FQB7 T1FQB7 20211014 PTHR12276:SF126 EPSIN/ENT-RELATED CLATHRIN INTERACTOR 1 clathrin binding#GO:0030276;binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933 cytoplasm#GO:0005737;plasma membrane#GO:0005886;vesicle coat#GO:0030120;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated vesicle#GO:0030136;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178093|UniProtKB=T1FCQ3 T1FCQ3 20206602 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188108|UniProtKB=T1FPN2 T1FPN2 20210779 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG87604|UniProtKB=T1G6S8 T1G6S8 20216775 PTHR11006:SF125 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 3 N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone modifying activity#GO:0140993;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76139|UniProtKB=T1G2F5 T1G2F5 20215253 PTHR47633:SF4 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72035|UniProtKB=T1G0U3 T1G0U3 20214691 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;cation binding#GO:0043169;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515;enzyme regulator activity#GO:0030234 positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;cellular response to stress#GO:0033554;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to starvation#GO:0042594;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;cellular response to nutrient levels#GO:0031669;regulation of carbohydrate metabolic process#GO:0006109;cellular response to starvation#GO:0009267;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG183467|UniProtKB=T1FJQ2 T1FJQ2 20209051 PTHR14155:SF263 RING FINGER DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ATL6 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG63042|UniProtKB=T1FXA1 T1FXA1 20213449 PTHR11157:SF126 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 4 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 oxoacid metabolic process#GO:0043436;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;monocarboxylic acid biosynthetic process#GO:0072330;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG70277|UniProtKB=T1G041 T1G041 20214439 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG83308|UniProtKB=T1G539 T1G539 20216187 PTHR23359:SF105 NUCLEOTIDE KINASE ADENYLATE KINASE 7 transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG194472|UniProtKB=T1FW34 T1FW34 20213030 PTHR14166:SF17 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO-GAP DOMAIN-CONTAINING PROTEIN enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG92300|UniProtKB=T1G8E0 T1G8E0 20217337 PTHR15302:SF0 E3 UBIQUITIN-PROTEIN LIGASE RNF103 E3 UBIQUITIN-PROTEIN LIGASE RNF103 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG63358|UniProtKB=T1FXE8 T1FXE8 20213496 PTHR12749:SF0 EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1 DNA EXCISION REPAIR PROTEIN ERCC-1 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684 mitotic recombination#GO:0006312;cellular response to stress#GO:0033554;response to abiotic stimulus#GO:0009628;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular response to environmental stimulus#GO:0104004;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to radiation#GO:0071478;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;response to UV#GO:0009411;cellular response to abiotic stimulus#GO:0071214;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289 intracellular organelle#GO:0043229;nucleotide-excision repair complex#GO:0000109;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG192431|UniProtKB=T1FTY5 T1FTY5 20212282 PTHR10983:SF2 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG69392|UniProtKB=T1FZU6 T1FZU6 20214344 PTHR10013:SF7 GENERAL VESICULAR TRANSPORT FACTOR P115 GENERAL VESICULAR TRANSPORT FACTOR P115 cellular localization#GO:0051641;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;membrane organization#GO:0061024;cellular component organization#GO:0016043;membrane fusion#GO:0061025;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;Golgi stack#GO:0005795;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG175486|UniProtKB=T1F9B2 T1F9B2 20205411 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG164111|UniProtKB=T1EUY1 T1EUY1 20200381 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189288|UniProtKB=T1FQX2 T1FQX2 20211219 PTHR19879:SF1 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;nuclear DNA-directed RNA polymerase complex#GO:0055029;chromosome#GO:0005694;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;peptidase complex#GO:1905368;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;acetyltransferase complex#GO:1902493;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;histone acetyltransferase complex#GO:0000123;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;chromatin#GO:0000785;SAGA complex#GO:0000124 HELRO|EnsemblGenome=HelroG166737|UniProtKB=T1EYG4 T1EYG4 20201614 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97056|UniProtKB=T1G9F2 T1G9F2 20217699 PTHR11699:SF211 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG194139|UniProtKB=T1FVR0 T1FVR0 20212906 PTHR13793:SF160 PHD FINGER PROTEINS PHD FINGER PROTEIN RHINOCEROS chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG163371|UniProtKB=T1ETY8 T1ETY8 20200038 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515;binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 secretion#GO:0046903;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;positive regulation of cellular process#GO:0048522;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular component organization#GO:0051128;regulation of synaptic vesicle exocytosis#GO:2000300;export from cell#GO:0140352;signaling#GO:0023052;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;vesicle-mediated transport in synapse#GO:0099003;positive regulation of vesicle fusion#GO:0031340;exocytosis#GO:0006887;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulated exocytosis#GO:0045055;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;cellular process#GO:0009987;positive regulation of transport#GO:0051050;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;synaptic vesicle exocytosis#GO:0016079 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle membrane#GO:0031090;plasma membrane#GO:0005886;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG188735|UniProtKB=T1FQB3 T1FQB3 20211010 PTHR23280:SF13 4.1 G PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MYLIP aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG178017|UniProtKB=T1FCM2 T1FCM2 20206571 PTHR33562:SF27 ATILLA, ISOFORM B-RELATED-RELATED FI02817P-RELATED HELRO|EnsemblGenome=HelroG164871|UniProtKB=T1EVW7 T1EVW7 20200717 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG86325|UniProtKB=T1G6A5 T1G6A5 20216602 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG169248|UniProtKB=T1F1M7 T1F1M7 20202727 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72163|UniProtKB=T1G0W6 T1G0W6 20214714 PTHR11537:SF105 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;metal ion transport#GO:0030001;action potential#GO:0001508;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG171410|UniProtKB=T1F489 T1F489 20203638 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG93760|UniProtKB=T1G8X6 T1G8X6 20217523 PTHR13812:SF24 KETIMINE REDUCTASE MU-CRYSTALLIN KETIMINE REDUCTASE MU-CRYSTALLIN binding#GO:0005488;hormone binding#GO:0042562 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG69441|UniProtKB=T1FZV4 T1FZV4 20214352 PTHR11599:SF10 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-3 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;proteasome complex#GO:0000502;nucleus#GO:0005634 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG178225|UniProtKB=T1FCY6 T1FCY6 20206685 PTHR12271:SF66 POLY A POLYMERASE CID PAP -RELATED GH05885P catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG188909|UniProtKB=T1FQG8 T1FQG8 20211065 PTHR14624:SF0 DFG10 PROTEIN POLYPRENAL REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycoprotein metabolic process#GO:0009100 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG160072|UniProtKB=T1EPQ9 T1EPQ9 20198559 PTHR11913:SF122 COFILIN-RELATED COFILIN_ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 actin filament depolymerization#GO:0030042;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;protein depolymerization#GO:0051261;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG65840|UniProtKB=T1FYD3 T1FYD3 20213831 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG188261|UniProtKB=T1FPT3 T1FPT3 20210830 PTHR23193:SF23 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR PORE COMPLEX PROTEIN NUP153 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104;structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;protein transport#GO:0015031;nucleobase-containing compound transport#GO:0015931;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634 transporter#PC00227 HELRO|EnsemblGenome=HelroG140303|UniProtKB=T1EJ05 T1EJ05 20196555 PTHR24031:SF54 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX10-RELATED primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191905|UniProtKB=T1FTE5 T1FTE5 20212092 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG194683|UniProtKB=T1FWB2 T1FWB2 20213108 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG186252|UniProtKB=T1FNV4 T1FNV4 20210501 PTHR11645:SF0 PYRROLINE-5-CARBOXYLATE REDUCTASE PYRROLINE-5-CARBOXYLATE REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 reductase#PC00198;metabolite interconversion enzyme#PC00262 Proline biosynthesis#P02768>Pyrroline-5-carboxylate reductase#P03113 HELRO|EnsemblGenome=HelroG92341|UniProtKB=T1G8E6 T1G8E6 20217343 PTHR23512:SF5 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 LYSOSOMAL DIPEPTIDE TRANSPORTER MFSD1 ISOFORM X1 HELRO|EnsemblGenome=HelroG175149|UniProtKB=T1F8X3 T1F8X3 20205272 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113708|UniProtKB=T1EFV5 T1EFV5 20195457 PTHR22957:SF681 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 3 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG166804|UniProtKB=T1EYJ8 T1EYJ8 20201648 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166252|UniProtKB=T1EXY0 T1EXY0 20201430 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;hormone binding#GO:0042562;binding#GO:0005488 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG80799|UniProtKB=T1G457 T1G457 20215855 PTHR21136:SF179 SNARE PROTEINS VESICLE-ASSOCIATED MEMBRANE PROTEIN 7 protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein binding#GO:0005515;SNAP receptor activity#GO:0005484 vesicle localization#GO:0051648;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;membrane organization#GO:0061024;cytoskeleton-dependent intracellular transport#GO:0030705;vacuolar transport#GO:0007034;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;phagocytosis#GO:0006909;vesicle cytoskeletal trafficking#GO:0099518;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;Golgi organization#GO:0007030;protein localization to plasma membrane#GO:0072659;vesicle fusion#GO:0006906;Golgi to plasma membrane transport#GO:0006893;catabolic process#GO:0009056;microtubule-based movement#GO:0007018;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;endosome to lysosome transport#GO:0008333;organelle localization#GO:0051640;localization#GO:0051179;secretion#GO:0046903;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;autophagy#GO:0006914;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;endomembrane system organization#GO:0010256;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane invagination#GO:0010324;Golgi vesicle transport#GO:0048193;metabolic process#GO:0008152;protein localization to cell periphery#GO:1990778;exocytosis#GO:0006887;microtubule-based process#GO:0007017;vesicle organization#GO:0016050;phagocytosis, engulfment#GO:0006911;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;export from cell#GO:0140352;Golgi to plasma membrane protein transport#GO:0043001;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;microtubule-based transport#GO:0099111;lysosomal transport#GO:0007041;secretion by cell#GO:0032940;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641 plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 membrane traffic protein#PC00150;SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG193378|UniProtKB=T1FUX7 T1FUX7 20212623 PTHR15398:SF4 BROMODOMAIN-CONTAINING PROTEIN 8 BROMODOMAIN-CONTAINING PROTEIN 8 HELRO|EnsemblGenome=HelroG193217|UniProtKB=T1FUR5 T1FUR5 20212561 PTHR11003:SF359 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194509|UniProtKB=T1FW49 T1FW49 20213045 PTHR21682:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 149 COILED-COIL DOMAIN-CONTAINING PROTEIN 149 HELRO|EnsemblGenome=HelroG189672|UniProtKB=T1FR89 T1FR89 20211336 PTHR13451:SF0 CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT MUS81 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097 double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;negative regulation of mitotic cell cycle#GO:0045930;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;organelle organization#GO:0006996;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;double-strand break repair#GO:0006302;negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;reciprocal homologous recombination#GO:0140527;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;reproductive process#GO:0022414;homologous recombination#GO:0035825;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;sexual reproduction#GO:0019953;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;intracellular signal transduction#GO:0035556;organelle fission#GO:0048285;cell communication#GO:0007154;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;resolution of meiotic recombination intermediates#GO:0000712;double-strand break repair via break-induced replication#GO:0000727;DNA integrity checkpoint signaling#GO:0031570;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;DNA damage checkpoint signaling#GO:0000077;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;mitotic cell cycle process#GO:1903047;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170 endonuclease complex#GO:1905348;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG162969|UniProtKB=T1ETG4 T1ETG4 20199864 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG88217|UniProtKB=T1G700 T1G700 20216847 PTHR16083:SF85 LEUCINE RICH REPEAT CONTAINING PROTEIN RH62264P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191048|UniProtKB=T1FSJ4 T1FSJ4 20211791 PTHR12121:SF105 CARBON CATABOLITE REPRESSOR PROTEIN 4 PROTEIN ANGEL RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nucleic acid binding#GO:0003676;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;mRNA 3'-UTR binding#GO:0003730;nuclease activity#GO:0004518;binding#GO:0005488;mRNA binding#GO:0003729;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;mitochondrial RNA 3'-end processing#GO:0000965;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;mitochondrial RNA processing#GO:0000963;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of mRNA metabolic process#GO:1903313;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124 intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG170481|UniProtKB=T1F340 T1F340 20203239 PTHR12080:SF48 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG87707|UniProtKB=T1G6U6 T1G6U6 20216793 PTHR23248:SF63 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;endomembrane system organization#GO:0010256;lipid localization#GO:0010876;plasma membrane organization#GO:0007009;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;plasma membrane phospholipid scrambling#GO:0017121 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG179070|UniProtKB=T1FE51 T1FE51 20207100 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170607|UniProtKB=T1F384 T1F384 20203283 PTHR19441:SF95 WAP four-disulfide core domain protein ANTISTASIN-LIKE DOMAIN-CONTAINING PROTEIN enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG175137|UniProtKB=T1F8W9 T1F8W9 20205268 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of neurogenesis#GO:0050767;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;pattern specification process#GO:0007389;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG175644|UniProtKB=T1F9G7 T1F9G7 20205466 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163986|UniProtKB=T1EUQ3 T1EUQ3 20200303 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG166825|UniProtKB=T1EYK9 T1EYK9 20201659 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG190559|UniProtKB=T1FS32 T1FS32 20211629 PTHR23113:SF249 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;signaling#GO:0023052;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;intracellular signal transduction#GO:0035556;multicellular organismal process#GO:0032501;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG179495|UniProtKB=T1FES9 T1FES9 20207328 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG71407|UniProtKB=T1G0K9 T1G0K9 20214607 PTHR22069:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN S18 RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226 membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG177066|UniProtKB=T1FB70 T1FB70 20206069 PTHR10283:SF136 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2-LIKE ISOFORM X1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG189956|UniProtKB=T1FRJ0 T1FRJ0 20211437 PTHR31525:SF1 HEME TRANSPORTER HRG1 HEME TRANSPORTER HRG1 tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;binding#GO:0005488 metal ion transport#GO:0030001;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;transition metal ion transport#GO:0000041;iron ion transport#GO:0006826;iron coordination entity transport#GO:1901678 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG175867|UniProtKB=T1F9S8 T1F9S8 20205577 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG65165|UniProtKB=T1FY40 T1FY40 20213738 PTHR22891:SF198 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;single-stranded RNA binding#GO:0003727;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518 post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185385|UniProtKB=T1FMR1 T1FMR1 20210110 PTHR10687:SF96 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG69628|UniProtKB=T1FZX5 T1FZX5 20214373 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular process#GO:0009987;signal transduction#GO:0007165;synaptic signaling#GO:0099536 dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG172681|UniProtKB=T1F5S1 T1F5S1 20204170 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85683|UniProtKB=T1G616 T1G616 20216513 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;metal ion transport#GO:0030001;regulation of cytosolic calcium ion concentration#GO:0051480;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG170245|UniProtKB=T1F2T8 T1F2T8 20203137 PTHR24031:SF301 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX18 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG73394|UniProtKB=T1G1D5 T1G1D5 20214883 PTHR10632:SF2 SULFIDE:QUINONE OXIDOREDUCTASE SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG169136|UniProtKB=T1F1G1 T1F1G1 20202661 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178669|UniProtKB=T1FDJ4 T1FDJ4 20206893 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG62989|UniProtKB=T1FX90 T1FX90 20213438 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88238|UniProtKB=T1G704 T1G704 20216851 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cilium movement#GO:0003341;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;catalytic complex#GO:1902494;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;microtubule associated complex#GO:0005875;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG67906|UniProtKB=T1FZ75 T1FZ75 20214123 PTHR15614:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intraciliary transport particle B#GO:0030992;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG105206|UniProtKB=T1EDR7 T1EDR7 20194719 PTHR10625:SF57 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096;deacylase activity#GO:0160215;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;regulation of macromolecule biosynthetic process#GO:0010556;cellular component organization#GO:0016043;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG130955|UniProtKB=T1EHU8 T1EHU8 20196148 PTHR45709:SF6 LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED LARGE SUBUNIT GTPASE 1 HOMOLOG ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;transport#GO:0006810;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;ribonucleoprotein complex biogenesis#GO:0022613;establishment of organelle localization#GO:0051656;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;ribosome biogenesis#GO:0042254;organelle localization#GO:0051640;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG156778|UniProtKB=T1EM09 T1EM09 20197609 PTHR24078:SF586 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 5 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG159138|UniProtKB=T1ENN1 T1ENN1 20198181 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG93038|UniProtKB=T1G8R6 T1G8R6 20217463 PTHR10064:SF38 60S RIBOSOMAL PROTEIN L22 LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG158018|UniProtKB=T1EMI8 T1EMI8 20197788 PTHR11528:SF34 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN 83 ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP binding#GO:0005524;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of protein stability#GO:0031647;response to stress#GO:0006950;response to heat#GO:0009408;cellular response to heat#GO:0034605;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;biological regulation#GO:0065007;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein stabilization#GO:0050821;macromolecule metabolic process#GO:0043170 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622 Hsp90 family chaperone#PC00028;chaperone#PC00072 HELRO|EnsemblGenome=HelroG173912|UniProtKB=T1F7D2 T1F7D2 20204731 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111136|UniProtKB=T1EF86 T1EF86 20195238 PTHR12603:SF0 CCR4-NOT TRANSCRIPTION COMPLEX RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096 positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;protein catabolic process#GO:0030163;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of RNA stability#GO:0043487;protein metabolic process#GO:0019538;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;CCR4-NOT complex#GO:0030014 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77216|UniProtKB=T1G2U5 T1G2U5 20215393 PTHR12247:SF104 POLYCOMB GROUP PROTEIN POLYCOMB PROTEIN SFMBT protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG107917|UniProtKB=T1EED8 T1EED8 20194940 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HELRO|EnsemblGenome=HelroG111248|UniProtKB=T1EF98 T1EF98 20195250 PTHR11630:SF47 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR REC nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG166388|UniProtKB=T1EY29 T1EY29 20201479 PTHR11480:SF104 SAPOSIN-RELATED SAPOSIN B-TYPE DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194286|UniProtKB=T1FVW4 T1FVW4 20212960 PTHR24073:SF352 DRAB5-RELATED RAS-RELATED PROTEIN RAB6 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 intra-Golgi vesicle-mediated transport#GO:0006891;cytosolic transport#GO:0016482;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;intracellular protein transport#GO:0006886;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG183966|UniProtKB=T1FKD3 T1FKD3 20209282 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG164153|UniProtKB=T1EV04 T1EV04 20200404 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64950|UniProtKB=T1FY19 T1FY19 20213717 PTHR18916:SF97 DYNACTIN 1-RELATED MICROTUBULE-BINDING TUBULIN-FOLDING COFACTOR B protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;microtubule end#GO:1990752;cell cortex#GO:0005938;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cell periphery#GO:0071944 chaperone#PC00072 HELRO|EnsemblGenome=HelroG157417|UniProtKB=T1EMB2 T1EMB2 20197712 PTHR11655:SF16 60S/50S RIBOSOMAL PROTEIN L6/L9 LARGE RIBOSOMAL SUBUNIT PROTEIN UL6 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG122766|UniProtKB=T1EGV7 T1EGV7 20195807 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of cell cycle G2/M phase transition#GO:1902749;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G2/M phase transition#GO:0044839;regulation of reproductive process#GO:2000241;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell cycle#GO:0051726;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G2/M transition of mitotic cell cycle#GO:0010389 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167313|UniProtKB=T1EZ91 T1EZ91 20201891 PTHR25462:SF300 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-like protein ligase activity#GO:0061659 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG89299|UniProtKB=T1G7B8 T1G7B8 20216965 PTHR11475:SF147 OXIDASE/PEROXIDASE PEROXIDASIN peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peroxidase#PC00180;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174791|UniProtKB=T1F8H2 T1F8H2 20205121 PTHR36168:SF1 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE AAA PROTEIN C-TERMINAL WINGED HELIX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166700|UniProtKB=T1EYE1 T1EYE1 20201591 PTHR22730:SF1 PROMININ PROM PROTEIN PROMININ-LIKE PROTEIN plasma membrane bounded cell projection organization#GO:0120036;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030;cellular process#GO:0009987;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;vesicle#GO:0031982;microvillus#GO:0005902;actin-based cell projection#GO:0098858;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;extracellular region#GO:0005576;plasma membrane region#GO:0098590;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;apical part of cell#GO:0045177 HELRO|EnsemblGenome=HelroG113050|UniProtKB=T1EFP9 T1EFP9 20195401 PTHR22847:SF745 WD40 REPEAT PROTEIN F-BOX_WD REPEAT-CONTAINING PROTEIN 7 regulation of mitotic nuclear division#GO:0007088;regulation of nuclear division#GO:0051783;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of mitotic cell cycle#GO:0007346;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 Notch signaling pathway#P00045>Sel 10#P01102 HELRO|EnsemblGenome=HelroG164641|UniProtKB=T1EVN8 T1EVN8 20200638 PTHR15151:SF24 PROTEIN EIGER TUMOR NECROSIS FACTOR FAMILY MEMBER EIGER signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG163885|UniProtKB=T1EUK9 T1EUK9 20200259 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165585|UniProtKB=T1EX13 T1EX13 20201113 PTHR46190:SF1 SI:CH211-201H21.5-RELATED SI:CH211-201H21.5 HELRO|EnsemblGenome=HelroG74374|UniProtKB=T1G1Q3 T1G1Q3 20215001 PTHR12052:SF5 THIOREDOXIN-LIKE PROTEN 4A, 4B THIOREDOXIN-LIKE PROTEIN 4A nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG81951|UniProtKB=T1G4K9 T1G4K9 20216007 PTHR11764:SF94 TERPENE CYCLASE/MUTASE FAMILY MEMBER LANOSTEROL SYNTHASE intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;secondary alcohol biosynthetic process#GO:1902653;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229 lyase#PC00144;cyclase#PC00079 Cholesterol biosynthesis#P00014>Anosterol synthase#P00497 HELRO|EnsemblGenome=HelroG169912|UniProtKB=T1F2F8 T1F2F8 20203008 PTHR22776:SF102 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN RH30783P signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165965|UniProtKB=T1EXI4 T1EXI4 20201284 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161270|UniProtKB=T1ER99 T1ER99 20199099 PTHR15073:SF19 MICROTUBULE-ASSOCIATED PROTEIN ENSCONSIN, ISOFORM F organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule-based process#GO:0032886;microtubule bundle formation#GO:0001578;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG81881|UniProtKB=T1G4K2 T1G4K2 20216000 PTHR24248:SF209 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 5A ISOFORM X1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG102728|UniProtKB=T1EDB2 T1EDB2 20194564 PTHR19288:SF44 4-NITROPHENYLPHOSPHATASE-RELATED PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on acid anhydrides#GO:0016817;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG177522|UniProtKB=T1FBU3 T1FBU3 20206292 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG89337|UniProtKB=T1G7C3 T1G7C3 20216970 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE calcium/calmodulin-dependent protein kinase activity#GO:0004683;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG192743|UniProtKB=T1FU92 T1FU92 20212388 PTHR11958:SF99 SODIUM/DICARBOXYLATE SYMPORTER-RELATED EXCITATORY AMINO ACID TRANSPORTER dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;acidic amino acid transmembrane transporter activity#GO:0015172;sodium ion transmembrane transporter activity#GO:0015081;L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;sodium:dicarboxylate symporter activity#GO:0017153;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;L-glutamate transmembrane transport#GO:0015813;dicarboxylic acid transport#GO:0006835;carboxylic acid transport#GO:0046942;acidic amino acid transport#GO:0015800;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;carboxylic acid transmembrane transport#GO:1905039;L-glutamate import#GO:0051938;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036;Ionotropic glutamate receptor pathway#P00037>EAAT#P01011 HELRO|EnsemblGenome=HelroG182996|UniProtKB=T1FJ26 T1FJ26 20208825 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG103014|UniProtKB=T1EDD8 T1EDD8 20194590 PTHR23511:SF34 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2B ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG65590|UniProtKB=T1FYA4 T1FYA4 20213802 PTHR15104:SF0 DIHYDROPTERIDINE REDUCTASE DIHYDROPTERIDINE REDUCTASE oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG171551|UniProtKB=T1F4E5 T1F4E5 20203694 PTHR23220:SF133 INTEGRIN ALPHA INTEGRIN ALPHA-PS2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589 protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG183559|UniProtKB=T1FJU6 T1FJU6 20209095 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG175172|UniProtKB=T1F8Y7 T1F8Y7 20205286 PTHR22738:SF10 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110575|UniProtKB=T1EF33 T1EF33 20195185 PTHR47958:SF24 ATP-DEPENDENT RNA HELICASE DBP3 NUCLEOLAR RNA HELICASE 2-RELATED mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG173394|UniProtKB=T1F6R9 T1F6R9 20204518 PTHR21037:SF3 39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG105974|UniProtKB=T1EDY9 T1EDY9 20194791 PTHR47958:SF216 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG166051|UniProtKB=T1EXM9 T1EXM9 20201329 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175735|UniProtKB=T1F9L6 T1F9L6 20205515 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190726|UniProtKB=T1FS88 T1FS88 20211685 PTHR11101:SF97 PHOSPHATE TRANSPORTER PHOSPHATE TRANSPORTER solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;phosphate transmembrane transporter activity#GO:0005315;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 inorganic anion transport#GO:0015698;phosphate ion transport#GO:0006817;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG174005|UniProtKB=T1F7G9 T1F7G9 20204768 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG176357|UniProtKB=T1FAF8 T1FAF8 20205807 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG113295|UniProtKB=T1EFR5 T1EFR5 20195417 PTHR13848:SF56 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 5 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69505|UniProtKB=T1FZW1 T1FZW1 20214359 PTHR13152:SF0 TFIIH, POLYPEPTIDE 4 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4 transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896 nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transcription factor TFIIH core complex#GO:0000439;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIH complex#P00664;Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392 HELRO|EnsemblGenome=HelroG179184|UniProtKB=T1FEB5 T1FEB5 20207164 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66618|UniProtKB=T1FYN1 T1FYN1 20213929 PTHR12247:SF129 POLYCOMB GROUP PROTEIN SOP-2-RELATED PROTEIN 3 binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682;protein binding#GO:0005515 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG167982|UniProtKB=T1F013 T1F013 20202163 PTHR23319:SF4 GRAM DOMAIN CONTAINING 1B, ISOFORM E AT22714P-RELATED binding#GO:0005488;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;sterol binding#GO:0032934;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;sterol transfer activity#GO:0120015;transporter activity#GO:0005215;steroid binding#GO:0005496 organic hydroxy compound transport#GO:0015850;sterol transport#GO:0015918;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907;lipid localization#GO:0010876;intracellular sterol transport#GO:0032366;lipid transport#GO:0006869;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036 membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;organelle membrane contact site#GO:0044232;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165154|UniProtKB=T1EWC4 T1EWC4 20200874 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG177110|UniProtKB=T1FB86 T1FB86 20206085 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG92435|UniProtKB=T1G8G2 T1G8G2 20217359 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG176818|UniProtKB=T1FAX9 T1FAX9 20205978 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 amino acid transport#GO:0006865;cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG64770|UniProtKB=T1FXY9 T1FXY9 20213687 PTHR11537:SF294 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811 cation channel complex#GO:0034703;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;neuron projection#GO:0043005;presynapse#GO:0098793;cell leading edge#GO:0031252;protein-containing complex#GO:0032991;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;cell projection membrane#GO:0031253;cell body#GO:0044297;postsynapse#GO:0098794;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;voltage-gated potassium channel complex#GO:0008076;neuron projection membrane#GO:0032589;axon terminus#GO:0043679;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG171190|UniProtKB=T1F3X0 T1F3X0 20203519 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;molecular transducer activity#GO:0060089;hormone binding#GO:0042562;binding#GO:0005488 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169888|UniProtKB=T1F2E7 T1F2E7 20202997 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to stimulus#GO:0050896;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stress#GO:0006950 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG176568|UniProtKB=T1FAN7 T1FAN7 20205886 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG178948|UniProtKB=T1FDY0 T1FDY0 20207029 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194088|UniProtKB=T1FVN6 T1FVN6 20212882 PTHR12436:SF38 80 KDA MCM3-ASSOCIATED PROTEIN SAC3 DOMAIN-CONTAINING PROTEIN 1 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;gene expression#GO:0010467;chromosome segregation#GO:0007059;metabolic process#GO:0008152;microtubule organizing center organization#GO:0031023;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;spindle organization#GO:0007051;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;cell cycle#GO:0007049;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleocytoplasmic transport#GO:0006913;organelle assembly#GO:0070925;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;nucleic acid transport#GO:0050657 transcription export complex 2#GO:0070390;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73049|UniProtKB=T1G192 T1G192 20214840 PTHR10615:SF217 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE transcription regulator activity#GO:0140110;binding#GO:0005488;acetyltransferase activity#GO:0016407;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;N-acetyltransferase activity#GO:0008080;chromatin binding#GO:0003682;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;histone acetyltransferase activity#GO:0004402;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG81043|UniProtKB=T1G482 T1G482 20215880 PTHR12859:SF0 PRA1 PROTEIN PRA1 FAMILY PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG173246|UniProtKB=T1F6L5 T1F6L5 20204464 PTHR22629:SF0 ARP2/3 COMPLEX 20 KD SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 organelle organization#GO:0006996;cellular component organization#GO:0016043;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG164414|UniProtKB=T1EVE3 T1EVE3 20200543 PTHR24324:SF5 HOMEOBOX PROTEIN HHEX HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG168207|UniProtKB=T1F0B2 T1F0B2 20202262 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound metabolic process#GO:0006139;RNA catabolic process#GO:0006401;mitochondrial DNA metabolic process#GO:0032042;DNA-templated DNA replication#GO:0006261;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;catabolic process#GO:0009056 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG192651|UniProtKB=T1FU57 T1FU57 20212353 PTHR31434:SF2 S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM HELRO|EnsemblGenome=HelroG102639|UniProtKB=T1EDA7 T1EDA7 20194559 PTHR22763:SF196 RING ZINC FINGER PROTEIN E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173287|UniProtKB=T1F6N0 T1F6N0 20204479 PTHR15654:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 263 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ciliary plasm#GO:0097014;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG107767|UniProtKB=T1EEC6 T1EEC6 20194928 PTHR11864:SF0 PRE-MRNA-PROCESSING PROTEIN PRP40 PRE-MRNA-PROCESSING FACTOR 40 HOMOLOG A binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2-type prespliceosome#GO:0071004;spliceosomal complex#GO:0005681;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG171175|UniProtKB=T1F3W4 T1F3W4 20203513 PTHR39069:SF11 ECDYSONE-INDUCIBLE GENE E1, ISOFORM A EB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189235|UniProtKB=T1FQU5 T1FQU5 20211192 PTHR23320:SF142 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG155850|UniProtKB=T1ELN4 T1ELN4 20197484 PTHR10048:SF111 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE AGE-1 phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cell migration#GO:0016477;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;signal transduction#GO:0007165;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;phospholipid biosynthetic process#GO:0008654;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737 kinase#PC00137 Angiogenesis#P00005>PI3K#P00236;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;EGF receptor signaling pathway#P00018>PI3K#P00557;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Ras Pathway#P04393>PI3K#P04567;p53 pathway feedback loops 2#P04398>PI3K#P04661;FGF signaling pathway#P00021>PI3K#P00640;Integrin signalling pathway#P00034>PI3K#P00936;VEGF signaling pathway#P00056>PI3K#P01413;Axon guidance mediated by netrin#P00009>PI3K#P00363 HELRO|EnsemblGenome=HelroG182831|UniProtKB=T1FIT8 T1FIT8 20208737 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111907|UniProtKB=T1EFF7 T1EFF7 20195309 PTHR33562:SF2 ATILLA, ISOFORM B-RELATED-RELATED GEO05126P1 HELRO|EnsemblGenome=HelroG95115|UniProtKB=T1G946 T1G946 20217593 PTHR20920:SF5 RPE-SPONDIN VEXED, ISOFORM B HELRO|EnsemblGenome=HelroG180689|UniProtKB=T1FG62 T1FG62 20207811 PTHR31395:SF26 SHISA GEO05642P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166964|UniProtKB=T1EYT6 T1EYT6 20201736 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169542|UniProtKB=T1F226 T1F226 20202876 PTHR24026:SF51 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN cellular process#GO:0009987;neuron projection development#GO:0031175;axon development#GO:0061564;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;multicellular organismal process#GO:0032501;neuron differentiation#GO:0030182;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG166077|UniProtKB=T1EXP9 T1EXP9 20201349 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG SPT20 HOMOLOG, SAGA COMPLEX COMPONENT-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG190024|UniProtKB=T1FRL8 T1FRL8 20211465 PTHR12260:SF6 DAMAGE-CONTROL PHOSPHATASE ARMT1 DAMAGE-CONTROL PHOSPHATASE 1 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;response to stimulus#GO:0050896 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG89579|UniProtKB=T1G7E7 T1G7E7 20216994 PTHR31539:SF1 CENTROSOMAL PROTEIN OF 19K CEP19 CENTROSOMAL PROTEIN OF 19 KDA organelle assembly#GO:0070925;localization within membrane#GO:0051668;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;trans-Golgi to periciliary membrane compartment transport#GO:0097712;cilium organization#GO:0044782;post-Golgi vesicle-mediated transport#GO:0006892;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;Golgi to plasma membrane transport#GO:0006893;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;Golgi vesicle transport#GO:0048193;microtubule anchoring#GO:0034453;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;microtubule-based process#GO:0007017;vesicle-mediated transport to the plasma membrane#GO:0098876;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010 microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cilium#GO:0005929;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spindle pole#GO:0000922;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG88759|UniProtKB=T1G761 T1G761 20216908 PTHR13302:SF8 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization in cell#GO:0051649;retrograde transport, vesicle recycling within Golgi#GO:0000301 vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COG complex#GO:0017119;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG88048|UniProtKB=T1G6X9 T1G6X9 20216826 PTHR13048:SF0 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization in cell#GO:0051649;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;vesicle tethering complex#GO:0099023;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG67518|UniProtKB=T1FZ21 T1FZ21 20214069 PTHR46255:SF3 SHORT STATURE HOMEOBOX HOMEOBOX PROTEIN UNC-4 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG70743|UniProtKB=T1G0B6 T1G0B6 20214514 PTHR21274:SF0 MECKELIN MECKELIN cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987 plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;ciliary transition zone#GO:0035869 HELRO|EnsemblGenome=HelroG84056|UniProtKB=T1G5E1 T1G5E1 20216288 PTHR15825:SF0 UBIQUITIN-FOLD MODIFIER 1 UBIQUITIN-FOLD MODIFIER 1 macroautophagy#GO:0016236;response to stimulus#GO:0050896;catabolic process#GO:0009056;autophagy#GO:0006914;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;reticulophagy#GO:0061709;process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG189769|UniProtKB=T1FRC9 T1FRC9 20211376 PTHR13315:SF0 METALLO PHOSPHOESTERASE RELATED METALLOPHOSPHOESTERASE 1 esterase#PC00097;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178735|UniProtKB=T1FDN1 T1FDN1 20206930 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR TITIN transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG169480|UniProtKB=T1F1Z8 T1F1Z8 20202848 PTHR10877:SF194 POLYCYSTIN FAMILY MEMBER SPERM RECEPTOR FOR EGG JELLY metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085 response to stimulus#GO:0050896;response to external stimulus#GO:0009605;response to abiotic stimulus#GO:0009628;detection of mechanical stimulus#GO:0050982;detection of stimulus#GO:0051606;response to mechanical stimulus#GO:0009612 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133 HELRO|EnsemblGenome=HelroG184648|UniProtKB=T1FLN8 T1FLN8 20209737 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG179757|UniProtKB=T1FF45 T1FF45 20207444 PTHR23198:SF6 NUCLEOPORIN NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 telomere localization#GO:0034397;protein localization to organelle#GO:0033365;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;organelle localization#GO:0051640;nucleocytoplasmic transport#GO:0006913;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;telomere tethering at nuclear periphery#GO:0034398;cellular localization#GO:0051641;protein import into nucleus#GO:0006606;protein transport#GO:0015031;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;chromosome localization#GO:0050000;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967 transporter#PC00227 HELRO|EnsemblGenome=HelroG185741|UniProtKB=T1FN81 T1FN81 20210279 PTHR46283:SF2 E3 UBIQUITIN-PROTEIN LIGASE MARCH5 E3 UBIQUITIN-PROTEIN LIGASE MARCHF5 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 regulation of anatomical structure morphogenesis#GO:0022603;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;regulation of developmental process#GO:0050793;regulation of mitochondrial fission#GO:0090140;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;regulation of mitochondrion organization#GO:0010821;protein modification process#GO:0036211;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG155720|UniProtKB=T1ELL4 T1ELL4 20197464 PTHR16705:SF4 COMPLEXIN COMPLEXIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 regulation of signaling#GO:0023051;cellular localization#GO:0051641;secretion by cell#GO:0032940;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;export from cell#GO:0140352;regulated exocytosis#GO:0045055;vesicle-mediated transport in synapse#GO:0099003;regulation of localization#GO:0032879;exocytosis#GO:0006887;regulation of transport#GO:0051049;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;synapse#GO:0045202;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;axon#GO:0030424;intracellular anatomical structure#GO:0005622;neuron projection#GO:0043005;presynapse#GO:0098793;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;axon terminus#GO:0043679;cell junction#GO:0030054 HELRO|EnsemblGenome=HelroG165085|UniProtKB=T1EW98 T1EW98 20200848 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73864|UniProtKB=T1G1J6 T1G1J6 20214944 PTHR45957:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;metaphase/anaphase transition of cell cycle#GO:0044784;regulation of chromosome segregation#GO:0051983;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;cellular process#GO:0009987;protein ubiquitination#GO:0016567;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;mitotic cell cycle phase transition#GO:0044772;metaphase/anaphase transition of mitotic cell cycle#GO:0007091;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein K11-linked ubiquitination#GO:0070979;cell cycle#GO:0007049;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;mitotic cell cycle#GO:0000278;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231 Cell cycle#P00013>APC#P00481 HELRO|EnsemblGenome=HelroG161444|UniProtKB=T1ERH2 T1ERH2 20199172 PTHR13378:SF1 REGULATOR COMPLEX PROTEIN LAMTOR3 RAGULATOR COMPLEX PROTEIN LAMTOR3 cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of TORC1 signaling#GO:1904263;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;response to acid chemical#GO:0001101;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84610|UniProtKB=T1G5K8 T1G5K8 20216355 PTHR23426:SF65 FERREDOXIN/ADRENODOXIN ADRENODOXIN-LIKE PROTEIN 2, MITOCHONDRIAL electron transport chain#GO:0022900;metabolic process#GO:0008152;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FDX#P04607 HELRO|EnsemblGenome=HelroG178174|UniProtKB=T1FCW1 T1FCW1 20206660 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG146486|UniProtKB=T1EJS5 T1EJS5 20196825 PTHR23050:SF552 CALCIUM BINDING PROTEIN AT16150P-RELATED molecular function regulator activity#GO:0098772;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;cation binding#GO:0043169 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;T cell activation#P00053>Calmodulin#P01305;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG102505|UniProtKB=T1ED99 T1ED99 20194551 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;DNA-templated transcription elongation#GO:0006354 RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190906|UniProtKB=T1FSE7 T1FSE7 20211744 PTHR10670:SF0 DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A hydrolase activity#GO:0016787;DNA-directed DNA polymerase activity#GO:0003887;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;exonuclease activity#GO:0004527;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;transferase activity#GO:0016740;DNA exonuclease activity#GO:0004529 DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;cellular process#GO:0009987;response to stress#GO:0006950;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;epsilon DNA polymerase complex#GO:0008622;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG160080|UniProtKB=T1EPR2 T1EPR2 20198562 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG78519|UniProtKB=T1G3C5 T1G3C5 20215573 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159790|UniProtKB=T1EPE7 T1EPE7 20198447 PTHR23048:SF0 MYOSIN LIGHT CHAIN 1, 3 FI08416P-RELATED intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG164398|UniProtKB=T1EVD8 T1EVD8 20200538 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG78723|UniProtKB=T1G3F1 T1G3F1 20215599 PTHR12925:SF2 HIKESHI FAMILY MEMBER PROTEIN HIKESHI heat shock protein binding#GO:0031072;nucleocytoplasmic carrier activity#GO:0140142;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;molecular carrier activity#GO:0140104;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;nucleocytoplasmic transport#GO:0006913;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;protein localization to organelle#GO:0033365 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG134536|UniProtKB=T1EI52 T1EI52 20196252 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG76196|UniProtKB=T1G2G6 T1G2G6 20215264 PTHR24347:SF457 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;regulation of cellular process#GO:0050794;polysaccharide metabolic process#GO:0005976;response to stimulus#GO:0050896;signaling#GO:0023052;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;glycogen metabolic process#GO:0005977;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;energy reserve metabolic process#GO:0006112 protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG86803|UniProtKB=T1G6H0 T1G6H0 20216667 PTHR24049:SF22 CRUMBS FAMILY MEMBER DELTA-LIKE PROTEIN cell-cell adhesion#GO:0098609;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of bipolar cell polarity#GO:0061245;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG141072|UniProtKB=T1EJ24 T1EJ24 20196574 PTHR22807:SF4 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102 ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;positive regulation of protein metabolic process#GO:0051247;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA metabolic process#GO:0016070;methylation#GO:0032259;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;rRNA modification#GO:0000154;regulation of biological process#GO:0050789;ribonucleoprotein complex biogenesis#GO:0022613;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;regulation of protein metabolic process#GO:0051246;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;rRNA base methylation#GO:0070475;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;RNA processing#GO:0006396;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;positive regulation of biosynthetic process#GO:0009891;rRNA processing#GO:0006364;positive regulation of translation#GO:0045727;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190496|UniProtKB=T1FS15 T1FS15 20211612 PTHR10766:SF176 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;localization within membrane#GO:0051668 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG185272|UniProtKB=T1FML3 T1FML3 20210062 PTHR11599:SF13 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-4 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 nucleus#GO:0005634;proteasome complex#GO:0000502;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG74560|UniProtKB=T1G1S7 T1G1S7 20215025 PTHR10281:SF106 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED IP06960P-RELATED intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160520|UniProtKB=T1EQC7 T1EQC7 20198777 PTHR24351:SF110 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;TOR signaling#GO:0031929;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;TORC1 signaling#GO:0038202;intracellular signal transduction#GO:0035556 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;Interleukin signaling pathway#P00036>p90RSK#P00964;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG162052|UniProtKB=T1ES70 T1ES70 20199420 PTHR18952:SF283 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XB-RELATED metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG100238|UniProtKB=T1ECZ1 T1ECZ1 20194443 PTHR11588:SF540 TUBULIN TUBULIN GAMMA CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;nuclear division#GO:0000280;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;sister chromatid segregation#GO:0000819;microtubule nucleation#GO:0007020;microtubule polymerization#GO:0046785;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;microtubule polymerization or depolymerization#GO:0031109;mitotic sister chromatid segregation#GO:0000070;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;sexual reproduction#GO:0019953;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813 cytoskeletal protein#PC00085;tubulin#PC00228 HELRO|EnsemblGenome=HelroG190821|UniProtKB=T1FSB6 T1FSB6 20211713 PTHR13817:SF185 TITIN PROTEIN-TYROSINE-PHOSPHATASE structural protein#PC00211 HELRO|EnsemblGenome=HelroG164115|UniProtKB=T1EUY2 T1EUY2 20200382 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG110739|UniProtKB=T1EF49 T1EF49 20195201 PTHR11958:SF63 SODIUM/DICARBOXYLATE SYMPORTER-RELATED AMINO ACID TRANSPORTER amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;L-amino acid transmembrane transporter activity#GO:0015179;sodium ion transmembrane transporter activity#GO:0015081;acidic amino acid transmembrane transporter activity#GO:0015172;solute:monoatomic cation symporter activity#GO:0015294;L-glutamate transmembrane transporter activity#GO:0005313;dicarboxylic acid transmembrane transporter activity#GO:0005310;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;sodium:dicarboxylate symporter activity#GO:0017153;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 L-glutamate transmembrane transport#GO:0015813;dicarboxylic acid transport#GO:0006835;cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;carboxylic acid transmembrane transport#GO:1905039;L-alpha-amino acid transmembrane transport#GO:1902475;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;L-glutamate import#GO:0051938 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 Ionotropic glutamate receptor pathway#P00037>EAAT#P01011;Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036 HELRO|EnsemblGenome=HelroG161704|UniProtKB=T1ERT0 T1ERT0 20199280 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG63672|UniProtKB=T1FXI9 T1FXI9 20213537 PTHR16023:SF0 TAX1 BINDING PROTEIN-RELATED PROTEIN VAC14 HOMOLOG organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;vacuole#GO:0005773;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91961|UniProtKB=T1G8A9 T1G8A9 20217306 PTHR18952:SF283 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XB-RELATED dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG131581|UniProtKB=T1EHW1 T1EHW1 20196161 PTHR24058:SF112 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167491|UniProtKB=T1EZF3 T1EZF3 20201953 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175868|UniProtKB=T1F9S9 T1F9S9 20205578 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65928|UniProtKB=T1FYE4 T1FYE4 20213842 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267 cellular process#GO:0009987;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;action potential#GO:0001508;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG172663|UniProtKB=T1F5R4 T1F5R4 20204163 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG182832|UniProtKB=T1FIT9 T1FIT9 20208738 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG74685|UniProtKB=T1G1U1 T1G1U1 20215039 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG188931|UniProtKB=T1FQH8 T1FQH8 20211075 PTHR19879:SF1 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;acetyltransferase complex#GO:1902493;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;SAGA complex#GO:0000124;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;peptidase complex#GO:1905368;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG67463|UniProtKB=T1FZ12 T1FZ12 20214060 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG158373|UniProtKB=T1EMQ1 T1EMQ1 20197851 PTHR19325:SF567 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING SUSHI DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG183750|UniProtKB=T1FK51 T1FK51 20209200 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178934|UniProtKB=T1FDX3 T1FDX3 20207022 PTHR24260:SF149 AT07769P-RELATED AT07769P-RELATED HELRO|EnsemblGenome=HelroG80635|UniProtKB=T1G433 T1G433 20215831 PTHR10130:SF0 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signal sequence receptor activity#GO:0005048 peroxisome organization#GO:0007031;protein transport#GO:0015031;peroxisomal transport#GO:0043574;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;cellular component organization#GO:0016043;protein import into peroxisome matrix#GO:0016558;protein localization to organelle#GO:0033365;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;organelle organization#GO:0006996 peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;peroxisome#GO:0005777;cytosol#GO:0005829;microbody#GO:0042579;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG112326|UniProtKB=T1EFI7 T1EFI7 20195339 PTHR14604:SF4 WD40 REPEAT PF20 BETA-TRCP-LIKE ISOFORM X1 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 microtubule or microtubule-binding cytoskeletal protein#PC00157 Hedgehog signaling pathway#P00025>Slimb#P00683;Wnt signaling pathway#P00057>betaTrCP#P01454 HELRO|EnsemblGenome=HelroG125204|UniProtKB=T1EH49 T1EH49 20195899 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG185792|UniProtKB=T1FNA5 T1FNA5 20210302 PTHR11246:SF3 PRE-MRNA SPLICING FACTOR CROOKED NECK-LIKE PROTEIN 1 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185435|UniProtKB=T1FMT7 T1FMT7 20210136 PTHR13703:SF25 SMAD SMAD FAMILY MEMBER 2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;protein binding#GO:0005515;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;positive regulation of macromolecule metabolic process#GO:0010604;intracellular signaling cassette#GO:0141124;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;activin receptor signaling pathway#GO:0032924;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular response to growth factor stimulus#GO:0071363;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 ALP23B signaling pathway#P06209>SMOX#P06224;TGF-beta signaling pathway#P00052>RSmads#P01292;BMP/activin signaling pathway-drosophila#P06211>R-Smad#P06245;Activin beta signaling pathway#P06210>SMOX#P06236;MYO signaling pathway#P06215>SMOX#P06314 HELRO|EnsemblGenome=HelroG83714|UniProtKB=T1G595 T1G595 20216242 PTHR24031:SF89 RNA HELICASE ATP-DEPENDENT DNA HELICASE DDX31 ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG165185|UniProtKB=T1EWE5 T1EWE5 20200895 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87021|UniProtKB=T1G6K7 T1G6K7 20216704 PTHR22807:SF34 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173 rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;methylation#GO:0032259;rRNA base methylation#GO:0070475;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG188808|UniProtKB=T1FQD8 T1FQD8 20211035 PTHR14063:SF10 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of growth#GO:0040008;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;regulation of cell junction assembly#GO:1901888;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;regulation of synapse structure or activity#GO:0050803;vesicle localization#GO:0051648;regulation of synapse assembly#GO:0051963;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;transport#GO:0006810;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;establishment of organelle localization#GO:0051656;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component biogenesis#GO:0044087;regulation of synapse organization#GO:0050807;cellular localization#GO:0051641;secretion by cell#GO:0032940;regulation of biological quality#GO:0065008;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic vesicle localization#GO:0097479;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell junction#GO:0030054 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG162705|UniProtKB=T1ET12 T1ET12 20199712 PTHR12442:SF11 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 1 binding#GO:0005488;protein binding#GO:0005515 microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;organelle assembly#GO:0070925;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987 cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG94341|UniProtKB=T1G903 T1G903 20217550 PTHR11353:SF23 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT BETA protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;protein folding chaperone complex#GO:0101031;chaperonin-containing T-complex#GO:0005832;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG181666|UniProtKB=T1FH79 T1FH79 20208178 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN CC8L18.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG88556|UniProtKB=T1G738 T1G738 20216885 PTHR12411:SF1075 CYSTEINE PROTEASE FAMILY C1-RELATED COUNTING FACTOR ASSOCIATED PROTEIN D hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG187040|UniProtKB=T1FP59 T1FP59 20210606 PTHR13465:SF4 UPF0183 PROTEIN PHAF1 PROTEIN CG7083 establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;protein localization to cell periphery#GO:1990778;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167931|UniProtKB=T1EZZ4 T1EZZ4 20202144 PTHR44394:SF1 BETA-ALANINE-ACTIVATING ENZYME BETA-ALANINE-ACTIVATING ENZYME metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG88788|UniProtKB=T1G765 T1G765 20216912 PTHR22958:SF43 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1 phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 glycerophospholipid catabolic process#GO:0046475;organophosphate catabolic process#GO:0046434;glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158659|UniProtKB=T1EN36 T1EN36 20197986 PTHR18901:SF48 2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2 PSEUDOURIDINE-5'-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG64907|UniProtKB=T1FY10 T1FY10 20213708 PTHR12483:SF115 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915 copper ion transmembrane transport#GO:0035434;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;transition metal ion transport#GO:0000041 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG63747|UniProtKB=T1FXJ7 T1FXJ7 20213545 PTHR15454:SF56 NISCHARIN RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22 HOMOLOG-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193034|UniProtKB=T1FUJ7 T1FUJ7 20212493 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163001|UniProtKB=T1ETJ3 T1ETJ3 20199893 PTHR31598:SF1 IQ DOMAIN-CONTAINING PROTEIN D DYNEIN REGULATORY COMPLEX SUBUNIT 10 HELRO|EnsemblGenome=HelroG190914|UniProtKB=T1FSE9 T1FSE9 20211746 PTHR24214:SF38 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cytoskeleton organization#GO:0007010;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;anatomical structure development#GO:0048856 actomyosin#GO:0042641;cell-cell junction#GO:0005911;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;actin filament#GO:0005884;stress fiber#GO:0001725;cytoskeleton#GO:0005856;adherens junction#GO:0005912;cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG159451|UniProtKB=T1EP20 T1EP20 20198320 PTHR24068:SF132 UBIQUITIN-CONJUGATING ENZYME E2 NEDD8-CONJUGATING ENZYME UBCE2M ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG182655|UniProtKB=T1FIJ7 T1FIJ7 20208646 PTHR24082:SF506 NUCLEAR HORMONE RECEPTOR NR LBD DOMAIN-CONTAINING PROTEIN C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG162036|UniProtKB=T1ES63 T1ES63 20199413 PTHR44592:SF3 NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN RNA LIGASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190751|UniProtKB=T1FS95 T1FS95 20211692 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT AT04468P-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671 intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;potassium ion homeostasis#GO:0055075;localization#GO:0051179;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082 ATPase dependent transmembrane transport complex#GO:0098533;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG110263|UniProtKB=T1EF09 T1EF09 20195161 PTHR45994:SF1 FI21225P1 FI21225P1 binding#GO:0005488;heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879;protein binding#GO:0005515 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG62924|UniProtKB=T1FX78 T1FX78 20213426 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG122103|UniProtKB=T1EGT9 T1EGT9 20195789 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG78931|UniProtKB=T1G3H4 T1G3H4 20215622 PTHR44554:SF1 LRP2-BINDING PROTEIN LRP2-BINDING PROTEIN HELRO|EnsemblGenome=HelroG113547|UniProtKB=T1EFT4 T1EFT4 20195436 PTHR24247:SF267 5-HYDROXYTRYPTAMINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170076|UniProtKB=T1F2L8 T1F2L8 20203067 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG190373|UniProtKB=T1FRX9 T1FRX9 20211576 PTHR13014:SF3 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN LARGE RIBOSOMAL SUBUNIT PROTEIN ML65 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG64289|UniProtKB=T1FXS3 T1FXS3 20213621 PTHR12303:SF14 CARNOSINE N-METHYLTRANSFERASE PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE CARNMT1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG99127|UniProtKB=T1G9R1 T1G9R1 20217807 PTHR14374:SF0 FOIE GRAS TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 HELRO|EnsemblGenome=HelroG182988|UniProtKB=T1FJ21 T1FJ21 20208820 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG176402|UniProtKB=T1FAH5 T1FAH5 20205824 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176619|UniProtKB=T1FAQ7 T1FAQ7 20205906 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993 HELRO|EnsemblGenome=HelroG116040|UniProtKB=T1EGC6 T1EGC6 20195628 PTHR11113:SF14 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;deacylase activity#GO:0160215;deacetylase activity#GO:0019213;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;amino sugar catabolic process#GO:0046348;amino sugar metabolic process#GO:0006040;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;metabolic process#GO:0008152 deacetylase#PC00087;metabolite interconversion enzyme#PC00262 N-acetylglucosamine metabolism#P02756>N-acetylglucosamine-6-phosphate deacetylase#P03036 HELRO|EnsemblGenome=HelroG177413|UniProtKB=T1FBN1 T1FBN1 20206230 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176145|UniProtKB=T1FA73 T1FA73 20205722 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153369|UniProtKB=T1EL53 T1EL53 20197303 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG188210|UniProtKB=T1FPS2 T1FPS2 20210819 PTHR11304:SF29 EPHRIN EPHRIN signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG65256|UniProtKB=T1FY51 T1FY51 20213749 PTHR11938:SF152 FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE GLUTAMATE SYNTHASE [NADH] oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;chemical homeostasis#GO:0048878;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;response to nutrient levels#GO:0031667;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;homeostatic process#GO:0042592;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159850|UniProtKB=T1EPH0 T1EPH0 20198470 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171311|UniProtKB=T1F431 T1F431 20203580 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG193435|UniProtKB=T1FUZ4 T1FUZ4 20212640 PTHR13165:SF0 ARSENITE-RESISTANCE PROTEIN 2 SERRATE RNA EFFECTOR MOLECULE HOMOLOG RNA binding#GO:0003723;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary miRNA processing#GO:0031053;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG172081|UniProtKB=T1F504 T1F504 20203903 PTHR24270:SF69 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG109389|UniProtKB=T1EET1 T1EET1 20195083 PTHR12100:SF0 SEC10 EXOCYST COMPLEX COMPONENT 5 vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810 vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;exocyst#GO:0000145;cytoplasm#GO:0005737 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG173132|UniProtKB=T1F6F2 T1F6F2 20204401 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG167592|UniProtKB=T1EZJ0 T1EZJ0 20201990 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG185398|UniProtKB=T1FMR6 T1FMR6 20210115 PTHR15592:SF18 MATRIN 3/NUCLEAR PROTEIN 220-RELATED SMOOTH, ISOFORM T RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG103352|UniProtKB=T1EDF7 T1EDF7 20194609 PTHR11815:SF1 SUCCINYL-COA SYNTHETASE BETA CHAIN SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 cellular respiration#GO:0045333;aerobic respiration#GO:0009060;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;energy derivation by oxidation of organic compounds#GO:0015980;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;tricarboxylic acid cycle#GO:0006099;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 ligase#PC00142 HELRO|EnsemblGenome=HelroG189052|UniProtKB=T1FQL4 T1FQL4 20211111 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;positive regulation of cell population proliferation#GO:0008284;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;nervous system development#GO:0007399;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;system development#GO:0048731;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG82119|UniProtKB=T1G4N1 T1G4N1 20216029 PTHR46167:SF1 N-LYSINE METHYLTRANSFERASE KMT5A N-LYSINE METHYLTRANSFERASE KMT5A lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;chromosome organization#GO:0051276;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73751|UniProtKB=T1G1I0 T1G1I0 20214928 PTHR13085:SF0 MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT SIGNAL PEPTIDASE COMPLEX SUBUNIT 2 localization#GO:0051179;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein targeting#GO:0006605;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;protein targeting to ER#GO:0045047;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;establishment of protein localization to endoplasmic reticulum#GO:0072599;biosynthetic process#GO:0009058 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endopeptidase complex#GO:1905369;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;cytoplasm#GO:0005737;peptidase complex#GO:1905368;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 protease#PC00190 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG115063|UniProtKB=T1EG61 T1EG61 20195563 PTHR48067:SF1 GPI-ANCHOR TRANSAMIDASE GPI-ANCHOR TRANSAMIDASE transferase activity#GO:0016740;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787 GPI anchored protein biosynthesis#GO:0180046;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;peptidase complex#GO:1905368;caspase complex#GO:0008303;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endopeptidase complex#GO:1905369;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG184821|UniProtKB=T1FM18 T1FM18 20209867 PTHR10218:SF365 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA Q SUBUNIT-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234 heterotrimeric G-protein#PC00117;G-protein#PC00020 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Endothelin signaling pathway#P00019>Gq#P00586;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Wnt signaling pathway#P00057>Galpha#P01451;PI3 kinase pathway#P00048>Galpha#P01199;Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057 HELRO|EnsemblGenome=HelroG69675|UniProtKB=T1FZX9 T1FZX9 20214377 PTHR13023:SF3 APYRASE SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;membrane#GO:0016020 nucleotide phosphatase#PC00173;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183573|UniProtKB=T1FJV1 T1FJV1 20209100 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84013|UniProtKB=T1G5D2 T1G5D2 20216279 PTHR13479:SF40 30S RIBOSOMAL PROTEIN S18 SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG194214|UniProtKB=T1FVT4 T1FVT4 20212930 PTHR11595:SF92 EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER ELONGATION FACTOR 1-BETA guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG176707|UniProtKB=T1FAT1 T1FAT1 20205930 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64842|UniProtKB=T1FY01 T1FY01 20213699 PTHR19338:SF107 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM13 mitochondrion organization#GO:0007005;protein insertion into mitochondrial inner membrane#GO:0045039;mitochondrial protein import pathway#GO:7770058;membrane organization#GO:0061024;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular transport#GO:0046907;transport#GO:0006810;mitochondrial transport#GO:0006839;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641 membrane-enclosed lumen#GO:0031974;mitochondrial envelope#GO:0005740;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;mitochondrial intermembrane space#GO:0005758;organelle envelope#GO:0031967;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG82715|UniProtKB=T1G4V7 T1G4V7 20216105 PTHR10695:SF62 DEPHOSPHO-COA KINASE-RELATED CYTIDYLTRANSFERASE-LIKE DOMAIN-CONTAINING PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178071|UniProtKB=T1FCP4 T1FCP4 20206593 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178849|UniProtKB=T1FDT6 T1FDT6 20206985 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 leading edge membrane#GO:0031256;neuron projection membrane#GO:0032589;cell projection membrane#GO:0031253;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG194303|UniProtKB=T1FVW7 T1FVW7 20212963 PTHR21646:SF24 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG190486|UniProtKB=T1FS13 T1FS13 20211610 PTHR23104:SF17 MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG111102|UniProtKB=T1EF82 T1EF82 20195234 PTHR15276:SF0 H4 D10S170 PROTEIN-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG180285|UniProtKB=T1FFP3 T1FFP3 20207642 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG103283|UniProtKB=T1EDF3 T1EDF3 20194605 PTHR22948:SF85 TUDOR DOMAIN CONTAINING PROTEIN RE73736P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG85565|UniProtKB=T1G5Z5 T1G5Z5 20216492 PTHR10328:SF3 PROTEIN MAX MYC-ASSOCIATED FACTOR X PROTEIN MAX DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 Oxidative stress response#P00046>Max#P01133 HELRO|EnsemblGenome=HelroG74817|UniProtKB=T1G1W1 T1G1W1 20215059 PTHR10192:SF33 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN GEPHYRIN catalytic activity#GO:0003824;transferase activity#GO:0016740 receptor clustering#GO:0043113;localization within membrane#GO:0051668;synapse organization#GO:0050808;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;cellular localization#GO:0051641;localization#GO:0051179;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;metabolic process#GO:0008152;neuromuscular junction development#GO:0007528;intracellular protein localization#GO:0008104;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;membrane organization#GO:0061024;biosynthetic process#GO:0009058 dendritic tree#GO:0097447;dendrite#GO:0030425;postsynaptic membrane#GO:0045211;intracellular anatomical structure#GO:0005622;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;synaptic membrane#GO:0097060;cell junction#GO:0030054;neuron projection#GO:0043005;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cytoplasm#GO:0005737;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590 HELRO|EnsemblGenome=HelroG176931|UniProtKB=T1FB20 T1FB20 20206019 PTHR10027:SF41 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN SLOWPOKE 2, ISOFORM D transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;outward rectifier potassium channel activity#GO:0015271;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG168710|UniProtKB=T1F0V9 T1F0V9 20202459 PTHR22419:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 172 COILED-COIL DOMAIN-CONTAINING PROTEIN 172 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG147055|UniProtKB=T1EJW5 T1EJW5 20196865 PTHR10071:SF340 TRANSCRIPTION FACTOR GATA FAMILY MEMBER FI19405P1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cell fate commitment#GO:0045165;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG82550|UniProtKB=T1G4T8 T1G4T8 20216086 PTHR45897:SF4 HIGH-AFFINITY CHOLINE TRANSPORTER 1 HIGH-AFFINITY CHOLINE TRANSPORTER 1 solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>CHT1#P01072;Nicotinic acetylcholine receptor signaling pathway#P00044>CHT1#P01098;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG191687|UniProtKB=T1FT75 T1FT75 20212022 PTHR24056:SF400 CELL DIVISION PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG174181|UniProtKB=T1F7R1 T1F7R1 20204860 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG181485|UniProtKB=T1FH19 T1FH19 20208118 PTHR12363:SF33 TRANSPORTIN 3 AND IMPORTIN 13 IMPORTIN-13 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG78720|UniProtKB=T1G3F0 T1G3F0 20215598 PTHR12192:SF26 CATION TRANSPORT PROTEIN CHAC-RELATED GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1 catalytic activity#GO:0003824;lyase activity#GO:0016829 sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056;cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193902|UniProtKB=T1FVG7 T1FVG7 20212813 PTHR11633:SF1 PLATELET-DERIVED GROWTH FACTOR LD28763P protein binding#GO:0005515;growth factor receptor binding#GO:0070851;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cellular process#GO:0050794;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 HELRO|EnsemblGenome=HelroG98384|UniProtKB=T1G9M1 T1G9M1 20217767 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015 organelle organization#GO:0006996;cellular component organization#GO:0016043;muscle system process#GO:0003012;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;muscle contraction#GO:0006936;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;system process#GO:0003008;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG162310|UniProtKB=T1ESH9 T1ESH9 20199529 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG64578|UniProtKB=T1FXW7 T1FXW7 20213665 PTHR45875:SF1 METHYLTRANSFERASE N6AMT1 METHYLTRANSFERASE HEMK2 catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG186959|UniProtKB=T1FP49 T1FP49 20210596 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 tubulin#PC00228;cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HELRO|EnsemblGenome=HelroG178817|UniProtKB=T1FDS5 T1FDS5 20206974 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HELRO|EnsemblGenome=HelroG165510|UniProtKB=T1EWY1 T1EWY1 20201081 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191962|UniProtKB=T1FTG5 T1FTG5 20212112 PTHR23072:SF0 PHOSPHATIDYLINOSITOL GLYCAN-RELATED GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2, CATALYTIC SUBUNIT catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;biosynthetic process#GO:0009058;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;phospholipid metabolic process#GO:0006644;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;glycolipid biosynthetic process#GO:0009247 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HELRO|EnsemblGenome=HelroG172847|UniProtKB=T1F603 T1F603 20204252 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG177270|UniProtKB=T1FBF7 T1FBF7 20206156 PTHR28588:SF1 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5 cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG189703|UniProtKB=T1FRA1 T1FRA1 20211348 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170685|UniProtKB=T1F3B4 T1F3B4 20203313 PTHR23055:SF201 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG178925|UniProtKB=T1FDW7 T1FDW7 20207016 PTHR15710:SF261 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE E3 UBIQUITIN TRANSFERASE positive regulation of signal transduction#GO:0009967;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of response to stimulus#GO:0048584;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG114532|UniProtKB=T1EG25 T1EG25 20195527 PTHR48036:SF6 SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED RNA-BINDING MOTIF PROTEIN 39A-RELATED binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG168280|UniProtKB=T1F0E4 T1F0E4 20202294 PTHR10725:SF73 THAP DOMAIN-CONTAINING PROTEIN 9 APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185291|UniProtKB=T1FMM2 T1FMM2 20210071 PTHR14119:SF19 HYDROLASE ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG81938|UniProtKB=T1G4K7 T1G4K7 20216005 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK-1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG163158|UniProtKB=T1ETQ9 T1ETQ9 20199959 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG79884|UniProtKB=T1G3V0 T1G3V0 20215748 PTHR11787:SF8 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG62664|UniProtKB=T1FX33 T1FX33 20213381 PTHR10574:SF375 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-1 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;substrate adhesion-dependent cell spreading#GO:0034446;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;axonogenesis#GO:0007409;neuron development#GO:0048666;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cell migration#GO:0016477;multicellular organismal process#GO:0032501;tissue development#GO:0009888;extracellular matrix assembly#GO:0085029;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;cell-substrate adhesion#GO:0031589;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;system development#GO:0048731;cell motility#GO:0048870 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG168046|UniProtKB=T1F039 T1F039 20202189 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67857|UniProtKB=T1FZ63 T1FZ63 20214111 PTHR10743:SF0 PROTEIN RER1 PROTEIN RER1 protein localization to organelle#GO:0033365;vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;Golgi vesicle transport#GO:0048193;transport#GO:0006810 endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG170901|UniProtKB=T1F3K6 T1F3K6 20203405 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG141083|UniProtKB=T1EJ25 T1EJ25 20196575 PTHR24356:SF447 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE WARTS phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;mitotic cell cycle phase transition#GO:0044772;regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of growth#GO:0040008;regulation of programmed cell death#GO:0043067;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;G1/S transition of mitotic cell cycle#GO:0000082;hippo signaling#GO:0035329;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cell cycle G1/S phase transition#GO:0044843 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG192393|UniProtKB=T1FTW4 T1FTW4 20212261 PTHR10288:SF356 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG86942|UniProtKB=T1G6J6 T1G6J6 20216693 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG162330|UniProtKB=T1ESI6 T1ESI6 20199536 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG67109|UniProtKB=T1FYW5 T1FYW5 20214013 PTHR11208:SF42 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG156211|UniProtKB=T1ELS8 T1ELS8 20197528 PTHR28441:SF2 PROTEIN FAM91A1 PROTEIN FAM91A1 HELRO|EnsemblGenome=HelroG192899|UniProtKB=T1FUE3 T1FUE3 20212439 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG190746|UniProtKB=T1FS93 T1FS93 20211690 PTHR24104:SF47 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED THIN, ISOFORM C ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173784|UniProtKB=T1F781 T1F781 20204680 PTHR12374:SF85 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-ALPHA transcription coregulator activity#GO:0003712;binding#GO:0005488;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG160742|UniProtKB=T1EQN5 T1EQN5 20198885 PTHR24366:SF96 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS REDUCED OCELLI, ISOFORM B immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG72409|UniProtKB=T1G0Z5 T1G0Z5 20214743 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488 response to chemical#GO:0042221;response to stimulus#GO:0050896;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG79813|UniProtKB=T1G3T8 T1G3T8 20215736 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG106357|UniProtKB=T1EE24 T1EE24 20194826 PTHR11255:SF48 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186042|UniProtKB=T1FNL1 T1FNL1 20210408 PTHR13615:SF3 GLYCOSYLTRANSFERASE-LIKE 1 TRNA-QUEUOSINE ALPHA-MANNOSYLTRANSFERASE transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG142808|UniProtKB=T1EJ78 T1EJ78 20196628 PTHR22722:SF14 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED MEGALIN, ISOFORM A hormone binding#GO:0042562;binding#GO:0005488 cellular process#GO:0009987;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 HELRO|EnsemblGenome=HelroG161482|UniProtKB=T1ERJ0 T1ERJ0 20199190 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG94922|UniProtKB=T1G939 T1G939 20217586 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 monoatomic ion transport#GO:0006811;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG108429|UniProtKB=T1EEI8 T1EEI8 20194990 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 steroid hydroxylase activity#GO:0008395;binding#GO:0005488;tetrapyrrole binding#GO:0046906;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491 xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194024|UniProtKB=T1FVK9 T1FVK9 20212855 PTHR10643:SF2 KINETOCHORE PROTEIN NDC80 KINETOCHORE PROTEIN NDC80 HOMOLOG mitotic cell cycle#GO:0000278;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic metaphase chromosome alignment#GO:0007080;organelle fission#GO:0048285;localization#GO:0051179;organelle localization#GO:0051640;nuclear division#GO:0000280;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;chromosome localization#GO:0050000;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059 intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;outer kinetochore#GO:0000940;membraneless organelle#GO:0043228;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG182117|UniProtKB=T1FHS2 T1FHS2 20208371 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167387|UniProtKB=T1EZC0 T1EZC0 20201920 PTHR16133:SF0 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG159686|UniProtKB=T1EPB0 T1EPB0 20198410 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82615|UniProtKB=T1G4U3 T1G4U3 20216091 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG77167|UniProtKB=T1G2T7 T1G2T7 20215385 PTHR22811:SF45 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6 cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;vesicle#GO:0031982;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG177914|UniProtKB=T1FCG5 T1FCG5 20206514 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;proton channel activity#GO:0015252;voltage-gated monoatomic cation channel activity#GO:0022843;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG63750|UniProtKB=T1FXJ8 T1FXJ8 20213546 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG178516|UniProtKB=T1FDA5 T1FDA5 20206804 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158150|UniProtKB=T1EMJ8 T1EMJ8 20197798 PTHR11785:SF528 AMINO ACID TRANSPORTER LD25378P L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;cellular process#GO:0009987;amino acid transport#GO:0006865;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG76722|UniProtKB=T1G2N5 T1G2N5 20215333 PTHR24068:SF129 UBIQUITIN-CONJUGATING ENZYME E2 NEDD8-CONJUGATING ENZYME UBE2F ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG184364|UniProtKB=T1FL21 T1FL21 20209520 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114296|UniProtKB=T1EG06 T1EG06 20195508 PTHR11132:SF427 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E1 active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185978|UniProtKB=T1FNI3 T1FNI3 20210380 PTHR11353:SF21 CHAPERONIN CHAPERONIN CONTAINING TCP1 SUBUNIT 6A-RELATED protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;chaperonin-containing T-complex#GO:0005832;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein folding chaperone complex#GO:0101031 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG111386|UniProtKB=T1EFA8 T1EFA8 20195260 PTHR25462:SF311 BONUS, ISOFORM C-RELATED PROTEIN MEIOTIC P26 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185223|UniProtKB=T1FMJ0 T1FMJ0 20210039 PTHR15315:SF26 RING FINGER PROTEIN 41, 151 E3 UBIQUITIN-PROTEIN LIGASE NRDP1 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 HELRO|EnsemblGenome=HelroG190292|UniProtKB=T1FRV3 T1FRV3 20211550 PTHR22770:SF47 UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF216 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;regulation of localization#GO:0032879;regulation of transport#GO:0051049;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;presynapse#GO:0098793;ubiquitin ligase complex#GO:0000151;cell junction#GO:0030054;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76766|UniProtKB=T1G2P2 T1G2P2 20215340 PTHR23257:SF1008 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG184705|UniProtKB=T1FLT5 T1FLT5 20209784 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG179452|UniProtKB=T1FEQ7 T1FEQ7 20207306 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177986|UniProtKB=T1FCK6 T1FCK6 20206555 PTHR13194:SF18 COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30 COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG78594|UniProtKB=T1G3D6 T1G3D6 20215584 PTHR12609:SF0 MICROTUBULE ASSOCIATED PROTEIN XMAP215 CYTOSKELETON-ASSOCIATED PROTEIN 5 transferase activity#GO:0016740;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;protein-containing complex assembly#GO:0065003;centrosome cycle#GO:0007098;protein polymerization#GO:0051258;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;establishment or maintenance of cell polarity#GO:0007163;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;mitotic cell cycle process#GO:1903047;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298 centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;microtubule plus-end#GO:0035371;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;kinetochore#GO:0000776;microtubule end#GO:1990752;spindle pole#GO:0000922;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG164394|UniProtKB=T1EVD5 T1EVD5 20200535 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183654|UniProtKB=T1FK00 T1FK00 20209149 PTHR12069:SF0 DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5 DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG81165|UniProtKB=T1G4A4 T1G4A4 20215902 PTHR35684:SF2 FAMILY NOT NAMED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG191383|UniProtKB=T1FSY1 T1FSY1 20211928 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172968|UniProtKB=T1F683 T1F683 20204332 PTHR46420:SF1 BETA-1,4-GLUCURONYLTRANSFERASE 1 BETA-1,4-GLUCURONYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG176975|UniProtKB=T1FB31 T1FB31 20206030 PTHR11909:SF428 CASEIN KINASE-RELATED DISCS OVERGROWN PROTEIN KINASE-RELATED protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of signal transduction#GO:0009967;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG127438|UniProtKB=T1EHE7 T1EHE7 20195997 PTHR12441:SF10 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL ATP SYNTHASE PERIPHERAL STALK SUBUNIT F6, MITOCHONDRIAL proton-transporting ATP synthase complex#GO:0045259;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex#GO:0016469 primary active transporter#PC00068;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG188645|UniProtKB=T1FQ77 T1FQ77 20210974 PTHR13103:SF2 SCHWANNOMIN INTERACTING PROTEIN 1 IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of hippo signaling#GO:0035330;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HELRO|EnsemblGenome=HelroG186777|UniProtKB=T1FP34 T1FP34 20210581 PTHR10687:SF96 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;trans-Golgi network membrane#GO:0032588;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG172920|UniProtKB=T1F648 T1F648 20204297 PTHR22923:SF120 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG119254|UniProtKB=T1EGM8 T1EGM8 20195728 PTHR10153:SF44 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN gated channel activity#GO:0022836;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;transporter activity#GO:0005215;calmodulin binding#GO:0005516;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation channel activity#GO:0005261 potassium ion transport#GO:0006813;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;cell body#GO:0044297;neuron projection#GO:0043005;cell periphery#GO:0071944 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG90920|UniProtKB=T1G7Y0 T1G7Y0 20217177 PTHR23040:SF1 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG137215|UniProtKB=T1EII2 T1EII2 20196382 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG170727|UniProtKB=T1F3D1 T1F3D1 20203330 PTHR15487:SF4 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG99392|UniProtKB=T1G9S5 T1G9S5 20217821 PTHR12097:SF0 SPLICING FACTOR 3B, SUBUNIT 1-RELATED SPLICING FACTOR 3B SUBUNIT 1 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397 nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;U2 snRNP#GO:0005686;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG114881|UniProtKB=T1EG52 T1EG52 20195554 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG132380|UniProtKB=T1EHY3 T1EHY3 20196183 PTHR10663:SF402 GUANYL-NUCLEOTIDE EXCHANGE FACTOR MIP16918P cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG174986|UniProtKB=T1F8P4 T1F8P4 20205193 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172506|UniProtKB=T1F5F3 T1F5F3 20204052 PTHR45977:SF4 TARGET OF ERK KINASE MPK-1 RING-TYPE E3 UBIQUITIN TRANSFERASE-RELATED acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941 HELRO|EnsemblGenome=HelroG194539|UniProtKB=T1FW63 T1FW63 20213059 PTHR23204:SF10 CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179416|UniProtKB=T1FEN9 T1FEN9 20207288 PTHR21231:SF7 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 3 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 G-protein#PC00020;protein-binding activity modulator#PC00095;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG114685|UniProtKB=T1EG39 T1EG39 20195541 PTHR21243:SF21 PROTEIN SCAI PROTEIN SCAI transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG168041|UniProtKB=T1F038 T1F038 20202188 PTHR24280:SF4 CYTOCHROME P450 20A1 CYTOCHROME P450 20A1 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG186169|UniProtKB=T1FNR6 T1FNR6 20210463 PTHR24031:SF421 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX28-RELATED mitochondrial ribosome assembly#GO:0061668;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;ribosomal large subunit assembly#GO:0000027;protein-RNA complex assembly#GO:0022618;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;mitochondrial large ribosomal subunit assembly#GO:1902775 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG175652|UniProtKB=T1F9H2 T1F9H2 20205471 PTHR24223:SF474 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG78764|UniProtKB=T1G3F4 T1G3F4 20215602 PTHR24351:SF201 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG101552|UniProtKB=T1ED54 T1ED54 20194506 PTHR45672:SF3 PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5 protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG62173|UniProtKB=T1FWW5 T1FWW5 20213313 PTHR20913:SF7 TBC1 DOMAIN FAMILY MEMBER 20/GTPASE RE60063P enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 Golgi organization#GO:0007030;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular localization#GO:0051641 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG164391|UniProtKB=T1EVD3 T1EVD3 20200533 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG168291|UniProtKB=T1F0E7 T1F0E7 20202297 PTHR15453:SF11 TUMOR SUPPRESSOR CANDIDATE 2 TUMOR SUPPRESSOR CANDIDATE 2 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of membrane potential#GO:0042391 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG182967|UniProtKB=T1FJ03 T1FJ03 20208802 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG193541|UniProtKB=T1FV39 T1FV39 20212685 PTHR24351:SF230 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell communication#GO:0007154;TORC1 signaling#GO:0038202;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;p53 pathway by glucose deprivation#P04397>S6K#P04636;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HELRO|EnsemblGenome=HelroG161001|UniProtKB=T1EQZ6 T1EQZ6 20198996 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165883|UniProtKB=T1EXE5 T1EXE5 20201245 PTHR21207:SF2 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED GH16267P-RELATED Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 HELRO|EnsemblGenome=HelroG187181|UniProtKB=T1FP75 T1FP75 20210622 PTHR10701:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;U2-type prespliceosome#GO:0071004;ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;cytoplasm#GO:0005737;U2 snRNP#GO:0005686;catalytic step 2 spliceosome#GO:0071013;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG177374|UniProtKB=T1FBL1 T1FBL1 20206210 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;cell fate commitment#GO:0045165;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HELRO|EnsemblGenome=HelroG182643|UniProtKB=T1FIJ1 T1FIJ1 20208640 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94219|UniProtKB=T1G8Z4 T1G8Z4 20217541 PTHR11632:SF51 SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;anaerobic respiration#GO:0009061;electron transport chain#GO:0022900;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987 respiratory chain complex II (succinate dehydrogenase)#GO:0045273;cell periphery#GO:0071944;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG173256|UniProtKB=T1F6L8 T1F6L8 20204467 PTHR31516:SF22 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;cytoplasmic microtubule#GO:0005881;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG192857|UniProtKB=T1FUD3 T1FUD3 20212429 PTHR12604:SF2 KU AUTOANTIGEN DNA HELICASE DNA REPAIR PROTEIN KU70 telomeric repeat DNA binding#GO:0042162;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;telomere organization#GO:0032200;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;double-strand break repair via nonhomologous end joining#GO:0006303;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG142152|UniProtKB=T1EJ49 T1EJ49 20196599 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG193900|UniProtKB=T1FVG6 T1FVG6 20212812 PTHR23147:SF22 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;membraneless organelle#GO:0043228;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG110061|UniProtKB=T1EEY9 T1EEY9 20195141 PTHR45819:SF5 CENTAURIN-GAMMA-1A CENTAURIN-GAMMA-1A catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function activator activity#GO:0140677 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG94333|UniProtKB=T1G902 T1G902 20217549 PTHR11406:SF0 PHOSPHOGLYCERATE KINASE PHOSPHOGLYCERATE KINASE small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;phosphoglycerate kinase activity#GO:0004618;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;phosphotransferase activity, carboxyl group as acceptor#GO:0016774;transferase activity, transferring phosphorus-containing groups#GO:0016772;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine nucleotide binding#GO:0017076;transferase activity#GO:0016740;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;kinase activity#GO:0016301;ribonucleotide binding#GO:0032553 purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;ADP catabolic process#GO:0046032;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;nucleoside diphosphate catabolic process#GO:0009134;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;purine nucleotide catabolic process#GO:0006195;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;small molecule biosynthetic process#GO:0044283;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ribonucleoside diphosphate metabolic process#GO:0009185;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;gluconeogenesis#GO:0006094;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphoglycerate kinase#P00671 HELRO|EnsemblGenome=HelroG122109|UniProtKB=T1EGU0 T1EGU0 20195790 PTHR11537:SF294 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;action potential#GO:0001508;metal ion transport#GO:0030001 plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;voltage-gated potassium channel complex#GO:0008076;neuron projection membrane#GO:0032589;axon terminus#GO:0043679;cell body#GO:0044297;postsynapse#GO:0098794;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;cell projection membrane#GO:0031253;neuron projection#GO:0043005;presynapse#GO:0098793;cell leading edge#GO:0031252;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG69793|UniProtKB=T1FZY5 T1FZY5 20214383 PTHR42996:SF1 PHOSPHATE-BINDING PROTEIN PSTS PHOSPHATE-BINDING PROTEIN PSTS establishment of localization#GO:0051234;localization#GO:0051179;phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698;transport#GO:0006810 primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG110978|UniProtKB=T1EF68 T1EF68 20195220 PTHR12928:SF0 FRG1 PROTEIN PROTEIN FRG1 nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG189088|UniProtKB=T1FQM5 T1FQM5 20211122 PTHR13518:SF1 PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER RGD1306746 PROTEIN cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG66737|UniProtKB=T1FYQ1 T1FYQ1 20213949 PTHR14233:SF4 DUF914-RELATED SOLUTE CARRIER FAMILY 35 MEMBER F2 HELRO|EnsemblGenome=HelroG183013|UniProtKB=T1FJ31 T1FJ31 20208830 PTHR15592:SF14 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG188150|UniProtKB=T1FPP8 T1FPP8 20210795 PTHR11208:SF45 RNA-BINDING PROTEIN RELATED SPLICING FACTOR 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG192329|UniProtKB=T1FTU1 T1FTU1 20212238 PTHR12929:SF10 SOLUTE CARRIER FAMILY 52 RIBOFLAVIN TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 nitrogen compound transport#GO:0071705;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vitamin transport#GO:0051180 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG165194|UniProtKB=T1EWE9 T1EWE9 20200899 PTHR21538:SF23 ANILLIN/RHOTEKIN RTKN ANILLIN mitotic cell cycle#GO:0000278;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;actomyosin structure organization#GO:0031032;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cell division#GO:0051301;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640;septin ring organization#GO:0031106;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actomyosin contractile ring assembly#GO:0000915;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;septin cytoskeleton organization#GO:0032185 intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;membraneless organelle#GO:0043228;actomyosin contractile ring#GO:0005826;contractile ring#GO:0070938;cytoskeleton#GO:0005856;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;cell periphery#GO:0071944 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG93092|UniProtKB=T1G8T2 T1G8T2 20217479 PTHR36181:SF4 INTRON-ENCODED ENDONUCLEASE AI3-RELATED LAGLIDADG ENDONUCLEASE HELRO|EnsemblGenome=HelroG94381|UniProtKB=T1G907 T1G907 20217554 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MULTIDRUG RESISTANCE PROTEIN HOMOLOG 49-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG108214|UniProtKB=T1EEH0 T1EEH0 20194972 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG168846|UniProtKB=T1F113 T1F113 20202513 PTHR15683:SF8 SCAFFOLD ATTACHMENT FACTOR B-RELATED SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG185292|UniProtKB=T1FMM3 T1FMM3 20210072 PTHR21064:SF1 AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED HYDROXYLYSINE KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 HELRO|EnsemblGenome=HelroG186524|UniProtKB=T1FP05 T1FP05 20210552 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG74476|UniProtKB=T1G1R7 T1G1R7 20215015 PTHR12970:SF1 PROTEASOME ASSEMBLY CHAPERONE 2 PROTEASOME ASSEMBLY CHAPERONE 2 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG83783|UniProtKB=T1G5A3 T1G5A3 20216250 PTHR11255:SF127 DIACYLGLYCEROL KINASE EYE-SPECIFIC DIACYLGLYCEROL KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;neutral lipid metabolic process#GO:0006638;signal transduction#GO:0007165;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610 cellular anatomical structure#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;kinase#PC00137 HELRO|EnsemblGenome=HelroG170977|UniProtKB=T1F3N5 T1F3N5 20203434 PTHR11782:SF127 ADENOSINE/GUANOSINE DIPHOSPHATASE NUCLEOSIDE DIPHOSPHATE PHOSPHATASE hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110 organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleoside diphosphate metabolic process#GO:0009132;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG170315|UniProtKB=T1F2X0 T1F2X0 20203169 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;potassium ion transmembrane transporter activity#GO:0015079 monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG156872|UniProtKB=T1EM23 T1EM23 20197623 PTHR13449:SF2 INTEGRAL MEMBRANE PROTEIN GPR177 PROTEIN WNTLESS HOMOLOG binding#GO:0005488;Wnt-protein binding#GO:0017147;protein binding#GO:0005515 regulation of biological process#GO:0050789;protein localization to extracellular region#GO:0071692;signaling#GO:0023052;export from cell#GO:0140352;signal release#GO:0023061;secretion by cell#GO:0032940;protein transport#GO:0015031;protein secretion#GO:0009306;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to extracellular region#GO:0035592;establishment of localization#GO:0051234 membrane#GO:0016020;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG163587|UniProtKB=T1EU92 T1EU92 20200142 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD LICD_FKTN_FKRP NUCLEOTIDYLTRANSFERASE DOMAIN-CONTAINING PROTEIN transferase#PC00220 HELRO|EnsemblGenome=HelroG178248|UniProtKB=T1FCZ7 T1FCZ7 20206696 PTHR13264:SF5 GCIP-INTERACTING PROTEIN P29 PRE-MRNA-SPLICING FACTOR SYF2 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG75246|UniProtKB=T1G229 T1G229 20215127 PTHR20383:SF9 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG112795|UniProtKB=T1EFM2 T1EFM2 20195374 PTHR11699:SF315 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG79045|UniProtKB=T1G3J2 T1G3J2 20215640 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G2/M phase transition#GO:0044839;regulation of cell cycle G2/M phase transition#GO:1902749;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;mitotic cell cycle phase transition#GO:0044772;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;regulation of meiotic cell cycle#GO:0051445;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle#GO:0051726;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG92607|UniProtKB=T1G8I9 T1G8I9 20217386 PTHR11537:SF294 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 axon terminus#GO:0043679;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;presynaptic membrane#GO:0042734;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuron projection terminus#GO:0044306;neuronal cell body#GO:0043025;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;neuron projection#GO:0043005;presynapse#GO:0098793;cell leading edge#GO:0031252;cell projection membrane#GO:0031253;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell body#GO:0044297;postsynapse#GO:0098794 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG91778|UniProtKB=T1G887 T1G887 20217284 PTHR23506:SF26 GH10249P MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;monoamine transmembrane transporter activity#GO:0008504;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG184399|UniProtKB=T1FL44 T1FL44 20209543 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG186674|UniProtKB=T1FP23 T1FP23 20210570 PTHR14381:SF1 DACTYLIN F-BOX_WD REPEAT-CONTAINING PROTEIN 4 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 response to stress#GO:0006950;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;response to stimulus#GO:0050896;catabolic process#GO:0009056;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538 transferase complex#GO:1990234;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HELRO|EnsemblGenome=HelroG73452|UniProtKB=T1G1E0 T1G1E0 20214888 PTHR21255:SF4 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG69385|UniProtKB=T1FZU4 T1FZU4 20214342 PTHR45877:SF2 E3 UBIQUITIN-PROTEIN LIGASE SIAH2 E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED ubiquitin-protein ligase#PC00234 Wnt signaling pathway#P00057>SIAH-1#P01433 HELRO|EnsemblGenome=HelroG168960|UniProtKB=T1F172 T1F172 20202572 PTHR18867:SF12 RAD50 DNA REPAIR PROTEIN RAD50 single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;DNA binding#GO:0003677 reproductive process#GO:0022414;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;telomere organization#GO:0032200;sexual reproduction#GO:0019953;mitotic recombination#GO:0006312;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;RNA-templated DNA biosynthetic process#GO:0006278;DNA repair#GO:0006281;response to stimulus#GO:0050896;cell cycle process#GO:0022402;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654 condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG171028|UniProtKB=T1F3Q4 T1F3Q4 20203453 PTHR21043:SF0 IOJAP SUPERFAMILY ORTHOLOG MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1 binding#GO:0005488;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;ribosomal large subunit binding#GO:0043023 protein-containing complex organization#GO:0043933;mitochondrial ribosome assembly#GO:0061668;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;ribosomal large subunit assembly#GO:0000027;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-RNA complex assembly#GO:0022618;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;mitochondrial large ribosomal subunit assembly#GO:1902775 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG193631|UniProtKB=T1FV76 T1FV76 20212722 PTHR45769:SF3 ADENOSINE KINASE ADENOSINE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;nucleoside kinase activity#GO:0019206 nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;metabolic process#GO:0008152;purine nucleobase metabolic process#GO:0006144;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG172356|UniProtKB=T1F579 T1F579 20203978 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169759|UniProtKB=T1F2A9 T1F2A9 20202959 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP-TYPE DOMAIN-CONTAINING PROTEIN zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG135646|UniProtKB=T1EI99 T1EI99 20196299 PTHR23235:SF60 KRUEPPEL-LIKE TRANSCRIPTION FACTOR STRIPE, ISOFORM D sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG186760|UniProtKB=T1FP31 T1FP31 20210578 PTHR48105:SF37 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN-DISULFIDE REDUCTASE (NADPH) disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209 cell redox homeostasis#GO:0045454;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG145664|UniProtKB=T1EJL9 T1EJL9 20196769 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG153264|UniProtKB=T1EL21 T1EL21 20197271 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182949|UniProtKB=T1FIY9 T1FIY9 20208788 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG62592|UniProtKB=T1FX26 T1FX26 20213374 PTHR10357:SF237 ALPHA-GLUCOSIDASE FAMILY MEMBER ALPHA-GLUCOSIDASE carbohydrate catabolic process#GO:0016052;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;catabolic process#GO:0009056;oligosaccharide catabolic process#GO:0009313;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;amylase#PC00048 HELRO|EnsemblGenome=HelroG190506|UniProtKB=T1FS20 T1FS20 20211617 PTHR19848:SF10 WD40 REPEAT PROTEIN NOTCHLESS PROTEIN HOMOLOG 1 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG79049|UniProtKB=T1G3J3 T1G3J3 20215641 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HELRO|EnsemblGenome=HelroG84578|UniProtKB=T1G5K5 T1G5K5 20216352 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG106804|UniProtKB=T1EE51 T1EE51 20194853 PTHR10343:SF84 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 protein binding#GO:0005515;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein-binding activity modulator#PC00095;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG108178|UniProtKB=T1EEG2 T1EEG2 20194964 PTHR15627:SF8 NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG62237|UniProtKB=T1FWX6 T1FWX6 20213324 PTHR24248:SF120 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG72963|UniProtKB=T1G179 T1G179 20214827 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cell junction#GO:0030054;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG166296|UniProtKB=T1EY00 T1EY00 20201450 PTHR13248:SF4 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 ELONGIN-B transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of gene silencing by regulatory ncRNA#GO:0060966;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;modification-dependent protein catabolic process#GO:0019941;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;post-transcriptional gene silencing#GO:0016441;positive regulation of biosynthetic process#GO:0009891;protein metabolic process#GO:0019538;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;post-transcriptional regulation of gene expression#GO:0010608;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511 organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG162304|UniProtKB=T1ESH3 T1ESH3 20199523 PTHR19282:SF417 TETRASPANIN TOBAMOVIRUS MULTIPLICATION PROTEIN 2A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84860|UniProtKB=T1G5P7 T1G5P7 20216394 PTHR22957:SF704 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG107075|UniProtKB=T1EE72 T1EE72 20194874 PTHR19924:SF26 UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase I#GO:0045943;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of RNA biosynthetic process#GO:1902680;biosynthetic process#GO:0009058;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of transcription by RNA polymerase I#GO:0006356 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG176859|UniProtKB=T1FAZ6 T1FAZ6 20205995 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62884|UniProtKB=T1FX66 T1FX66 20213414 PTHR24406:SF42 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG194359|UniProtKB=T1FVZ4 T1FVZ4 20212990 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG enzyme activator activity#GO:0008047;binding#GO:0005488;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein-containing complex binding#GO:0044877 regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;protein metabolic process#GO:0019538;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;proteasomal protein catabolic process#GO:0010498 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194764|UniProtKB=T1FWE0 T1FWE0 20213135 PTHR12307:SF36 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT polysaccharide binding#GO:0030247;phosphatase binding#GO:0019902;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;carbohydrate binding#GO:0030246;protein phosphatase binding#GO:0019903 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of polysaccharide metabolic process#GO:0032881;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of carbohydrate metabolic process#GO:0006109;regulation of glycogen biosynthetic process#GO:0005979 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG184462|UniProtKB=T1FL91 T1FL91 20209590 PTHR16089:SF40 REST COREPRESSOR COREST PROTEIN-RELATED SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164475|UniProtKB=T1EVH0 T1EVH0 20200570 PTHR14130:SF14 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 92B enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG157396|UniProtKB=T1EMA9 T1EMA9 20197709 PTHR45794:SF1 LEUCYL-TRNA SYNTHETASE LEUCINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG77640|UniProtKB=T1G314 T1G314 20215462 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER LD05335P transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873 zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;transport#GO:0006810;zinc ion transmembrane transport#GO:0071577 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG102143|UniProtKB=T1ED83 T1ED83 20194535 PTHR19375:SF169 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 13 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein refolding#GO:0042026;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Hsp70 family chaperone#PC00027;chaperone#PC00072 HELRO|EnsemblGenome=HelroG62045|UniProtKB=T1FWU5 T1FWU5 20213293 PTHR24083:SF103 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR RXR transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;intracellular receptor signaling pathway#GO:0030522;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG190271|UniProtKB=T1FRU5 T1FRU5 20211542 PTHR24404:SF78 ZINC FINGER PROTEIN ZINC FINGER PROTEIN ZTF-16 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG170854|UniProtKB=T1F3I5 T1F3I5 20203384 PTHR43981:SF2 ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;reductase#PC00198 HELRO|EnsemblGenome=HelroG172104|UniProtKB=T1F512 T1F512 20203911 PTHR24390:SF230 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 362 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG65661|UniProtKB=T1FYB3 T1FYB3 20213811 PTHR11132:SF255 SOLUTE CARRIER FAMILY 35 GDP-FUCOSE TRANSPORTER 1 nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297 transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleotide-sugar transmembrane transport#GO:0015780;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG188224|UniProtKB=T1FPS5 T1FPS5 20210822 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG167619|UniProtKB=T1EZK7 T1EZK7 20202007 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194349|UniProtKB=T1FVY9 T1FVY9 20212985 PTHR12433:SF11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189610|UniProtKB=T1FR73 T1FR73 20211320 PTHR11106:SF123 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 carbohydrate derivative metabolic process#GO:1901135;purine-containing compound metabolic process#GO:0072521;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;purine nucleoside metabolic process#GO:0042278;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG112437|UniProtKB=T1EFJ9 T1EFJ9 20195351 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG164050|UniProtKB=T1EUU0 T1EUU0 20200340 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG194022|UniProtKB=T1FVK7 T1FVK7 20212853 PTHR46507:SF4 AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN SYNOVIAL SARCOMA, X BREAKPOINT 2 INTERACTING PROTEIN B microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cilium assembly#GO:0060271;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;intraciliary transport involved in cilium assembly#GO:0035735;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607 centriolar satellite#GO:0034451;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG117142|UniProtKB=T1EGK6 T1EGK6 PTHR24291:SF48 CYTOCHROME P450 FAMILY 4 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG109371|UniProtKB=T1EES8 T1EES8 20195080 PTHR43690:SF37 NARDILYSIN INSULIN-DEGRADING ENZYME metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG177733|UniProtKB=T1FC56 T1FC56 20206405 PTHR23309:SF58 3-HYDROXYACYL-COA DEHYROGENASE 3-HYDROXYACYL-COA DEHYDROGENASE NAD BINDING DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG105374|UniProtKB=T1EDU2 T1EDU2 20194744 PTHR19961:SF81 FIMBRIN/PLASTIN FI19014P1 binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;molecular adaptor activity#GO:0060090;cytoskeletal protein binding#GO:0008092 supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG166576|UniProtKB=T1EY96 T1EY96 20201546 PTHR16489:SF12 GH11727P GH11727P molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cellular response to stress#GO:0033554;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;response to stress#GO:0006950;response to stimulus#GO:0050896 endoplasmic reticulum#GO:0005783;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG102762|UniProtKB=T1EDB5 T1EDB5 20194567 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG93158|UniProtKB=T1G8U2 T1G8U2 20217489 PTHR11787:SF8 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG165642|UniProtKB=T1EX42 T1EX42 20201142 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66303|UniProtKB=T1FYJ5 T1FYJ5 20213893 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG spermatid differentiation#GO:0048515;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;reproductive process#GO:0022414;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;motile cilium#GO:0031514;organelle#GO:0043226;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG122800|UniProtKB=T1EGW0 T1EGW0 20195810 PTHR11132:SF515 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER D3 antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185231|UniProtKB=T1FMJ4 T1FMJ4 20210043 PTHR47385:SF14 CALPONIN TRANSGELIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189247|UniProtKB=T1FQV2 T1FQV2 20211199 PTHR46584:SF1 HMG DOMAIN-CONTAINING PROTEIN 4 HMG DOMAIN-CONTAINING PROTEIN 4 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG153250|UniProtKB=T1EL16 T1EL16 20197266 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG147455|UniProtKB=T1EK06 T1EK06 20196906 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG73647|UniProtKB=T1G1G8 T1G1G8 20214916 PTHR13232:SF10 NAD(P)H-HYDRATE EPIMERASE NAD(P)H-HYDRATE EPIMERASE metabolite interconversion enzyme#PC00262;epimerase/racemase#PC00096 HELRO|EnsemblGenome=HelroG193322|UniProtKB=T1FUV9 T1FUV9 20212605 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402 HELRO|EnsemblGenome=HelroG96079|UniProtKB=T1G9A2 T1G9A2 20217649 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70729|UniProtKB=T1G0B3 T1G0B3 20214511 PTHR45793:SF5 HOMEOBOX PROTEIN HOMEOTIC PROTEIN OCELLILESS DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;cell fate specification#GO:0001708;developmental process#GO:0032502;neuron differentiation#GO:0030182 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG97598|UniProtKB=T1G9H9 T1G9H9 20217726 PTHR13114:SF7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185361|UniProtKB=T1FMQ3 T1FMQ3 20210102 PTHR19282:SF456 TETRASPANIN FI23944P1-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91316|UniProtKB=T1G825 T1G825 20217222 PTHR10857:SF106 COPINE NICOTINIC RECEPTOR-ASSOCIATED PROTEIN 1 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 response to chemical#GO:0042221;response to stimulus#GO:0050896;response to calcium ion#GO:0051592;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to metal ion#GO:0010038 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG129617|UniProtKB=T1EHR7 T1EHR7 20196117 PTHR24238:SF83 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62577|UniProtKB=T1FX25 T1FX25 20213373 PTHR12486:SF4 APRATAXIN-RELATED APRATAXIN double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;hydrolase activity#GO:0016787;RNA binding#GO:0003723;single-stranded DNA binding#GO:0003697;double-stranded RNA binding#GO:0003725;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity, acting on acid anhydrides#GO:0016817;damaged DNA binding#GO:0003684;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG193589|UniProtKB=T1FV54 T1FV54 20212700 PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032;CCKR signaling map#P06959>MEF2D#P07048 HELRO|EnsemblGenome=HelroG185546|UniProtKB=T1FMY9 T1FMY9 20210188 PTHR12396:SF63 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG73742|UniProtKB=T1G1H9 T1G1H9 20214927 PTHR46131:SF1 SD08549P SD08549P purine nucleotide transmembrane transporter activity#GO:0015216;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG108537|UniProtKB=T1EEK0 T1EEK0 20195002 PTHR45622:SF82 UBIQUITIN-PROTEIN LIGASE E3A-RELATED UBIQUITIN-PROTEIN LIGASE E3A transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;metabolic process#GO:0008152;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of protein catabolic process#GO:0042176;protein modification by small protein conjugation or removal#GO:0070647;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG81462|UniProtKB=T1G4E5 T1G4E5 20215943 PTHR10698:SF0 V-TYPE PROTON ATPASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT H homeostatic process#GO:0042592;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;vacuolar acidification#GO:0007035;cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008;intracellular chemical homeostasis#GO:0055082;regulation of pH#GO:0006885;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;regulation of intracellular pH#GO:0051453 membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495 ATP synthase#PC00002;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG88241|UniProtKB=T1G705 T1G705 20216852 PTHR13409:SF0 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51 LARGE RIBOSOMAL SUBUNIT PROTEIN ML51 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG78293|UniProtKB=T1G3A4 T1G3A4 20215552 PTHR47633:SF4 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186113|UniProtKB=T1FNN8 T1FNN8 20210435 PTHR11117:SF2 SUCCINYL-COA LIGASE SUBUNIT ALPHA SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;ligase#PC00142 TCA cycle#P00051>Succinyl CoA Synthetase#P01274 HELRO|EnsemblGenome=HelroG179147|UniProtKB=T1FE90 T1FE90 20207139 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189170|UniProtKB=T1FQQ9 T1FQQ9 20211156 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG181129|UniProtKB=T1FGN2 T1FGN2 20207981 PTHR33244:SF8 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158375|UniProtKB=T1EMQ3 T1EMQ3 20197853 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG89153|UniProtKB=T1G792 T1G792 20216939 PTHR18919:SF156 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 steroid metabolic process#GO:0008202;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;acyltransferase#PC00042 CCKR signaling map#P06959>ACAT1#G06992;CCKR signaling map#P06959>ACAT1#G07285 HELRO|EnsemblGenome=HelroG166002|UniProtKB=T1EXK4 T1EXK4 20201304 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193294|UniProtKB=T1FUU5 T1FUU5 20212591 PTHR15346:SF0 DYNACTIN SUBUNIT DYNACTIN SUBUNIT 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093;protein-membrane adaptor activity#GO:0043495 mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;cytoskeleton organization#GO:0007010;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;mitotic spindle organization#GO:0007052;establishment of organelle localization#GO:0051656;nuclear migration#GO:0007097;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850 intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 microtubule binding motor protein#PC00156;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG113490|UniProtKB=T1EFS8 T1EFS8 20195430 PTHR12548:SF9 TRANSCRIPTION FACTOR DP TRANSCRIPTION FACTOR DP DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG88291|UniProtKB=T1G712 T1G712 20216859 PTHR23505:SF79 SPINSTER PROTEIN SPINSTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG186861|UniProtKB=T1FP42 T1FP42 20210589 PTHR22573:SF2 PHOSPHOHEXOMUTASE FAMILY MEMBER PHOSPHOGLUCOMUTASE 1 isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;intramolecular phosphotransferase activity#GO:0016868 carbohydrate metabolic process#GO:0005975;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 isomerase#PC00135;metabolite interconversion enzyme#PC00262;mutase#PC00160 HELRO|EnsemblGenome=HelroG195024|UniProtKB=T1FWN7 T1FWN7 20213232 PTHR47508:SF1 SAM DOMAIN-CONTAINING PROTEIN-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG182242|UniProtKB=T1FHZ5 T1FHZ5 20208444 PTHR24107:SF2 YNEIN REGULATORY COMPLEX SUBUNIT 5 NLR FAMILY CARD DOMAIN CONTAINING 3 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG189760|UniProtKB=T1FRC5 T1FRC5 20211372 PTHR19861:SF0 WD40 REPEAT PROTEIN SWD2 WD REPEAT-CONTAINING PROTEIN 82 binding#GO:0005488;chromatin binding#GO:0003682 transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG175131|UniProtKB=T1F8W4 T1F8W4 20205263 PTHR10019:SF12 SNF5 SWI_SNF CHROMATIN-REMODELING COMPLEX SUBUNIT transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG168634|UniProtKB=T1F0T6 T1F0T6 20202436 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182048|UniProtKB=T1FHN2 T1FHN2 20208331 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG68816|UniProtKB=T1FZK0 T1FZK0 20214248 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG111962|UniProtKB=T1EFG0 T1EFG0 20195312 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER IP12869P transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028 localization#GO:0051179;establishment of localization#GO:0051234;monocarboxylic acid transport#GO:0015718;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG75380|UniProtKB=T1G244 T1G244 20215142 PTHR12241:SF39 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL9-RELATED ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;tubulin binding#GO:0015631;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG191750|UniProtKB=T1FT96 T1FT96 20212043 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG189386|UniProtKB=T1FR06 T1FR06 20211253 PTHR10177:SF584 CYCLINS CYCLIN G protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG150569|UniProtKB=T1EKG1 T1EKG1 20197061 PTHR43840:SF13 MITOCHONDRIAL METAL TRANSPORTER 1-RELATED CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG191266|UniProtKB=T1FST4 T1FST4 20211881 PTHR24366:SF174 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS IG-LIKE DOMAIN-CONTAINING PROTEIN immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG80372|UniProtKB=T1G3Z9 T1G3Z9 20215797 PTHR24235:SF34 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR 11-RELATED peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG181388|UniProtKB=T1FGY4 T1FGY4 20208083 PTHR22792:SF131 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN LARP4B mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG173421|UniProtKB=T1F6T0 T1F6T0 20204529 PTHR48031:SF7 SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL RNA-BINDING PROTEIN 18-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 HELRO|EnsemblGenome=HelroG130121|UniProtKB=T1EHT1 T1EHT1 20196131 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG191960|UniProtKB=T1FTG3 T1FTG3 20212110 PTHR18934:SF109 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG113698|UniProtKB=T1EFV3 T1EFV3 20195455 PTHR12558:SF9 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 16 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 regulation of chromosome separation#GO:1905818;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;positive regulation of cell cycle#GO:0045787;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of chromosome segregation#GO:0051983;positive regulation of mitotic nuclear division#GO:0045840;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;protein modification by small protein conjugation#GO:0032446;regulation of organelle organization#GO:0033043;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of organelle organization#GO:0010638;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;positive regulation of cellular component organization#GO:0051130;anaphase-promoting complex-dependent catabolic process#GO:0031145;modification-dependent macromolecule catabolic process#GO:0043632;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;post-translational protein modification#GO:0043687;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;macromolecule metabolic process#GO:0043170;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of mitotic cell cycle#GO:0045931;regulation of chromosome organization#GO:0033044;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;catabolic process#GO:0009056;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;cell division#GO:0051301;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185063|UniProtKB=T1FMC5 T1FMC5 20209974 PTHR19818:SF166 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG180236|UniProtKB=T1FFL7 T1FFL7 20207616 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG73357|UniProtKB=T1G1D1 T1G1D1 20214879 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178936|UniProtKB=T1FDX5 T1FDX5 20207024 PTHR45889:SF8 IG-LIKE DOMAIN-CONTAINING PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188474|UniProtKB=T1FQ12 T1FQ12 20210909 PTHR10671:SF116 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG191761|UniProtKB=T1FTA5 T1FTA5 20212052 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG194832|UniProtKB=T1FWG7 T1FWG7 20213162 PTHR45854:SF3 ASAP FAMILY MEMBER ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG177042|UniProtKB=T1FB63 T1FB63 20206062 PTHR12881:SF10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG189258|UniProtKB=T1FQV7 T1FQV7 20211204 PTHR24416:SF611 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;Wnt-protein binding#GO:0017147;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;axon#GO:0030424;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188005|UniProtKB=T1FPJ4 T1FPJ4 20210741 PTHR23206:SF8 MASK PROTEIN ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1 response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG175870|UniProtKB=T1F9T0 T1F9T0 20205579 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156024|UniProtKB=T1ELQ8 T1ELQ8 20197508 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 binding#GO:0005488;protein binding#GO:0005515 protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG77319|UniProtKB=T1G2W1 T1G2W1 20215409 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740;glutathione transferase activity#GO:0004364 cellular process#GO:0009987;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790 transferase#PC00220 HELRO|EnsemblGenome=HelroG163066|UniProtKB=T1ETM3 T1ETM3 20199923 PTHR13946:SF16 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-A nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190121|UniProtKB=T1FRP7 T1FRP7 20211494 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG181830|UniProtKB=T1FHE0 T1FHE0 20208239 PTHR16528:SF2 GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879 Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network transport vesicle#GO:0030140;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185620|UniProtKB=T1FN19 T1FN19 20210218 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG63394|UniProtKB=T1FXF3 T1FXF3 20213501 PTHR34095:SF1 39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML55 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG96981|UniProtKB=T1G9E8 T1G9E8 20217695 PTHR33904:SF1 ESSENTIAL MCU REGULATOR, MITOCHONDRIAL ESSENTIAL MCU REGULATOR, MITOCHONDRIAL establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;mitochondrial calcium ion homeostasis#GO:0051560;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;transporter complex#GO:1990351;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG102635|UniProtKB=T1EDA6 T1EDA6 20194558 PTHR46205:SF3 LOQUACIOUS, ISOFORM B PROTEIN LOQUACIOUS RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;siRNA processing#GO:0030422;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG189729|UniProtKB=T1FRA9 T1FRA9 20211356 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG75936|UniProtKB=T1G2C9 T1G2C9 20215227 PTHR23003:SF51 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE-ARGININE PROTEIN 55 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG189155|UniProtKB=T1FQQ3 T1FQQ3 20211150 PTHR21704:SF18 NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED NIPPED-B PROTEIN binding#GO:0005488;chromatin binding#GO:0003682 cellular response to stress#GO:0033554;cellular component organization#GO:0016043;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;recombinational repair#GO:0000725;sister chromatid cohesion#GO:0007062;localization#GO:0051179;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;mitotic cell cycle#GO:0000278;DNA repair#GO:0006281;DNA damage response#GO:0006974;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;mitotic sister chromatid cohesion#GO:0007064;nucleobase-containing compound metabolic process#GO:0006139 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG175519|UniProtKB=T1F9C6 T1F9C6 20205425 PTHR30060:SF0 INNER MEMBRANE PROTEIN COILED-COIL PROTEIN (DUF2040)-RELATED HELRO|EnsemblGenome=HelroG175765|UniProtKB=T1F9M3 T1F9M3 20205522 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163374|UniProtKB=T1ETZ1 T1ETZ1 20200041 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74506|UniProtKB=T1G1S0 T1G1S0 20215018 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG75559|UniProtKB=T1G264 T1G264 20215162 PTHR24031:SF68 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX51 ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164457|UniProtKB=T1EVF9 T1EVF9 20200559 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181310|UniProtKB=T1FGV9 T1FGV9 20208058 PTHR31402:SF2 UPF0711 PROTEIN C18ORF21 RIBONUCLEASE MRP PROTEIN SUBUNIT P24 HELRO|EnsemblGenome=HelroG165432|UniProtKB=T1EWS2 T1EWS2 20201022 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG92246|UniProtKB=T1G8D5 T1G8D5 20217332 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG69117|UniProtKB=T1FZP8 T1FZP8 20214296 PTHR12566:SF19 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB TRANSLATIONAL REGULATOR ORB2 translation regulator activity#GO:0045182;mRNA 3'-UTR binding#GO:0003730;translation factor activity#GO:0180051;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;negative regulation of translation#GO:0017148;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;gamete generation#GO:0007276;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;developmental process involved in reproduction#GO:0003006;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;spermatogenesis#GO:0007283;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;male gamete generation#GO:0048232;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell junction#GO:0030054;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;nucleus#GO:0005634;neuron projection#GO:0043005 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG108980|UniProtKB=T1EEP6 T1EEP6 20195048 PTHR13914:SF0 PROLINE OXIDASE PROLINE DEHYDROGENASE-RELATED ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166 amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidase#PC00175 Huntington disease#P00029>Proline oxidase#G01529 HELRO|EnsemblGenome=HelroG65423|UniProtKB=T1FY76 T1FY76 20213774 PTHR47958:SF11 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640 sexual reproduction#GO:0019953;developmental process#GO:0032502;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;cellular process#GO:0009987;germ cell development#GO:0007281;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG158794|UniProtKB=T1EN98 T1EN98 20198048 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG174579|UniProtKB=T1F898 T1F898 20205047 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG180273|UniProtKB=T1FFN6 T1FFN6 20207635 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71023|UniProtKB=T1G0F9 T1G0F9 20214557 PTHR11309:SF152 FRIZZLED PROTEIN SMOOTHENED protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147;signaling receptor activity#GO:0038023;signaling receptor binding#GO:0005102;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;system development#GO:0048731;smoothened signaling pathway#GO:0007224;pattern specification process#GO:0007389;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;non-canonical Wnt signaling pathway#GO:0035567;cellular response to stimulus#GO:0051716 dendrite#GO:0030425;dendritic tree#GO:0097447;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 transmembrane signal receptor#PC00197 Hedgehog signaling pathway#P00025>Smoothened#P00685 HELRO|EnsemblGenome=HelroG186326|UniProtKB=T1FNY6 T1FNY6 20210533 PTHR23139:SF9 RNA-BINDING PROTEIN SPLICING FACTOR U2AF 65 KDA SUBUNIT RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;binding#GO:0005488;nucleic acid binding#GO:0003676;pre-mRNA binding#GO:0036002 biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear speck#GO:0016607;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG180381|UniProtKB=T1FFV1 T1FFV1 20207700 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160941|UniProtKB=T1EQW0 T1EQW0 20198960 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193411|UniProtKB=T1FUY9 T1FUY9 20212635 PTHR43999:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 2 DNAJ HOMOLOG SUBFAMILY C MEMBER 2 binding#GO:0005488;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;protein binding#GO:0005515;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;Hsp70 protein binding#GO:0030544 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG190410|UniProtKB=T1FRZ0 T1FRZ0 20211587 PTHR13516:SF30 RIBONUCLEASE P SUBUNIT P25 FI09323P RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular protein-containing complex#GO:0140535;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;protein-containing complex#GO:0032991;ribonuclease MRP complex#GO:0000172 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG181812|UniProtKB=T1FHD1 T1FHD1 20208230 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;cell migration#GO:0016477;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG163707|UniProtKB=T1EUD7 T1EUD7 20200187 PTHR11849:SF195 ETS GA-BINDING PROTEIN ALPHA CHAIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG156044|UniProtKB=T1ELR0 T1ELR0 20197510 PTHR34524:SF6 CALCYPHOSIN CALCYPHOSINE LIKE calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG64347|UniProtKB=T1FXT2 T1FXT2 20213630 PTHR48015:SF33 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE HIPPO protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of signal transduction#GO:0009968;hippo signaling#GO:0035329;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG89898|UniProtKB=T1G7J0 T1G7J0 20217037 PTHR11431:SF75 FERRITIN FERRITIN iron ion binding#GO:0005506;ferrous iron binding#GO:0008198;metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 storage protein#PC00210 HELRO|EnsemblGenome=HelroG168166|UniProtKB=T1F094 T1F094 20202244 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68489|UniProtKB=T1FZF4 T1FZF4 20214202 PTHR12847:SF9 ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED NECAP-LIKE PROTEIN CG9132 protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle coat#GO:0030120;membrane#GO:0016020;vesicle membrane#GO:0012506;clathrin-coated vesicle membrane#GO:0030665;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle#GO:0030136;clathrin vesicle coat#GO:0030125;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG106264|UniProtKB=T1EE12 T1EE12 20194814 PTHR10190:SF16 EYES ABSENT PROTEIN PHOSPHATASE EYA catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of DNA repair#GO:0045739;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;developmental process#GO:0032502;cellular developmental process#GO:0048869;positive regulation of DNA metabolic process#GO:0051054;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of cellular response to stress#GO:0080135 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG157741|UniProtKB=T1EMF2 T1EMF2 20197752 PTHR24073:SF352 DRAB5-RELATED RAS-RELATED PROTEIN RAB6 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 cytosolic transport#GO:0016482;intra-Golgi vesicle-mediated transport#GO:0006891;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;vesicle-mediated transport#GO:0016192;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG94372|UniProtKB=T1G906 T1G906 20217553 PTHR13586:SF0 SCD6 PROTEIN-RELATED TRAILER HITCH, ISOFORM H mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;P-body assembly#GO:0033962;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoplasmic stress granule assembly#GO:0034063 cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG109402|UniProtKB=T1EET4 T1EET4 20195086 PTHR43884:SF42 ACYL-COA DEHYDROGENASE SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;short-chain fatty acid catabolic process#GO:0019626;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;lipid modification#GO:0030258;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG173558|UniProtKB=T1F6Z1 T1F6Z1 20204590 PTHR11615:SF372 NITRATE, FORMATE, IRON DEHYDROGENASE CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR CG17683-RELATED iron-sulfur cluster assembly#GO:0016226;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG87714|UniProtKB=T1G6U7 T1G6U7 20216794 PTHR23147:SF22 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 membraneless organelle#GO:0043228;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG69964|UniProtKB=T1G006 T1G006 20214404 PTHR22811:SF50 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 2 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component organization#GO:0016043;Golgi organization#GO:0007030;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031 endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68730|UniProtKB=T1FZJ0 T1FZJ0 20214238 PTHR48041:SF78 ABC TRANSPORTER G FAMILY MEMBER 28 ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG86747|UniProtKB=T1G6G3 T1G6G3 20216660 PTHR31308:SF3 FAMILY NOT NAMED ENDOGLYCOCERAMIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;glucosidase activity#GO:0015926;beta-glucosidase activity#GO:0008422;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;metabolic process#GO:0008152;glycosyl compound catabolic process#GO:1901658 HELRO|EnsemblGenome=HelroG63970|UniProtKB=T1FXM9 T1FXM9 20213577 PTHR10356:SF0 ALLOGRAFT INFLAMMATORY FACTOR-1 CALCIUM-BINDING PROTEIN B cytoskeletal protein binding#GO:0008092;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;actin binding#GO:0003779;actin filament binding#GO:0051015;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;cation binding#GO:0043169 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;leading edge membrane#GO:0031256;intracellular organelle#GO:0043229;cell projection membrane#GO:0031253;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944;supramolecular complex#GO:0099080;plasma membrane region#GO:0098590;supramolecular polymer#GO:0099081;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;ruffle membrane#GO:0032587;cytoskeleton#GO:0005856;actin filament#GO:0005884;ruffle#GO:0001726;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG171835|UniProtKB=T1F4R8 T1F4R8 20203817 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170108|UniProtKB=T1F2M8 T1F2M8 20203077 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG121397|UniProtKB=T1EGR8 T1EGR8 20195768 PTHR11675:SF63 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG62058|UniProtKB=T1FWV0 T1FWV0 20213298 PTHR10590:SF24 SODIUM/NUCLEOSIDE COTRANSPORTER CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1-RELATED monoatomic ion transmembrane transporter activity#GO:0015075;nucleoside transmembrane transporter activity#GO:0005337;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;solute:sodium symporter activity#GO:0015370;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG156445|UniProtKB=T1ELW8 T1ELW8 20197568 PTHR43377:SF2 BILIVERDIN REDUCTASE A BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG84435|UniProtKB=T1G5I6 T1G5I6 20216333 PTHR14388:SF17 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG72426|UniProtKB=T1G0Z8 T1G0Z8 20214746 PTHR45752:SF215 LEUCINE-RICH REPEAT-CONTAINING GH17740P-RELATED signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156183|UniProtKB=T1ELS3 T1ELS3 20197523 PTHR23086:SF150 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG106279|UniProtKB=T1EE13 T1EE13 20194815 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HELRO|EnsemblGenome=HelroG164405|UniProtKB=T1EVD9 T1EVD9 20200539 PTHR46618:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 3 ARMADILLO REPEAT-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG156657|UniProtKB=T1ELZ4 T1ELZ4 20197594 PTHR15653:SF0 STRIATIN CONNECTOR OF KINASE TO AP-1, ISOFORM E molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG101626|UniProtKB=T1ED59 T1ED59 20194511 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG163760|UniProtKB=T1EUF6 T1EUF6 20200206 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;macromolecule catabolic process#GO:0009057;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;snRNA metabolic process#GO:0016073;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;nuclear mRNA surveillance#GO:0071028;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG109375|UniProtKB=T1EES9 T1EES9 20195081 PTHR45819:SF5 CENTAURIN-GAMMA-1A CENTAURIN-GAMMA-1A GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG63344|UniProtKB=T1FXE5 T1FXE5 20213493 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804 homeostatic process#GO:0042592;regulation of cytosolic calcium ion concentration#GO:0051480;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;calcium ion homeostasis#GO:0055074 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG176347|UniProtKB=T1FAE8 T1FAE8 20205797 PTHR13556:SF2 TRANSCRIPTIONAL ADAPTER 3-RELATED TRANSCRIPTIONAL ADAPTER 3 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;chromatin#GO:0000785;SAGA complex#GO:0000124;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG65843|UniProtKB=T1FYD4 T1FYD4 20213832 PTHR13163:SF2 SPINAL CORD EXPRESSION PROTEIN 4 TRANSMEMBRANE PROTEIN 35B cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;biological regulation#GO:0065007;cellular component assembly#GO:0022607;chaperone-mediated protein complex assembly#GO:0051131;protein-containing complex organization#GO:0043933;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG86528|UniProtKB=T1G6D5 T1G6D5 20216632 PTHR16515:SF88 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185894|UniProtKB=T1FNE7 T1FNE7 20210344 PTHR16002:SF4 TRANSMEMBRANE PROTEIN 248-LIKE TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191344|UniProtKB=T1FSW8 T1FSW8 20211915 PTHR11243:SF39 GROWTH FACTOR RECEPTOR-BOUND PROTEIN LD06925P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;regulation of cellular process#GO:0050794 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG97247|UniProtKB=T1G9G2 T1G9G2 20217709 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG152267|UniProtKB=T1EKQ3 T1EKQ3 20197153 PTHR31195:SF2 GEO02494P1 GEO02494P1 HELRO|EnsemblGenome=HelroG153976|UniProtKB=T1ELD4 T1ELD4 20197384 PTHR43083:SF6 MANNAN POLYMERASE II MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9 mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;cell wall macromolecule biosynthetic process#GO:0044038;cellular component biogenesis#GO:0044085;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;cell wall organization or biogenesis#GO:0071554;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;cell wall macromolecule metabolic process#GO:0044036;protein metabolic process#GO:0019538;cell wall biogenesis#GO:0042546 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;transferase complex#GO:1990234;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;mannosyltransferase complex#GO:0031501;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi cisterna#GO:0031985;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG185601|UniProtKB=T1FN09 T1FN09 20210208 PTHR45625:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2 peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;cis-trans isomerase activity#GO:0016859;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG192564|UniProtKB=T1FU31 T1FU31 20212327 PTHR10139:SF9 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle G2/M phase transition#GO:1902750;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;negative regulation of mitotic cell cycle phase transition#GO:1901991;organelle organization#GO:0006996;meiotic DNA double-strand break formation#GO:0042138;signal transduction#GO:0007165;cellular process#GO:0009987;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;biological regulation#GO:0065007;regulation of G2/M transition of mitotic cell cycle#GO:0010389;telomere organization#GO:0032200;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA recombination#GO:0006310;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;cellular response to stress#GO:0033554;signaling#GO:0023052;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;double-strand break repair via nonhomologous end joining#GO:0006303;telomere maintenance#GO:0000723;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;mitotic cell cycle checkpoint signaling#GO:0007093;nucleic acid metabolic process#GO:0090304;mitotic DNA damage checkpoint signaling#GO:0044773 site of double-strand break#GO:0035861;chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183321|UniProtKB=T1FJG3 T1FJG3 20208962 PTHR21847:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cilium movement#GO:0003341;cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;radial spoke#GO:0001534;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;cilium#GO:0005929;intracellular organelle#GO:0043229;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG166445|UniProtKB=T1EY53 T1EY53 20201503 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG194913|UniProtKB=T1FWK2 T1FWK2 20213197 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG81531|UniProtKB=T1G4F4 T1G4F4 20215952 PTHR10797:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;CCR4-NOT complex#GO:0030014;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189707|UniProtKB=T1FRA2 T1FRA2 20211349 PTHR24418:SF463 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;non-membrane spanning protein tyrosine kinase activity#GO:0004715;signaling receptor binding#GO:0005102;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713 regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular developmental process#GO:0048869;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG90119|UniProtKB=T1G7L3 T1G7L3 20217060 PTHR22734:SF2 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG165371|UniProtKB=T1EWN6 T1EWN6 20200986 PTHR33395:SF24 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165143|UniProtKB=T1EWC3 T1EWC3 20200873 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192253|UniProtKB=T1FTR6 T1FTR6 20212213 PTHR11289:SF0 BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2 BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;double-strand break repair#GO:0006302;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009;damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG87802|UniProtKB=T1G6V6 T1G6V6 20216803 PTHR10146:SF18 PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167 cellular process#GO:0009987;pyridine-containing compound metabolic process#GO:0072524;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG146448|UniProtKB=T1EJS3 T1EJS3 20196823 PTHR15561:SF0 CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase III#GO:0006383;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG186005|UniProtKB=T1FNJ4 T1FNJ4 20210391 PTHR24012:SF918 RNA BINDING PROTEIN RRM DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143 post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81586|UniProtKB=T1G4G0 T1G4G0 20215958 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94403|UniProtKB=T1G908 T1G908 20217555 PTHR21705:SF11 RAI16 PROTEIN-RELATED FHIP FAMILY PROTEIN CG3558 HELRO|EnsemblGenome=HelroG83126|UniProtKB=T1G506 T1G506 20216154 PTHR12450:SF14 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 GLYCOSAMINOGLYCAN XYLOSYLKINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180623|UniProtKB=T1FG36 T1FG36 20207785 PTHR14043:SF18 CCAAT DISPLACEMENT PROTEIN-RELATED HOMEOBOX PROTEIN CUT sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG67495|UniProtKB=T1FZ18 T1FZ18 20214066 PTHR24208:SF105 LIM/HOMEOBOX PROTEIN LHX DLIM1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG189443|UniProtKB=T1FR24 T1FR24 20211271 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG167884|UniProtKB=T1EZX2 T1EZX2 20202122 PTHR15545:SF8 PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4 SLO-INTERACTING PROTEIN 1 HELRO|EnsemblGenome=HelroG195098|UniProtKB=T1FWQ9 T1FWQ9 20213254 PTHR12544:SF52 GLUTAMINASE GLUTAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG121421|UniProtKB=T1EGR9 T1EGR9 20195769 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N(6)-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT METTL3 methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 RNA modification#GO:0009451;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;cellular process#GO:0009987;mRNA modification#GO:0016556;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;nucleobase-containing compound metabolic process#GO:0006139 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG112954|UniProtKB=T1EFN5 T1EFN5 20195387 PTHR11629:SF114 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;enzyme binding#GO:0019899;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;binding#GO:0005488 regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655 intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG132019|UniProtKB=T1EHX1 T1EHX1 20196171 PTHR24056:SF189 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE cyclin binding#GO:0030332;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG113751|UniProtKB=T1EFV9 T1EFV9 20195461 PTHR45674:SF20 DNA LIGASE 1/3 FAMILY MEMBER DNA LIGASE 3 catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009;DNA ligase#PC00012 HELRO|EnsemblGenome=HelroG182232|UniProtKB=T1FHY9 T1FHY9 20208438 PTHR31606:SF1 WW DOMAIN BINDING PROTEIN 2, ISOFORM E WW DOMAIN BINDING PROTEIN 2, ISOFORM E DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG167179|UniProtKB=T1EZ38 T1EZ38 20201838 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG185657|UniProtKB=T1FN35 T1FN35 20210233 PTHR43028:SF4 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 INOSITOL MONOPHOSPHATASE 3-RELATED hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG184008|UniProtKB=T1FKE9 T1FKE9 20209298 PTHR10398:SF2 AFADIN AFADIN cytoskeletal adaptor activity#GO:0008093;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 adherens junction organization#GO:0034332;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell junction organization#GO:0034330;cell adhesion#GO:0007155;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cell-cell junction maintenance#GO:0045217 cell junction#GO:0030054;adherens junction#GO:0005912;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell-cell junction#GO:0005911;cell cortex#GO:0005938;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 Alzheimer disease-presenilin pathway#P00004>Afadin#P00146 HELRO|EnsemblGenome=HelroG114036|UniProtKB=T1EFY4 T1EFY4 20195486 PTHR43636:SF2 ELONGATION FACTOR G, MITOCHONDRIAL ELONGATION FACTOR G, MITOCHONDRIAL hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 translation#GO:0006412;metabolic process#GO:0008152;translational elongation#GO:0006414;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG85008|UniProtKB=T1G5R3 T1G5R3 20216410 PTHR11049:SF24 ACYL COENZYME A THIOESTER HYDROLASE CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE hydrolase activity#GO:0016787;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;deacylase activity#GO:0160215;acyl-CoA hydrolase activity#GO:0016289;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 esterase#PC00097 HELRO|EnsemblGenome=HelroG84081|UniProtKB=T1G5E4 T1G5E4 20216291 PTHR11803:SF64 2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA REACTIVE INTERMEDIATE IMINE DEAMINASE A HOMOLOG deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of protein metabolic process#GO:0051246;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;deaminase#PC00088;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG173658|UniProtKB=T1F732 T1F732 20204631 PTHR11339:SF395 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED MUCIN-2 ISOFORM X1 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG83132|UniProtKB=T1G508 T1G508 20216156 PTHR12375:SF30 RNA-BINDING PROTEIN LUC7-RELATED RNA-BINDING PROTEIN ALSIN2-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA splice site recognition#GO:0006376;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2-type prespliceosome#GO:0071004;spliceosomal complex#GO:0005681 HELRO|EnsemblGenome=HelroG158631|UniProtKB=T1EN16 T1EN16 20197966 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157814|UniProtKB=T1EMG3 T1EMG3 20197763 PTHR13399:SF2 TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160565|UniProtKB=T1EQF3 T1EQF3 20198803 PTHR10694:SF148 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213;protein demethylase activity#GO:0140457;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;demethylase activity#GO:0032451;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG193988|UniProtKB=T1FVJ7 T1FVJ7 20212843 PTHR31516:SF22 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;sperm flagellum#GO:0036126;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;microtubule#GO:0005874;axoneme#GO:0005930;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic microtubule#GO:0005881;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG186115|UniProtKB=T1FNP0 T1FNP0 20210437 PTHR12234:SF0 FORMIMINOTRANSFERASE-CYCLODEAMINASE FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;lyase activity#GO:0016829 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG194446|UniProtKB=T1FW24 T1FW24 20213020 PTHR22855:SF13 ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG191101|UniProtKB=T1FSL2 T1FSL2 20211809 PTHR14963:SF7 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 19 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG104986|UniProtKB=T1EDP6 T1EDP6 20194698 PTHR11740:SF0 CASEIN KINASE II SUBUNIT BETA CASEIN KINASE II SUBUNIT BETA-RELATED enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Parkinson disease#P00049>Casein kinase II#P01236;Wnt signaling pathway#P00057>Casein Kinase 2#P01459;Cadherin signaling pathway#P00012>Casein kinase II#P00462 HELRO|EnsemblGenome=HelroG167889|UniProtKB=T1EZX4 T1EZX4 20202124 PTHR14735:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 134 COILED-COIL DOMAIN-CONTAINING PROTEIN 134 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178470|UniProtKB=T1FD78 T1FD78 20206777 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG179807|UniProtKB=T1FF63 T1FF63 20207462 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG185327|UniProtKB=T1FMP1 T1FMP1 20210090 PTHR11627:SF80 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;aldehyde-lyase activity#GO:0016832;fructose-bisphosphate aldolase activity#GO:0004332;lyase activity#GO:0016829 carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine-containing compound catabolic process#GO:0072523;ADP catabolic process#GO:0046032;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nicotinamide nucleotide metabolic process#GO:0046496;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;primary metabolic process#GO:0044238;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 lyase#PC00144;aldolase#PC00044 Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959;Glycolysis#P00024>Aldolase#P00679 HELRO|EnsemblGenome=HelroG174542|UniProtKB=T1F886 T1F886 20205035 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG162988|UniProtKB=T1ETI0 T1ETI0 20199880 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168939|UniProtKB=T1F159 T1F159 20202559 PTHR11991:SF23 TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;negative regulation of cell communication#GO:0010648;negative regulation of catabolic process#GO:0009895;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of signaling#GO:0023057 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG78406|UniProtKB=T1G3B5 T1G3B5 20215563 PTHR12377:SF2 CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178767|UniProtKB=T1FDP6 T1FDP6 20206945 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172902|UniProtKB=T1F637 T1F637 20204286 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG85855|UniProtKB=T1G635 T1G635 20216532 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG148427|UniProtKB=T1EK82 T1EK82 20196982 PTHR23050:SF558 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 6 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG172475|UniProtKB=T1F5D3 T1F5D3 20204032 PTHR46685:SF1 28S RIBOSOMAL PROTEIN S15, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN US15M mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG70975|UniProtKB=T1G0F2 T1G0F2 20214550 PTHR12755:SF6 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG172548|UniProtKB=T1F5H9 T1F5H9 20204078 PTHR36193:SF24 PHISTB DOMAIN-CONTAINING RESA-LIKE PROTEIN 1 SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG111789|UniProtKB=T1EFE6 T1EFE6 20195298 PTHR11055:SF79 BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE PAPS SYNTHETASE, ISOFORM D phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137 Sulfate assimilation#P02778>Sulfate adenylyltransferase#P03167 HELRO|EnsemblGenome=HelroG177743|UniProtKB=T1FC63 T1FC63 20206412 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187888|UniProtKB=T1FPG2 T1FPG2 20210709 PTHR47096:SF1 MISSHAPEN LIKE KINASE 1 NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG78642|UniProtKB=T1G3E0 T1G3E0 20215588 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 molecular sensor activity#GO:0140299;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of exocytosis#GO:0017157;secretion#GO:0046903;regulation of secretion#GO:0051046;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;neurotransmitter transport#GO:0006836;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;synaptic signaling#GO:0099536;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;regulation of transport#GO:0051049;regulation of localization#GO:0032879;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;export from cell#GO:0140352;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of neurotransmitter transport#GO:0051588 cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;organelle membrane#GO:0031090;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;axon#GO:0030424;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;intracellular vesicle#GO:0097708;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG102862|UniProtKB=T1EDC5 T1EDC5 20194577 PTHR14190:SF16 SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 localization within membrane#GO:0051668;lysosomal transport#GO:0007041;cellular localization#GO:0051641;localization#GO:0051179;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG80450|UniProtKB=T1G408 T1G408 20215806 PTHR10574:SF365 NETRIN/LAMININ-RELATED NETRIN-A-RELATED developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon development#GO:0061564;axon guidance#GO:0007411;tissue development#GO:0009888;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;anatomical structure development#GO:0048856;system development#GO:0048731;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;dendrite development#GO:0016358;axonogenesis#GO:0007409;neuron development#GO:0048666;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468 extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HELRO|EnsemblGenome=HelroG172738|UniProtKB=T1F5W2 T1F5W2 20204211 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189878|UniProtKB=T1FRG1 T1FRG1 20211408 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG96778|UniProtKB=T1G9D7 T1G9D7 20217684 PTHR18952:SF278 CARBONIC ANHYDRASE CARBONIC ANHYDRASE hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG125222|UniProtKB=T1EH51 T1EH51 20195901 PTHR11232:SF57 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER RE46159P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77913|UniProtKB=T1G354 T1G354 20215502 PTHR45787:SF1 LD11652P BEADEX, ISOFORM D transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG185683|UniProtKB=T1FN52 T1FN52 20210250 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192230|UniProtKB=T1FTQ9 T1FTQ9 20212206 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG171419|UniProtKB=T1F493 T1F493 20203642 PTHR23359:SF243 NUCLEOTIDE KINASE ADENYLATE KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137;nucleotide kinase#PC00172 HELRO|EnsemblGenome=HelroG191089|UniProtKB=T1FSK9 T1FSK9 20211806 PTHR10083:SF390 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED PAPILIN enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG124246|UniProtKB=T1EH05 T1EH05 20195855 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 6 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG168910|UniProtKB=T1F144 T1F144 20202544 PTHR15818:SF2 G PATCH AND KOW-CONTAINING G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG162671|UniProtKB=T1ET00 T1ET00 20199700 PTHR24244:SF1 NEUROPEPTIDE S RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG162653|UniProtKB=T1ESZ0 T1ESZ0 20199690 PTHR23068:SF25 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM1 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA methyltransferase#PC00013 HELRO|EnsemblGenome=HelroG188930|UniProtKB=T1FQH7 T1FQH7 20211074 PTHR31057:SF0 E3 UFM1-PROTEIN LIGASE 1 E3 UFM1-PROTEIN LIGASE 1 ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macroautophagy#GO:0016236;response to stimulus#GO:0050896;catabolic process#GO:0009056;autophagy#GO:0006914;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;reticulophagy#GO:0061709;response to stress#GO:0006950;process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG176405|UniProtKB=T1FAH6 T1FAH6 20205825 PTHR31159:SF1 COMM DOMAIN-CONTAINING PROTEIN 3 COMM DOMAIN-CONTAINING PROTEIN 3 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG77257|UniProtKB=T1G2V1 T1G2V1 20215399 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG183160|UniProtKB=T1FJ85 T1FJ85 20208884 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194635|UniProtKB=T1FW93 T1FW93 20213089 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG115304|UniProtKB=T1EG74 T1EG74 20195576 PTHR23123:SF35 PHD/F-BOX CONTAINING PROTEIN F-BOX_LRR-REPEAT PROTEIN 19 protein-macromolecule adaptor activity#GO:0030674;histone modifying activity#GO:0140993;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;molecular adaptor activity#GO:0060090;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457 proteasomal protein catabolic process#GO:0010498;chromatin organization#GO:0006325;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;catabolic process#GO:0009056;chromatin remodeling#GO:0006338;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG191914|UniProtKB=T1FTE9 T1FTE9 20212096 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG191481|UniProtKB=T1FT09 T1FT09 20211956 PTHR16199:SF4 CONDENSIN-2 COMPLEX SUBUNIT G2 CONDENSIN-2 COMPLEX SUBUNIT G2 chromosome segregation#GO:0007059;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;nuclear division#GO:0000280;organelle fission#GO:0048285;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;mitotic cell cycle#GO:0000278 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;condensin complex#GO:0000796 HELRO|EnsemblGenome=HelroG159064|UniProtKB=T1ENJ7 T1ENJ7 20198147 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG185544|UniProtKB=T1FMY7 T1FMY7 20210186 PTHR15430:SF1 GLOMULIN RE73310P enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of proteasomal protein catabolic process#GO:0061136;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of catabolic process#GO:0009894;regulation of protein catabolic process#GO:0042176 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185861|UniProtKB=T1FND2 T1FND2 20210329 PTHR14063:SF10 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of synapse assembly#GO:0051963;vesicle localization#GO:0051648;establishment of localization#GO:0051234;transport#GO:0006810;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of growth#GO:0040008;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of synapse structure or activity#GO:0050803;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;regulation of cell junction assembly#GO:1901888;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;signal release#GO:0023061;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836;synaptic vesicle localization#GO:0097479;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;synaptic signaling#GO:0099536;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;export from cell#GO:0140352;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;cellular localization#GO:0051641;regulation of synapse organization#GO:0050807 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell junction#GO:0030054 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG194502|UniProtKB=T1FW47 T1FW47 20213043 PTHR19282:SF452 TETRASPANIN LD03691P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185473|UniProtKB=T1FMV1 T1FMV1 20210150 PTHR43313:SF50 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C RETINOL DEHYDROGENASE 7 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG77693|UniProtKB=T1G324 T1G324 20215472 PTHR13271:SF165 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE MIP03820P histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG195104|UniProtKB=T1FWR3 T1FWR3 20213258 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG76198|UniProtKB=T1G2G7 T1G2G7 20215265 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 32 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TLR#P01346 HELRO|EnsemblGenome=HelroG170590|UniProtKB=T1F378 T1F378 20203277 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG163054|UniProtKB=T1ETL9 T1ETL9 20199919 PTHR23092:SF15 POLY(A) RNA POLYMERASE INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740 RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG116949|UniProtKB=T1EGI6 T1EGI6 20195688 PTHR19969:SF5 SH2-SH3 ADAPTOR PROTEIN-RELATED ADAPTER MOLECULE CRK receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591;protein binding#GO:0005515 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Crk#P00207 HELRO|EnsemblGenome=HelroG167838|UniProtKB=T1EZV1 T1EZV1 20202101 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159338|UniProtKB=T1ENW8 T1ENW8 20198268 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160566|UniProtKB=T1EQF4 T1EQF4 20198804 PTHR21258:SF56 DOCKING PROTEIN RELATED IRS-TYPE PTB DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169949|UniProtKB=T1F2G9 T1F2G9 20203019 PTHR12352:SF30 SECRETED MODULAR CALCIUM-BINDING PROTEIN FI05255P heparin binding#GO:0008201;glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;extracellular matrix binding#GO:0050840 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG160537|UniProtKB=T1EQD8 T1EQD8 20198788 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG88258|UniProtKB=T1G708 T1G708 20216855 PTHR14519:SF5 VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1 VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1-LIKE PROTEIN 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 ketone metabolic process#GO:0042180;vitamin K metabolic process#GO:0042373;metabolic process#GO:0008152;cellular process#GO:0009987 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192192|UniProtKB=T1FTP1 T1FTP1 20212188 PTHR46004:SF3 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HELRO|EnsemblGenome=HelroG180031|UniProtKB=T1FFD2 T1FFD2 20207531 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192217|UniProtKB=T1FTQ1 T1FTQ1 20212198 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;protein binding#GO:0005515 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194546|UniProtKB=T1FW65 T1FW65 20213061 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN EXPRESSED PROTEIN O-methyltransferase activity#GO:0008171;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG170438|UniProtKB=T1F325 T1F325 20203224 PTHR45781:SF1 AGAP000281-PA HMG BOX DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG74357|UniProtKB=T1G1Q0 T1G1Q0 20214998 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS HOMEOTIC PROTEIN FEMALE STERILE-RELATED chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG142891|UniProtKB=T1EJ81 T1EJ81 20196631 PTHR23226:SF139 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER X-CHROMOSOMAL PROTEIN DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG165465|UniProtKB=T1EWU6 T1EWU6 20201046 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179287|UniProtKB=T1FEH5 T1FEH5 20207224 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89777|UniProtKB=T1G7H5 T1G7H5 20217022 PTHR10182:SF3 CALCIUM-BINDING PROTEIN 39-RELATED PROTEIN MO25 kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 HELRO|EnsemblGenome=HelroG171575|UniProtKB=T1F4F0 T1F4F0 20203699 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION HDC11342-RELATED regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;regulation of spindle organization#GO:0090224;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of microtubule-based process#GO:0032886;regulation of spindle assembly#GO:0090169;regulation of mitotic spindle organization#GO:0060236;regulation of organelle assembly#GO:1902115;regulation of mitotic cell cycle#GO:0007346;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of mitotic spindle assembly#GO:1901673 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG182830|UniProtKB=T1FIT7 T1FIT7 20208736 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG90258|UniProtKB=T1G7N5 T1G7N5 20217082 PTHR31501:SF7 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 ion channel#PC00133 HELRO|EnsemblGenome=HelroG167670|UniProtKB=T1EZN2 T1EZN2 20202032 PTHR16501:SF6 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 HELRO|EnsemblGenome=HelroG166196|UniProtKB=T1EXW1 T1EXW1 20201411 PTHR14196:SF0 ODD-SKIPPED - RELATED PROTEIN ODD-SKIPPED-RELATED 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 pattern specification process#GO:0007389;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG177723|UniProtKB=T1FC48 T1FC48 20206397 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194117|UniProtKB=T1FVP9 T1FVP9 20212895 PTHR13900:SF0 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 protein binding#GO:0005515;binding#GO:0005488;transcription factor binding#GO:0008134 cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG75473|UniProtKB=T1G255 T1G255 20215153 PTHR10972:SF215 OXYSTEROL-BINDING PROTEIN-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3-LIKE PROTEIN binding#GO:0005488;sterol binding#GO:0032934;lipid binding#GO:0008289;steroid binding#GO:0005496 membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG164538|UniProtKB=T1EVK0 T1EVK0 20200600 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN SHIFTED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG66947|UniProtKB=T1FYT7 T1FYT7 20213985 PTHR12992:SF48 NUDIX HYDROLASE PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound catabolic process#GO:0044273;purine-containing compound catabolic process#GO:0072523;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;organophosphate catabolic process#GO:0046434 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG74696|UniProtKB=T1G1U5 T1G1U5 20215043 PTHR11616:SF341 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT DOPAMINE TRANSPORTER symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoamine transmembrane transporter activity#GO:0008504;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804 trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;organic hydroxy compound transport#GO:0015850;transmembrane transport#GO:0055085;cellular localization#GO:0051641;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;amino acid transport#GO:0006865;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;synaptic transmission, dopaminergic#GO:0001963;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;sodium ion transmembrane transport#GO:0035725;synaptic signaling#GO:0099536;nitrogen compound transport#GO:0071705;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;neurotransmitter transport#GO:0006836;monoatomic cation transmembrane transport#GO:0098655;cell-cell signaling#GO:0007267 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;presynapse#GO:0098793;membrane#GO:0016020;presynaptic membrane#GO:0042734;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;axon#GO:0030424;cell body#GO:0044297;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;synapse#GO:0045202;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG187921|UniProtKB=T1FPH1 T1FPH1 20210718 PTHR16650:SF6 C21ORF13-RELATED GH21622P microtubule-based transport#GO:0099111;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705 cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG152303|UniProtKB=T1EKQ6 T1EKQ6 20197156 PTHR12962:SF1 CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA stability#GO:0043488;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of biological quality#GO:0065008;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG65081|UniProtKB=T1FY31 T1FY31 20213729 PTHR16222:SF44 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 catalytic activity#GO:0003824;hydrolase activity#GO:0016787 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG180432|UniProtKB=T1FFX0 T1FFX0 20207719 PTHR12894:SF51 CNH DOMAIN CONTAINING TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1 transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;cellular component organization#GO:0016043;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;vesicle fusion#GO:0006906;membrane organization#GO:0061024 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG64618|UniProtKB=T1FXX2 T1FXX2 20213670 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182825|UniProtKB=T1FIT4 T1FIT4 20208733 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG179637|UniProtKB=T1FEY9 T1FEY9 20207388 PTHR10912:SF7 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cyclase#PC00079;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG66676|UniProtKB=T1FYN8 T1FYN8 20213936 PTHR21229:SF2 LUNG SEVEN TRANSMEMBRANE RECEPTOR RE59932P membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG163489|UniProtKB=T1EU44 T1EU44 20200094 PTHR19307:SF14 TUMOR PROTEIN D52 TUMOR PROTEIN D52 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG179256|UniProtKB=T1FEF8 T1FEF8 20207207 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164658|UniProtKB=T1EVP4 T1EVP4 20200644 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HELRO|EnsemblGenome=HelroG159708|UniProtKB=T1EPC0 T1EPC0 20198420 PTHR11941:SF27 ENOYL-COA HYDRATASE-RELATED ETHYLMALONYL-COA DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;hydratase#PC00120;lyase#PC00144 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG67318|UniProtKB=T1FYZ5 T1FYZ5 20214043 PTHR11009:SF1 DER1-LIKE PROTEIN, DERLIN DERLIN-1 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG86213|UniProtKB=T1G686 T1G686 20216583 PTHR22984:SF33 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE 1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;regulation of mitotic cell cycle#GO:0007346;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG84308|UniProtKB=T1G5H4 T1G5H4 20216321 PTHR13140:SF709 MYOSIN UNCONVENTIONAL MYOSIN-XV cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657 supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG185631|UniProtKB=T1FN25 T1FN25 20210224 PTHR43503:SF4 MCG48959-RELATED PEROXIREDOXIN-6 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;catalytic activity#GO:0003824;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209 cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG178226|UniProtKB=T1FCY7 T1FCY7 20206686 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG140562|UniProtKB=T1EJ14 T1EJ14 20196564 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG180527|UniProtKB=T1FG07 T1FG07 20207756 PTHR21444:SF14 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 HELRO|EnsemblGenome=HelroG189594|UniProtKB=T1FR66 T1FR66 20211313 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184869|UniProtKB=T1FM37 T1FM37 20209886 PTHR11239:SF12 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription termination#GO:0006353;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG114071|UniProtKB=T1EFY7 T1EFY7 20195489 PTHR21650:SF4 MEMBRALIN/KINETOCHORE PROTEIN NUF2 MEMBRALIN regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of cellular response to stress#GO:0080135;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of metabolic process#GO:0009893;cellular response to stress#GO:0033554;positive regulation of protein metabolic process#GO:0051247;response to endoplasmic reticulum stress#GO:0034976;regulation of ERAD pathway#GO:1904292;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of response to endoplasmic reticulum stress#GO:1905897;positive regulation of proteasomal protein catabolic process#GO:1901800 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188121|UniProtKB=T1FPN8 T1FPN8 20210785 PTHR45080:SF48 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 axon#GO:0030424;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;cell body#GO:0044297 HELRO|EnsemblGenome=HelroG164856|UniProtKB=T1EVW3 T1EVW3 20200713 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG178978|UniProtKB=T1FE00 T1FE00 20207049 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93454|UniProtKB=T1G8V9 T1G8V9 20217506 PTHR10969:SF4 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289 cellular response to stress#GO:0033554;organelle assembly#GO:0070925;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;cellular component disassembly#GO:0022411;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to nutrient levels#GO:0031669;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to nutrient levels#GO:0031667;response to stress#GO:0006950;macroautophagy#GO:0016236;cellular component assembly#GO:0022607 vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane#GO:0016020 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG174407|UniProtKB=T1F834 T1F834 20204983 PTHR34396:SF25 OS03G0264950 PROTEIN-RELATED BOUNDARY ELEMENT ASSOCIATED FACTOR regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG105051|UniProtKB=T1EDQ1 T1EDQ1 20194703 PTHR13208:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84767|UniProtKB=T1G5N5 T1G5N5 20216382 PTHR45827:SF1 SORTING NEXIN SORTING NEXIN ion binding#GO:0043167;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;binding#GO:0005488 transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;plasma membrane organization#GO:0007009;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;endocytosis#GO:0006897 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184328|UniProtKB=T1FL04 T1FL04 20209503 PTHR12619:SF35 RFX TRANSCRIPTION FACTOR FAMILY TRANSCRIPTION FACTOR RFX4 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG78591|UniProtKB=T1G3D5 T1G3D5 20215583 PTHR12782:SF5 MICROSOMAL PROSTAGLANDIN E SYNTHASE-2 PROSTAGLANDIN E SYNTHASE 2 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 oxidoreductase#PC00176;reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160028|UniProtKB=T1EPP1 T1EPP1 20198541 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG186523|UniProtKB=T1FP04 T1FP04 20210551 PTHR10906:SF1 SECY/SEC61-ALPHA FAMILY MEMBER DSEC61ALPHA ribonucleoprotein complex binding#GO:0043021;transmembrane protein transporter activity#GO:0008320;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 protein transport#GO:0015031;post-translational protein targeting to membrane, translocation#GO:0031204;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting#GO:0006605;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting to ER#GO:0045047;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein targeting to membrane#GO:0006612;establishment of protein localization to endoplasmic reticulum#GO:0072599;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;rough endoplasmic reticulum membrane#GO:0030867;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;rough endoplasmic reticulum#GO:0005791;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 transporter#PC00227 HELRO|EnsemblGenome=HelroG179248|UniProtKB=T1FEF5 T1FEF5 20207204 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168576|UniProtKB=T1F0R2 T1F0R2 20202412 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG90491|UniProtKB=T1G7S1 T1G7S1 20217118 PTHR46314:SF2 SOLUTE CARRIER FAMILY 25 MEMBER 44 SOLUTE CARRIER FAMILY 25 MEMBER 44 branched-chain amino acid transmembrane transporter activity#GO:0015658;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215 organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;nitrogen compound transport#GO:0071705;branched-chain amino acid transport#GO:0015803;localization#GO:0051179;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG114057|UniProtKB=T1EFY5 T1EFY5 20195487 PTHR23077:SF117 AAA-FAMILY ATPASE ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG152396|UniProtKB=T1EKR3 T1EKR3 20197163 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG172590|UniProtKB=T1F5K4 T1F5K4 20204103 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189525|UniProtKB=T1FR47 T1FR47 20211294 PTHR14396:SF10 CLASPIN CLASPIN HELRO|EnsemblGenome=HelroG165477|UniProtKB=T1EWV7 T1EWV7 20201057 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193855|UniProtKB=T1FVF1 T1FVF1 20212797 PTHR13407:SF0 RNF121 PROTEIN FI05221P ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG90393|UniProtKB=T1G7Q6 T1G7Q6 20217103 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG171971|UniProtKB=T1F4W7 T1F4W7 20203866 PTHR17985:SF28 SER/THR-RICH PROTEIN T10 IN DGCR REGION TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;establishment of protein localization to extracellular region#GO:0035592;transport#GO:0006810;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein secretion#GO:0009306;localization#GO:0051179;secretion#GO:0046903;secretion by cell#GO:0032940;protein transport#GO:0015031;export from cell#GO:0140352;cellular component organization#GO:0016043;Golgi organization#GO:0007030;protein localization to extracellular region#GO:0071692 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG182613|UniProtKB=T1FIH3 T1FIH3 20208622 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG78719|UniProtKB=T1G3E9 T1G3E9 20215597 PTHR23023:SF266 DIMETHYLANILINE MONOOXYGENASE FLAVIN-CONTAINING MONOOXYGENASE oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG186024|UniProtKB=T1FNK1 T1FNK1 20210398 PTHR23359:SF70 NUCLEOTIDE KINASE ADENYLATE KINASE ISOENZYME 1 transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG174042|UniProtKB=T1F7I7 T1F7I7 20204786 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG145054|UniProtKB=T1EJI3 T1EJI3 20196733 PTHR10071:SF340 TRANSCRIPTION FACTOR GATA FAMILY MEMBER FI19405P1-RELATED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cell fate commitment#GO:0045165;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG71911|UniProtKB=T1G0T0 T1G0T0 20214678 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG169037|UniProtKB=T1F1A5 T1F1A5 20202605 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116356|UniProtKB=T1EGE2 T1EGE2 20195644 PTHR23226:SF416 ZINC FINGER AND SCAN DOMAIN-CONTAINING CROL ALPHA-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG107657|UniProtKB=T1EEC0 T1EEC0 20194922 PTHR12483:SF115 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;copper ion transmembrane transport#GO:0035434;monoatomic cation transmembrane transport#GO:0098655;transition metal ion transport#GO:0000041;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG115835|UniProtKB=T1EGB1 T1EGB1 20195613 PTHR10174:SF130 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE phosphatidylinositol bisphosphate binding#GO:1902936;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG114577|UniProtKB=T1EG32 T1EG32 20195534 PTHR35250:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 4 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 5 HELRO|EnsemblGenome=HelroG158566|UniProtKB=T1EMY3 T1EMY3 20197933 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83456|UniProtKB=T1G558 T1G558 20216206 PTHR19444:SF13 UNC-93 RELATED N-ACETYLGLUCOSAMINE TRANSPORTER UNC93A molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG85564|UniProtKB=T1G5Z4 T1G5Z4 20216491 PTHR10264:SF137 BAND 7 PROTEIN-RELATED GH04404P1 transporter regulator activity#GO:0141108;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG183953|UniProtKB=T1FKC4 T1FKC4 20209273 PTHR48625:SF1 C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED C3H1-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156416|UniProtKB=T1ELV9 T1ELV9 20197559 PTHR14564:SF4 MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER MICOS COMPLEX SUBUNIT organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG194633|UniProtKB=T1FW91 T1FW91 20213087 PTHR22878:SF67 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED AAA+ ATPASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90313|UniProtKB=T1G7P2 T1G7P2 20217089 PTHR20884:SF8 GDP-D-GLUCOSE PHOSPHORYLASE 1 GDP-D-GLUCOSE PHOSPHORYLASE 1 nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 carbohydrate metabolic process#GO:0005975;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;response to stress#GO:0006950;glucose metabolic process#GO:0006006;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG73260|UniProtKB=T1G1C2 T1G1C2 20214870 PTHR10954:SF7 RIBONUCLEASE H2 SUBUNIT A RIBONUCLEASE H2 SUBUNIT A endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;mismatch repair#GO:0006298;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 endoribonuclease#PC00094 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG159777|UniProtKB=T1EPE3 T1EPE3 20198443 PTHR46025:SF3 XYLOSYLTRANSFERASE OXT XYLOSYLTRANSFERASE OXT transferase#PC00220 HELRO|EnsemblGenome=HelroG192405|UniProtKB=T1FTX1 T1FTX1 20212268 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG103935|UniProtKB=T1EDI7 T1EDI7 20194639 PTHR22974:SF23 MIXED LINEAGE PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;chromosome segregation#GO:0007059 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG155708|UniProtKB=T1ELL2 T1ELL2 20197462 PTHR45820:SF10 FI23527P1 ZINC TRANSPORTER 63C, ISOFORM F monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion homeostasis#GO:0050801;detoxification of inorganic compound#GO:0061687;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;detoxification#GO:0098754;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;response to metal ion#GO:0010038;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG81078|UniProtKB=T1G487 T1G487 20215885 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG155967|UniProtKB=T1ELQ1 T1ELQ1 20197501 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085;tubulin#PC00228 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HELRO|EnsemblGenome=HelroG185958|UniProtKB=T1FNH6 T1FNH6 20210373 PTHR24056:SF334 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 1 catalytic activity, acting on a protein#GO:0140096;histone kinase activity#GO:0035173;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674 negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;regulation of cell cycle process#GO:0010564;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;cellular process#GO:0009987;cell cycle G2/M phase transition#GO:0044839;signal transduction#GO:0007165;response to stress#GO:0006950;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stress#GO:0033554;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;mitotic cell cycle process#GO:1903047;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic cell cycle phase transition#GO:0044772;G2/M transition of mitotic cell cycle#GO:0000086;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>Cdc2#P04634 HELRO|EnsemblGenome=HelroG161920|UniProtKB=T1ES16 T1ES16 20199366 PTHR38537:SF13 JITTERBUG, ISOFORM N JITTERBUG, ISOFORM N HELRO|EnsemblGenome=HelroG65850|UniProtKB=T1FYD6 T1FYD6 20213834 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191283|UniProtKB=T1FSU3 T1FSU3 20211890 PTHR11346:SF147 GALECTIN GALECTIN carbohydrate binding#GO:0030246;binding#GO:0005488 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG116302|UniProtKB=T1EGE1 T1EGE1 20195643 PTHR12106:SF23 SORTILIN RELATED SORTILIN cytosolic transport#GO:0016482;endocytosis#GO:0006897;Golgi to endosome transport#GO:0006895;cellular component organization#GO:0016043;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle organization#GO:0016050;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194249|UniProtKB=T1FVU9 T1FVU9 20212945 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stress#GO:0006950;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG179612|UniProtKB=T1FEX8 T1FEX8 20207377 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN SHIFTED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG64166|UniProtKB=T1FXQ7 T1FXQ7 20213605 PTHR19857:SF27 MITOCHONDRIAL DIVISION PROTEIN 1-RELATED ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cell motility#GO:0048870;cell migration#GO:0016477;cell adhesion#GO:0007155;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG165184|UniProtKB=T1EWE4 T1EWE4 20200894 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED INHIBITOR 1, PUTATIVE-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG181518|UniProtKB=T1FH29 T1FH29 20208128 PTHR12317:SF0 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYLTRANSFERASE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;neutral lipid metabolic process#GO:0006638;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;triglyceride biosynthetic process#GO:0019432;glycerolipid metabolic process#GO:0046486 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG160169|UniProtKB=T1EPX0 T1EPX0 20198620 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG163185|UniProtKB=T1ETS0 T1ETS0 20199970 PTHR11960:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;translation factor activity#GO:0180051;RNA binding#GO:0003723;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG156435|UniProtKB=T1ELW6 T1ELW6 20197566 PTHR10137:SF0 V-TYPE PROTON ATPASE SUBUNIT C V-TYPE PROTON ATPASE SUBUNIT C monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;ATPase complex#GO:1904949;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG178481|UniProtKB=T1FD87 T1FD87 20206786 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG140459|UniProtKB=T1EJ09 T1EJ09 20196559 PTHR28670:SF1 UV-STIMULATED SCAFFOLD PROTEIN A UV-STIMULATED SCAFFOLD PROTEIN A binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase core enzyme binding#GO:0043175 cellular response to stress#GO:0033554;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;nucleic acid metabolic process#GO:0090304;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;response to UV#GO:0009411;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;response to stress#GO:0006950;cellular process#GO:0009987;response to radiation#GO:0009314 intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG157040|UniProtKB=T1EM52 T1EM52 20197652 PTHR47981:SF1 RAB FAMILY SMALL MONOMERIC GTPASE GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 phagolysosome assembly#GO:0001845;intracellular transport#GO:0046907;phagocytosis#GO:0006909;transport#GO:0006810;lytic vacuole organization#GO:0080171;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;endosomal transport#GO:0016197;receptor-mediated endocytosis#GO:0006898;vesicle organization#GO:0016050;retrograde transport, endosome to Golgi#GO:0042147;membrane fusion#GO:0061025;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome organization#GO:0007040;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle assembly#GO:0070925;localization#GO:0051179;cellular localization#GO:0051641;vacuole organization#GO:0007033;cellular component organization#GO:0016043;endocytosis#GO:0006897;vesicle fusion#GO:0006906;cytosolic transport#GO:0016482 intracellular organelle#GO:0043229;endosome#GO:0005768;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole#GO:0000323;late endosome#GO:0005770;phagocytic vesicle#GO:0045335;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG189102|UniProtKB=T1FQN4 T1FQN4 20211131 PTHR21074:SF0 IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN IQ MOTIF AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;acrosomal vesicle#GO:0001669;cilium#GO:0005929;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG190881|UniProtKB=T1FSD9 T1FSD9 20211736 PTHR11216:SF181 EH DOMAIN DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular localization#GO:0051641;synaptic vesicle endocytosis#GO:0048488;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;intracellular transport#GO:0046907;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;endosomal transport#GO:0016197;receptor-mediated endocytosis#GO:0006898;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG164197|UniProtKB=T1EV31 T1EV31 20200431 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG82010|UniProtKB=T1G4L9 T1G4L9 20216017 PTHR12622:SF45 DELTEX-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG127118|UniProtKB=T1EHD0 T1EHD0 20195980 PTHR10496:SF0 40S RIBOSOMAL PROTEIN S24 40S RIBOSOMAL PROTEIN S24 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG132379|UniProtKB=T1EHY2 T1EHY2 20196182 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;detection of stimulus#GO:0051606;signal transduction#GO:0007165;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;cellular process#GO:0009987;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to radiation#GO:0071478 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG157883|UniProtKB=T1EMH3 T1EMH3 20197773 PTHR12921:SF0 UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1 UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;macroautophagy#GO:0016236;response to stimulus#GO:0050896;catabolic process#GO:0009056;autophagy#GO:0006914;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;reticulophagy#GO:0061709 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166765|UniProtKB=T1EYH7 T1EYH7 20201627 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG132363|UniProtKB=T1EHY1 T1EHY1 20196181 PTHR24346:SF49 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE NIM1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169378|UniProtKB=T1F1V5 T1F1V5 20202805 PTHR13593:SF113 FAMILY NOT NAMED PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG134296|UniProtKB=T1EI40 T1EI40 20196240 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG143175|UniProtKB=T1EJ92 T1EJ92 20196642 PTHR21032:SF0 G PATCH DOMAIN-CONTAINING PROTEIN 11 G PATCH DOMAIN-CONTAINING PROTEIN 11 RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;biosynthetic process#GO:0009058;RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161325|UniProtKB=T1ERC4 T1ERC4 20199124 PTHR11388:SF157 ORGANIC ANION TRANSPORTER ORGANIC ANION TRANSPORTING POLYPEPTIDE 30B, ISOFORM A secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323 transporter#PC00227 HELRO|EnsemblGenome=HelroG178960|UniProtKB=T1FDZ0 T1FDZ0 20207039 PTHR43731:SF14 RHOMBOID PROTEASE PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 serine protease#PC00203 HELRO|EnsemblGenome=HelroG173047|UniProtKB=T1F6A6 T1F6A6 20204355 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158818|UniProtKB=T1ENA9 T1ENA9 20198059 PTHR32226:SF2 TELO2-INTERACTING PROTEIN 2 TELO2-INTERACTING PROTEIN 2 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG66976|UniProtKB=T1FYU5 T1FYU5 20213993 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG76537|UniProtKB=T1G2L2 T1G2L2 20215310 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regionalization#GO:0003002;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;anterior/posterior pattern specification#GO:0009952;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG161456|UniProtKB=T1ERH5 T1ERH5 20199175 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153371|UniProtKB=T1EL54 T1EL54 20197304 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG73207|UniProtKB=T1G1B7 T1G1B7 20214865 PTHR11945:SF866 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;histone deacetylase binding#GO:0042826;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;Oxidative stress response#P00046>MEF-2#P01128 HELRO|EnsemblGenome=HelroG169120|UniProtKB=T1F1F6 T1F1F6 20202656 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG167026|UniProtKB=T1EYX0 T1EYX0 20201770 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG182970|UniProtKB=T1FJ05 T1FJ05 20208804 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167700|UniProtKB=T1EZP6 T1EZP6 20202046 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629 regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG107672|UniProtKB=T1EEC2 T1EEC2 20194924 PTHR11347:SF198 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE, ISOFORM I phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG97753|UniProtKB=T1G9I8 T1G9I8 20217735 PTHR10603:SF7 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;regulation of cellular process#GO:0050794;RNA transport#GO:0050658;mRNA transport#GO:0051028;modulation of chemical synaptic transmission#GO:0050804;establishment of RNA localization#GO:0051236;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;regulation of RNA stability#GO:0043487;localization#GO:0051179;positive regulation of biosynthetic process#GO:0009891;nucleic acid transport#GO:0050657;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;positive regulation of translation#GO:0045727;regulation of RNA metabolic process#GO:0051252;regulation of translation#GO:0006417;macromolecule localization#GO:0033036;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nitrogen compound transport#GO:0071705;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of synaptic plasticity#GO:0048167;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;transport#GO:0006810;regulation of cell differentiation#GO:0045595;regulation of neuronal synaptic plasticity#GO:0048168;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of nervous system development#GO:0051962;regulation of mRNA stability#GO:0043488;animal gross anatomical part developmental process#GO:0160108;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of trans-synaptic signaling#GO:0099177;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;positive regulation of cell differentiation#GO:0045597;animal organ development#GO:0048513;regulation of mRNA metabolic process#GO:1903311 cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;neuron projection#GO:0043005;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG194841|UniProtKB=T1FWH1 T1FWH1 20213166 PTHR13297:SF5 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG179816|UniProtKB=T1FF66 T1FF66 20207465 PTHR15315:SF112 RING FINGER PROTEIN 41, 151 PDZ DOMAIN CONTAINING RING FINGER 3 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 HELRO|EnsemblGenome=HelroG90066|UniProtKB=T1G7K7 T1G7K7 20217054 PTHR10529:SF344 AP COMPLEX SUBUNIT MU PROTEIN STONED-B protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 biological regulation#GO:0065007;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;regulation of localization#GO:0032879;regulation of transport#GO:0051049;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;Golgi vesicle transport#GO:0048193;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulation of endocytosis#GO:0030100;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;regulation of cellular component organization#GO:0051128;clathrin-dependent endocytosis#GO:0072583;regulation of biological process#GO:0050789;synaptic vesicle endocytosis#GO:0048488;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;synaptic vesicle#GO:0008021;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane coat#GO:0030117;plasma membrane#GO:0005886;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell periphery#GO:0071944;cytosol#GO:0005829;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136;coated vesicle membrane#GO:0030662;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;organelle subcompartment#GO:0031984;endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;vesicle coat#GO:0030120;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;presynapse#GO:0098793;secretory vesicle#GO:0099503;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG193551|UniProtKB=T1FV43 T1FV43 20212689 PTHR10520:SF12 TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleobase metabolic process#GO:0006144;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 De novo purine biosynthesis#P02738>Phosphoribosylamine glycine ligase#P02908 HELRO|EnsemblGenome=HelroG108446|UniProtKB=T1EEI9 T1EEI9 20194991 PTHR13693:SF2 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE PALMITOYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;ceramide biosynthetic process#GO:0046513;ceramide metabolic process#GO:0006672;sphingoid biosynthetic process#GO:0046520 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transaminase#PC00216 HELRO|EnsemblGenome=HelroG141692|UniProtKB=T1EJ40 T1EJ40 20196590 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG157967|UniProtKB=T1EMI2 T1EMI2 20197782 PTHR12144:SF0 NEGATIVE ELONGATION FACTOR D NEGATIVE ELONGATION FACTOR C_D nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG191730|UniProtKB=T1FT86 T1FT86 20212033 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG103786|UniProtKB=T1EDH5 T1EDH5 20194627 PTHR11909:SF428 CASEIN KINASE-RELATED DISCS OVERGROWN PROTEIN KINASE-RELATED catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;positive regulation of Wnt signaling pathway#GO:0030177;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of catabolic process#GO:0009894;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of signal transduction#GO:0009967 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG192795|UniProtKB=T1FUB0 T1FUB0 20212406 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 6 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG77448|UniProtKB=T1G2X9 T1G2X9 20215427 PTHR13094:SF1 NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10 respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG87910|UniProtKB=T1G6W6 T1G6W6 20216813 PTHR23506:SF26 GH10249P MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;monoamine transmembrane transporter activity#GO:0008504;transporter activity#GO:0005215;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG186286|UniProtKB=T1FNX2 T1FNX2 20210519 PTHR23389:SF3 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG163101|UniProtKB=T1ETN3 T1ETN3 20199933 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG185538|UniProtKB=T1FMY1 T1FMY1 20210180 PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE carbon-sulfur lyase activity#GO:0016846;lyase activity#GO:0016829;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;sulfur compound metabolic process#GO:0006790 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 lyase#PC00144;metabolite interconversion enzyme#PC00262 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HELRO|EnsemblGenome=HelroG185946|UniProtKB=T1FNG9 T1FNG9 20210366 PTHR11431:SF75 FERRITIN FERRITIN ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169;ferrous iron binding#GO:0008198;iron ion binding#GO:0005506 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 storage protein#PC00210 HELRO|EnsemblGenome=HelroG91895|UniProtKB=T1G8A3 T1G8A3 20217300 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG165469|UniProtKB=T1EWV0 T1EWV0 20201050 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75829|UniProtKB=T1G2A8 T1G2A8 20215206 PTHR43329:SF141 EPOXIDE HYDROLASE AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED ether hydrolase activity#GO:0016803;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG66923|UniProtKB=T1FYT2 T1FYT2 20213980 PTHR24418:SF474 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;non-membrane spanning protein tyrosine kinase activity#GO:0004715 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG93262|UniProtKB=T1G8U6 T1G8U6 20217493 PTHR11071:SF581 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG167572|UniProtKB=T1EZI1 T1EZI1 20201981 PTHR45617:SF171 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG62778|UniProtKB=T1FX52 T1FX52 20213400 PTHR11042:SF183 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 reproductive process#GO:0022414;meiotic cell cycle#GO:0051321;cell cycle#GO:0007049;sexual reproduction#GO:0019953;cellular process#GO:0009987 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG180974|UniProtKB=T1FGH1 T1FGH1 20207920 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG85027|UniProtKB=T1G5R5 T1G5R5 20216412 PTHR13507:SF0 PRKR-INTERACTING PROTEIN 1 PRKR-INTERACTING PROTEIN 1 enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HELRO|EnsemblGenome=HelroG109107|UniProtKB=T1EEQ4 T1EEQ4 20195056 PTHR46237:SF2 CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER CYTOCHROME B5 REDUCTASE 4 oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular process#GO:0009987;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;superoxide metabolic process#GO:0006801 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 reductase#PC00198 HELRO|EnsemblGenome=HelroG168751|UniProtKB=T1F0X4 T1F0X4 20202474 PTHR10972:SF220 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN steroid binding#GO:0005496;cholesterol binding#GO:0015485;lipid binding#GO:0008289;alcohol binding#GO:0043178;sterol binding#GO:0032934;small molecule binding#GO:0036094;binding#GO:0005488 cytosol#GO:0005829;membrane#GO:0016020;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG172395|UniProtKB=T1F593 T1F593 20203992 PTHR44733:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 22 DNAJ HOMOLOG SUBFAMILY C MEMBER 22 cellular anatomical structure#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HELRO|EnsemblGenome=HelroG190925|UniProtKB=T1FSF3 T1FSF3 20211750 PTHR22883:SF475 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC23 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity, acting on a protein#GO:0140096 protein localization to membrane#GO:0072657;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein targeting#GO:0006605;protein localization to cell periphery#GO:1990778;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164379|UniProtKB=T1EVC7 T1EVC7 20200527 PTHR23108:SF0 METHYLTRANSFERASE-RELATED METHYLTRANSFERASE-LIKE PROTEIN 22 methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG179209|UniProtKB=T1FED0 T1FED0 20207179 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;localization#GO:0051179;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG63913|UniProtKB=T1FXM4 T1FXM4 20213572 PTHR12027:SF91 WNT RELATED PROTO-ONCOGENE WNT-1 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell fate commitment#GO:0045165;system development#GO:0048731 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HELRO|EnsemblGenome=HelroG188733|UniProtKB=T1FQB2 T1FQB2 20211009 PTHR14084:SF0 KYNURENINASE KYNURENINASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787 small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;indole-containing compound metabolic process#GO:0042430;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG189038|UniProtKB=T1FQK9 T1FQK9 20211106 PTHR22652:SF0 NUCLEOPORIN NUP43 NUCLEOPORIN NUP43 nuclear pore outer ring#GO:0031080;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HELRO|EnsemblGenome=HelroG167043|UniProtKB=T1EYX9 T1EYX9 20201779 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183585|UniProtKB=T1FJV8 T1FJV8 20209107 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154266|UniProtKB=T1ELE3 T1ELE3 20197393 PTHR10494:SF6 BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN NOGGIN negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of BMP signaling pathway#GO:0030514;regulation of BMP signaling pathway#GO:0030510;negative regulation of response to stimulus#GO:0048585;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG117113|UniProtKB=T1EGK2 T1EGK2 20195703 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG75296|UniProtKB=T1G234 T1G234 20215132 PTHR13544:SF0 SELENOPROTEIN T THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 cell redox homeostasis#GO:0045454;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG150185|UniProtKB=T1EKE6 T1EKE6 20197046 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to chemical#GO:0042221;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202;response to xenobiotic stimulus#GO:0009410;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;lipid metabolic process#GO:0006629 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG107800|UniProtKB=T1EEC7 T1EEC7 20194929 PTHR13759:SF10 TWINFILIN TWINFILIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin monomer binding#GO:0003785 regulation of anatomical structure size#GO:0090066;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;actin filament depolymerization#GO:0030042;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;cellular component disassembly#GO:0022411;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of protein depolymerization#GO:1901879;actin filament organization#GO:0007015;regulation of plasma membrane bounded cell projection organization#GO:0120035;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;protein depolymerization#GO:0051261;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;regulation of cell projection assembly#GO:0060491;supramolecular fiber organization#GO:0097435;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of actin filament depolymerization#GO:0030834;protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG97044|UniProtKB=T1G9F0 T1G9F0 20217697 PTHR47385:SF14 CALPONIN TRANSGELIN binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG195023|UniProtKB=T1FWN6 T1FWN6 20213231 PTHR21567:SF90 CLASP TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 1 ISOFORM X1 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;cilium#GO:0005929;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG178927|UniProtKB=T1FDW8 T1FDW8 20207017 PTHR24260:SF149 AT07769P-RELATED AT07769P-RELATED HELRO|EnsemblGenome=HelroG78053|UniProtKB=T1G372 T1G372 20215520 PTHR12936:SF0 ANAPHASE-PROMOTING COMPLEX 10 ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;cell cycle#GO:0007049;primary metabolic process#GO:0044238;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538 organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 Cell cycle#P00013>APC#P00481 HELRO|EnsemblGenome=HelroG185160|UniProtKB=T1FMG5 T1FMG5 20210014 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG194396|UniProtKB=T1FW05 T1FW05 20213001 PTHR13083:SF3 WD REPEAT-CONTAINING PROTEIN 91 WD REPEAT-CONTAINING PROTEIN 91 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;early endosome to late endosome transport#GO:0045022;cellular process#GO:0009987 late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;late endosome membrane#GO:0031902;early endosome membrane#GO:0031901;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG191220|UniProtKB=T1FSR3 T1FSR3 20211860 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG183224|UniProtKB=T1FJC2 T1FJC2 20208921 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114139|UniProtKB=T1EFZ6 T1EFZ6 20195498 PTHR10202:SF27 PRESENILIN PRESENILIN HOMOLOG catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cell communication#GO:0007154;protein metabolic process#GO:0019538;proteolysis#GO:0006508;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;cell surface receptor signaling pathway#GO:0007166;membrane protein ectodomain proteolysis#GO:0006509;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;signal transduction#GO:0007165;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485 membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;catalytic complex#GO:1902494 protease#PC00190;aspartic protease#PC00053 Alzheimer disease-amyloid secretase pathway#P00003>Presenilin N-terminal fragment#P00088;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin C-terminal fragment#P00102;Alzheimer disease-presenilin pathway#P00004>Presenilin N-terminal fragment#P00140;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin#P00098;Alzheimer disease-presenilin pathway#P00004>Presenilin#P00129;Alzheimer disease-presenilin pathway#P00004>Presenilin C-terminal fragment#P00155;Notch signaling pathway#P00045>Presenilin#P01110 HELRO|EnsemblGenome=HelroG71395|UniProtKB=T1G0K7 T1G0K7 20214605 PTHR10264:SF127 BAND 7 PROTEIN-RELATED BAND 7 PROTEIN CG42540 ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG131046|UniProtKB=T1EHV1 T1EHV1 20196151 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG68923|UniProtKB=T1FZL7 T1FZL7 20214265 PTHR13622:SF14 THIAMIN PYROPHOSPHOKINASE THIAMINE PYROPHOSPHOKINASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;alcohol biosynthetic process#GO:0046165;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 kinase#PC00137;transferase#PC00220 Thiamin metabolism#P02780>Thiamine kinase#P03176 HELRO|EnsemblGenome=HelroG193914|UniProtKB=T1FVH0 T1FVH0 20212816 PTHR16777:SF2 PROTEIN ECT2 PROTEIN ECT2 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 mitotic cell cycle process#GO:1903047;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell division#GO:0051301;cell cycle process#GO:0022402;cell cycle#GO:0007049 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cell periphery#GO:0071944;cell cortex#GO:0005938 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG183800|UniProtKB=T1FK77 T1FK77 20209226 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158385|UniProtKB=T1EMQ9 T1EMQ9 20197859 PTHR12231:SF279 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN ROUNDABOUT 1, ISOFORM A-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 animal gross anatomical part developmental process#GO:0160108;cell recognition#GO:0008037;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;axon development#GO:0061564;axon guidance#GO:0007411;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399 cell projection membrane#GO:0031253;neuron projection membrane#GO:0032589;leading edge membrane#GO:0031256;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;main axon#GO:0044304;neuron projection#GO:0043005;membrane#GO:0016020;cell leading edge#GO:0031252 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG104619|UniProtKB=T1EDM6 T1EDM6 20194678 PTHR22840:SF12 WD REPEAT-CONTAINING PROTEIN 36 WD REPEAT-CONTAINING PROTEIN 36 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;90S preribosome#GO:0030686;small-subunit processome#GO:0032040;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG117195|UniProtKB=T1EGK9 T1EGK9 20195709 PTHR12786:SF1 SPLICING FACTOR SF3A-RELATED SPLICING REGULATOR SDE2 RNA binding#GO:0003723;snoRNA binding#GO:0030515;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG110971|UniProtKB=T1EF67 T1EF67 20195219 PTHR11785:SF528 AMINO ACID TRANSPORTER LD25378P carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG181759|UniProtKB=T1FHA6 T1FHA6 20208205 PTHR13060:SF0 SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2 PROTEIN ECDYSONELESS HOMOLOG transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG175342|UniProtKB=T1F963 T1F963 20205362 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG182457|UniProtKB=T1FI82 T1FI82 20208531 PTHR17602:SF4 RIBOSOME BIOGENESIS REGULATORY PROTEIN RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG159553|UniProtKB=T1EP56 T1EP56 20198356 PTHR22655:SF2 ATP-DEPENDENT RNA HELICASE TDRD12-RELATED ATP-DEPENDENT RNA HELICASE TDRD12-RELATED RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;piRNA processing#GO:0034587;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG148261|UniProtKB=T1EK63 T1EK63 20196963 PTHR12547:SF174 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36L2 protein-RNA adaptor activity#GO:0140517;molecular adaptor activity#GO:0060090;translation regulator activity#GO:0045182;mRNA 3'-UTR binding#GO:0003730;binding#GO:0005488;nucleic acid binding#GO:0003676;protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;RNA binding#GO:0003723 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159028|UniProtKB=T1ENI0 T1ENI0 20198130 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED binding#GO:0005488;poly(A) binding#GO:0008143;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG153518|UniProtKB=T1EL85 T1EL85 20197335 PTHR23349:SF63 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FER3-LIKE PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG184319|UniProtKB=T1FKZ5 T1FKZ5 20209494 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG182172|UniProtKB=T1FHV2 T1FHV2 20208401 PTHR24041:SF34 MUCIN EGF-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG156472|UniProtKB=T1ELX3 T1ELX3 20197573 PTHR10539:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular protein-containing complex#GO:0140535;endopeptidase complex#GO:1905369;proteasome regulatory particle, lid subcomplex#GO:0008541;cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome complex#GO:0000502;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Parkinson disease#P00049>19S proteasome#P01209 HELRO|EnsemblGenome=HelroG184236|UniProtKB=T1FKT7 T1FKT7 20209436 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166349|UniProtKB=T1EY17 T1EY17 20201467 PTHR10693:SF88 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN AT27578P nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607 cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160837|UniProtKB=T1EQT0 T1EQT0 20198930 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;system process#GO:0003008;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;muscle contraction#GO:0006936;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;muscle system process#GO:0003012 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG81778|UniProtKB=T1G4I6 T1G4I6 20215984 PTHR23314:SF0 SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING SPERM-ASSOCIATED ANTIGEN 6 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cilium movement#GO:0003341;cellular process#GO:0009987 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG170651|UniProtKB=T1F3A4 T1F3A4 20203303 PTHR16172:SF2 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE JET FUEL, ISOFORM A cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG193538|UniProtKB=T1FV37 T1FV37 20212683 PTHR23512:SF5 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 LYSOSOMAL DIPEPTIDE TRANSPORTER MFSD1 ISOFORM X1 HELRO|EnsemblGenome=HelroG153266|UniProtKB=T1EL22 T1EL22 20197272 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64016|UniProtKB=T1FXN4 T1FXN4 20213582 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS HOMEOTIC PROTEIN FEMALE STERILE-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164476|UniProtKB=T1EVH1 T1EVH1 20200571 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN EXPRESSED PROTEIN transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG73641|UniProtKB=T1G1G7 T1G1G7 20214915 PTHR45817:SF4 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE-LIKE-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 HELRO|EnsemblGenome=HelroG174243|UniProtKB=T1F7V4 T1F7V4 20204903 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178814|UniProtKB=T1FDS2 T1FDS2 20206971 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG111085|UniProtKB=T1EF79 T1EF79 20195231 PTHR11584:SF395 SERINE/THREONINE PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;p38MAPK cascade#GO:0038066;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG64185|UniProtKB=T1FXR0 T1FXR0 20213608 PTHR10794:SF45 ABHYDROLASE DOMAIN-CONTAINING PROTEIN MONOACYLGLYCEROL LIPASE ABHD2 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 gamete generation#GO:0007276;glycerolipid metabolic process#GO:0046486;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;cell differentiation#GO:0030154;signaling#GO:0023052;carboxylic acid metabolic process#GO:0019752;response to endogenous stimulus#GO:0009719;hormone-mediated signaling pathway#GO:0009755;spermatid differentiation#GO:0048515;glycerolipid catabolic process#GO:0046503;oxoacid metabolic process#GO:0043436;response to lipid#GO:0033993;response to chemical#GO:0042221;sperm capacitation#GO:0048240;response to hormone#GO:0009725;acylglycerol catabolic process#GO:0046464;metabolic process#GO:0008152;catabolic process#GO:0009056;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;carboxylic acid biosynthetic process#GO:0046394;cell communication#GO:0007154;male gamete generation#GO:0048232;fatty acid biosynthetic process#GO:0006633;carboxylic acid catabolic process#GO:0046395;cellular developmental process#GO:0048869;neutral lipid metabolic process#GO:0006638;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;small molecule catabolic process#GO:0044282;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;monocarboxylic acid metabolic process#GO:0032787;regulation of biological process#GO:0050789;fatty acid catabolic process#GO:0009062;cellular response to chemical stimulus#GO:0070887;cellular response to lipid#GO:0071396;cellular process#GO:0009987;lipid catabolic process#GO:0016042;signal transduction#GO:0007165;cellular response to steroid hormone stimulus#GO:0071383;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;germ cell development#GO:0007281;steroid hormone receptor signaling pathway#GO:0043401;anatomical structure maturation#GO:0071695;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;response to steroid hormone#GO:0048545;spermatid development#GO:0007286;sexual reproduction#GO:0019953;monocarboxylic acid catabolic process#GO:0072329;lipid biosynthetic process#GO:0008610;developmental maturation#GO:0021700;biosynthetic process#GO:0009058;biological regulation#GO:0065007;monocarboxylic acid biosynthetic process#GO:0072330;cell maturation#GO:0048469;acylglycerol metabolic process#GO:0006639;fatty acid metabolic process#GO:0006631;neutral lipid catabolic process#GO:0046461 plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG192808|UniProtKB=T1FUB6 T1FUB6 20212412 PTHR14222:SF2 CONDENSIN CONDENSIN COMPLEX SUBUNIT 1 histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;organelle fission#GO:0048285;sexual reproduction#GO:0019953;nuclear division#GO:0000280;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;sister chromatid segregation#GO:0000819;cell cycle#GO:0007049 chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;condensin complex#GO:0000796;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG79940|UniProtKB=T1G3V4 T1G3V4 20215752 PTHR11256:SF41 BCL-2 RELATED BCL-2 HOMOLOGOUS ANTAGONIST_KILLER channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;response to stress#GO:0006950;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Apoptosis signaling pathway#P00006>Bak#P00275 HELRO|EnsemblGenome=HelroG161517|UniProtKB=T1ERL0 T1ERL0 20199210 PTHR20963:SF56 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG164040|UniProtKB=T1EUT3 T1EUT3 20200333 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG191219|UniProtKB=T1FSR2 T1FSR2 20211859 PTHR13140:SF880 MYOSIN DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;microfilament motor activity#GO:0000146 actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG179298|UniProtKB=T1FEI1 T1FEI1 20207230 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181450|UniProtKB=T1FH08 T1FH08 20208107 PTHR47246:SF1 MUCIN-19 MUCIN-19 HELRO|EnsemblGenome=HelroG167079|UniProtKB=T1EYZ8 T1EYZ8 20201798 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG159054|UniProtKB=T1ENJ4 T1ENJ4 20198144 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG168746|UniProtKB=T1F0X0 T1F0X0 20202470 PTHR15641:SF1 ELONGATOR COMPLEX PROTEIN 5 ELONGATOR COMPLEX PROTEIN 5 nucleic acid binding#GO:0003676;binding#GO:0005488;tRNA binding#GO:0000049;RNA binding#GO:0003723 tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;elongator holoenzyme complex#GO:0033588;cytosol#GO:0005829;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG179365|UniProtKB=T1FEL9 T1FEL9 20207268 PTHR15921:SF3 PRE-MRNA CLEAVAGE COMPLEX II PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11 RNA polymerase binding#GO:0070063;RNA polymerase core enzyme binding#GO:0043175;enzyme binding#GO:0019899;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;termination of RNA polymerase II transcription#GO:0006369;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG157317|UniProtKB=T1EM95 T1EM95 20197695 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG62917|UniProtKB=T1FX75 T1FX75 20213423 PTHR46161:SF1 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE 5 transferase#PC00220;kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HELRO|EnsemblGenome=HelroG179614|UniProtKB=T1FEX9 T1FEX9 20207378 PTHR21533:SF19 LEUCINE-RICH PROTEIN LEUCINE-RICH PROTEIN HELRO|EnsemblGenome=HelroG82781|UniProtKB=T1G4W5 T1G4W5 20216113 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267 transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HELRO|EnsemblGenome=HelroG171558|UniProtKB=T1F4E7 T1F4E7 20203696 PTHR47977:SF126 RAS-RELATED PROTEIN RAB EF-HAND DOMAIN-CONTAINING PROTEIN purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG167563|UniProtKB=T1EZH8 T1EZH8 20201978 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG180933|UniProtKB=T1FGG0 T1FGG0 20207909 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185747|UniProtKB=T1FN85 T1FN85 20210283 PTHR47979:SF150 DRAB11-RELATED RAB2A, MEMBER RAS ONCOGENE FAMILY catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 PDGF signaling pathway#P00047>Ras#P01154 HELRO|EnsemblGenome=HelroG180473|UniProtKB=T1FFZ1 T1FFZ1 20207740 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG84811|UniProtKB=T1G5N9 T1G5N9 20216386 PTHR46197:SF3 PROTEIN ABHD14B-LIKE AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG140768|UniProtKB=T1EJ18 T1EJ18 20196568 PTHR24256:SF579 TRYPTASE-RELATED WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 1 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG90503|UniProtKB=T1G7S4 T1G7S4 20217121 PTHR43520:SF35 ATP7, ISOFORM B P-TYPE CU(+) TRANSPORTER active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;cation binding#GO:0043169;transition metal ion binding#GO:0046914;ion binding#GO:0043167;small molecule binding#GO:0036094;metal ion transmembrane transporter activity#GO:0046873;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;copper ion binding#GO:0005507;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion binding#GO:0046872;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transition metal ion transmembrane transporter activity#GO:0046915;binding#GO:0005488 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;copper ion transmembrane transport#GO:0035434;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801 cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG176569|UniProtKB=T1FAN8 T1FAN8 20205887 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG158765|UniProtKB=T1EN84 T1EN84 20198034 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG190692|UniProtKB=T1FS75 T1FS75 20211672 PTHR16055:SF2 INTEGRATOR COMPLEX SUBUNIT 10 INTEGRATOR COMPLEX SUBUNIT 10 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;integrator complex#GO:0032039;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG77586|UniProtKB=T1G302 T1G302 20215450 PTHR11265:SF0 S-ADENOSYL-METHYLTRANSFERASE MRAW 12S RRNA N(4)-CYTIDINE METHYLTRANSFERASE METTL15 N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a rRNA#GO:0140102;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098 macromolecule biosynthetic process#GO:0009059;rRNA base methylation#GO:0070475;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;methylation#GO:0032259 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG67025|UniProtKB=T1FYV3 T1FYV3 20214001 PTHR43557:SF4 APOPTOSIS-INDUCING FACTOR 1 APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL oxidoreductase activity, acting on NAD(P)H#GO:0016651;anion binding#GO:0043168;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;binding#GO:0005488;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824 programmed cell death#GO:0012501;establishment of localization in cell#GO:0051649;apoptotic process#GO:0006915;cellular process#GO:0009987;cell death#GO:0008219;mitochondrial transport#GO:0006839;mitochondrial protein import pathway#GO:7770058;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 Apoptosis signaling pathway#P00006>AIF#P00286 HELRO|EnsemblGenome=HelroG178484|UniProtKB=T1FD89 T1FD89 20206788 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG185213|UniProtKB=T1FMI6 T1FMI6 20210035 PTHR23091:SF4 N-TERMINAL ACETYLTRANSFERASE N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein acetyltransferase complex#GO:0031248;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG75552|UniProtKB=T1G263 T1G263 20215161 PTHR43655:SF8 ATP-DEPENDENT PROTEASE MITOCHONDRIAL INNER MEMBRANE M-AAA PROTEASE COMPONENT PARAPLEGIN catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;peptidase complex#GO:1905368;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG189456|UniProtKB=T1FR28 T1FR28 20211275 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG123385|UniProtKB=T1EGX7 T1EGX7 20195827 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG181690|UniProtKB=T1FH86 T1FH86 20208185 PTHR31654:SF0 SECRETED BETA-GLUCOSIDASE ADG3-RELATED SECRETED BETA-GLUCOSIDASE ADG3-RELATED glucosidase#PC00108;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185950|UniProtKB=T1FNH2 T1FNH2 20210369 PTHR10476:SF17 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1A establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;macromolecule localization#GO:0033036;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;late endosome to vacuole transport#GO:0045324;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178337|UniProtKB=T1FD32 T1FD32 20206731 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167614|UniProtKB=T1EZK3 T1EZK3 20202003 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG194573|UniProtKB=T1FW75 T1FW75 20213071 PTHR11679:SF71 VESICLE PROTEIN SORTING-ASSOCIATED SEC1 FAMILY DOMAIN-CONTAINING PROTEIN 2 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG190261|UniProtKB=T1FRU0 T1FRU0 20211537 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165734|UniProtKB=T1EX82 T1EX82 20201182 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG124648|UniProtKB=T1EH22 T1EH22 20195872 PTHR24070:SF290 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE, FAMILY 10, MEMBER A hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG188504|UniProtKB=T1FQ23 T1FQ23 20210920 PTHR12419:SF10 OTU DOMAIN CONTAINING PROTEIN UBIQUITINYL HYDROLASE 1 catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG165645|UniProtKB=T1EX43 T1EX43 20201143 PTHR12850:SF5 40S RIBOSOMAL PROTEIN S25 SMALL RIBOSOMAL SUBUNIT PROTEIN ES25 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG88134|UniProtKB=T1G6Y8 T1G6Y8 20216835 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN 7, ISOFORM A phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515;molecular sensor activity#GO:0140299;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772 localization#GO:0051179;regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of cellular process#GO:0050794;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;vesicle organization#GO:0016050;transport#GO:0006810;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;biological regulation#GO:0065007;organelle membrane fusion#GO:0090174;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG81424|UniProtKB=T1G4E2 T1G4E2 20215940 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177629|UniProtKB=T1FBY7 T1FBY7 20206336 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194594|UniProtKB=T1FW85 T1FW85 20213081 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG62259|UniProtKB=T1FWX9 T1FWX9 20213327 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG169422|UniProtKB=T1F1X0 T1F1X0 20202820 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN binding#GO:0005488;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;syntaxin binding#GO:0019905;SNARE binding#GO:0000149;enzyme activator activity#GO:0008047;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772 Golgi vesicle transport#GO:0048193;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;exocytosis#GO:0006887;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;regulation of establishment or maintenance of cell polarity#GO:0032878;cytoskeleton organization#GO:0007010;establishment or maintenance of cell polarity#GO:0007163;regulation of signaling#GO:0023051;spindle localization#GO:0051653;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;secretion by cell#GO:0032940;cellular component organization#GO:0016043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;transport#GO:0006810;regulation of response to stimulus#GO:0048583;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of spindle localization#GO:0051293;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;organelle localization#GO:0051640;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;regulation of Notch signaling pathway#GO:0008593;localization within membrane#GO:0051668;secretion#GO:0046903;microtubule cytoskeleton organization#GO:0000226;cortical actin cytoskeleton organization#GO:0030866;localization#GO:0051179;cell cycle#GO:0007049;establishment of cell polarity#GO:0030010;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;Golgi to plasma membrane transport#GO:0006893;regulation of cell communication#GO:0010646 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG80378|UniProtKB=T1G401 T1G401 20215799 PTHR23113:SF374 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-GEF DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of signaling#GO:0023051;Ras protein signal transduction#GO:0007265;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG189931|UniProtKB=T1FRH9 T1FRH9 20211426 PTHR13437:SF2 NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1 NUCLEOPORIN P58_P45 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;transport#GO:0006810;nucleocytoplasmic transport#GO:0006913;intracellular transport#GO:0046907;nuclear transport#GO:0051169;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 transporter#PC00227 HELRO|EnsemblGenome=HelroG88699|UniProtKB=T1G755 T1G755 20216902 PTHR12924:SF0 TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191050|UniProtKB=T1FSJ5 T1FSJ5 20211792 PTHR18911:SF5 CTCL TUMOR ANTIGEN HD-CL-01 COILED-COIL DOMAIN-CONTAINING PROTEIN 186 HELRO|EnsemblGenome=HelroG161763|UniProtKB=T1ERV6 T1ERV6 20199306 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG69195|UniProtKB=T1FZQ8 T1FZQ8 20214306 PTHR15454:SF73 NISCHARIN RELATED DYNEIN AXONEMAL LIGHT CHAIN 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG90476|UniProtKB=T1G7R9 T1G7R9 20217116 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG67929|UniProtKB=T1FZ79 T1FZ79 20214127 PTHR45788:SF4 SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;citrate transmembrane transporter activity#GO:0015137;active transmembrane transporter activity#GO:0022804 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;tricarboxylic acid transport#GO:0006842;citrate transport#GO:0015746;carboxylic acid transmembrane transport#GO:1905039;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HELRO|EnsemblGenome=HelroG124128|UniProtKB=T1EH02 T1EH02 20195852 PTHR12159:SF9 G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA N-glycosylase activity#GO:0019104;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity, acting on DNA#GO:0140097 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG188886|UniProtKB=T1FQF7 T1FQF7 20211054 PTHR16206:SF4 DEP DOMAIN-CONTAINING PROTEIN LET-99 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105121|UniProtKB=T1EDR0 T1EDR0 20194712 PTHR24292:SF105 CYTOCHROME P450 CYTOCHROME P450 6A16, ISOFORM B-RELATED oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164079|UniProtKB=T1EUW1 T1EUW1 20200361 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG101539|UniProtKB=T1ED53 T1ED53 20194505 PTHR24215:SF37 RHO-GTPASE-ACTIVATING PROTEIN LRG1 CYSTEINE-RICH PROTEIN 1 actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG182707|UniProtKB=T1FIM2 T1FIM2 20208671 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110990|UniProtKB=T1EF69 T1EF69 20195221 PTHR10218:SF360 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG signaling receptor binding#GO:0005102;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;protein binding#GO:0005515;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;G protein-coupled receptor binding#GO:0001664;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154 brush border#GO:0005903;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;brush border membrane#GO:0031526;protein-containing complex#GO:0032991;apical part of cell#GO:0045177;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;apical plasma membrane#GO:0016324;cytoplasmic side of plasma membrane#GO:0009898;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;cell projection membrane#GO:0031253;side of membrane#GO:0098552 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG108942|UniProtKB=T1EEP1 T1EEP1 20195043 PTHR45700:SF2 UBIQUITIN-PROTEIN LIGASE E3C UBIQUITIN-PROTEIN LIGASE E3C transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG71547|UniProtKB=T1G0N1 T1G0N1 20214629 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG169012|UniProtKB=T1F193 T1F193 20202593 PTHR11465:SF9 CATALASE CATALASE oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;tetrapyrrole binding#GO:0046906;binding#GO:0005488;oxidoreductase activity#GO:0016491;heme binding#GO:0020037;catalytic activity#GO:0003824;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209 response to stimulus#GO:0050896;catabolic process#GO:0009056;response to chemical#GO:0042221;hydrogen peroxide metabolic process#GO:0042743;response to stress#GO:0006950;cellular process#GO:0009987;response to oxidative stress#GO:0006979;response to reactive oxygen species#GO:0000302;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to oxygen-containing compound#GO:1901700 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisome#GO:0005777;mitochondrion#GO:0005739;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 peroxidase#PC00180 HELRO|EnsemblGenome=HelroG160138|UniProtKB=T1EPV2 T1EPV2 20198602 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165900|UniProtKB=T1EXF2 T1EXF2 20201252 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178000|UniProtKB=T1FCL1 T1FCL1 20206560 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG185136|UniProtKB=T1FMF9 T1FMF9 20210008 PTHR10722:SF0 60S RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN EL19 RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG113404|UniProtKB=T1EFS3 T1EFS3 20195425 PTHR44489:SF11 FAMILY NOT NAMED WD REPEAT DOMAIN 86 HELRO|EnsemblGenome=HelroG73885|UniProtKB=T1G1K1 T1G1K1 20214949 PTHR44019:SF24 WD REPEAT-CONTAINING PROTEIN 55 POC1 CENTRIOLAR PROTEIN HOMOLOG cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG181969|UniProtKB=T1FHJ5 T1FHJ5 20208294 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG187989|UniProtKB=T1FPI9 T1FPI9 20210736 PTHR22960:SF0 MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1 phosphorus-oxygen lyase activity#GO:0016849;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;lyase activity#GO:0016829 cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG185694|UniProtKB=T1FN57 T1FN57 20210255 PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical structure#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG80455|UniProtKB=T1G410 T1G410 20215808 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG183983|UniProtKB=T1FKE1 T1FKE1 20209290 PTHR45817:SF4 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE-LIKE-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG98557|UniProtKB=T1G9N6 T1G9N6 20217782 PTHR42980:SF1 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494;oxidoreductase complex#GO:1990204 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG84162|UniProtKB=T1G5F7 T1G5F7 20216304 PTHR13344:SF0 NADH-UBIQUINONE OXIDOREDUCTASE NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185462|UniProtKB=T1FMU7 T1FMU7 20210146 PTHR11743:SF70 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL GH26960P-RELATED voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308 intracellular transport#GO:0046907;transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;transmembrane transport#GO:0055085;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mitochondrial transport#GO:0006839 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG177634|UniProtKB=T1FBZ2 T1FBZ2 20206341 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194703|UniProtKB=T1FWC1 T1FWC1 20213117 PTHR11304:SF29 EPHRIN EPHRIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG166715|UniProtKB=T1EYF1 T1EYF1 20201601 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG163446|UniProtKB=T1EU22 T1EU22 20200072 PTHR21694:SF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 HELRO|EnsemblGenome=HelroG174382|UniProtKB=T1F823 T1F823 20204972 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175213|UniProtKB=T1F908 T1F908 20205307 PTHR31198:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 84 CENTROSOMAL AT-AC SPLICING FACTOR HELRO|EnsemblGenome=HelroG167040|UniProtKB=T1EYX8 T1EYX8 20201778 PTHR39940:SF1 PROTHORACICOTROPIC HORMONE, ISOFORM F PROTEIN TRUNK-LIKE molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG168133|UniProtKB=T1F074 T1F074 20202224 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG166800|UniProtKB=T1EYJ5 T1EYJ5 20201645 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81089|UniProtKB=T1G489 T1G489 20215887 PTHR12050:SF0 LEPTIN RECEPTOR-RELATED RH04491P intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169025|UniProtKB=T1F199 T1F199 20202599 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA transcription#GO:0009301;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG66523|UniProtKB=T1FYM3 T1FYM3 20213921 PTHR24031:SF761 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX49-RELATED nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG193603|UniProtKB=T1FV61 T1FV61 20212707 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG179833|UniProtKB=T1FF71 T1FF71 20207470 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190723|UniProtKB=T1FS86 T1FS86 20211683 PTHR43326:SF8 METHIONYL-TRNA SYNTHETASE METHIONINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG194993|UniProtKB=T1FWM7 T1FWM7 20213222 PTHR10048:SF118 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 phosphatidylinositol phosphate biosynthetic process#GO:0046854;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;cell motility#GO:0048870;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;intracellular signaling cassette#GO:0141124;glycerophospholipid metabolic process#GO:0006650;cell migration#GO:0016477;lipid biosynthetic process#GO:0008610 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 kinase#PC00137 Axon guidance mediated by netrin#P00009>PI3K#P00363;Integrin signalling pathway#P00034>PI3K#P00936;p53 pathway feedback loops 2#P04398>PI3K#P04661;PDGF signaling pathway#P00047>PI3K#P01168;Apoptosis signaling pathway#P00006>PI3K#P00310;Ras Pathway#P04393>PI3K#P04567;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Hypoxia response via HIF activation#P00030>PI3K#P00823;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;PI3 kinase pathway#P00048>P110ACT#P01177;VEGF signaling pathway#P00056>PI3K#P01413;PI3 kinase pathway#P00048>p110#P01192;FGF signaling pathway#P00021>PI3K#P00640;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;EGF receptor signaling pathway#P00018>PI3K#P00557;Angiogenesis#P00005>PI3K#P00236 HELRO|EnsemblGenome=HelroG93529|UniProtKB=T1G8W3 T1G8W3 20217510 PTHR10841:SF17 SYNAPSIN SYNAPSIN cytoskeletal adaptor activity#GO:0008093;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;presynapse#GO:0098793;vesicle membrane#GO:0012506;membrane#GO:0016020;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synapsin#P05775 HELRO|EnsemblGenome=HelroG101462|UniProtKB=T1ED48 T1ED48 20194500 PTHR13036:SF0 BETA1,4 MANNOSYLTRANSFERASE CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG81133|UniProtKB=T1G4A0 T1G4A0 20215898 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG158131|UniProtKB=T1EMJ7 T1EMJ7 20197797 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM K-RELATED nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG168079|UniProtKB=T1F052 T1F052 20202202 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG87612|UniProtKB=T1G6T0 T1G6T0 20216777 PTHR11548:SF2 THYMIDYLATE SYNTHASE 1 THYMIDYLATE SYNTHASE transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;catalytic activity#GO:0003824 nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleoside monophosphate biosynthetic process#GO:0009124;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637 mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155;transferase#PC00220 Formyltetrahydrofolate biosynthesis#P02743>Thymidylate synthase#P02954;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>Thymidylate synthase#P02913;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948;Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957 HELRO|EnsemblGenome=HelroG98504|UniProtKB=T1G9N3 T1G9N3 20217779 PTHR45024:SF2 DEHYDROGENASES, SHORT CHAIN SCP2 DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;lyase activity#GO:0016829;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;lipid modification#GO:0030258;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG174345|UniProtKB=T1F811 T1F811 20204960 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89290|UniProtKB=T1G7B5 T1G7B5 20216962 PTHR45951:SF3 PROTEIN DISPATCHED-RELATED PROTEIN DISPATCHED cell communication#GO:0007154;smoothened signaling pathway#GO:0007224;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG159142|UniProtKB=T1ENN4 T1ENN4 20198184 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG157129|UniProtKB=T1EM68 T1EM68 20197668 PTHR23339:SF98 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PRL-1 PHOSPHATASE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG75893|UniProtKB=T1G2C2 T1G2C2 20215220 PTHR11537:SF259 VOLTAGE-GATED POTASSIUM CHANNEL KCNQ POTASSIUM CHANNEL, ISOFORM F voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG67713|UniProtKB=T1FZ44 T1FZ44 20214092 PTHR10681:SF163 THIOREDOXIN PEROXIDASE PEROXIREDOXIN 2-RELATED catalytic activity#GO:0003824;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;response to oxidative stress#GO:0006979;cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;response to stress#GO:0006950;cellular process#GO:0009987;catabolic process#GO:0009056;response to stimulus#GO:0050896;hydrogen peroxide metabolic process#GO:0042743;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG109569|UniProtKB=T1EEV0 T1EEV0 20195102 PTHR24031:SF2 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX55 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG187766|UniProtKB=T1FPD0 T1FPD0 20210677 PTHR12081:SF7 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR EFL-3 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG103347|UniProtKB=T1EDF6 T1EDF6 20194608 PTHR30389:SF0 FUMARATE HYDRATASE-RELATED FUMARATE HYDRATASE CLASS I, AEROBIC hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 lyase#PC00144;hydratase#PC00120 HELRO|EnsemblGenome=HelroG184326|UniProtKB=T1FL02 T1FL02 20209501 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG82370|UniProtKB=T1G4R4 T1G4R4 20216062 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;purine-containing compound metabolic process#GO:0072521;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;purine-containing compound biosynthetic process#GO:0072522;purine nucleoside metabolic process#GO:0042278;nucleoside catabolic process#GO:0009164;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;adenosine metabolic process#GO:0046085;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;purine nucleobase metabolic process#GO:0006144;small molecule biosynthetic process#GO:0044283;carbohydrate derivative biosynthetic process#GO:1901137;purine-containing compound catabolic process#GO:0072523;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside catabolic process#GO:0006152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cytosol#GO:0005829 deaminase#PC00088 HELRO|EnsemblGenome=HelroG185244|UniProtKB=T1FMJ8 T1FMJ8 20210047 PTHR11712:SF362 POLYKETIDE SYNTHASE-RELATED 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 monocarboxylic acid biosynthetic process#GO:0072330;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394 HELRO|EnsemblGenome=HelroG107485|UniProtKB=T1EEA8 T1EEA8 20194910 PTHR43806:SF14 PEPTIDASE S8 TRIPEPTIDYL-PEPTIDASE 2 hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 serine protease#PC00203 HELRO|EnsemblGenome=HelroG115102|UniProtKB=T1EG64 T1EG64 20195566 PTHR23142:SF2 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38B macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG79937|UniProtKB=T1G3V3 T1G3V3 20215751 PTHR23092:SF15 POLY(A) RNA POLYMERASE INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566 modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG191596|UniProtKB=T1FT41 T1FT41 20211988 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME-RELATED cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194208|UniProtKB=T1FVT2 T1FVT2 20212928 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG113318|UniProtKB=T1EFR6 T1EFR6 20195418 PTHR11434:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191131|UniProtKB=T1FSM6 T1FSM6 20211823 PTHR19855:SF12 WD40 REPEAT PROTEIN 12, 37 WD REPEAT-CONTAINING PROTEIN 37 HELRO|EnsemblGenome=HelroG81331|UniProtKB=T1G4D2 T1G4D2 20215930 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 system process#GO:0003008;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;muscle contraction#GO:0006936;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;muscle system process#GO:0003012;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG75858|UniProtKB=T1G2B5 T1G2B5 20215213 PTHR23070:SF255 BCS1 AAA-TYPE ATPASE MITOCHONDRIAL CHAPERONE BCS1 protein-containing complex organization#GO:0043933;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;membrane organization#GO:0061024;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;protein insertion into membrane#GO:0051205;cellular component assembly#GO:0022607;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;establishment of protein localization#GO:0045184;mitochondrial membrane organization#GO:0007006;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;protein localization to mitochondrion#GO:0070585;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG183643|UniProtKB=T1FJZ4 T1FJZ4 20209143 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;trans-synaptic signaling#GO:0099537;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG180356|UniProtKB=T1FFT4 T1FFT4 20207683 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166532|UniProtKB=T1EY78 T1EY78 20201528 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG87641|UniProtKB=T1G6T5 T1G6T5 20216782 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 19-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG168863|UniProtKB=T1F124 T1F124 20202524 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG192608|UniProtKB=T1FU45 T1FU45 20212341 PTHR10218:SF227 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA I SUBUNIT hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Opioid proenkephalin pathway#P05915>G-protein#P05994;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Opioid prodynorphin pathway#P05916>G-protein#P06002;PI3 kinase pathway#P00048>Galpha#P01199;Enkephalin release#P05913>G-Protein (i)#P05974 HELRO|EnsemblGenome=HelroG64646|UniProtKB=T1FXX4 T1FXX4 20213672 PTHR12649:SF11 PEPTIDYL-TRNA HYDROLASE 2 PEPTIDYL-TRNA HYDROLASE 2-RELATED HELRO|EnsemblGenome=HelroG84286|UniProtKB=T1G5H0 T1G5H0 20216317 PTHR13452:SF10 THUMP DOMAIN CONTAINING PROTEIN 1-RELATED THUMP DOMAIN-CONTAINING PROTEIN 1 protein-RNA adaptor activity#GO:0140517;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG195118|UniProtKB=T1FWR7 T1FWR7 20213262 PTHR12039:SF0 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine-containing compound metabolic process#GO:0072524 nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG191365|UniProtKB=T1FSX3 T1FSX3 20211920 PTHR21481:SF0 PROTEIN CLEC16A PROTEIN CLEC16A intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;regulation of autophagosome maturation#GO:1901096;establishment of localization#GO:0051234;regulation of catabolic process#GO:0009894;endosomal transport#GO:0016197;regulation of macroautophagy#GO:0016241;regulation of metabolic process#GO:0019222;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular localization#GO:0051641;localization#GO:0051179;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128 endomembrane system#GO:0012505;late endosome#GO:0005770;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endosome#GO:0005768;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG173509|UniProtKB=T1F6W9 T1F6W9 20204568 PTHR48209:SF4 AGL056WP C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188962|UniProtKB=T1FQI4 T1FQI4 20211081 PTHR24112:SF69 LEUCINE-RICH REPEAT, ISOFORM F-RELATED LEUCINE-RICH REPEAT, ISOFORM F biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;cell migration#GO:0016477;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin nucleation#GO:0051125;regulation of actin filament-based process#GO:0032970 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG186231|UniProtKB=T1FNU5 T1FNU5 20210492 PTHR23426:SF78 FERREDOXIN/ADRENODOXIN FERREDOXIN-2, MITOCHONDRIAL electron transport chain#GO:0022900;metabolic process#GO:0008152;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FDX#P04607 HELRO|EnsemblGenome=HelroG79448|UniProtKB=T1G3P0 T1G3P0 20215688 PTHR22722:SF14 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED MEGALIN, ISOFORM A hormone binding#GO:0042562;binding#GO:0005488 cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG80169|UniProtKB=T1G3Y5 T1G3Y5 20215783 PTHR10694:SF145 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4B protein demethylase activity#GO:0140457;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG62465|UniProtKB=T1FX11 T1FX11 20213359 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193653|UniProtKB=T1FV82 T1FV82 20212728 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG107927|UniProtKB=T1EEE0 T1EEE0 20194942 PTHR24390:SF271 ZINC FINGER PROTEIN FI23536P1-RELATED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG113718|UniProtKB=T1EFV6 T1EFV6 20195458 PTHR14493:SF87 UNKEMPT FAMILY MEMBER RING FINGER PROTEIN UNKEMPT HELRO|EnsemblGenome=HelroG171521|UniProtKB=T1F4D3 T1F4D3 20203682 PTHR11782:SF127 ADENOSINE/GUANOSINE DIPHOSPHATASE NUCLEOSIDE DIPHOSPHATE PHOSPHATASE ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 metabolic process#GO:0008152;nucleoside diphosphate metabolic process#GO:0009132;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate catabolic process#GO:0046434;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292 membrane#GO:0016020;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG186253|UniProtKB=T1FNV5 T1FNV5 20210502 PTHR15975:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11 post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;CCR4-NOT complex#GO:0030014 HELRO|EnsemblGenome=HelroG105492|UniProtKB=T1EDV6 T1EDV6 20194758 PTHR10984:SF85 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG180765|UniProtKB=T1FG90 T1FG90 20207839 PTHR12219:SF8 NADH-UBIQUINONE OXIDOREDUCTASE NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL cellular respiration#GO:0045333;protein-containing complex assembly#GO:0065003;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG160182|UniProtKB=T1EPX8 T1EPX8 20198628 PTHR21397:SF2 CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED BPTF-ASSOCIATED CHROMATIN COMPLEX COMPONENT 1 SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ISWI-type complex#GO:0031010;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG182758|UniProtKB=T1FIP3 T1FIP3 20208692 PTHR12027:SF101 WNT RELATED PROTEIN WNT-4 molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cell fate commitment#GO:0045165;system development#GO:0048731;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HELRO|EnsemblGenome=HelroG169322|UniProtKB=T1F1S0 T1F1S0 20202770 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178275|UniProtKB=T1FD08 T1FD08 20206707 PTHR23351:SF24 FOS TRANSCRIPTION FACTOR-RELATED ACTIVATING TRANSCRIPTION FACTOR 3-RELATED basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG181531|UniProtKB=T1FH31 T1FH31 20208130 PTHR24107:SF2 YNEIN REGULATORY COMPLEX SUBUNIT 5 NLR FAMILY CARD DOMAIN CONTAINING 3 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG161929|UniProtKB=T1ES18 T1ES18 20199368 PTHR15889:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN L37 LARGE RIBOSOMAL SUBUNIT PROTEIN ML37 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG67160|UniProtKB=T1FYX5 T1FYX5 20214023 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG174556|UniProtKB=T1F892 T1F892 20205041 PTHR12472:SF1 RAB3-GAP REGULATORY DOMAIN RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;molecular function regulator activity#GO:0098772;binding#GO:0005488;enzyme binding#GO:0019899 regulation of biological process#GO:0050789;signaling#GO:0023052;catabolic process#GO:0009056;localization within membrane#GO:0051668;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;localization#GO:0051179;cell communication#GO:0007154;cellular process#GO:0009987;autophagy#GO:0006914;establishment of protein localization#GO:0045184;synaptic signaling#GO:0099536;establishment of protein localization to membrane#GO:0090150;macroautophagy#GO:0016236;establishment of protein localization to endoplasmic reticulum#GO:0072599;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;metabolic process#GO:0008152;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594 cell junction#GO:0030054;synaptic membrane#GO:0097060;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;plasma membrane region#GO:0098590;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG193668|UniProtKB=T1FV88 T1FV88 20212734 PTHR22175:SF0 SMALL ACIDIC PROTEIN-RELATED SMALL ACIDIC PROTEIN membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG185935|UniProtKB=T1FNG5 T1FNG5 20210362 PTHR13693:SF105 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transaminase#PC00216 HELRO|EnsemblGenome=HelroG159075|UniProtKB=T1ENK0 T1ENK0 20198150 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176885|UniProtKB=T1FB06 T1FB06 20206005 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG62073|UniProtKB=T1FWV3 T1FWV3 20213301 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG110840|UniProtKB=T1EF56 T1EF56 20195208 PTHR11607:SF73 ALPHA-MANNOSIDASE ALPHA-MANNOSIDASE 2 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG76915|UniProtKB=T1G2R1 T1G2R1 20215359 PTHR13522:SF3 U6 SNRNA PHOSPHODIESTERASE 1 U6 SNRNA PHOSPHODIESTERASE 1 3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG175106|UniProtKB=T1F8V1 T1F8V1 20205250 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG117237|UniProtKB=T1EGL3 T1EGL3 20195713 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG133620|UniProtKB=T1EI17 T1EI17 20196217 PTHR24416:SF633 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR SVH-2 catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell migration#GO:0016477;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76841|UniProtKB=T1G2Q0 T1G2Q0 20215348 PTHR34924:SF1 UPF0573 PROTEIN C2ORF70 CILIARY MICROTUBULE INNER PROTEIN 2C HELRO|EnsemblGenome=HelroG105287|UniProtKB=T1EDT1 T1EDT1 20194733 PTHR45746:SF6 LP21163P LP21163P molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG126823|UniProtKB=T1EHB2 T1EHB2 20195962 PTHR13080:SF20 ATP SYNTHASE F CHAIN, MITOCHONDRIAL-RELATED ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL-RELATED channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857 nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine-containing compound metabolic process#GO:0072521;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;ATP biosynthetic process#GO:0006754;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;oxidative phosphorylation#GO:0006119;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205 respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;proton-transporting ATP synthase complex#GO:0045259;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex#GO:0016469;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG158511|UniProtKB=T1EMV9 T1EMV9 20197909 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG168289|UniProtKB=T1F0E5 T1F0E5 20202295 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG162326|UniProtKB=T1ESI3 T1ESI3 20199533 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG103993|UniProtKB=T1EDJ1 T1EDJ1 20194643 PTHR11728:SF8 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;phosphorus metabolic process#GO:0006793 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG74042|UniProtKB=T1G1L4 T1G1L4 20214962 PTHR12308:SF84 ANOCTAMIN ANOCTAMIN intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215 cellular process#GO:0009987;macromolecule localization#GO:0033036;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;membrane organization#GO:0061024;lipid transport#GO:0006869;transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG144436|UniProtKB=T1EJE6 T1EJE6 20196696 PTHR24390:SF278 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 772 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG87801|UniProtKB=T1G6V5 T1G6V5 20216802 PTHR10553:SF2 SMALL NUCLEAR RIBONUCLEOPROTEIN SMALL NUCLEAR RIBONUCLEOPROTEIN G binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397 small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;U2 snRNP#GO:0005686;P granule#GO:0043186;U5 snRNP#GO:0005682;nuclear protein-containing complex#GO:0140513;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;SMN-Sm protein complex#GO:0034719;nucleus#GO:0005634;U1 snRNP#GO:0005685;ribonucleoprotein granule#GO:0035770;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;catalytic step 2 spliceosome#GO:0071013;U12-type spliceosomal complex#GO:0005689;U4 snRNP#GO:0005687;intracellular membrane-bounded organelle#GO:0043231;U2-type prespliceosome#GO:0071004;cytoplasmic ribonucleoprotein granule#GO:0036464;spliceosomal tri-snRNP complex#GO:0097526;catalytic complex#GO:1902494;precatalytic spliceosome#GO:0071011;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG185432|UniProtKB=T1FMT5 T1FMT5 20210134 PTHR11256:SF50 BCL-2 RELATED APOPTOSIS REGULATOR CED-9 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;release of cytochrome c from mitochondria#GO:0001836;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG178761|UniProtKB=T1FDP4 T1FDP4 20206943 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED translation regulator activity#GO:0045182 negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG190617|UniProtKB=T1FS52 T1FS52 20211649 PTHR24161:SF130 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG109381|UniProtKB=T1EET0 T1EET0 20195082 PTHR13055:SF12 TUMOR ENDOTHELIAL MARKER 7 RELATED LETHAL (1) G0289, ISOFORM D HELRO|EnsemblGenome=HelroG190425|UniProtKB=T1FRZ5 T1FRZ5 20211592 PTHR47385:SF14 CALPONIN TRANSGELIN actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 HELRO|EnsemblGenome=HelroG194177|UniProtKB=T1FVS2 T1FVS2 20212918 PTHR45614:SF315 MYB PROTEIN-RELATED MYB PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;mitotic cell cycle#GO:0000278;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cell cycle#GO:0007049;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG186154|UniProtKB=T1FNQ8 T1FNQ8 20210455 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG193432|UniProtKB=T1FUZ3 T1FUZ3 20212639 PTHR12830:SF9 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of organelle organization#GO:0010638;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of cellular component organization#GO:0051130;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;protein K11-linked ubiquitination#GO:0070979;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;protein polyubiquitination#GO:0000209;regulation of organelle organization#GO:0033043;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of chromosome segregation#GO:0051983;positive regulation of mitotic nuclear division#GO:0045840;regulation of chromosome separation#GO:1905818;protein ubiquitination#GO:0016567;regulation of cell cycle process#GO:0010564;proteasomal protein catabolic process#GO:0010498;positive regulation of cell cycle#GO:0045787;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;catabolic process#GO:0009056;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;positive regulation of mitotic cell cycle#GO:0045931;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of chromosome organization#GO:0033044;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of nuclear division#GO:0051783;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG87779|UniProtKB=T1G6V3 T1G6V3 20216800 PTHR11955:SF157 FATTY ACID BINDING PROTEIN LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN lipid binding#GO:0008289;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;ion binding#GO:0043167;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;binding#GO:0005488 macromolecule localization#GO:0033036;lipid transport#GO:0006869;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;fatty acid transport#GO:0015908;localization#GO:0051179 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG185220|UniProtKB=T1FMI8 T1FMI8 20210037 PTHR11835:SF84 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;alcohol metabolic process#GO:0006066;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG67348|UniProtKB=T1FZ00 T1FZ00 20214048 PTHR14226:SF29 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER NEUROPATHY TARGET ESTERASE SWS hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 hydrolase#PC00121;esterase#PC00097 HELRO|EnsemblGenome=HelroG185077|UniProtKB=T1FMD3 T1FMD3 20209982 PTHR47979:SF139 DRAB11-RELATED SMALL MONOMERIC GTPASE guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;localization#GO:0051179;regulation of transport#GO:0051049;regulation of localization#GO:0032879;transport#GO:0006810;regulation of endocytosis#GO:0030100 intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG63815|UniProtKB=T1FXK8 T1FXK8 20213556 PTHR10585:SF14 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR signal sequence receptor activity#GO:0005048 cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;protein localization to organelle#GO:0033365;localization#GO:0051179 cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG77635|UniProtKB=T1G313 T1G313 20215461 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG182865|UniProtKB=T1FIW2 T1FIW2 20208761 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188682|UniProtKB=T1FQ90 T1FQ90 20210987 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190415|UniProtKB=T1FRZ2 T1FRZ2 20211589 PTHR19211:SF15 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2 nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ATP binding#GO:0005524;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG172578|UniProtKB=T1F5J7 T1F5J7 20204096 PTHR24393:SF190 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG108539|UniProtKB=T1EEK1 T1EEK1 20195003 PTHR22594:SF16 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARAGINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG63549|UniProtKB=T1FXH3 T1FXH3 20213521 PTHR10343:SF84 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 protein-binding activity modulator#PC00095;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG189723|UniProtKB=T1FRA7 T1FRA7 20211354 PTHR45872:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D signaling receptor binding#GO:0005102;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;G protein-coupled receptor binding#GO:0001664;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG76554|UniProtKB=T1G2L5 T1G2L5 20215313 PTHR21230:SF1 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED GOLGI SNAP RECEPTOR COMPLEX MEMBER 2-RELATED SNAP receptor activity#GO:0005484;protein binding#GO:0005515;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488 cellular component organization#GO:0016043;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;vesicle fusion#GO:0006906;membrane organization#GO:0061024;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 membrane traffic protein#PC00150;SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG83813|UniProtKB=T1G5A7 T1G5A7 20216254 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183537|UniProtKB=T1FJT4 T1FJT4 20209083 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG138584|UniProtKB=T1EIV8 T1EIV8 20196508 PTHR12547:SF190 CCCH ZINC FINGER/TIS11-RELATED PROTEIN TIS11 molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517;translation regulator activity#GO:0045182;mRNA 3'-UTR binding#GO:0003730;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;RNA binding#GO:0003723 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG87050|UniProtKB=T1G6L0 T1G6L0 20216707 PTHR24416:SF620 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR TORSO transmembrane signaling receptor activity#GO:0004888;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76399|UniProtKB=T1G2J7 T1G2J7 20215295 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG107963|UniProtKB=T1EEE4 T1EEE4 20194946 PTHR45759:SF1 NUCLEOLAR GTP-BINDING PROTEIN 1 GTP-BINDING PROTEIN 4 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;RNA binding#GO:0003723;hydrolase activity#GO:0016787 cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG176953|UniProtKB=T1FB24 T1FB24 20206023 PTHR14195:SF2 G PATCH DOMAIN CONTAINING PROTEIN 2 GH10944P nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG64107|UniProtKB=T1FXP3 T1FXP3 20213591 PTHR13398:SF0 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG63872|UniProtKB=T1FXL4 T1FXL4 20213562 PTHR11849:SF190 ETS ETS-DOMAIN PROTEIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG164412|UniProtKB=T1EVE2 T1EVE2 20200542 PTHR11850:SF421 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG70319|UniProtKB=T1G046 T1G046 20214444 PTHR31898:SF1 TRANSMEMBRANE PROTEIN 136 TLC DOMAIN-CONTAINING PROTEIN 5 HELRO|EnsemblGenome=HelroG73100|UniProtKB=T1G1A0 T1G1A0 20214848 PTHR23516:SF23 SAM (S-ADENOSYL METHIONINE) TRANSPORTER MOLYBDATE-ANION TRANSPORTER transporter#PC00227 HELRO|EnsemblGenome=HelroG73702|UniProtKB=T1G1H4 T1G1H4 20214922 PTHR43330:SF7 METHIONINE AMINOPEPTIDASE METHIONINE AMINOPEPTIDASE 1 metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG108549|UniProtKB=T1EEK3 T1EEK3 20195005 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG enzyme activator activity#GO:0008047;binding#GO:0005488;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;protein metabolic process#GO:0019538;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of metabolic process#GO:0009893;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;proteasomal protein catabolic process#GO:0010498;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG192325|UniProtKB=T1FTU0 T1FTU0 20212237 PTHR24006:SF747 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG163542|UniProtKB=T1EU65 T1EU65 20200115 PTHR20873:SF0 L-SERYL-TRNA(SEC) KINASE L-SERYL-TRNA(SEC) KINASE binding#GO:0005488;nucleic acid binding#GO:0003676;tRNA binding#GO:0000049;RNA binding#GO:0003723;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG156770|UniProtKB=T1EM07 T1EM07 20197607 PTHR11834:SF0 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED PROTEIN SCALLOPED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 developmental process#GO:0032502;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;animal gross anatomical part developmental process#GO:0160108;embryonic organ development#GO:0048568;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG171057|UniProtKB=T1F3R9 T1F3R9 20203468 PTHR24127:SF1 ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG62279|UniProtKB=T1FWY5 T1FWY5 20213333 PTHR24075:SF6 SEC63 DOMAIN-CONTAINING ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;DNA helicase activity#GO:0003678;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;ATP-dependent activity, acting on DNA#GO:0008094 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172053|UniProtKB=T1F4Z3 T1F4Z3 20203892 PTHR13034:SF2 DYNACTIN P62 SUBUNIT DYNACTIN SUBUNIT 4 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;transport#GO:0006810 actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG165973|UniProtKB=T1EXI8 T1EXI8 20201288 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG112873|UniProtKB=T1EFM7 T1EFM7 20195379 PTHR11777:SF9 ALANYL-TRNA SYNTHETASE ALANINE--TRNA LIGASE, CYTOPLASMIC carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;deacylase activity#GO:0160215;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG185502|UniProtKB=T1FMW5 T1FMW5 20210164 PTHR43563:SF14 AMINE OXIDASE AMINE OXIDASE oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG176502|UniProtKB=T1FAL3 T1FAL3 20205862 PTHR12558:SF13 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 27 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 protein modification process#GO:0036211;primary metabolic process#GO:0044238;cell cycle#GO:0007049;cell division#GO:0051301;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;mitotic cell cycle phase transition#GO:0044772;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of chromosome organization#GO:0033044;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;mitotic cell cycle process#GO:1903047;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;metaphase/anaphase transition of mitotic cell cycle#GO:0007091;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of chromosome segregation#GO:0051983;metaphase/anaphase transition of cell cycle#GO:0044784 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;cytoplasm#GO:0005737;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178665|UniProtKB=T1FDJ0 T1FDJ0 20206889 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 mRNA splicing#P00058>U5#P01474 HELRO|EnsemblGenome=HelroG174271|UniProtKB=T1F7X2 T1F7X2 20204921 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173390|UniProtKB=T1F6R6 T1F6R6 20204515 PTHR19288:SF93 4-NITROPHENYLPHOSPHATASE-RELATED FI11325P-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG66738|UniProtKB=T1FYQ2 T1FYQ2 20213950 PTHR20855:SF152 ADIPOR/PROGESTIN RECEPTOR-RELATED ADIPONECTIN RECEPTOR PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;cytokine-mediated signaling pathway#GO:0019221;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163980|UniProtKB=T1EUP9 T1EUP9 20200299 PTHR28584:SF1 FAMILY WITH SEQUENCE SIMILARITY 228 MEMBER A PROTEIN FAM228A HELRO|EnsemblGenome=HelroG159291|UniProtKB=T1ENU5 T1ENU5 20198245 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG171817|UniProtKB=T1F4Q7 T1F4Q7 20203806 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG184185|UniProtKB=T1FKQ6 T1FKQ6 20209405 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG183590|UniProtKB=T1FJW2 T1FJW2 20209111 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107639|UniProtKB=T1EEB8 T1EEB8 20194920 PTHR21581:SF34 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12 cytoplasm#GO:0005737;TRAPP complex#GO:0030008;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG95422|UniProtKB=T1G957 T1G957 20217604 PTHR43829:SF27 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-3 channel activity#GO:0015267;carbohydrate transmembrane transporter activity#GO:0015144;passive transmembrane transporter activity#GO:0022803;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643;transport#GO:0006810;fluid transport#GO:0042044;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;water transport#GO:0006833;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG67993|UniProtKB=T1FZ91 T1FZ91 20214139 PTHR12233:SF2 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26C macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166364|UniProtKB=T1EY22 T1EY22 20201472 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG190836|UniProtKB=T1FSC5 T1FSC5 20211722 PTHR23116:SF39 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED DYSCHRONIC, ISOFORM G cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG110863|UniProtKB=T1EF58 T1EF58 20195210 PTHR11133:SF28 SACCHAROPINE DEHYDROGENASE ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG83215|UniProtKB=T1G522 T1G522 20216170 PTHR11711:SF31 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE 5 binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein#PC00020 HELRO|EnsemblGenome=HelroG171429|UniProtKB=T1F496 T1F496 20203645 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194423|UniProtKB=T1FW15 T1FW15 20213011 PTHR16487:SF0 PPP4R2-RELATED PROTEIN SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2 molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG161965|UniProtKB=T1ES35 T1ES35 20199385 PTHR11139:SF134 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE MTOR phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 TOR signaling#GO:0031929;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;negative regulation of macroautophagy#GO:0016242;signal transduction#GO:0007165;regulation of catabolic process#GO:0009894;regulation of macroautophagy#GO:0016241;negative regulation of autophagy#GO:0010507;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;TORC2 signaling#GO:0038203;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;TORC1 signaling#GO:0038202;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;negative regulation of catabolic process#GO:0009895 intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;TOR complex#GO:0038201;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway by glucose deprivation#P04397>mTOR#P04638;PDGF signaling pathway#P00047>mTOR#P01144;Interleukin signaling pathway#P00036>mTOR#P00966;Hypoxia response via HIF activation#P00030>TOR#P00817 HELRO|EnsemblGenome=HelroG115658|UniProtKB=T1EG98 T1EG98 20195600 PTHR42886:SF96 RE40534P-RELATED 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ABHD5 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;acyltransferase activity#GO:0016746;lipase activity#GO:0016298 glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;phosphorus metabolic process#GO:0006793;organophosphate biosynthetic process#GO:0090407 intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG85304|UniProtKB=T1G5V2 T1G5V2 20216449 PTHR45617:SF165 LEUCINE RICH REPEAT FAMILY PROTEIN COMMON DPR-INTERACTING PROTEIN-RELATED scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TLR#P01346 HELRO|EnsemblGenome=HelroG146952|UniProtKB=T1EJV8 T1EJV8 20196858 PTHR23310:SF77 ACYL-COA-BINDING PROTEIN, ACBP LD25952P heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 small molecule metabolic process#GO:0044281;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG89804|UniProtKB=T1G7H9 T1G7H9 20217026 PTHR45810:SF17 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG157568|UniProtKB=T1EMD2 T1EMD2 20197732 PTHR11652:SF14 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG67040|UniProtKB=T1FYV6 T1FYV6 20214004 PTHR24235:SF34 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR 11-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG170184|UniProtKB=T1F2R7 T1F2R7 20203116 PTHR19302:SF13 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 2 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;microtubule nucleation#GO:0007020;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;cytoplasmic microtubule organization#GO:0031122;reproductive process#GO:0022414 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG174733|UniProtKB=T1F8F1 T1F8F1 20205100 PTHR19378:SF7 GOLGIN- RELATED HAUS AUGMIN-LIKE COMPLEX SUBUNIT 3 microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;organelle#GO:0043226;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652 HELRO|EnsemblGenome=HelroG101151|UniProtKB=T1ED33 T1ED33 20194485 PTHR10635:SF0 COATOMER SUBUNIT BETA COATOMER SUBUNIT BETA endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987 Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;COPI-coated vesicle#GO:0030137;cytoplasm#GO:0005737;vesicle coat#GO:0030120;intracellular organelle#GO:0043229;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG160114|UniProtKB=T1EPT7 T1EPT7 20198587 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191328|UniProtKB=T1FSW1 T1FSW1 20211908 PTHR22654:SF2 G PROTEIN PATHWAY SUPPRESSOR 2 G PROTEIN PATHWAY SUPPRESSOR 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG84628|UniProtKB=T1G5L1 T1G5L1 20216358 PTHR11267:SF106 T-BOX PROTEIN-RELATED T-RELATED PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG160466|UniProtKB=T1EQA2 T1EQA2 20198752 PTHR21501:SF1 PROTEIN FAM-161 PROTEIN FAM-161 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782 HELRO|EnsemblGenome=HelroG184840|UniProtKB=T1FM26 T1FM26 20209875 PTHR13664:SF0 BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR molecular function regulator activity#GO:0098772;protein-membrane adaptor activity#GO:0043495;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 response to stress#GO:0006950;cellular component biogenesis#GO:0044085;response to nutrient levels#GO:0031667;organelle organization#GO:0006996;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein-containing complex disassembly#GO:0032984;organelle localization#GO:0051640;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;cellular component disassembly#GO:0022411;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033 membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;transferase complex#GO:1990234;phagophore assembly site#GO:0000407;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;extrinsic component of membrane#GO:0019898;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;phosphatidylinositol 3-kinase complex, class III#GO:0035032;transferase complex, transferring phosphorus-containing groups#GO:0061695;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76166|UniProtKB=T1G2G0 T1G2G0 20215258 PTHR10155:SF10 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PI3K21B, ISOFORM B enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to peptide hormone stimulus#GO:0071375;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to hormone#GO:0009725 transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898;membrane protein complex#GO:0098796;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 kinase modulator#PC00140 Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway feedback loops 2#P04398>PI3K#P04661;p53 pathway#P00059>PI3K#P04609;Angiogenesis#P00005>PI3K#P00236;VEGF signaling pathway#P00056>PI3K#P01413;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Integrin signalling pathway#P00034>PI3K#P00936 HELRO|EnsemblGenome=HelroG139499|UniProtKB=T1EIZ0 T1EIZ0 20196540 PTHR19297:SF192 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3-RELATED glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG104861|UniProtKB=T1EDP0 T1EDP0 20194692 PTHR16515:SF19 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 14 ISOFORM X1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG64965|UniProtKB=T1FY21 T1FY21 20213719 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987 asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;synaptic membrane#GO:0097060 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG106613|UniProtKB=T1EE37 T1EE37 20194839 PTHR17613:SF14 CEREBRAL PROTEIN-11-RELATED DEMENTIN, ISOFORM H cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG66187|UniProtKB=T1FYI3 T1FYI3 20213881 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182683|UniProtKB=T1FIK8 T1FIK8 20208657 PTHR47027:SF30 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184329|UniProtKB=T1FL05 T1FL05 20209504 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG176720|UniProtKB=T1FAT9 T1FAT9 20205938 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG139434|UniProtKB=T1EIY8 T1EIY8 20196538 PTHR22762:SF54 ALPHA-GLUCOSIDASE GLUCOSIDASE II SUBUNIT ALPHA hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;glucosidase activity#GO:0015926;catalytic activity#GO:0003824 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058 glucosidase#PC00108 HELRO|EnsemblGenome=HelroG111074|UniProtKB=T1EF76 T1EF76 20195228 PTHR12315:SF0 BICOID-INTERACTING PROTEIN RELATED 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME RNA binding#GO:0003723;snRNA binding#GO:0017069;methyltransferase activity#GO:0008168;binding#GO:0005488;nucleic acid binding#GO:0003676;O-methyltransferase activity#GO:0008171;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;snRNA metabolic process#GO:0016073;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 HELRO|EnsemblGenome=HelroG167782|UniProtKB=T1EZS8 T1EZS8 20202078 PTHR10910:SF62 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN AT07585P-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251;RNA binding#GO:0003723;hydrolase activity#GO:0016787;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on RNA#GO:0140098 adenosine to inosine editing#GO:0006382;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;base conversion or substitution editing#GO:0016553;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192112|UniProtKB=T1FTL2 T1FTL2 20212159 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG145634|UniProtKB=T1EJL4 T1EJL4 20196764 PTHR11945:SF866 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;histone deacetylase binding#GO:0042826;sequence-specific double-stranded DNA binding#GO:1990837;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;Oxidative stress response#P00046>MEF-2#P01128 HELRO|EnsemblGenome=HelroG194076|UniProtKB=T1FVN1 T1FVN1 20212877 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG167728|UniProtKB=T1EZQ5 T1EZQ5 20202055 PTHR10838:SF34 SYNAPTOGYRIN SYNAPTOGYRIN cell junction#GO:0030054;secretory vesicle#GO:0099503;presynapse#GO:0098793;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG75878|UniProtKB=T1G2C0 T1G2C0 20215218 PTHR11075:SF54 PEPTIDE CHAIN RELEASE FACTOR LARGE RIBOSOMAL SUBUNIT PROTEIN ML62 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;translation factor activity#GO:0180051;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689 translation release factor#PC00225 HELRO|EnsemblGenome=HelroG116969|UniProtKB=T1EGI9 T1EGI9 20195691 PTHR12450:SF22 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN KINASE FAM20C-LIKE ISOFORM X1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184333|UniProtKB=T1FL07 T1FL07 20209506 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71489|UniProtKB=T1G0M2 T1G0M2 20214620 PTHR45723:SF1 SERINE/THREONINE-PROTEIN KINASE RIO1 SERINE_THREONINE-PROTEIN KINASE RIO3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 cytosol#GO:0005829;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG73106|UniProtKB=T1G1A3 T1G1A3 20214851 PTHR28630:SF35 FAMILY NOT NAMED PEROXIREDOXIN-LIKE 2A intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG68442|UniProtKB=T1FZE8 T1FZE8 20214196 PTHR24416:SF639 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;kinase activity#GO:0016301;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cellular response to nerve growth factor stimulus#GO:1990090;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 axon#GO:0030424;signaling receptor complex#GO:0043235;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184437|UniProtKB=T1FL74 T1FL74 20209573 PTHR24125:SF5 ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE HELRO|EnsemblGenome=HelroG177643|UniProtKB=T1FBZ9 T1FBZ9 20206348 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112893|UniProtKB=T1EFN0 T1EFN0 20195382 PTHR12124:SF47 POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED EXOSOME COMPLEX COMPONENT 10 HELRO|EnsemblGenome=HelroG100536|UniProtKB=T1ED02 T1ED02 20194454 PTHR45664:SF22 PROTEIN ZERKNUELLT 1-RELATED HOMEOTIC PROTEIN BICOID-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG184994|UniProtKB=T1FM88 T1FM88 20209937 PTHR13509:SF26 SEC61 SUBUNIT BETA PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of protein localization to endoplasmic reticulum#GO:0072599;intracellular transport#GO:0046907;protein targeting to membrane#GO:0006612;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;intracellular protein localization#GO:0008104;protein targeting#GO:0006605;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;localization within membrane#GO:0051668;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;post-translational protein targeting to membrane, translocation#GO:0031204 membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;rough endoplasmic reticulum#GO:0005791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG193942|UniProtKB=T1FVI2 T1FVI2 20212828 PTHR23208:SF36 LYSOZYME PROTEIN GH FAMILY 25 LYSOZYME 2-RELATED cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG132162|UniProtKB=T1EHX3 T1EHX3 20196173 PTHR10887:SF419 DNA2/NAM7 HELICASE FAMILY RNA HELICASE MOV10L1 ISOFORM X1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulatory ncRNA-mediated gene silencing#GO:0031047;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG175922|UniProtKB=T1F9W3 T1F9W3 20205612 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87564|UniProtKB=T1G6S3 T1G6S3 20216770 PTHR21266:SF62 IRON-SULFUR DOMAIN CONTAINING PROTEIN CHOLESTEROL 7-DESATURASE NVD oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG110029|UniProtKB=T1EEY4 T1EEY4 20195136 PTHR11328:SF51 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12 L-amino acid transmembrane transporter activity#GO:0015179;neutral L-amino acid transmembrane transporter activity#GO:0015175;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 nitrogen compound transport#GO:0071705;L-alpha-amino acid transmembrane transport#GO:1902475;L-amino acid transport#GO:0015807;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;establishment of localization#GO:0051234;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG190193|UniProtKB=T1FRR9 T1FRR9 20211516 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;animal gross anatomical part developmental process#GO:0160108;mRNA stabilization#GO:0048255;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;multicellular organism development#GO:0007275;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of RNA stability#GO:0043487;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of RNA catabolic process#GO:1902369;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66158|UniProtKB=T1FYH6 T1FYH6 20213874 PTHR10652:SF26 ADENYLYL CYCLASE-ASSOCIATED PROTEIN ADENYLYL CYCLASE-ASSOCIATED PROTEIN binding#GO:0005488;enzyme binding#GO:0019899;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;developmental process#GO:0032502;anatomical structure development#GO:0048856;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG181610|UniProtKB=T1FH62 T1FH62 20208161 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG176254|UniProtKB=T1FAC2 T1FAC2 20205771 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG65834|UniProtKB=T1FYD2 T1FYD2 20213830 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG157038|UniProtKB=T1EM51 T1EM51 20197651 PTHR13162:SF8 CCR4-NOT TRANSCRIPTION COMPLEX CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1 regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008 supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;CCR4-NOT complex#GO:0030014;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;P-body#GO:0000932;intracellular organelle#GO:0043229 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG65285|UniProtKB=T1FY54 T1FY54 20213752 PTHR19302:SF14 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 3 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 sexual reproduction#GO:0019953;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cell cycle process#GO:0022402;microtubule nucleation#GO:0007020;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;cytoplasmic microtubule organization#GO:0031122;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG142985|UniProtKB=T1EJ83 T1EJ83 20196633 PTHR45902:SF1 LATROPHILIN RECEPTOR-LIKE PROTEIN A LATROPHILIN RECEPTOR-LIKE PROTEIN A transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG71899|UniProtKB=T1G0S7 T1G0S7 20214675 PTHR11753:SF5 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG65068|UniProtKB=T1FY28 T1FY28 20213726 PTHR45942:SF1 Calcineurin subunit B PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B, ALPHA molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;phosphatase binding#GO:0019902 biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;calcineurin-mediated signaling#GO:0097720;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;cell communication#GO:0007154 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG75178|UniProtKB=T1G222 T1G222 20215120 PTHR19850:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1 signaling receptor complex adaptor activity#GO:0030159;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796 G-protein#PC00020;heterotrimeric G-protein#PC00117;protein-binding activity modulator#PC00095 Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;PI3 kinase pathway#P00048>Gbetagamma#P01188;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458 HELRO|EnsemblGenome=HelroG81610|UniProtKB=T1G4G3 T1G4G3 20215961 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG182345|UniProtKB=T1FI35 T1FI35 20208484 PTHR34192:SF10 PLASTOCYANIN MAJOR ISOFORM, CHLOROPLASTIC-RELATED PLASTOCYANIN MAJOR ISOFORM, CHLOROPLASTIC-RELATED HELRO|EnsemblGenome=HelroG112317|UniProtKB=T1EFI5 T1EFI5 20195337 PTHR11347:SF206 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of signaling#GO:0023056;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG87750|UniProtKB=T1G6V2 T1G6V2 20216799 PTHR23084:SF263 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED MORN REPEAT-CONTAINING PROTEIN 1 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG189098|UniProtKB=T1FQN0 T1FQN0 20211127 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG177298|UniProtKB=T1FBH0 T1FBH0 20206169 PTHR13720:SF14 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG99303|UniProtKB=T1G9S1 T1G9S1 20217817 PTHR11142:SF5 PSEUDOURIDYLATE SYNTHASE TRNA PSEUDOURIDINE(38_39) SYNTHASE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 pseudouridine synthesis#GO:0001522;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA modification#GO:0016556;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 lyase#PC00144 HELRO|EnsemblGenome=HelroG95199|UniProtKB=T1G950 T1G950 20217597 PTHR11871:SF0 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;cytosol#GO:0005829 protein modifying enzyme#PC00260;protein phosphatase#PC00195 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG191511|UniProtKB=T1FT20 T1FT20 20211967 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165128|UniProtKB=T1EWB3 T1EWB3 20200863 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99725|UniProtKB=T1G9U9 T1G9U9 20217845 PTHR10555:SF170 SORTING NEXIN FI18122P1 binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167 cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;retromer complex#GO:0030904;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG108850|UniProtKB=T1EEN0 T1EEN0 20195032 PTHR45688:SF18 FAMILY NOT NAMED ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE HELRO|EnsemblGenome=HelroG193692|UniProtKB=T1FV95 T1FV95 20212741 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG167033|UniProtKB=T1EYX5 T1EYX5 20201775 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG169885|UniProtKB=T1F2E6 T1F2E6 20202996 PTHR16172:SF2 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE JET FUEL, ISOFORM A membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG94192|UniProtKB=T1G8Z2 T1G8Z2 20217539 PTHR45832:SF8 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG191543|UniProtKB=T1FT24 T1FT24 20211971 PTHR23090:SF9 NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;pyridine-containing compound metabolic process#GO:0072524;oxoacid metabolic process#GO:0043436;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine nucleotide metabolic process#GO:0006163;indole-containing compound metabolic process#GO:0042430;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ligase#PC00142 HELRO|EnsemblGenome=HelroG192215|UniProtKB=T1FTP9 T1FTP9 20212196 PTHR16861:SF11 GLYCOPROTEIN 38 GPI ANCHORED PROTEIN biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG73656|UniProtKB=T1G1G9 T1G1G9 20214917 PTHR12216:SF3 UROCANATE HYDRATASE UROCANATE HYDRATASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 hydratase#PC00120 HELRO|EnsemblGenome=HelroG96068|UniProtKB=T1G9A0 T1G9A0 20217647 PTHR10048:SF118 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;cell motility#GO:0048870;regulation of cellular process#GO:0050794;phosphatidylinositol phosphate biosynthetic process#GO:0046854;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;intracellular signaling cassette#GO:0141124;glycerophospholipid metabolic process#GO:0006650;cell migration#GO:0016477;lipid biosynthetic process#GO:0008610;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 kinase#PC00137 Axon guidance mediated by netrin#P00009>PI3K#P00363;Integrin signalling pathway#P00034>PI3K#P00936;p53 pathway feedback loops 2#P04398>PI3K#P04661;PDGF signaling pathway#P00047>PI3K#P01168;Apoptosis signaling pathway#P00006>PI3K#P00310;Ras Pathway#P04393>PI3K#P04567;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Hypoxia response via HIF activation#P00030>PI3K#P00823;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;PI3 kinase pathway#P00048>P110ACT#P01177;VEGF signaling pathway#P00056>PI3K#P01413;PI3 kinase pathway#P00048>p110#P01192;FGF signaling pathway#P00021>PI3K#P00640;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;EGF receptor signaling pathway#P00018>PI3K#P00557;Angiogenesis#P00005>PI3K#P00236 HELRO|EnsemblGenome=HelroG108467|UniProtKB=T1EEJ4 T1EEJ4 20194996 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Cell cycle#P00013>Protein kinase subunit#P00482;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035 HELRO|EnsemblGenome=HelroG66461|UniProtKB=T1FYL4 T1FYL4 20213912 PTHR48012:SF10 STERILE20-LIKE KINASE, ISOFORM B-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG136785|UniProtKB=T1EIF8 T1EIF8 20196358 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523 cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HELRO|EnsemblGenome=HelroG182124|UniProtKB=T1FHS8 T1FHS8 20208377 PTHR23345:SF15 VITELLOGENIN-RELATED VITELLOGENIN-6 molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 storage protein#PC00210 HELRO|EnsemblGenome=HelroG132567|UniProtKB=T1EHY9 T1EHY9 20196189 PTHR24241:SF161 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG85561|UniProtKB=T1G5Z2 T1G5Z2 20216489 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789 cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HELRO|EnsemblGenome=HelroG171770|UniProtKB=T1F4N0 T1F4N0 20203779 PTHR47027:SF30 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152254|UniProtKB=T1EKQ2 T1EKQ2 20197152 PTHR12276:SF115 EPSIN/ENT-RELATED FI19443P1 protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897 intracellular organelle#GO:0043229;endosome#GO:0005768;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136;clathrin-coated vesicle membrane#GO:0030665;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;plasma membrane#GO:0005886;cytoplasm#GO:0005737 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG164469|UniProtKB=T1EVG5 T1EVG5 20200565 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174965|UniProtKB=T1F8N6 T1F8N6 20205185 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER IP12869P monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943 monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG186041|UniProtKB=T1FNL0 T1FNL0 20210407 PTHR11702:SF43 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED GTP-BINDING PROTEIN 10 ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG89295|UniProtKB=T1G7B7 T1G7B7 20216964 PTHR48071:SF37 SRCR DOMAIN-CONTAINING PROTEIN SRCR DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152141|UniProtKB=T1EKP6 T1EKP6 20197146 PTHR12357:SF140 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN protein-RNA adaptor activity#GO:0140517;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;RNA binding#GO:0003723 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG158693|UniProtKB=T1EN47 T1EN47 20197997 PTHR15176:SF1 NEPHROCYSTIN NEPHROCYSTIN-1 cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;localization#GO:0051179;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;organelle assembly#GO:0070925 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;ciliary base#GO:0097546;membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG67237|UniProtKB=T1FYY5 T1FYY5 20214033 PTHR10553:SF44 SMALL NUCLEAR RIBONUCLEOPROTEIN U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;U6 snRNP#GO:0005688;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG164998|UniProtKB=T1EW35 T1EW35 20200785 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178718|UniProtKB=T1FDM4 T1FDM4 20206923 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81226|UniProtKB=T1G4B6 T1G4B6 20215914 PTHR13265:SF0 THO COMPLEX SUBUNIT 1 HPR1 establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription export complex#GO:0000346;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG105012|UniProtKB=T1EDP8 T1EDP8 20194700 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843 transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG177646|UniProtKB=T1FC02 T1FC02 20206351 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG171382|UniProtKB=T1F477 T1F477 20203626 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN CC8L18.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG90454|UniProtKB=T1G7R6 T1G7R6 20217113 PTHR19300:SF65 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174768|UniProtKB=T1F8G0 T1F8G0 20205109 PTHR12582:SF50 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC-5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HELRO|EnsemblGenome=HelroG100131|UniProtKB=T1ECY8 T1ECY8 20194440 PTHR23308:SF74 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE 1 protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;protein serine/threonine phosphatase inhibitor activity#GO:0004865;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888 cell projection morphogenesis#GO:0048858;positive regulation of BMP signaling pathway#GO:0030513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;axonogenesis#GO:0007409;neuron development#GO:0048666;positive regulation of signaling#GO:0023056;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of BMP signaling pathway#GO:0030510;axon development#GO:0061564;axon guidance#GO:0007411;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092 nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;membraneless organelle#GO:0043228 RNA splicing factor#PC00148 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HELRO|EnsemblGenome=HelroG126217|UniProtKB=T1EH89 T1EH89 20195939 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regionalization#GO:0003002;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG189847|UniProtKB=T1FRF2 T1FRF2 20211399 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG168120|UniProtKB=T1F069 T1F069 20202219 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64996|UniProtKB=T1FY23 T1FY23 20213721 PTHR23138:SF87 RAN BINDING PROTEIN RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 1 nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;nucleocytoplasmic transport#GO:0006913;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 organelle envelope#GO:0031967;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77557|UniProtKB=T1G2Z8 T1G2Z8 20215446 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG87481|UniProtKB=T1G6Q8 T1G6Q8 20216755 PTHR11742:SF6 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194761|UniProtKB=T1FWD9 T1FWD9 20213134 PTHR42757:SF48 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell-cell adhesion#GO:0098609 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG193656|UniProtKB=T1FV85 T1FV85 20212731 PTHR10910:SF62 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN AT07585P-RELATED hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA binding#GO:0003723;hydrolase activity#GO:0016787;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;adenosine to inosine editing#GO:0006382;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194025|UniProtKB=T1FVL0 T1FVL0 20212856 PTHR12461:SF104 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 5 tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;dioxygenase activity#GO:0051213;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on RNA#GO:0140098;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165164|UniProtKB=T1EWD0 T1EWD0 20200880 PTHR24042:SF5 NEL HOMOLOG PROTEIN KINASE C-BINDING PROTEIN NELL1-LIKE PROTEIN calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG66732|UniProtKB=T1FYP9 T1FYP9 20213947 PTHR12290:SF19 CORNICHON-RELATED PROTEIN CORNICHON HOMOLOG 4 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG78878|UniProtKB=T1G3G6 T1G3G6 20215614 PTHR11157:SF17 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 6 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG188636|UniProtKB=T1FQ73 T1FQ73 20210970 PTHR19282:SF544 TETRASPANIN TETRASPANIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG95818|UniProtKB=T1G978 T1G978 20217625 PTHR10615:SF82 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT8 protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;NSL complex#GO:0044545;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG187961|UniProtKB=T1FPI3 T1FPI3 20210730 PTHR12790:SF0 TRANSCRIPTION INITIATION FACTOR IA RRN3 RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription by RNA polymerase I#GO:0006360;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription initiation at RNA polymerase I promoter#GO:0006361;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HELRO|EnsemblGenome=HelroG123898|UniProtKB=T1EGZ6 T1EGZ6 20195846 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 HELRO|EnsemblGenome=HelroG172169|UniProtKB=T1F539 T1F539 20203938 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG179012|UniProtKB=T1FE20 T1FE20 20207069 PTHR31334:SF1 SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045 HELRO|EnsemblGenome=HelroG182719|UniProtKB=T1FIN0 T1FIN0 20208679 PTHR13454:SF11 PROTEIN MCM10 HOMOLOG PROTEIN MCM10 HOMOLOG DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;single-stranded DNA binding#GO:0003697;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260 replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG106737|UniProtKB=T1EE44 T1EE44 20194846 PTHR11042:SF185 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED WEE1-LIKE PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG183048|UniProtKB=T1FJ38 T1FJ38 20208837 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164028|UniProtKB=T1EUS8 T1EUS8 20200328 PTHR23050:SF552 CALCIUM BINDING PROTEIN AT16150P-RELATED molecular function regulator activity#GO:0098772;cation binding#GO:0043169;enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;T cell activation#P00053>Calmodulin#P01305;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG72943|UniProtKB=T1G175 T1G175 20214823 PTHR12300:SF197 HVA22-LIKE PROTEINS LP05237P-RELATED protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum tubular network organization#GO:0071786 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;cytoplasmic microtubule#GO:0005881;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;endoplasmic reticulum tubular network#GO:0071782;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;organelle membrane#GO:0031090;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;endoplasmic reticulum#GO:0005783;cytoskeleton#GO:0005856;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166754|UniProtKB=T1EYG9 T1EYG9 20201619 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193450|UniProtKB=T1FUZ9 T1FUZ9 20212645 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG176694|UniProtKB=T1FAS6 T1FAS6 20205925 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE MGP4 glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG159892|UniProtKB=T1EPI3 T1EPI3 20198483 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG67865|UniProtKB=T1FZ66 T1FZ66 20214114 PTHR19282:SF452 TETRASPANIN LD03691P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156800|UniProtKB=T1EM13 T1EM13 20197613 PTHR13110:SF0 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3 LSM3 HOMOLOG, U6 SMALL NUCLEAR RNA AND MRNA DEGRADATION ASSOCIATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;U4/U6 x U5 tri-snRNP complex#GO:0046540;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;P-body#GO:0000932;spliceosomal tri-snRNP complex#GO:0097526;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG68917|UniProtKB=T1FZL3 T1FZL3 20214261 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG157165|UniProtKB=T1EM74 T1EM74 20197674 PTHR19134:SF542 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;synaptic membrane adhesion#GO:0099560;synapse organization#GO:0050808;cell adhesion#GO:0007155;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172268|UniProtKB=T1F562 T1F562 20203961 PTHR45805:SF2 NUCLEAR HORMONE RECEPTOR HR3-RELATED NUCLEAR HORMONE RECEPTOR HR3-RELATED sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG144825|UniProtKB=T1EJG7 T1EJG7 20196717 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177933|UniProtKB=T1FCH4 T1FCH4 20206523 PTHR13128:SF12 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36 protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular localization#GO:0051641;protein transport#GO:0015031;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;late endosome membrane#GO:0031902;endomembrane system#GO:0012505;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74348|UniProtKB=T1G1P8 T1G1P8 20214996 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176525|UniProtKB=T1FAM2 T1FAM2 20205871 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN YEATS DOMAIN-CONTAINING PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90460|UniProtKB=T1G7R7 T1G7R7 20217114 PTHR11847:SF4 RIBOSOMAL PROTEIN L15 LARGE RIBOSOMAL SUBUNIT PROTEIN EL15 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG112528|UniProtKB=T1EFK5 T1EFK5 20195357 PTHR21329:SF3 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG67628|UniProtKB=T1FZ31 T1FZ31 20214079 PTHR11909:SF520 CASEIN KINASE-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056 cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>Casein kinase I#P01242;Wnt signaling pathway#P00057>Casein Kinase 1#P01460 HELRO|EnsemblGenome=HelroG164302|UniProtKB=T1EV86 T1EV86 20200486 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193178|UniProtKB=T1FUP8 T1FUP8 20212544 PTHR23309:SF58 3-HYDROXYACYL-COA DEHYROGENASE 3-HYDROXYACYL-COA DEHYDROGENASE NAD BINDING DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG193466|UniProtKB=T1FV09 T1FV09 20212655 PTHR45632:SF40 LD33804P KELCH-LIKE PROTEIN 12 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162287|UniProtKB=T1ESG4 T1ESG4 20199514 PTHR10480:SF12 PROTEIN UNC-13 HOMOLOG UNC-13, ISOFORM E binding#GO:0005488;SNARE binding#GO:0000149;calmodulin binding#GO:0005516;syntaxin binding#GO:0019905;protein binding#GO:0005515 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG178411|UniProtKB=T1FD49 T1FD49 20206748 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG70906|UniProtKB=T1G0E1 T1G0E1 20214539 PTHR11011:SF129 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753 intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG176884|UniProtKB=T1FB05 T1FB05 20206004 PTHR33562:SF20 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN SLEEPLESS HELRO|EnsemblGenome=HelroG128168|UniProtKB=T1EHL5 T1EHL5 20196065 PTHR23235:SF183 KRUEPPEL-LIKE TRANSCRIPTION FACTOR DENDRITIC ARBOR REDUCTION PROTEIN 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG142574|UniProtKB=T1EJ62 T1EJ62 20196612 PTHR13174:SF3 D-GLUCURONYL C5-EPIMERASE D-GLUCURONYL C5-EPIMERASE isomerase activity#GO:0016853;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;catalytic activity#GO:0003824;racemase and epimerase activity#GO:0016854 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 isomerase#PC00135 HELRO|EnsemblGenome=HelroG191255|UniProtKB=T1FST1 T1FST1 20211878 PTHR12708:SF0 DNA POLYMERASE EPSILON SUBUNIT B DNA POLYMERASE EPSILON SUBUNIT 2 response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA synthesis involved in DNA replication#GO:0090592;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;translesion synthesis#GO:0019985;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;epsilon DNA polymerase complex#GO:0008622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG92165|UniProtKB=T1G8C6 T1G8C6 20217323 PTHR24208:SF127 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN AWH DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG192435|UniProtKB=T1FTY6 T1FTY6 20212283 PTHR12618:SF20 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG181207|UniProtKB=T1FGQ7 T1FGQ7 20208006 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG145234|UniProtKB=T1EJJ5 T1EJJ5 20196745 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168546|UniProtKB=T1F0P7 T1F0P7 20202397 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE establishment or maintenance of cell polarity#GO:0007163;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;mitotic cell cycle#GO:0000278;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG72062|UniProtKB=T1G0U8 T1G0U8 20214696 PTHR24329:SF543 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN CEH-17 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG95592|UniProtKB=T1G969 T1G969 20217616 PTHR47966:SF86 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987 aspartic protease#PC00053;protease#PC00190 HELRO|EnsemblGenome=HelroG184072|UniProtKB=T1FKJ1 T1FKJ1 20209340 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191273|UniProtKB=T1FST9 T1FST9 20211886 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG81674|UniProtKB=T1G4H3 T1G4H3 20215971 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG180690|UniProtKB=T1FG63 T1FG63 20207812 PTHR14725:SF0 RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED HELRO|EnsemblGenome=HelroG181748|UniProtKB=T1FHA1 T1FHA1 20208200 PTHR12653:SF0 NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5 cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;electron transport chain#GO:0022900;metabolic process#GO:0008152;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091 respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190087|UniProtKB=T1FRP0 T1FRP0 20211487 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG163610|UniProtKB=T1EUA1 T1EUA1 20200151 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178297|UniProtKB=T1FD21 T1FD21 20206720 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE cellular localization#GO:0051641;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656;mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;regulation of establishment or maintenance of cell polarity#GO:0032878;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG63114|UniProtKB=T1FXB1 T1FXB1 20213459 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG154433|UniProtKB=T1ELE8 T1ELE8 20197398 PTHR21250:SF0 PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG65544|UniProtKB=T1FY93 T1FY93 20213791 PTHR12874:SF29 F-BOX ONLY PROTEIN 48-RELATED F-BOX ONLY PROTEIN 9 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;SCF ubiquitin ligase complex#GO:0019005;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG157436|UniProtKB=T1EMB5 T1EMB5 20197715 PTHR45673:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;calcineurin-mediated signaling#GO:0097720 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737 protein phosphatase#PC00195 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG70944|UniProtKB=T1G0E7 T1G0E7 20214545 PTHR11845:SF13 5'-DEOXYNUCLEOTIDASE HDDC2 5'-DEOXYNUCLEOTIDASE HDDC2 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG85923|UniProtKB=T1G644 T1G644 20216541 PTHR23427:SF1 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 4 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG182535|UniProtKB=T1FIB8 T1FIB8 20208567 PTHR19282:SF511 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182783|UniProtKB=T1FIQ3 T1FIQ3 20208702 PTHR21224:SF1 INTEGRATOR COMPLEX SUBUNIT 1 INTEGRATOR COMPLEX SUBUNIT 1 RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;DNA-templated transcription#GO:0006351;catabolic process#GO:0009056;DNA-templated transcription initiation#GO:0006352;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound catabolic process#GO:0034655;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;integrator complex#GO:0032039;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG171110|UniProtKB=T1F3T7 T1F3T7 20203486 PTHR13333:SF5 M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG192051|UniProtKB=T1FTJ6 T1FTJ6 20212143 PTHR13269:SF6 NUCLEOPORIN NDC1 NUCLEOPORIN NDC1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;nuclear pore organization#GO:0006999;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG190480|UniProtKB=T1FS09 T1FS09 20211606 PTHR15067:SF5 E3 UBIQUITIN-PROTEIN LIGASE RNF8 E3 UBIQUITIN-PROTEIN LIGASE AMFR ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 post-translational protein modification#GO:0043687;biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein K48-linked ubiquitination#GO:0070936;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;intracellular signal transduction#GO:0035556;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cell communication#GO:0007154;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;protein ubiquitination#GO:0016567;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;response to unfolded protein#GO:0006986;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG87327|UniProtKB=T1G6P1 T1G6P1 20216738 PTHR13318:SF292 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6, ISOFORM A-RELATED primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG168105|UniProtKB=T1F062 T1F062 20202212 PTHR28597:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 negative regulation of biological process#GO:0048519;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of transport#GO:0051051;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of secretion#GO:0051046;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG132660|UniProtKB=T1EHZ0 T1EHZ0 20196190 PTHR22722:SF14 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED MEGALIN, ISOFORM A binding#GO:0005488;hormone binding#GO:0042562 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 HELRO|EnsemblGenome=HelroG181423|UniProtKB=T1FGZ9 T1FGZ9 20208098 PTHR34914:SF1 LYMPHOCYTE EXPANSION MOLECULE CILIARY MICROTUBULE-ASSOCIATED PROTEIN 2 HELRO|EnsemblGenome=HelroG193697|UniProtKB=T1FV98 T1FV98 20212744 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180209|UniProtKB=T1FFK6 T1FFK6 20207605 PTHR45761:SF1 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylcholine binding#GO:0031210;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169;lipid binding#GO:0008289 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG86403|UniProtKB=T1G6B7 T1G6B7 20216614 PTHR10760:SF18 TORSIN LD13476P-RELATED response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;response to misfolded protein#GO:0051788;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to misfolded protein#GO:0071218;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967 chaperone#PC00072 Parkinson disease#P00049>Torsin A#P01221 HELRO|EnsemblGenome=HelroG144672|UniProtKB=T1EJF8 T1EJF8 20196708 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG164840|UniProtKB=T1EVV4 T1EVV4 20200704 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185724|UniProtKB=T1FN72 T1FN72 20210270 PTHR22957:SF686 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN GROWTH HORMONE-REGULATED TBC PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG190526|UniProtKB=T1FS26 T1FS26 20211623 PTHR24213:SF9 ACTIN-BINDING LIM PROTEIN UNCOORDINATED 115A, ISOFORM B-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;lamellipodium assembly#GO:0030032;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 Axon guidance mediated by netrin#P00009>Ablim#P00358 HELRO|EnsemblGenome=HelroG99567|UniProtKB=T1G9T7 T1G9T7 20217833 PTHR12320:SF98 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE PTC7 HOMOLOG regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG172826|UniProtKB=T1F5Z4 T1F5Z4 20204243 PTHR11388:SF157 ORGANIC ANION TRANSPORTER ORGANIC ANION TRANSPORTING POLYPEPTIDE 30B, ISOFORM A active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178 transporter#PC00227 HELRO|EnsemblGenome=HelroG98421|UniProtKB=T1G9M6 T1G9M6 20217772 PTHR47958:SF26 ATP-DEPENDENT RNA HELICASE DBP3 EUKARYOTIC INITIATION FACTOR 4A-III nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 organelle lumen#GO:0043233;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG105366|UniProtKB=T1EDU1 T1EDU1 20194743 PTHR47958:SF216 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657 sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG161457|UniProtKB=T1ERH6 T1ERH6 20199176 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158780|UniProtKB=T1EN91 T1EN91 20198041 PTHR21255:SF23 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 1-LIKE protein binding#GO:0005515;binding#GO:0005488 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;dynein complex#GO:0030286;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG166174|UniProtKB=T1EXV3 T1EXV3 20201403 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 kinase inhibitor activity#GO:0019210;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;guanyl-nucleotide exchange factor activity#GO:0005085 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164908|UniProtKB=T1EVY5 T1EVY5 20200735 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192425|UniProtKB=T1FTY2 T1FTY2 20212279 PTHR15283:SF4 GREMLIN 1 CTCK DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine binding#GO:0019955;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG185838|UniProtKB=T1FNC8 T1FNC8 20210325 PTHR31400:SF1 GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1 PROTEIN GUCD1 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG99945|UniProtKB=T1G9V7 T1G9V7 20217853 PTHR11616:SF333 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 transport#GO:0006810;amino acid transport#GO:0006865;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG65956|UniProtKB=T1FYF0 T1FYF0 20213848 PTHR15574:SF40 WD REPEAT DOMAIN-CONTAINING FAMILY WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;regulation of lipid biosynthetic process#GO:0046890;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;regulation of metabolic process#GO:0019222;regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;negative regulation of cellular process#GO:0048523 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG157527|UniProtKB=T1EMC5 T1EMC5 20197725 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;primary active transmembrane transporter activity#GO:0015399;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transport#GO:0006811;potassium ion homeostasis#GO:0055075;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;export from cell#GO:0140352;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG181717|UniProtKB=T1FH91 T1FH91 20208190 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88624|UniProtKB=T1G745 T1G745 20216892 PTHR23123:SF38 PHD/F-BOX CONTAINING PROTEIN JMJC DOMAIN-CONTAINING PROTEIN-RELATED histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG181430|UniProtKB=T1FH02 T1FH02 20208101 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG160945|UniProtKB=T1EQW4 T1EQW4 20198964 PTHR12752:SF9 PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN KRAMER, ISOFORM I HELRO|EnsemblGenome=HelroG193502|UniProtKB=T1FV23 T1FV23 20212669 PTHR12447:SF31 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 LD31969P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;late endosome#GO:0005770;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188933|UniProtKB=T1FQH9 T1FQH9 20211076 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG192839|UniProtKB=T1FUC5 T1FUC5 20212421 PTHR24115:SF0 KINESIN-RELATED FI21273P1-RELATED protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based process#GO:0007017;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG193220|UniProtKB=T1FUR6 T1FUR6 20212562 PTHR20338:SF7 NUCLEAR RESPIRATORY FACTOR 1 MISEXPRESSION SUPPRESSOR OF RAS 3, ISOFORM B RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG163700|UniProtKB=T1EUD2 T1EUD2 20200182 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191164|UniProtKB=T1FSP2 T1FSP2 20211839 PTHR24416:SF349 TYROSINE-PROTEIN KINASE RECEPTOR INACTIVE TYROSINE-PROTEIN KINASE RYK transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169235|UniProtKB=T1F1M0 T1F1M0 20202720 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164053|UniProtKB=T1EUU3 T1EUU3 20200343 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164895|UniProtKB=T1EVX7 T1EVX7 20200727 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG141773|UniProtKB=T1EJ41 T1EJ41 20196591 PTHR24229:SF103 NEUROPEPTIDES RECEPTOR ALLATOSTATIN A RECEPTOR 1, ISOFORM B peptide binding#GO:0042277;neuropeptide binding#GO:0042923;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG183398|UniProtKB=T1FJK5 T1FJK5 20209004 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190259|UniProtKB=T1FRT8 T1FRT8 20211535 PTHR15744:SF0 BLOM7 KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;mRNA splice site recognition#GO:0006376;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG192188|UniProtKB=T1FTN8 T1FTN8 20212185 PTHR16011:SF0 IFT57/HIPPI INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;non-motile cilium assembly#GO:1905515;localization#GO:0051179 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;Golgi apparatus#GO:0005794;cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 structural protein#PC00211 Huntington disease#P00029>Hip-12#P00763;Huntington disease#P00029>Hippi#P00794 HELRO|EnsemblGenome=HelroG183140|UniProtKB=T1FJ70 T1FJ70 20208869 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155996|UniProtKB=T1ELQ6 T1ELQ6 20197506 PTHR11452:SF95 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;galactosidase#PC00104 HELRO|EnsemblGenome=HelroG168148|UniProtKB=T1F081 T1F081 20202231 PTHR47577:SF4 THAP DOMAIN-CONTAINING PROTEIN 6 TRANSPOSABLE ELEMENT P TRANSPOSASE-LIKE RNASE H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109728|UniProtKB=T1EEW0 T1EEW0 20195112 PTHR24335:SF4 MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN EXTRA-EXTRA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;central nervous system development#GO:0007417 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG80970|UniProtKB=T1G477 T1G477 20215875 PTHR13693:SF3 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE C-PALMITOYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;ceramide metabolic process#GO:0006672;sphingoid biosynthetic process#GO:0046520 protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 transaminase#PC00216 HELRO|EnsemblGenome=HelroG103856|UniProtKB=T1EDH9 T1EDH9 20194631 PTHR11599:SF44 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;proteasome complex#GO:0000502;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG177326|UniProtKB=T1FBI1 T1FBI1 20206180 PTHR31199:SF1 ARPIN ARPIN negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;negative regulation of cytoskeleton organization#GO:0051494;regulation of actin filament organization#GO:0110053;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125 HELRO|EnsemblGenome=HelroG107560|UniProtKB=T1EEB2 T1EEB2 20194914 PTHR23255:SF109 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;protein binding#GO:0005515;kinase activity#GO:0016301;transforming growth factor beta receptor activity#GO:0005024;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;regionalization#GO:0003002;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;dorsal/ventral pattern formation#GO:0009953;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cellular response to growth factor stimulus#GO:0071363;pattern specification process#GO:0007389 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 serine/threonine protein kinase receptor#PC00205 BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;GBB signaling pathway#P06214>SAX#P06307;SCW signaling pathway#P06216>SAX#P06329;DPP-SCW signaling pathway#P06212>SAX#P06274;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278 HELRO|EnsemblGenome=HelroG158516|UniProtKB=T1EMW3 T1EMW3 20197913 PTHR47020:SF1 HILLARIN HILLARIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG128981|UniProtKB=T1EHR0 T1EHR0 20196110 PTHR11255:SF109 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE ETA phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 neutral lipid metabolic process#GO:0006638;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;biological regulation#GO:0065007;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;signal transduction#GO:0007165;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metabolite interconversion enzyme#PC00262;kinase#PC00137 HELRO|EnsemblGenome=HelroG163440|UniProtKB=T1EU19 T1EU19 20200069 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG173995|UniProtKB=T1F7G6 T1F7G6 20204765 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85646|UniProtKB=T1G611 T1G611 20216508 PTHR14604:SF8 WD40 REPEAT PF20 SPERM-ASSOCIATED ANTIGEN 16 PROTEIN organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoskeleton#GO:0005856;axonemal central apparatus#GO:1990716;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG159507|UniProtKB=T1EP41 T1EP41 20198341 PTHR20932:SF8 LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 1-RELATED HELRO|EnsemblGenome=HelroG79655|UniProtKB=T1G3R8 T1G3R8 20215716 PTHR47611:SF1 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64615|UniProtKB=T1FXX0 T1FXX0 20213668 PTHR23138:SF190 RAN BINDING PROTEIN E3 SUMO-PROTEIN LIGASE RANBP2 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein localization to organelle#GO:0033365;protein transport#GO:0015031;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191698|UniProtKB=T1FT79 T1FT79 20212026 PTHR24409:SF422 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG163309|UniProtKB=T1ETW2 T1ETW2 20200012 PTHR14399:SF5 P53-INDUCED PROTEIN RELATED TRANSMEMBRANE PROTEIN 47 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell-cell junction#GO:0005911 HELRO|EnsemblGenome=HelroG170668|UniProtKB=T1F3A9 T1F3A9 20203308 PTHR12461:SF99 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7 catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;hydrolase activity#GO:0016787 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68300|UniProtKB=T1FZC8 T1FZC8 20214176 PTHR11886:SF35 DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN 1, CYTOPLASMIC-RELATED protein binding#GO:0005515;binding#GO:0005488 cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG160108|UniProtKB=T1EPT1 T1EPT1 20198581 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186045|UniProtKB=T1FNL2 T1FNL2 20210409 PTHR45752:SF212 LEUCINE-RICH REPEAT-CONTAINING CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182017|UniProtKB=T1FHL6 T1FHL6 20208315 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194786|UniProtKB=T1FWE8 T1FWE8 20213143 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG166859|UniProtKB=T1EYN3 T1EYN3 20201683 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165002|UniProtKB=T1EW37 T1EW37 20200787 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152427|UniProtKB=T1EKR8 T1EKR8 20197168 PTHR24333:SF20 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX DOMAIN-CONTAINING PROTEIN homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG75376|UniProtKB=T1G242 T1G242 20215140 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 HELRO|EnsemblGenome=HelroG163511|UniProtKB=T1EU57 T1EU57 20200107 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG85838|UniProtKB=T1G633 T1G633 20216530 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 protein binding#GO:0005515;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488 secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;signaling#GO:0023052;export from cell#GO:0140352;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;exocytosis#GO:0006887;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;neurotransmitter transport#GO:0006836;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;synaptic signaling#GO:0099536;regulation of exocytosis#GO:0017157;localization#GO:0051179;cell communication#GO:0007154;regulation of secretion#GO:0051046;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular vesicle#GO:0097708;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;axon#GO:0030424;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG115562|UniProtKB=T1EG93 T1EG93 20195595 PTHR45700:SF3 UBIQUITIN-PROTEIN LIGASE E3C UBIQUITIN-PROTEIN LIGASE E3B catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG74895|UniProtKB=T1G1X4 T1G1X4 20215072 PTHR43272:SF111 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;anatomical structure development#GO:0048856;system development#GO:0048731;oxoacid metabolic process#GO:0043436;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nucleobase-containing compound metabolic process#GO:0006139;nervous system development#GO:0007399;organophosphate metabolic process#GO:0019637;long-chain fatty acid metabolic process#GO:0001676;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;neurogenesis#GO:0022008;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;neuron differentiation#GO:0030182;developmental process#GO:0032502;lipid metabolic process#GO:0006629 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lipid droplet#GO:0005811;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 ligase#PC00142 HELRO|EnsemblGenome=HelroG150875|UniProtKB=T1EKH7 T1EKH7 20197077 PTHR31340:SF3 MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1 MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1 exonuclease activity#GO:0004527;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;5'-3' exonuclease activity#GO:0008409;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;catalytic activity#GO:0003824;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;DNA exonuclease activity#GO:0004529;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519 HELRO|EnsemblGenome=HelroG114203|UniProtKB=T1EG00 T1EG00 20195502 PTHR11675:SF101 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG77715|UniProtKB=T1G330 T1G330 20215478 PTHR24055:SF616 MITOGEN-ACTIVATED PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 signaling#GO:0023052;response to stimulus#GO:0050896;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;cellular component assembly#GO:0022607;establishment of localization in cell#GO:0051649;signal transduction#GO:0007165;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;organelle assembly#GO:0070925;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG100124|UniProtKB=T1ECY7 T1ECY7 20194439 PTHR12661:SF5 PETER PAN-RELATED SUPPRESSOR OF SWI4 1 HOMOLOG RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843 rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 preribosome, large subunit precursor#GO:0030687;protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG113006|UniProtKB=T1EFP5 T1EFP5 20195397 PTHR10048:SF7 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;catalytic activity#GO:0003824;transferase activity#GO:0016740 phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;vacuole organization#GO:0007033;intracellular signal transduction#GO:0035556;localization#GO:0051179;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;organelle assembly#GO:0070925;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macroautophagy#GO:0016236;lipid biosynthetic process#GO:0008610;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;pexophagy#GO:0000425;establishment of localization#GO:0051234;glycerophospholipid biosynthetic process#GO:0046474;transport#GO:0006810;lipid metabolic process#GO:0006629;signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;endocytosis#GO:0006897;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;process utilizing autophagic mechanism#GO:0061919;phosphatidylinositol phosphate biosynthetic process#GO:0046854;cellular component assembly#GO:0022607;glycerophospholipid metabolic process#GO:0006650;autophagy#GO:0006914;signal transduction#GO:0007165;autophagosome organization#GO:1905037;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;metabolic process#GO:0008152 cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;microbody#GO:0042579;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;transferase complex#GO:1990234;phagophore assembly site#GO:0000407;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;peroxisome#GO:0005777;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endosome#GO:0005768;phosphatidylinositol 3-kinase complex, class III#GO:0035032;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase#PC00137 p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;Angiogenesis#P00005>PI3K#P00236;PDGF signaling pathway#P00047>PI3K#P01168;Ras Pathway#P04393>PI3K#P04567;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;EGF receptor signaling pathway#P00018>PI3K#P00557;FGF signaling pathway#P00021>PI3K#P00640;p53 pathway feedback loops 2#P04398>PI3K#P04661;T cell activation#P00053>PI3K#P01322;VEGF signaling pathway#P00056>PI3K#P01413;Integrin signalling pathway#P00034>PI3K#P00936 HELRO|EnsemblGenome=HelroG63069|UniProtKB=T1FXA7 T1FXA7 20213455 PTHR22914:SF42 CHITIN SYNTHASE CHITIN SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375 metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;chitin metabolic process#GO:0006030;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;aminoglycan biosynthetic process#GO:0006023;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;amino sugar metabolic process#GO:0006040;biosynthetic process#GO:0009058 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transferase#PC00220 HELRO|EnsemblGenome=HelroG96397|UniProtKB=T1G9B8 T1G9B8 20217665 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG86442|UniProtKB=T1G6C3 T1G6C3 20216620 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN 84-LIKE sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG179215|UniProtKB=T1FED2 T1FED2 20207181 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158201|UniProtKB=T1EMK4 T1EMK4 20197804 PTHR18919:SF107 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG192804|UniProtKB=T1FUB3 T1FUB3 20212409 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG77866|UniProtKB=T1G349 T1G349 20215497 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH19970P-RELATED secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804 sodium ion transport#GO:0006814;transport#GO:0006810;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG67484|UniProtKB=T1FZ14 T1FZ14 20214062 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG79183|UniProtKB=T1G3L2 T1G3L2 20215660 PTHR10290:SF3 DNA TOPOISOMERASE I DNA TOPOISOMERASE 1 DNA topoisomerase#PC00017;DNA metabolism protein#PC00009 DNA replication#P00017>DNA Topisomerase#P00536;DNA replication#P00017>Top#P00530 HELRO|EnsemblGenome=HelroG94572|UniProtKB=T1G918 T1G918 20217565 PTHR11647:SF1 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE dihydropyrimidinase activity#GO:0004157;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;primary metabolic process#GO:0044238;pyrimidine nucleobase catabolic process#GO:0006208;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;pyrimidine nucleobase metabolic process#GO:0006206;metabolic process#GO:0008152 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HELRO|EnsemblGenome=HelroG142649|UniProtKB=T1EJ66 T1EJ66 20196616 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG188139|UniProtKB=T1FPP3 T1FPP3 20210790 PTHR11256:SF47 BCL-2 RELATED BCL-2-LIKE PROTEIN 10 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968 Apoptosis signaling pathway#P00006>Diva#P00285 HELRO|EnsemblGenome=HelroG162956|UniProtKB=T1ETF2 T1ETF2 20199852 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163896|UniProtKB=T1EUL2 T1EUL2 20200262 PTHR24406:SF42 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191658|UniProtKB=T1FT67 T1FT67 20212014 PTHR12865:SF1 PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2 lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle organization#GO:0006996;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;endomembrane system organization#GO:0010256;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vesicle organization#GO:0016050;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;phosphorus metabolic process#GO:0006793;Golgi organization#GO:0007030;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;plasma membrane#GO:0005886;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG194641|UniProtKB=T1FW97 T1FW97 20213093 PTHR12269:SF1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER transporter#PC00227 HELRO|EnsemblGenome=HelroG63904|UniProtKB=T1FXM2 T1FXM2 20213570 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;cell fate specification#GO:0001708;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG185174|UniProtKB=T1FMG9 T1FMG9 20210018 PTHR14205:SF15 WD-REPEAT PROTEIN EARP AND GARP COMPLEX-INTERACTING PROTEIN 1 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446 HELRO|EnsemblGenome=HelroG153326|UniProtKB=T1EL39 T1EL39 20197289 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62983|UniProtKB=T1FX89 T1FX89 20213437 PTHR23030:SF39 PCD6 INTERACTING PROTEIN-RELATED PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179;cell division#GO:0051301;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;cell cycle#GO:0007049;mitotic cytokinesis#GO:0000281;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;mitotic cell cycle process#GO:1903047;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cytokinesis#GO:0000910;protein transport#GO:0015031;cellular localization#GO:0051641;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;establishment of protein localization to vacuole#GO:0072666;intracellular protein transport#GO:0006886;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG193315|UniProtKB=T1FUV5 T1FUV5 20212601 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG141211|UniProtKB=T1EJ30 T1EJ30 20196580 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;action potential#GO:0001508;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG186207|UniProtKB=T1FNT5 T1FNT5 20210482 PTHR10683:SF44 TRANSALDOLASE TRANSALDOLASE transaldolase activity#GO:0004801;transketolase or transaldolase activity#GO:0016744;catalytic activity#GO:0003824;transferase activity#GO:0016740 generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;glyceraldehyde-3-phosphate metabolic process#GO:0019682;pentose-phosphate shunt#GO:0006098;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;pentose-phosphate shunt, non-oxidative branch#GO:0009052;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 lyase#PC00144;aldolase#PC00044;metabolite interconversion enzyme#PC00262 Pentose phosphate pathway#P02762>Transaldolase#P03081 HELRO|EnsemblGenome=HelroG109167|UniProtKB=T1EEQ8 T1EEQ8 20195060 PTHR13847:SF294 SARCOSINE DEHYDROGENASE-RELATED FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG145945|UniProtKB=T1EJP1 T1EJP1 20196791 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177261|UniProtKB=T1FBF1 T1FBF1 20206150 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164249|UniProtKB=T1EV58 T1EV58 20200458 PTHR20899:SF1 PIERCE HOMOLOG PIERCER OF MICROTUBULE WALL 1 PROTEIN HELRO|EnsemblGenome=HelroG121592|UniProtKB=T1EGS5 T1EGS5 20195775 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG116521|UniProtKB=T1EGF5 T1EGF5 20195657 PTHR22957:SF497 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN ECOTROPIC VIRAL INTEGRATION SITE 5 ORTHOLOG enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG163508|UniProtKB=T1EU54 T1EU54 20200104 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;membrane#GO:0016020 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188428|UniProtKB=T1FPZ3 T1FPZ3 20210890 PTHR11256:SF64 BCL-2 RELATED AT16536P passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267 cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;release of cytochrome c from mitochondria#GO:0001836;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG186652|UniProtKB=T1FP19 T1FP19 20210566 PTHR11588:SF13 TUBULIN TUBULIN EPSILON CHAIN ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG64425|UniProtKB=T1FXU5 T1FXU5 20213643 PTHR15938:SF0 TBP-1 INTERACTING PROTEIN HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;enzyme regulator activity#GO:0030234;double-stranded DNA binding#GO:0003690;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772 meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;nucleobase-containing compound metabolic process#GO:0006139;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;homologous recombination#GO:0035825;reproductive process#GO:0022414;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;reciprocal homologous recombination#GO:0140527;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;homologous chromosome pairing at meiosis#GO:0007129;organelle organization#GO:0006996;cellular process#GO:0009987;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402 condensed chromosome#GO:0000793;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 General transcription by RNA polymerase I#P00022>TBP#P00657;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399;General transcription regulation#P00023>TBP#P00670;General transcription by RNA polymerase I#P00022>SL1 complex#P00653 HELRO|EnsemblGenome=HelroG182953|UniProtKB=T1FIZ3 T1FIZ3 20208792 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG171557|UniProtKB=T1F4E6 T1F4E6 20203695 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG95018|UniProtKB=T1G942 T1G942 20217589 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG170715|UniProtKB=T1F3C5 T1F3C5 20203324 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG82034|UniProtKB=T1G4M2 T1G4M2 20216020 PTHR45638:SF4 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3-RELATED nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;monoatomic cation transmembrane transporter activity#GO:0008324;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 system process#GO:0003008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;sensory perception#GO:0007600;nervous system process#GO:0050877;transport#GO:0006810;sensory perception of chemical stimulus#GO:0007606;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141;ion channel#PC00133 HELRO|EnsemblGenome=HelroG104718|UniProtKB=T1EDN3 T1EDN3 20194685 PTHR12709:SF4 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG166878|UniProtKB=T1EYP4 T1EYP4 20201694 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108901|UniProtKB=T1EEN6 T1EEN6 20195038 PTHR32546:SF25 G-PROTEIN COUPLED RECEPTOR 158-RELATED MIP05539P transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG192960|UniProtKB=T1FUG5 T1FUG5 20212461 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;nucleoside phosphate binding#GO:1901265;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;regulation of carbohydrate metabolic process#GO:0006109;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;cellular response to stress#GO:0033554;regulation of carbohydrate biosynthetic process#GO:0043255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG115085|UniProtKB=T1EG62 T1EG62 20195564 PTHR23257:SF992 SERINE-THREONINE PROTEIN KINASE SCAFFOLD PROTEIN ILK kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG121903|UniProtKB=T1EGT1 T1EGT1 20195781 PTHR24241:SF117 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE S RECEPTOR-LIKE transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG113813|UniProtKB=T1EFX1 T1EFX1 20195473 PTHR43311:SF2 GLUTAMATE--TRNA LIGASE NONDISCRIMINATING GLUTAMYL-TRNA SYNTHETASE EARS2, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 aminoacyl-tRNA synthetase#PC00047 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG83646|UniProtKB=T1G587 T1G587 20216234 PTHR12360:SF16 NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1 TRANSCRIPTIONAL REPRESSOR NF-X1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG103179|UniProtKB=T1EDE8 T1EDE8 20194600 PTHR31873:SF6 L-ASPARTATE DEHYDROGENASE-RELATED ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG158356|UniProtKB=T1EMP4 T1EMP4 20197844 PTHR21321:SF1 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP40 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;snRNA processing#GO:0016180;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;snRNA metabolic process#GO:0016073;rRNA processing#GO:0006364;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;snRNA 3'-end processing#GO:0034472;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;maturation of 5.8S rRNA#GO:0000460;negative regulation of gene expression#GO:0010629;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG166778|UniProtKB=T1EYI5 T1EYI5 20201635 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG89090|UniProtKB=T1G784 T1G784 20216931 PTHR45981:SF11 LD02310P LD02310P catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;MHC protein binding#GO:0042287;acyltransferase activity#GO:0016746;signaling receptor binding#GO:0005102;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 protein modification by small protein conjugation or removal#GO:0070647;immune system process#GO:0002376;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;antigen processing and presentation#GO:0019882;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;immune response#GO:0006955;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;early endosome membrane#GO:0031901;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72786|UniProtKB=T1G156 T1G156 20214804 PTHR11878:SF76 SODIUM/CALCIUM EXCHANGER CALX-BETA DOMAIN-CONTAINING PROTEIN secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;homeostatic process#GO:0042592;export from cell#GO:0140352;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG167014|UniProtKB=T1EYW5 T1EYW5 20201765 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105142|UniProtKB=T1EDR3 T1EDR3 20194715 PTHR11467:SF189 HISTONE H1 HISTONE 24 chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;chromatin DNA binding#GO:0031490 regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG162732|UniProtKB=T1ET25 T1ET25 20199725 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG158761|UniProtKB=T1EN82 T1EN82 20198032 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168899|UniProtKB=T1F141 T1F141 20202541 PTHR24033:SF193 EGF-LIKE DOMAIN-CONTAINING PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8 HELRO|EnsemblGenome=HelroG75694|UniProtKB=T1G291 T1G291 20215189 PTHR11829:SF388 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN CROCODILE transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG161598|UniProtKB=T1ERP2 T1ERP2 20199242 PTHR12352:SF3 SECRETED MODULAR CALCIUM-BINDING PROTEIN NIDOGEN-2 cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG62336|UniProtKB=T1FWZ7 T1FWZ7 20213345 PTHR43658:SF15 SHORT-CHAIN DEHYDROGENASE/REDUCTASE 3-HYDROXYACYL-COA DEHYDROGENASE TYPE-2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;hormone metabolic process#GO:0042445;small molecule metabolic process#GO:0044281;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG166723|UniProtKB=T1EYF6 T1EYF6 20201606 PTHR21704:SF18 NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED NIPPED-B PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 mitotic cell cycle#GO:0000278;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;sister chromatid cohesion#GO:0007062;localization#GO:0051179;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;mitotic sister chromatid cohesion#GO:0007064;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;response to stimulus#GO:0050896;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization#GO:0016043;cellular response to stress#GO:0033554;cellular process#GO:0009987;establishment of protein localization#GO:0045184;response to stress#GO:0006950;organelle organization#GO:0006996;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG192005|UniProtKB=T1FTI1 T1FTI1 20212128 PTHR34756:SF1 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3 HELRO|EnsemblGenome=HelroG110679|UniProtKB=T1EF42 T1EF42 20195194 PTHR24092:SF150 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE intramembrane lipid carrier activity#GO:0140303;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;ATPase-coupled intramembrane lipid carrier activity#GO:0140326 cellular process#GO:0009987;macromolecule localization#GO:0033036;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;lipid transport#GO:0006869;transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG185708|UniProtKB=T1FN64 T1FN64 20210262 PTHR23064:SF71 TROPONIN EF-HAND DOMAIN-CONTAINING PROTEIN actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG192823|UniProtKB=T1FUC1 T1FUC1 20212417 PTHR16121:SF0 CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG186296|UniProtKB=T1FNY0 T1FNY0 20210527 PTHR12862:SF0 BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN N-ACETYL-D-GLUCOSAMINE KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG162063|UniProtKB=T1ES76 T1ES76 20199426 PTHR47533:SF4 PROTEIN CBG21859 AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87445|UniProtKB=T1G6Q2 T1G6Q2 20216749 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;nuclear transport#GO:0051169;nuclear export#GO:0051168 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG96557|UniProtKB=T1G9C9 T1G9C9 20217676 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE lyase activity#GO:0016829;molecular transducer activity#GO:0060089;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653 cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG92327|UniProtKB=T1G8E5 T1G8E5 20217342 PTHR11143:SF7 60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER RIBOSOMAL PROTEIN L26 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG191185|UniProtKB=T1FSQ1 T1FSQ1 20211848 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to heat#GO:0009408;response to stress#GO:0006950;protein refolding#GO:0042026;protein metabolic process#GO:0019538;protein folding#GO:0006457;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG70657|UniProtKB=T1G0A0 T1G0A0 20214498 PTHR43146:SF1 CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG94331|UniProtKB=T1G901 T1G901 20217548 PTHR23074:SF17 AAA DOMAIN-CONTAINING FIDGETIN-LIKE PROTEIN 1 ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG66198|UniProtKB=T1FYI4 T1FYI4 20213882 PTHR24044:SF506 NOTCH LIGAND FAMILY MEMBER PROTEIN EYES SHUT HOMOLOG protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG192813|UniProtKB=T1FUB8 T1FUB8 20212414 PTHR14494:SF0 ALADIN/ADRACALIN/AAAS ALADIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;nuclear division#GO:0000280;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG89553|UniProtKB=T1G7E1 T1G7E1 20216988 PTHR24006:SF952 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG84791|UniProtKB=T1G5N7 T1G5N7 20216384 PTHR11929:SF194 ALPHA- 1,3 -FUCOSYLTRANSFERASE GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 3 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG185141|UniProtKB=T1FMG1 T1FMG1 20210010 PTHR22734:SF3 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 RIBOSOME PRODUCTION FACTOR 1 nucleic acid binding#GO:0003676;binding#GO:0005488;rRNA binding#GO:0019843;RNA binding#GO:0003723 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG71418|UniProtKB=T1G0L3 T1G0L3 20214611 PTHR24347:SF393 SERINE/THREONINE-PROTEIN KINASE SPAGHETTI-SQUASH ACTIVATOR, ISOFORM C protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877 HELRO|EnsemblGenome=HelroG153277|UniProtKB=T1EL24 T1EL24 20197274 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185823|UniProtKB=T1FNC1 T1FNC1 20210318 PTHR45684:SF2 RE74312P SMALL MONOMERIC GTPASE hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;coated membrane#GO:0048475;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HELRO|EnsemblGenome=HelroG164204|UniProtKB=T1EV34 T1EV34 20200434 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193660|UniProtKB=T1FV87 T1FV87 20212733 PTHR32385:SF15 MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;carbohydrate derivative biosynthetic process#GO:1901137;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;glycosphingolipid biosynthetic process#GO:0006688;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407 transferase#PC00220;glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186472|UniProtKB=T1FNZ9 T1FNZ9 20210546 PTHR18860:SF184 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA scaffold/adaptor protein#PC00226 PI3 kinase pathway#P00048>14-3-3#P01206;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624;Parkinson disease#P00049>14-3-3#P01238 HELRO|EnsemblGenome=HelroG157714|UniProtKB=T1EME6 T1EME6 20197746 PTHR11153:SF8 SIDEROFLEXIN SIDEROFLEXIN-1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;intracellular transport#GO:0046907;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;amino acid transport#GO:0006865;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039;cellular localization#GO:0051641;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG183720|UniProtKB=T1FK38 T1FK38 20209187 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG129825|UniProtKB=T1EHS5 T1EHS5 20196125 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN 84-LIKE sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG181061|UniProtKB=T1FGK5 T1FGK5 20207954 PTHR24068:SF126 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 S ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG98567|UniProtKB=T1G9N7 T1G9N7 20217783 PTHR10829:SF25 CORTACTIN AND DREBRIN COACTOSIN-LIKE PROTEIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064 cytoskeleton#GO:0005856;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell periphery#GO:0071944;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG161995|UniProtKB=T1ES48 T1ES48 20199398 PTHR43696:SF9 COILED-COIL DOMAIN-CONTAINING PROTEIN 157 COILED-COIL DOMAIN-CONTAINING PROTEIN 157 HELRO|EnsemblGenome=HelroG189253|UniProtKB=T1FQV5 T1FQV5 20211202 PTHR23281:SF39 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 2 actin binding#GO:0003779;signaling receptor binding#GO:0005102;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;cytoskeletal protein binding#GO:0008092;integrin binding#GO:0005178 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of cell population proliferation#GO:0042127;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of cellular component biogenesis#GO:0044087;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of biological process#GO:0048518;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;filopodium#GO:0030175;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;apical part of cell#GO:0045177;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG90241|UniProtKB=T1G7N0 T1G7N0 20217077 PTHR18945:SF856 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267 chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG127374|UniProtKB=T1EHE3 T1EHE3 20195993 PTHR24333:SF20 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX DOMAIN-CONTAINING PROTEIN helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG184828|UniProtKB=T1FM22 T1FM22 20209871 PTHR10814:SF21 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSCRIPTION FACTOR UNC-37 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HELRO|EnsemblGenome=HelroG175929|UniProtKB=T1F9X0 T1F9X0 20205619 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172808|UniProtKB=T1F5Y6 T1F5Y6 20204236 PTHR10484:SF0 HISTONE H4 HISTONE H4 TYPE VIII structural molecule activity#GO:0005198 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG130122|UniProtKB=T1EHT2 T1EHT2 20196132 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192597|UniProtKB=T1FU42 T1FU42 20212338 PTHR13190:SF1 AUTOPHAGY-RELATED 2, ISOFORM A AUTOPHAGY-RELATED PROTEIN 2 phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-3-phosphate binding#GO:0032266;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495;lipid binding#GO:0008289 polysaccharide catabolic process#GO:0000272;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;glucan catabolic process#GO:0009251;polysaccharide metabolic process#GO:0005976;process utilizing autophagic mechanism#GO:0061919;carbohydrate catabolic process#GO:0016052;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;piecemeal microautophagy of the nucleus#GO:0034727;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;vacuole organization#GO:0007033;reticulophagy#GO:0061709;glycogen catabolic process#GO:0005980;macroautophagy#GO:0016236;generation of precursor metabolites and energy#GO:0006091;autophagy of mitochondrion#GO:0000422;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;pexophagy#GO:0000425 phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG76743|UniProtKB=T1G2N7 T1G2N7 20215335 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG76239|UniProtKB=T1G2H2 T1G2H2 20215270 PTHR11157:SF69 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;oxoacid metabolic process#GO:0043436;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG63269|UniProtKB=T1FXD2 T1FXD2 20213480 PTHR10778:SF13 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1 carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG168146|UniProtKB=T1F080 T1F080 20202230 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG78348|UniProtKB=T1G3A8 T1G3A8 20215556 PTHR45080:SF41 CONTACTIN 5 PALLADIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular component organization#GO:0016043;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 axon#GO:0030424;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;cell body#GO:0044297;neuron projection#GO:0043005 HELRO|EnsemblGenome=HelroG63973|UniProtKB=T1FXN1 T1FXN1 20213579 PTHR16821:SF2 FRATAXIN FRATAXIN, MITOCHONDRIAL cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;iron-sulfur cluster assembly#GO:0016226 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG117028|UniProtKB=T1EGJ4 T1EGJ4 20195696 PTHR10196:SF57 SUGAR KINASE XYLULOSE KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular process#GO:0009987;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 carbohydrate kinase#PC00065;kinase#PC00137 Ascorbate degradation#P02729>L-xylulose kinase#P02849 HELRO|EnsemblGenome=HelroG78010|UniProtKB=T1G367 T1G367 20215515 PTHR45630:SF23 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;polyamine transmembrane transporter activity#GO:0015203 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;transmembrane transport#GO:0055085;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;nitrogen compound transport#GO:0071705;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG120724|UniProtKB=T1EGQ4 T1EGQ4 20195754 PTHR43918:SF17 ACETYLCHOLINESTERASE ACETYLCHOLINESTERASE 1 catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 catabolic process#GO:0009056;metabolic process#GO:0008152;cellular process#GO:0009987 extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 esterase#PC00097 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HELRO|EnsemblGenome=HelroG192562|UniProtKB=T1FU30 T1FU30 20212326 PTHR13738:SF43 TROPONIN I TROPONIN I protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 muscle system process#GO:0003012;muscle contraction#GO:0006936;system process#GO:0003008;multicellular organismal process#GO:0032501 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG112879|UniProtKB=T1EFM8 T1EFM8 20195380 PTHR10856:SF0 CORONIN CORONIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG188719|UniProtKB=T1FQA6 T1FQA6 20211003 PTHR23352:SF2 NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1 HELRO|EnsemblGenome=HelroG77354|UniProtKB=T1G2W8 T1G2W8 20215416 PTHR46280:SF3 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG HELRO|EnsemblGenome=HelroG170303|UniProtKB=T1F2W5 T1F2W5 20203164 PTHR46345:SF8 INVERTED FORMIN-2 INVERTED FORMIN-2 HELRO|EnsemblGenome=HelroG127018|UniProtKB=T1EHC2 T1EHC2 20195972 PTHR24333:SF18 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX DOMAIN-CONTAINING PROTEIN homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG186717|UniProtKB=T1FP26 T1FP26 20210573 PTHR11405:SF5 CARBAMOYLTRANSFERASE FAMILY MEMBER MULTIFUNCTIONAL PROTEIN CAD ligase activity, forming carbon-nitrogen bonds#GO:0016879;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;ligase activity#GO:0016874;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741 amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;pyrimidine nucleobase metabolic process#GO:0006206;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;ligase#PC00142 De novo pyrimidine ribonucleotides biosythesis#P02740>Carbamoyl phosphate synthetase#P02925;Arginine biosynthesis#P02728>Carbamoyl phosphate synthase#P02845 HELRO|EnsemblGenome=HelroG184446|UniProtKB=T1FL80 T1FL80 20209579 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG92274|UniProtKB=T1G8D6 T1G8D6 20217333 PTHR28163:SF1 PROTEIN PET117 HOMOLOG, MITOCHONDRIAL PROTEIN PET117 HOMOLOG, MITOCHONDRIAL respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG195069|UniProtKB=T1FWQ2 T1FWQ2 20213247 PTHR11309:SF148 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 1 signaling receptor activity#GO:0038023;Wnt-protein binding#GO:0017147;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;non-canonical Wnt signaling pathway#GO:0035567;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167091|UniProtKB=T1EZ05 T1EZ05 20201805 PTHR13454:SF11 PROTEIN MCM10 HOMOLOG PROTEIN MCM10 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697 nucleobase-containing compound metabolic process#GO:0006139;DNA replication#GO:0006260;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG160130|UniProtKB=T1EPU5 T1EPU5 20198595 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63110|UniProtKB=T1FXB0 T1FXB0 20213458 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;carbohydrate derivative binding#GO:0097367;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;phosphotransferase activity, alcohol group as acceptor#GO:0016773 purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;ADP catabolic process#GO:0046032;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523 intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220;carbohydrate kinase#PC00065;kinase#PC00137 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG190684|UniProtKB=T1FS72 T1FS72 20211669 PTHR12329:SF5 BCL2-ASSOCIATED ATHANOGENE STARVIN, ISOFORM E binding#GO:0005488;protein-folding chaperone binding#GO:0051087;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;molecular function regulator activity#GO:0098772 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;protein stabilization#GO:0050821;regulation of biological quality#GO:0065008 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG179596|UniProtKB=T1FEX3 T1FEX3 20207372 PTHR11753:SF4 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-4 COMPLEX SUBUNIT SIGMA-1 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG116286|UniProtKB=T1EGE0 T1EGE0 20195642 PTHR24392:SF62 ZINC FINGER PROTEIN PROTEIN CHARLATAN-RELATED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193316|UniProtKB=T1FUV6 T1FUV6 20212602 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG172062|UniProtKB=T1F4Z6 T1F4Z6 20203895 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG185353|UniProtKB=T1FMQ1 T1FMQ1 20210100 PTHR45665:SF63 AQUAPORIN-8 AQUAPORIN OR AQUAGLYCEROPORIN RELATED-RELATED channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;water transport#GO:0006833;localization#GO:0051179;establishment of localization#GO:0051234;fluid transport#GO:0042044 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG104441|UniProtKB=T1EDL7 T1EDL7 20194669 PTHR23153:SF38 UBX-RELATED UBX DOMAIN-CONTAINING PROTEIN 6 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG161356|UniProtKB=T1ERD9 T1ERD9 20199139 PTHR10829:SF58 CORTACTIN AND DREBRIN DREBRIN-LIKE PROTEIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832 intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;lamellipodium#GO:0030027;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;glutamatergic synapse#GO:0098978;cell periphery#GO:0071944;cell leading edge#GO:0031252;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin filament#GO:0005884;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;supramolecular fiber#GO:0099512;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG157751|UniProtKB=T1EMF4 T1EMF4 20197754 PTHR22811:SF210 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN P24-RELATED-1, ISOFORM A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 cellular component organization#GO:0016043;Golgi organization#GO:0007030;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 intracellular organelle#GO:0043229;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG67985|UniProtKB=T1FZ90 T1FZ90 20214138 PTHR11596:SF96 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG176744|UniProtKB=T1FAV3 T1FAV3 20205952 PTHR46468:SF1 SENTRIN-SPECIFIC PROTEASE 8 SENTRIN-SPECIFIC PROTEASE 8 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 protease#PC00190 HELRO|EnsemblGenome=HelroG194392|UniProtKB=T1FW04 T1FW04 20213000 PTHR45766:SF6 DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER SNF2 RELATED CHROMATIN REMODELING ANNEALING HELICASE 1 ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 cellular process#GO:0009987;response to stress#GO:0006950;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG183193|UniProtKB=T1FJA0 T1FJA0 20208899 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG140913|UniProtKB=T1EJ20 T1EJ20 20196570 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER FIBROPELLIN-1-LIKE binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG159979|UniProtKB=T1EPM2 T1EPM2 20198522 PTHR12801:SF115 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED FI18136P1-RELATED exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;exoribonuclease#PC00099 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG174209|UniProtKB=T1F7S8 T1F7S8 20204877 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158112|UniProtKB=T1EMJ5 T1EMJ5 20197795 PTHR11879:SF55 ASPARTATE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HELRO|EnsemblGenome=HelroG127610|UniProtKB=T1EHF8 T1EHF8 20196008 PTHR24340:SF41 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN CEH-24-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG170120|UniProtKB=T1F2N9 T1F2N9 20203088 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188591|UniProtKB=T1FQ55 T1FQ55 20210952 PTHR23004:SF11 DOUBLECORTIN DOMAIN CONTAINING 2 PROTEIN RPI-1 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG80148|UniProtKB=T1G3Y2 T1G3Y2 20215780 PTHR11362:SF133 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN LARGE RIBOSOMAL SUBUNIT PROTEIN ML38 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG184339|UniProtKB=T1FL10 T1FL10 20209509 PTHR33958:SF2 PROTEIN C8ORF37 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 418 ciliary base#GO:0097546;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179186|UniProtKB=T1FEB7 T1FEB7 20207166 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77792|UniProtKB=T1G341 T1G341 20215489 PTHR46614:SF1 MORN REPEAT-CONTAINING PROTEIN 4 MORN REPEAT-CONTAINING PROTEIN 4 response to stress#GO:0006950;response to wounding#GO:0009611;response to stimulus#GO:0050896 cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG132401|UniProtKB=T1EHY4 T1EHY4 20196184 PTHR13225:SF3 MISEXPRESSION SUPPRESSOR OF RAS 6 UPF0489 PROTEIN C5ORF22 HELRO|EnsemblGenome=HelroG65323|UniProtKB=T1FY62 T1FY62 20213760 PTHR12169:SF6 ATPASE N2B AFG1-LIKE ATPASE ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG75758|UniProtKB=T1G299 T1G299 20215197 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG164995|UniProtKB=T1EW33 T1EW33 20200783 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64508|UniProtKB=T1FXV7 T1FXV7 20213655 PTHR18934:SF119 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE A binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853 organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG188954|UniProtKB=T1FQI0 T1FQI0 20211077 PTHR11675:SF134 N-ACETYLGALACTOSAMINYLTRANSFERASE N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG174531|UniProtKB=T1F882 T1F882 20205031 PTHR36960:SF1 SI:DKEY-32E6.3 HMG BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184581|UniProtKB=T1FLI8 T1FLI8 20209687 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156389|UniProtKB=T1ELV2 T1ELV2 20197552 PTHR33668:SF3 PROTEIN BRICK1 PROTEIN BRICK1 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;regulation of anatomical structure size#GO:0090066;regulation of actin nucleation#GO:0051125;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;regulation of cell projection assembly#GO:0060491;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG92151|UniProtKB=T1G8C4 T1G8C4 20217321 PTHR31690:SF4 FUCOSE MUTAROTASE FUCOSE MUTAROTASE binding#GO:0005488;small molecule binding#GO:0036094;monosaccharide binding#GO:0048029;isomerase activity#GO:0016853;carbohydrate binding#GO:0030246;racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;hexose metabolic process#GO:0019318;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG111479|UniProtKB=T1EFB8 T1EFB8 20195270 PTHR24292:SF105 CYTOCHROME P450 CYTOCHROME P450 6A16, ISOFORM B-RELATED oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG88259|UniProtKB=T1G709 T1G709 20216856 PTHR23235:SF197 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG185021|UniProtKB=T1FMA6 T1FMA6 20209955 PTHR45962:SF7 N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1 N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1.1-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG180975|UniProtKB=T1FGH2 T1FGH2 20207921 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169404|UniProtKB=T1F1W5 T1F1W5 20202815 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG164004|UniProtKB=T1EUR2 T1EUR2 20200312 PTHR32546:SF26 G-PROTEIN COUPLED RECEPTOR 158-RELATED SMOG, ISOFORM D G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188329|UniProtKB=T1FPW1 T1FPW1 20210858 PTHR11636:SF76 POU DOMAIN PROTEIN NUBBIN transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG180923|UniProtKB=T1FGF3 T1FGF3 20207902 PTHR13174:SF3 D-GLUCURONYL C5-EPIMERASE D-GLUCURONYL C5-EPIMERASE racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166 isomerase#PC00135 HELRO|EnsemblGenome=HelroG166512|UniProtKB=T1EY71 T1EY71 20201521 PTHR10075:SF110 BASIGIN RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG185207|UniProtKB=T1FMI4 T1FMI4 20210033 PTHR45769:SF3 ADENOSINE KINASE ADENOSINE KINASE nucleoside kinase activity#GO:0019206;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824 purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;purine nucleobase metabolic process#GO:0006144;metabolic process#GO:0008152;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG194371|UniProtKB=T1FVZ8 T1FVZ8 20212994 PTHR10648:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG191378|UniProtKB=T1FSX8 T1FSX8 20211925 PTHR11046:SF31 OLIGORIBONUCLEASE, MITOCHONDRIAL THAP9-LIKE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN RNA metabolism protein#PC00031;endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG108466|UniProtKB=T1EEJ3 T1EEJ3 20194995 PTHR11504:SF17 CYTOCHROME C OXIDASE POLYPEPTIDE VIA CYTOCHROME C OXIDASE SUBUNIT molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123 catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;transporter complex#GO:1990351;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidase#PC00175 HELRO|EnsemblGenome=HelroG111011|UniProtKB=T1EF70 T1EF70 20195222 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG170675|UniProtKB=T1F3B2 T1F3B2 20203311 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG125444|UniProtKB=T1EH60 T1EH60 20195910 PTHR11839:SF15 UDP/ADP-SUGAR PYROPHOSPHATASE URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 metabolite interconversion enzyme#PC00262;pyrophosphatase#PC00196 HELRO|EnsemblGenome=HelroG65543|UniProtKB=T1FY92 T1FY92 20213790 PTHR10257:SF5 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WIDERBORST, ISOFORM H enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888 sister chromatid cohesion#GO:0007062;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular component organization#GO:0016043;cell cycle#GO:0007049;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG192414|UniProtKB=T1FTX8 T1FTX8 20212275 PTHR23167:SF96 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED ALPHA ACTININ 3-RELATED cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161093|UniProtKB=T1ER35 T1ER35 20199035 PTHR46512:SF10 PEPTIDYLPROLYL ISOMERASE FK506-BINDING PROTEIN-LIKE chaperone#PC00072 HELRO|EnsemblGenome=HelroG185649|UniProtKB=T1FN33 T1FN33 20210232 PTHR13299:SF0 PEROXISOMAL MEMBRANE PROTEIN PEX16 PEROXISOMAL MEMBRANE PROTEIN PEX16 cellular component organization or biogenesis#GO:0071840;peroxisome organization#GO:0007031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579 HELRO|EnsemblGenome=HelroG160204|UniProtKB=T1EPY9 T1EPY9 20198639 PTHR21219:SF3 FI19613P1 FI19613P1 HELRO|EnsemblGenome=HelroG189305|UniProtKB=T1FQX9 T1FQX9 20211226 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG182585|UniProtKB=T1FIE8 T1FIE8 20208597 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162833|UniProtKB=T1ET86 T1ET86 20199786 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG180223|UniProtKB=T1FFL2 T1FFL2 20207611 PTHR18895:SF74 HEMK METHYLTRANSFERASE MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 translation#GO:0006412;translational termination#GO:0006415;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex disassembly#GO:0032984;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG145534|UniProtKB=T1EJK8 T1EJK8 20196758 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193472|UniProtKB=T1FV13 T1FV13 20212659 PTHR13455:SF7 TRANSCRIPTIONAL REPRESSOR P66-RELATED SIMJANG, ISOFORM E DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG182090|UniProtKB=T1FHQ3 T1FHQ3 20208352 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168416|UniProtKB=T1F0K3 T1F0K3 20202353 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE transcription coactivator activity#GO:0003713;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transcription regulator activity#GO:0140110;acetyltransferase activity#GO:0016407;binding#GO:0005488;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;chromatin DNA binding#GO:0031490;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;histone acetyltransferase activity#GO:0004402;DNA binding#GO:0003677;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;DPP-SCW signaling pathway#P06212>NEJ#P06260;p53 pathway#P00059>CBP#P04623;Huntington disease#P00029>CBP#P00777;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;DPP signaling pathway#P06213>NEJ#P06284;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295 HELRO|EnsemblGenome=HelroG155336|UniProtKB=T1ELH9 T1ELH9 20197429 PTHR19305:SF14 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;protein binding#GO:0005515;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;binding#GO:0005488 transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;membrane fusion#GO:0061025;synaptic vesicle membrane organization#GO:0048499;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;synaptic vesicle fusion to presynaptic active zone membrane#GO:0031629;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;vesicle fusion#GO:0006906;anterograde trans-synaptic signaling#GO:0098916;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;vesicle fusion to plasma membrane#GO:0099500;exocytosis#GO:0006887;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;secretion by cell#GO:0032940;cellular localization#GO:0051641;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;export from cell#GO:0140352;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944 SNARE protein#PC00034;membrane traffic protein#PC00150 Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Synaptic vesicle trafficking#P05734>SNAP-25#P05778;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049 HELRO|EnsemblGenome=HelroG66203|UniProtKB=T1FYI5 T1FYI5 20213883 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158241|UniProtKB=T1EML0 T1EML0 20197810 PTHR30615:SF8 UNCHARACTERIZED PROTEIN YJBQ-RELATED UPF0047 PROTEIN C4A8.02C HELRO|EnsemblGenome=HelroG172661|UniProtKB=T1F5R2 T1F5R2 20204161 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183587|UniProtKB=T1FJV9 T1FJV9 20209108 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG184609|UniProtKB=T1FLK9 T1FLK9 20209708 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG75629|UniProtKB=T1G278 T1G278 20215176 PTHR24416:SF640 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN VER-1-RELATED transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163539|UniProtKB=T1EU62 T1EU62 20200112 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185082|UniProtKB=T1FMD5 T1FMD5 20209984 PTHR11669:SF20 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 4 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 replication fork#GO:0005657;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG67887|UniProtKB=T1FZ70 T1FZ70 20214118 PTHR15614:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intraciliary transport particle B#GO:0030992;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG184854|UniProtKB=T1FM32 T1FM32 20209881 PTHR19862:SF14 WD REPEAT-CONTAINING PROTEIN 48 WD REPEAT-CONTAINING PROTEIN 48 protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG103239|UniProtKB=T1EDF1 T1EDF1 20194603 PTHR12696:SF5 TIP120 CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular component organization#GO:0016043;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190339|UniProtKB=T1FRX1 T1FRX1 20211568 PTHR13322:SF2 C1ORF73 PROTEIN INTEGRATOR COMPLEX SUBUNIT 7 snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound catabolic process#GO:0034655;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;snRNA 3'-end processing#GO:0034472;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 integrator complex#GO:0032039;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG182130|UniProtKB=T1FHT3 T1FHT3 20208382 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG195025|UniProtKB=T1FWN8 T1FWN8 20213233 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG77374|UniProtKB=T1G2X0 T1G2X0 20215418 PTHR18916:SF82 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;cytoplasmic microtubule organization#GO:0031122;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 nucleus#GO:0005634;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371;microtubule end#GO:1990752;cell cortex#GO:0005938;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874 chaperone#PC00072 HELRO|EnsemblGenome=HelroG173602|UniProtKB=T1F708 T1F708 20204607 PTHR20961:SF167 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG188385|UniProtKB=T1FPX9 T1FPX9 20210876 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG98141|UniProtKB=T1G9L0 T1G9L0 20217756 PTHR24356:SF450 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE TRICORNERED catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;establishment or maintenance of cell polarity#GO:0007163;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG177085|UniProtKB=T1FB80 T1FB80 20206079 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80725|UniProtKB=T1G445 T1G445 20215843 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell fate specification#GO:0001708;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG167642|UniProtKB=T1EZL7 T1EZL7 20202017 PTHR14167:SF92 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81318|UniProtKB=T1G4C9 T1G4C9 20215927 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG79486|UniProtKB=T1G3P4 T1G3P4 20215692 PTHR10030:SF37 ALPHA-L-FUCOSIDASE TISSUE ALPHA-L-FUCOSIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;glycosyl compound catabolic process#GO:1901658;hexose metabolic process#GO:0019318;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG144970|UniProtKB=T1EJH7 T1EJH7 20196727 PTHR11467:SF189 HISTONE H1 HISTONE 24 chromatin DNA binding#GO:0031490;double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of DNA recombination#GO:0000018 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG180087|UniProtKB=T1FFG2 T1FFG2 20207561 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG156457|UniProtKB=T1ELX0 T1ELX0 20197570 PTHR23359:SF206 NUCLEOTIDE KINASE UMP-CMP KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribonucleotide metabolic process#GO:0009259;nucleoside diphosphate metabolic process#GO:0009132;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;ribonucleoside diphosphate metabolic process#GO:0009185;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896;Salvage pyrimidine ribonucleotides#P02775>Cytidylate kinase#P03153;De novo pyrimidine ribonucleotides biosythesis#P02740>Uridylate kinase#P02924 HELRO|EnsemblGenome=HelroG193467|UniProtKB=T1FV10 T1FV10 20212656 PTHR11618:SF4 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT double-stranded DNA binding#GO:0003690;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG76092|UniProtKB=T1G2E8 T1G2E8 20215246 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT AT04468P-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671 establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;transmembrane transport#GO:0055085;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814 ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG153316|UniProtKB=T1EL34 T1EL34 20197358 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180190|UniProtKB=T1FFK3 T1FFK3 20207602 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG186145|UniProtKB=T1FNQ4 T1FNQ4 20210451 PTHR11774:SF4 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG193635|UniProtKB=T1FV78 T1FV78 20212724 PTHR44390:SF1 CENTROSOMAL PROTEIN OF 41 KDA CENTROSOMAL PROTEIN OF 41 KDA cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG85816|UniProtKB=T1G630 T1G630 20216527 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG166122|UniProtKB=T1EXT4 T1EXT4 20201384 PTHR33590:SF4 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG139423|UniProtKB=T1EIY6 T1EIY6 20196536 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG100226|UniProtKB=T1ECZ0 T1ECZ0 20194442 PTHR12841:SF6 PROTEIN UNC-50 HOMOLOG PROTEIN UNC-50 HOMOLOG membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG73174|UniProtKB=T1G1B1 T1G1B1 20214859 PTHR11093:SF2 RUVB-RELATED REPTIN AND PONTIN RUVB-LIKE 2 ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular component biogenesis#GO:0044085;regulation of gene expression#GO:0010468;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;ribonucleoprotein complex biogenesis#GO:0022613;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;protein-RNA complex assembly#GO:0022618 chromatin#GO:0000785;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;Ino80 complex#GO:0031011;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Swr1 complex#GO:0000812;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG83726|UniProtKB=T1G597 T1G597 20216244 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic cell cycle phase transition#GO:0044772;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;regulation of cell cycle#GO:0051726;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;regulation of meiotic cell cycle#GO:0051445;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;regulation of reproductive process#GO:2000241;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;cell cycle G2/M phase transition#GO:0044839;positive regulation of biological process#GO:0048518 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185255|UniProtKB=T1FMK3 T1FMK3 20210052 PTHR23281:SF18 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 biological regulation#GO:0065007;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of anatomical structure morphogenesis#GO:0022603;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008 actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;microvillus#GO:0005902;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;filopodium#GO:0030175;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoskeleton#GO:0005856;apical part of cell#GO:0045177;cell junction#GO:0030054;membraneless organelle#GO:0043228;adherens junction#GO:0005912 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG190662|UniProtKB=T1FS68 T1FS68 20211665 PTHR24215:SF39 RHO-GTPASE-ACTIVATING PROTEIN LRG1 MUSCLE LIM PROTEIN MLP84B cytoskeletal protein binding#GO:0008092;binding#GO:0005488;structural molecule activity#GO:0005198;protein binding#GO:0005515 cellular anatomical entity morphogenesis#GO:0032989;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;developmental process#GO:0032502;cellular developmental process#GO:0048869;tissue development#GO:0009888;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;anatomical structure development#GO:0048856;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061 sarcomere#GO:0030017;membraneless organelle#GO:0043228;I band#GO:0031674;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;contractile muscle fiber#GO:0043292;nucleus#GO:0005634;Z disc#GO:0030018;myofibril#GO:0030016;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG179072|UniProtKB=T1FE53 T1FE53 20207102 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102116|UniProtKB=T1ED81 T1ED81 20194533 PTHR45727:SF11 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 sterol binding#GO:0032934;binding#GO:0005488;small molecule binding#GO:0036094;lipid binding#GO:0008289;cholesterol binding#GO:0015485;steroid binding#GO:0005496;alcohol binding#GO:0043178 lipid homeostasis#GO:0055088;macromolecule localization#GO:0033036;homeostatic process#GO:0042592;multicellular organismal process#GO:0032501;lipid transport#GO:0006869;digestion#GO:0007586;chemical homeostasis#GO:0048878;transport#GO:0006810;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;system process#GO:0003008;establishment of localization#GO:0051234;sterol transport#GO:0015918;cholesterol homeostasis#GO:0042632;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG113251|UniProtKB=T1EFR0 T1EFR0 20195412 PTHR12039:SF0 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753 transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG156859|UniProtKB=T1EM20 T1EM20 20197620 PTHR22957:SF26 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN LD44506P enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG89490|UniProtKB=T1G7D4 T1G7D4 20216981 PTHR23147:SF189 SERINE/ARGININE RICH SPLICING FACTOR SERINE AND ARGININE-RICH-SPLICING FACTOR 3A-RELATED nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG110149|UniProtKB=T1EEZ9 T1EEZ9 20195151 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG169942|UniProtKB=T1F2G5 T1F2G5 20203015 PTHR13720:SF18 WD-40 REPEAT PROTEIN FI23230P1 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG119837|UniProtKB=T1EGN7 T1EGN7 20195737 PTHR10217:SF642 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249 cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;regulation of membrane potential#GO:0042391 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG155709|UniProtKB=T1ELL3 T1ELL3 20197463 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN 7, ISOFORM A phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289 cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;transport#GO:0006810;vesicle organization#GO:0016050;regulation of localization#GO:0032879;regulation of transport#GO:0051049;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;localization#GO:0051179;regulation of secretion#GO:0051046 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG165380|UniProtKB=T1EWP1 T1EWP1 20200991 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157807|UniProtKB=T1EMG1 T1EMG1 20197761 PTHR43725:SF58 UDP-GLUCOSE 4-EPIMERASE UDP-GLUCOSE 4-EPIMERASE racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853 carbohydrate catabolic process#GO:0016052;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;hexose metabolic process#GO:0019318;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 epimerase/racemase#PC00096 Fructose galactose metabolism#P02744>UDP Glucose 4 epimerase#P02965 HELRO|EnsemblGenome=HelroG190021|UniProtKB=T1FRL6 T1FRL6 20211463 PTHR16291:SF0 NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3 NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG175473|UniProtKB=T1F9A5 T1F9A5 20205404 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG161390|UniProtKB=T1ERF3 T1ERF3 20199153 PTHR31809:SF0 BUD13 HOMOLOG BUD13 HOMOLOG nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG113797|UniProtKB=T1EFW7 T1EFW7 20195469 PTHR32170:SF3 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;peptidase activator activity#GO:0016504;peptidase regulator activity#GO:0061134 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG99188|UniProtKB=T1G9R3 T1G9R3 20217809 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HELRO|EnsemblGenome=HelroG192280|UniProtKB=T1FTS6 T1FTS6 20212223 PTHR14030:SF29 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 regulation of mitotic nuclear division#GO:0007088;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;regulation of mitotic sister chromatid separation#GO:0010965;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;biological regulation#GO:0065007;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;sister chromatid cohesion#GO:0007062;negative regulation of chromosome organization#GO:2001251;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;meiotic sister chromatid cohesion#GO:0051177;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;regulation of chromosome segregation#GO:0051983;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;signal transduction#GO:0007165;mitotic spindle assembly checkpoint signaling#GO:0007094;cellular process#GO:0009987;organelle organization#GO:0006996;negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic sister chromatid separation#GO:2000816;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;chromosome#GO:0005694;membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;nucleus#GO:0005634;condensed chromosome, centromeric region#GO:0000779 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190772|UniProtKB=T1FSA2 T1FSA2 20211699 PTHR24253:SF103 TRANSMEMBRANE PROTEASE SERINE TRYPSIN serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG185730|UniProtKB=T1FN76 T1FN76 20210274 PTHR19282:SF252 TETRASPANIN TETRASPANIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189860|UniProtKB=T1FRF4 T1FRF4 20211401 PTHR13832:SF827 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1L phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG69621|UniProtKB=T1FZX3 T1FZX3 20214371 PTHR13720:SF13 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251 cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG193150|UniProtKB=T1FUN8 T1FUN8 20212534 PTHR10098:SF106 RAPSYN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 7B scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156594|UniProtKB=T1ELY8 T1ELY8 20197588 PTHR11359:SF0 AMP DEAMINASE AMP DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;IMP biosynthetic process#GO:0006188;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293 deaminase#PC00088 Purine metabolism#P02769>5'-AMP Deaminase#P03117 HELRO|EnsemblGenome=HelroG171697|UniProtKB=T1F4K4 T1F4K4 20203753 PTHR46205:SF3 LOQUACIOUS, ISOFORM B PROTEIN LOQUACIOUS RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725 cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;siRNA processing#GO:0030422;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ribonucleoprotein complex#GO:1990904;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG194720|UniProtKB=T1FWC4 T1FWC4 20213119 PTHR31638:SF3 DAZ-ASSOCIATED PROTEIN 2 DAZ-ASSOCIATED PROTEIN 2 HELRO|EnsemblGenome=HelroG192861|UniProtKB=T1FUD4 T1FUD4 20212430 PTHR27001:SF118 OS01G0253100 PROTEIN INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 ISOFORM X1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG159569|UniProtKB=T1EP64 T1EP64 20198364 PTHR12791:SF64 GOLGI SNARE BET1-RELATED BET1 HOMOLOG protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 membrane protein complex#GO:0098796;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG183179|UniProtKB=T1FJ95 T1FJ95 20208894 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG79989|UniProtKB=T1G3W0 T1G3W0 20215758 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG191313|UniProtKB=T1FSV6 T1FSV6 20211903 PTHR46165:SF8 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 DOWN AND OUT, ISOFORM A-RELATED enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG101612|UniProtKB=T1ED58 T1ED58 20194510 PTHR11999:SF70 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE MIP05841P lyase#PC00144;decarboxylase#PC00089 Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066;5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961 HELRO|EnsemblGenome=HelroG158207|UniProtKB=T1EMK6 T1EMK6 20197806 PTHR43194:SF2 HYDROLASE ALPHA/BETA FOLD FAMILY PEROXISOMAL MEMBRANE PROTEIN LPX1 hydrolase activity#GO:0016787;lipase activity#GO:0016298;catalytic activity#GO:0003824;triacylglycerol lipase activity#GO:0004806;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788 primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;glycerolipid catabolic process#GO:0046503;acylglycerol metabolic process#GO:0006639;triglyceride catabolic process#GO:0019433;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG110803|UniProtKB=T1EF53 T1EF53 20195205 PTHR23049:SF71 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488 actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG177448|UniProtKB=T1FBQ3 T1FBQ3 20206252 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167127|UniProtKB=T1EZ20 T1EZ20 20201820 PTHR43721:SF2 ELONGATION FACTOR TU-RELATED ELONGATION FACTOR TU, MITOCHONDRIAL translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG194221|UniProtKB=T1FVT9 T1FVT9 20212935 PTHR34930:SF2 GEO05313P1 MICROTUBULE-ASSOCIATED PROTEIN JUPITER microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG146610|UniProtKB=T1EJT4 T1EJT4 20196834 PTHR31305:SF3 SNARE-ASSOCIATED PROTEIN SNAPIN SNARE-ASSOCIATED PROTEIN SNAPIN protein binding#GO:0005515;SNARE binding#GO:0000149;binding#GO:0005488 chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;anterograde trans-synaptic signaling#GO:0098916;homeostatic process#GO:0042592;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;regulation of pH#GO:0006885;signal release#GO:0023061;regulation of intracellular pH#GO:0051453;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;vesicle localization#GO:0051648;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;intracellular transport#GO:0046907;synaptic vesicle cycle#GO:0099504;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;vacuolar transport#GO:0007034;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;signaling#GO:0023052;lysosomal transport#GO:0007041;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;monoatomic ion homeostasis#GO:0050801;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836;regulated exocytosis#GO:0045055;chemical homeostasis#GO:0048878;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;endosomal transport#GO:0016197 presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transport vesicle#GO:0030133;intracellular protein-containing complex#GO:0140535;cell junction#GO:0030054;synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;BLOC-1 complex#GO:0031083;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG169543|UniProtKB=T1F227 T1F227 20202877 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG90406|UniProtKB=T1G7Q9 T1G7Q9 20217106 PTHR23333:SF20 UBX DOMAIN CONTAINING PROTEIN GH01724P ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 organelle localization#GO:0051640;microtubule cytoskeleton organization#GO:0000226;protein metabolic process#GO:0019538;localization#GO:0051179;establishment of cell polarity#GO:0030010;modification-dependent protein catabolic process#GO:0019941;microtubule cytoskeleton organization involved in mitosis#GO:1902850;primary metabolic process#GO:0044238;cell cycle#GO:0007049;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of spindle localization#GO:0051293;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;spindle localization#GO:0051653;cell cycle process#GO:0022402;cellular component organization#GO:0016043;establishment of organelle localization#GO:0051656;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;proteasomal protein catabolic process#GO:0010498;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG62957|UniProtKB=T1FX84 T1FX84 20213432 PTHR24416:SF621 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE KINASE RECEPTOR CAD96CA transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189281|UniProtKB=T1FQX0 T1FQX0 20211217 PTHR24034:SF148 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE58433P extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG80599|UniProtKB=T1G426 T1G426 20215824 PTHR24543:SF339 MULTICOPPER OXIDASE-RELATED LACTADHERIN-LIKE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG69268|UniProtKB=T1FZS4 T1FZS4 20214322 PTHR10694:SF148 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 protein demethylase activity#GO:0140457;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG181683|UniProtKB=T1FH84 T1FH84 20208183 PTHR11534:SF9 MYOGENIC FACTOR MYOGENIC-DETERMINATION PROTEIN DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG172649|UniProtKB=T1F5Q2 T1F5Q2 20204151 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88371|UniProtKB=T1G718 T1G718 20216865 PTHR10801:SF21 24-DEHYDROCHOLESTEROL REDUCTASE DELTA(24)-STEROL REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126 cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG184851|UniProtKB=T1FM30 T1FM30 20209879 PTHR24082:SF506 NUCLEAR HORMONE RECEPTOR NR LBD DOMAIN-CONTAINING PROTEIN C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG180929|UniProtKB=T1FGF7 T1FGF7 20207906 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG89118|UniProtKB=T1G789 T1G789 20216936 PTHR22906:SF56 PROPERDIN HEMICENTIN-1 HELRO|EnsemblGenome=HelroG62839|UniProtKB=T1FX58 T1FX58 20213406 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM K-RELATED intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG182519|UniProtKB=T1FIB2 T1FIB2 20208561 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166695|UniProtKB=T1EYD6 T1EYD6 20201586 PTHR15863:SF2 MRN COMPLEX-INTERACTING PROTEIN MRN COMPLEX-INTERACTING PROTEIN binding#GO:0005488;chromatin binding#GO:0003682 response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cell cycle process#GO:0022402;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;cellular response to stress#GO:0033554;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;intracellular signal transduction#GO:0035556;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG99451|UniProtKB=T1G9S8 T1G9S8 20217824 PTHR48041:SF78 ABC TRANSPORTER G FAMILY MEMBER 28 ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG181703|UniProtKB=T1FH88 T1FH88 20208187 PTHR20963:SF56 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG78004|UniProtKB=T1G365 T1G365 20215513 PTHR10362:SF86 HISTIDINE AMMONIA-LYASE PHENYLALANINE AMMONIA-LYASE-RELATED catalytic activity#GO:0003824;lyase activity#GO:0016829 lyase#PC00144 HELRO|EnsemblGenome=HelroG78542|UniProtKB=T1G3C8 T1G3C8 20215576 PTHR47633:SF4 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182938|UniProtKB=T1FIY1 T1FIY1 20208780 PTHR11759:SF76 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 SMALL RIBOSOMAL SUBUNIT PROTEIN US11M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG176487|UniProtKB=T1FAK5 T1FAK5 20205854 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN YEATS DOMAIN-CONTAINING PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG186249|UniProtKB=T1FNV2 T1FNV2 20210499 PTHR12966:SF0 NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13 oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG172107|UniProtKB=T1F513 T1F513 20203912 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG64381|UniProtKB=T1FXU0 T1FXU0 20213638 PTHR11849:SF190 ETS ETS-DOMAIN PROTEIN DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG115050|UniProtKB=T1EG60 T1EG60 20195562 PTHR11947:SF3 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG98326|UniProtKB=T1G9M0 T1G9M0 20217766 PTHR13906:SF12 PORCUPINE PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;binding#GO:0005488;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein binding#GO:0005515;Wnt-protein binding#GO:0017147 establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;transport#GO:0006810;metabolic process#GO:0008152;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;protein transport#GO:0015031;secretion by cell#GO:0032940;secretion#GO:0046903;cell communication#GO:0007154;protein secretion#GO:0009306;localization#GO:0051179;signal release#GO:0023061;export from cell#GO:0140352;signaling#GO:0023052;protein localization to extracellular region#GO:0071692;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG112487|UniProtKB=T1EFK4 T1EFK4 20195356 PTHR10183:SF437 CALPAIN CALPAIN-5 cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG184684|UniProtKB=T1FLR6 T1FLR6 20209765 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122624|UniProtKB=T1EGV3 T1EGV3 20195803 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG137851|UniProtKB=T1EIP2 T1EIP2 20196442 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG177084|UniProtKB=T1FB79 T1FB79 20206078 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83548|UniProtKB=T1G571 T1G571 20216219 PTHR47977:SF12 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-44 GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG192725|UniProtKB=T1FU83 T1FU83 20212379 PTHR14326:SF67 TARGETING PROTEIN FOR XKLP2 TARGETING PROTEIN FOR XKLP2 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;spindle assembly#GO:0051225;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;nuclear division#GO:0000280;organelle assembly#GO:0070925;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278 mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG154695|UniProtKB=T1ELF7 T1ELF7 20197407 PTHR46207:SF1 PROTEIN RCC2 PROTEIN RCC2 small GTPase binding#GO:0031267;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 regulation of chromosome segregation#GO:0051983;intracellular protein localization#GO:0008104;localization#GO:0051179;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cell cycle process#GO:0090068;macromolecule localization#GO:0033036;protein localization to kinetochore#GO:0034501;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;positive regulation of cell cycle#GO:0045787;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG64375|UniProtKB=T1FXT9 T1FXT9 20213637 PTHR12253:SF34 RH14732P PHOSPHOLIPASE A2 HELRO|EnsemblGenome=HelroG164452|UniProtKB=T1EVF4 T1EVF4 20200554 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG164696|UniProtKB=T1EVQ6 T1EVQ6 20200656 PTHR11259:SF2 RAS-RELATED GTP BINDING RAG/GTR YEAST GH16429P pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of TOR signaling#GO:0032008;negative regulation of catabolic process#GO:0009895;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular response to nutrient levels#GO:0031669;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894 lysosome#GO:0005764;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG92779|UniProtKB=T1G8K9 T1G8K9 20217406 PTHR22957:SF27 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 13 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG173100|UniProtKB=T1F6C4 T1F6C4 20204373 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG187806|UniProtKB=T1FPE1 T1FPE1 20210688 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG82261|UniProtKB=T1G4P8 T1G4P8 20216046 PTHR45701:SF3 SYNAPTOBREVIN FAMILY MEMBER SYNAPTOBREVIN protein binding#GO:0005515;syntaxin binding#GO:0019905;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 vesicle organization#GO:0016050;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;organelle membrane fusion#GO:0090174;vesicle fusion#GO:0006906;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;cellular component organization#GO:0016043;membrane fusion#GO:0061025;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;SNARE complex#GO:0031201 membrane traffic protein#PC00150 Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986 HELRO|EnsemblGenome=HelroG183300|UniProtKB=T1FJF7 T1FJF7 20208956 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG107039|UniProtKB=T1EE69 T1EE69 20194871 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG71423|UniProtKB=T1G0L4 T1G0L4 20214612 PTHR24388:SF53 ZINC FINGER PROTEIN AT-RICH BINDING PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG111539|UniProtKB=T1EFC2 T1EFC2 20195274 PTHR10617:SF107 ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;electron transfer activity#GO:0009055 metabolic process#GO:0008152;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG107158|UniProtKB=T1EE80 T1EE80 20194882 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 bicarbonate transmembrane transporter activity#GO:0015106;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 chemical homeostasis#GO:0048878;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;homeostatic process#GO:0042592 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG111195|UniProtKB=T1EF94 T1EF94 20195246 PTHR10574:SF365 NETRIN/LAMININ-RELATED NETRIN-A-RELATED neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;dendrite development#GO:0016358;anatomical structure morphogenesis#GO:0009653;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;axon development#GO:0061564;axon guidance#GO:0007411;plasma membrane bounded cell projection organization#GO:0120036;tissue development#GO:0009888;multicellular organismal process#GO:0032501;system development#GO:0048731;anatomical structure development#GO:0048856 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HELRO|EnsemblGenome=HelroG96716|UniProtKB=T1G9D4 T1G9D4 20217681 PTHR22762:SF131 ALPHA-GLUCOSIDASE LYSOSOMAL ALPHA-GLUCOSIDASE-LIKE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;glucosidase activity#GO:0015926;alpha-glucosidase activity#GO:0090599;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 glucosidase#PC00108 HELRO|EnsemblGenome=HelroG185640|UniProtKB=T1FN28 T1FN28 20210227 PTHR12688:SF5 DYNEIN LIGHT INTERMEDIATE CHAIN DYNEIN LIGHT INTERMEDIATE CHAIN binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based movement#GO:0007018 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;organelle#GO:0043226;dynein complex#GO:0030286;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG72082|UniProtKB=T1G0V3 T1G0V3 20214701 PTHR12391:SF0 ARP2/3 COMPLEX 21 KD SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 3 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Integrin signalling pathway#P00034>Arp2/3#P00912;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG185936|UniProtKB=T1FNG6 T1FNG6 20210363 PTHR19868:SF0 RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1 SMALL RIBOSOMAL SUBUNIT PROTEIN RACK1 kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 metabolic process#GO:0008152;translational elongation#GO:0006414;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;gene expression#GO:0010467;negative regulation of translation#GO:0017148;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;rescue of stalled cytosolic ribosome#GO:0072344;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;biological regulation#GO:0065007;translation#GO:0006412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG76512|UniProtKB=T1G2K7 T1G2K7 20215305 PTHR22838:SF28 WD REPEAT PROTEIN 26-RELATED WD REPEAT-CONTAINING PROTEIN 26 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG107038|UniProtKB=T1EE68 T1EE68 20194870 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN carboxypeptidase activity#GO:0004180;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG67815|UniProtKB=T1FZ57 T1FZ57 20214105 PTHR22997:SF0 PIH1 DOMAIN-CONTAINING PROTEIN 1 PIH1 DOMAIN-CONTAINING PROTEIN 1 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG195122|UniProtKB=T1FWS0 T1FWS0 20213265 PTHR11467:SF189 HISTONE H1 HISTONE 24 chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-containing complex binding#GO:0044877;double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;DNA binding#GO:0003677 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG187909|UniProtKB=T1FPG7 T1FPG7 20210714 PTHR11361:SF148 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN MSH6 DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG89500|UniProtKB=T1G7D9 T1G7D9 20216986 PTHR24416:SF640 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN VER-1-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG154313|UniProtKB=T1ELE4 T1ELE4 20197394 PTHR23409:SF18 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 reductase#PC00198;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo purine biosynthesis#P02738>GDP reductase#P02909;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921 HELRO|EnsemblGenome=HelroG102529|UniProtKB=T1EDA0 T1EDA0 20194552 PTHR43721:SF11 ELONGATION FACTOR TU-RELATED SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051 regulation of macromolecule metabolic process#GO:0060255;protein biosynthetic process#GO:0160307;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;translation#GO:0006412;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;translational elongation#GO:0006414;metabolic process#GO:0008152;post-transcriptional regulation of gene expression#GO:0010608 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG191221|UniProtKB=T1FSR4 T1FSR4 20211861 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG172327|UniProtKB=T1F574 T1F574 20203973 PTHR23359:SF70 NUCLEOTIDE KINASE ADENYLATE KINASE ISOENZYME 1 phosphotransferase activity, phosphate group as acceptor#GO:0016776;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG188198|UniProtKB=T1FPR7 T1FPR7 20210814 PTHR43807:SF23 FI04487P FI04487P transaminase activity#GO:0008483;catalytic activity#GO:0003824;transferase activity#GO:0016740 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transferase#PC00220;transaminase#PC00216;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187398|UniProtKB=T1FP96 T1FP96 20210643 PTHR10865:SF29 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN METASTASIS-ASSOCIATED PROTEIN MTA3 protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;histone deacetylase binding#GO:0042826;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 p53 pathway#P00059>MTA2#P04615 HELRO|EnsemblGenome=HelroG189665|UniProtKB=T1FR87 T1FR87 20211334 PTHR48031:SF7 SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL RNA-BINDING PROTEIN 18-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 HELRO|EnsemblGenome=HelroG97810|UniProtKB=T1G9J1 T1G9J1 20217738 PTHR12121:SF100 CARBON CATABOLITE REPRESSOR PROTEIN 4 POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;CCR4-NOT complex#GO:0030014;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG189001|UniProtKB=T1FQJ7 T1FQJ7 20211094 PTHR22746:SF11 RAB6A-GEF COMPLEX PARTNER PROTEIN 1 GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 transport#GO:0006810;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;intracellular transport#GO:0046907;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;axon development#GO:0061564;axon guidance#GO:0007411;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;protein localization to cell junction#GO:1902414;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;plasma membrane bounded cell projection morphogenesis#GO:0120039;intracellular protein transport#GO:0006886;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;endosomal transport#GO:0016197;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein localization to synapse#GO:0035418;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;vesicle-mediated transport#GO:0016192;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;protein transport#GO:0015031;cellular localization#GO:0051641;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cytosolic transport#GO:0016482;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;organelle#GO:0043226;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG183282|UniProtKB=T1FJE7 T1FJE7 20208946 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG63981|UniProtKB=T1FXN2 T1FXN2 20213580 PTHR11909:SF520 CASEIN KINASE-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>Casein kinase I#P01242;Wnt signaling pathway#P00057>Casein Kinase 1#P01460 HELRO|EnsemblGenome=HelroG87192|UniProtKB=T1G6N0 T1G6N0 20216727 PTHR13673:SF0 ESOPHAGEAL CANCER ASSOCIATED PROTEIN VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157327|UniProtKB=T1EM98 T1EM98 20197698 PTHR12838:SF0 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED organelle lumen#GO:0043233;small-subunit processome#GO:0032040;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG92830|UniProtKB=T1G8L7 T1G8L7 20217414 PTHR11434:SF22 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG166151|UniProtKB=T1EXU5 T1EXU5 20201395 PTHR19316:SF18 PROTEIN FOLDING REGULATOR HSP70-BINDING PROTEIN 1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG188137|UniProtKB=T1FPP1 T1FPP1 20210788 PTHR45760:SF2 FI19922P1-RELATED FI19922P1-RELATED intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG159763|UniProtKB=T1EPD7 T1EPD7 20198437 PTHR12264:SF21 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG112468|UniProtKB=T1EFK1 T1EFK1 20195353 PTHR24270:SF68 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LD11117P-RELATED endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG182058|UniProtKB=T1FHP0 T1FHP0 20208339 PTHR19282:SF516 TETRASPANIN LEUKOCYTE ANTIGEN CD37 ISOFORM X1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG107137|UniProtKB=T1EE77 T1EE77 20194879 PTHR11447:SF16 CELLULAR TUMOR ANTIGEN P53 P53, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;regulation of gene expression#GO:0010468;apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;DNA damage response#GO:0006974;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 P53-like transcription factor#PC00253;gene-specific transcriptional regulator#PC00264 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG188689|UniProtKB=T1FQ93 T1FQ93 20210990 PTHR10962:SF1 INTEGRAL TRANSMEMBRANE PROTEIN 2 INTEGRAL MEMBRANE PROTEIN 2 peptide binding#GO:0042277;binding#GO:0005488 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG66182|UniProtKB=T1FYI1 T1FYI1 20213879 PTHR21600:SF94 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD1 intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG165757|UniProtKB=T1EX93 T1EX93 20201193 PTHR45797:SF1 RAD54-LIKE HELICASE ARIP4 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG155611|UniProtKB=T1ELJ6 T1ELJ6 20197446 PTHR22780:SF5 ADAPTIN, ALPHA/GAMMA/EPSILON AP-1 COMPLEX SUBUNIT GAMMA cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;establishment of localization in cell#GO:0051649;Golgi to endosome transport#GO:0006895;cellular process#GO:0009987 membrane#GO:0016020;vesicle membrane#GO:0012506;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;clathrin-coated vesicle#GO:0030136;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;membrane coat#GO:0030117;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vesicle coat#GO:0030120;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle membrane#GO:0030665;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;intracellular vesicle#GO:0097708;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular organelle#GO:0043229;coated membrane#GO:0048475;coated vesicle#GO:0030135 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178752|UniProtKB=T1FDN8 T1FDN8 20206937 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193204|UniProtKB=T1FUR1 T1FUR1 20212557 PTHR13328:SF7 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG155870|UniProtKB=T1ELN5 T1ELN5 20197485 PTHR42752:SF1 IMIDAZOLONEPROPIONASE IMIDAZOLONEPROPIONASE-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG161007|UniProtKB=T1ER01 T1ER01 20199001 PTHR24343:SF166 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 6 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 sexual reproduction#GO:0019953;spermatid development#GO:0007286;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;cell differentiation#GO:0030154;gamete generation#GO:0007276;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular process#GO:0009987;male gamete generation#GO:0048232 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG103432|UniProtKB=T1EDG1 T1EDG1 20194613 PTHR11060:SF0 PROTEIN MEMO1 PROTEIN MEMO1 HELRO|EnsemblGenome=HelroG179839|UniProtKB=T1FF72 T1FF72 20207471 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG123894|UniProtKB=T1EGZ5 T1EGZ5 20195845 PTHR23050:SF536 CALCIUM BINDING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG167561|UniProtKB=T1EZH7 T1EZH7 20201977 PTHR11414:SF21 CYSTATIN FAMILY MEMBER CYSTATIN 14B, TANDEM DUPLICATE 2-RELATED endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185018|UniProtKB=T1FMA3 T1FMA3 20209952 PTHR13493:SF3 ZINC FINGER CCHC DOMAIN-CONTAINING RRNA N(6)-ADENOSINE-METHYLTRANSFERASE ZCCHC4 rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity, acting on a rRNA#GO:0140102;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;RNA methyltransferase activity#GO:0008173;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;rRNA methylation#GO:0031167;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA modification#GO:0000154;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;methylation#GO:0032259;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG172868|UniProtKB=T1F618 T1F618 20204267 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG194849|UniProtKB=T1FWH4 T1FWH4 20213169 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG176861|UniProtKB=T1FAZ8 T1FAZ8 20205997 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to nutrient levels#GO:0031667;response to starvation#GO:0042594;response to stress#GO:0006950;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG189231|UniProtKB=T1FQU3 T1FQU3 20211190 PTHR33768:SF3 MIP11318P MIP11318P HELRO|EnsemblGenome=HelroG193029|UniProtKB=T1FUJ5 T1FUJ5 20212491 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN developmental process#GO:0032502;anatomical structure development#GO:0048856 HELRO|EnsemblGenome=HelroG109631|UniProtKB=T1EEV3 T1EEV3 20195105 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER FIBROPELLIN-1-LIKE protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG68491|UniProtKB=T1FZF5 T1FZF5 20214203 PTHR23354:SF132 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED OXIDATION RESISTANCE PROTEIN 1 response to stimulus#GO:0050896;response to oxidative stress#GO:0006979;response to stress#GO:0006950 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG160118|UniProtKB=T1EPU0 T1EPU0 20198590 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG77001|UniProtKB=T1G2S3 T1G2S3 20215371 PTHR19818:SF178 ZINC FINGER PROTEIN ZIC AND GLI PAIR-RULE PROTEIN ODD-PAIRED DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG194132|UniProtKB=T1FVQ4 T1FVQ4 20212900 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG82302|UniProtKB=T1G4Q4 T1G4Q4 20216052 PTHR19957:SF307 SYNTAXIN SYNTAXIN-1A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;secretion#GO:0046903;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;secretion by cell#GO:0032940;cellular component organization#GO:0016043;export from cell#GO:0140352;vesicle fusion#GO:0006906 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066 HELRO|EnsemblGenome=HelroG85072|UniProtKB=T1G5S4 T1G5S4 20216421 PTHR45695:SF42 LEUCOKININ RECEPTOR-RELATED GALANIN-LIKE G PROTEIN-COUPLED RECEPTOR NPR-9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG112439|UniProtKB=T1EFK0 T1EFK0 20195352 PTHR43462:SF1 ALANYL-TRNA EDITING PROTEIN ALANYL-TRNA EDITING PROTEIN AARSD1 catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;deacylase activity#GO:0160215;catalytic activity, acting on a nucleic acid#GO:0140640 regulation of biological quality#GO:0065008;biological regulation#GO:0065007 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174822|UniProtKB=T1F8I7 T1F8I7 20205136 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG76281|UniProtKB=T1G2H7 T1G2H7 20215275 PTHR23293:SF9 FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE BIFUNCTIONAL FAD DIPHOSPHATASE_FAD SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566 nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;flavin-containing compound metabolic process#GO:0042726;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;transferase#PC00220 Flavin biosynthesis#P02741>FAD synthetase#P02936 HELRO|EnsemblGenome=HelroG194864|UniProtKB=T1FWI0 T1FWI0 20213175 PTHR44196:SF1 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B PEROXISOMAL REDUCTASE ACTIVATING PPAR-GAMMA membrane#GO:0016020;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG168552|UniProtKB=T1F0Q0 T1F0Q0 20202400 PTHR19282:SF417 TETRASPANIN TOBAMOVIRUS MULTIPLICATION PROTEIN 2A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188525|UniProtKB=T1FQ33 T1FQ33 20210930 PTHR45615:SF36 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;actomyosin structure organization#GO:0031032;cytoskeleton organization#GO:0007010 actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG167990|UniProtKB=T1F017 T1F017 20202167 PTHR45694:SF5 GLUTAREDOXIN 2 GLUTAREDOXIN-C4 oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG175937|UniProtKB=T1F9X7 T1F9X7 20205626 PTHR35450:SF2 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN C1Q DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172141|UniProtKB=T1F523 T1F523 20203922 PTHR17616:SF8 YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER YES-ASSOCIATED PROTEIN HOMOLOG 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of macromolecule metabolic process#GO:0010604;hippo signaling#GO:0035329;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG177803|UniProtKB=T1FCA5 T1FCA5 20206454 PTHR44163:SF1 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;rRNA processing#GO:0006364;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 t-UTP complex#GO:0034455;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG77547|UniProtKB=T1G2Z6 T1G2Z6 20215444 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG185669|UniProtKB=T1FN43 T1FN43 20210241 PTHR12561:SF3 LIPOATE-PROTEIN LIGASE LIPOYL AMIDOTRANSFERASE LIPT1, MITOCHONDRIAL acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178828|UniProtKB=T1FDT0 T1FDT0 20206979 PTHR10334:SF603 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG170765|UniProtKB=T1F3E3 T1F3E3 20203342 PTHR10037:SF230 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F metal ion transmembrane transporter activity#GO:0046873;voltage-gated sodium channel activity#GO:0005248;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;metal ion transport#GO:0030001;biological regulation#GO:0065007;membrane depolarization#GO:0051899;calcium ion import#GO:0070509;action potential#GO:0001508 cation channel complex#GO:0034703;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;neuron projection#GO:0043005;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG164912|UniProtKB=T1EVY8 T1EVY8 20200738 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG187620|UniProtKB=T1FPB2 T1FPB2 20210659 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108 transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;action potential#GO:0001508;metal ion transport#GO:0030001 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG187713|UniProtKB=T1FPC2 T1FPC2 20210669 PTHR12918:SF1 CYSTEINE DIOXYGENASE CYSTEINE DIOXYGENASE TYPE 1 ferrous iron binding#GO:0008198;catalytic activity#GO:0003824;iron ion binding#GO:0005506;oxidoreductase activity#GO:0016491;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;cation binding#GO:0043169;metal ion binding#GO:0046872;dioxygenase activity#GO:0051213 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;sulfur compound metabolic process#GO:0006790;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;sulfur compound catabolic process#GO:0044273 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG185617|UniProtKB=T1FN17 T1FN17 20210216 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG98638|UniProtKB=T1G9N9 T1G9N9 20217785 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;sarcoplasmic reticulum#GO:0016529;endomembrane system#GO:0012505;sarcoplasmic reticulum membrane#GO:0033017;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG63136|UniProtKB=T1FXB5 T1FXB5 20213463 PTHR45833:SF1 METHIONINE SYNTHASE METHIONINE SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 tetrahydrofolate metabolic process#GO:0046653;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid biosynthetic process#GO:0170038;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 S-adenosylmethionine biosynthesis#P02773>Cobalamin-dependent homocysteine transmethylase#P03142;Formyltetrahydrofolate biosynthesis#P02743>Cobalamin dependent homocysteine transmethylase#P02953;Methionine biosynthesis#P02753>Homocysteine transmethylase#P03024 HELRO|EnsemblGenome=HelroG189841|UniProtKB=T1FRE9 T1FRE9 20211396 PTHR21522:SF68 PROTON CHANNEL OTOP SUBFAMILY NOT NAMED channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;proton channel activity#GO:0015252 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG107948|UniProtKB=T1EEE3 T1EEE3 20194945 PTHR45625:SF4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1 cis-trans isomerase activity#GO:0016859;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 chaperone#PC00072 HELRO|EnsemblGenome=HelroG175392|UniProtKB=T1F984 T1F984 20205383 PTHR34524:SF15 CALCYPHOSIN EF-HAND DOMAIN-CONTAINING PROTEIN calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG158679|UniProtKB=T1EN43 T1EN43 20197993 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG188314|UniProtKB=T1FPV3 T1FPV3 20210850 PTHR10288:SF358 KH DOMAIN CONTAINING RNA BINDING PROTEIN P-ELEMENT SOMATIC INHIBITOR, ISOFORM C mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of mRNA splicing, via spliceosome#GO:0048024;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189191|UniProtKB=T1FQR6 T1FQR6 20211163 PTHR31437:SF1 SREK1IP1 FAMILY MEMBER PROTEIN SREK1IP1 HELRO|EnsemblGenome=HelroG162954|UniProtKB=T1ETF0 T1ETF0 20199850 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181735|UniProtKB=T1FH97 T1FH97 20208196 PTHR31206:SF1 LP10445P LP10445P HELRO|EnsemblGenome=HelroG156650|UniProtKB=T1ELZ3 T1ELZ3 20197593 PTHR11002:SF76 CARBONIC ANHYDRASE CARBONIC ANHYDRASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG163210|UniProtKB=T1ETT0 T1ETT0 20199980 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65481|UniProtKB=T1FY83 T1FY83 20213781 PTHR22603:SF36 CHOLINE/ETHANOALAMINE KINASE CHOLINE KINASE ALPHA transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine biosynthetic process#GO:0006656;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG179258|UniProtKB=T1FEG0 T1FEG0 20207209 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN EXPRESSED PROTEIN methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;transferase activity#GO:0016740 methyltransferase#PC00155;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161716|UniProtKB=T1ERT8 T1ERT8 20199288 PTHR32178:SF6 FAM187 IG-LIKE DOMAIN-CONTAINING PROTEIN immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG72245|UniProtKB=T1G0X5 T1G0X5 20214723 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG189721|UniProtKB=T1FRA6 T1FRA6 20211353 PTHR22692:SF33 MYOSIN VII, XV MYOSIN-VIIA actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG184018|UniProtKB=T1FKF6 T1FKF6 20209305 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG189328|UniProtKB=T1FQY7 T1FQY7 20211234 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G complement component#PC00078;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG66624|UniProtKB=T1FYN3 T1FYN3 20213931 PTHR48012:SF9 STERILE20-LIKE KINASE, ISOFORM B-RELATED SERINE_THREONINE-PROTEIN KINASE 25 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185880|UniProtKB=T1FNE1 T1FNE1 20210338 PTHR12815:SF18 SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;protein insertion into mitochondrial outer membrane#GO:0045040;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104 mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial outer membrane translocase complex#GO:0005742;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741 HELRO|EnsemblGenome=HelroG160670|UniProtKB=T1EQL0 T1EQL0 20198860 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177154|UniProtKB=T1FBA3 T1FBA3 20206102 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 binding#GO:0005488;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG182180|UniProtKB=T1FHV8 T1FHV8 20208407 PTHR13723:SF313 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG169668|UniProtKB=T1F276 T1F276 20202926 PTHR21771:SF1 MITOCHONDRIA-EATING PROTEIN-RELATED MITOCHONDRIA-EATING PROTEIN HELRO|EnsemblGenome=HelroG173299|UniProtKB=T1F6N4 T1F6N4 20204483 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN EXPRESSED PROTEIN methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;O-methyltransferase activity#GO:0008171;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG153391|UniProtKB=T1EL65 T1EL65 20197315 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG113572|UniProtKB=T1EFT9 T1EFT9 20195441 PTHR19384:SF17 NITRIC OXIDE SYNTHASE-RELATED NADPH--CYTOCHROME P450 REDUCTASE oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;oxidoreductase activity, acting on NAD(P)H#GO:0016651;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Vitamin D metabolism and pathway#P04396>P450 reductase#P04605 HELRO|EnsemblGenome=HelroG186992|UniProtKB=T1FP50 T1FP50 20210597 PTHR10665:SF0 RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS SUPPRESSOR OF HAIRLESS PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Angiogenesis#P00005>CSL#P00233;Alzheimer disease-presenilin pathway#P00004>CSL#P00158;Notch signaling pathway#P00045>Su(H)#P01101 HELRO|EnsemblGenome=HelroG161080|UniProtKB=T1ER29 T1ER29 20199029 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG89615|UniProtKB=T1G7E9 T1G7E9 20216996 PTHR21236:SF1 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF6 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791 structural protein#PC00211 HELRO|EnsemblGenome=HelroG70666|UniProtKB=T1G0A2 T1G0A2 20214500 PTHR19290:SF134 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIC DIFFERENTIATION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG64399|UniProtKB=T1FXU3 T1FXU3 20213641 PTHR24345:SF93 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cellular process#GO:0009987;cell cycle process#GO:0022402;organelle organization#GO:0006996;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule cytoskeleton organization#GO:0000226 membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;spindle pole#GO:0000922;kinetochore#GO:0000776 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG182628|UniProtKB=T1FII0 T1FII0 20208629 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190982|UniProtKB=T1FSH0 T1FSH0 20211767 PTHR24044:SF512 NOTCH LIGAND FAMILY MEMBER PROTEIN LIN-12 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Next#P01103;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120 HELRO|EnsemblGenome=HelroG70532|UniProtKB=T1G077 T1G077 20214475 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG158187|UniProtKB=T1EMK1 T1EMK1 20197801 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;DNA-templated transcription elongation#GO:0006354;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77754|UniProtKB=T1G334 T1G334 20215482 PTHR24343:SF299 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG192807|UniProtKB=T1FUB5 T1FUB5 20212411 PTHR14952:SF21 ROPPORIN-1-LIKE PROTEIN IQ DOMAIN-CONTAINING PROTEIN E cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;spermatid differentiation#GO:0048515;cilium-dependent cell motility#GO:0060285;sperm motility#GO:0097722;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;gamete generation#GO:0007276;cell differentiation#GO:0030154;microtubule-based process#GO:0007017;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;sperm capacitation#GO:0048240;spermatid development#GO:0007286;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;localization#GO:0051179;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;protein localization to cilium#GO:0061512;microtubule-based movement#GO:0007018;cell motility#GO:0048870;protein localization to organelle#GO:0033365;spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;intracellular protein localization#GO:0008104;cellular developmental process#GO:0048869;cell maturation#GO:0048469;macromolecule localization#GO:0033036;male gamete generation#GO:0048232;developmental maturation#GO:0021700 cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG162069|UniProtKB=T1ES81 T1ES81 20199431 PTHR21505:SF12 MADF DOMAIN-CONTAINING PROTEIN-RELATED MADF DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG182099|UniProtKB=T1FHR0 T1FHR0 20208359 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG145252|UniProtKB=T1EJJ7 T1EJJ7 20196747 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG172156|UniProtKB=T1F529 T1F529 20203928 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191893|UniProtKB=T1FTE4 T1FTE4 20212091 PTHR21091:SF169 METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED UROPORPHYRINOGEN DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824 metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;porphyrin-containing compound biosynthetic process#GO:0006779;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 methyltransferase#PC00155 Heme biosynthesis#P02746>Uroporphyrinogen decarboxylase#P02975 HELRO|EnsemblGenome=HelroG154062|UniProtKB=T1ELD6 T1ELD6 20197386 PTHR24070:SF462 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY SMALL MONOMERIC GTPASE hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cell communication#GO:0007154;regulation of cell motility#GO:2000145;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cell migration#GO:0030334 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906 HELRO|EnsemblGenome=HelroG70549|UniProtKB=T1G080 T1G080 20214478 PTHR12978:SF0 HISTIDINE TRIAD HIT PROTEIN MEMBER M7GPPPX DIPHOSPHATASE nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of RNA stability#GO:0043487;RNA decapping#GO:0110154;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG168248|UniProtKB=T1F0C7 T1F0C7 20202277 PTHR24248:SF120 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG111895|UniProtKB=T1EFF4 T1EFF4 20195306 PTHR12072:SF4 CWF19, CELL CYCLE CONTROL PROTEIN CWF19-LIKE PROTEIN 1 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG81474|UniProtKB=T1G4E7 T1G4E7 20215945 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG178132|UniProtKB=T1FCT2 T1FCT2 20206631 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG149394|UniProtKB=T1EKC9 T1EKC9 20197029 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG175037|UniProtKB=T1F8R8 T1F8R8 20205217 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG78123|UniProtKB=T1G384 T1G384 20215532 PTHR47958:SF103 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX41-RELATED mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG183522|UniProtKB=T1FJS3 T1FJS3 20209072 PTHR11003:SF359 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG159218|UniProtKB=T1ENR3 T1ENR3 20198213 PTHR12496:SF0 CGI-41 METHYLTRANSFERASE METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG110223|UniProtKB=T1EF06 T1EF06 20195158 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of transport#GO:0051049;regulation of localization#GO:0032879;intracellular protein localization#GO:0008104;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;macromolecule localization#GO:0033036;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of neurotransmitter secretion#GO:0046928;regulation of biological process#GO:0050789 anchoring junction#GO:0070161;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG101759|UniProtKB=T1ED68 T1ED68 20194520 PTHR11932:SF180 CULLIN CULLIN-3 protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056 intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG85729|UniProtKB=T1G624 T1G624 20216521 PTHR24270:SF8 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED VITELLOGENIN RECEPTOR YL cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG102128|UniProtKB=T1ED82 T1ED82 20194534 PTHR15588:SF8 LSM1 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;intracellular anatomical structure#GO:0005622;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG75424|UniProtKB=T1G250 T1G250 20215148 PTHR24355:SF18 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;G protein-coupled receptor binding#GO:0001664;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;binding#GO:0005488;signaling receptor binding#GO:0005102;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cell communication#GO:0010646;signaling#GO:0023052;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin kinase#P00750;Parkinson disease#P00049>GRK#P01234;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>GRK3#P05941 HELRO|EnsemblGenome=HelroG159297|UniProtKB=T1ENU8 T1ENU8 20198248 PTHR11552:SF233 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE FI02019P catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG126488|UniProtKB=T1EH99 T1EH99 20195949 PTHR12146:SF0 40S RIBOSOMAL PROTEIN S10 RIBOSOMAL PROTEIN S10 structural molecule activity#GO:0005198;RNA binding#GO:0003723;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG193762|UniProtKB=T1FVC1 T1FVC1 20212767 PTHR13328:SF6 NEGATIVE ELONGATION FACTOR A NELF-A GEX-3-INTERACTING PROTEIN 13 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG192138|UniProtKB=T1FTM3 T1FTM3 20212170 PTHR21595:SF0 PATRONIN PATRONIN tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of organelle organization#GO:0010639;cellular component organization#GO:0016043;negative regulation of cellular component organization#GO:0051129;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;cytoplasmic microtubule organization#GO:0031122;negative regulation of cellular process#GO:0048523;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein depolymerization#GO:1901879;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of microtubule cytoskeleton organization#GO:0070507 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;microtubule end#GO:1990752;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG100431|UniProtKB=T1ECZ7 T1ECZ7 20194449 PTHR15588:SF9 LSM1 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;U6 snRNP#GO:0005688;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG187346|UniProtKB=T1FP90 T1FP90 20210637 PTHR21017:SF17 NIPSNAP-RELATED PROTEIN NIPSNAP HELRO|EnsemblGenome=HelroG187613|UniProtKB=T1FPB1 T1FPB1 20210658 PTHR12141:SF1 ARFAPTIN-RELATED PRKCA-BINDING PROTEIN molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 regulation of actin nucleation#GO:0051125;regulation of actin filament-based process#GO:0032970;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;positive regulation of endocytosis#GO:0045807;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;synapse organization#GO:0050808;localization within membrane#GO:0051668;localization#GO:0051179;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;postsynapse organization#GO:0099173;regulation of endocytosis#GO:0030100;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of biological process#GO:0048518;dendritic spine organization#GO:0097061;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;establishment of protein localization#GO:0045184;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;receptor clustering#GO:0043113;positive regulation of cellular component organization#GO:0051130;cellular localization#GO:0051641;protein transport#GO:0015031;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;neuron projection organization#GO:0106027;regulation of receptor-mediated endocytosis#GO:0048259;cell projection organization#GO:0030030 trans-Golgi network membrane#GO:0032588;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cell junction#GO:0030054;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;intracellular vesicle#GO:0097708;postsynapse#GO:0098794;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;postsynaptic specialization#GO:0099572;transport vesicle#GO:0030133;neuron to neuron synapse#GO:0098984;endomembrane system#GO:0012505;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;asymmetric synapse#GO:0032279;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;postsynaptic density#GO:0014069 vesicle coat protein#PC00235 Ionotropic glutamate receptor pathway#P00037>PICK#P01012 HELRO|EnsemblGenome=HelroG176769|UniProtKB=T1FAW3 T1FAW3 20205962 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG184813|UniProtKB=T1FM15 T1FM15 20209864 PTHR12098:SF2 E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED PROTEIN PELLINO aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175001|UniProtKB=T1F8Q0 T1F8Q0 20205199 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191574|UniProtKB=T1FT34 T1FT34 20211981 PTHR13948:SF3 RNA-BINDING PROTEIN FI21118P1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG173455|UniProtKB=T1F6U9 T1F6U9 20204548 PTHR12352:SF3 SECRETED MODULAR CALCIUM-BINDING PROTEIN NIDOGEN-2 cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG128902|UniProtKB=T1EHQ8 T1EHQ8 20196108 PTHR11702:SF31 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG166015|UniProtKB=T1EXL4 T1EXL4 20201314 PTHR12449:SF22 DEATH DOMAIN-CONTAINING PROTEIN NUCLEOLAR PROTEIN 4-LIKE ISOFORM X1 HELRO|EnsemblGenome=HelroG63123|UniProtKB=T1FXB3 T1FXB3 20213461 PTHR12756:SF9 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 6 carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;protein binding#GO:0005515;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;binding#GO:0005488;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG81692|UniProtKB=T1G4H7 T1G4H7 20215975 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG173781|UniProtKB=T1F780 T1F780 20204679 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG108615|UniProtKB=T1EEL0 T1EEL0 20195012 PTHR11473:SF46 AROMATIC AMINO ACID HYDROXYLASE PROTEIN HENNA catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;biogenic amine metabolic process#GO:0006576;amine metabolic process#GO:0009308;phenol-containing compound biosynthetic process#GO:0046189;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid biosynthetic process#GO:0170038;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;serotonin biosynthetic process#GO:0042427;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;aromatic amino acid biosynthetic process#GO:0009073;carboxylic acid biosynthetic process#GO:0046394;indole-containing compound metabolic process#GO:0042430;phenol-containing compound metabolic process#GO:0018958;catecholamine metabolic process#GO:0006584;serotonin metabolic process#GO:0042428;oxoacid metabolic process#GO:0043436 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175520|UniProtKB=T1F9C7 T1F9C7 20205426 PTHR10742:SF405 FLAVIN MONOAMINE OXIDASE LD37279P oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidase#PC00175 HELRO|EnsemblGenome=HelroG156381|UniProtKB=T1ELV0 T1ELV0 20197550 PTHR47507:SF6 BARRIER TO AUTOINTEGRATION FACTOR 2 BARRIER-TO-AUTOINTEGRATION FACTOR binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840 chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164021|UniProtKB=T1EUS3 T1EUS3 20200323 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172326|UniProtKB=T1F573 T1F573 20203972 PTHR13391:SF1 MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO PROTEIN MISATO HOMOLOG 1 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG68824|UniProtKB=T1FZK2 T1FZK2 20214250 PTHR23105:SF1 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN EL8 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG169937|UniProtKB=T1F2G4 T1F2G4 20203014 PTHR23167:SF46 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG113133|UniProtKB=T1EFQ5 T1EFQ5 20195407 PTHR45887:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON TRANSLATION INITIATION FACTOR EIF2B SUBUNIT EPSILON translation initiation factor activity#GO:0003743;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;translation initiation factor binding#GO:0031369;nucleoside-triphosphatase regulator activity#GO:0060589;translation factor activity#GO:0180051;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085 guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG189348|UniProtKB=T1FQZ7 T1FQZ7 20211244 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157734|UniProtKB=T1EME9 T1EME9 20197749 PTHR11021:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F SMALL NUCLEAR RIBONUCLEOPROTEIN F RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG192950|UniProtKB=T1FUG2 T1FUG2 20212458 PTHR12121:SF105 CARBON CATABOLITE REPRESSOR PROTEIN 4 PROTEIN ANGEL hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;nuclease activity#GO:0004518;binding#GO:0005488;exonuclease activity#GO:0004527;mRNA binding#GO:0003729;3'-5'-RNA exonuclease activity#GO:0000175;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;mRNA 3'-UTR binding#GO:0003730 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;mitochondrial RNA 3'-end processing#GO:0000965;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;mitochondrial RNA processing#GO:0000963;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG185032|UniProtKB=T1FMB2 T1FMB2 20209961 PTHR45744:SF46 TYROSINE AMINOTRANSFERASE TYROSINE AMINOTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 transaminase#PC00216 Tyrosine biosynthesis#P02784>Aromatic amino acid aminotransferase#P03213 HELRO|EnsemblGenome=HelroG164523|UniProtKB=T1EVI8 T1EVI8 20200588 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG71864|UniProtKB=T1G0S5 T1G0S5 20214673 PTHR12442:SF11 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 1 binding#GO:0005488;protein binding#GO:0005515 microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cilium movement#GO:0003341;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;dynein complex#GO:0030286;axonemal dynein complex#GO:0005858;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;outer dynein arm#GO:0036157;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG181486|UniProtKB=T1FH20 T1FH20 20208119 PTHR14049:SF9 LEPRECAN 1 PROCOLLAGEN-PROLINE 3-DIOXYGENASE extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG188435|UniProtKB=T1FPZ5 T1FPZ5 20210892 PTHR13029:SF18 FAMILY NOT NAMED MYELIN REGULATORY FACTOR HOMOLOG 1 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565 positive regulation of biosynthetic process#GO:0009891;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biosynthetic process#GO:0009058;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;proteolysis#GO:0006508;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;metabolic process#GO:0008152;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;protein maturation#GO:0051604;gene expression#GO:0010467 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;nucleus#GO:0005634;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090 HELRO|EnsemblGenome=HelroG88841|UniProtKB=T1G770 T1G770 20216917 PTHR24416:SF634 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;signaling receptor activity#GO:0038023;kinase activity#GO:0016301;transferase activity#GO:0016740;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;collagen binding#GO:0005518;binding#GO:0005488 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of intracellular signal transduction#GO:1902531;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194847|UniProtKB=T1FWH3 T1FWH3 20213168 PTHR18861:SF5 ELKS/RAB6-INTERACTING/CAST PROTEIN PROTEIN BRUCHPILOT structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198 cellular process#GO:0009987;synapse organization#GO:0050808;cellular component organization#GO:0016043;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;cell cortex#GO:0005938;presynapse#GO:0098793;cytoplasm#GO:0005737;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;presynaptic active zone#GO:0048786;cell junction#GO:0030054 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG81270|UniProtKB=T1G4C3 T1G4C3 20215921 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG159597|UniProtKB=T1EP80 T1EP80 20198380 PTHR36170:SF1 CENTROSOMAL PROTEIN OF 89 KDA CENTROSOMAL PROTEIN OF 89 KDA plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;mitochondrion organization#GO:0007005;cell projection organization#GO:0030030;cellular component assembly#GO:0022607 ciliary transition fiber#GO:0097539;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;protein-containing complex#GO:0032991;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG155694|UniProtKB=T1ELK8 T1ELK8 20197458 PTHR11753:SF5 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG178781|UniProtKB=T1FDQ5 T1FDQ5 20206954 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD LICD_FKTN_FKRP NUCLEOTIDYLTRANSFERASE DOMAIN-CONTAINING PROTEIN transferase#PC00220 HELRO|EnsemblGenome=HelroG130334|UniProtKB=T1EHT6 T1EHT6 20196136 PTHR24211:SF20 LIM DOMAIN-CONTAINING PROTEIN PROTEIN ESPINAS-RELATED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179244|UniProtKB=T1FEF2 T1FEF2 20207201 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG183641|UniProtKB=T1FJZ2 T1FJZ2 20209141 PTHR18945:SF938 NEUROTRANSMITTER GATED ION CHANNEL PROTON-GATED ION CHANNEL ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG173801|UniProtKB=T1F788 T1F788 20204687 PTHR21600:SF40 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD2 catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;isomerase activity#GO:0016853 ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG103731|UniProtKB=T1EDH0 T1EDH0 20194622 PTHR43382:SF2 PROLYL-TRNA SYNTHETASE BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG187587|UniProtKB=T1FPA9 T1FPA9 20210656 PTHR11811:SF25 6-PHOSPHOGLUCONATE DEHYDROGENASE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING purine nucleotide binding#GO:0017076;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;phosphogluconate dehydrogenase (decarboxylating) activity#GO:0004616;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;nucleobase-containing compound metabolic process#GO:0006139;generation of precursor metabolites and energy#GO:0006091;pentose-phosphate shunt, oxidative branch#GO:0009051;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;pentose-phosphate shunt#GO:0006098;nucleotide metabolic process#GO:0009117 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 Pentose phosphate pathway#P02762>Gluconate Dehydrogenase#P03070 HELRO|EnsemblGenome=HelroG83339|UniProtKB=T1G544 T1G544 20216192 PTHR12013:SF0 SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN establishment of protein localization to endoplasmic reticulum#GO:0072599;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;protein targeting to ER#GO:0045047;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;intracellular transport#GO:0046907;protein targeting to membrane#GO:0006612;protein targeting#GO:0006605;protein transport#GO:0015031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;localization within membrane#GO:0051668 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185691|UniProtKB=T1FN56 T1FN56 20210254 PTHR13238:SF0 PROTEIN C21ORF59 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298 HELRO|EnsemblGenome=HelroG121951|UniProtKB=T1EGT3 T1EGT3 20195783 PTHR19444:SF13 UNC-93 RELATED N-ACETYLGLUCOSAMINE TRANSPORTER UNC93A channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG174108|UniProtKB=T1F7M2 T1F7M2 20204821 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG181386|UniProtKB=T1FGY3 T1FGY3 20208082 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 5 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168352|UniProtKB=T1F0G2 T1F0G2 20202312 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158374|UniProtKB=T1EMQ2 T1EMQ2 20197852 PTHR24044:SF417 NOTCH LIGAND FAMILY MEMBER WEARY, ISOFORM B protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG100036|UniProtKB=T1ECY3 T1ECY3 20194435 PTHR13123:SF7 LD30288P LD30288P cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG114601|UniProtKB=T1EG34 T1EG34 20195536 PTHR24276:SF99 POLYSERASE-RELATED AT26814P-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194496|UniProtKB=T1FW44 T1FW44 20213040 PTHR24104:SF51 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163596|UniProtKB=T1EU97 T1EU97 20200147 PTHR12424:SF8 TWEETY-RELATED PROTEIN TWEETY HOMOLOG 1 chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG125141|UniProtKB=T1EH45 T1EH45 20195895 PTHR13281:SF0 TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG76547|UniProtKB=T1G2L3 T1G2L3 20215311 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG72024|UniProtKB=T1G0U2 T1G0U2 20214690 PTHR10468:SF12 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69372|UniProtKB=T1FZU1 T1FZU1 20214339 PTHR24115:SF1030 KINESIN-RELATED KINESIN-LIKE PROTEIN UNC-104 protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631 axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;vesicle-mediated transport#GO:0016192;cytoskeleton-dependent intracellular transport#GO:0030705;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;transport#GO:0006810;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;cytosolic transport#GO:0016482;organelle localization#GO:0051640;axonal transport#GO:0098930;retrograde axonal transport#GO:0008090;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG108743|UniProtKB=T1EEM1 T1EEM1 20195023 PTHR12447:SF39 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of endocytosis#GO:0030100;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;late endosome#GO:0005770;plasma membrane#GO:0005886;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG100443|UniProtKB=T1ECZ8 T1ECZ8 20194450 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HELRO|EnsemblGenome=HelroG193237|UniProtKB=T1FUS1 T1FUS1 20212567 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174466|UniProtKB=T1F854 T1F854 20205003 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180906|UniProtKB=T1FGE4 T1FGE4 20207893 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG101329|UniProtKB=T1ED40 T1ED40 20194493 PTHR11203:SF11 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3 RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;5'-3' exonuclease activity#GO:0008409;hydrolase activity#GO:0016787;RNA binding#GO:0003723;exonuclease activity#GO:0004527;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG65571|UniProtKB=T1FYA0 T1FYA0 20213798 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG179644|UniProtKB=T1FEZ4 T1FEZ4 20207393 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG191118|UniProtKB=T1FSL9 T1FSL9 20211816 PTHR14948:SF25 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG143940|UniProtKB=T1EJD1 T1EJD1 20196681 PTHR16320:SF24 SPHINGOMYELINASE FAMILY MEMBER ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172158|UniProtKB=T1F531 T1F531 20203930 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191087|UniProtKB=T1FSK7 T1FSK7 20211804 PTHR11528:SF44 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP binding#GO:0005524 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 chaperone#PC00072;Hsp90 family chaperone#PC00028 HELRO|EnsemblGenome=HelroG192032|UniProtKB=T1FTI8 T1FTI8 20212135 PTHR12814:SF2 RNA-BINDING PROTEIN NOB1 RNA-BINDING PROTEIN NOB1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 protein-containing complex#GO:0032991;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG181602|UniProtKB=T1FH58 T1FH58 20208157 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185414|UniProtKB=T1FMS5 T1FMS5 20210124 PTHR10502:SF175 ANNEXIN ANNEXIN A13 phospholipid binding#GO:0005543;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;nucleus#GO:0005634;vesicle#GO:0031982;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG62277|UniProtKB=T1FWY4 T1FWY4 20213332 PTHR34932:SF1 TRPL TRANSLOCATION DEFECT PROTEIN 14 NADR_TTD14 AAA DOMAIN-CONTAINING PROTEIN ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;nucleotide binding#GO:0000166;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;lipid binding#GO:0008289;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 HELRO|EnsemblGenome=HelroG72578|UniProtKB=T1G121 T1G121 20214769 PTHR20961:SF148 GLYCOSYLTRANSFERASE EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG79987|UniProtKB=T1G3V9 T1G3V9 20215757 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG190273|UniProtKB=T1FRU6 T1FRU6 20211543 PTHR16266:SF17 WD REPEAT DOMAIN 9 BRWD3 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG113789|UniProtKB=T1EFW5 T1EFW5 20195467 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;positive regulation of organelle organization#GO:0010638;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG192684|UniProtKB=T1FU68 T1FU68 20212364 PTHR11652:SF14 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG69804|UniProtKB=T1FZY7 T1FZY7 20214385 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG174170|UniProtKB=T1F7Q5 T1F7Q5 20204854 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG159691|UniProtKB=T1EPB3 T1EPB3 20198413 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177055|UniProtKB=T1FB66 T1FB66 20206065 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188650|UniProtKB=T1FQ80 T1FQ80 20210977 PTHR12979:SF5 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;RNA metabolic process#GO:0016070;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;CCR4-NOT complex#GO:0030014 HELRO|EnsemblGenome=HelroG104268|UniProtKB=T1EDK7 T1EDK7 20194659 PTHR11359:SF0 AMP DEAMINASE AMP DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824 cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside phosphate biosynthetic process#GO:1901293;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;IMP metabolic process#GO:0046040;primary metabolic process#GO:0044238;IMP biosynthetic process#GO:0006188;organophosphate biosynthetic process#GO:0090407 deaminase#PC00088 Purine metabolism#P02769>5'-AMP Deaminase#P03117 HELRO|EnsemblGenome=HelroG84784|UniProtKB=T1G5N6 T1G5N6 20216383 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133 HELRO|EnsemblGenome=HelroG74006|UniProtKB=T1G1L0 T1G1L0 20214958 PTHR12890:SF0 DREV PROTEIN PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG177838|UniProtKB=T1FCC6 T1FCC6 20206475 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG163269|UniProtKB=T1ETU9 T1ETU9 20199999 PTHR10264:SF127 BAND 7 PROTEIN-RELATED BAND 7 PROTEIN CG42540 channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG91967|UniProtKB=T1G8B1 T1G8B1 20217308 PTHR12411:SF1058 CYSTEINE PROTEASE FAMILY C1-RELATED DIPEPTIDYL PEPTIDASE 1 cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;extracellular region#GO:0005576 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG103444|UniProtKB=T1EDG2 T1EDG2 20194614 PTHR24320:SF295 RETINOL DEHYDROGENASE PROTOCHLOROPHYLLIDE REDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG168355|UniProtKB=T1F0G4 T1F0G4 20202314 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG173523|UniProtKB=T1F6X7 T1F6X7 20204576 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181828|UniProtKB=T1FHD8 T1FHD8 20208237 PTHR24216:SF65 PAXILLIN-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG170068|UniProtKB=T1F2L6 T1F2L6 20203065 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174317|UniProtKB=T1F7Z6 T1F7Z6 20204945 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177867|UniProtKB=T1FCE1 T1FCE1 20206490 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED PROTEIN ROLLING STONE ISOFORM X1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG191951|UniProtKB=T1FTG0 T1FTG0 20212107 PTHR11132:SF558 SOLUTE CARRIER FAMILY 35 UDP-SUGAR TRANSPORTER UST74C antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 nitrogen compound transport#GO:0071705;nucleotide-sugar transmembrane transport#GO:0015780;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG109014|UniProtKB=T1EEQ0 T1EEQ0 20195052 PTHR22883:SF414 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC24-RELATED catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166089|UniProtKB=T1EXQ8 T1EXQ8 20201358 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG106350|UniProtKB=T1EE23 T1EE23 20194825 PTHR11081:SF8 FLAP ENDONUCLEASE FAMILY MEMBER EXONUCLEASE 1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HELRO|EnsemblGenome=HelroG185548|UniProtKB=T1FMZ0 T1FMZ0 20210189 PTHR11711:SF322 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 6 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553 intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036 cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein#PC00020 Integrin signalling pathway#P00034>Arf6#P00919;Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG114869|UniProtKB=T1EG51 T1EG51 20195553 PTHR12277:SF204 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PALMITOYL-PROTEIN HYDROLASE catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824 cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 serine protease#PC00203 HELRO|EnsemblGenome=HelroG63877|UniProtKB=T1FXL6 T1FXL6 20213564 PTHR43840:SF13 MITOCHONDRIAL METAL TRANSPORTER 1-RELATED CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG192917|UniProtKB=T1FUF4 T1FUF4 20212450 PTHR31932:SF3 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879;microtubule binding#GO:0008017;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;tubulin binding#GO:0015631 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG173127|UniProtKB=T1F6E8 T1F6E8 20204397 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88926|UniProtKB=T1G774 T1G774 20216921 PTHR14273:SF0 LYR MOTIF-CONTAINING PROTEIN 1 LYR MOTIF-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG192208|UniProtKB=T1FTP5 T1FTP5 20212192 PTHR21559:SF21 DYSTROGLYCAN-RELATED DYSTROGLYCAN 1 protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell projection morphogenesis#GO:0048858;morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection organization#GO:0120036;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;tissue development#GO:0009888;axon development#GO:0061564;axon guidance#GO:0007411;system development#GO:0048731;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;sarcolemma#GO:0042383 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG114528|UniProtKB=T1EG24 T1EG24 20195526 PTHR18860:SF184 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA scaffold/adaptor protein#PC00226 PI3 kinase pathway#P00048>14-3-3#P01206;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624;Parkinson disease#P00049>14-3-3#P01238 HELRO|EnsemblGenome=HelroG68712|UniProtKB=T1FZI7 T1FZI7 20214235 PTHR13417:SF2 E3 UBIQUITIN-PROTEIN LIGASE RNF146 E3 UBIQUITIN-PROTEIN LIGASE RNF146 ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;carbohydrate derivative binding#GO:0097367;transferase activity#GO:0016740;catalytic activity#GO:0003824 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG107293|UniProtKB=T1EE94 T1EE94 20194896 PTHR21600:SF81 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG71994|UniProtKB=T1G0T9 T1G0T9 20214687 PTHR19300:SF65 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG168594|UniProtKB=T1F0R9 T1F0R9 20202419 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG174211|UniProtKB=T1F7T0 T1F7T0 20204879 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993 HELRO|EnsemblGenome=HelroG176338|UniProtKB=T1FAE5 T1FAE5 20205794 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;vesicle#GO:0031982 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG99850|UniProtKB=T1G9V6 T1G9V6 20217852 PTHR11153:SF6 SIDEROFLEXIN SIDEROFLEXIN-5 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 mitochondrial transport#GO:0006839;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;intracellular transport#GO:0046907 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG166348|UniProtKB=T1EY16 T1EY16 20201466 PTHR48112:SF40 HIGH MOBILITY GROUP PROTEIN DSP1 HMG BOX DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG77867|UniProtKB=T1G350 T1G350 20215498 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216 cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG105872|UniProtKB=T1EDY0 T1EDY0 20194782 PTHR19846:SF0 WD40 REPEAT PROTEIN U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4 RNA processing factor#PC00147;RNA splicing factor#PC00148 mRNA splicing#P00058>U6#P01473;mRNA splicing#P00058>U4#P01476 HELRO|EnsemblGenome=HelroG176603|UniProtKB=T1FAP9 T1FAP9 20205898 PTHR11202:SF38 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;system development#GO:0048731;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;actin polymerization or depolymerization#GO:0008154;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;actin filament organization#GO:0007015;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell-substrate junction#GO:0030055;cell projection#GO:0042995;focal adhesion#GO:0005925;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;filopodium#GO:0030175;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG62089|UniProtKB=T1FWV5 T1FWV5 20213303 PTHR31296:SF1 UPF0565 PROTEIN C2ORF69 MITOCHONDRIAL PROTEIN C2ORF69 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG178035|UniProtKB=T1FCN2 T1FCN2 20206581 PTHR12011:SF481 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75114|UniProtKB=T1G210 T1G210 20215108 PTHR11566:SF67 DYNAMIN DYNAMIN-LIKE GTPASE OPA1, MITOCHONDRIAL protein binding#GO:0005515;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;microtubule binding#GO:0008017;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;organelle fusion#GO:0048284;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;mitochondrial fusion#GO:0008053;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;microtubule cytoskeleton#GO:0015630;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;mitochondrial intermembrane space#GO:0005758 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192879|UniProtKB=T1FUD9 T1FUD9 20212435 PTHR45975:SF2 NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF HELRO|EnsemblGenome=HelroG188891|UniProtKB=T1FQG2 T1FQG2 20211059 PTHR11370:SF6 DNA-REPAIR PROTEIN XRCC1 DNA REPAIR PROTEIN XRCC1 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;base-excision repair#GO:0006284;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG126544|UniProtKB=T1EHA3 T1EHA3 20195953 PTHR10986:SF16 39S RIBOSOMAL PROTEIN L20 LARGE RIBOSOMAL SUBUNIT PROTEIN BL20M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG105102|UniProtKB=T1EDQ8 T1EDQ8 20194710 PTHR10953:SF3 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7 ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;Atg12 activating enzyme activity#GO:0019778;transferase activity, transferring sulphur-containing groups#GO:0016782;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;response to starvation#GO:0042594;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;vacuole organization#GO:0007033;organelle assembly#GO:0070925;macroautophagy#GO:0016236;post-translational protein modification#GO:0043687;response to nutrient levels#GO:0031667;mitophagy#GO:0000423;macromolecule metabolic process#GO:0043170;cellular response to starvation#GO:0009267;autophagy of mitochondrion#GO:0000422;cellular response to nutrient levels#GO:0031669;response to stimulus#GO:0050896;cellular component organization#GO:0016043;protein modification by small protein conjugation#GO:0032446;process utilizing autophagic mechanism#GO:0061919;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;phagophore assembly site#GO:0000407 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG88302|UniProtKB=T1G713 T1G713 20216860 PTHR10974:SF78 FI08016P-RELATED FI21235P1 HELRO|EnsemblGenome=HelroG81437|UniProtKB=T1G4E3 T1G4E3 20215941 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG108883|UniProtKB=T1EEN4 T1EEN4 20195036 PTHR13462:SF10 CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;passive transmembrane transporter activity#GO:0022803;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 metal ion transport#GO:0030001;homeostatic process#GO:0042592;mitochondrial calcium ion homeostasis#GO:0051560;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003 organelle membrane#GO:0031090;transporter complex#GO:1990351;cation channel complex#GO:0034703;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 HELRO|EnsemblGenome=HelroG174775|UniProtKB=T1F8G4 T1F8G4 20205113 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185625|UniProtKB=T1FN21 T1FN21 20210220 PTHR11056:SF0 HOMOGENTISATE 1,2-DIOXYGENASE HOMOGENTISATE 1,2-DIOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG171207|UniProtKB=T1F3X9 T1F3X9 20203528 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023;hormone binding#GO:0042562;binding#GO:0005488 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167061|UniProtKB=T1EYY8 T1EYY8 20201788 PTHR19972:SF16 CALBINDIN CALBINDIN-32 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuron projection terminus#GO:0044306;distal axon#GO:0150034;terminal bouton#GO:0043195;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;cytosol#GO:0005829;neuron projection#GO:0043005;presynapse#GO:0098793;nucleus#GO:0005634;cell junction#GO:0030054;axon terminus#GO:0043679 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG171884|UniProtKB=T1F4T0 T1F4T0 20203829 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG186168|UniProtKB=T1FNR5 T1FNR5 20210462 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194380|UniProtKB=T1FW00 T1FW00 20212996 PTHR13466:SF0 TEX2 PROTEIN-RELATED SMP-LTD DOMAIN-CONTAINING PROTEIN binding#GO:0005488;lipid binding#GO:0008289 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG192191|UniProtKB=T1FTP0 T1FTP0 20212187 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG186525|UniProtKB=T1FP06 T1FP06 20210553 PTHR13140:SF713 MYOSIN UNCONVENTIONAL MYOSIN ID cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 actin filament-based process#GO:0030029;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based movement#GO:0030048;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cytoskeleton organization#GO:0007010 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cell periphery#GO:0071944;membrane#GO:0016020;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microvillus#GO:0005902;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG62415|UniProtKB=T1FX02 T1FX02 20213350 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790 transferase#PC00220 HELRO|EnsemblGenome=HelroG164848|UniProtKB=T1EVW0 T1EVW0 20200710 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG162528|UniProtKB=T1EST0 T1EST0 20199630 PTHR13710:SF162 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q1 nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724 chromosome#GO:0005694;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG79600|UniProtKB=T1G3Q6 T1G3Q6 20215704 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75396|UniProtKB=T1G246 T1G246 20215144 PTHR13134:SF3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG109499|UniProtKB=T1EEU3 T1EEU3 20195095 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;system process#GO:0003008;developmental process#GO:0032502;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;contractile muscle fiber#GO:0043292;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG62144|UniProtKB=T1FWW2 T1FWW2 20213310 PTHR20903:SF0 PREFOLDIN SUBUNIT 1-RELATED PREFOLDIN SUBUNIT 1 biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG182409|UniProtKB=T1FI56 T1FI56 20208505 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402 HELRO|EnsemblGenome=HelroG70596|UniProtKB=T1G091 T1G091 20214489 PTHR46095:SF1 ZINC FINGER PROTEIN 593 ZINC FINGER PROTEIN 593 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG149122|UniProtKB=T1EKC4 T1EKC4 20197024 PTHR12166:SF8 CALCIUM-DEPENDENT SECRETION ACTIVATOR CALCIUM-DEPENDENT SECRETION ACTIVATOR cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG105203|UniProtKB=T1EDR6 T1EDR6 20194718 PTHR11365:SF2 5-OXOPROLINASE RELATED 5-OXOPROLINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824 sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG91059|UniProtKB=T1G7Z2 T1G7Z2 20217189 PTHR12010:SF2 40S RIBOSOMAL PROTEIN S29 SMALL RIBOSOMAL SUBUNIT PROTEIN US14 zinc ion binding#GO:0008270;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG79716|UniProtKB=T1G3S7 T1G3S7 20215725 PTHR10314:SF194 CYSTATHIONINE BETA-SYNTHASE CYSTATHIONINE BETA-SYNTHASE hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;lyase#PC00144 Cysteine biosynthesis#P02737>O-Acetylserine-lyase#P02887 HELRO|EnsemblGenome=HelroG190158|UniProtKB=T1FRR1 T1FRR1 20211508 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG62159|UniProtKB=T1FWW4 T1FWW4 20213312 PTHR24372:SF80 GLYCOPROTEIN HORMONE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG182835|UniProtKB=T1FIU2 T1FIU2 20208741 PTHR11567:SF211 ACID PHOSPHATASE-RELATED ACID PHOSPHATASE catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG113615|UniProtKB=T1EFU2 T1EFU2 20195444 PTHR13501:SF10 CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG166966|UniProtKB=T1EYT7 T1EYT7 20201737 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183364|UniProtKB=T1FJI5 T1FJI5 20208984 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192174|UniProtKB=T1FTN6 T1FTN6 20212183 PTHR20957:SF0 RNA-BINDING PROTEIN 48 RNA-BINDING PROTEIN 48 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG98900|UniProtKB=T1G9Q2 T1G9Q2 20217798 PTHR10529:SF262 AP COMPLEX SUBUNIT MU ADAPTOR PROTEIN COMPLEX 1, MU SUBUNIT cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;cellular localization#GO:0051641;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810 Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;intracellular vesicle#GO:0097708;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane coat#GO:0030117;AP-1 adaptor complex#GO:0030121;trans-Golgi network transport vesicle#GO:0030140;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle membrane#GO:0031090;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG111897|UniProtKB=T1EFF5 T1EFF5 20195307 PTHR10901:SF6 TROPOMODULIN TROPOMODULIN, ISOFORM N protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 cellular developmental process#GO:0048869;actin filament organization#GO:0007015;system process#GO:0003008;muscle contraction#GO:0006936;developmental process#GO:0032502;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012 actin cytoskeleton#GO:0015629;contractile muscle fiber#GO:0043292;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG177639|UniProtKB=T1FBZ6 T1FBZ6 20206345 PTHR48043:SF168 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG80178|UniProtKB=T1G3Y6 T1G3Y6 20215784 PTHR11575:SF48 5'-NUCLEOTIDASE-RELATED ECTO-5'-NUCLEOTIDASE extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG185638|UniProtKB=T1FN27 T1FN27 20210226 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG185346|UniProtKB=T1FMP8 T1FMP8 20210097 PTHR28525:SF1 REACTIVE OXYGEN SPECIES MODULATOR 1 REACTIVE OXYGEN SPECIES MODULATOR 1 cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;protein insertion into mitochondrial inner membrane#GO:0045039;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;intracellular protein localization#GO:0008104 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG184165|UniProtKB=T1FKP6 T1FKP6 20209395 PTHR31395:SF25 SHISA PROTEIN SHISA-5-LIKE ISOFORM X1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179480|UniProtKB=T1FES0 T1FES0 20207319 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188978|UniProtKB=T1FQJ0 T1FQJ0 20211087 PTHR42765:SF3 SOLEUCYL-TRNA SYNTHETASE ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG157283|UniProtKB=T1EM88 T1EM88 20197688 PTHR11593:SF10 60S RIBOSOMAL PROTEIN L17 LARGE RIBOSOMAL SUBUNIT PROTEIN UL22 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG181869|UniProtKB=T1FHE9 T1FHE9 20208248 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED guanyl nucleotide binding#GO:0019001;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198 microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HELRO|EnsemblGenome=HelroG176375|UniProtKB=T1FAG4 T1FAG4 20205813 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171258|UniProtKB=T1F400 T1F400 20203549 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111022|UniProtKB=T1EF71 T1EF71 20195223 PTHR45919:SF1 GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75869|UniProtKB=T1G2B8 T1G2B8 20215216 PTHR13568:SF9 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 203 monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;calcium ion homeostasis#GO:0055074;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG156424|UniProtKB=T1ELW2 T1ELW2 20197562 PTHR15599:SF1 RTDR1 RADIAL SPOKE HEAD 14 HOMOLOG HELRO|EnsemblGenome=HelroG112993|UniProtKB=T1EFP3 T1EFP3 20195395 PTHR23316:SF71 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;cellular localization#GO:0051641;protein localization to organelle#GO:0033365 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG117043|UniProtKB=T1EGJ6 T1EGJ6 20195698 PTHR11963:SF23 LEUCINE AMINOPEPTIDASE-RELATED CYTOSOL AMINOPEPTIDASE peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG65555|UniProtKB=T1FY95 T1FY95 20213793 PTHR16105:SF0 RNA-BINDING REGION-CONTAINING PROTEIN 3 RNA-BINDING REGION-CONTAINING PROTEIN 3 nucleic acid binding#GO:0003676;pre-mRNA binding#GO:0036002;binding#GO:0005488;RNA binding#GO:0003723;snRNA binding#GO:0017069 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG171810|UniProtKB=T1F4Q1 T1F4Q1 20203800 PTHR44592:SF3 NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN RNA LIGASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157613|UniProtKB=T1EMD9 T1EMD9 20197739 PTHR13256:SF16 N-ACETYLTRANSFERASE 9 ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9 protein N-acyltransferase activity#GO:0140186;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of microtubule polymerization or depolymerization#GO:0031110;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of protein polymerization#GO:0032273;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of organelle organization#GO:0010638;regulation of microtubule polymerization#GO:0031113;regulation of microtubule-based process#GO:0032886;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cellular component biogenesis#GO:0044087;regulation of protein-containing complex assembly#GO:0043254;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG159391|UniProtKB=T1ENZ7 T1ENZ7 20198297 PTHR12673:SF159 FACIOGENITAL DYSPLASIA PROTEIN LD03170P guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG167366|UniProtKB=T1EZB2 T1EZB2 20201912 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;binding#GO:0005488;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202;response to stimulus#GO:0050896;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183261|UniProtKB=T1FJD9 T1FJD9 20208938 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171179|UniProtKB=T1F3W6 T1F3W6 20203515 PTHR35081:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 105 TEKTIN-LIKE PROTEIN 1 HELRO|EnsemblGenome=HelroG184107|UniProtKB=T1FKL3 T1FKL3 20209362 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG69014|UniProtKB=T1FZN5 T1FZN5 20214283 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173689|UniProtKB=T1F743 T1F743 20204642 PTHR11673:SF6 TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 5A translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG144922|UniProtKB=T1EJH1 T1EJH1 20196721 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG189940|UniProtKB=T1FRI4 T1FRI4 20211431 PTHR11640:SF31 NEPHRIN MIP08606P binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 anchoring junction#GO:0070161;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG175281|UniProtKB=T1F938 T1F938 20205337 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157041|UniProtKB=T1EM53 T1EM53 20197653 PTHR11994:SF8 60S RIBOSOMAL PROTEIN L11-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL5 binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG82145|UniProtKB=T1G4N6 T1G4N6 20216034 PTHR11477:SF53 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN IP08861P-RELATED transcription regulator activity#GO:0140110;transcription elongation factor activity#GO:0003711 transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription elongation#GO:0006354;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG186192|UniProtKB=T1FNS8 T1FNS8 20210475 PTHR19300:SF65 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG191499|UniProtKB=T1FT16 T1FT16 20211963 PTHR33590:SF4 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113378|UniProtKB=T1EFS1 T1EFS1 20195423 PTHR12731:SF1 TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG168599|UniProtKB=T1F0S2 T1F0S2 20202422 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HELRO|EnsemblGenome=HelroG170808|UniProtKB=T1F3G5 T1F3G5 20203364 PTHR22906:SF55 PROPERDIN EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167851|UniProtKB=T1EZV7 T1EZV7 20202107 PTHR13280:SF17 PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN KRUEPPEL TARGET AT 95D, ISOFORM A protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 HELRO|EnsemblGenome=HelroG185175|UniProtKB=T1FMH0 T1FMH0 20210019 PTHR24031:SF790 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG176349|UniProtKB=T1FAF0 T1FAF0 20205799 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG71670|UniProtKB=T1G0P9 T1G0P9 20214647 PTHR23404:SF2 MOLYBDOPTERIN SYNTHASE RELATED MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG181629|UniProtKB=T1FH69 T1FH69 20208168 PTHR10390:SF33 HOMEOBOX PROTEIN SIX PROTEIN OPTIX DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG81689|UniProtKB=T1G4H5 T1G4H5 20215973 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG150702|UniProtKB=T1EKH0 T1EKH0 20197070 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 establishment of localization#GO:0051234;carbohydrate transmembrane transport#GO:0034219;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transport#GO:0008643 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG82229|UniProtKB=T1G4P5 T1G4P5 20216043 PTHR24064:SF445 SOLUTE CARRIER FAMILY 22 MEMBER AT15560P-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG132940|UniProtKB=T1EI00 T1EI00 20196200 PTHR45911:SF10 C2 DOMAIN-CONTAINING PROTEIN MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 regulation of secretion#GO:0051046;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;regulation of neurotransmitter secretion#GO:0046928;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;presynapse#GO:0098793;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG192742|UniProtKB=T1FU91 T1FU91 20212387 PTHR23043:SF39 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA DYSFUSION, ISOFORM D sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG186190|UniProtKB=T1FNS6 T1FNS6 20210473 PTHR46340:SF1 UBX DOMAIN-CONTAINING PROTEIN 1 UBX DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;modification-dependent protein binding#GO:0140030 negative regulation of cellular process#GO:0048523;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of protein ubiquitination#GO:0031396;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;regulation of catabolic process#GO:0009894;regulation of protein modification process#GO:0031399;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;negative regulation of protein ubiquitination#GO:0031397;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of post-translational protein modification#GO:1901873;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of protein modification by small protein conjugation or removal#GO:1903320;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of proteasomal protein catabolic process#GO:1901799 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG189266|UniProtKB=T1FQW1 T1FQW1 20211208 PTHR14159:SF0 ATAXIN-3-RELATED ATAXIN-3-RELATED ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;negative regulation of biological process#GO:0048519;negative regulation of TORC1 signaling#GO:1904262;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;regulation of protein metabolic process#GO:0051246;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;protein metabolic process#GO:0019538;regulation of ERAD pathway#GO:1904292;regulation of cell communication#GO:0010646;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;regulation of response to endoplasmic reticulum stress#GO:1905897;primary metabolic process#GO:0044238;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG91686|UniProtKB=T1G880 T1G880 20217277 PTHR11627:SF80 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;aldehyde-lyase activity#GO:0016832;fructose-bisphosphate aldolase activity#GO:0004332;lyase activity#GO:0016829 pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleotide catabolic process#GO:0009166;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;ADP catabolic process#GO:0046032;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine-containing compound catabolic process#GO:0072523;nicotinamide nucleotide metabolic process#GO:0046496;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 aldolase#PC00044;lyase#PC00144 Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959;Glycolysis#P00024>Aldolase#P00679 HELRO|EnsemblGenome=HelroG177041|UniProtKB=T1FB62 T1FB62 20206061 PTHR12665:SF7 ORMDL PROTEINS ORM1-LIKE PROTEIN ceramide metabolic process#GO:0006672;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;cellular process#GO:0009987 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG65325|UniProtKB=T1FY63 T1FY63 20213761 PTHR21451:SF0 HISTONE H3 METHYLTRANSFERASE HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;heterochromatin formation#GO:0031507;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;DNA damage checkpoint signaling#GO:0000077;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;DNA integrity checkpoint signaling#GO:0031570;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;response to stimulus#GO:0050896;chromatin remodeling#GO:0006338;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cellular response to stress#GO:0033554;cellular component assembly#GO:0022607;cell cycle checkpoint signaling#GO:0000075;heterochromatin organization#GO:0070828;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;constitutive heterochromatin formation#GO:0140719;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG159076|UniProtKB=T1ENK1 T1ENK1 20198151 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG161437|UniProtKB=T1ERH1 T1ERH1 20199171 PTHR33137:SF53 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED SUBFAMILY NOT NAMED ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161402|UniProtKB=T1ERG0 T1ERG0 20199160 PTHR10696:SF51 GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706 modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987;carnitine metabolic process#GO:0009437;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 hydroxylase#PC00122;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194777|UniProtKB=T1FWE3 T1FWE3 20213138 PTHR14107:SF24 WD REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 20 HOMOLOG peptidase regulator activity#GO:0061134;peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;negative regulation of protein catabolic process#GO:0042177;biological regulation#GO:0065007;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;regulation of catabolic process#GO:0009894;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG176482|UniProtKB=T1FAK3 T1FAK3 20205852 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88577|UniProtKB=T1G739 T1G739 20216886 PTHR21575:SF12 PROTEIN HID1 PROTEIN HID1 vesicle organization#GO:0016050;anatomical structure development#GO:0048856;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;endomembrane system organization#GO:0010256;developmental maturation#GO:0021700;cellular process#GO:0009987;anatomical structure maturation#GO:0071695;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytosol#GO:0005829;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG98619|UniProtKB=T1G9N8 T1G9N8 20217784 PTHR24339:SF28 HOMEOBOX PROTEIN EMX-RELATED E5-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;head development#GO:0060322;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG105637|UniProtKB=T1EDW9 T1EDW9 20194771 PTHR12904:SF23 FAMILY NOT NAMED PROTEIN ZER-1 HOMOLOG transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG129823|UniProtKB=T1EHS4 T1EHS4 20196124 PTHR24391:SF30 HISTONE H4 TRANSCRIPTION FACTOR-RELATED EG:115C2.6 PROTEIN RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG183688|UniProtKB=T1FK15 T1FK15 20209164 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG158464|UniProtKB=T1EMT8 T1EMT8 20197888 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71625|UniProtKB=T1G0P2 T1G0P2 20214640 PTHR46229:SF2 BOLA TRANSCRIPTION REGULATOR BOLA-LIKE PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG188157|UniProtKB=T1FPQ0 T1FPQ0 20210797 PTHR13434:SF0 PROTEIN CASC3 PROTEIN CASC3 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145 HELRO|EnsemblGenome=HelroG160533|UniProtKB=T1EQD4 T1EQD4 20198784 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG87104|UniProtKB=T1G6L7 T1G6L7 20216714 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84604|UniProtKB=T1G5K7 T1G5K7 20216354 PTHR24543:SF339 MULTICOPPER OXIDASE-RELATED LACTADHERIN-LIKE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG119364|UniProtKB=T1EGN0 T1EGN0 20195730 PTHR10110:SF201 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;import into cell#GO:0098657;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659 membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;recycling endosome#GO:0055037;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG162754|UniProtKB=T1ET32 T1ET32 20199732 PTHR13211:SF1 TELOMERASE CAJAL BODY PROTEIN 1 TELOMERASE CAJAL BODY PROTEIN 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG68492|UniProtKB=T1FZF6 T1FZF6 20214204 PTHR10701:SF5 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG165877|UniProtKB=T1EXE2 T1EXE2 20201242 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG162187|UniProtKB=T1ESC2 T1ESC2 20199472 PTHR23353:SF34 RAB-GAP/TBC-RELATED TBC1 DOMAIN FAMILY MEMBER 24 GTPase-activating protein#PC00257 N-acetylglucosamine metabolism#P02756>N-acetylglucosamine-6-phosphate deacetylase#P03036 HELRO|EnsemblGenome=HelroG162789|UniProtKB=T1ET56 T1ET56 20199756 PTHR10155:SF16 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 2-LIKE PROTEIN protein binding#GO:0005515;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of signaling#GO:0023051;cytokine-mediated signaling pathway#GO:0019221;negative regulation of signaling#GO:0023057;response to peptide#GO:1901652;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;response to chemical#GO:0042221;response to cytokine#GO:0034097 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG64773|UniProtKB=T1FXZ1 T1FXZ1 20213689 PTHR22804:SF57 AGGRECAN/VERSICAN PROTEOGLYCAN NEUROGENIC LOCUS NOTCH PROTEIN extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 Alzheimer disease-presenilin pathway#P00004>NICD#P00122;Alzheimer disease-presenilin pathway#P00004>Notch extracellular fragment#P00179;Alzheimer disease-presenilin pathway#P00004>Notch transmembrane fragment#P00135;Alzheimer disease-presenilin pathway#P00004>Notch C-terminal fragment#P00120;Alzheimer disease-presenilin pathway#P00004>Notch fragment#P00154;Alzheimer disease-presenilin pathway#P00004>Notch#P00176;Alzheimer disease-presenilin pathway#P00004>Notch N-terminal fragment#P00171;Angiogenesis#P00005>Notch#P00255 HELRO|EnsemblGenome=HelroG194143|UniProtKB=T1FVR4 T1FVR4 20212910 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG113446|UniProtKB=T1EFS6 T1EFS6 20195428 PTHR12202:SF0 ESF1 HOMOLOG ESF1 HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HELRO|EnsemblGenome=HelroG110527|UniProtKB=T1EF31 T1EF31 20195183 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG62724|UniProtKB=T1FX40 T1FX40 20213388 PTHR22722:SF17 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR ISOFORM X1 HELRO|EnsemblGenome=HelroG158621|UniProtKB=T1EN07 T1EN07 20197957 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG159942|UniProtKB=T1EPL1 T1EPL1 20198511 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG193292|UniProtKB=T1FUU4 T1FUU4 20212590 PTHR10075:SF130 BASIGIN RELATED NEURAL CELL ADHESION MOLECULE L1 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG185038|UniProtKB=T1FMB4 T1FMB4 20209963 PTHR13395:SF6 SISTER CHROMATID COHESION PROTEIN DCC1-RELATED SISTER CHROMATID COHESION PROTEIN DCC1 mitotic sister chromatid cohesion#GO:0007064;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG120046|UniProtKB=T1EGP4 T1EGP4 20195744 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR MELATONIN RECEPTOR PDCR-1 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185381|UniProtKB=T1FMQ9 T1FMQ9 20210108 PTHR12753:SF6 AD-003 - RELATED ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1 catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG80369|UniProtKB=T1G3Z8 T1G3Z8 20215796 PTHR45706:SF4 TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG63243|UniProtKB=T1FXC8 T1FXC8 20213476 PTHR11360:SF325 MONOCARBOXYLATE TRANSPORTER EG:103B4.3 PROTEIN carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monocarboxylic acid transmembrane transporter activity#GO:0008028 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG67069|UniProtKB=T1FYV9 T1FYV9 20214007 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;metal ion transport#GO:0030001;action potential#GO:0001508 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG69120|UniProtKB=T1FZP9 T1FZP9 20214297 PTHR23048:SF66 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN 2 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG177894|UniProtKB=T1FCF8 T1FCF8 20206507 PTHR46199:SF3 RAC GTPASE-ACTIVATING PROTEIN 1 RAC GTPASE-ACTIVATING PROTEIN 1 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;signaling#GO:0023052;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;cytokinesis#GO:0000910;nuclear division#GO:0000280;cytoskeleton-dependent cytokinesis#GO:0061640;Rho protein signal transduction#GO:0007266;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;intracellular signaling cassette#GO:0141124;spindle elongation#GO:0051231;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular response to stimulus#GO:0051716;cell division#GO:0051301;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;mitotic cytokinesis#GO:0000281;organelle assembly#GO:0070925;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;mitotic spindle assembly#GO:0090307;mitotic sister chromatid segregation#GO:0000070;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;spindle organization#GO:0007051 plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;cleavage furrow#GO:0032154;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;spindle#GO:0005819;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;midbody#GO:0030496;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;intracellular organelle#GO:0043229 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG178140|UniProtKB=T1FCT8 T1FCT8 20206637 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG135084|UniProtKB=T1EI69 T1EI69 20196269 PTHR14021:SF20 IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;ATPase activator activity#GO:0001671 cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;iron-sulfur cluster assembly#GO:0016226 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG172932|UniProtKB=T1F656 T1F656 20204305 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164424|UniProtKB=T1EVE5 T1EVE5 20200545 PTHR46948:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P38 RIBONUCLEASE P PROTEIN SUBUNIT P38 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG80739|UniProtKB=T1G447 T1G447 20215845 PTHR11829:SF363 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN TRANSCRIPTION FACTOR SLP1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG106294|UniProtKB=T1EE15 T1EE15 20194817 PTHR12537:SF195 RNA BINDING PROTEIN PUMILIO-RELATED MATERNAL PROTEIN PUMILIO mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185020|UniProtKB=T1FMA5 T1FMA5 20209954 PTHR10351:SF23 TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER TRANSCRIPTION FACTOR BTF3 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG178793|UniProtKB=T1FDR1 T1FDR1 20206960 PTHR11431:SF75 FERRITIN FERRITIN iron ion binding#GO:0005506;ferrous iron binding#GO:0008198;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 storage protein#PC00210 HELRO|EnsemblGenome=HelroG63192|UniProtKB=T1FXB9 T1FXB9 20213467 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate derivative binding#GO:0097367;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740 organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase#PC00137;carbohydrate kinase#PC00065;transferase#PC00220 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG155947|UniProtKB=T1ELP5 T1ELP5 20197495 PTHR32179:SF3 NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nicotinamide nucleotide metabolic process#GO:0046496;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;purine nucleotide biosynthetic process#GO:0006164;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753 HELRO|EnsemblGenome=HelroG62517|UniProtKB=T1FX18 T1FX18 20213366 PTHR11584:SF369 SERINE/THREONINE PROTEIN KINASE APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;JNK cascade#GO:0007254;response to stimulus#GO:0050896;p38MAPK cascade#GO:0038066;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>MEKK1-5#P00553;FGF signaling pathway#P00021>MEKK1-5#P00634 HELRO|EnsemblGenome=HelroG178617|UniProtKB=T1FDG6 T1FDG6 20206865 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173990|UniProtKB=T1F7G4 T1F7G4 20204763 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG184152|UniProtKB=T1FKP2 T1FKP2 20209391 PTHR12381:SF56 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;alternative mRNA splicing, via spliceosome#GO:0000380;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG85425|UniProtKB=T1G5W9 T1G5W9 20216466 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 carbohydrate transport#GO:0008643;cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;carbohydrate transmembrane transport#GO:0034219 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG173210|UniProtKB=T1F6K7 T1F6K7 20204456 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189813|UniProtKB=T1FRE0 T1FRE0 20211387 PTHR11472:SF47 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER FANCONI ANEMIA GROUP J PROTEIN ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;nucleotide-excision repair#GO:0006289;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;response to stimulus#GO:0050896;nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;reproductive process#GO:0022414;homologous recombination#GO:0035825;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG88417|UniProtKB=T1G722 T1G722 20216869 PTHR12765:SF5 RED PROTEIN IK FACTOR CYTOKINE IK PROTEIN RED macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytokine#PC00083 HELRO|EnsemblGenome=HelroG192002|UniProtKB=T1FTI0 T1FTI0 20212127 PTHR19302:SF33 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 5 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 cell cycle process#GO:0022402;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;reproductive process#GO:0022414;cytoplasmic microtubule organization#GO:0031122;mitotic cell cycle#GO:0000278;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG188929|UniProtKB=T1FQH6 T1FQH6 20211073 PTHR10378:SF50 LIM DOMAIN-BINDING PROTEIN CHIP, ISOFORM B transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;animal gross anatomical part developmental process#GO:0160108;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG68856|UniProtKB=T1FZK4 T1FZK4 20214252 PTHR43782:SF5 ARGINASE ARGINASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;transition metal ion binding#GO:0046914;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;hydrolase activity#GO:0016787;metal ion binding#GO:0046872 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182716|UniProtKB=T1FIM9 T1FIM9 20208678 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169068|UniProtKB=T1F1C9 T1F1C9 20202629 PTHR24351:SF234 RIBOSOMAL PROTEIN S6 KINASE SERINE_THREONINE-PROTEIN KINASE YPK2_YKR2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76071|UniProtKB=T1G2E6 T1G2E6 20215244 PTHR12072:SF5 CWF19, CELL CYCLE CONTROL PROTEIN CWF19-LIKE PROTEIN 2 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG68110|UniProtKB=T1FZA3 T1FZA3 20214151 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG111769|UniProtKB=T1EFE3 T1EFE3 20195295 PTHR20963:SF56 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 intracellular organelle#GO:0043229;extracellular region#GO:0005576;endoplasmic reticulum#GO:0005783;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG177323|UniProtKB=T1FBH9 T1FBH9 20206178 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG180680|UniProtKB=T1FG59 T1FG59 20207808 PTHR42912:SF83 METHYLTRANSFERASE METHYLTRANSFERASE OMS1, MITOCHONDRIAL methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG159372|UniProtKB=T1ENY7 T1ENY7 20198287 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR MELATONIN RECEPTOR PDCR-1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;biological regulation#GO:0065007;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG194751|UniProtKB=T1FWD3 T1FWD3 20213128 PTHR28559:SF1 DNA REPAIR PROTEIN XRCC4 RE59279P cellular response to stimulus#GO:0051716;response to ionizing radiation#GO:0010212;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to radiation#GO:0009314;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nonhomologous end joining complex#GO:0070419;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;DNA repair complex#GO:1990391 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG67144|UniProtKB=T1FYX4 T1FYX4 20214022 PTHR16058:SF5 DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 DZANK-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193192|UniProtKB=T1FUQ4 T1FUQ4 20212550 PTHR24020:SF20 COLLAGEN ALPHA PH DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG77563|UniProtKB=T1G2Z9 T1G2Z9 20215447 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170907|UniProtKB=T1F3L0 T1F3L0 20203409 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG85674|UniProtKB=T1G614 T1G614 20216511 PTHR10264:SF127 BAND 7 PROTEIN-RELATED BAND 7 PROTEIN CG42540 ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG188342|UniProtKB=T1FPW6 T1FPW6 20210863 PTHR10334:SF517 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG188241|UniProtKB=T1FPT0 T1FPT0 20210827 PTHR13462:SF10 CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;passive transmembrane transporter activity#GO:0022803;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;mitochondrial calcium ion homeostasis#GO:0051560;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;transporter complex#GO:1990351;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG180615|UniProtKB=T1FG34 T1FG34 20207783 PTHR11954:SF49 D-DOPACHROME DECARBOXYLASE MACROPHAGE MIGRATION INHIBITORY FACTOR catalytic activity#GO:0003824;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;isomerase activity#GO:0016853;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;intramolecular oxidoreductase activity#GO:0016860;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262;lyase#PC00144 HELRO|EnsemblGenome=HelroG166893|UniProtKB=T1EYQ0 T1EYQ0 20201700 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93683|UniProtKB=T1G8X4 T1G8X4 20217521 PTHR28524:SF3 SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL chaperone#PC00072 HELRO|EnsemblGenome=HelroG74022|UniProtKB=T1G1L3 T1G1L3 20214961 PTHR16515:SF88 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG194048|UniProtKB=T1FVM1 T1FVM1 20212867 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG75311|UniProtKB=T1G235 T1G235 20215133 PTHR48620:SF1 TAX1-BINDING PROTEIN 3 TAX1-BINDING PROTEIN 3 HELRO|EnsemblGenome=HelroG66584|UniProtKB=T1FYM9 T1FYM9 20213927 PTHR12111:SF1 SPLICING FACTOR YJU2 SPLICING FACTOR YJU2 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG160567|UniProtKB=T1EQF5 T1EQF5 20198805 PTHR12483:SF115 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN transition metal ion transmembrane transporter activity#GO:0046915;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873 cellular process#GO:0009987;copper ion transmembrane transport#GO:0035434;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;transition metal ion transport#GO:0000041;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG103772|UniProtKB=T1EDH4 T1EDH4 20194626 PTHR14950:SF82 DICER-RELATED ENDORIBONUCLEASE DICER binding#GO:0005488;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;nucleic acid binding#GO:0003676;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity#GO:0003824;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540 negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of cellular process#GO:0050794;pre-miRNA processing#GO:0031054;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;programmed cell death#GO:0012501;cell death#GO:0008219;gene expression#GO:0010467;apoptotic DNA fragmentation#GO:0006309;RNA processing#GO:0006396;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;siRNA processing#GO:0030422;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;execution phase of apoptosis#GO:0097194;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070;DNA catabolic process#GO:0006308;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG64447|UniProtKB=T1FXV1 T1FXV1 20213649 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG156368|UniProtKB=T1ELU5 T1ELU5 20197545 PTHR11915:SF422 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036 membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG190477|UniProtKB=T1FS07 T1FS07 20211604 PTHR12444:SF8 PROTEIN EFR3 HOMOLOG CMP44E PROTEIN EFR3 HOMOLOG CMP44E molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG188517|UniProtKB=T1FQ31 T1FQ31 20210928 PTHR19282:SF551 TETRASPANIN TETRASPANIN-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG106891|UniProtKB=T1EE57 T1EE57 20194859 PTHR31322:SF2 E3 UBIQUITIN-PROTEIN LIGASE TM129 E3 UBIQUITIN-PROTEIN LIGASE TM129 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG180727|UniProtKB=T1FG76 T1FG76 20207825 PTHR13008:SF7 MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Apoptosis signaling pathway#P00006>MADD#P00267 HELRO|EnsemblGenome=HelroG185384|UniProtKB=T1FMR0 T1FMR0 20210109 PTHR31885:SF6 GH04784P LYSOPLASMALOGENASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG173156|UniProtKB=T1F6G8 T1F6G8 20204417 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170806|UniProtKB=T1F3G4 T1F3G4 20203363 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG176768|UniProtKB=T1FAW2 T1FAW2 20205961 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG173662|UniProtKB=T1F735 T1F735 20204634 PTHR21180:SF33 ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1 ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG193240|UniProtKB=T1FUS3 T1FUS3 20212569 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183211|UniProtKB=T1FJB4 T1FJB4 20208913 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG183156|UniProtKB=T1FJ82 T1FJ82 20208881 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG62992|UniProtKB=T1FX91 T1FX91 20213439 PTHR43804:SF7 LD18447P LD18447P translation factor#PC00223;translational protein#PC00263;translation release factor#PC00225 HELRO|EnsemblGenome=HelroG74052|UniProtKB=T1G1L7 T1G1L7 20214965 PTHR10856:SF0 CORONIN CORONIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG165139|UniProtKB=T1EWC1 T1EWC1 20200871 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189999|UniProtKB=T1FRK8 T1FRK8 20211455 PTHR45937:SF1 ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1 ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN CG17486 HELRO|EnsemblGenome=HelroG185536|UniProtKB=T1FMY0 T1FMY0 20210179 PTHR13315:SF4 METALLO PHOSPHOESTERASE RELATED METALLOPHOSPHOESTERASE, ISOFORM E biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 metabolite interconversion enzyme#PC00262;esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG159709|UniProtKB=T1EPC1 T1EPC1 20198421 PTHR11941:SF27 ENOYL-COA HYDRATASE-RELATED ETHYLMALONYL-COA DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;hydratase#PC00120;lyase#PC00144 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG81245|UniProtKB=T1G4C1 T1G4C1 20215919 PTHR31792:SF3 VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21 VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21 cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HELRO|EnsemblGenome=HelroG193195|UniProtKB=T1FUQ6 T1FUQ6 20212552 PTHR13484:SF11 FIP1-LIKE 1 PROTEIN FACTOR INTERACTING WITH POLY(A) POLYMERASE 1 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG155932|UniProtKB=T1ELP4 T1ELP4 20197494 PTHR12544:SF52 GLUTAMINASE GLUTAMINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193761|UniProtKB=T1FVC0 T1FVC0 20212766 PTHR24248:SF215 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 84 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG174434|UniProtKB=T1F844 T1F844 20204993 PTHR11818:SF42 BETA/GAMMA CRYSTALLIN SEED LECTIN-LIKE structural protein#PC00211 HELRO|EnsemblGenome=HelroG147328|UniProtKB=T1EJZ4 T1EJZ4 20196894 PTHR46188:SF1 BOLA-LIKE PROTEIN 3 BOLA-LIKE PROTEIN 3 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG76891|UniProtKB=T1G2Q5 T1G2Q5 20215353 PTHR21016:SF1 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of Notch signaling pathway#GO:0045747;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;apoptotic signaling pathway#GO:0097190;regulation of response to stimulus#GO:0048583 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG86847|UniProtKB=T1G6I2 T1G6I2 20216679 PTHR24068:SF135 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 J2 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;transferase activity#GO:0016740;catalytic activity#GO:0003824 response to stimulus#GO:0050896;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to chemical#GO:0042221;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>Ubc6#P01222 HELRO|EnsemblGenome=HelroG76488|UniProtKB=T1G2K6 T1G2K6 20215304 PTHR10997:SF9 IMPORTIN-7, 8, 11 IMPORTIN-9 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;protein localization to organelle#GO:0033365;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 transporter#PC00227 HELRO|EnsemblGenome=HelroG81691|UniProtKB=T1G4H6 T1G4H6 20215974 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG86506|UniProtKB=T1G6D3 T1G6D3 20216630 PTHR10619:SF0 F-ACTIN-CAPPING PROTEIN SUBUNIT BETA F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of actin filament depolymerization#GO:0030834;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex assembly#GO:0031333;regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of actin filament length#GO:0030832;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840 cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell periphery#GO:0071944;cell cortex#GO:0005938;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG107434|UniProtKB=T1EEA5 T1EEA5 20194907 PTHR18884:SF136 SEPTIN SEPTIN-1 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cytokinesis#GO:0000910;intracellular protein localization#GO:0008104;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;cell cycle process#GO:0022402;cellular process#GO:0009987;cell division#GO:0051301;cell cycle#GO:0007049;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HELRO|EnsemblGenome=HelroG162278|UniProtKB=T1ESG0 T1ESG0 20199510 PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 kinetochore assembly#GO:0051382;organelle assembly#GO:0070925;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;kinetochore organization#GO:0051383;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;chromatin organization#GO:0006325;cellular component assembly#GO:0022607 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG173386|UniProtKB=T1F6R5 T1F6R5 20204514 PTHR13168:SF0 ASSOCIATE OF C-MYC AMY-1 C-MYC-BINDING PROTEIN transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 PDGF signaling pathway#P00047>c-Myc#P01172 HELRO|EnsemblGenome=HelroG167628|UniProtKB=T1EZL0 T1EZL0 20202010 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG173624|UniProtKB=T1F723 T1F723 20204622 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;cellular process#GO:0009987;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87291|UniProtKB=T1G6N7 T1G6N7 20216734 PTHR10026:SF51 CYCLIN CYCLIN-T kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription elongation#GO:0032784;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991 kinase activator#PC00138;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG110669|UniProtKB=T1EF41 T1EF41 20195193 PTHR11567:SF25 ACID PHOSPHATASE-RELATED PROTEIN FRA10AC1 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG188533|UniProtKB=T1FQ37 T1FQ37 20210934 PTHR13707:SF23 KETOACID-COENZYME A TRANSFERASE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring sulphur-containing groups#GO:0016782 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG96495|UniProtKB=T1G9C5 T1G9C5 20217672 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG163140|UniProtKB=T1ETP9 T1ETP9 20199949 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182943|UniProtKB=T1FIY4 T1FIY4 20208783 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG192677|UniProtKB=T1FU66 T1FU66 20212362 PTHR31921:SF1 PROTEIN DPCD PROTEIN DPCD protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection assembly#GO:0060491;regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of organelle assembly#GO:1902115 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG177709|UniProtKB=T1FC42 T1FC42 20206391 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG177813|UniProtKB=T1FCB1 T1FCB1 20206460 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG183969|UniProtKB=T1FKD6 T1FKD6 20209285 PTHR13906:SF4 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 6 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 lipid modification#GO:0030258;metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG190655|UniProtKB=T1FS62 T1FS62 20211659 PTHR22692:SF33 MYOSIN VII, XV MYOSIN-VIIA actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG105234|UniProtKB=T1EDR9 T1EDR9 20194721 PTHR14119:SF19 HYDROLASE ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG113093|UniProtKB=T1EFQ2 T1EFQ2 20195404 PTHR10943:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;endopeptidase complex#GO:1905369;cytoplasm#GO:0005737;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;proteasome complex#GO:0000502 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG193513|UniProtKB=T1FV26 T1FV26 20212672 PTHR10408:SF7 STEROL O-ACYLTRANSFERASE DIACYLGLYCEROL O-ACYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 transferase#PC00220;acyltransferase#PC00042 Androgen/estrogene/progesterone biosynthesis#P02727>Cholesterol acyltransferase#P02829 HELRO|EnsemblGenome=HelroG168134|UniProtKB=T1F075 T1F075 20202225 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93112|UniProtKB=T1G8T9 T1G8T9 20217486 PTHR23235:SF60 KRUEPPEL-LIKE TRANSCRIPTION FACTOR STRIPE, ISOFORM D transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG178829|UniProtKB=T1FDT1 T1FDT1 20206980 PTHR10334:SF603 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG188412|UniProtKB=T1FPY8 T1FPY8 20210885 PTHR45859:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA TRANSLATION INITIATION FACTOR EIF2B SUBUNIT BETA translation factor activity#GO:0180051;guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG171459|UniProtKB=T1F4B1 T1F4B1 20203660 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122508|UniProtKB=T1EGU8 T1EGU8 20195798 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG88439|UniProtKB=T1G726 T1G726 20216873 PTHR11054:SF0 6-PHOSPHOGLUCONOLACTONASE 6-PHOSPHOGLUCONOLACTONASE catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;6-phosphogluconolactonase activity#GO:0017057 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;pentose-phosphate shunt, oxidative branch#GO:0009051;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleotide metabolic process#GO:0009117;pentose-phosphate shunt#GO:0006098;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG171153|UniProtKB=T1F3V6 T1F3V6 20203505 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 transcription coregulator activity#GO:0003712;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG80522|UniProtKB=T1G418 T1G418 20215816 PTHR16231:SF4 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG72210|UniProtKB=T1G0X2 T1G0X2 20214720 PTHR18952:SF81 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 13-RELATED catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG112249|UniProtKB=T1EFI1 T1EFI1 20195333 PTHR28658:SF3 TRANSMEMBRANE PROTEIN 180 SOLUTE CARRIER FAMILY 68 MEMBER 1 HELRO|EnsemblGenome=HelroG102643|UniProtKB=T1EDA8 T1EDA8 20194560 PTHR12466:SF8 CDC73 DOMAIN PROTEIN PARAFIBROMIN binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase core enzyme binding#GO:0043175 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG194664|UniProtKB=T1FWA5 T1FWA5 20213101 PTHR21646:SF122 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG89725|UniProtKB=T1G7G6 T1G7G6 20217013 PTHR11467:SF189 HISTONE H1 HISTONE 24 double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490 chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG163523|UniProtKB=T1EU60 T1EU60 20200110 PTHR31283:SF5 EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER L ANTIGEN FAMILY MEMBER 3 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG163335|UniProtKB=T1ETX4 T1ETX4 20200024 PTHR10915:SF1 SYNDECAN SYNDECAN cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169046|UniProtKB=T1F1B3 T1F1B3 20202613 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;snRNA metabolic process#GO:0016073;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nuclear mRNA surveillance#GO:0071028 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG172908|UniProtKB=T1F642 T1F642 20204291 PTHR23349:SF108 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG177587|UniProtKB=T1FBW6 T1FBW6 20206315 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG162746|UniProtKB=T1ET28 T1ET28 20199728 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG102275|UniProtKB=T1ED92 T1ED92 20194544 PTHR43720:SF2 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG68925|UniProtKB=T1FZL8 T1FZL8 20214266 PTHR12651:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 proteasome complex#GO:0000502;nucleus#GO:0005634;cytosol#GO:0005829;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 protein modifying enzyme#PC00260;protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG161972|UniProtKB=T1ES40 T1ES40 20199390 PTHR43020:SF2 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1 MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1 small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity, acting on a tRNA#GO:0140101;transferase activity, transferring sulphur-containing groups#GO:0016782;iron-sulfur cluster binding#GO:0051536;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098 tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mitochondrial RNA modification#GO:1900864;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG168687|UniProtKB=T1F0V1 T1F0V1 20202451 PTHR24388:SF53 ZINC FINGER PROTEIN AT-RICH BINDING PROTEIN-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG166960|UniProtKB=T1EYT2 T1EYT2 20201732 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68811|UniProtKB=T1FZJ8 T1FZJ8 20214246 PTHR11702:SF31 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2 hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG191849|UniProtKB=T1FTC5 T1FTC5 20212072 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG174699|UniProtKB=T1F8D8 T1F8D8 20205087 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;proton channel activity#GO:0015252;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG164056|UniProtKB=T1EUU6 T1EUU6 20200346 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG186069|UniProtKB=T1FNM5 T1FNM5 20210422 PTHR43842:SF2 PROPIONYL-COA CARBOXYLASE BETA CHAIN PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;ligase#PC00142 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163;Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033 HELRO|EnsemblGenome=HelroG163488|UniProtKB=T1EU43 T1EU43 20200093 PTHR23210:SF26 ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG90753|UniProtKB=T1G7V7 T1G7V7 20217154 PTHR10742:SF423 FLAVIN MONOAMINE OXIDASE LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;histone modifying activity#GO:0140993;histone demethylase activity#GO:0032452;demethylase activity#GO:0032451;heterocyclic compound binding#GO:1901363;protein demethylase activity#GO:0140457;chromatin binding#GO:0003682;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidase#PC00175 HELRO|EnsemblGenome=HelroG189892|UniProtKB=T1FRG4 T1FRG4 20211411 PTHR45695:SF9 LEUCOKININ RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170248|UniProtKB=T1F2U0 T1F2U0 20203139 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG192864|UniProtKB=T1FUD5 T1FUD5 20212431 PTHR45857:SF4 FORMIN-LIKE PROTEIN MULTIPLE WING HAIRS, ISOFORM C HELRO|EnsemblGenome=HelroG68450|UniProtKB=T1FZF0 T1FZF0 20214198 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;enzyme regulator activity#GO:0030234;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;heterocyclic compound binding#GO:1901363;molecular function regulator activity#GO:0098772 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG194487|UniProtKB=T1FW42 T1FW42 20213038 PTHR38537:SF8 JITTERBUG, ISOFORM N CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183676|UniProtKB=T1FK09 T1FK09 20209158 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186237|UniProtKB=T1FNU9 T1FNU9 20210496 PTHR33538:SF7 PROTEIN GAMETE EXPRESSED 1 PROTEIN BRAMBLEBERRY HELRO|EnsemblGenome=HelroG116401|UniProtKB=T1EGE5 T1EGE5 20195647 PTHR13140:SF341 MYOSIN UNCONVENTIONAL MYOSIN-IE polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 transport#GO:0006810;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cytoskeleton organization#GO:0007010 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG185325|UniProtKB=T1FMP0 T1FMP0 20210089 PTHR24240:SF232 OPSIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to radiation#GO:0071478;signaling#GO:0023052;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;detection of stimulus#GO:0051606;response to radiation#GO:0009314;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;signal transduction#GO:0007165;biological regulation#GO:0065007 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG188202|UniProtKB=T1FPR9 T1FPR9 20210816 PTHR31431:SF1 NUCLEOPORIN NUP188 HOMOLOG NUCLEOPORIN NUP188 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;intracellular protein transport#GO:0006886;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;nucleocytoplasmic transport#GO:0006913 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634 transporter#PC00227 HELRO|EnsemblGenome=HelroG164395|UniProtKB=T1EVD6 T1EVD6 20200536 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168359|UniProtKB=T1F0G8 T1F0G8 20202318 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188133|UniProtKB=T1FPP0 T1FPP0 20210787 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG190034|UniProtKB=T1FRM0 T1FRM0 20211467 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG164573|UniProtKB=T1EVL2 T1EVL2 20200612 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102800|UniProtKB=T1EDC0 T1EDC0 20194572 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;chloride transmembrane transport#GO:1902476;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG71411|UniProtKB=T1G0L1 T1G0L1 20214609 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;intracellular signal transduction#GO:0035556;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169468|UniProtKB=T1F1Z4 T1F1Z4 20202844 PTHR11266:SF128 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MITOCHONDRIAL INNER MEMBRANE PROTEIN MPV17 channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG183591|UniProtKB=T1FJW3 T1FJW3 20209112 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG185117|UniProtKB=T1FMF0 T1FMF0 20209999 PTHR21277:SF5 TRANSCRIPTIONAL ADAPTER 1 TRANSCRIPTIONAL ADAPTER 1 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;chromatin#GO:0000785;SAGA complex#GO:0000124;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG185800|UniProtKB=T1FNA9 T1FNA9 20210306 PTHR13007:SF19 PRE-MRNA SPLICING FACTOR-RELATED PRE-MRNA-SPLICING FACTOR 18 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607 spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG167499|UniProtKB=T1EZF8 T1EZF8 20201958 PTHR24351:SF230 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;TORC1 signaling#GO:0038202;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;p53 pathway by glucose deprivation#P04397>S6K#P04636;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HELRO|EnsemblGenome=HelroG109032|UniProtKB=T1EEQ1 T1EEQ1 20195053 PTHR13847:SF193 SARCOSINE DEHYDROGENASE-RELATED PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG172823|UniProtKB=T1F5Z2 T1F5Z2 20204241 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG174896|UniProtKB=T1F8L2 T1F8L2 20205161 PTHR23113:SF376 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR C guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG150388|UniProtKB=T1EKF5 T1EKF5 20197055 PTHR11132:SF521 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E2A-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG191034|UniProtKB=T1FSI8 T1FSI8 20211785 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED monoatomic cation channel activity#GO:0005261;monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG165982|UniProtKB=T1EXJ2 T1EXJ2 20201292 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG185478|UniProtKB=T1FMV5 T1FMV5 20210154 PTHR19431:SF0 60S RIBOSOMAL PROTEIN L4 LARGE RIBOSOMAL SUBUNIT PROTEIN UL4 binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG182257|UniProtKB=T1FI02 T1FI02 20208451 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG195072|UniProtKB=T1FWQ4 T1FWQ4 20213249 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG75052|UniProtKB=T1G1Z8 T1G1Z8 20215096 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 bicarbonate transmembrane transporter activity#GO:0015106;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;homeostatic process#GO:0042592;transport#GO:0006810;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG160959|UniProtKB=T1EQW9 T1EQW9 20198969 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90227|UniProtKB=T1G7M5 T1G7M5 20217072 PTHR22977:SF5 COX ASSEMBLY MITOCHONDRIAL PROTEIN COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG156441|UniProtKB=T1ELW7 T1ELW7 20197567 PTHR46493:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 chaperone#PC00072 HELRO|EnsemblGenome=HelroG64159|UniProtKB=T1FXQ4 T1FXQ4 20213602 PTHR24235:SF29 NEUROPEPTIDE Y RECEPTOR GH23382P signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG180596|UniProtKB=T1FG29 T1FG29 20207778 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 kinase#PC00137;metabolite interconversion enzyme#PC00262 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG179939|UniProtKB=T1FF98 T1FF98 20207497 PTHR13843:SF12 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN FUTSCH tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;neuron projection development#GO:0031175;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;dendrite development#GO:0016358;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;cell morphogenesis#GO:0000902;cell development#GO:0048468;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;regulation of protein depolymerization#GO:1901879;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;axon development#GO:0061564;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of microtubule-based process#GO:0032886;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;system development#GO:0048731;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054;cytoskeleton#GO:0005856;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;neuron projection#GO:0043005;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;dendrite#GO:0030425;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;cell body#GO:0044297 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG160886|UniProtKB=T1EQU3 T1EQU3 20198943 PTHR15099:SF2 PROTEIN PM1 TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL cellular component organization#GO:0016043;organelle organization#GO:0006996;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrial membrane organization#GO:0007006;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG162910|UniProtKB=T1ETC3 T1ETC3 20199823 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155584|UniProtKB=T1ELJ2 T1ELJ2 20197442 PTHR10705:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane protein complex#GO:0098796;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG62606|UniProtKB=T1FX27 T1FX27 20213375 PTHR12245:SF11 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN PROTEIN GUSTAVUS ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193107|UniProtKB=T1FUM6 T1FUM6 20212522 PTHR22826:SF211 RHO GUANINE EXCHANGE FACTOR-RELATED LD43457P GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG65623|UniProtKB=T1FYA8 T1FYA8 20213806 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transmission of nerve impulse#GO:0019226;system process#GO:0003008;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of synaptic transmission#GO:0050806;regulation of signaling#GO:0023051;nervous system process#GO:0050877;localization within membrane#GO:0051668;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;localization#GO:0051179;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804 postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transporter complex#GO:1990351;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;cell periphery#GO:0071944;membrane#GO:0016020 voltage-gated ion channel#PC00241;transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG75616|UniProtKB=T1G274 T1G274 20215172 PTHR22998:SF1 SARM1 NAD(+) HYDROLASE SARM1 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;pyridine nucleotide catabolic process#GO:0019364;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;NAD+ metabolic process#GO:0019674;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496 somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;mitochondrion#GO:0005739;cell body#GO:0044297 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171534|UniProtKB=T1F4E0 T1F4E0 20203689 PTHR48169:SF3 DED DOMAIN-CONTAINING PROTEIN CASP8 AND FADD-LIKE APOPTOSIS REGULATOR regulation of extrinsic apoptotic signaling pathway#GO:2001236;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of cell communication#GO:0010648;negative regulation of programmed cell death#GO:0043069;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583 HELRO|EnsemblGenome=HelroG70092|UniProtKB=T1G028 T1G028 20214426 PTHR24418:SF421 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SHARK catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG183181|UniProtKB=T1FJ96 T1FJ96 20208895 PTHR12298:SF8 PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED US5 ASSEMBLY CHAPERONE PDCD2 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG89783|UniProtKB=T1G7H6 T1G7H6 20217023 PTHR11909:SF520 CASEIN KINASE-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263 membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>Casein kinase I#P01242;Wnt signaling pathway#P00057>Casein Kinase 1#P01460 HELRO|EnsemblGenome=HelroG173304|UniProtKB=T1F6N5 T1F6N5 20204484 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;regulation of macromolecule biosynthetic process#GO:0010556;protein localization to nucleus#GO:0034504;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;chromatin organization#GO:0006325;biological regulation#GO:0065007;membrane organization#GO:0061024;negative regulation of biosynthetic process#GO:0009890;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;establishment of localization#GO:0051234;heterochromatin formation#GO:0031507;nuclear migration#GO:0007097;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;organelle localization#GO:0051640;localization#GO:0051179;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;establishment of organelle localization#GO:0051656;cellular localization#GO:0051641 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG194513|UniProtKB=T1FW51 T1FW51 20213047 PTHR12425:SF5 SYNEMBRYN CHAPERONE RIC-8 guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG190724|UniProtKB=T1FS87 T1FS87 20211684 PTHR46170:SF1 GATOR COMPLEX PROTEIN WDR59 GATOR2 COMPLEX PROTEIN WDR59 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;regulation of TORC1 signaling#GO:1903432;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular response to amino acid starvation#GO:0034198;positive regulation of response to stimulus#GO:0048584;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of TORC1 signaling#GO:1904263;response to stress#GO:0006950;response to nutrient levels#GO:0031667 intracellular organelle#GO:0043229;vacuolar membrane#GO:0005774;Seh1-associated complex#GO:0035859;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 HELRO|EnsemblGenome=HelroG190274|UniProtKB=T1FRU7 T1FRU7 20211544 PTHR46569:SF1 E3 UBIQUITIN-PROTEIN LIGASE TRAIP E3 UBIQUITIN-PROTEIN LIGASE TRAIP catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 cellular process#GO:0009987;post-translational protein modification#GO:0043687;replication fork processing#GO:0031297;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA replication#GO:0006260;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;DNA-templated DNA replication#GO:0006261 nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG153284|UniProtKB=T1EL26 T1EL26 20197276 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159637|UniProtKB=T1EP98 T1EP98 20198398 PTHR47577:SF4 THAP DOMAIN-CONTAINING PROTEIN 6 TRANSPOSABLE ELEMENT P TRANSPOSASE-LIKE RNASE H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167073|UniProtKB=T1EYZ2 T1EYZ2 20201792 PTHR14611:SF7 TECTONIC FAMILY MEMBER TECTONIC organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 cilium#GO:0005929;ciliary transition zone#GO:0035869;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG95507|UniProtKB=T1G962 T1G962 20217609 PTHR12040:SF0 ANTI-SILENCING PROTEIN 1 HISTONE CHAPERONE ASF1 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG193172|UniProtKB=T1FUP7 T1FUP7 20212543 PTHR46542:SF1 X-BOX BINDING PROTEIN 1 X-BOX-BINDING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG192685|UniProtKB=T1FU69 T1FU69 20212365 PTHR11188:SF182 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG176369|UniProtKB=T1FAG3 T1FAG3 20205812 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167119|UniProtKB=T1EZ17 T1EZ17 20201817 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG187809|UniProtKB=T1FPE2 T1FPE2 20210689 PTHR21402:SF5 GAMETOCYTE SPECIFIC FACTOR 1-RELATED GAMETOCYTE-SPECIFIC FACTOR 1 HELRO|EnsemblGenome=HelroG187670|UniProtKB=T1FPB8 T1FPB8 20210665 PTHR11134:SF33 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP COMPLEX SUBUNIT BETA molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;transport#GO:0006810 AP-1 adaptor complex#GO:0030121;trans-Golgi network transport vesicle#GO:0030140;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated vesicle#GO:0030136;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular vesicle#GO:0097708;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;clathrin vesicle coat#GO:0030125;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated vesicle membrane#GO:0030665;cytoplasm#GO:0005737;vesicle coat#GO:0030120;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185027|UniProtKB=T1FMA9 T1FMA9 20209958 PTHR42908:SF10 TRANSLATION ELONGATION FACTOR-RELATED EUKARYOTIC TRANSLATION ELONGATION FACTOR 2 translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;translation elongation factor activity#GO:0003746;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translational elongation#GO:0006414;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cytosol#GO:0005829;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG180450|UniProtKB=T1FFX8 T1FFX8 20207727 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG194674|UniProtKB=T1FWA9 T1FWA9 20213105 PTHR47385:SF14 CALPONIN TRANSGELIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185511|UniProtKB=T1FMX0 T1FMX0 20210169 PTHR47979:SF137 DRAB11-RELATED RAB11 hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;exocytosis#GO:0006887;secretion by cell#GO:0032940;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG166711|UniProtKB=T1EYE7 T1EYE7 20201597 PTHR46830:SF1 TRANSFERASE, PUTATIVE-RELATED ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220 HELRO|EnsemblGenome=HelroG178453|UniProtKB=T1FD67 T1FD67 20206766 PTHR11819:SF150 SOLUTE CARRIER FAMILY 5 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M-RELATED symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG115438|UniProtKB=T1EG81 T1EG81 20195583 PTHR16160:SF13 FERMITIN 2-RELATED FERMITIN 2-RELATED protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;cell-substrate junction#GO:0030055 HELRO|EnsemblGenome=HelroG170319|UniProtKB=T1F2X2 T1F2X2 20203171 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG81815|UniProtKB=T1G4J0 T1G4J0 20215988 PTHR15362:SF4 PHOSPHATIDYLINOSITOL SYNTHASE CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220 HELRO|EnsemblGenome=HelroG89495|UniProtKB=T1G7D5 T1G7D5 20216982 PTHR12027:SF70 WNT RELATED PROTEIN WNT-16 signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell fate commitment#GO:0045165;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HELRO|EnsemblGenome=HelroG176328|UniProtKB=T1FAE3 T1FAE3 20205792 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HELRO|EnsemblGenome=HelroG167218|UniProtKB=T1EZ56 T1EZ56 20201856 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG190497|UniProtKB=T1FS16 T1FS16 20211613 PTHR12960:SF0 GLE-1-RELATED MRNA EXPORT FACTOR GLE1 binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;lipid binding#GO:0008289;protein binding#GO:0005515;phospholipid binding#GO:0005543;alcohol binding#GO:0043178;translation initiation factor binding#GO:0031369 nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169 organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translation factor#PC00223 HELRO|EnsemblGenome=HelroG75092|UniProtKB=T1G203 T1G203 20215101 PTHR12141:SF1 ARFAPTIN-RELATED PRKCA-BINDING PROTEIN molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 localization#GO:0051179;synapse organization#GO:0050808;localization within membrane#GO:0051668;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;postsynapse organization#GO:0099173;regulation of supramolecular fiber organization#GO:1902903;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;regulation of actin nucleation#GO:0051125;intracellular transport#GO:0046907;regulation of actin filament-based process#GO:0032970;transport#GO:0006810;positive regulation of endocytosis#GO:0045807;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;cellular localization#GO:0051641;protein transport#GO:0015031;receptor clustering#GO:0043113;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;neuron projection organization#GO:0106027;cell projection organization#GO:0030030;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;intracellular protein transport#GO:0006886;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of biological process#GO:0048518;dendritic spine organization#GO:0097061;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;establishment of protein localization#GO:0045184;cellular process#GO:0009987 organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular vesicle#GO:0097708;postsynapse#GO:0098794;cell junction#GO:0030054;trans-Golgi network membrane#GO:0032588;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;postsynaptic density#GO:0014069;asymmetric synapse#GO:0032279;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;postsynaptic specialization#GO:0099572;transport vesicle#GO:0030133;neuron to neuron synapse#GO:0098984;endomembrane system#GO:0012505;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 vesicle coat protein#PC00235 Ionotropic glutamate receptor pathway#P00037>PICK#P01012 HELRO|EnsemblGenome=HelroG92323|UniProtKB=T1G8E4 T1G8E4 20217341 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG77785|UniProtKB=T1G339 T1G339 20215487 PTHR10582:SF41 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN INACTIVE calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG85482|UniProtKB=T1G5X7 T1G5X7 20216474 PTHR24055:SF79 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 15 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 PDGF signaling pathway#P00047>ERK#P01143;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Interleukin signaling pathway#P00036>ERK#P00965;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Parkinson disease#P00049>ERK#P01211;EGF receptor signaling pathway#P00018>ERK1-2#P00543 HELRO|EnsemblGenome=HelroG194220|UniProtKB=T1FVT8 T1FVT8 20212934 PTHR11139:SF119 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE SMG1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 negative regulation of catabolic process#GO:0009895;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;negative regulation of autophagy#GO:0010507;regulation of macroautophagy#GO:0016241;regulation of catabolic process#GO:0009894;signal transduction#GO:0007165;negative regulation of macroautophagy#GO:0016242;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;TOR signaling#GO:0031929 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;TOR complex#GO:0038201;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>PI3K#P00557 HELRO|EnsemblGenome=HelroG73094|UniProtKB=T1G198 T1G198 20214846 PTHR11827:SF100 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 9 symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride transmembrane transporter activity#GO:0015108;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG155661|UniProtKB=T1ELJ9 T1ELJ9 20197449 PTHR11579:SF0 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;O-methyltransferase activity#GO:0008171;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG190886|UniProtKB=T1FSE1 T1FSE1 20211738 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 32 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TLR#P01346 HELRO|EnsemblGenome=HelroG178840|UniProtKB=T1FDT5 T1FDT5 20206984 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG76345|UniProtKB=T1G2I5 T1G2I5 20215283 PTHR23073:SF12 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 8 isomerase activity#GO:0016853;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;proteasome complex#GO:0000502 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG176352|UniProtKB=T1FAF3 T1FAF3 20205802 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178145|UniProtKB=T1FCU1 T1FCU1 20206640 PTHR31105:SF42 EXTRA-LARGE G-PROTEIN-LIKE G-LIKE PROTEIN, PUTATIVE (DUF3133)-RELATED HELRO|EnsemblGenome=HelroG173705|UniProtKB=T1F751 T1F751 20204650 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189957|UniProtKB=T1FRJ1 T1FRJ1 20211438 PTHR11731:SF202 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG116629|UniProtKB=T1EGG7 T1EGG7 20195669 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FI18312P1 phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG121825|UniProtKB=T1EGS8 T1EGS8 20195778 PTHR18952:SF81 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 13-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG136402|UniProtKB=T1EID9 T1EID9 20196339 PTHR24247:SF265 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR DM1 G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;acetylcholine receptor activity#GO:0015464;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;dendritic tree#GO:0097447;cell junction#GO:0030054 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG113705|UniProtKB=T1EFV4 T1EFV4 20195456 PTHR23284:SF0 PROLACTIN REGULATORY ELEMENT BINDING PROTEIN GUANINE NUCLEOTIDE-EXCHANGE FACTOR SEC12 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;membrane organization#GO:0061024;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;COPII-coated vesicle budding#GO:0090114;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG168799|UniProtKB=T1F0Z5 T1F0Z5 20202495 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium ion transmembrane transporter activity#GO:0015079;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG106052|UniProtKB=T1EDZ7 T1EDZ7 20194799 PTHR10687:SF61 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;vesicle membrane#GO:0012506;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG165049|UniProtKB=T1EW72 T1EW72 20200822 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187533|UniProtKB=T1FPA4 T1FPA4 20210651 PTHR17583:SF0 PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein localization to vacuole#GO:0072665;cellular localization#GO:0051641;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;protein localization to organelle#GO:0033365;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666;catabolic process#GO:0009056;late endosome to vacuole transport#GO:0045324;intracellular transport#GO:0046907;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;pexophagy#GO:0000425;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein targeting to vacuole#GO:0006623;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;macroautophagy#GO:0016236 transferase complex, transferring phosphorus-containing groups#GO:0061695;endosome#GO:0005768;phosphatidylinositol 3-kinase complex, class III#GO:0035032;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle membrane contact site#GO:0044232;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG194043|UniProtKB=T1FVL8 T1FVL8 20212864 PTHR12243:SF60 MADF DOMAIN TRANSCRIPTION FACTOR MADF DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG179436|UniProtKB=T1FEP7 T1FEP7 20207296 PTHR11801:SF70 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell surface receptor signaling pathway via JAK-STAT#GO:0007259;cell surface receptor signaling pathway#GO:0007166;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of biosynthetic process#GO:0009889;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cell surface receptor signaling pathway via STAT#GO:0097696;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173 HELRO|EnsemblGenome=HelroG115999|UniProtKB=T1EGC5 T1EGC5 20195627 PTHR22727:SF15 PROTEIN CBG13728 MRH DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG181811|UniProtKB=T1FHD0 T1FHD0 20208229 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG86858|UniProtKB=T1G6I4 T1G6I4 20216681 PTHR10913:SF45 FOLLISTATIN-RELATED AGRIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG181954|UniProtKB=T1FHI3 T1FHI3 20208282 PTHR13720:SF33 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG126004|UniProtKB=T1EH81 T1EH81 20195931 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG131704|UniProtKB=T1EHW3 T1EHW3 20196163 PTHR12560:SF0 LONGEVITY ASSURANCE FACTOR 1 LAG1 LD18904P acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 ceramide metabolic process#GO:0006672;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184634|UniProtKB=T1FLM7 T1FLM7 20209726 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182842|UniProtKB=T1FIU6 T1FIU6 20208745 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG126000|UniProtKB=T1EH80 T1EH80 20195930 PTHR45669:SF18 GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG108613|UniProtKB=T1EEK9 T1EEK9 20195011 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE transmembrane transport#GO:0055085;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG185574|UniProtKB=T1FMZ7 T1FMZ7 20210196 PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG106435|UniProtKB=T1EE26 T1EE26 20194828 PTHR24031:SF307 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX1 tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG66166|UniProtKB=T1FYH8 T1FYH8 20213876 PTHR11679:SF91 VESICLE PROTEIN SORTING-ASSOCIATED PROTEIN ROP protein binding#GO:0005515;syntaxin binding#GO:0019905;SNARE binding#GO:0000149;binding#GO:0005488 organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;anterograde trans-synaptic signaling#GO:0098916;intracellular transport#GO:0046907;calcium-ion regulated exocytosis#GO:0017156;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;vesicle localization#GO:0051648;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular localization#GO:0051641;protein transport#GO:0015031;secretion by cell#GO:0032940;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;signaling#GO:0023052;export from cell#GO:0140352;regulated exocytosis#GO:0045055;intracellular protein transport#GO:0006886;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;synaptic vesicle exocytosis#GO:0016079;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG84352|UniProtKB=T1G5H7 T1G5H7 20216324 PTHR10302:SF0 SINGLE-STRANDED DNA-BINDING PROTEIN SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;DNA binding#GO:0003677;enzyme regulator activity#GO:0030234;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;regulation of mitochondrion organization#GO:0010821;regulation of organelle organization#GO:0033043;regulation of DNA-templated DNA replication#GO:0090329;regulation of DNA metabolic process#GO:0051052;DNA replication#GO:0006260;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of cellular component organization#GO:0051130;regulation of DNA replication#GO:0006275;positive regulation of metabolic process#GO:0009893;positive regulation of organelle organization#GO:0010638;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA replication#GO:0045740;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;mitochondrial nucleoid#GO:0042645;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoid#GO:0009295;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG161296|UniProtKB=T1ERB0 T1ERB0 20199110 PTHR12461:SF106 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5 histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;protein demethylase activity#GO:0140457;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;chromatin binding#GO:0003682;binding#GO:0005488;histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161507|UniProtKB=T1ERK5 T1ERK5 20199205 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;binding#GO:0005488 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG90986|UniProtKB=T1G7Y3 T1G7Y3 20217180 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG103045|UniProtKB=T1EDD9 T1EDD9 20194591 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING IP01257P-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG188183|UniProtKB=T1FPR1 T1FPR1 20210808 PTHR13318:SF190 PARTNER OF PAIRED, ISOFORM B-RELATED PARTNER OF PAIRED, ISOFORM B SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG188449|UniProtKB=T1FQ00 T1FQ00 20210897 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG193451|UniProtKB=T1FV00 T1FV00 20212646 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG182030|UniProtKB=T1FHM0 T1FHM0 20208319 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG158933|UniProtKB=T1ENF2 T1ENF2 20198102 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185489|UniProtKB=T1FMV9 T1FMV9 20210158 PTHR48419:SF1 SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN SULFOTRANSFERASE FAMILY PROTEIN HELRO|EnsemblGenome=HelroG104089|UniProtKB=T1EDJ6 T1EDJ6 20194648 PTHR43550:SF3 3-KETODIHYDROSPHINGOSINE REDUCTASE 3-KETODIHYDROSPHINGOSINE REDUCTASE oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG186114|UniProtKB=T1FNN9 T1FNN9 20210436 PTHR23382:SF34 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;oxoacid metabolic process#GO:0043436;nucleobase-containing compound metabolic process#GO:0006139;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 dehydrogenase#PC00092 TCA cycle#P00051>Malate Dehydrogenase#P01270 HELRO|EnsemblGenome=HelroG144444|UniProtKB=T1EJE8 T1EJE8 20196698 PTHR11040:SF223 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG175436|UniProtKB=T1F994 T1F994 20205393 PTHR31186:SF1 MODULATOR OF SMOOTHENED PROTEIN MODULATOR OF SMOOTHENED PROTEIN negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648 cilium#GO:0005929;intracellular organelle#GO:0043229;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;ciliary membrane#GO:0060170;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG155780|UniProtKB=T1ELM3 T1ELM3 20197473 PTHR24418:SF162 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG76996|UniProtKB=T1G2S2 T1G2S2 20215370 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION HDC11342-RELATED regulation of organelle assembly#GO:1902115;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of mitotic spindle assembly#GO:1901673;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;regulation of spindle organization#GO:0090224;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of microtubule-based process#GO:0032886;regulation of mitotic spindle organization#GO:0060236;regulation of spindle assembly#GO:0090169 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG187946|UniProtKB=T1FPH8 T1FPH8 20210725 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG99990|UniProtKB=T1G9W0 T1G9W0 20217856 PTHR43778:SF4 PYRUVATE CARBOXYLASE PYRUVATE CARBOXYLASE, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874 small molecule biosynthetic process#GO:0044283;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;glucose metabolic process#GO:0006006;cellular process#GO:0009987;gluconeogenesis#GO:0006094;hexose biosynthetic process#GO:0019319;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate biosynthetic process#GO:0016051;monosaccharide biosynthetic process#GO:0046364;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ligase#PC00142;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Pyruvate Carboxylase#P03140 HELRO|EnsemblGenome=HelroG168829|UniProtKB=T1F106 T1F106 20202506 PTHR11558:SF11 SPERMIDINE/SPERMINE SYNTHASE SPERMIDINE SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 polyamine biosynthetic process#GO:0006596;biosynthetic process#GO:0009058;biogenic amine metabolic process#GO:0006576;amine metabolic process#GO:0009308;metabolic process#GO:0008152;cellular process#GO:0009987;polyamine metabolic process#GO:0006595 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG163447|UniProtKB=T1EU23 T1EU23 20200073 PTHR21694:SF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 HELRO|EnsemblGenome=HelroG181103|UniProtKB=T1FGL9 T1FGL9 20207968 PTHR23179:SF3 T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED RHO GTPASE-ACTIVATING PROTEIN 20 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG159400|UniProtKB=T1EP03 T1EP03 20198303 PTHR34639:SF1 PROTEIN FLATTOP PROTEIN FLATTOP cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG89686|UniProtKB=T1G7F7 T1G7F7 20217004 PTHR11792:SF17 ARRESTIN KURTZ ARRESTIN binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515 nervous system process#GO:0050877;regulation of signaling#GO:0023051;sensory perception#GO:0007600;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;localization#GO:0051179;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of G protein-coupled receptor signaling pathway#GO:0008277;transport#GO:0006810;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;system process#GO:0003008;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;receptor internalization#GO:0031623;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;vesicle-mediated transport#GO:0016192 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>beta-arrestin#P00880;Wnt signaling pathway#P00057>beta-arrestin#P01456;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>beta-arrestin#P00723 HELRO|EnsemblGenome=HelroG162328|UniProtKB=T1ESI5 T1ESI5 20199535 PTHR10217:SF642 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG159284|UniProtKB=T1ENU2 T1ENU2 20198242 PTHR16216:SF11 DYNEIN ASSEMBLY FACTOR 5, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 5 protein binding#GO:0005515;binding#GO:0005488 cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;inner dynein arm assembly#GO:0036159;organelle assembly#GO:0070925;cell projection organization#GO:0030030;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG69993|UniProtKB=T1G012 T1G012 20214410 PTHR21231:SF8 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 1 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 small GTPase#PC00208;protein-binding activity modulator#PC00095;G-protein#PC00020 HELRO|EnsemblGenome=HelroG107164|UniProtKB=T1EE82 T1EE82 20194884 PTHR10574:SF375 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-1 neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;axon development#GO:0061564;axon guidance#GO:0007411;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cell migration#GO:0016477;tissue development#GO:0009888;extracellular matrix assembly#GO:0085029;external encapsulating structure organization#GO:0045229;system development#GO:0048731;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;cell-substrate adhesion#GO:0031589;cell motility#GO:0048870;plasma membrane bounded cell projection morphogenesis#GO:0120039;substrate adhesion-dependent cell spreading#GO:0034446;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular component assembly#GO:0022607;generation of neurons#GO:0048699;cell adhesion#GO:0007155;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG192824|UniProtKB=T1FUC2 T1FUC2 20212418 PTHR48153:SF5 UFM1-SPECIFIC PROTEASE 2 UFM1-SPECIFIC PROTEASE 2 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG181634|UniProtKB=T1FH70 T1FH70 20208169 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG187057|UniProtKB=T1FP64 T1FP64 20210611 PTHR13000:SF0 NUCLEOPORIN P54 NUCLEOPORIN P54 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;nucleocytoplasmic transport#GO:0006913;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;cellular localization#GO:0051641;nuclear pore organization#GO:0006999;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;organelle organization#GO:0006996;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;nucleus organization#GO:0006997;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 transporter#PC00227 HELRO|EnsemblGenome=HelroG69008|UniProtKB=T1FZN3 T1FZN3 20214281 PTHR11205:SF19 RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN US7M mRNA binding#GO:0003729;binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;structural molecule activity#GO:0005198;RNA binding#GO:0003723 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG115427|UniProtKB=T1EG80 T1EG80 20195582 PTHR43084:SF1 PERSULFIDE DIOXYGENASE ETHE1 PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG92182|UniProtKB=T1G8C7 T1G8C7 20217324 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG100094|UniProtKB=T1ECY6 T1ECY6 20194438 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG184870|UniProtKB=T1FM38 T1FM38 20209887 PTHR10210:SF45 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176131|UniProtKB=T1FA67 T1FA67 20205716 PTHR24180:SF60 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED FORK-HEAD DOMAIN-CONTAINING PROTEIN kinase inhibitor#PC00139;kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG173103|UniProtKB=T1F6C7 T1F6C7 20204376 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191166|UniProtKB=T1FSP3 T1FSP3 20211840 PTHR13173:SF10 WW DOMAIN BINDING PROTEIN 4 WW DOMAIN-BINDING PROTEIN 4 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG157371|UniProtKB=T1EMA4 T1EMA4 20197704 PTHR24351:SF249 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG74787|UniProtKB=T1G1V5 T1G1V5 20215053 PTHR19871:SF14 BETA TRANSDUCIN-RELATED PROTEIN NACHT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169169|UniProtKB=T1F1I7 T1F1I7 20202687 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181119|UniProtKB=T1FGM7 T1FGM7 20207976 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187003|UniProtKB=T1FP54 T1FP54 20210601 PTHR10257:SF5 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WIDERBORST, ISOFORM H enzyme activator activity#GO:0008047;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;organelle organization#GO:0006996;cellular process#GO:0009987;sister chromatid cohesion#GO:0007062;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG152723|UniProtKB=T1EKW3 T1EKW3 20197213 PTHR12490:SF6 GSK3B-INTERACTING PROTEIN GEO05133P1-RELATED kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;protein kinase A binding#GO:0051018;binding#GO:0005488 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG165578|UniProtKB=T1EX11 T1EX11 20201111 PTHR10917:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on RNA#GO:0140098 RNA polymerase III complex#GO:0005666;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG182447|UniProtKB=T1FI75 T1FI75 20208524 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG174084|UniProtKB=T1F7L0 T1F7L0 20204809 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG184906|UniProtKB=T1FM57 T1FM57 20209906 PTHR13247:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11 MITOCHONDRIAL FISSION 1 PROTEIN lipid binding#GO:0008289;binding#GO:0005488 mitochondrion organization#GO:0007005;mitochondrial fission#GO:0000266;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;organelle fission#GO:0048285;cellular component organization or biogenesis#GO:0071840;peroxisome organization#GO:0007031 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial envelope#GO:0005740;microbody#GO:0042579;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG91264|UniProtKB=T1G821 T1G821 20217218 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG67981|UniProtKB=T1FZ89 T1FZ89 20214137 PTHR45701:SF3 SYNAPTOBREVIN FAMILY MEMBER SYNAPTOBREVIN SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein binding#GO:0005515;syntaxin binding#GO:0019905;SNAP receptor activity#GO:0005484 organelle membrane fusion#GO:0090174;vesicle fusion#GO:0006906;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;cellular component organization#GO:0016043;membrane fusion#GO:0061025;organelle organization#GO:0006996;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;transport#GO:0006810 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 membrane traffic protein#PC00150 Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986 HELRO|EnsemblGenome=HelroG166962|UniProtKB=T1EYT4 T1EYT4 20201734 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180244|UniProtKB=T1FFM2 T1FFM2 20207621 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG155763|UniProtKB=T1ELM1 T1ELM1 20197471 PTHR22761:SF10 CHARGED MULTIVESICULAR BODY PROTEIN BCDNA.GH08385-RELATED late endosome to vacuole transport#GO:0045324;membrane assembly#GO:0071709;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;nuclear envelope organization#GO:0006998;endosomal transport#GO:0016197;nucleus organization#GO:0006997;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907 nucleus#GO:0005634;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;nuclear envelope#GO:0005635;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;cytoplasmic side of plasma membrane#GO:0009898;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;side of membrane#GO:0098552 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG193825|UniProtKB=T1FVE3 T1FVE3 20212789 PTHR23509:SF50 PA-PL1 PHOSPHOLIPASE FAMILY LD21067P catalytic activity#GO:0003824;lipase activity#GO:0016298;glycerophospholipase activity#GO:0004620;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 metabolite interconversion enzyme#PC00262;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG156740|UniProtKB=T1EM05 T1EM05 20197605 PTHR23235:SF183 KRUEPPEL-LIKE TRANSCRIPTION FACTOR DENDRITIC ARBOR REDUCTION PROTEIN 1 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG188358|UniProtKB=T1FPX1 T1FPX1 20210868 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG85927|UniProtKB=T1G646 T1G646 20216543 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159119|UniProtKB=T1ENM3 T1ENM3 20198173 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179818|UniProtKB=T1FF67 T1FF67 20207466 PTHR31534:SF3 ATAXIN 7, ISOFORM A ATAXIN-7 HELRO|EnsemblGenome=HelroG102569|UniProtKB=T1EDA4 T1EDA4 20194556 PTHR12268:SF14 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROPHIN-1 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83673|UniProtKB=T1G589 T1G589 20216236 PTHR10159:SF540 DUAL SPECIFICITY PROTEIN PHOSPHATASE RHODANESE DOMAIN-CONTAINING DUAL SPECIFICITY PROTEIN PHOSPHATASE-RELATED protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG171104|UniProtKB=T1F3T3 T1F3T3 20203482 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190054|UniProtKB=T1FRM5 T1FRM5 20211472 PTHR24373:SF417 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LAMBIK signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75495|UniProtKB=T1G259 T1G259 20215157 PTHR18860:SF184 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA scaffold/adaptor protein#PC00226 PI3 kinase pathway#P00048>14-3-3#P01206;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624;Parkinson disease#P00049>14-3-3#P01238 HELRO|EnsemblGenome=HelroG189206|UniProtKB=T1FQS6 T1FQS6 20211173 PTHR15907:SF223 DUF614 FAMILY PROTEIN-RELATED CELL NUMBER REGULATOR 10 HELRO|EnsemblGenome=HelroG86160|UniProtKB=T1G678 T1G678 20216575 PTHR10845:SF259 REGULATOR OF G PROTEIN SIGNALING RGS DOMAIN-CONTAINING PROTEIN-RELATED enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG108015|UniProtKB=T1EEE7 T1EEE7 20194949 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG109416|UniProtKB=T1EET6 T1EET6 20195088 PTHR22780:SF4 ADAPTIN, ALPHA/GAMMA/EPSILON AP-2 COMPLEX SUBUNIT ALPHA molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898 clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane coat#GO:0030117;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;clathrin vesicle coat#GO:0030125;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;vesicle coat#GO:0030120;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;coated membrane#GO:0048475;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 Huntington disease#P00029>alpha-Adaptin#P00782 HELRO|EnsemblGenome=HelroG65077|UniProtKB=T1FY29 T1FY29 20213727 PTHR11092:SF0 SUGAR NUCLEOTIDE EPIMERASE RELATED EPIMERASE FAMILY PROTEIN SDR39U1 epimerase/racemase#PC00096 HELRO|EnsemblGenome=HelroG67464|UniProtKB=T1FZ13 T1FZ13 20214061 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG80436|UniProtKB=T1G407 T1G407 20215805 PTHR11177:SF317 CHITINASE GH18 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;chitinase activity#GO:0004568;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;amino sugar metabolic process#GO:0006040;chitin metabolic process#GO:0006030;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;chitin catabolic process#GO:0006032;amino sugar catabolic process#GO:0046348;aminoglycan catabolic process#GO:0006026 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG111023|UniProtKB=T1EF72 T1EF72 20195224 PTHR10502:SF247 ANNEXIN ANNEXIN B10 ion binding#GO:0043167;binding#GO:0005488;phospholipid binding#GO:0005543;small molecule binding#GO:0036094;anion binding#GO:0043168;lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786 vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG176887|UniProtKB=T1FB07 T1FB07 20206006 PTHR47570:SF1 ZINC ION BINDING PROTEIN ZINC ION BINDING PROTEIN HELRO|EnsemblGenome=HelroG63609|UniProtKB=T1FXI1 T1FXI1 20213529 PTHR45829:SF4 MITOCHONDRIAL CARRIER PROTEIN RIM2 MITOCHONDRIAL CARRIER PROTEIN RIM2 organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HELRO|EnsemblGenome=HelroG167698|UniProtKB=T1EZP4 T1EZP4 20202044 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183309|UniProtKB=T1FJG0 T1FJG0 20208959 PTHR32141:SF195 FAMILY NOT NAMED F-BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167113|UniProtKB=T1EZ13 T1EZ13 20201813 PTHR46679:SF1 FAMILY NOT NAMED GLUTAREDOXIN-2, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG186406|UniProtKB=T1FNZ2 T1FNZ2 20210539 PTHR21229:SF86 LUNG SEVEN TRANSMEMBRANE RECEPTOR GH17801P vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG76777|UniProtKB=T1G2P4 T1G2P4 20215342 PTHR11347:SF198 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE, ISOFORM I phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG177465|UniProtKB=T1FBQ7 T1FBQ7 20206256 PTHR46927:SF4 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG152908|UniProtKB=T1EKY0 T1EKY0 20197230 PTHR21146:SF3 MEF2B PROTEIN BLOC-1-RELATED COMPLEX SUBUNIT 8 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 p38 MAPK pathway#P05918>MEF#P06023 HELRO|EnsemblGenome=HelroG182905|UniProtKB=T1FIW9 T1FIW9 20208768 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171298|UniProtKB=T1F419 T1F419 20203568 PTHR15698:SF4 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG111666|UniProtKB=T1EFD5 T1EFD5 20195287 PTHR11947:SF3 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG81548|UniProtKB=T1G4F6 T1G4F6 20215954 PTHR12937:SF0 VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 protein metabolic process#GO:0019538;localization#GO:0051179;protein localization to vacuole#GO:0072665;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;macromolecule localization#GO:0033036;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;cellular localization#GO:0051641;protein transport#GO:0015031;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;endosomal transport#GO:0016197;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;ESCRT I complex#GO:0000813;membrane#GO:0016020;cytosol#GO:0005829;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185009|UniProtKB=T1FM99 T1FM99 20209948 PTHR43160:SF3 ACONITATE HYDRATASE B ACONITATE HYDRATASE, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;iron-sulfur cluster binding#GO:0051536;hydro-lyase activity#GO:0016836;small molecule binding#GO:0036094;catalytic activity#GO:0003824;binding#GO:0005488 tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 mitochondrion#GO:0005739;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 lyase#PC00144;hydratase#PC00120 TCA cycle#P00051>Aconitase#P01268 HELRO|EnsemblGenome=HelroG170488|UniProtKB=T1F343 T1F343 20203242 PTHR13140:SF550 MYOSIN MYOSIN-IIIB ISOFORM X1 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;membrane#GO:0016020 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG172177|UniProtKB=T1F545 T1F545 20203944 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746 HELRO|EnsemblGenome=HelroG184203|UniProtKB=T1FKR5 T1FKR5 20209414 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG79315|UniProtKB=T1G3M6 T1G3M6 20215674 PTHR10223:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488;protein binding#GO:0005515 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 proteasome complex#GO:0000502;nucleus#GO:0005634;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protease#PC00190 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG189210|UniProtKB=T1FQS8 T1FQS8 20211175 PTHR46830:SF2 TRANSFERASE, PUTATIVE-RELATED ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220 HELRO|EnsemblGenome=HelroG178030|UniProtKB=T1FCM8 T1FCM8 20206577 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG87671|UniProtKB=T1G6U0 T1G6U0 20216787 PTHR46257:SF3 TYROSINE-PROTEIN PHOSPHATASE CORKSCREW TYROSINE-PROTEIN PHOSPHATASE CORKSCREW binding#GO:0005488;protein binding#GO:0005515;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 cellular developmental process#GO:0048869;mitotic cell cycle#GO:0000278;cell differentiation#GO:0030154;cellular process#GO:0009987;developmental process#GO:0032502;cell cycle#GO:0007049 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Interferon-gamma signaling pathway#P00035>PTP#P00960;FGF signaling pathway#P00021>SHP2#P00647 HELRO|EnsemblGenome=HelroG176070|UniProtKB=T1FA38 T1FA38 20205687 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194103|UniProtKB=T1FVP1 T1FVP1 20212887 PTHR10924:SF27 MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED SOLUTE CARRIER FAMILY 49 MEMBER 4 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG187144|UniProtKB=T1FP72 T1FP72 20210619 PTHR10218:SF302 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165 G-protein#PC00020;heterotrimeric G-protein#PC00117 HELRO|EnsemblGenome=HelroG159187|UniProtKB=T1ENQ2 T1ENQ2 20198202 PTHR10920:SF13 RIBOSOMAL RNA METHYLTRANSFERASE PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3 catalytic activity, acting on a rRNA#GO:0140102;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA (guanine) methyltransferase activity#GO:0016435;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;rRNA modification#GO:0000154;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;methylation#GO:0032259;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;rRNA processing#GO:0006364;macromolecule biosynthetic process#GO:0009059;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG184368|UniProtKB=T1FL25 T1FL25 20209524 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96652|UniProtKB=T1G9D0 T1G9D0 20217677 PTHR12957:SF2 DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED INTEGRATOR COMPLEX SUBUNIT 6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;integrator complex#GO:0032039;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG144985|UniProtKB=T1EJH8 T1EJH8 20196728 PTHR11467:SF189 HISTONE H1 HISTONE 24 chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677 negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG179960|UniProtKB=T1FFA5 T1FFA5 20207504 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77993|UniProtKB=T1G362 T1G362 20215510 PTHR11920:SF499 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653 nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate biosynthetic process#GO:0046390;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG169093|UniProtKB=T1F1D8 T1F1D8 20202638 PTHR11799:SF12 PARAOXONASE PARAOXONASE catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193655|UniProtKB=T1FV84 T1FV84 20212730 PTHR31002:SF34 SERIPAUPERIN CELL WALL PROTEIN CWP1-RELATED HELRO|EnsemblGenome=HelroG185019|UniProtKB=T1FMA4 T1FMA4 20209953 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164168|UniProtKB=T1EV12 T1EV12 20200412 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192317|UniProtKB=T1FTT8 T1FTT8 20212235 PTHR21345:SF3 SPIRE PROTEIN SPIRE cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cytokinetic process#GO:0032506;nuclear division#GO:0000280;cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;spindle localization#GO:0051653;cellular localization#GO:0051641;cell cycle process#GO:0022402;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;establishment of organelle localization#GO:0051656;gamete generation#GO:0007276;membrane invagination#GO:0010324;Golgi vesicle transport#GO:0048193;meiotic cell cycle#GO:0051321;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192;sexual reproduction#GO:0019953;actin filament-based process#GO:0030029;organelle localization#GO:0051640;supramolecular fiber organization#GO:0097435;multicellular organismal reproductive process#GO:0048609;localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;cell division#GO:0051301;cell cycle#GO:0007049;reproductive process#GO:0022414;actin cytoskeleton organization#GO:0030036;transport#GO:0006810;intracellular transport#GO:0046907;actin filament organization#GO:0007015;meiotic nuclear division#GO:0140013;establishment of localization#GO:0051234;establishment of spindle localization#GO:0051293;membrane organization#GO:0061024 cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090;vesicle#GO:0031982;cell cortex#GO:0005938;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG189241|UniProtKB=T1FQU8 T1FQU8 20211195 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG106175|UniProtKB=T1EE07 T1EE07 20194809 PTHR24055:SF615 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;FGF signaling pathway#P00021>p38#P00644;TGF-beta signaling pathway#P00052>P38#P01275;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>p38#P00562;Ras Pathway#P04393>p38#P04558;Oxidative stress response#P00046>p38#P01135;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Parkinson disease#P00049>p38 MAPK#P01212 HELRO|EnsemblGenome=HelroG185801|UniProtKB=T1FNB0 T1FNB0 20210307 PTHR31965:SF1 TRANSMEMBRANE PROTEIN 42 TRANSMEMBRANE PROTEIN 42 HELRO|EnsemblGenome=HelroG105398|UniProtKB=T1EDU5 T1EDU5 20194747 PTHR10501:SF13 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A snRNA binding#GO:0017069;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;U1 snRNP#GO:0005685;intracellular membrane-bounded organelle#GO:0043231;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 mRNA splicing#P00058>U2#P01478;mRNA splicing#P00058>U1#P01479 HELRO|EnsemblGenome=HelroG72643|UniProtKB=T1G132 T1G132 20214780 PTHR20855:SF15 ADIPOR/PROGESTIN RECEPTOR-RELATED PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 macromolecule localization#GO:0033036;protein localization to Golgi apparatus#GO:0034067;intracellular protein localization#GO:0008104;localization#GO:0051179;protein localization to organelle#GO:0033365 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG122299|UniProtKB=T1EGU4 T1EGU4 20195794 PTHR24229:SF114 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;binding#GO:0005488;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG146503|UniProtKB=T1EJS7 T1EJS7 20196827 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096 regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HELRO|EnsemblGenome=HelroG69928|UniProtKB=T1G000 T1G000 20214398 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG111877|UniProtKB=T1EFF3 T1EFF3 20195305 PTHR16525:SF1 PROTEIN C12ORF4 LD27564P cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG123773|UniProtKB=T1EGY9 T1EGY9 20195839 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG193805|UniProtKB=T1FVD5 T1FVD5 20212781 PTHR31002:SF34 SERIPAUPERIN CELL WALL PROTEIN CWP1-RELATED HELRO|EnsemblGenome=HelroG173825|UniProtKB=T1F7A3 T1F7A3 20204702 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG183091|UniProtKB=T1FJ53 T1FJ53 20208852 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190918|UniProtKB=T1FSF1 T1FSF1 20211748 PTHR11361:SF35 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN SPELLCHECKER 1 ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;catalytic activity, acting on DNA#GO:0140097 mitotic recombination#GO:0006312;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG180009|UniProtKB=T1FFC4 T1FFC4 20207523 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG139996|UniProtKB=T1EIZ6 T1EIZ6 20196546 PTHR22600:SF59 BETA-HEXOSAMINIDASE BETA-HEXOSAMINIDASE A hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;glycosaminoglycan metabolic process#GO:0030203;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;extracellular region#GO:0005576;intracellular organelle#GO:0043229 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG180801|UniProtKB=T1FGA8 T1FGA8 20207857 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG71336|UniProtKB=T1G0J8 T1G0J8 20214596 PTHR31826:SF0 NICALIN NICALIN regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG169005|UniProtKB=T1F191 T1F191 20202591 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN channel regulator activity#GO:0016247;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transmission of nerve impulse#GO:0019226;system process#GO:0003008;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of synaptic transmission#GO:0050806;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;cell communication#GO:0007154;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;regulation of biological quality#GO:0065008 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634 voltage-gated ion channel#PC00241;transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG168624|UniProtKB=T1F0T0 T1F0T0 20202430 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG132900|UniProtKB=T1EHZ9 T1EHZ9 20196199 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096 cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;response to fibroblast growth factor#GO:0071774;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174195|UniProtKB=T1F7R6 T1F7R6 20204865 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG76381|UniProtKB=T1G2J4 T1G2J4 20215292 PTHR18834:SF2 STEROID RECEPTOR RNA ACTIVATOR 1 STEROID RECEPTOR RNA ACTIVATOR 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG156911|UniProtKB=T1EM31 T1EM31 20197631 PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363 proteinogenic amino acid biosynthetic process#GO:0170038;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;carboxylic acid metabolic process#GO:0019752;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 lyase#PC00144;metabolite interconversion enzyme#PC00262 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HELRO|EnsemblGenome=HelroG95625|UniProtKB=T1G970 T1G970 20217617 PTHR11829:SF411 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN L2 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG186227|UniProtKB=T1FNU4 T1FNU4 20210491 PTHR12302:SF2 EBNA2 BINDING PROTEIN P100 STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1 nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG77283|UniProtKB=T1G2V6 T1G2V6 20215404 PTHR22980:SF0 CORTISTATIN CENTROMERE PROTEIN S chromatin binding#GO:0003682;binding#GO:0005488 reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;meiosis I#GO:0007127;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;DNA replication#GO:0006260;DNA-templated DNA replication#GO:0006261;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 neuropeptide#PC00162;peptide hormone#PC00179 HELRO|EnsemblGenome=HelroG192423|UniProtKB=T1FTY1 T1FTY1 20212278 PTHR12412:SF2 CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG162134|UniProtKB=T1ES99 T1ES99 20199449 PTHR11324:SF16 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN 2 interleukin superfamily#PC00128;cytokine#PC00083 HELRO|EnsemblGenome=HelroG155580|UniProtKB=T1ELJ1 T1ELJ1 20197441 PTHR11278:SF0 40S RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN ES7 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274 ribosome#GO:0005840;small-subunit processome#GO:0032040;cytosolic ribosome#GO:0022626;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG111117|UniProtKB=T1EF84 T1EF84 20195236 PTHR12616:SF8 VACUOLAR PROTEIN SORTING VPS41 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 vesicle fusion#GO:0006906;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular component organization#GO:0016043;vesicle organization#GO:0016050;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;late endosome#GO:0005770;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166355|UniProtKB=T1EY18 T1EY18 20201468 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174682|UniProtKB=T1F8D2 T1F8D2 20205081 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG133424|UniProtKB=T1EI09 T1EI09 20196209 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180314|UniProtKB=T1FFQ3 T1FFQ3 20207652 PTHR31034:SF2 TRANSMEMBRANE PROTEIN 101 TRANSMEMBRANE PROTEIN 101 HELRO|EnsemblGenome=HelroG154769|UniProtKB=T1ELG1 T1ELG1 20197411 PTHR21737:SF4 POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3 SPLICING FACTOR CACTIN mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG69178|UniProtKB=T1FZQ6 T1FZQ6 20214304 PTHR12995:SF4 FI21814P1 FI21814P1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG65855|UniProtKB=T1FYD7 T1FYD7 20213835 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;bicarbonate transmembrane transporter activity#GO:0015106 homeostatic process#GO:0042592;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;chemical homeostasis#GO:0048878 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG184852|UniProtKB=T1FM31 T1FM31 20209880 PTHR10252:SF156 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>NF-Y#P06742 HELRO|EnsemblGenome=HelroG99817|UniProtKB=T1G9V4 T1G9V4 20217850 PTHR43975:SF2 ZGC:101858 DEHYDROGENASES, SHORT CHAIN HELRO|EnsemblGenome=HelroG105627|UniProtKB=T1EDW8 T1EDW8 20194770 PTHR21355:SF0 G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2 LMBR1 DOMAIN-CONTAINING PROTEIN 2 HOMOLOG membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG111636|UniProtKB=T1EFD0 T1EFD0 20195282 PTHR13793:SF160 PHD FINGER PROTEINS PHD FINGER PROTEIN RHINOCEROS chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186014|UniProtKB=T1FNJ8 T1FNJ8 20210395 PTHR45683:SF18 MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 32 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG94668|UniProtKB=T1G921 T1G921 20217568 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG86826|UniProtKB=T1G6H6 T1G6H6 20216673 PTHR45797:SF3 RAD54-LIKE ATP-DEPENDENT HELICASE ATRX catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094;transcription regulator activity#GO:0140110;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;catalytic activity, acting on a nucleic acid#GO:0140640 chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG144059|UniProtKB=T1EJD5 T1EJD5 20196685 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;plasma membrane bounded cell projection assembly#GO:0120031;cellular developmental process#GO:0048869;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;gamete generation#GO:0007276;spermatid differentiation#GO:0048515;cilium organization#GO:0044782 cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;organelle#GO:0043226;motile cilium#GO:0031514;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729 HELRO|EnsemblGenome=HelroG181546|UniProtKB=T1FH33 T1FH33 20208132 PTHR28573:SF1 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1 SKA COMPLEX SUBUNIT 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of microtubule-based process#GO:0032886;chromosome segregation#GO:0007059;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;cellular process#GO:0009987;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;kinetochore#GO:0000776;chromosome#GO:0005694;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;spindle#GO:0005819;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;outer kinetochore#GO:0000940;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080 HELRO|EnsemblGenome=HelroG84744|UniProtKB=T1G5N1 T1G5N1 20216378 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;exonuclease activity#GO:0004527;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;3'-5' exonuclease activity#GO:0008408;DNA exonuclease activity#GO:0004529 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG76128|UniProtKB=T1G2F4 T1G2F4 20215252 PTHR10838:SF34 SYNAPTOGYRIN SYNAPTOGYRIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;cell junction#GO:0030054;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG97921|UniProtKB=T1G9J5 T1G9J5 20217741 PTHR24068:SF565 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG73849|UniProtKB=T1G1J4 T1G1J4 20214942 PTHR10574:SF365 NETRIN/LAMININ-RELATED NETRIN-A-RELATED dendrite development#GO:0016358;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tissue development#GO:0009888;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HELRO|EnsemblGenome=HelroG88668|UniProtKB=T1G752 T1G752 20216899 PTHR46202:SF1 DNA EXCISION REPAIR PROTEIN ERCC-8 DNA EXCISION REPAIR PROTEIN ERCC-8 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;nucleotide-excision repair#GO:0006289;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;DNA repair#GO:0006281;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;nucleotide-excision repair complex#GO:0000109;protein-containing complex#GO:0032991;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185921|UniProtKB=T1FNF9 T1FNF9 20210356 PTHR22768:SF0 DNA REPLICATION COMPLEX GINS PROTEIN PSF3 DNA REPLICATION COMPLEX GINS PROTEIN PSF3 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;DNA replication#GO:0006260;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;GINS complex#GO:0000811;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;DNA replication preinitiation complex#GO:0031261;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG84138|UniProtKB=T1G5F2 T1G5F2 20216299 PTHR21162:SF0 P53 AND DNA DAMAGE-REGULATED PROTEIN P53 AND DNA DAMAGE-REGULATED PROTEIN 1 HELRO|EnsemblGenome=HelroG83777|UniProtKB=T1G5A1 T1G5A1 20216248 PTHR35268:SF1 PROTEIN CCSMST1 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 4 cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex III assembly#GO:0034551;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG191497|UniProtKB=T1FT15 T1FT15 20211962 PTHR10159:SF541 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG170990|UniProtKB=T1F3N7 T1F3N7 20203436 PTHR11782:SF127 ADENOSINE/GUANOSINE DIPHOSPHATASE NUCLEOSIDE DIPHOSPHATE PHOSPHATASE catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;nucleoside diphosphate metabolic process#GO:0009132;metabolic process#GO:0008152;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;membrane#GO:0016020 hydrolase#PC00121;nucleotide phosphatase#PC00173;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG161726|UniProtKB=T1ERU3 T1ERU3 20199293 PTHR14787:SF1 C10ORF188 FAMILY MEMBER ATPASE PAAT hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG192509|UniProtKB=T1FU13 T1FU13 20212309 PTHR22948:SF85 TUDOR DOMAIN CONTAINING PROTEIN RE73736P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179421|UniProtKB=T1FEP0 T1FEP0 20207289 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165024|UniProtKB=T1EW57 T1EW57 20200807 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165060|UniProtKB=T1EW82 T1EW82 20200832 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194976|UniProtKB=T1FWM3 T1FWM3 20213218 PTHR19441:SF95 WAP four-disulfide core domain protein ANTISTASIN-LIKE DOMAIN-CONTAINING PROTEIN endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG165856|UniProtKB=T1EXD2 T1EXD2 20201232 PTHR12461:SF53 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED JMJC DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65080|UniProtKB=T1FY30 T1FY30 20213728 PTHR12245:SF7 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catabolic process#GO:0009056;synapse assembly#GO:0007416;cell junction organization#GO:0034330;modification-dependent protein catabolic process#GO:0019941;cell junction assembly#GO:0034329;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;system development#GO:0048731;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;synapse organization#GO:0050808;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;animal gross anatomical part developmental process#GO:0160108;proteasomal protein catabolic process#GO:0010498;nervous system development#GO:0007399;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;ubiquitin-dependent protein catabolic process#GO:0006511;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 ubiquitin ligase complex#GO:0000151;cell junction#GO:0030054;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157126|UniProtKB=T1EM67 T1EM67 20197667 PTHR47980:SF23 LD44762P SMALL MONOMERIC GTPASE endocytic recycling#GO:0032456;export from cell#GO:0140352;secretion#GO:0046903;cellular localization#GO:0051641;localization#GO:0051179;secretion by cell#GO:0032940;localization within membrane#GO:0051668;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;exocytosis#GO:0006887;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;secretory vesicle#GO:0099503 TGF-beta signaling pathway#P00052>Ras-GTP#P01280;TGF-beta signaling pathway#P00052>Ras-GDP#P01291 HELRO|EnsemblGenome=HelroG185592|UniProtKB=T1FN05 T1FN05 20210204 PTHR13338:SF4 UPF0240 PROTEIN NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4 NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG184947|UniProtKB=T1FM72 T1FM72 20209921 PTHR13768:SF2 SOLUBLE NSF ATTACHMENT PROTEIN SNAP GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG110282|UniProtKB=T1EF10 T1EF10 20195162 PTHR46091:SF3 BLR7054 PROTEIN ALL-TRANS-RETINOL 13,14-REDUCTASE HELRO|EnsemblGenome=HelroG169214|UniProtKB=T1F1L1 T1F1L1 20202711 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185227|UniProtKB=T1FMJ2 T1FMJ2 20210041 PTHR12226:SF5 MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN oligosaccharide metabolic process#GO:0009311;oligosaccharide biosynthetic process#GO:0009312;metabolic process#GO:0008152;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;cellular process#GO:0009987;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG190986|UniProtKB=T1FSH1 T1FSH1 20211768 PTHR16195:SF16 ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14 HELRO|EnsemblGenome=HelroG193359|UniProtKB=T1FUW9 T1FUW9 20212615 PTHR21136:SF221 SNARE PROTEINS VESICLE-ASSOCIATED MEMBRANE PROTEIN 9 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;vesicle fusion#GO:0006906;organelle membrane fusion#GO:0090174 vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 SNARE protein#PC00034;membrane traffic protein#PC00150 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072 HELRO|EnsemblGenome=HelroG66915|UniProtKB=T1FYS8 T1FYS8 20213976 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG169848|UniProtKB=T1F2D5 T1F2D5 20202985 PTHR18947:SF39 HOOK PROTEINS PROTEIN HOOK protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG183843|UniProtKB=T1FK94 T1FK94 20209243 PTHR14024:SF49 PERILIPIN LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;lipid storage#GO:0019915;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of localization#GO:0032879 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166363|UniProtKB=T1EY21 T1EY21 20201471 PTHR46560:SF5 CYPHER, ISOFORM B ZP DOMAIN-CONTAINING PROTEIN developmental process#GO:0032502;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;cell morphogenesis#GO:0000902 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG64710|UniProtKB=T1FXY2 T1FXY2 20213680 PTHR20940:SF1 TETRA THYMOSIN CIBOULOT, ISOFORM A actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin monomer binding#GO:0003785;binding#GO:0005488;protein binding#GO:0005515 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185387|UniProtKB=T1FMR2 T1FMR2 20210111 PTHR15497:SF1 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE oxygenase#PC00177 HELRO|EnsemblGenome=HelroG71683|UniProtKB=T1G0Q2 T1G0Q2 20214650 PTHR11662:SF461 SOLUTE CARRIER FAMILY 17 MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG180890|UniProtKB=T1FGD3 T1FGD3 20207882 PTHR15075:SF2 ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG166662|UniProtKB=T1EYB9 T1EYB9 20201569 PTHR23019:SF3 NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG74592|UniProtKB=T1G1T1 T1G1T1 20215029 PTHR24243:SF241 G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDES CAPA RECEPTOR neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG105775|UniProtKB=T1EDX5 T1EDX5 20194777 PTHR12286:SF5 SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE liposaccharide metabolic process#GO:1903509;lipid biosynthetic process#GO:0008610;glycolipid metabolic process#GO:0006664;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycolipid biosynthetic process#GO:0009247;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115387|UniProtKB=T1EG78 T1EG78 20195580 PTHR42758:SF4 PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 1 phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689 glycerophospholipid catabolic process#GO:0046475;organophosphate catabolic process#GO:0046434;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;glycerolipid catabolic process#GO:0046503;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 lipase#PC00143;phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG164968|UniProtKB=T1EW12 T1EW12 20200762 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173734|UniProtKB=T1F763 T1F763 20204662 PTHR10585:SF14 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR signal sequence receptor activity#GO:0005048 macromolecule localization#GO:0033036;cellular process#GO:0009987;protein localization to organelle#GO:0033365;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG86941|UniProtKB=T1G6J5 T1G6J5 20216692 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG169215|UniProtKB=T1F1L2 T1F1L2 20202712 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161468|UniProtKB=T1ERI0 T1ERI0 20199180 PTHR24341:SF6 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN INVECTED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG77859|UniProtKB=T1G348 T1G348 20215496 PTHR10807:SF109 MYOTUBULARIN-RELATED SET DOMAIN BINDING FACTOR, ISOFORM A catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;phosphoric ester hydrolase activity#GO:0042578;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234 phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG166969|UniProtKB=T1EYT9 T1EYT9 20201739 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192123|UniProtKB=T1FTL5 T1FTL5 20212162 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN YEATS DOMAIN-CONTAINING PROTEIN binding#GO:0005488;chromatin binding#GO:0003682 regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891 intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG181599|UniProtKB=T1FH55 T1FH55 20208154 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG180512|UniProtKB=T1FG01 T1FG01 20207750 PTHR47186:SF61 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57 PROTEIN LAP1 HELRO|EnsemblGenome=HelroG185885|UniProtKB=T1FNE3 T1FNE3 20210340 PTHR11588:SF499 TUBULIN TUBULIN ALPHA CHAIN-LIKE 3 purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG183049|UniProtKB=T1FJ39 T1FJ39 20208838 PTHR10166:SF43 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VWA N-TERMINAL DOMAIN-CONTAINING PROTEIN voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;calcium channel complex#GO:0034704;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG173516|UniProtKB=T1F6X2 T1F6X2 20204571 PTHR23308:SF36 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 SMAD NUCLEAR-INTERACTING PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA splicing factor#PC00148 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG169344|UniProtKB=T1F1T1 T1F1T1 20202781 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192311|UniProtKB=T1FTT5 T1FTT5 20212232 PTHR22642:SF2 IMIDAZOLONEPROPIONASE PROTEIN LONG AFTER FAR-RED 3 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183218|UniProtKB=T1FJB9 T1FJB9 20208918 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG177544|UniProtKB=T1FBV1 T1FBV1 20206300 PTHR45749:SF44 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1 HELRO|EnsemblGenome=HelroG164470|UniProtKB=T1EVG6 T1EVG6 20200566 PTHR37487:SF3 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE VITELLOGENIN II HELRO|EnsemblGenome=HelroG87508|UniProtKB=T1G6R2 T1G6R2 20216759 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG191649|UniProtKB=T1FT63 T1FT63 20212010 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG111583|UniProtKB=T1EFC6 T1EFC6 20195278 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488 localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG156074|UniProtKB=T1ELR4 T1ELR4 20197514 PTHR24070:SF457 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE PROTEIN 2 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;establishment or maintenance of cell polarity#GO:0007163;Ras protein signal transduction#GO:0007265 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;TGF-beta signaling pathway#P00052>Ras-GDP#P01291;PDGF signaling pathway#P00047>Ras#P01154;EGF receptor signaling pathway#P00018>Ras#P00552 HELRO|EnsemblGenome=HelroG71264|UniProtKB=T1G0I5 T1G0I5 20214583 PTHR12733:SF3 MITOCHONDRIAL ATP SYNTHASE B CHAIN ATP SYNTHASE PERIPHERAL STALK SUBUNIT B, MITOCHONDRIAL monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;proton channel activity#GO:0015252;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 organophosphate biosynthetic process#GO:0090407;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;proton-transporting ATP synthase complex#GO:0045259;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743 primary active transporter#PC00068;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG127781|UniProtKB=T1EHH9 T1EHH9 20196029 PTHR23235:SF183 KRUEPPEL-LIKE TRANSCRIPTION FACTOR DENDRITIC ARBOR REDUCTION PROTEIN 1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG172159|UniProtKB=T1F532 T1F532 20203931 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG63763|UniProtKB=T1FXK0 T1FXK0 20213548 PTHR12992:SF11 NUDIX HYDROLASE MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;sulfur compound catabolic process#GO:0044273;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;organophosphate catabolic process#GO:0046434 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG191505|UniProtKB=T1FT19 T1FT19 20211966 PTHR13064:SF6 TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER TRANSMEMBRANE PROTEIN 9 HELRO|EnsemblGenome=HelroG90895|UniProtKB=T1G7X6 T1G7X6 20217173 PTHR45638:SF25 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A monoatomic cation channel activity#GO:0005261;nucleotide binding#GO:0000166;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;channel activity#GO:0015267;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;purine ribonucleotide binding#GO:0032555;monoatomic ion transmembrane transporter activity#GO:0015075;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;monoatomic cation transmembrane transporter activity#GO:0008324;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836 multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;transport#GO:0006810;sensory perception#GO:0007600 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG186399|UniProtKB=T1FNZ1 T1FNZ1 20210538 PTHR11730:SF60 AMMONIUM TRANSPORTER RH50, ISOFORM D channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;homeostatic process#GO:0042592;transport#GO:0006810;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG101733|UniProtKB=T1ED65 T1ED65 20194517 PTHR10746:SF18 50S RIBOSOMAL PROTEIN L4 LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;positive regulation of Notch signaling pathway#GO:0045747;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;post-transcriptional regulation of gene expression#GO:0010608;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG79022|UniProtKB=T1G3I6 T1G3I6 20215634 PTHR23113:SF224 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 signaling#GO:0023052;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of cellular component organization#GO:0051130;positive regulation of cell projection organization#GO:0031346;positive regulation of neuron projection development#GO:0010976;Ras protein signal transduction#GO:0007265;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 Integrin signalling pathway#P00034>C3G#P00929 HELRO|EnsemblGenome=HelroG172418|UniProtKB=T1F5A8 T1F5A8 20204007 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78102|UniProtKB=T1G378 T1G378 20215526 PTHR10445:SF0 GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIFbeta#P00667;Transcription regulation by bZIP transcription factor#P00055>TFIIFbeta#P01396 HELRO|EnsemblGenome=HelroG184927|UniProtKB=T1FM61 T1FM61 20209910 PTHR23105:SF38 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER NHP2-LIKE PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA splicing, via transesterification reactions#GO:0000375 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;spliceosomal complex#GO:0005681;small-subunit processome#GO:0032040;spliceosomal snRNP complex#GO:0097525;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;precatalytic spliceosome#GO:0071011;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG149301|UniProtKB=T1EKC5 T1EKC5 20197025 PTHR22455:SF10 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 HELRO|EnsemblGenome=HelroG89692|UniProtKB=T1G7G0 T1G7G0 20217007 PTHR12263:SF0 VACUOLAR ATP SYNTHASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;membrane#GO:0016020 primary active transporter#PC00068;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG74975|UniProtKB=T1G1Z0 T1G1Z0 20215088 PTHR45694:SF5 GLUTAREDOXIN 2 GLUTAREDOXIN-C4 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491 response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to oxidative stress#GO:0034599;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193729|UniProtKB=T1FVA8 T1FVA8 20212754 PTHR15832:SF2 SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG SH2 DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170048|UniProtKB=T1F2K9 T1F2K9 20203058 PTHR12945:SF0 TRANSLATION INITIATION FACTOR EIF3-RELATED TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;methyltransferase complex#GO:0034708;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG180444|UniProtKB=T1FFX2 T1FFX2 20207721 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG107371|UniProtKB=T1EEA2 T1EEA2 20194904 PTHR10768:SF0 60S RIBOSOMAL PROTEIN L37 RIBOSOMAL PROTEIN L37 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG170964|UniProtKB=T1F3M8 T1F3M8 20203427 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H nuclease activity#GO:0004518;hydrolase activity#GO:0016787;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;endoribonuclease#PC00094 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG178929|UniProtKB=T1FDX0 T1FDX0 20207019 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN FUCOLECTIN-6-LIKE HELRO|EnsemblGenome=HelroG71528|UniProtKB=T1G0M7 T1G0M7 20214625 PTHR24244:SF1 NEUROPEPTIDE S RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG68394|UniProtKB=T1FZE0 T1FZE0 20214188 PTHR12786:SF2 SPLICING FACTOR SF3A-RELATED SPLICING FACTOR 3A SUBUNIT 3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 U2 snRNP#GO:0005686;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG128607|UniProtKB=T1EHP0 T1EHP0 20196090 PTHR13639:SF2 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 chaperone#PC00072 HELRO|EnsemblGenome=HelroG92410|UniProtKB=T1G8F8 T1G8F8 20217355 PTHR45636:SF49 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED SEGMENTATION PROTEIN PAIRED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG189017|UniProtKB=T1FQK5 T1FQK5 20211102 PTHR23231:SF17 GERM CELL-LESS PROTEIN GERM CELL-LESS 1, SPERMATOSIS ASSOCIATED ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG95386|UniProtKB=T1G955 T1G955 20217602 PTHR10218:SF362 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA O SUBUNIT ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid prodynorphin pathway#P05916>G-protein#P06002;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085 HELRO|EnsemblGenome=HelroG172715|UniProtKB=T1F5U3 T1F5U3 20204192 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75164|UniProtKB=T1G218 T1G218 20215116 PTHR24033:SF193 EGF-LIKE DOMAIN-CONTAINING PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8 HELRO|EnsemblGenome=HelroG85228|UniProtKB=T1G5U5 T1G5U5 20216442 PTHR12027:SF102 WNT RELATED PROTEIN WNT molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;system development#GO:0048731;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HELRO|EnsemblGenome=HelroG174891|UniProtKB=T1F8K9 T1F8K9 20205158 PTHR16057:SF1 WINS1, 2 PROTEIN PROTEIN LINES HOMOLOG 1 HELRO|EnsemblGenome=HelroG171365|UniProtKB=T1F466 T1F466 20203615 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG64824|UniProtKB=T1FXZ8 T1FXZ8 20213696 PTHR12645:SF0 ALR/ERV SULFHYDRYL OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;heterocyclic compound binding#GO:1901363;disulfide oxidoreductase activity#GO:0015036;nucleotide binding#GO:0000166;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;small molecule binding#GO:0036094;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;protein-disulfide reductase activity#GO:0015035 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG89836|UniProtKB=T1G7I2 T1G7I2 20217029 PTHR11829:SF402 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG189995|UniProtKB=T1FRK6 T1FRK6 20211453 PTHR25465:SF31 B-BOX DOMAIN CONTAINING E3 UBIQUITIN-PROTEIN LIGASE MIDLINE-1-LIKE ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG68267|UniProtKB=T1FZC3 T1FZC3 20214171 PTHR31547:SF1 MULTIVESICULAR BODY SUBUNIT 12B MULTIVESICULAR BODY SUBUNIT 12B regulation of cellular process#GO:0050794;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;endomembrane system#GO:0012505;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HELRO|EnsemblGenome=HelroG163669|UniProtKB=T1EUC3 T1EUC3 20200173 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN CC8L18.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG185158|UniProtKB=T1FMG4 T1FMG4 20210013 PTHR10410:SF6 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED COP9 SIGNALOSOME COMPLEX SUBUNIT 5 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 translation factor#PC00223;translation initiation factor#PC00224 PDGF signaling pathway#P00047>c-Jun#P01163 HELRO|EnsemblGenome=HelroG105641|UniProtKB=T1EDX0 T1EDX0 20194772 PTHR10554:SF12 SYNTROPHIN IP02644P plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG151014|UniProtKB=T1EKI2 T1EKI2 20197082 PTHR35365:SF13 LP04239P SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG173745|UniProtKB=T1F768 T1F768 20204667 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG168109|UniProtKB=T1F063 T1F063 20202213 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114574|UniProtKB=T1EG31 T1EG31 20195533 PTHR43731:SF14 RHOMBOID PROTEASE PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 serine protease#PC00203 HELRO|EnsemblGenome=HelroG192806|UniProtKB=T1FUB4 T1FUB4 20212410 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING-TYPE E3 UBIQUITIN TRANSFERASE acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG183684|UniProtKB=T1FK11 T1FK11 20209160 PTHR46927:SF4 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG175621|UniProtKB=T1F9F8 T1F9F8 20205457 PTHR10827:SF52 RETICULOCALBIN RETICULOCALBIN-3 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG180065|UniProtKB=T1FFF6 T1FFF6 20207555 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162228|UniProtKB=T1ESD8 T1ESD8 20199488 PTHR46181:SF3 MITOCHONDRIAL GLYCINE TRANSPORTER MITOCHONDRIAL GLYCINE TRANSPORTER neutral L-amino acid transmembrane transporter activity#GO:0015175;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171;glycine transmembrane transporter activity#GO:0015187 mitochondrial transmembrane transport#GO:1990542;glycine transport#GO:0015816;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;cellular localization#GO:0051641;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039;intracellular transport#GO:0046907;organic acid transport#GO:0015849;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;transport#GO:0006810;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227 HELRO|EnsemblGenome=HelroG191019|UniProtKB=T1FSI2 T1FSI2 20211779 PTHR45696:SF10 60S ACIDIC RIBOSOMAL PROTEIN P1 LARGE RIBOSOMAL SUBUNIT PROTEIN P1 protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;structural constituent of ribosome#GO:0003735;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;structural molecule activity#GO:0005198;protein kinase regulator activity#GO:0019887;kinase activator activity#GO:0019209;binding#GO:0005488;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;enzyme regulator activity#GO:0030234 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG166503|UniProtKB=T1EY67 T1EY67 20201517 PTHR12991:SF10 NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4 GATOR1 COMPLEX PROTEIN NPRL2 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;negative regulation of TORC1 signaling#GO:1904262;regulation of TORC1 signaling#GO:1903432;response to stress#GO:0006950;response to nutrient levels#GO:0031667;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;cellular response to amino acid starvation#GO:0034198;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Seh1-associated complex#GO:0035859;vacuolar membrane#GO:0005774;intracellular organelle#GO:0043229 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG182462|UniProtKB=T1FI84 T1FI84 20208533 PTHR16021:SF13 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1-RELATED HELRO|EnsemblGenome=HelroG110053|UniProtKB=T1EEY8 T1EEY8 20195140 PTHR10887:SF5 DNA2/NAM7 HELICASE FAMILY RNA HELICASE AQUARIUS RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG96655|UniProtKB=T1G9D1 T1G9D1 20217678 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG194540|UniProtKB=T1FW64 T1FW64 20213060 PTHR47020:SF1 HILLARIN HILLARIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186140|UniProtKB=T1FNQ1 T1FNQ1 20210448 PTHR22762:SF131 ALPHA-GLUCOSIDASE LYSOSOMAL ALPHA-GLUCOSIDASE-LIKE alpha-glucosidase activity#GO:0090599;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;glucosidase activity#GO:0015926 glucosidase#PC00108 HELRO|EnsemblGenome=HelroG172479|UniProtKB=T1F5D6 T1F5D6 20204035 PTHR15670:SF8 RHO GTPASE ACTIVATING PROTEIN 11A RHO-GAP DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG169535|UniProtKB=T1F220 T1F220 20202870 PTHR21505:SF12 MADF DOMAIN-CONTAINING PROTEIN-RELATED MADF DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG91240|UniProtKB=T1G815 T1G815 20217212 PTHR10584:SF166 SUGAR KINASE RIBOKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;carbohydrate kinase activity#GO:0019200 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065;kinase#PC00137 HELRO|EnsemblGenome=HelroG147263|UniProtKB=T1EJY8 T1EJY8 20196888 PTHR11058:SF26 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 electron transfer activity#GO:0009055;monoatomic cation transmembrane transporter activity#GO:0008324;oxidoreductase activity, acting on NAD(P)H#GO:0016651;NADH dehydrogenase activity#GO:0003954;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG107810|UniProtKB=T1EEC8 T1EEC8 20194930 PTHR31441:SF3 FOLLICULIN FAMILY MEMBER FOLLICULIN enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of TOR signaling#GO:0032008;regulation of DNA-templated transcription#GO:0006355;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of TORC1 signaling#GO:1903432;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of TORC1 signaling#GO:1904263;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of signaling#GO:0023056;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG106340|UniProtKB=T1EE22 T1EE22 20194824 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cell fate specification#GO:0001708;plasma membrane bounded cell projection morphogenesis#GO:0120039;positive regulation of transcription by RNA polymerase II#GO:0045944;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;cell fate commitment#GO:0045165;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG185541|UniProtKB=T1FMY4 T1FMY4 20210183 PTHR15241:SF394 TRANSFORMER-2-RELATED POLYADENYLATE-BINDING PROTEIN RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG72412|UniProtKB=T1G0Z6 T1G0Z6 20214744 PTHR21396:SF2 39S RIBOSOMAL PROTEIN L43 LARGE RIBOSOMAL SUBUNIT PROTEIN ML43 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG180867|UniProtKB=T1FGC6 T1FGC6 20207875 PTHR45776:SF2 MIP04163P MIP04163P DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG72339|UniProtKB=T1G0Y6 T1G0Y6 20214734 PTHR11040:SF223 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG179222|UniProtKB=T1FED7 T1FED7 20207186 PTHR13551:SF1 BRAIN PROTEIN I3 MEMBRANE PROTEIN BRI3 HELRO|EnsemblGenome=HelroG190865|UniProtKB=T1FSD3 T1FSD3 20211730 PTHR43811:SF63 FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA 39 KDA FK506-BINDING NUCLEAR PROTEIN peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 chaperone#PC00072 HELRO|EnsemblGenome=HelroG111430|UniProtKB=T1EFB3 T1EFB3 20195265 PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;sulfur compound metabolic process#GO:0006790;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 lyase#PC00144;metabolite interconversion enzyme#PC00262 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HELRO|EnsemblGenome=HelroG182038|UniProtKB=T1FHM7 T1FHM7 20208326 PTHR11132:SF255 SOLUTE CARRIER FAMILY 35 GDP-FUCOSE TRANSPORTER 1 active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nucleotide-sugar transmembrane transport#GO:0015780;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG163766|UniProtKB=T1EUG0 T1EUG0 20200210 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 dynein complex#GO:0030286;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG124318|UniProtKB=T1EH10 T1EH10 20195860 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68539|UniProtKB=T1FZG5 T1FZG5 20214213 PTHR46461:SF1 KELCH DOMAIN-CONTAINING PROTEIN 3 KELCH DOMAIN-CONTAINING PROTEIN 3 chromatin binding#GO:0003682;binding#GO:0005488 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG163912|UniProtKB=T1EUM1 T1EUM1 20200271 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191798|UniProtKB=T1FTC1 T1FTC1 20212068 PTHR13477:SF0 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49 LARGE RIBOSOMAL SUBUNIT PROTEIN ML49 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG172979|UniProtKB=T1F686 T1F686 20204335 PTHR10773:SF19 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 DUF7869 DOMAIN-CONTAINING PROTEIN DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG109692|UniProtKB=T1EEV7 T1EEV7 20195109 PTHR43107:SF27 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN-FATTY-ACID--COA LIGASE ATP-dependent activity#GO:0140657;carboxylic acid transmembrane transporter activity#GO:0046943;ligase activity, forming carbon-sulfur bonds#GO:0016877;monocarboxylic acid transmembrane transporter activity#GO:0008028;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;lipid metabolic process#GO:0006629;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;macromolecule localization#GO:0033036;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid transport#GO:0006869 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG175377|UniProtKB=T1F977 T1F977 20205376 PTHR34586:SF3 SPERACT/SCAVENGER RECEPTOR DOMAIN-CONTAINING PROTEIN FOLLISTATIN-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193090|UniProtKB=T1FUM1 T1FUM1 20212517 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG181303|UniProtKB=T1FGV5 T1FGV5 20208054 PTHR47018:SF4 CXC DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG193760|UniProtKB=T1FVB9 T1FVB9 20212765 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181360|UniProtKB=T1FGX4 T1FGX4 20208073 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA stabilization#GO:0043489;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA stability#GO:0043487;negative regulation of catabolic process#GO:0009895;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;negative regulation of RNA catabolic process#GO:1902369;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG180364|UniProtKB=T1FFU2 T1FFU2 20207691 PTHR22792:SF159 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 7 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191975|UniProtKB=T1FTH2 T1FTH2 20212119 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG74654|UniProtKB=T1G1T7 T1G1T7 20215035 PTHR20955:SF1 PROTEIN JAGUNAL HOMOLOG 1 PROTEIN JAGUNAL organelle organization#GO:0006996;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG92804|UniProtKB=T1G8L3 T1G8L3 20217410 PTHR43907:SF1 SLEI FAMILY PROTEIN DYNEIN HEAVY CHAIN HELRO|EnsemblGenome=HelroG157216|UniProtKB=T1EM84 T1EM84 20197684 PTHR22883:SF43 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE APP palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169094|UniProtKB=T1F1D9 T1F1D9 20202639 PTHR13866:SF14 SPARC OSTEONECTIN BM-40 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG194343|UniProtKB=T1FVY5 T1FVY5 20212981 PTHR22803:SF180 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN-RELATED membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG172045|UniProtKB=T1F4Z1 T1F4Z1 20203890 PTHR24403:SF67 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG170295|UniProtKB=T1F2W2 T1F2W2 20203161 PTHR12428:SF70 OXA1 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 membrane organization#GO:0061024;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;protein insertion into membrane#GO:0051205;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;protein localization to organelle#GO:0033365;protein-containing complex assembly#GO:0065003;protein localization to mitochondrion#GO:0070585;cellular component organization#GO:0016043;respiratory chain complex IV assembly#GO:0008535;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668 mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG160206|UniProtKB=T1EPZ1 T1EPZ1 20198641 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG192497|UniProtKB=T1FU10 T1FU10 20212306 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG192686|UniProtKB=T1FU70 T1FU70 20212366 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cellular process#GO:0009987;cell migration#GO:0016477;endothelial cell migration#GO:0043542;cell motility#GO:0048870 vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191640|UniProtKB=T1FT58 T1FT58 20212005 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;negative regulation of cell communication#GO:0010648 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HELRO|EnsemblGenome=HelroG122321|UniProtKB=T1EGU5 T1EGU5 20195795 PTHR11073:SF2 CALRETICULIN AND CALNEXIN CALRETICULIN calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to chemical#GO:0042221;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;proteasomal protein catabolic process#GO:0010498;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein folding#GO:0006457 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 chaperone#PC00072 HELRO|EnsemblGenome=HelroG192895|UniProtKB=T1FUE2 T1FUE2 20212438 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED FI18012P1 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG165207|UniProtKB=T1EWF7 T1EWF7 20200907 PTHR23196:SF42 PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN PAX-INTERACTING PROTEIN 1 response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG178963|UniProtKB=T1FDZ3 T1FDZ3 20207042 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193870|UniProtKB=T1FVF6 T1FVF6 20212802 PTHR10666:SF438 UBIQUITIN UBIQUITIN-RIBOSOMAL PROTEIN ES31 FUSION PROTEIN structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;ribosome#GO:0005840;nucleus#GO:0005634;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG158731|UniProtKB=T1EN60 T1EN60 20198010 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192737|UniProtKB=T1FU88 T1FU88 20212384 PTHR11588:SF4 TUBULIN TUBULIN DELTA CHAIN purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167 mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226 tubulin#PC00228;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG91302|UniProtKB=T1G822 T1G822 20217219 PTHR11735:SF6 TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG173646|UniProtKB=T1F731 T1F731 20204630 PTHR10836:SF76 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491;glyceraldehyde-3-phosphate dehydrogenase (phosphorylating, [NAD(P)+] ) activity#GO:0043891 purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ADP catabolic process#GO:0046032;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine-containing compound catabolic process#GO:0072523;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleotide catabolic process#GO:0009166;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 Huntington disease#P00029>GAPDH#P00810;Glycolysis#P00024>Glyceraldehyde 3-phosphate dehydrogenase#P00676 HELRO|EnsemblGenome=HelroG169565|UniProtKB=T1F238 T1F238 20202888 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874 ligase#PC00142 HELRO|EnsemblGenome=HelroG178002|UniProtKB=T1FCL2 T1FCL2 20206561 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488 cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG85614|UniProtKB=T1G605 T1G605 20216502 PTHR24406:SF42 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG102694|UniProtKB=T1EDB0 T1EDB0 20194562 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of cellular process#GO:0048522;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77628|UniProtKB=T1G311 T1G311 20215459 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383 nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG163955|UniProtKB=T1EUN5 T1EUN5 20200285 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177296|UniProtKB=T1FBG9 T1FBG9 20206168 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG188104|UniProtKB=T1FPN0 T1FPN0 20210777 PTHR37431:SF3 PROTEIN CBG06927 DUF19 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184477|UniProtKB=T1FLA3 T1FLA3 20209602 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111970|UniProtKB=T1EFG1 T1EFG1 20195313 PTHR24012:SF796 RNA BINDING PROTEIN PROTEIN ALAN SHEPARD RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174094|UniProtKB=T1F7L5 T1F7L5 20204814 PTHR23257:SF994 SERINE-THREONINE PROTEIN KINASE IP11267P phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG180780|UniProtKB=T1FG97 T1FG97 20207846 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN developmental process#GO:0032502;anatomical structure development#GO:0048856 HELRO|EnsemblGenome=HelroG92436|UniProtKB=T1G8G3 T1G8G3 20217360 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG171263|UniProtKB=T1F403 T1F403 20203552 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185437|UniProtKB=T1FMT8 T1FMT8 20210137 PTHR10366:SF861 NAD DEPENDENT EPIMERASE/DEHYDRATASE 3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 dehydratase#PC00091;lyase#PC00144;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189970|UniProtKB=T1FRJ7 T1FRJ7 20211444 PTHR31780:SF10 STRESS RESPONSE PROTEIN NST1-RELATED STRESS RESPONSE PROTEIN NST1 HELRO|EnsemblGenome=HelroG99395|UniProtKB=T1G9S6 T1G9S6 20217822 PTHR10362:SF85 HISTIDINE AMMONIA-LYASE HISTIDINE AMMONIA-LYASE catalytic activity#GO:0003824;lyase activity#GO:0016829 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 lyase#PC00144 HELRO|EnsemblGenome=HelroG179778|UniProtKB=T1FF51 T1FF51 20207450 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to stress#GO:0006950;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG187061|UniProtKB=T1FP65 T1FP65 20210612 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182465|UniProtKB=T1FI86 T1FI86 20208535 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG66301|UniProtKB=T1FYJ4 T1FYJ4 20213892 PTHR10779:SF31 DYNEIN LIGHT CHAIN ROADBLOCK DYNEIN LIGHT CHAIN ROADBLOCK-TYPE 2 binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 dynein complex#GO:0030286;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG194899|UniProtKB=T1FWJ5 T1FWJ5 20213190 PTHR24135:SF30 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN LD13733P signaling adaptor activity#GO:0035591;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;cellular component organization#GO:0016043;synapse organization#GO:0050808;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794;dendritic spine#GO:0043197;dendrite#GO:0030425;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell junction#GO:0030054;synaptic membrane#GO:0097060 scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HELRO|EnsemblGenome=HelroG100087|UniProtKB=T1ECY5 T1ECY5 20194437 PTHR24007:SF7 BRCA1-ASSOCIATED PROTEIN BRCA1-ASSOCIATED PROTEIN acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;protein modification by small protein conjugation or removal#GO:0070647;Ras protein signal transduction#GO:0007265;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signal transduction#GO:0007165;post-translational protein modification#GO:0043687;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;protein ubiquitination#GO:0016567;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG80770|UniProtKB=T1G452 T1G452 20215850 PTHR12231:SF275 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell junction#GO:0030054;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG104208|UniProtKB=T1EDK4 T1EDK4 20194656 PTHR24057:SF82 GLYCOGEN SYNTHASE KINASE-3 ALPHA PROTEIN KINASE SHAGGY-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of microtubule-based process#GO:0032886;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of macromolecule metabolic process#GO:0060255;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cellular response to stimulus#GO:0051716;regulation of catabolic process#GO:0009894;cellular developmental process#GO:0048869;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of signal transduction#GO:0009968;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PDGF signaling pathway#P00047>GSK3#P01153;Angiogenesis#P00005>GSK3beta#P00211;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175 HELRO|EnsemblGenome=HelroG179526|UniProtKB=T1FEU5 T1FEU5 20207344 PTHR23301:SF0 CHITIN BINDING PERITROPHIN-A CHITINASE HELRO|EnsemblGenome=HelroG77434|UniProtKB=T1G2X6 T1G2X6 20215424 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE lyase activity#GO:0016829;molecular transducer activity#GO:0060089;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653 ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG117310|UniProtKB=T1EGL9 T1EGL9 20195719 PTHR20852:SF57 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE 2 CYTOPLASMIC ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG115822|UniProtKB=T1EGA9 T1EGA9 20195611 PTHR11353:SF84 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ALPHA metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG88781|UniProtKB=T1G763 T1G763 20216910 PTHR15243:SF0 SERINE/THREONINE-PROTEIN KINASE 19 WINGED HELIX REPAIR FACTOR 1 binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of response to stress#GO:0080134;regulation of cellular response to stress#GO:0080135 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG105460|UniProtKB=T1EDV0 T1EDV0 20194752 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987;sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG193940|UniProtKB=T1FVI0 T1FVI0 20212826 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;kinase activity#GO:0016301;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 kinase#PC00137;metabolite interconversion enzyme#PC00262 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG142066|UniProtKB=T1EJ48 T1EJ48 20196598 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG178946|UniProtKB=T1FDX9 T1FDX9 20207028 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164567|UniProtKB=T1EVK6 T1EVK6 20200606 PTHR13408:SF0 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG177704|UniProtKB=T1FC40 T1FC40 20206389 PTHR23309:SF58 3-HYDROXYACYL-COA DEHYROGENASE 3-HYDROXYACYL-COA DEHYDROGENASE NAD BINDING DOMAIN-CONTAINING PROTEIN dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188905|UniProtKB=T1FQG7 T1FQG7 20211064 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245 regulation of biological quality#GO:0065008;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154;cellular localization#GO:0051641;positive regulation of signaling#GO:0023056;localization within membrane#GO:0051668;regulation of signaling#GO:0023051;nervous system process#GO:0050877;positive regulation of synaptic transmission#GO:0050806;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;transmission of nerve impulse#GO:0019226;system process#GO:0003008;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590 voltage-gated ion channel#PC00241;transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG162955|UniProtKB=T1ETF1 T1ETF1 20199851 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG160642|UniProtKB=T1EQJ5 T1EQJ5 20198845 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG179201|UniProtKB=T1FEC6 T1FEC6 20207175 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94328|UniProtKB=T1G900 T1G900 20217547 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cell communication#GO:0007154 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG172863|UniProtKB=T1F614 T1F614 20204263 PTHR24388:SF53 ZINC FINGER PROTEIN AT-RICH BINDING PROTEIN-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG173158|UniProtKB=T1F6H0 T1F6H0 20204419 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189252|UniProtKB=T1FQV4 T1FQV4 20211201 PTHR13930:SF0 S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 lyase#PC00144 HELRO|EnsemblGenome=HelroG192867|UniProtKB=T1FUD7 T1FUD7 20212433 PTHR10758:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 COP9 SIGNALOSOME COMPLEX SUBUNIT 3 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG75835|UniProtKB=T1G2B0 T1G2B0 20215208 PTHR12878:SF0 NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193079|UniProtKB=T1FUL7 T1FUL7 20212513 PTHR15092:SF44 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 POLY(A)-SPECIFIC RIBONUCLEASE PARN catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;nucleic acid binding#GO:0003676;binding#GO:0005488;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;RNA binding#GO:0003723;nuclease activity#GO:0004518 RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulatory ncRNA processing#GO:0070918;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA processing#GO:0006396;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;RNA 3'-end processing#GO:0031123;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG72687|UniProtKB=T1G141 T1G141 20214789 PTHR21637:SF0 BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED AT10158P cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG175300|UniProtKB=T1F944 T1F944 20205343 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE cellular process#GO:0009987;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656;mitotic cell cycle#GO:0000278;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;localization#GO:0051179 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176999|UniProtKB=T1FB43 T1FB43 20206042 PTHR11311:SF30 SPONDIN KIELIN_CHORDIN-LIKE PROTEIN cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG176620|UniProtKB=T1FAQ8 T1FAQ8 20205907 PTHR10913:SF45 FOLLISTATIN-RELATED AGRIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG179523|UniProtKB=T1FEU4 T1FEU4 20207343 PTHR31547:SF1 MULTIVESICULAR BODY SUBUNIT 12B MULTIVESICULAR BODY SUBUNIT 12B regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG77344|UniProtKB=T1G2W5 T1G2W5 20215413 PTHR11246:SF1 PRE-MRNA SPLICING FACTOR PRE-MRNA-PROCESSING FACTOR 6 spliceosomal snRNP assembly#GO:0000387;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG166455|UniProtKB=T1EY55 T1EY55 20201505 PTHR11842:SF10 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 DNA polymerase complex#GO:0042575;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG66280|UniProtKB=T1FYJ0 T1FYJ0 20213888 PTHR12549:SF11 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN LYSINE-SPECIFIC DEMETHYLASE 3 binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;DNA binding#GO:0003677;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;histone demethylase activity#GO:0032452;chromatin DNA binding#GO:0031490;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;chromosome#GO:0005694 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG63809|UniProtKB=T1FXK6 T1FXK6 20213554 PTHR12473:SF17 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3 deubiquitinase activity#GO:0101005;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 HELRO|EnsemblGenome=HelroG163146|UniProtKB=T1ETQ4 T1ETQ4 20199954 PTHR24034:SF204 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG111841|UniProtKB=T1EFE9 T1EFE9 20195301 PTHR10454:SF232 CASPASE CASPASE-8 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175 positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;positive regulation of neuron apoptotic process#GO:0043525;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;apoptotic process#GO:0006915;cellular process#GO:0009987;cell death#GO:0008219;regulation of programmed cell death#GO:0043067;regulation of neuron apoptotic process#GO:0043523;programmed cell death#GO:0012501 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105218|UniProtKB=T1EDR8 T1EDR8 20194720 PTHR11566:SF237 DYNAMIN DYNAMIN GTPASE protein binding#GO:0005515;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;GTPase activity#GO:0003924;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;tubulin binding#GO:0015631 mitochondrion organization#GO:0007005;mitochondrial fission#GO:0000266;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion localization#GO:0051646;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;peroxisome organization#GO:0007031;organelle localization#GO:0051640 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;microtubule#GO:0005874;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG168139|UniProtKB=T1F078 T1F078 20202228 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87434|UniProtKB=T1G6P9 T1G6P9 20216746 PTHR10344:SF9 THYMIDYLATE KINASE THYMIDYLATE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;nucleoside diphosphate metabolic process#GO:0009132;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;mitochondrion#GO:0005739 transferase#PC00220;kinase#PC00137;nucleotide kinase#PC00172 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTMP kinase#P02916 HELRO|EnsemblGenome=HelroG156976|UniProtKB=T1EM43 T1EM43 20197643 PTHR19856:SF8 WD-REPEATCONTAINING PROTEIN WDR1 WD REPEAT-CONTAINING PROTEIN 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;protein-containing complex disassembly#GO:0032984;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;developmental process#GO:0032502;protein depolymerization#GO:0051261;actin polymerization or depolymerization#GO:0008154;striated muscle cell development#GO:0055002;cellular component disassembly#GO:0022411;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;cell development#GO:0048468;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;actin filament depolymerization#GO:0030042;cellular process#GO:0009987 actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG116835|UniProtKB=T1EGI2 T1EGI2 20195684 PTHR43920:SF11 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL CLIC monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821;monoatomic anion transport#GO:0006820 intracellular anatomical structure#GO:0005622;apical part of cell#GO:0045177;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG132800|UniProtKB=T1EHZ7 T1EHZ7 20196197 PTHR22883:SF466 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC4 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 protein targeting#GO:0006605;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186863|UniProtKB=T1FP43 T1FP43 20210590 PTHR11820:SF7 ACYLPYRUVASE OXALOACETATE TAUTOMERASE FAHD1, MITOCHONDRIAL catalytic activity#GO:0003824;hydrolase activity#GO:0016787 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG104520|UniProtKB=T1EDL9 T1EDL9 20194671 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG161372|UniProtKB=T1ERE7 T1ERE7 20199147 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81478|UniProtKB=T1G4E8 T1G4E8 20215946 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG181046|UniProtKB=T1FGK1 T1FGK1 20207950 PTHR24217:SF0 PUTATIVE-RELATED SYNAPTOPODIN 2-LIKE PROTEIN binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;regulation of response to stimulus#GO:0048583;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;positive regulation of organelle organization#GO:0010638;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130 Z disc#GO:0030018;contractile muscle fiber#GO:0043292;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;I band#GO:0031674;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG168642|UniProtKB=T1F0U1 T1F0U1 20202441 PTHR46896:SF3 SENTRIN-SPECIFIC PROTEASE FI06413P-RELATED protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG156952|UniProtKB=T1EM38 T1EM38 20197638 PTHR23427:SF1 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 4 cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG180458|UniProtKB=T1FFY1 T1FFY1 20207730 PTHR23117:SF26 GUANYLATE KINASE-RELATED GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;phosphotransferase activity, phosphate group as acceptor#GO:0016776 sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;nucleoside diphosphate metabolic process#GO:0009132;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;organophosphate biosynthetic process#GO:0090407;microtubule cytoskeleton organization#GO:0000226;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;reproductive process#GO:0022414;nucleoside phosphate metabolic process#GO:0006753;spermatogenesis#GO:0007283;developmental process#GO:0032502;purine ribonucleoside diphosphate metabolic process#GO:0009179;plasma membrane bounded cell projection assembly#GO:0120031;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;nucleotide biosynthetic process#GO:0009165;cilium organization#GO:0044782;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;small molecule metabolic process#GO:0044281;gamete generation#GO:0007276;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;carbohydrate derivative biosynthetic process#GO:1901137;cell projection assembly#GO:0030031;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;ribose phosphate biosynthetic process#GO:0046390;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG171198|UniProtKB=T1F3X5 T1F3X5 20203524 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165444|UniProtKB=T1EWT1 T1EWT1 20201031 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194237|UniProtKB=T1FVU6 T1FVU6 20212942 PTHR10332:SF88 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleoside transmembrane transporter activity#GO:0005337;carbohydrate derivative transmembrane transporter activity#GO:1901505 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG95512|UniProtKB=T1G964 T1G964 20217611 PTHR11909:SF7 CASEIN KINASE-RELATED CELL DIVISION CYCLE 7-RELATED PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;double-strand break repair via break-induced replication#GO:0000727;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell communication#GO:0007154;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG106865|UniProtKB=T1EE53 T1EE53 20194855 PTHR12300:SF161 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188900|UniProtKB=T1FQG4 T1FQG4 20211061 PTHR14398:SF0 RNA RECOGNITION RRM/RNP DOMAIN ZINC FINGER PROTEIN SWM RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG151316|UniProtKB=T1EKJ5 T1EKJ5 20197095 PTHR45751:SF53 COPINE FAMILY PROTEIN 1 VWFA DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842 protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG100373|UniProtKB=T1ECZ4 T1ECZ4 20194446 PTHR23115:SF170 TRANSLATION FACTOR ELONGATION FACTOR 1-ALPHA 2 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;translation elongation factor activity#GO:0003746;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 translation factor#PC00223 HELRO|EnsemblGenome=HelroG153934|UniProtKB=T1ELD1 T1ELD1 20197381 PTHR18860:SF176 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON binding#GO:0005488;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624 HELRO|EnsemblGenome=HelroG122845|UniProtKB=T1EGW1 T1EGW1 20195811 PTHR14969:SF45 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;primary metabolic process#GO:0044238;lipid modification#GO:0030258;dephosphorylation#GO:0016311;lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG167047|UniProtKB=T1EYY0 T1EYY0 20201780 PTHR13581:SF5 MRG-BINDING PROTEIN MRG_MORF4L-BINDING PROTEIN regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562 HELRO|EnsemblGenome=HelroG186294|UniProtKB=T1FNX9 T1FNX9 20210526 PTHR43599:SF3 MULTIFUNCTIONAL PROTEIN ADE2 BIFUNCTIONAL PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE_PHOSPHORIBOSYLAMINOIMIDAZOLE SUCCINOCARBOXAMIDE SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;IMP metabolic process#GO:0046040;organophosphate biosynthetic process#GO:0090407;IMP biosynthetic process#GO:0006188;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;carbohydrate derivative biosynthetic process#GO:1901137;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG170154|UniProtKB=T1F2Q2 T1F2Q2 20203101 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG176119|UniProtKB=T1FA59 T1FA59 20205708 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG80833|UniProtKB=T1G461 T1G461 20215859 PTHR16515:SF88 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG76830|UniProtKB=T1G2P8 T1G2P8 20215346 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HB1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG188109|UniProtKB=T1FPN3 T1FPN3 20210780 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG64605|UniProtKB=T1FXW9 T1FXW9 20213667 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG161590|UniProtKB=T1ERN8 T1ERN8 20199238 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89107|UniProtKB=T1G788 T1G788 20216935 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG174239|UniProtKB=T1F7V0 T1F7V0 20204899 PTHR46169:SF15 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG157969|UniProtKB=T1EMI3 T1EMI3 20197783 PTHR12702:SF0 SEC15 EXOCYST COMPLEX COMPONENT 6 transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352 intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;cytoplasm#GO:0005737;exocyst#GO:0000145;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG89170|UniProtKB=T1G795 T1G795 20216942 PTHR18849:SF21 LEUCINE RICH REPEAT PROTEIN DYNEIN AXONEMAL ASSEMBLY FACTOR 11 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG81148|UniProtKB=T1G4A2 T1G4A2 20215900 PTHR11135:SF0 HISTONE ACETYLTRANSFERASE-RELATED ELONGATOR COMPLEX PROTEIN 3 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;elongator holoenzyme complex#GO:0033588 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG166133|UniProtKB=T1EXU1 T1EXU1 20201391 PTHR14618:SF0 HOMEODOX-CONTAINING PROTEIN 1 HMBOX1 HOMEOBOX-CONTAINING PROTEIN 1 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG157196|UniProtKB=T1EM78 T1EM78 20197678 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG173711|UniProtKB=T1F753 T1F753 20204652 PTHR34153:SF3 SI:CH211-262H13.3-RELATED-RELATED SI:CH211-262H13.3 HELRO|EnsemblGenome=HelroG63316|UniProtKB=T1FXE2 T1FXE2 20213490 PTHR43827:SF3 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN reductase#PC00198 HELRO|EnsemblGenome=HelroG166228|UniProtKB=T1EXX2 T1EXX2 20201422 PTHR11616:SF338 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER amino acid:sodium symporter activity#GO:0005283;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171 sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;glycine transport#GO:0015816;monoatomic cation transport#GO:0006812;localization#GO:0051179;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;monoatomic ion transport#GO:0006811;nitrogen compound transport#GO:0071705;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;establishment of localization#GO:0051234;import into cell#GO:0098657 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG88195|UniProtKB=T1G6Z7 T1G6Z7 20216844 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653 cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG145549|UniProtKB=T1EJL0 T1EJL0 20196760 PTHR13439:SF4 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN cellular component biogenesis#GO:0044085;lipid homeostasis#GO:0055088;cellular component organization#GO:0016043;membrane assembly#GO:0071709;cellular process#GO:0009987;cellular component assembly#GO:0022607;biological regulation#GO:0065007;membrane organization#GO:0061024;homeostatic process#GO:0042592;endomembrane system organization#GO:0010256;chemical homeostasis#GO:0048878;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;regulation of membrane lipid distribution#GO:0097035;regulation of biological quality#GO:0065008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169345|UniProtKB=T1F1T2 T1F1T2 20202782 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG113361|UniProtKB=T1EFR7 T1EFR7 20195419 PTHR23044:SF78 3'-5' EXONUCLEASE ERI1-RELATED 3'-5' EXONUCLEASE ERI-1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of cellular component organization#GO:0051129;rRNA processing#GO:0006364;positive regulation of biosynthetic process#GO:0009891;regulation of chromatin organization#GO:1902275;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG175903|UniProtKB=T1F9U9 T1F9U9 20205598 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67786|UniProtKB=T1FZ52 T1FZ52 20214100 PTHR45888:SF18 HL01030P-RELATED PHD FINGER PROTEIN 10 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 HELRO|EnsemblGenome=HelroG185925|UniProtKB=T1FNG1 T1FNG1 20210358 PTHR11227:SF18 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 3 phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936 cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;polysaccharide catabolic process#GO:0000272;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;intracellular protein localization#GO:0008104;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;macroautophagy#GO:0016236;glycogen catabolic process#GO:0005980;macromolecule localization#GO:0033036;localization#GO:0051179;vacuole organization#GO:0007033;organelle assembly#GO:0070925;energy reserve metabolic process#GO:0006112;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;phagophore assembly site#GO:0000407 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184292|UniProtKB=T1FKX4 T1FKX4 20209473 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191529|UniProtKB=T1FT23 T1FT23 20211970 PTHR24161:SF132 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG87652|UniProtKB=T1G6T8 T1G6T8 20216785 PTHR43461:SF1 TRANSMEMBRANE PROTEIN 256 TRANSMEMBRANE PROTEIN 256 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG194900|UniProtKB=T1FWJ6 T1FWJ6 20213191 PTHR16062:SF19 SWI/SNF-RELATED PROTEIN POLYBROMO-1 chromatin binding#GO:0003682;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 ATPase complex#GO:1904949;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;RSC-type complex#GO:0016586;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG171186|UniProtKB=T1F3W9 T1F3W9 20203518 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG83699|UniProtKB=T1G593 T1G593 20216240 PTHR24049:SF43 CRUMBS FAMILY MEMBER EGF-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG193720|UniProtKB=T1FVA5 T1FVA5 20212751 PTHR19232:SF7 CENTROCORTIN FAMILY MEMBER CENTROCORTIN, ISOFORM A HELRO|EnsemblGenome=HelroG105243|UniProtKB=T1EDS0 T1EDS0 20194722 PTHR14255:SF4 CEREBLON PROTEIN CEREBLON ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG182567|UniProtKB=T1FID1 T1FID1 20208580 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG188088|UniProtKB=T1FPM0 T1FPM0 20210767 PTHR12186:SF2 SIKE FAMILY MEMBER FGFR1 ONCOGENE PARTNER 2 HOMOLOG HELRO|EnsemblGenome=HelroG128645|UniProtKB=T1EHP7 T1EHP7 20196097 PTHR28562:SF1 COP9 SIGNALOSOME COMPLEX SUBUNIT 9 COP9 SIGNALOSOME COMPLEX SUBUNIT 9 HELRO|EnsemblGenome=HelroG185403|UniProtKB=T1FMR7 T1FMR7 20210116 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription coregulator activity#GO:0003712;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG82104|UniProtKB=T1G4M8 T1G4M8 20216026 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG99033|UniProtKB=T1G9Q6 T1G9Q6 20217802 PTHR43775:SF37 FATTY ACID SYNTHASE FATTY ACID SYNTHASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058 HELRO|EnsemblGenome=HelroG163813|UniProtKB=T1EUI1 T1EUI1 20200231 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181874|UniProtKB=T1FHF1 T1FHF1 20208250 PTHR45884:SF2 N-ACETYLTRANSFERASE ECO N-ACETYLTRANSFERASE ECO protein N-acyltransferase activity#GO:0140186;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824 mitotic sister chromatid cohesion#GO:0007064;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;chromosome organization#GO:0051276 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG99528|UniProtKB=T1G9T3 T1G9T3 20217829 PTHR46849:SF1 RCC1 DOMAIN-CONTAINING PROTEIN 1 RCC1 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG189584|UniProtKB=T1FR63 T1FR63 20211310 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG73674|UniProtKB=T1G1H2 T1G1H2 20214920 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG170531|UniProtKB=T1F360 T1F360 20203259 PTHR10476:SF1 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 3 establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;late endosome to vacuole transport#GO:0045324 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG189327|UniProtKB=T1FQY6 T1FQY6 20211233 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG160694|UniProtKB=T1EQM0 T1EQM0 20198870 PTHR15414:SF5 OS-9-RELATED PROTEIN OS-9 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;cellular localization#GO:0051641;response to unfolded protein#GO:0006986;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;macromolecule metabolic process#GO:0043170;intracellular protein localization#GO:0008104;endoplasmic reticulum unfolded protein response#GO:0030968;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to topologically incorrect protein#GO:0035967;protein metabolic process#GO:0019538;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;catabolic process#GO:0009056 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HELRO|EnsemblGenome=HelroG192902|UniProtKB=T1FUE6 T1FUE6 20212442 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED UPAR_LY6 DOMAIN-CONTAINING PROTEIN CRIM HELRO|EnsemblGenome=HelroG192382|UniProtKB=T1FTW0 T1FTW0 20212257 PTHR45623:SF14 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD1 ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;ATP-dependent activity, acting on DNA#GO:0008094;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;ATP hydrolysis activity#GO:0016887;DNA binding#GO:0003677;hydrolase activity#GO:0016787;histone binding#GO:0042393;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111 protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG67698|UniProtKB=T1FZ41 T1FZ41 20214089 PTHR11711:SF21 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6 purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;guanyl nucleotide binding#GO:0019001 protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axoneme#GO:0005930 G-protein#PC00020 HELRO|EnsemblGenome=HelroG116413|UniProtKB=T1EGE8 T1EGE8 20195650 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102 cell fate commitment#GO:0045165;system development#GO:0048731;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HELRO|EnsemblGenome=HelroG78007|UniProtKB=T1G366 T1G366 20215514 PTHR10362:SF86 HISTIDINE AMMONIA-LYASE PHENYLALANINE AMMONIA-LYASE-RELATED lyase activity#GO:0016829;catalytic activity#GO:0003824 lyase#PC00144 HELRO|EnsemblGenome=HelroG64160|UniProtKB=T1FXQ5 T1FXQ5 20213603 PTHR15241:SF304 TRANSFORMER-2-RELATED SMALL RIBOSOMAL SUBUNIT PROTEIN CS22 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG187955|UniProtKB=T1FPI2 T1FPI2 20210729 PTHR13523:SF2 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG184929|UniProtKB=T1FM63 T1FM63 20209912 PTHR13264:SF5 GCIP-INTERACTING PROTEIN P29 PRE-MRNA-SPLICING FACTOR SYF2 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG190127|UniProtKB=T1FRP9 T1FRP9 20211496 PTHR12587:SF20 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA, ISOFORM E protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynaptic active zone#GO:0048786;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194206|UniProtKB=T1FVT0 T1FVT0 20212926 PTHR23086:SF101 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 59B, ISOFORM J-RELATED lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transferase#PC00220;kinase#PC00137 HELRO|EnsemblGenome=HelroG172731|UniProtKB=T1F5V6 T1F5V6 20204205 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185715|UniProtKB=T1FN68 T1FN68 20210266 PTHR23410:SF12 RIBOSOMAL PROTEIN L5-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL18 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;positive regulation of protein metabolic process#GO:0051247;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;positive regulation of biosynthetic process#GO:0009891;protein-RNA complex assembly#GO:0022618;positive regulation of translation#GO:0045727;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;ribosomal large subunit assembly#GO:0000027;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007 intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG194170|UniProtKB=T1FVS0 T1FVS0 20212916 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168686|UniProtKB=T1F0V0 T1F0V0 20202450 PTHR31077:SF1 U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG177299|UniProtKB=T1FBH1 T1FBH1 20206170 PTHR23011:SF28 CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180721|UniProtKB=T1FG73 T1FG73 20207822 PTHR45625:SF2 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3 catalytic activity#GO:0003824;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;cis-trans isomerase activity#GO:0016859;catalytic activity, acting on a protein#GO:0140096 spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG167525|UniProtKB=T1EZG3 T1EZG3 20201963 PTHR23236:SF51 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H NUCLEOLAR PROTEIN 6 nucleic acid binding#GO:0003676;binding#GO:0005488;rRNA binding#GO:0019843;RNA binding#GO:0003723 ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185971|UniProtKB=T1FNI0 T1FNI0 20210377 PTHR45671:SF10 SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;phosphate transmembrane transporter activity#GO:0005315;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 mitochondrial carrier protein#PC00158 HELRO|EnsemblGenome=HelroG194085|UniProtKB=T1FVN5 T1FVN5 20212881 PTHR23236:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H RNA-BINDING PROTEIN 34 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG167234|UniProtKB=T1EZ59 T1EZ59 20201859 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;filopodium assembly#GO:0046847 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG140021|UniProtKB=T1EIZ8 T1EIZ8 20196548 PTHR11616:SF338 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER monoatomic cation transmembrane transporter activity#GO:0008324;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 import into cell#GO:0098657;establishment of localization#GO:0051234;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;nitrogen compound transport#GO:0071705;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;monoatomic ion transport#GO:0006811;glycine transport#GO:0015816;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;sodium ion transport#GO:0006814 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG77046|UniProtKB=T1G2S6 T1G2S6 20215374 PTHR24356:SF414 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG65586|UniProtKB=T1FYA2 T1FYA2 20213800 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176359|UniProtKB=T1FAG0 T1FAG0 20205809 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176388|UniProtKB=T1FAG9 T1FAG9 20205818 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172027|UniProtKB=T1F4Y6 T1F4Y6 20203885 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178119|UniProtKB=T1FCR9 T1FCR9 20206618 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG160629|UniProtKB=T1EQI7 T1EQI7 20198837 PTHR16112:SF16 METHYL-CPG BINDING PROTEIN, DROSOPHILA METHYL-CPG-BINDING DOMAIN PROTEIN 5_6 HOMOLOG SBA chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG183893|UniProtKB=T1FKA6 T1FKA6 20209255 PTHR44307:SF2 PHOSPHOETHANOLAMINE METHYLTRANSFERASE PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170 metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;phosphatidylcholine biosynthetic process#GO:0006656;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate biosynthetic process#GO:0090407;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG192148|UniProtKB=T1FTM7 T1FTM7 20212174 PTHR30109:SF0 HYDROXYLAMINE REDUCTASE HYDROXYLAMINE REDUCTASE oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601 response to stress#GO:0006950;cellular process#GO:0009987;response to stimulus#GO:0050896;response to chemical#GO:0042221;catabolic process#GO:0009056;metabolic process#GO:0008152;response to oxygen-containing compound#GO:1901700;response to oxidative stress#GO:0006979;response to reactive oxygen species#GO:0000302 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG189301|UniProtKB=T1FQX8 T1FQX8 20211225 PTHR13230:SF5 GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA transcription#GO:0009303;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991;transcription factor TFIIIC complex#GO:0000127 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG171767|UniProtKB=T1F4M7 T1F4M7 20203776 PTHR10334:SF565 CYSTEINE-RICH SECRETORY PROTEIN-RELATED AT04879P-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG177013|UniProtKB=T1FB52 T1FB52 20206051 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;actin binding#GO:0003779;actin filament binding#GO:0051015 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HELRO|EnsemblGenome=HelroG167340|UniProtKB=T1EZA0 T1EZA0 20201900 PTHR31180:SF2 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107 cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;cilium#GO:0005929;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;cytoplasmic microtubule#GO:0005881;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879 HELRO|EnsemblGenome=HelroG187900|UniProtKB=T1FPG5 T1FPG5 20210712 PTHR11006:SF60 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 9 histone modifying activity#GO:0140993;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182946|UniProtKB=T1FIY6 T1FIY6 20208785 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG170621|UniProtKB=T1F393 T1F393 20203292 PTHR11618:SF85 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB protein binding#GO:0005515;binding#GO:0005488;transcription factor binding#GO:0008134 protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 nucleus#GO:0005634;protein-DNA complex#GO:0032993;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 General transcription regulation#P00023>TFIIB#P00668;Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397 HELRO|EnsemblGenome=HelroG162308|UniProtKB=T1ESH7 T1ESH7 20199527 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG185603|UniProtKB=T1FN10 T1FN10 20210209 PTHR11034:SF62 N-MYC DOWNSTREAM REGULATED GH09802P cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG186052|UniProtKB=T1FNL7 T1FNL7 20210414 PTHR35841:SF1 PHOSPHONATES-BINDING PERIPLASMIC PROTEIN PHOSPHATE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN HELRO|EnsemblGenome=HelroG194836|UniProtKB=T1FWG9 T1FWG9 20213164 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114796|UniProtKB=T1EG45 T1EG45 20195547 PTHR14289:SF16 F-BOX ONLY PROTEIN 3 POLYMERASE DELTA-INTERACTING PROTEIN 2 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA synthesis involved in DNA replication#GO:0090592 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;mitochondrial nucleoid#GO:0042645;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;nucleoid#GO:0009295;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG115219|UniProtKB=T1EG73 T1EG73 20195575 PTHR11254:SF395 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SMURF1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;negative regulation of BMP signaling pathway#GO:0030514;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>LACK#P06230;DPP signaling pathway#P06213>LACK#P06278;GBB signaling pathway#P06214>LACK#P06303;MYO signaling pathway#P06215>LACK#P06309;TGF-beta signaling pathway#P00052>Smurfs#P01279;ALP23B signaling pathway#P06209>LACK#P06219;SCW signaling pathway#P06216>LACK#P06321;BMP/activin signaling pathway-drosophila#P06211>Smurf#P06243;DPP-SCW signaling pathway#P06212>LACK#P06269 HELRO|EnsemblGenome=HelroG82872|UniProtKB=T1G4X7 T1G4X7 20216125 PTHR31409:SF0 WASH COMPLEX SUBUNIT 4 WASH COMPLEX SUBUNIT 4 intracellular transport#GO:0046907;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG162309|UniProtKB=T1ESH8 T1ESH8 20199528 PTHR12109:SF3 RING FINGER PROTEIN 141-RELATED RING FINGER PROTEIN 141 aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG153303|UniProtKB=T1EL28 T1EL28 20197278 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175127|UniProtKB=T1F8W2 T1F8W2 20205261 PTHR23149:SF9 G PATCH DOMAIN CONTAINING PROTEIN G PATCH DOMAIN-CONTAINING PROTEIN 4 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG152794|UniProtKB=T1EKX0 T1EKX0 20197220 PTHR19359:SF14 CYTOCHROME B5 CYTOCHROME B5 tetrapyrrole binding#GO:0046906;binding#GO:0005488;heme binding#GO:0020037 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;membrane#GO:0016020 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185211|UniProtKB=T1FMI5 T1FMI5 20210034 PTHR43943:SF19 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE 4 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG62270|UniProtKB=T1FWY2 T1FWY2 20213330 PTHR11607:SF72 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;lysosome#GO:0005764;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 hydrolase#PC00121;glycosidase#PC00110 HELRO|EnsemblGenome=HelroG96112|UniProtKB=T1G9A3 T1G9A3 20217650 PTHR46355:SF1 UPF0428 PROTEIN CXORF56 STING ER EXIT PROTEIN endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;endoplasmic reticulum membrane organization#GO:0090158;intracellular transport#GO:0046907 HELRO|EnsemblGenome=HelroG174160|UniProtKB=T1F7P7 T1F7P7 20204846 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163710|UniProtKB=T1EUD9 T1EUD9 20200189 PTHR13255:SF1 ATAXIN-10 ATAXIN-10 cilium organization#GO:0044782;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cilium assembly#GO:0060271;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996 dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG156707|UniProtKB=T1EM01 T1EM01 20197601 PTHR12356:SF18 NUCLEAR MOVEMENT PROTEIN NUDC NUDC DOMAIN-CONTAINING PROTEIN 2 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG77767|UniProtKB=T1G336 T1G336 20215484 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG177907|UniProtKB=T1FCG4 T1FCG4 20206513 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG63644|UniProtKB=T1FXI6 T1FXI6 20213534 PTHR31219:SF2 CHROMOSOME 28 C12ORF29 HOMOLOG RNA LIGASE 1 HELRO|EnsemblGenome=HelroG87723|UniProtKB=T1G6U8 T1G6U8 20216795 PTHR23248:SF63 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;intramembrane lipid carrier activity#GO:0140303 macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid transport#GO:0015914;endomembrane system organization#GO:0010256;phospholipid translocation#GO:0045332;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;lipid localization#GO:0010876;localization#GO:0051179;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG69200|UniProtKB=T1FZQ9 T1FZQ9 20214307 PTHR10969:SF101 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED 63 KDA SPERM FLAGELLAR MEMBRANE PROTEIN ubiquitin protein ligase binding#GO:0031625;lipid binding#GO:0008289;protein binding#GO:0005515;enzyme binding#GO:0019899;phospholipid binding#GO:0005543;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488 response to stimulus#GO:0050896;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;cellular component organization#GO:0016043;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to nutrient levels#GO:0031667;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352;cellular response to starvation#GO:0009267;metabolic process#GO:0008152;cellular response to nutrient levels#GO:0031669 vacuolar membrane#GO:0005774;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;autophagosome#GO:0005776;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG109006|UniProtKB=T1EEP9 T1EEP9 20195051 PTHR21422:SF9 RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of metabolic process#GO:0019222;positive regulation of autophagy#GO:0010508;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of macroautophagy#GO:0016241;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;positive regulation of macroautophagy#GO:0016239;regulation of autophagosome assembly#GO:2000785;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;positive regulation of metabolic process#GO:0009893 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG177672|UniProtKB=T1FC19 T1FC19 20206368 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG170575|UniProtKB=T1F372 T1F372 20203271 PTHR14948:SF25 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166201|UniProtKB=T1EXW5 T1EXW5 20201415 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE GLYCOPROTEIN 3-ALPHA-L-FUCOSYLTRANSFERASE A catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;alpha-(1->3)-fucosyltransferase activity#GO:0046920 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG70306|UniProtKB=T1G043 T1G043 20214441 PTHR12166:SF8 CALCIUM-DEPENDENT SECRETION ACTIVATOR CALCIUM-DEPENDENT SECRETION ACTIVATOR vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG106233|UniProtKB=T1EE10 T1EE10 20194812 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG175767|UniProtKB=T1F9M5 T1F9M5 20205524 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG179371|UniProtKB=T1FEM2 T1FEM2 20207271 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG182051|UniProtKB=T1FHN5 T1FHN5 20208334 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66647|UniProtKB=T1FYN5 T1FYN5 20213933 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity#GO:0003824 catabolic process#GO:0009056;sulfur compound catabolic process#GO:0044273;cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183439|UniProtKB=T1FJN5 T1FJN5 20209034 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110137|UniProtKB=T1EEZ7 T1EEZ7 20195149 PTHR24416:SF647 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cell migration#GO:0016477;biological regulation#GO:0065007;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173407|UniProtKB=T1F6S3 T1F6S3 20204522 PTHR38537:SF8 JITTERBUG, ISOFORM N CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176455|UniProtKB=T1FAI9 T1FAI9 20205838 PTHR48625:SF2 C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG181288|UniProtKB=T1FGU7 T1FGU7 20208046 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113444|UniProtKB=T1EFS5 T1EFS5 20195427 PTHR45922:SF2 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG162962|UniProtKB=T1ETF7 T1ETF7 20199857 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69219|UniProtKB=T1FZR2 T1FZR2 20214310 PTHR11575:SF48 5'-NUCLEOTIDASE-RELATED ECTO-5'-NUCLEOTIDASE cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG170239|UniProtKB=T1F2T5 T1F2T5 20203134 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG174600|UniProtKB=T1F8A6 T1F8A6 20205055 PTHR11214:SF411 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG182426|UniProtKB=T1FI64 T1FI64 20208513 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66762|UniProtKB=T1FYQ5 T1FYQ5 20213953 PTHR47977:SF90 RAS-RELATED PROTEIN RAB RAS AND EF-HAND DOMAIN-CONTAINING PROTEIN HOMOLOG hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553 cellular process#GO:0009987;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG107172|UniProtKB=T1EE84 T1EE84 20194886 PTHR12944:SF2 SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE binding#GO:0005488;nucleic acid binding#GO:0003676;tRNA binding#GO:0000049;RNA binding#GO:0003723 regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;protein biosynthetic process#GO:0160307;regulation of cellular process#GO:0050794;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;biosynthetic process#GO:0009058;gene expression#GO:0010467;translational elongation#GO:0006414;metabolic process#GO:0008152;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889 HELRO|EnsemblGenome=HelroG191354|UniProtKB=T1FSX0 T1FSX0 20211917 PTHR12429:SF6 NEURALIZED PROTEIN NEURALIZED catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 endocytosis#GO:0006897;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;localization#GO:0051179;protein transport#GO:0015031;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular protein localization#GO:0008104;regulation of response to stimulus#GO:0048583;transport#GO:0006810 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191626|UniProtKB=T1FT53 T1FT53 20212000 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG160014|UniProtKB=T1EPN7 T1EPN7 20198537 PTHR35193:SF5 MUCIN 13A, CELL SURFACE-ASSOCIATED-RELATED SEA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177167|UniProtKB=T1FBB0 T1FBB0 20206109 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN anatomical structure development#GO:0048856;developmental process#GO:0032502 HELRO|EnsemblGenome=HelroG85113|UniProtKB=T1G5T0 T1G5T0 20216427 PTHR48043:SF168 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG95842|UniProtKB=T1G982 T1G982 20217629 PTHR11953:SF0 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT RRP41 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;macromolecule catabolic process#GO:0009057;RNA catabolic process#GO:0006401;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188219|UniProtKB=T1FPS4 T1FPS4 20210821 PTHR12801:SF158 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED RNA EXONUCLEASE 4 hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA catabolic process#GO:0006308;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179591|UniProtKB=T1FEX0 T1FEX0 20207369 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG94807|UniProtKB=T1G931 T1G931 20217578 PTHR15852:SF54 PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN PROTEIN SSUH2 HOMOLOG HELRO|EnsemblGenome=HelroG194280|UniProtKB=T1FVW2 T1FVW2 20212958 PTHR16071:SF2 CHROMOSOME 1 OPEN READING FRAME 112 FIGNL1-INTERACTING REGULATOR OF RECOMBINATION AND MITOSIS HELRO|EnsemblGenome=HelroG180283|UniProtKB=T1FFP2 T1FFP2 20207641 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG191961|UniProtKB=T1FTG4 T1FTG4 20212111 PTHR10742:SF425 FLAVIN MONOAMINE OXIDASE AMINE OXIDASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidase#PC00175 HELRO|EnsemblGenome=HelroG168011|UniProtKB=T1F023 T1F023 20202173 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159038|UniProtKB=T1ENI4 T1ENI4 20198134 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG90179|UniProtKB=T1G7L9 T1G7L9 20217066 PTHR10173:SF52 METHIONINE SULFOXIDE REDUCTASE METHIONINE-R-SULFOXIDE REDUCTASE B1 oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 reductase#PC00198;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG129652|UniProtKB=T1EHS0 T1EHS0 20196120 PTHR45134:SF5 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63244|UniProtKB=T1FXC9 T1FXC9 20213477 PTHR22883:SF147 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 protein targeting#GO:0006605;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166344|UniProtKB=T1EY15 T1EY15 20201465 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HELRO|EnsemblGenome=HelroG194810|UniProtKB=T1FWF7 T1FWF7 20213152 PTHR13723:SF313 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 external encapsulating structure organization#GO:0045229;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG155886|UniProtKB=T1ELN7 T1ELN7 20197487 PTHR24006:SF823 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG156400|UniProtKB=T1ELV6 T1ELV6 20197556 PTHR10529:SF377 AP COMPLEX SUBUNIT MU ADAPTOR PROTEIN COMPLEX 2, MU SUBUNIT, ISOFORM A cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892 clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;coated membrane#GO:0048475;endocytic vesicle#GO:0030139;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytosol#GO:0005829;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177306|UniProtKB=T1FBH3 T1FBH3 20206172 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG82857|UniProtKB=T1G4X5 T1G4X5 20216123 PTHR13914:SF0 PROLINE OXIDASE PROLINE DEHYDROGENASE-RELATED nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;small molecule binding#GO:0036094 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidase#PC00175 Huntington disease#P00029>Proline oxidase#G01529 HELRO|EnsemblGenome=HelroG172613|UniProtKB=T1F5M6 T1F5M6 20204125 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808 plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell leading edge#GO:0031252;cell projection membrane#GO:0031253;neuron projection membrane#GO:0032589;leading edge membrane#GO:0031256 HELRO|EnsemblGenome=HelroG109256|UniProtKB=T1EES0 T1EES0 20195072 PTHR11469:SF1 GLUCOSE-6-PHOSPHATE ISOMERASE GLUCOSE-6-PHOSPHATE ISOMERASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;intramolecular oxidoreductase activity#GO:0016860;carbohydrate binding#GO:0030246;isomerase activity#GO:0016853;monosaccharide binding#GO:0048029;small molecule binding#GO:0036094;binding#GO:0005488 metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;gluconeogenesis#GO:0006094;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;ribonucleoside diphosphate metabolic process#GO:0009185;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;nucleotide catabolic process#GO:0009166;small molecule biosynthetic process#GO:0044283;energy derivation by oxidation of organic compounds#GO:0015980;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;nucleoside diphosphate catabolic process#GO:0009134;glucose 6-phosphate metabolic process#GO:0051156;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;ADP catabolic process#GO:0046032;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate biosynthetic process#GO:0016051;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;monocarboxylic acid metabolic process#GO:0032787;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;pyruvate metabolic process#GO:0006090;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;isomerase#PC00135 Pentose phosphate pathway#P02762>Glucose-P-Isomerase#P03080;Glycolysis#P00024>Phosphoglucose isomerase#P00674 HELRO|EnsemblGenome=HelroG172549|UniProtKB=T1F5I0 T1F5I0 20204079 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72267|UniProtKB=T1G0X8 T1G0X8 20214726 PTHR24031:SF790 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179568|UniProtKB=T1FEV9 T1FEV9 20207358 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG172768|UniProtKB=T1F5X0 T1F5X0 20204219 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG184100|UniProtKB=T1FKK7 T1FKK7 20209356 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182236|UniProtKB=T1FHZ1 T1FHZ1 20208440 PTHR24193:SF126 ANKYRIN REPEAT PROTEIN INVERSIN-LIKE DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG167266|UniProtKB=T1EZ70 T1EZ70 20201870 PTHR12534:SF0 30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR SMALL RIBOSOMAL SUBUNIT PROTEIN US2M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG66765|UniProtKB=T1FYQ6 T1FYQ6 20213954 PTHR24348:SF79 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED AUTOPHAGY-RELATED 1, ISOFORM B phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;process utilizing autophagic mechanism#GO:0061919;neuron projection extension#GO:1990138;developmental growth involved in morphogenesis#GO:0060560;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;regulation of autophagy#GO:0010506;cell development#GO:0048468;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;cell projection morphogenesis#GO:0048858;cell growth#GO:0016049;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;response to stress#GO:0006950;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;axon extension#GO:0048675;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;vacuole organization#GO:0007033;system development#GO:0048731;anatomical structure development#GO:0048856;response to starvation#GO:0042594;developmental cell growth#GO:0048588;piecemeal microautophagy of the nucleus#GO:0034727;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;autophagy of mitochondrion#GO:0000422;regulation of catabolic process#GO:0009894;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental growth#GO:0048589;mitophagy#GO:0000423;reticulophagy#GO:0061709;regulation of metabolic process#GO:0019222;axon development#GO:0061564;response to nutrient levels#GO:0031667;macroautophagy#GO:0016236;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG156866|UniProtKB=T1EM22 T1EM22 20197622 PTHR10870:SF0 CELL CYCLE CHECKPOINT PROTEIN RAD1 CELL CYCLE CHECKPOINT PROTEIN RAD1 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 negative regulation of cell cycle#GO:0045786;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA integrity checkpoint signaling#GO:0031570;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 exodeoxyribonuclease#PC00098;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG176791|UniProtKB=T1FAX0 T1FAX0 20205969 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4 INTERACTING CHROMATIN REMODELING COMPLEX ASSOCIATED PROTEIN, ISOFORM B regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG68226|UniProtKB=T1FZB8 T1FZB8 20214166 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 6 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG178296|UniProtKB=T1FD20 T1FD20 20206719 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;localization#GO:0051179;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of establishment or maintenance of cell polarity#GO:0032878 intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG64915|UniProtKB=T1FY12 T1FY12 20213710 PTHR22997:SF12 PIH1 DOMAIN-CONTAINING PROTEIN 1 LD09868P-RELATED cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG184218|UniProtKB=T1FKS6 T1FKS6 20209425 PTHR10333:SF114 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 3 histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone H3 reader activity#GO:0140006;chromatin-protein adaptor activity#GO:0140463 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;NuA4 histone acetyltransferase complex#GO:0035267;nucleus#GO:0005634;chromatin#GO:0000785;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG190994|UniProtKB=T1FSH4 T1FSH4 20211771 PTHR46394:SF1 ANNEXIN PNPLA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69644|UniProtKB=T1FZX7 T1FZX7 20214375 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181687|UniProtKB=T1FH85 T1FH85 20208184 PTHR24088:SF0 28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN US17M organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG194657|UniProtKB=T1FWA3 T1FWA3 20213099 PTHR10231:SF106 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-GALACTOSE TRANSLOCATOR transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;UDP-galactose transmembrane transporter activity#GO:0005459;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nucleotide-sugar transmembrane transport#GO:0015780;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG184988|UniProtKB=T1FM84 T1FM84 20209933 PTHR10678:SF3 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 COP9 SIGNALOSOME COMPLEX SUBUNIT 2 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157124|UniProtKB=T1EM66 T1EM66 20197666 PTHR11661:SF2 60S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN UL11 structural molecule activity#GO:0005198;RNA binding#GO:0003723;binding#GO:0005488;structural constituent of ribosome#GO:0003735;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG62623|UniProtKB=T1FX28 T1FX28 20213376 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity#GO:0016740 glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 transferase#PC00220 HELRO|EnsemblGenome=HelroG187038|UniProtKB=T1FP58 T1FP58 20210605 PTHR11915:SF455 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ, SARCOMERIC-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;cellular component organization#GO:0016043 cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane#GO:0016020;Z disc#GO:0030018;cell periphery#GO:0071944;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;I band#GO:0031674;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HELRO|EnsemblGenome=HelroG108727|UniProtKB=T1EEL9 T1EEL9 20195021 PTHR22901:SF0 SIALATE O-ACETYLESTERASE SIALATE O-ACETYLESTERASE catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 carbohydrate metabolic process#GO:0005975;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG107257|UniProtKB=T1EE91 T1EE91 20194893 PTHR24393:SF34 ZINC FINGER PROTEIN ZINC FINGER PROTEIN ZFP-2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG190084|UniProtKB=T1FRN9 T1FRN9 20211486 PTHR48021:SF1 FAMILY NOT NAMED MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG66736|UniProtKB=T1FYQ0 T1FYQ0 20213948 PTHR47651:SF17 NAD-DEPENDENT HISTONE DEACETYLASE HST4 DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG83644|UniProtKB=T1G586 T1G586 20216233 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG188305|UniProtKB=T1FPU7 T1FPU7 20210844 PTHR21119:SF5 C2 DOMAIN-CONTAINING PROTEIN C2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173147|UniProtKB=T1F6G3 T1F6G3 20204412 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 endonuclease activity#GO:0004519;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;3'-5' exonuclease activity#GO:0008408;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;phosphoric ester hydrolase activity#GO:0042578;DNA exonuclease activity#GO:0004529;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;DNA endonuclease activity#GO:0004520;exonuclease activity#GO:0004527 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG74247|UniProtKB=T1G1N8 T1G1N8 20214986 PTHR11749:SF3 RIBULOSE-5-PHOSPHATE-3-EPIMERASE RIBULOSE-PHOSPHATE 3-EPIMERASE binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;D-ribulose-phosphate 3-epimerase activity#GO:0004750;metal ion binding#GO:0046872;cation binding#GO:0043169;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;racemase and epimerase activity#GO:0016854;isomerase activity#GO:0016853 pentose-phosphate shunt#GO:0006098;glyceraldehyde-3-phosphate metabolic process#GO:0019682;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;nucleotide metabolic process#GO:0009117;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;pentose-phosphate shunt, non-oxidative branch#GO:0009052;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Ascorbate degradation#P02729>L-xylulose-5-phosphate-3-epimerase#P02852 HELRO|EnsemblGenome=HelroG191035|UniProtKB=T1FSI9 T1FSI9 20211786 PTHR24416:SF527 TYROSINE-PROTEIN KINASE RECEPTOR PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of signaling#GO:0023051;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163239|UniProtKB=T1ETT8 T1ETT8 20199988 PTHR13866:SF14 SPARC OSTEONECTIN BM-40 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG193409|UniProtKB=T1FUY8 T1FUY8 20212634 PTHR13503:SF3 NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B NEGATIVE ELONGATION FACTOR B negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;stem cell differentiation#GO:0048863;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG174453|UniProtKB=T1F851 T1F851 20205000 PTHR12425:SF5 SYNEMBRYN CHAPERONE RIC-8 binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;enzyme regulator activity#GO:0030234 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG147374|UniProtKB=T1EJZ6 T1EJZ6 20196896 PTHR11849:SF289 ETS ETS-LIKE PROTEIN POINTED DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG189800|UniProtKB=T1FRD5 T1FRD5 20211382 PTHR24113:SF12 RAN GTPASE-ACTIVATING PROTEIN 1 RAN GTPASE-ACTIVATING PROTEIN 1 molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 transport#GO:0006810;nucleocytoplasmic transport#GO:0006913;intracellular transport#GO:0046907;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cytosol#GO:0005829;nucleus#GO:0005634 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG164106|UniProtKB=T1EUX6 T1EUX6 20200376 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG64830|UniProtKB=T1FY00 T1FY00 20213698 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179328|UniProtKB=T1FEK1 T1FEK1 20207250 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG87016|UniProtKB=T1G6K6 T1G6K6 20216703 PTHR23289:SF2 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HEME A SYNTHASE COX15 chaperone#PC00072 Vitamin D metabolism and pathway#P04396>FDX#P04607 HELRO|EnsemblGenome=HelroG163577|UniProtKB=T1EU86 T1EU86 20200136 PTHR33244:SF8 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189225|UniProtKB=T1FQT8 T1FQT8 20211185 PTHR14150:SF12 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 UTP14A SMALL SUBUNIT PROCESSOME COMPONENT molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178410|UniProtKB=T1FD48 T1FD48 20206747 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 nuclear receptor binding#GO:0016922;binding#GO:0005488;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG117069|UniProtKB=T1EGJ9 T1EGJ9 20213286 PTHR12538:SF0 40S RIBOSOMAL PROTEIN S26 40S RIBOSOMAL PROTEIN S26 structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;structural molecule activity#GO:0005198 small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG159107|UniProtKB=T1ENL6 T1ENL6 20198166 PTHR45695:SF9 LEUCOKININ RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181949|UniProtKB=T1FHH8 T1FHH8 20208277 PTHR13720:SF33 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG80977|UniProtKB=T1G478 T1G478 20215876 PTHR11618:SF85 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB transcription factor binding#GO:0008134;binding#GO:0005488;protein binding#GO:0005515 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nucleus#GO:0005634;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 General transcription regulation#P00023>TFIIB#P00668;Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397 HELRO|EnsemblGenome=HelroG184827|UniProtKB=T1FM21 T1FM21 20209870 PTHR11040:SF211 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP11 transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324 metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG168432|UniProtKB=T1F0L2 T1F0L2 20202362 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG164074|UniProtKB=T1EUV9 T1EUV9 20200359 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161686|UniProtKB=T1ERS6 T1ERS6 20199276 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG135743|UniProtKB=T1EIA3 T1EIA3 20196303 PTHR10252:SF163 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 gene expression#GO:0010467;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG177173|UniProtKB=T1FBB4 T1FBB4 20206113 PTHR47246:SF1 MUCIN-19 MUCIN-19 HELRO|EnsemblGenome=HelroG172621|UniProtKB=T1F5N2 T1F5N2 20204131 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193897|UniProtKB=T1FVG5 T1FVG5 20212811 PTHR13236:SF0 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2 CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1 binding#GO:0005488;protein binding#GO:0005515 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;intraciliary transport involved in cilium assembly#GO:0035735;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925 protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;dynein complex#GO:0030286;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG182211|UniProtKB=T1FHX7 T1FHX7 20208426 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG182100|UniProtKB=T1FHR1 T1FHR1 20208360 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92025|UniProtKB=T1G8B4 T1G8B4 20217311 PTHR15722:SF7 IFT140/172-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG intracellular transport#GO:0046907;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;cilium organization#GO:0044782;cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;cell projection organization#GO:0030030;intraciliary transport#GO:0042073 ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;intraciliary transport particle A#GO:0030991;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intraciliary transport particle#GO:0030990;cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 structural protein#PC00211 HELRO|EnsemblGenome=HelroG82314|UniProtKB=T1G4Q6 T1G4Q6 20216054 PTHR10891:SF989 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG90450|UniProtKB=T1G7R5 T1G7R5 20217112 PTHR39948:SF1 GEO11419P1 GEO11419P1 HELRO|EnsemblGenome=HelroG178476|UniProtKB=T1FD83 T1FD83 20206782 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG174796|UniProtKB=T1F8H4 T1F8H4 20205123 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG72081|UniProtKB=T1G0V2 T1G0V2 20214700 PTHR43827:SF13 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN reductase#PC00198 HELRO|EnsemblGenome=HelroG189267|UniProtKB=T1FQW2 T1FQW2 20211209 PTHR43173:SF19 ABC1 FAMILY PROTEIN AARF DOMAIN-CONTAINING PROTEIN KINASE 1 cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;mitochondrion organization#GO:0007005;cellular process#GO:0009987;cellular component organization#GO:0016043;lipid homeostasis#GO:0055088;organelle organization#GO:0006996 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG159436|UniProtKB=T1EP12 T1EP12 20198312 PTHR15907:SF161 DUF614 FAMILY PROTEIN-RELATED DUF614 DOMAIN PROTEIN HELRO|EnsemblGenome=HelroG173108|UniProtKB=T1F6D2 T1F6D2 20204381 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99285|UniProtKB=T1G9R9 T1G9R9 20217815 PTHR10010:SF46 SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG188063|UniProtKB=T1FPL3 T1FPL3 20210760 PTHR17695:SF11 SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730 HELRO|EnsemblGenome=HelroG169234|UniProtKB=T1F1L9 T1F1L9 20202719 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG162142|UniProtKB=T1ESA2 T1ESA2 20199452 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;mitochondrial DNA metabolic process#GO:0032042;DNA-templated DNA replication#GO:0006261;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG83409|UniProtKB=T1G552 T1G552 20216200 PTHR24346:SF114 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG184201|UniProtKB=T1FKR3 T1FKR3 20209412 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172219|UniProtKB=T1F555 T1F555 20203954 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to stimulus#GO:0050896;response to stress#GO:0006950;response to starvation#GO:0042594;response to nutrient levels#GO:0031667 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG193936|UniProtKB=T1FVH6 T1FVH6 20212822 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773 purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 kinase#PC00137;metabolite interconversion enzyme#PC00262 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG66818|UniProtKB=T1FYR4 T1FYR4 20213962 PTHR24210:SF0 LIM DOMAIN-CONTAINING PROTEIN LIM DOMAIN-CONTAINING PROTEIN positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;cell adhesion#GO:0007155;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of signal transduction#GO:0009967;cellular component organization or biogenesis#GO:0071840;regulation of response to stimulus#GO:0048583;cell-cell junction organization#GO:0045216;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell-cell adhesion#GO:0098609 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 cell junction protein#PC00070 Integrin signalling pathway#P00034>PINCH#P00921 HELRO|EnsemblGenome=HelroG181782|UniProtKB=T1FHB4 T1FHB4 20208213 PTHR48012:SF18 STERILE20-LIKE KINASE, ISOFORM B-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>GCKR#P00311;Apoptosis signaling pathway#P00006>GCK#P00268 HELRO|EnsemblGenome=HelroG66255|UniProtKB=T1FYI7 T1FYI7 20213885 PTHR10640:SF7 METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;carbohydrate derivative metabolic process#GO:1901135;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;purine-containing compound metabolic process#GO:0072521;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG86572|UniProtKB=T1G6E1 T1G6E1 20216638 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG95007|UniProtKB=T1G941 T1G941 20217588 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG190369|UniProtKB=T1FRX8 T1FRX8 20211575 PTHR24249:SF422 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG84106|UniProtKB=T1G5E9 T1G5E9 20216296 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;signaling#GO:0023052;cellular response to radiation#GO:0071478;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;biological regulation#GO:0065007;detection of stimulus#GO:0051606;signal transduction#GO:0007165;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987;response to radiation#GO:0009314 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG64769|UniProtKB=T1FXY8 T1FXY8 20213686 PTHR24356:SF240 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 non-receptor serine/threonine protein kinase#PC00167 VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;EGF receptor signaling pathway#P00018>PKC#P00565;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;Apoptosis signaling pathway#P00006>PKCs#P00318;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;FGF signaling pathway#P00021>PKC#P00648;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Endothelin signaling pathway#P00019>PKC#P00568 HELRO|EnsemblGenome=HelroG184444|UniProtKB=T1FL78 T1FL78 20209577 PTHR33865:SF3 PROTEIN FAM183B CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 144 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;ciliary base#GO:0097546 HELRO|EnsemblGenome=HelroG112400|UniProtKB=T1EFJ6 T1EFJ6 20195348 PTHR12860:SF0 SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68 ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;cellular localization#GO:0051641;protein targeting to ER#GO:0045047;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein targeting#GO:0006605;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987 signal recognition particle, endoplasmic reticulum targeting#GO:0005786;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG145957|UniProtKB=T1EJP3 T1EJP3 20196793 PTHR22883:SF507 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN ZDHHC-TYPE PALMITOYLTRANSFERASE 7-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;protein targeting#GO:0006605;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG103762|UniProtKB=T1EDH3 T1EDH3 20194625 PTHR12509:SF8 SPERMATOGENESIS-ASSOCIATED 4-RELATED SPERMATOGENESIS-ASSOCIATED PROTEIN 4 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG176772|UniProtKB=T1FAW5 T1FAW5 20205964 PTHR45765:SF1 METHIONINE--TRNA LIGASE METHIONINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;cytosol#GO:0005829 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG106578|UniProtKB=T1EE35 T1EE35 20194837 PTHR48083:SF35 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED ACYL-COA DEHYDROGENASE FAMILY MEMBER 10 oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG161341|UniProtKB=T1ERD1 T1ERD1 20199131 PTHR24073:SF1242 DRAB5-RELATED RAS-RELATED PROTEIN RAB-18 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;lipid droplet organization#GO:0034389;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG112211|UniProtKB=T1EFH8 T1EFH8 20195330 PTHR24343:SF576 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of signal transduction#GO:0009968;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;negative regulation of TORC1 signaling#GO:1904262;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;localization#GO:0051179;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;positive regulation of cellular process#GO:0048522;cellular response to glucose starvation#GO:0042149;macromolecule localization#GO:0033036;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;intracellular protein localization#GO:0008104;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107827|UniProtKB=T1EED0 T1EED0 20194932 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 postsynaptic membrane#GO:0045211;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG178210|UniProtKB=T1FCY1 T1FCY1 20206680 PTHR33244:SF8 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75645|UniProtKB=T1G282 T1G282 20215180 PTHR11575:SF50 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine ribonucleotide catabolic process#GO:0009154;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;purine nucleotide catabolic process#GO:0006195;ribonucleotide metabolic process#GO:0009259;nucleobase-containing compound metabolic process#GO:0006139;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;purine ribonucleotide metabolic process#GO:0009150;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG194975|UniProtKB=T1FWM2 T1FWM2 20213217 PTHR38709:SF1 SI:CH73-193C12.2-RELATED C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN-RELATED cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG96415|UniProtKB=T1G9B9 T1G9B9 20217666 PTHR15696:SF5 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7 telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG62273|UniProtKB=T1FWY3 T1FWY3 20213331 PTHR10807:SF75 MYOTUBULARIN-RELATED LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;protein phosphatase binding#GO:0019903;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;phosphoric ester hydrolase activity#GO:0042578;enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787 phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;dephosphorylation#GO:0016311;lipid modification#GO:0030258;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644 membrane#GO:0016020;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG183642|UniProtKB=T1FJZ3 T1FJZ3 20209142 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG77130|UniProtKB=T1G2T5 T1G2T5 20215383 PTHR11347:SF198 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE, ISOFORM I phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG97407|UniProtKB=T1G9G6 T1G9G6 20217713 PTHR11347:SF209 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 cyclic nucleotide metabolic process#GO:0009187;regulation of response to stimulus#GO:0048583;nucleotide catabolic process#GO:0009166;negative regulation of cellular process#GO:0048523;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of response to stimulus#GO:0048585;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;regulation of cellular process#GO:0050794;cyclic purine nucleotide metabolic process#GO:0052652;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;negative regulation of signal transduction#GO:0009968;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;ribonucleotide metabolic process#GO:0009259;negative regulation of cell communication#GO:0010648;nucleotide metabolic process#GO:0009117;negative regulation of intracellular signal transduction#GO:1902532;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;negative regulation of biological process#GO:0048519;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG159271|UniProtKB=T1ENT3 T1ENT3 20198233 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG159762|UniProtKB=T1EPD6 T1EPD6 20198436 PTHR46004:SF3 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HELRO|EnsemblGenome=HelroG156937|UniProtKB=T1EM36 T1EM36 20197636 PTHR23235:SF189 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG111042|UniProtKB=T1EF74 T1EF74 20195226 PTHR11759:SF1 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 SMALL RIBOSOMAL SUBUNIT PROTEIN US11 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 organelle assembly#GO:0070925;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;ribosomal small subunit assembly#GO:0000028;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG193539|UniProtKB=T1FV38 T1FV38 20212684 PTHR24103:SF557 E3 UBIQUITIN-PROTEIN LIGASE TRIM RING-TYPE DOMAIN-CONTAINING PROTEIN immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85197|UniProtKB=T1G5U2 T1G5U2 20216439 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG180945|UniProtKB=T1FGG3 T1FGG3 20207912 PTHR13044:SF14 ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 CRYPTOCEPHAL, ISOFORM A DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG185094|UniProtKB=T1FME0 T1FME0 20209989 PTHR13050:SF7 USE1-LIKE PROTEIN VESICLE TRANSPORT PROTEIN USE1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG189103|UniProtKB=T1FQN5 T1FQN5 20211132 PTHR24118:SF103 POTE ANKYRIN DOMAIN REPEAT PROTEIN, PUTATIVE-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191032|UniProtKB=T1FSI7 T1FSI7 20211784 PTHR12898:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription initiation#GO:2000142;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252 nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG183077|UniProtKB=T1FJ49 T1FJ49 20208848 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG170016|UniProtKB=T1F2J2 T1F2J2 20203042 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114081|UniProtKB=T1EFY9 T1EFY9 20195491 PTHR11042:SF91 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG76233|UniProtKB=T1G2H0 T1G2H0 20215268 PTHR22977:SF1 COX ASSEMBLY MITOCHONDRIAL PROTEIN COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG98406|UniProtKB=T1G9M4 T1G9M4 20217770 PTHR11692:SF0 BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;IMP metabolic process#GO:0046040;organophosphate biosynthetic process#GO:0090407;IMP biosynthetic process#GO:0006188;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 De novo purine biosynthesis#P02738>AICAR transformylase#P02900;De novo purine biosynthesis#P02738>IMP cyclohydrolase#P02894 HELRO|EnsemblGenome=HelroG175877|UniProtKB=T1F9T5 T1F9T5 20205584 PTHR47577:SF4 THAP DOMAIN-CONTAINING PROTEIN 6 TRANSPOSABLE ELEMENT P TRANSPOSASE-LIKE RNASE H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94914|UniProtKB=T1G938 T1G938 20217585 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED FI18012P1 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG105842|UniProtKB=T1EDX9 T1EDX9 20194781 PTHR24198:SF204 ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN SERINE_THREONINE-PROTEIN KINASE 33-RELATED cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG162659|UniProtKB=T1ESZ3 T1ESZ3 20199693 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189871|UniProtKB=T1FRF6 T1FRF6 20211403 PTHR13032:SF6 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;protein localization to mitochondrion#GO:0070585;protein transport#GO:0015031;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907 mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG172407|UniProtKB=T1F5A1 T1F5A1 20204000 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG133636|UniProtKB=T1EI19 T1EI19 20196219 PTHR24416:SF647 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;cell migration#GO:0016477;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77058|UniProtKB=T1G2S8 T1G2S8 20215376 PTHR11800:SF13 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG174795|UniProtKB=T1F8H3 T1F8H3 20205122 PTHR35076:SF1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 HELRO|EnsemblGenome=HelroG168721|UniProtKB=T1F0W2 T1F0W2 20202462 PTHR31882:SF11 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER HDA1 COMPLEX SUBUNIT 2 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 HELRO|EnsemblGenome=HelroG193946|UniProtKB=T1FVI3 T1FVI3 20212829 PTHR10120:SF24 CAAX PRENYL PROTEASE 1 CAAX PRENYL PROTEASE 1 HOMOLOG metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG169458|UniProtKB=T1F1Y8 T1F1Y8 20202838 PTHR22763:SF192 RING ZINC FINGER PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG180872|UniProtKB=T1FGC8 T1FGC8 20207877 PTHR31816:SF3 MICOS COMPLEX SUBUNIT MIC13 MICOS COMPLEX SUBUNIT MIC13 cellular component organization or biogenesis#GO:0071840;mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;membrane organization#GO:0061024 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane contact site#GO:0044232;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800 HELRO|EnsemblGenome=HelroG175212|UniProtKB=T1F907 T1F907 20205306 PTHR22146:SF17 CAT EYE SYNDROME CRITICAL REGION PROTEIN 6 PROTEIN FAM166B HELRO|EnsemblGenome=HelroG176995|UniProtKB=T1FB40 T1FB40 20206039 PTHR12394:SF12 ZYGIN LD08195P cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;axon#GO:0030424;neuron projection#GO:0043005 HELRO|EnsemblGenome=HelroG165358|UniProtKB=T1EWM8 T1EWM8 20200978 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92864|UniProtKB=T1G8M4 T1G8M4 20217421 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG185906|UniProtKB=T1FNF3 T1FNF3 20210350 PTHR12329:SF52 BCL2-ASSOCIATED ATHANOGENE BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 regulation of protein stability#GO:0031647;protein stabilization#GO:0050821;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;membrane#GO:0016020;nucleus#GO:0005634 chaperone#PC00072 Apoptosis signaling pathway#P00006>Bag#P00278 HELRO|EnsemblGenome=HelroG69263|UniProtKB=T1FZS1 T1FZS1 20214319 PTHR24418:SF463 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG179567|UniProtKB=T1FEV8 T1FEV8 20207357 PTHR23176:SF0 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE ACTIVATING PROTEIN AT 18B, ISOFORM C enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG130916|UniProtKB=T1EHU7 T1EHU7 20196147 PTHR12172:SF5 CELL CYCLE CHECKPOINT PROTEIN RAD17 CELL CYCLE CHECKPOINT PROTEIN RAD17 chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;mitotic G2/M transition checkpoint#GO:0044818;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;DNA replication checkpoint signaling#GO:0000076;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;mitotic DNA replication checkpoint signaling#GO:0033314;cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;site of DNA damage#GO:0090734;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;site of double-strand break#GO:0035861;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG174537|UniProtKB=T1F884 T1F884 20205033 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG74084|UniProtKB=T1G1M2 T1G1M2 20214970 PTHR11630:SF48 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA HELICASE MCM9 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG193546|UniProtKB=T1FV40 T1FV40 20212686 PTHR46402:SF2 SET AND MYND DOMAIN-CONTAINING PROTEIN 5 PROTEIN-LYSINE N-TRIMETHYLTRANSFERASE SMYD5 catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 negative regulation of cellular process#GO:0048523;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892 HELRO|EnsemblGenome=HelroG185228|UniProtKB=T1FMJ3 T1FMJ3 20210042 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG185714|UniProtKB=T1FN67 T1FN67 20210265 PTHR10730:SF45 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;collagen fibril organization#GO:0030199;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;Golgi apparatus#GO:0005794 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68344|UniProtKB=T1FZD4 T1FZD4 20214182 PTHR10738:SF0 PROTEIN ARGININE N-METHYLTRANSFERASE 5 PROTEIN ARGININE N-METHYLTRANSFERASE 5 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170648|UniProtKB=T1F3A1 T1F3A1 20203300 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407 HELRO|EnsemblGenome=HelroG69587|UniProtKB=T1FZW8 T1FZW8 20214366 PTHR23407:SF1 ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 metabolic process#GO:0008152;tetrahydrofolate biosynthetic process#GO:0046654;tetrahydrofolate metabolic process#GO:0046653;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ligase#PC00142 HELRO|EnsemblGenome=HelroG190363|UniProtKB=T1FRX5 T1FRX5 20211572 PTHR48051:SF21 FAMILY NOT NAMED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG181966|UniProtKB=T1FHJ2 T1FHJ2 20208291 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65269|UniProtKB=T1FY52 T1FY52 20213750 PTHR12086:SF9 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cytokinesis#GO:0000910;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;cytoskeleton-dependent cytokinesis#GO:0061640;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell division#GO:0051301;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;cell motility#GO:0048870;mitotic cytokinesis#GO:0000281;mitotic spindle organization#GO:0007052;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010 organelle#GO:0043226;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;axoneme#GO:0005930;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;spindle#GO:0005819;cytoskeleton#GO:0005856 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG68024|UniProtKB=T1FZ93 T1FZ93 20214141 PTHR46983:SF3 CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1 CHORD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177433|UniProtKB=T1FBP4 T1FBP4 20206243 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166849|UniProtKB=T1EYM5 T1EYM5 20201675 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG111546|UniProtKB=T1EFC3 T1EFC3 20195275 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME-RELATED extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG190749|UniProtKB=T1FS94 T1FS94 20211691 PTHR46100:SF4 IMP2'P USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74848|UniProtKB=T1G1W4 T1G1W4 20215062 PTHR11695:SF649 ALCOHOL DEHYDROGENASE RELATED NAD(P)H OXIDOREDUCTASE RTN4IP1, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158445|UniProtKB=T1EMS8 T1EMS8 20197878 PTHR43785:SF12 GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE TYPE-1 GLUTAMINE SYNTHETASE 2 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG183408|UniProtKB=T1FJL1 T1FJL1 20209010 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG174066|UniProtKB=T1F7J8 T1F7J8 20204797 PTHR11461:SF393 SERINE PROTEASE INHIBITOR, SERPIN SERPIN-ZX cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG170896|UniProtKB=T1F3K5 T1F3K5 20203404 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG193873|UniProtKB=T1FVF7 T1FVF7 20212803 PTHR42757:SF48 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG62725|UniProtKB=T1FX41 T1FX41 20213389 PTHR43429:SF2 PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING TRNA LIGASE COMPLEX-ASSOCIATED NAD(P)H DEHYDROGENASE PYROXD1 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG172004|UniProtKB=T1F4X7 T1F4X7 20203876 PTHR24260:SF149 AT07769P-RELATED AT07769P-RELATED HELRO|EnsemblGenome=HelroG90779|UniProtKB=T1G7W0 T1G7W0 20217157 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG175939|UniProtKB=T1F9X9 T1F9X9 20205628 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163839|UniProtKB=T1EUJ1 T1EUJ1 20200241 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179784|UniProtKB=T1FF55 T1FF55 20207454 PTHR25462:SF314 BONUS, ISOFORM C-RELATED TAM-1 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG194397|UniProtKB=T1FW06 T1FW06 20213002 PTHR11686:SF54 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 7 peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056;sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG171404|UniProtKB=T1F484 T1F484 20203633 PTHR46458:SF1 BLR2807 PROTEIN NEUROGLOBIN small molecule binding#GO:0036094;binding#GO:0005488;molecular carrier activity#GO:0140104 response to hypoxia#GO:0001666;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;response to stimulus#GO:0050896;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;response to stress#GO:0006950;response to abiotic stimulus#GO:0009628 transporter#PC00227 HELRO|EnsemblGenome=HelroG177420|UniProtKB=T1FBN6 T1FBN6 20206235 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4 INTERACTING CHROMATIN REMODELING COMPLEX ASSOCIATED PROTEIN, ISOFORM B regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG72614|UniProtKB=T1G125 T1G125 20214773 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG173409|UniProtKB=T1F6S5 T1F6S5 20204524 PTHR48209:SF4 AGL056WP C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174237|UniProtKB=T1F7U8 T1F7U8 20204897 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173811|UniProtKB=T1F794 T1F794 20204693 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188893|UniProtKB=T1FQG3 T1FQG3 20211060 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG190956|UniProtKB=T1FSG5 T1FSG5 20211762 PTHR12271:SF66 POLY A POLYMERASE CID PAP -RELATED GH05885P transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098 negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG63612|UniProtKB=T1FXI2 T1FXI2 20213530 PTHR24072:SF418 RHO FAMILY GTPASE MITOCHONDRIAL RHO GTPASE GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;organelle transport along microtubule#GO:0072384;mitochondrion organization#GO:0007005;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;signaling#GO:0023052;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;mitochondrion localization#GO:0051646;actin filament organization#GO:0007015;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;biological regulation#GO:0065007;cytoskeleton-dependent intracellular transport#GO:0030705;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;localization#GO:0051179;actin filament-based process#GO:0030029;organelle localization#GO:0051640;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;organelle outer membrane#GO:0031968;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG163765|UniProtKB=T1EUF9 T1EUF9 20200209 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194563|UniProtKB=T1FW73 T1FW73 20213069 PTHR24006:SF733 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12_46 HOMOLOG cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG180170|UniProtKB=T1FFJ5 T1FFJ5 20207594 PTHR12323:SF0 SR-RELATED CTD ASSOCIATED FACTOR 6 CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG87870|UniProtKB=T1G6W2 T1G6W2 20216809 PTHR13531:SF6 GEO07735P1-RELATED-RELATED TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 ciliary transition zone#GO:0035869;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG92244|UniProtKB=T1G8D4 T1G8D4 20217331 PTHR11711:SF451 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166 protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 G-protein#PC00020 HELRO|EnsemblGenome=HelroG162773|UniProtKB=T1ET44 T1ET44 20199744 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177290|UniProtKB=T1FBG6 T1FBG6 20206165 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG62653|UniProtKB=T1FX31 T1FX31 20213379 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG105715|UniProtKB=T1EDX1 T1EDX1 20194773 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HELRO|EnsemblGenome=HelroG72973|UniProtKB=T1G181 T1G181 20214829 PTHR24409:SF413 ZINC FINGER PROTEIN 142 DATILOGRAFO, ISOFORM A-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG185850|UniProtKB=T1FND1 T1FND1 20210328 PTHR11599:SF62 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-3 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG73017|UniProtKB=T1G187 T1G187 20214835 PTHR48078:SF19 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED L-SERINE DEAMINASE lyase activity#GO:0016829;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 dehydratase#PC00091;lyase#PC00144 Isoleucine biosynthesis#P02748>Threonine dehydratase#P02995 HELRO|EnsemblGenome=HelroG76268|UniProtKB=T1G2H5 T1G2H5 20215273 PTHR13321:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription initiation#GO:2000142;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG91019|UniProtKB=T1G7Y7 T1G7Y7 20217184 PTHR19229:SF275 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 establishment of localization#GO:0051234;localization#GO:0051179;lipid transport#GO:0006869;lipid localization#GO:0010876;macromolecule localization#GO:0033036;transport#GO:0006810 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG90349|UniProtKB=T1G7P5 T1G7P5 20217092 PTHR13049:SF2 DUF814-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 25 HELRO|EnsemblGenome=HelroG187585|UniProtKB=T1FPA8 T1FPA8 20210655 PTHR13121:SF0 GPI TRANSAMIDASE COMPONENT PIG-U GPI-ANCHOR TRANSAMIDASE COMPONENT PIGU metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;GPI anchored protein biosynthesis#GO:0180046;biosynthetic process#GO:0009058 endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endopeptidase complex#GO:1905369;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;caspase complex#GO:0008303;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG174523|UniProtKB=T1F880 T1F880 20205029 PTHR28348:SF1 UPF0193 PROTEIN EVG1 UPF0193 PROTEIN EVG1 HELRO|EnsemblGenome=HelroG193036|UniProtKB=T1FUJ8 T1FUJ8 20212494 PTHR45734:SF10 TENSIN BLISTERY, ISOFORM A cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG172856|UniProtKB=T1F608 T1F608 20204257 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179460|UniProtKB=T1FER1 T1FER1 20207310 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65753|UniProtKB=T1FYC4 T1FYC4 20213822 PTHR11849:SF289 ETS ETS-LIKE PROTEIN POINTED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG78741|UniProtKB=T1G3F2 T1G3F2 20215600 PTHR10159:SF541 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG183345|UniProtKB=T1FJH4 T1FJH4 20208973 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 steroid hydroxylase activity#GO:0008395;binding#GO:0005488;tetrapyrrole binding#GO:0046906;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;steroid metabolic process#GO:0008202 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164048|UniProtKB=T1EUT8 T1EUT8 20200338 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG194669|UniProtKB=T1FWA6 T1FWA6 20213102 PTHR16116:SF5 ZINC FINGER PROTEIN 839 ZINC FINGER PROTEIN 839 HELRO|EnsemblGenome=HelroG185262|UniProtKB=T1FMK7 T1FMK7 20210056 PTHR45761:SF1 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091;phosphatidylcholine binding#GO:0031210;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;lipid binding#GO:0008289;cation binding#GO:0043169 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG161638|UniProtKB=T1ERQ8 T1ERQ8 20199258 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;nuclear receptor activity#GO:0004879 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG81862|UniProtKB=T1G4J7 T1G4J7 20215995 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG191423|UniProtKB=T1FSZ0 T1FSZ0 20211937 PTHR13377:SF3 PLACENTAL PROTEIN 6 TRANSMEMBRANE PROTEIN 115 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193 Golgi cisterna#GO:0031985;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG177513|UniProtKB=T1FBT8 T1FBT8 20206287 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG168509|UniProtKB=T1F0N3 T1F0N3 20202383 PTHR45665:SF63 AQUAPORIN-8 AQUAPORIN OR AQUAGLYCEROPORIN RELATED-RELATED channel activity#GO:0015267;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;passive transmembrane transporter activity#GO:0022803 water transport#GO:0006833;localization#GO:0051179;establishment of localization#GO:0051234;fluid transport#GO:0042044;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG173161|UniProtKB=T1F6H3 T1F6H3 20204422 PTHR47027:SF32 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76765|UniProtKB=T1G2P1 T1G2P1 20215339 PTHR12989:SF10 ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10 DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220 HELRO|EnsemblGenome=HelroG179754|UniProtKB=T1FF44 T1FF44 20207443 PTHR18842:SF2 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1 HELRO|EnsemblGenome=HelroG75153|UniProtKB=T1G215 T1G215 20215113 PTHR12406:SF48 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4 hydrolase activity, acting on ester bonds#GO:0016788;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;triacylglycerol lipase activity#GO:0004806;acyltransferase activity#GO:0016746;hydrolase activity#GO:0016787 lipid catabolic process#GO:0016042;cellular process#GO:0009987;neutral lipid catabolic process#GO:0046461;chemical homeostasis#GO:0048878;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;homeostatic process#GO:0042592;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;triglyceride catabolic process#GO:0019433;glycerolipid catabolic process#GO:0046503 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG185539|UniProtKB=T1FMY2 T1FMY2 20210181 PTHR12370:SF3 N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE AMINOPEPTIDASE PLBD2-RELATED extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG158881|UniProtKB=T1END1 T1END1 20198081 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92624|UniProtKB=T1G8J0 T1G8J0 20217387 PTHR12270:SF25 GLYCOSYLTRANSFERASE-RELATED GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;xylosyltransferase activity#GO:0042285;glucuronosyltransferase activity#GO:0015020;pentosyltransferase activity#GO:0016763 glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG192222|UniProtKB=T1FTQ5 T1FTQ5 20212202 PTHR21027:SF1 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG82569|UniProtKB=T1G4U0 T1G4U0 20216088 PTHR43718:SF2 LON PROTEASE LON PROTEASE HOMOLOG, MITOCHONDRIAL DNA binding#GO:0003677;hydrolase activity#GO:0016787;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG113800|UniProtKB=T1EFW8 T1EFW8 20195470 PTHR11630:SF42 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM5 catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG169917|UniProtKB=T1F2G0 T1F2G0 20203010 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG77983|UniProtKB=T1G360 T1G360 20215508 PTHR15599:SF1 RTDR1 RADIAL SPOKE HEAD 14 HOMOLOG HELRO|EnsemblGenome=HelroG176287|UniProtKB=T1FAD3 T1FAD3 20205782 PTHR14063:SF1 PROTEIN LIN-7 HOMOLOG PDZ DOMAIN-CONTAINING PROTEIN 11 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;cellular component biogenesis#GO:0044085;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;cellular localization#GO:0051641;regulation of synapse organization#GO:0050807;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;export from cell#GO:0140352;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;establishment of localization#GO:0051234;transport#GO:0006810;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of synapse assembly#GO:0051963;vesicle localization#GO:0051648;regulation of synapse structure or activity#GO:0050803;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;regulation of cell junction assembly#GO:1901888;organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of growth#GO:0040008;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643 anchoring junction#GO:0070161;cell junction#GO:0030054;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG185893|UniProtKB=T1FNE6 T1FNE6 20210343 PTHR12109:SF3 RING FINGER PROTEIN 141-RELATED RING FINGER PROTEIN 141 aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG90376|UniProtKB=T1G7Q2 T1G7Q2 20217099 PTHR12636:SF5 NEP1/MRA1 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1 catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;rRNA binding#GO:0019843;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on a rRNA#GO:0140102;RNA binding#GO:0003723 methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;rRNA base methylation#GO:0070475;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;small-subunit processome#GO:0032040;organelle lumen#GO:0043233 methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG179132|UniProtKB=T1FE79 T1FE79 20207128 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182534|UniProtKB=T1FIB7 T1FIB7 20208566 PTHR19282:SF549 TETRASPANIN TETRASPANIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194469|UniProtKB=T1FW33 T1FW33 20213029 PTHR11814:SF272 SULFATE TRANSPORTER SOLUTE CARRIER FAMILY 26 MEMBER 10P-RELATED dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;carboxylic acid transmembrane transporter activity#GO:0046943 monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transport#GO:0006810;chloride transport#GO:0006821 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG169643|UniProtKB=T1F273 T1F273 20202923 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;cellular process#GO:0009987;muscle system process#GO:0003012;cellular component organization#GO:0016043;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;system process#GO:0003008;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;muscle contraction#GO:0006936 actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG135186|UniProtKB=T1EI72 T1EI72 20196272 PTHR12775:SF0 PROTEIN C20ORF43 HOMOLOG REPLICATION TERMINATION FACTOR 2 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG183274|UniProtKB=T1FJE5 T1FJE5 20208944 PTHR10130:SF0 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR signal sequence receptor activity#GO:0005048;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;peroxisome organization#GO:0007031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;peroxisomal transport#GO:0043574;protein transport#GO:0015031;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;protein import into peroxisome matrix#GO:0016558 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG106331|UniProtKB=T1EE21 T1EE21 20194823 PTHR24390:SF271 ZINC FINGER PROTEIN FI23536P1-RELATED double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG93050|UniProtKB=T1G8S1 T1G8S1 20217468 PTHR24347:SF457 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;energy reserve metabolic process#GO:0006112;cell communication#GO:0007154;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;polysaccharide metabolic process#GO:0005976;response to stimulus#GO:0050896;signaling#GO:0023052;carbohydrate metabolic process#GO:0005975 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG110470|UniProtKB=T1EF24 T1EF24 20195176 PTHR11908:SF168 XANTHINE DEHYDROGENASE XANTHINE DEHYDROGENASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Purine metabolism#P02769>Xanthine Oxidase#P03116;Adenine and hypoxanthine salvage pathway#P02723>Xanthine dehydrogenase#P02809 HELRO|EnsemblGenome=HelroG184211|UniProtKB=T1FKR9 T1FKR9 20209418 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG86484|UniProtKB=T1G6D0 T1G6D0 20216627 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG172151|UniProtKB=T1F526 T1F526 20203925 PTHR14017:SF32 LYSINE-SPECIFIC DEMETHYLASE LD02225P oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;chromatin DNA binding#GO:0031490;catalytic activity#GO:0003824;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;sequence-specific double-stranded DNA binding#GO:1990837;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;dioxygenase activity#GO:0051213;cis-regulatory region sequence-specific DNA binding#GO:0000987;histone demethylase activity#GO:0032452;sequence-specific DNA binding#GO:0043565;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;binding#GO:0005488;histone modifying activity#GO:0140993;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG158244|UniProtKB=T1EML1 T1EML1 20197811 PTHR22602:SF0 IRON-SULFUR CLUSTER ASSEMBLY FACTOR CAF17/IBA57, MITOCHONDRIAL IRON-SULFUR CLUSTER ASSEMBLY FACTOR IBA57, MITOCHONDRIAL cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG191041|UniProtKB=T1FSJ2 T1FSJ2 20211789 PTHR12738:SF0 NEUROENDOCRINE PROTEIN 7B2 NEUROENDOCRINE PROTEIN 7B2 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;regulation of hormone secretion#GO:0046883;regulation of secretion#GO:0051046;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817 chaperone#PC00072 HELRO|EnsemblGenome=HelroG84296|UniProtKB=T1G5H2 T1G5H2 20216319 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG161640|UniProtKB=T1ERR0 T1ERR0 20199260 PTHR47013:SF1 SPLICING FACTOR, ARGININE/SERINE-RICH 19 SPLICING FACTOR, ARGININE_SERINE-RICH 19 binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG189807|UniProtKB=T1FRD7 T1FRD7 20211384 PTHR10292:SF46 CLATHRIN HEAVY CHAIN RELATED CLATHRIN HEAVY CHAIN protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 coated membrane#GO:0048475;membrane coat#GO:0030117;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;cell cortex#GO:0005938;vesicle#GO:0031982;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle#GO:0030136;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 vesicle coat protein#PC00235;membrane traffic protein#PC00150 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722 HELRO|EnsemblGenome=HelroG175156|UniProtKB=T1F8X6 T1F8X6 20205275 PTHR24322:SF755 PKSB RETINOL DEHYDROGENASE 10 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 intracellular organelle#GO:0043229;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG186086|UniProtKB=T1FNN0 T1FNN0 20210427 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG97768|UniProtKB=T1G9I9 T1G9I9 20217736 PTHR12360:SF1 NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1 NF-X1-TYPE ZINC FINGER PROTEIN NFXL1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186383|UniProtKB=T1FNY9 T1FNY9 20210536 PTHR16469:SF27 UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BB-RELATED HELRO|EnsemblGenome=HelroG179689|UniProtKB=T1FF13 T1FF13 20207412 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG185005|UniProtKB=T1FM96 T1FM96 20209945 PTHR43178:SF18 LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED CHAIN ALPHA_KETOACID DEHYDROGENASE COMPLEX LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;oxidoreductase complex#GO:1990204 transferase#PC00220;acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG171761|UniProtKB=T1F4M1 T1F4M1 20203770 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 cellular anatomical structure#GO:0110165;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG157214|UniProtKB=T1EM83 T1EM83 20197683 PTHR10759:SF0 60S RIBOSOMAL PROTEIN L34 LARGE RIBOSOMAL SUBUNIT PROTEIN EL34 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG107348|UniProtKB=T1EE98 T1EE98 20194900 PTHR22884:SF498 SET DOMAIN PROTEINS NUCLEAR RECEPTOR BINDING SET DOMAIN PROTEIN catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;histone H3K36 methyltransferase activity#GO:0046975;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG185663|UniProtKB=T1FN40 T1FN40 20210238 PTHR10410:SF5 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED UBIQUITIN C-TERMINAL HYDROLASE PSMD14 metallopeptidase activity#GO:0008237;deubiquitinase activity#GO:0101005;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;proteasome complex#GO:0000502;nucleus#GO:0005634 translation initiation factor#PC00224;translation factor#PC00223 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG159141|UniProtKB=T1ENN3 T1ENN3 20198183 PTHR33337:SF40 GFA DOMAIN-CONTAINING PROTEIN CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG163505|UniProtKB=T1EU52 T1EU52 20200102 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG193007|UniProtKB=T1FUI3 T1FUI3 20212479 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG195048|UniProtKB=T1FWP9 T1FWP9 20213244 PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG186293|UniProtKB=T1FNX8 T1FNX8 20210525 PTHR12935:SF0 GAMMA-GLUTAMYLCYCLOTRANSFERASE GAMMA-GLUTAMYLCYCLOTRANSFERASE catalytic activity#GO:0003824;lyase activity#GO:0016829 HELRO|EnsemblGenome=HelroG186273|UniProtKB=T1FNW3 T1FNW3 20210510 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE FI04477P-RELATED phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;cell communication#GO:0007154;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;lipid modification#GO:0030258 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG165452|UniProtKB=T1EWT8 T1EWT8 20201038 PTHR33244:SF8 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83340|UniProtKB=T1G545 T1G545 20216193 PTHR34524:SF6 CALCYPHOSIN CALCYPHOSINE LIKE calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG193255|UniProtKB=T1FUS9 T1FUS9 20212575 PTHR23302:SF24 TRANSMEMBRANE CHANNEL-RELATED TMC DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;gated channel activity#GO:0022836;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HELRO|EnsemblGenome=HelroG177915|UniProtKB=T1FCG6 T1FCG6 20206515 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG154963|UniProtKB=T1ELG8 T1ELG8 20197418 PTHR23430:SF50 HISTONE H2A HISTONE H2A structural molecule activity#GO:0005198 heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG175124|UniProtKB=T1F8W0 T1F8W0 20205259 PTHR13793:SF169 PHD FINGER PROTEINS BROMODOMAIN-CONTAINING PROTEIN HOMOLOG chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG161897|UniProtKB=T1ES05 T1ES05 20199355 PTHR47372:SF11 DAUER UP-REGULATED-RELATED RE19971P HELRO|EnsemblGenome=HelroG180225|UniProtKB=T1FFL3 T1FFL3 20207612 PTHR23511:SF34 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2B ISOFORM X1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG177311|UniProtKB=T1FBH5 T1FBH5 20206174 PTHR24390:SF148 ZINC FINGER PROTEIN CTCF sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG168741|UniProtKB=T1F0W8 T1F0W8 20202468 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG162664|UniProtKB=T1ESZ4 T1ESZ4 20199694 PTHR20872:SF1 FAMILY NOT NAMED F-BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170997|UniProtKB=T1F3P0 T1F3P0 20203439 PTHR11785:SF528 AMINO ACID TRANSPORTER LD25378P L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;amino acid transport#GO:0006865;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG162802|UniProtKB=T1ET65 T1ET65 20199765 PTHR46670:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76581|UniProtKB=T1G2L6 T1G2L6 20215314 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176734|UniProtKB=T1FAU7 T1FAU7 20205946 PTHR23349:SF68 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FI14601P transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG86082|UniProtKB=T1G671 T1G671 20216568 PTHR10126:SF37 TATA-BOX BINDING PROTEIN TATA BOX-BINDING PROTEIN-LIKE 2 DNA-templated transcription#GO:0006351;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;gene expression#GO:0010467;DNA-templated transcription initiation#GO:0006352;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>TBP#P00657;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399 HELRO|EnsemblGenome=HelroG181443|UniProtKB=T1FH04 T1FH04 20208103 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;channel activity#GO:0015267;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;transporter activity#GO:0005215;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488 establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;regulation of cytosolic calcium ion concentration#GO:0051480 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG83167|UniProtKB=T1G514 T1G514 20216162 PTHR45849:SF7 FACT COMPLEX SUBUNIT SSRP1 FACT COMPLEX SUBUNIT SSRP1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of chromatin organization#GO:1902275 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG176662|UniProtKB=T1FAS1 T1FAS1 20205920 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167913|UniProtKB=T1EZY2 T1EZY2 20202132 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62694|UniProtKB=T1FX37 T1FX37 20213385 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG171830|UniProtKB=T1F4R3 T1F4R3 20203812 PTHR12522:SF4 ZINC-FINGER PROTEIN NOLZ1-RELATED ZINC FINGER PROTEIN ELBOW regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG90499|UniProtKB=T1G7S3 T1G7S3 20217120 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191248|UniProtKB=T1FSS6 T1FSS6 20211873 PTHR12688:SF5 DYNEIN LIGHT INTERMEDIATE CHAIN DYNEIN LIGHT INTERMEDIATE CHAIN protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG66074|UniProtKB=T1FYG6 T1FYG6 20213864 PTHR20951:SF2 C13ORF1 PROTEIN-RELATED SPRY DOMAIN-CONTAINING PROTEIN 7 HELRO|EnsemblGenome=HelroG184530|UniProtKB=T1FLE7 T1FLE7 20209646 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG163325|UniProtKB=T1ETW9 T1ETW9 20200019 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173118|UniProtKB=T1F6E2 T1F6E2 20204391 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG164071|UniProtKB=T1EUV6 T1EUV6 20200356 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81620|UniProtKB=T1G4G6 T1G4G6 20215964 PTHR45629:SF13 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-LIKE ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;DNA translocase activity#GO:0015616 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG160589|UniProtKB=T1EQG5 T1EQG5 20198815 PTHR15180:SF1 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;rRNA transcription#GO:0009303;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription initiation#GO:0006352 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;transcription factor TFIIIC complex#GO:0000127 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG98239|UniProtKB=T1G9L1 T1G9L1 20217757 PTHR11601:SF62 CYSTEINE DESULFURYLASE FAMILY MEMBER SELENOCYSTEINE LYASE lyase#PC00144;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG71159|UniProtKB=T1G0H2 T1G0H2 20214570 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG175375|UniProtKB=T1F975 T1F975 20205374 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176987|UniProtKB=T1FB35 T1FB35 20206034 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG189204|UniProtKB=T1FQS5 T1FQS5 20211172 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG91349|UniProtKB=T1G828 T1G828 20217225 PTHR48021:SF1 FAMILY NOT NAMED MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG185317|UniProtKB=T1FMN5 T1FMN5 20210084 PTHR13056:SF0 VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;late endosome#GO:0005770;guanyl-nucleotide exchange factor complex#GO:0032045;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG183997|UniProtKB=T1FKE4 T1FKE4 20209293 PTHR12755:SF3 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9 nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 mRNA polyadenylation factor#PC00146;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108064|UniProtKB=T1EEE9 T1EEE9 20194951 PTHR45976:SF1 ARMADILLO SEGMENT POLARITY PROTEIN ARMADILLO SEGMENT POLARITY PROTEIN protein phosphatase binding#GO:0019903;transcription coactivator activity#GO:0003713;cell adhesion molecule binding#GO:0050839;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;phosphatase binding#GO:0019902;binding#GO:0005488 response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cell adhesion#GO:0007155;positive regulation of macromolecule metabolic process#GO:0010604;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944;cell surface receptor signaling pathway#GO:0007166;regulation of macromolecule metabolic process#GO:0060255;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell periphery#GO:0071944;nucleus#GO:0005634;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;adherens junction#GO:0005912;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897 p53 pathway feedback loops 2#P04398>beta-catenin#P04670;Cadherin signaling pathway#P00012>betacatenin#P00463;Wnt signaling pathway#P00057>Beta-Catenin#P01432;Angiogenesis#P00005>beta catenin#P00187;Alzheimer disease-presenilin pathway#P00004>beta-catenin#P00156 HELRO|EnsemblGenome=HelroG189138|UniProtKB=T1FQQ0 T1FQQ0 20211147 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR MELATONIN RECEPTOR PDCR-1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG172362|UniProtKB=T1F583 T1F583 20203982 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG170818|UniProtKB=T1F3G8 T1F3G8 20203367 PTHR38636:SF1 PROTEIN CBG20488 CHLORIDE CHANNEL PROTEIN CLC-D HELRO|EnsemblGenome=HelroG103204|UniProtKB=T1EDF0 T1EDF0 20194602 PTHR20886:SF11 VANG-LIKE PROTEIN VANG-LIKE PROTEIN regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;non-canonical Wnt signaling pathway#GO:0035567;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;cell communication#GO:0007154;tissue morphogenesis#GO:0048729;animal gross anatomical part developmental process#GO:0160108;tissue development#GO:0009888;epithelium development#GO:0060429;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;morphogenesis of an epithelium#GO:0002009;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG193281|UniProtKB=T1FUT9 T1FUT9 20212585 PTHR13043:SF1 EXOCYST COMPLEX COMPONENT SEC5 EXOCYST COMPLEX COMPONENT 2 cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;transport#GO:0006810;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;secretion by cell#GO:0032940;exocytosis#GO:0006887 intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;exocyst#GO:0000145;cell periphery#GO:0071944;cell cortex#GO:0005938 Ras Pathway#P04393>Sec5#P04545 HELRO|EnsemblGenome=HelroG161235|UniProtKB=T1ER87 T1ER87 20199087 PTHR12485:SF1 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7 mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980 organelle membrane#GO:0031090;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;mitochondrial inner membrane#GO:0005743;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106206|UniProtKB=T1EE08 T1EE08 20194810 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;ATP binding#GO:0005524;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;catalytic activity#GO:0003824;purine ribonucleoside triphosphate binding#GO:0035639;nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491 biosynthetic process#GO:0009058;metabolic process#GO:0008152;cellular process#GO:0009987 catalytic complex#GO:1902494;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo purine biosynthesis#P02738>GDP reductase#P02909;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921 HELRO|EnsemblGenome=HelroG81783|UniProtKB=T1G4I7 T1G4I7 20215985 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG100933|UniProtKB=T1ED21 T1ED21 20194473 PTHR11629:SF114 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A binding#GO:0005488;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;enzyme binding#GO:0019899;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;proton transmembrane transport#GO:1902600;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG166735|UniProtKB=T1EYG2 T1EYG2 20201612 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158637|UniProtKB=T1EN22 T1EN22 20197972 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168052|UniProtKB=T1F040 T1F040 20202190 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158526|UniProtKB=T1EMW9 T1EMW9 20197919 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166646|UniProtKB=T1EYB4 T1EYB4 20201564 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG116769|UniProtKB=T1EGH5 T1EGH5 20195677 PTHR11556:SF1 FRUCTOSE-1,6-BISPHOSPHATASE-RELATED FRUCTOSE-1,6-BISPHOSPHATASE ISOZYME 2 sugar-phosphatase activity#GO:0050308;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;carbohydrate biosynthetic process#GO:0016051;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;gluconeogenesis#GO:0006094;hexose biosynthetic process#GO:0019319;cellular process#GO:0009987;glucose metabolic process#GO:0006006;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;small molecule biosynthetic process#GO:0044283 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121;carbohydrate phosphatase#PC00066 HELRO|EnsemblGenome=HelroG178473|UniProtKB=T1FD80 T1FD80 20206779 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG168850|UniProtKB=T1F115 T1F115 20202515 PTHR47641:SF13 PERIAXIN-LIKE SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG73491|UniProtKB=T1G1E4 T1G1E4 20214892 PTHR22761:SF12 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 5 vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle budding from membrane#GO:0006900;nuclear envelope organization#GO:0006998;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;nuclear membrane organization#GO:0071763;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;localization#GO:0051179;cellular localization#GO:0051641;membrane assembly#GO:0071709;cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nucleus#GO:0005634;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181401|UniProtKB=T1FGY9 T1FGY9 20208088 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD CASPASE DRONC positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;positive regulation of cell communication#GO:0010647;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG67113|UniProtKB=T1FYW6 T1FYW6 20214014 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG69189|UniProtKB=T1FZQ7 T1FZQ7 20214305 PTHR28583:SF1 ACID AMIDASE ACID CERAMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG163462|UniProtKB=T1EU30 T1EU30 20200080 PTHR24034:SF209 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG69911|UniProtKB=T1FZZ5 T1FZZ5 20214393 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69796|UniProtKB=T1FZY6 T1FZY6 20214384 PTHR23353:SF38 RAB-GAP/TBC-RELATED TRANSMEMBRANE PROTEIN GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG175856|UniProtKB=T1F9S5 T1F9S5 20205574 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG76296|UniProtKB=T1G2I0 T1G2I0 20215278 PTHR10048:SF22 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4-KINASE BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;phosphatidylinositol phosphate biosynthetic process#GO:0046854 membrane#GO:0016020;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG185559|UniProtKB=T1FMZ4 T1FMZ4 20210193 PTHR24067:SF157 UBIQUITIN-CONJUGATING ENZYME E2 FI11905P ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631 catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG177528|UniProtKB=T1FBU5 T1FBU5 20206294 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72599|UniProtKB=T1G124 T1G124 20214772 PTHR10366:SF404 NAD DEPENDENT EPIMERASE/DEHYDRATASE NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG191720|UniProtKB=T1FT82 T1FT82 20212029 PTHR21597:SF0 THO2 PROTEIN THO COMPLEX SUBUNIT 2 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;transcription export complex#GO:0000346;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG108094|UniProtKB=T1EEF3 T1EEF3 20194955 PTHR11699:SF190 ALDEHYDE DEHYDROGENASE-RELATED 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;tetrahydrofolate metabolic process#GO:0046653;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG81234|UniProtKB=T1G4B9 T1G4B9 20215917 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG74964|UniProtKB=T1G1Y7 T1G1Y7 20215085 PTHR19384:SF10 NITRIC OXIDE SYNTHASE-RELATED NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1 small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;ribonucleotide binding#GO:0032553;catalytic activity#GO:0003824;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG75443|UniProtKB=T1G252 T1G252 20215150 PTHR11183:SF204 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN GLUCOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG75040|UniProtKB=T1G1Z7 T1G1Z7 20215095 PTHR23085:SF16 GH28348P GH28348P nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG181006|UniProtKB=T1FGI6 T1FGI6 20207935 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72124|UniProtKB=T1G0W0 T1G0W0 20214708 PTHR15382:SF8 CTG4A-RELATED CANOPY B HELRO|EnsemblGenome=HelroG188556|UniProtKB=T1FQ42 T1FQ42 20210939 PTHR46297:SF1 ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG107427|UniProtKB=T1EEA4 T1EEA4 20194906 PTHR10858:SF23 DEOXYRIBONUCLEASE II DEOXYRIBONUCLEASE II DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787 programmed cell death#GO:0012501;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell death#GO:0008219;apoptotic process#GO:0006915;execution phase of apoptosis#GO:0097194;catabolic process#GO:0009056;DNA catabolic process#GO:0006308;cellular component disassembly#GO:0022411;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound metabolic process#GO:0006139;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG87174|UniProtKB=T1G6M9 T1G6M9 20216726 PTHR13160:SF4 OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG172690|UniProtKB=T1F5S7 T1F5S7 20204176 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192675|UniProtKB=T1FU64 T1FU64 20212360 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG120014|UniProtKB=T1EGP2 T1EGP2 20195742 PTHR12305:SF100 PHOSPHATASE WITH HOMOLOGY TO TENSIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896 organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Hypoxia response via HIF activation#P00030>PTEN#P00824;p53 pathway#P00059>PTEN#G01579;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#G04675;p53 pathway#P00059>PTEN#P01480;PI3 kinase pathway#P00048>PTEN#P01189;p53 pathway feedback loops 2#P04398>PTEN#G04714;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#P00905;p53 pathway feedback loops 2#P04398>PTEN#P04658 HELRO|EnsemblGenome=HelroG103925|UniProtKB=T1EDI6 T1EDI6 20194638 PTHR47977:SF123 RAS-RELATED PROTEIN RAB EG:80H7.4 PROTEIN guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;establishment of localization#GO:0051234;regulation of localization#GO:0032879;exocytosis#GO:0006887;regulation of transport#GO:0051049;transport#GO:0006810;regulation of cellular process#GO:0050794;export from cell#GO:0140352;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;secretion#GO:0046903;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;positive regulation of secretion#GO:0051047 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;apical plasma membrane#GO:0016324;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;Golgi apparatus#GO:0005794;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;endomembrane system#GO:0012505 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG179049|UniProtKB=T1FE37 T1FE37 20207086 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110129|UniProtKB=T1EEZ6 T1EEZ6 20195148 PTHR11409:SF42 ADENOSINE DEAMINASE N6-METHYL-AMP DEAMINASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;adenosine deaminase activity#GO:0004000;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239 carbohydrate derivative biosynthetic process#GO:1901137;purine-containing compound catabolic process#GO:0072523;nucleobase metabolic process#GO:0009112;purine nucleoside catabolic process#GO:0006152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;purine nucleobase metabolic process#GO:0006144;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;adenosine metabolic process#GO:0046085;carbohydrate derivative metabolic process#GO:1901135;nucleoside catabolic process#GO:0009164;purine-containing compound biosynthetic process#GO:0072522;purine nucleoside metabolic process#GO:0042278;nucleoside metabolic process#GO:0009116;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;purine-containing compound metabolic process#GO:0072521 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 deaminase#PC00088 Adenine and hypoxanthine salvage pathway#P02723>Adenosine deaminase#P02811;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine deaminase#P02807 HELRO|EnsemblGenome=HelroG103167|UniProtKB=T1EDE7 T1EDE7 20194599 PTHR14898:SF0 ENHANCER OF POLYCOMB ENHANCER OF POLYCOMB-LIKE PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164928|UniProtKB=T1EVZ4 T1EVZ4 20200744 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158501|UniProtKB=T1EMV2 T1EMV2 20197902 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182050|UniProtKB=T1FHN4 T1FHN4 20208333 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193067|UniProtKB=T1FUL2 T1FUL2 20212508 PTHR19282:SF452 TETRASPANIN LD03691P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162406|UniProtKB=T1ESM1 T1ESM1 20199571 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193469|UniProtKB=T1FV11 T1FV11 20212657 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68781|UniProtKB=T1FZJ5 T1FZJ5 20214243 PTHR22883:SF43 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE APP catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein targeting#GO:0006605 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105484|UniProtKB=T1EDV5 T1EDV5 20194757 PTHR11472:SF1 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;damaged DNA binding#GO:0003684;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094 RNA metabolic process#GO:0016070;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;response to stimulus#GO:0050896;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG193777|UniProtKB=T1FVC4 T1FVC4 20212770 PTHR10529:SF270 AP COMPLEX SUBUNIT MU AP-4 COMPLEX SUBUNIT MU-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 lysosomal transport#GO:0007041;localization#GO:0051179;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;post-Golgi vesicle-mediated transport#GO:0006892;protein targeting#GO:0006605;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;AP-type membrane coat adaptor complex#GO:0030119;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG64438|UniProtKB=T1FXU9 T1FXU9 20213647 PTHR11136:SF5 FOLYLPOLYGLUTAMATE SYNTHASE-RELATED FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;biosynthetic process#GO:0009058;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ligase#PC00142 Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate synthase#P02958;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943 HELRO|EnsemblGenome=HelroG176847|UniProtKB=T1FAY9 T1FAY9 20205988 PTHR12709:SF5 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription by RNA polymerase I#GO:0006360;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase I complex#GO:0005736;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG184992|UniProtKB=T1FM87 T1FM87 20209936 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT AT04468P-RELATED ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 import across plasma membrane#GO:0098739;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;inorganic ion import across plasma membrane#GO:0099587;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 ATPase dependent transmembrane transport complex#GO:0098533;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG184875|UniProtKB=T1FM41 T1FM41 20209890 PTHR10953:SF162 UBIQUITIN-ACTIVATING ENZYME E1 SUMO-ACTIVATING ENZYME SUBUNIT 1 catalytic activity, acting on a protein#GO:0140096;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein sumoylation#GO:0016925;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG75318|UniProtKB=T1G236 T1G236 20215134 PTHR24033:SF224 EGF-LIKE DOMAIN-CONTAINING PROTEIN PROTEIN EYES SHUT HELRO|EnsemblGenome=HelroG106160|UniProtKB=T1EE06 T1EE06 20194808 PTHR14102:SF11 PAR-6-RELATED LD29223P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cell-cell junction maintenance#GO:0045217;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;establishment or maintenance of cell polarity#GO:0007163;cytoskeleton organization#GO:0007010;cell junction organization#GO:0034330;cell cycle process#GO:0022402;cellular process#GO:0009987;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737 tight junction#PC00214;cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG110320|UniProtKB=T1EF13 T1EF13 20195165 PTHR10925:SF5 N-ACETYLTRANSFERASE 10 RNA CYTIDINE ACETYLTRANSFERASE catalytic activity, acting on RNA#GO:0140098;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a tRNA#GO:0140101;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746 rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble base modification#GO:0002097;tRNA modification#GO:0006400;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 organelle lumen#GO:0043233;small-subunit processome#GO:0032040;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG165702|UniProtKB=T1EX69 T1EX69 20201169 PTHR23352:SF2 NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1 HELRO|EnsemblGenome=HelroG189751|UniProtKB=T1FRC1 T1FRC1 20211368 PTHR23150:SF33 SULFATASE MODIFYING FACTOR 1, 2 INACTIVE C-ALPHA-FORMYLGLYCINE-GENERATING ENZYME 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG106777|UniProtKB=T1EE48 T1EE48 20194850 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;signaling#GO:0023052;cellular response to stress#GO:0033554;regulation of translational initiation#GO:0006446;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG156666|UniProtKB=T1ELZ7 T1ELZ7 20197597 PTHR11267:SF195 T-BOX PROTEIN-RELATED OPTOMOTOR-BLIND-RELATED-GENE-1, ISOFORM A double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG106476|UniProtKB=T1EE28 T1EE28 20194830 PTHR10177:SF347 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554 kinase activator#PC00138 p53 pathway#P00059>Cyclin B#P04614;Cell cycle#P00013>Cyclin B#P00486 HELRO|EnsemblGenome=HelroG193268|UniProtKB=T1FUT4 T1FUT4 20212580 PTHR13817:SF166 TITIN MYOMESIN AND MYOSIN BINDING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG89106|UniProtKB=T1G787 T1G787 20216934 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG97485|UniProtKB=T1G9H2 T1G9H2 20217719 PTHR33562:SF18 ATILLA, ISOFORM B-RELATED-RELATED RE19849P-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG168367|UniProtKB=T1F0H5 T1F0H5 20202325 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG89102|UniProtKB=T1G785 T1G785 20216932 PTHR45973:SF12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED DYNEIN REGULATORY COMPLEX SUBUNIT 3 cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG179427|UniProtKB=T1FEP2 T1FEP2 20207291 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG107062|UniProtKB=T1EE70 T1EE70 20194872 PTHR23077:SF27 AAA-FAMILY ATPASE ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111 ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG90384|UniProtKB=T1G7Q4 T1G7Q4 20217101 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG157004|UniProtKB=T1EM48 T1EM48 20197648 PTHR10369:SF3 60S RIBOSOMAL PROTEIN L36A/L44 RIBOSOMAL PROTEIN L36A structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG114027|UniProtKB=T1EFY3 T1EFY3 20195485 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;plasma membrane#GO:0005886 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG186672|UniProtKB=T1FP22 T1FP22 20210569 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;cellular process#GO:0009987;transmembrane transport#GO:0055085;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG178932|UniProtKB=T1FDX1 T1FDX1 20207020 PTHR10671:SF116 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG185300|UniProtKB=T1FMM8 T1FMM8 20210077 PTHR12976:SF0 RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG63354|UniProtKB=T1FXE7 T1FXE7 20213495 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG160724|UniProtKB=T1EQN1 T1EQN1 20198881 PTHR14166:SF17 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO-GAP DOMAIN-CONTAINING PROTEIN enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;G-protein modulator#PC00022 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG183927|UniProtKB=T1FKB1 T1FKB1 20209260 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG184688|UniProtKB=T1FLS0 T1FLS0 20209769 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185090|UniProtKB=T1FMD8 T1FMD8 20209987 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191785|UniProtKB=T1FTB6 T1FTB6 20212063 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular region#GO:0005576;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG66825|UniProtKB=T1FYR6 T1FYR6 20213964 PTHR24235:SF29 NEUROPEPTIDE Y RECEPTOR GH23382P neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG82169|UniProtKB=T1G4N8 T1G4N8 20216036 PTHR31488:SF1 DPY-19-LIKE 1, LIKE (H. SAPIENS) DPY-19 LIKE C-MANNOSYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HELRO|EnsemblGenome=HelroG99952|UniProtKB=T1G9V8 T1G9V8 20217854 PTHR14052:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 2 ORIGIN RECOGNITION COMPLEX SUBUNIT 2 sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688 cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261 membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;nuclear origin of replication recognition complex#GO:0005664;nuclear protein-containing complex#GO:0140513;origin recognition complex#GO:0000808;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;chromosome#GO:0005694;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG69296|UniProtKB=T1FZT0 T1FZT0 20214328 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;muscle system process#GO:0003012;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;system process#GO:0003008;supramolecular fiber organization#GO:0097435;muscle contraction#GO:0006936;actin filament-based process#GO:0030029 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG75190|UniProtKB=T1G224 T1G224 20215122 PTHR11575:SF50 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;purine ribonucleotide catabolic process#GO:0009154;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;purine nucleotide catabolic process#GO:0006195;ribonucleotide metabolic process#GO:0009259;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG112090|UniProtKB=T1EFH0 T1EFH0 20195322 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG179666|UniProtKB=T1FF03 T1FF03 20207402 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG192619|UniProtKB=T1FU48 T1FU48 20212344 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193605|UniProtKB=T1FV62 T1FV62 20212708 PTHR14309:SF10 EXPRESSED PROTEIN PH DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG180072|UniProtKB=T1FFG0 T1FFG0 20207559 PTHR47385:SF14 CALPONIN TRANSGELIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG175027|UniProtKB=T1F8Q8 T1F8Q8 20205207 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184748|UniProtKB=T1FLX3 T1FLX3 20209822 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG68094|UniProtKB=T1FZA1 T1FZA1 20214149 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231 chloride transport#GO:0006821;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG194925|UniProtKB=T1FWK7 T1FWK7 20213202 PTHR12450:SF22 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN KINASE FAM20C-LIKE ISOFORM X1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG188977|UniProtKB=T1FQI9 T1FQI9 20211086 PTHR23349:SF72 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST HLH54F sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG191993|UniProtKB=T1FTH7 T1FTH7 20212124 PTHR23085:SF16 GH28348P GH28348P intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG195099|UniProtKB=T1FWR0 T1FWR0 20213255 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG174897|UniProtKB=T1F8L3 T1F8L3 20205162 PTHR23113:SF363 GUANINE NUCLEOTIDE EXCHANGE FACTOR PROTEIN SON OF SEVENLESS GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 Ras Pathway#P04393>SOS#P04552;Integrin signalling pathway#P00034>SOS#P00920;PDGF signaling pathway#P00047>SOS#P01159;EGF receptor signaling pathway#P00018>SOS#P00558;Angiogenesis#P00005>SOS-1#P00193;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;FGF signaling pathway#P00021>SOS#P00641 HELRO|EnsemblGenome=HelroG190767|UniProtKB=T1FSA1 T1FSA1 20211698 PTHR15504:SF0 NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45 regulation of cell motility#GO:2000145;regulation of biological quality#GO:0065008;regulation of microtubule-based process#GO:0032886;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG89451|UniProtKB=T1G7D0 T1G7D0 20216977 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG185826|UniProtKB=T1FNC2 T1FNC2 20210319 PTHR11240:SF22 RIBONUCLEASE T2 RIBONUCLEASE X25 endonuclease activity#GO:0004519;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 RNA catabolic process#GO:0006401;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG91638|UniProtKB=T1G869 T1G869 20217266 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65617|UniProtKB=T1FYA7 T1FYA7 20213805 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG188076|UniProtKB=T1FPL7 T1FPL7 20210764 PTHR21540:SF3 RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2 E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG102896|UniProtKB=T1EDC8 T1EDC8 20194580 PTHR12606:SF141 SENTRIN/SUMO-SPECIFIC PROTEASE GH15225P-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;post-translational protein modification#GO:0043687 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190 HELRO|EnsemblGenome=HelroG71494|UniProtKB=T1G0M3 T1G0M3 20214621 PTHR46810:SF1 INACTIVE POLYGLYCYLASE TTLL10 INACTIVE POLYGLYCYLASE TTLL10 ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG100074|UniProtKB=T1ECY4 T1ECY4 20194436 PTHR24355:SF28 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GPRK#P00840 HELRO|EnsemblGenome=HelroG105504|UniProtKB=T1EDW0 T1EDW0 20194762 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG193792|UniProtKB=T1FVC9 T1FVC9 20212775 PTHR23280:SF25 4.1 G PROTEIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG161856|UniProtKB=T1ERZ0 T1ERZ0 20199340 PTHR45873:SF1 DNA POLYMERASE ETA DNA POLYMERASE ETA DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;DNA-directed DNA polymerase activity#GO:0003887 nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;response to radiation#GO:0009314;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;translesion synthesis#GO:0019985 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;replication fork#GO:0005657 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG192792|UniProtKB=T1FUA9 T1FUA9 20212405 PTHR17608:SF4 GENETIC SUPPRESSOR ELEMENT 1 GENETIC SUPPRESSOR ELEMENT 1 HELRO|EnsemblGenome=HelroG63300|UniProtKB=T1FXD7 T1FXD7 20213485 PTHR15036:SF88 PIKACHURIN-LIKE PROTEIN PIKACHURIN signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012;basement membrane#GO:0005604;cell periphery#GO:0071944;cell junction#GO:0030054;extracellular region#GO:0005576 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG133373|UniProtKB=T1EI04 T1EI04 20196204 PTHR24044:SF512 NOTCH LIGAND FAMILY MEMBER PROTEIN LIN-12 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Next#P01103;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120 HELRO|EnsemblGenome=HelroG65162|UniProtKB=T1FY39 T1FY39 20213737 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG169896|UniProtKB=T1F2F1 T1F2F1 20203001 PTHR10792:SF1 60S RIBOSOMAL PROTEIN L24 LARGE RIBOSOMAL SUBUNIT PROTEIN EL24 structural molecule activity#GO:0005198;RNA binding#GO:0003723;mRNA binding#GO:0003729;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG191771|UniProtKB=T1FTA9 T1FTA9 20212056 PTHR12983:SF9 RING FINGER 10 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RNF10 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG76160|UniProtKB=T1G2F9 T1G2F9 20215257 PTHR12022:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 7 generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex III#GO:0045275;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG184659|UniProtKB=T1FLP8 T1FLP8 20209747 PTHR21207:SF2 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED GH16267P-RELATED Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 HELRO|EnsemblGenome=HelroG186311|UniProtKB=T1FNY3 T1FNY3 20210530 PTHR10545:SF29 DIAMINE N-ACETYLTRANSFERASE GH14572P-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080 acetyltransferase#PC00038;transferase#PC00220 HELRO|EnsemblGenome=HelroG184374|UniProtKB=T1FL29 T1FL29 20209528 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185045|UniProtKB=T1FMB8 T1FMB8 20209967 PTHR16461:SF5 TOLL-INTERACTING PROTEIN TOLL-INTERACTING PROTEIN protein binding#GO:0005515;ubiquitin binding#GO:0043130;enzyme binding#GO:0019899;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Toll receptor signaling pathway#P00054>Tollip#P01379 HELRO|EnsemblGenome=HelroG186101|UniProtKB=T1FNN5 T1FNN5 20210432 PTHR11851:SF229 METALLOPROTEASE MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;localization#GO:0051179;protein localization to mitochondrion#GO:0070585;macromolecule localization#GO:0033036 endopeptidase complex#GO:1905369;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;peptidase complex#GO:1905368;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG104475|UniProtKB=T1EDL8 T1EDL8 20194670 PTHR11351:SF104 ACYL-COA DESATURASE DESATURASE 1, ISOFORM A-RELATED iron ion binding#GO:0005506;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;unsaturated fatty acid biosynthetic process#GO:0006636;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG72444|UniProtKB=T1G102 T1G102 20214750 PTHR22838:SF4 WD REPEAT PROTEIN 26-RELATED WD REPEAT-CONTAINING PROTEIN 13 binding#GO:0005488;chromatin binding#GO:0003682 HELRO|EnsemblGenome=HelroG192301|UniProtKB=T1FTT1 T1FTT1 20212228 PTHR15952:SF11 EXPORTIN-T/LOS1 EXPORTIN-T binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;tRNA binding#GO:0000049 nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG89456|UniProtKB=T1G7D1 T1G7D1 20216978 PTHR43591:SF116 METHYLTRANSFERASE 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152 methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG193608|UniProtKB=T1FV64 T1FV64 20212710 PTHR15600:SF42 SACSIN SACSIN_NOV DOMAIN-CONTAINING PROTEIN heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 HELRO|EnsemblGenome=HelroG182785|UniProtKB=T1FIQ4 T1FIQ4 20208703 PTHR20963:SF56 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG186940|UniProtKB=T1FP45 T1FP45 20210592 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;non-membrane spanning protein tyrosine kinase activity#GO:0004715;signaling receptor binding#GO:0005102;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG177398|UniProtKB=T1FBM5 T1FBM5 20206224 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG78026|UniProtKB=T1G369 T1G369 20215517 PTHR11259:SF1 RAS-RELATED GTP BINDING RAG/GTR YEAST RAS-RELATED GTP-BINDING PROTEIN purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168 positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;negative regulation of catabolic process#GO:0009895;positive regulation of TOR signaling#GO:0032008;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to stress#GO:0006950;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;lysosome#GO:0005764;nucleus#GO:0005634;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG112849|UniProtKB=T1EFM6 T1EFM6 20195378 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 nucleic acid biosynthetic process#GO:0141187;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions#GO:0000375;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;localization#GO:0051179;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;establishment of RNA localization#GO:0051236;RNA biosynthetic process#GO:0032774;mRNA transport#GO:0051028;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG188550|UniProtKB=T1FQ41 T1FQ41 20210938 PTHR23236:SF119 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H SPLICEOSOME ASSOCIATED FACTOR 3, U4_U6 RECYCLING PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG168100|UniProtKB=T1F061 T1F061 20202211 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164579|UniProtKB=T1EVL6 T1EVL6 20200616 PTHR23164:SF29 EARLY ENDOSOME ANTIGEN 1 INACTIVE SERINE_THREONINE-PROTEIN KINASE SLOB1-RELATED membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG124437|UniProtKB=T1EH14 T1EH14 20195864 PTHR16007:SF15 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B-LIKE HELRO|EnsemblGenome=HelroG134995|UniProtKB=T1EI66 T1EI66 20196266 PTHR19288:SF46 4-NITROPHENYLPHOSPHATASE-RELATED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG155500|UniProtKB=T1ELI6 T1ELI6 20197436 PTHR18945:SF938 NEUROTRANSMITTER GATED ION CHANNEL PROTON-GATED ION CHANNEL ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG191586|UniProtKB=T1FT38 T1FT38 20211985 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG180766|UniProtKB=T1FG91 T1FG91 20207840 PTHR10627:SF31 SCP160 DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG82463|UniProtKB=T1G4S5 T1G4S5 20216073 PTHR10183:SF379 CALPAIN CALPAIN-A-RELATED protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG186177|UniProtKB=T1FNR9 T1FNR9 20210466 PTHR13486:SF2 TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER SPLICING FACTOR C9ORF78 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HELRO|EnsemblGenome=HelroG180234|UniProtKB=T1FFL5 T1FFL5 20207614 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG185274|UniProtKB=T1FML5 T1FML5 20210064 PTHR10476:SF2 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1B-RELATED establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;macromolecule localization#GO:0033036;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;late endosome to vacuole transport#GO:0045324;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68265|UniProtKB=T1FZC2 T1FZC2 20214170 PTHR10502:SF253 ANNEXIN ANNEXIN phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;phospholipid binding#GO:0005543;anion binding#GO:0043168 membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG76209|UniProtKB=T1G2G8 T1G2G8 20215266 PTHR46473:SF30 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;transmembrane transporter binding#GO:0044325;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;channel regulator activity#GO:0016247;passive transmembrane transporter activity#GO:0022803;ion channel regulator activity#GO:0099106;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;voltage-gated monoatomic ion channel activity#GO:0005244;binding#GO:0005488;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;potassium channel regulator activity#GO:0015459;protein binding#GO:0005515;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;molecular function activator activity#GO:0140677;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG193799|UniProtKB=T1FVD2 T1FVD2 20212778 PTHR12693:SF3 MENIN MENIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription initiation-coupled chromatin remodeling#GO:0045815;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 CCKR signaling map#P06959>MEN1#P07084 HELRO|EnsemblGenome=HelroG121380|UniProtKB=T1EGR7 T1EGR7 20195767 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG112986|UniProtKB=T1EFP2 T1EFP2 20195394 PTHR43651:SF15 1,4-ALPHA-GLUCAN-BRANCHING ENZYME 1,4-ALPHA-GLUCAN-BRANCHING ENZYME glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 polysaccharide metabolic process#GO:0005976;carbohydrate metabolic process#GO:0005975;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;glucan biosynthetic process#GO:0009250;energy reserve metabolic process#GO:0006112;polysaccharide biosynthetic process#GO:0000271;biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;glycogen biosynthetic process#GO:0005978 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 amylase#PC00048 HELRO|EnsemblGenome=HelroG65239|UniProtKB=T1FY49 T1FY49 20213747 PTHR24346:SF74 MAP/MICROTUBULE AFFINITY-REGULATING KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;intracellular signal transduction#GO:0035556;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG74885|UniProtKB=T1G1X1 T1G1X1 20215069 PTHR42879:SF2 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidoreductase#PC00176;reductase#PC00198 HELRO|EnsemblGenome=HelroG76975|UniProtKB=T1G2S1 T1G2S1 20215369 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185624|UniProtKB=T1FN20 T1FN20 20210219 PTHR19857:SF19 MITOCHONDRIAL DIVISION PROTEIN 1-RELATED 26S PROTEASOME REGULATORY SUBUNIT RPN14 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177447|UniProtKB=T1FBQ2 T1FBQ2 20206251 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG180186|UniProtKB=T1FFJ9 T1FFJ9 20207598 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG79879|UniProtKB=T1G3U9 T1G3U9 20215747 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG88257|UniProtKB=T1G707 T1G707 20216854 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG156230|UniProtKB=T1ELT0 T1ELT0 20197530 PTHR32194:SF2 METALLOPROTEASE TLDD PROTEASOME SUBUNIT BETA TYPE-1 catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metalloprotease#PC00153 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG109184|UniProtKB=T1EER1 T1EER1 20195063 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 steroid hydroxylase activity#GO:0008395;binding#GO:0005488;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629;response to chemical#GO:0042221;response to stimulus#GO:0050896;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG84303|UniProtKB=T1G5H3 T1G5H3 20216320 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;myosin binding#GO:0017022 localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 cell junction#GO:0030054;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endosome#GO:0005768;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG107946|UniProtKB=T1EEE2 T1EEE2 20194944 PTHR42884:SF38 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;peptide hormone processing#GO:0016486;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;DPP signaling pathway#P06213>FUR1#P06290;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Activin beta signaling pathway#P06210>FUR1#P06238;DPP-SCW signaling pathway#P06212>FUR1#P06263;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;Endothelin signaling pathway#P00019>furin#P00575;MYO signaling pathway#P06215>FUR1#P06318;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG85671|UniProtKB=T1G612 T1G612 20216509 PTHR21192:SF2 NUCLEAR PROTEIN E3-3 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3 mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG94589|UniProtKB=T1G919 T1G919 20217566 PTHR42886:SF96 RE40534P-RELATED 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ABHD5 carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;acyltransferase activity#GO:0016746;hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;organophosphate biosynthetic process#GO:0090407 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG112541|UniProtKB=T1EFK6 T1EFK6 20195358 PTHR45735:SF2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG190854|UniProtKB=T1FSD2 T1FSD2 20211729 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183162|UniProtKB=T1FJ86 T1FJ86 20208885 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107921|UniProtKB=T1EED9 T1EED9 20194941 PTHR45752:SF198 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91957|UniProtKB=T1G8A7 T1G8A7 20217304 PTHR23113:SF374 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-GEF DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;Ras protein signal transduction#GO:0007265;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG73579|UniProtKB=T1G1G0 T1G1G0 20214908 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG187099|UniProtKB=T1FP69 T1FP69 20210616 PTHR22754:SF45 DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED DISCO-INTERACTING PROTEIN 2 ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG193918|UniProtKB=T1FVH1 T1FVH1 20212817 PTHR23254:SF15 EIF4G DOMAIN PROTEIN POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1 translation regulator activity#GO:0045182 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of translational initiation#GO:0006446;post-transcriptional regulation of gene expression#GO:0010608 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189514|UniProtKB=T1FR43 T1FR43 20211290 PTHR23078:SF3 VESICULAR-FUSION PROTEIN NSF VESICLE-FUSING ATPASE hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;protein localization to cell periphery#GO:1990778;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;intra-Golgi vesicle-mediated transport#GO:0006891;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 Synaptic vesicle trafficking#P05734>NSF#P05774;Ionotropic glutamate receptor pathway#P00037>NSF#P01020 HELRO|EnsemblGenome=HelroG90524|UniProtKB=T1G7S6 T1G7S6 20217123 PTHR24243:SF240 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG166132|UniProtKB=T1EXU0 T1EXU0 20201390 PTHR24054:SF28 CASEIN KINASE II SUBUNIT ALPHA NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Parkinson disease#P00049>Casein kinase II#P01236;Wnt signaling pathway#P00057>Casein Kinase 2#P01459 HELRO|EnsemblGenome=HelroG153365|UniProtKB=T1EL50 T1EL50 20197305 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG81183|UniProtKB=T1G4A8 T1G4A8 20215906 PTHR11255:SF125 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE THETA transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 membrane#GO:0016020;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;kinase#PC00137 HELRO|EnsemblGenome=HelroG161970|UniProtKB=T1ES38 T1ES38 20199388 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77371|UniProtKB=T1G2W9 T1G2W9 20215417 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;ribose phosphate biosynthetic process#GO:0046390;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG72856|UniProtKB=T1G161 T1G161 20214809 PTHR10582:SF28 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN NANCHUNG, ISOFORM B channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG88474|UniProtKB=T1G730 T1G730 20216877 PTHR23504:SF14 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 SOLUTE CARRIER FAMILY 67 MEMBER A2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG180047|UniProtKB=T1FFE2 T1FFE2 20207541 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG74951|UniProtKB=T1G1Y4 T1G1Y4 20215082 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG190028|UniProtKB=T1FRL9 T1FRL9 20211466 PTHR22619:SF1 ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HELRO|EnsemblGenome=HelroG159594|UniProtKB=T1EP79 T1EP79 20198379 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 HELRO|EnsemblGenome=HelroG74056|UniProtKB=T1G1L9 T1G1L9 20214967 PTHR21625:SF0 NYD-SP28 PROTEIN DYNEIN REGULATORY COMPLEX SUBUNIT 2 plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cilium or flagellum-dependent cell motility#GO:0001539;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;regulation of microtubule-based movement#GO:0060632;cell motility#GO:0048870;regulation of cellular process#GO:0050794 plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG91618|UniProtKB=T1G863 T1G863 20217260 PTHR23349:SF42 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BHLH DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185778|UniProtKB=T1FNA1 T1FNA1 20210298 PTHR24073:SF1241 DRAB5-RELATED RAB FAMILY GTPASE ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG168671|UniProtKB=T1F0U6 T1F0U6 20202446 PTHR12429:SF6 NEURALIZED PROTEIN NEURALIZED transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 regulation of cell communication#GO:0010646;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of biological process#GO:0050789;protein transport#GO:0015031;localization#GO:0051179;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;import into cell#GO:0098657;regulation of response to stimulus#GO:0048583;transport#GO:0006810 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191241|UniProtKB=T1FSS3 T1FSS3 20211870 PTHR12081:SF18 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 p53 pathway feedback loops 2#P04398>E2F-1#P04652;Cell cycle#P00013>E2F#P00488;p53 pathway#P00059>E2F-1#P04627 HELRO|EnsemblGenome=HelroG123271|UniProtKB=T1EGX4 T1EGX4 20195824 PTHR11579:SF9 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG76269|UniProtKB=T1G2H6 T1G2H6 20215274 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215 trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007 postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG86393|UniProtKB=T1G6B6 T1G6B6 20216613 PTHR11210:SF2 RING BOX E3 UBIQUITIN-PROTEIN LIGASE RBX1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163959|UniProtKB=T1EUN9 T1EUN9 20200289 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG127849|UniProtKB=T1EHI7 T1EHI7 20196037 PTHR10252:SF79 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DNA POLYMERASE EPSILON SUBUNIT 4 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260;nucleobase-containing compound metabolic process#GO:0006139 chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ISWI-type complex#GO:0031010;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;membraneless organelle#GO:0043228;epsilon DNA polymerase complex#GO:0008622;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG189203|UniProtKB=T1FQS4 T1FQS4 20211171 PTHR24223:SF485 ATP-BINDING CASSETTE SUB-FAMILY C ABC-TYPE GLUTATHIONE-S-CONJUGATE TRANSPORTER cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG104310|UniProtKB=T1EDK9 T1EDK9 20194661 PTHR22870:SF155 REGULATOR OF CHROMOSOME CONDENSATION E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG173384|UniProtKB=T1F6R3 T1F6R3 20204512 PTHR14647:SF87 GALACTOSE-3-O-SULFOTRANSFERASE GALACTOSYLCERAMIDE SULFOTRANSFERASE-LIKE transferase#PC00220 HELRO|EnsemblGenome=HelroG104323|UniProtKB=T1EDL0 T1EDL0 20194662 PTHR13532:SF3 FAMILY NOT NAMED INTEGRATOR COMPLEX SUBUNIT 14 HELRO|EnsemblGenome=HelroG191624|UniProtKB=T1FT52 T1FT52 20211999 PTHR15431:SF4 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN PROTEIN TONNEAU 1A-RELATED HELRO|EnsemblGenome=HelroG79745|UniProtKB=T1G3S8 T1G3S8 20215726 PTHR11473:SF43 AROMATIC AMINO ACID HYDROXYLASE TRYPTOPHAN 5-HYDROXYLASE 2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 phenol-containing compound metabolic process#GO:0018958;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;phenol-containing compound biosynthetic process#GO:0046189;biosynthetic process#GO:0009058;serotonin biosynthetic process#GO:0042427;metabolic process#GO:0008152;serotonin metabolic process#GO:0042428 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 5-Hydroxytryptamine biosynthesis#P04371>Tryptophan hydroxylase#P04399 HELRO|EnsemblGenome=HelroG105135|UniProtKB=T1EDR2 T1EDR2 20194714 PTHR20952:SF0 ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1 cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum membrane organization#GO:0090158;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum tubular network organization#GO:0071786;cellular component assembly#GO:0022607;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG186886|UniProtKB=T1FP44 T1FP44 20210591 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096;non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;signaling receptor binding#GO:0005102;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515 enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG191855|UniProtKB=T1FTD1 T1FTD1 20212078 PTHR10825:SF75 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT POLYCOMB GROUP PROTEIN PSC binding#GO:0005488;chromatin binding#GO:0003682 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;PcG protein complex#GO:0031519;nucleus#GO:0005634;protein-containing complex#GO:0032991 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG158300|UniProtKB=T1EML9 T1EML9 20197819 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163427|UniProtKB=T1EU12 T1EU12 20200062 PTHR46109:SF1 PROTEIN LIN-28 PROTEIN LIN-28 HOMOLOG mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;pre-miRNA processing#GO:0031054;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108666|UniProtKB=T1EEL3 T1EEL3 20195015 PTHR24349:SF561 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 2 enzyme binding#GO:0019899;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;kinase activity#GO:0016301;transferase activity#GO:0016740;calmodulin binding#GO:0005516;mitogen-activated protein kinase binding#GO:0051019;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Angiogenesis#P00005>MAPKAPK2/3#P00244;Ras Pathway#P04393>MAPKAP#P04564;VEGF signaling pathway#P00056>MAPKAPK2/3#P01415;PDGF signaling pathway#P00047>MAPKAPK2#P01157 HELRO|EnsemblGenome=HelroG158732|UniProtKB=T1EN61 T1EN61 20198011 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192951|UniProtKB=T1FUG3 T1FUG3 20212459 PTHR21528:SF0 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;organophosphate metabolic process#GO:0019637;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG180445|UniProtKB=T1FFX3 T1FFX3 20207722 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG126387|UniProtKB=T1EH97 T1EH97 20195947 PTHR17453:SF0 SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 protein targeting#GO:0006605;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;cellular component assembly#GO:0022607;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;protein targeting to ER#GO:0045047;protein-containing complex organization#GO:0043933;protein targeting to membrane#GO:0006612;SRP-dependent cotranslational protein targeting to membrane#GO:0006614 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG192245|UniProtKB=T1FTR5 T1FTR5 20212212 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG168132|UniProtKB=T1F073 T1F073 20202223 PTHR24118:SF99 POTE ANKYRIN DOMAIN CHARON membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG175437|UniProtKB=T1F995 T1F995 20205394 PTHR33936:SF24 PROTEIN CBG17840 C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92464|UniProtKB=T1G8G7 T1G8G7 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;calcium ion homeostasis#GO:0055074;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG192218|UniProtKB=T1FTQ2 T1FTQ2 20212199 PTHR23427:SF15 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 1 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG145703|UniProtKB=T1EJM2 T1EJM2 20196772 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189599|UniProtKB=T1FR68 T1FR68 20211315 PTHR31840:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 97 COILED-COIL DOMAIN-CONTAINING PROTEIN 97 HELRO|EnsemblGenome=HelroG84464|UniProtKB=T1G5I9 T1G5I9 20216336 PTHR23086:SF150 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 kinase#PC00137;transferase#PC00220 HELRO|EnsemblGenome=HelroG66424|UniProtKB=T1FYL0 T1FYL0 20213908 PTHR13680:SF5 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 iron-sulfur cluster binding#GO:0051536;transaminase activity#GO:0008483;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HELRO|EnsemblGenome=HelroG177702|UniProtKB=T1FC38 T1FC38 20206387 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188955|UniProtKB=T1FQI1 T1FQI1 20211078 PTHR10075:SF111 BASIGIN RELATED RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MOSPTP-1-RELATED cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG62224|UniProtKB=T1FWX3 T1FWX3 20213321 PTHR43475:SF1 METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 proteinogenic amino acid metabolic process#GO:0170039;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;sulfur compound metabolic process#GO:0006790;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;purine-containing compound metabolic process#GO:0072521;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278 isomerase#PC00135 HELRO|EnsemblGenome=HelroG82787|UniProtKB=T1G4W7 T1G4W7 20216115 PTHR24078:SF553 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 13 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG179295|UniProtKB=T1FL79 T1FL79 20207229 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185543|UniProtKB=T1FMY6 T1FMY6 20210185 PTHR23139:SF9 RNA-BINDING PROTEIN SPLICING FACTOR U2AF 65 KDA SUBUNIT nucleic acid binding#GO:0003676;binding#GO:0005488;pre-mRNA binding#GO:0036002;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;nuclear speck#GO:0016607;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684 HELRO|EnsemblGenome=HelroG125499|UniProtKB=T1EH63 T1EH63 20195913 PTHR24393:SF190 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185807|UniProtKB=T1FNB4 T1FNB4 20210311 PTHR46447:SF1 INTERLEUKIN ENHANCER-BINDING FACTOR INTERLEUKIN ENHANCER-BINDING FACTOR 2 double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;RNA binding#GO:0003723 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG157299|UniProtKB=T1EM90 T1EM90 20197690 PTHR12398:SF20 PROTEIN PHOSPHATASE INHIBITOR PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2 phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 phosphatase inhibitor#PC00183 HELRO|EnsemblGenome=HelroG106040|UniProtKB=T1EDZ5 T1EDZ5 20194797 PTHR22872:SF11 BTK-BINDING PROTEIN-RELATED BTB DOMAIN-CONTAINING PROTEIN transport#GO:0006810;transmembrane transport#GO:0055085;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 HELRO|EnsemblGenome=HelroG81831|UniProtKB=T1G4J3 T1G4J3 20215991 PTHR23264:SF35 NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG185263|UniProtKB=T1FMK8 T1FMK8 20210057 PTHR44140:SF2 LD25575P LD25575P protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG177609|UniProtKB=T1FBY0 T1FBY0 20206329 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166018|UniProtKB=T1EXL7 T1EXL7 20201317 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG183511|UniProtKB=T1FJR8 T1FJR8 20209067 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177164|UniProtKB=T1FBA8 T1FBA8 20206107 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN anatomical structure development#GO:0048856;developmental process#GO:0032502 HELRO|EnsemblGenome=HelroG168627|UniProtKB=T1F0T3 T1F0T3 20202433 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG164869|UniProtKB=T1EVW5 T1EVW5 20200715 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG161135|UniProtKB=T1ER48 T1ER48 20199048 PTHR22255:SF11 LP06548P G PROTEIN HELRO|EnsemblGenome=HelroG124292|UniProtKB=T1EH08 T1EH08 20195858 PTHR12121:SF105 CARBON CATABOLITE REPRESSOR PROTEIN 4 PROTEIN ANGEL nuclease activity#GO:0004518;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;mRNA binding#GO:0003729;binding#GO:0005488;mRNA 3'-UTR binding#GO:0003730;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;RNA nuclease activity#GO:0004540;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;mitochondrial RNA 3'-end processing#GO:0000965;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial RNA processing#GO:0000963;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;catabolic process#GO:0009056;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of mRNA metabolic process#GO:1903313;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013 mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG162502|UniProtKB=T1ESR4 T1ESR4 20199614 PTHR19327:SF0 GOLGIN GOLGIN SUBFAMILY A MEMBER 4 protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme binding#GO:0019899;binding#GO:0005488 Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG158836|UniProtKB=T1ENB6 T1ENB6 20198066 PTHR22744:SF17 HELIX LOOP HELIX PROTEIN 21-RELATED BTB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72015|UniProtKB=T1G0U1 T1G0U1 20214689 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER FIBROPELLIN-1-LIKE protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG131017|UniProtKB=T1EHV0 T1EHV0 20196150 PTHR24346:SF119 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE SIK3 HOMOLOG-RELATED protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186617|UniProtKB=T1FP17 T1FP17 20210564 PTHR24067:SF392 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;response to stress#GO:0006950;cellular process#GO:0009987;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;membraneless organelle#GO:0043228;chromatin#GO:0000785;chromosome#GO:0005694;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG104748|UniProtKB=T1EDN5 T1EDN5 20194687 PTHR45618:SF9 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL 2-OXOGLUTARATE_MALATE CARRIER PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG72278|UniProtKB=T1G0X9 T1G0X9 20214727 PTHR35577:SF2 CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED DYNEIN HEAVY CHAIN HELRO|EnsemblGenome=HelroG62703|UniProtKB=T1FX39 T1FX39 20213387 PTHR19855:SF39 WD40 REPEAT PROTEIN 12, 37 SI:CH73-142C19.1 HELRO|EnsemblGenome=HelroG80342|UniProtKB=T1G3Z7 T1G3Z7 20215795 PTHR12436:SF39 80 KDA MCM3-ASSOCIATED PROTEIN GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transcription export complex 2#GO:0070390;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181252|UniProtKB=T1FGS9 T1FGS9 20208028 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111791|UniProtKB=T1EFE7 T1EFE7 20195299 PTHR11373:SF4 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE FALTEN, ISOFORM B catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 purine nucleotide catabolic process#GO:0006195;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;purine-containing compound metabolic process#GO:0072521;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG180413|UniProtKB=T1FFW6 T1FFW6 20207715 PTHR34921:SF1 MEIOTIC RECOMBINATION PROTEIN REC114 MEIOTIC RECOMBINATION PROTEIN REC114 HELRO|EnsemblGenome=HelroG166404|UniProtKB=T1EY34 T1EY34 20201484 PTHR12773:SF0 UPF0315 PROTEIN-RELATED MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;methyltransferase complex#GO:0034708 HELRO|EnsemblGenome=HelroG192851|UniProtKB=T1FUC9 T1FUC9 20212425 PTHR10671:SF112 EPITHELIAL MEMBRANE PROTEIN-RELATED SUBFAMILY NOT NAMED cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG170619|UniProtKB=T1F391 T1F391 20203290 PTHR12356:SF19 NUCLEAR MOVEMENT PROTEIN NUDC NUDC DOMAIN-CONTAINING PROTEIN 3 gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG162034|UniProtKB=T1ES61 T1ES61 20199411 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG186223|UniProtKB=T1FNU1 T1FNU1 20210488 PTHR43153:SF1 ELECTRON TRANSFER FLAVOPROTEIN ALPHA ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;lipid modification#GO:0030258 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG63207|UniProtKB=T1FXC3 T1FXC3 20213471 PTHR24390:SF222 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG190341|UniProtKB=T1FRX2 T1FRX2 20211569 PTHR46218:SF4 LASP LIM AND SH3 DOMAIN PROTEIN LASP protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161 HELRO|EnsemblGenome=HelroG171047|UniProtKB=T1F3R0 T1F3R0 20203459 PTHR12751:SF18 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 2 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG188532|UniProtKB=T1FQ36 T1FQ36 20210933 PTHR21497:SF24 UBIQUITIN LIGASE E3 ALPHA-RELATED E3 UBIQUITIN-PROTEIN LIGASE UBR1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG95052|UniProtKB=T1G943 T1G943 20217590 PTHR11255:SF54 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE EPSILON catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;primary metabolic process#GO:0044238;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486 membrane#GO:0016020;cellular anatomical structure#GO:0110165 kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182183|UniProtKB=T1FHW1 T1FHW1 20208410 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180568|UniProtKB=T1FG20 T1FG20 20207769 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG187446|UniProtKB=T1FP98 T1FP98 20210645 PTHR11024:SF3 NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER NUCLEOPORIN SEH1 regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;response to starvation#GO:0042594;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular response to amino acid starvation#GO:0034198;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;positive regulation of TORC1 signaling#GO:1904263;response to nutrient levels#GO:0031667;regulation of TORC1 signaling#GO:1903432;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267 membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;Seh1-associated complex#GO:0035859;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear pore outer ring#GO:0031080;nucleus#GO:0005634;organelle envelope#GO:0031967 transporter#PC00227 HELRO|EnsemblGenome=HelroG90783|UniProtKB=T1G7W3 T1G7W3 20217160 PTHR13117:SF5 ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED MAN(5)GLCNAC(2)-PP-DOLICHOL TRANSLOCATION PROTEIN RFT1 transport#GO:0006810;lipid localization#GO:0010876;regulation of membrane lipid distribution#GO:0097035;regulation of biological quality#GO:0065008;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;macromolecule localization#GO:0033036;cellular component organization#GO:0016043;membrane organization#GO:0061024;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid transport#GO:0006869 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HELRO|EnsemblGenome=HelroG157204|UniProtKB=T1EM81 T1EM81 20197681 PTHR23249:SF15 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 intracellular protein-containing complex#GO:0140535;TRAPP complex#GO:0030008;vesicle tethering complex#GO:0099023;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG73589|UniProtKB=T1G1G2 T1G1G2 20214910 PTHR48025:SF28 OS02G0815200 PROTEIN RRM DOMAIN-CONTAINING PROTEIN RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG77531|UniProtKB=T1G2Z4 T1G2Z4 20215442 PTHR19229:SF275 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626 lipid transport#GO:0006869;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;lipid localization#GO:0010876;macromolecule localization#GO:0033036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG185820|UniProtKB=T1FNC0 T1FNC0 20210317 PTHR11863:SF241 STEROL DESATURASE FATTY ACID HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 oxidase#PC00175 HELRO|EnsemblGenome=HelroG185962|UniProtKB=T1FNH8 T1FNH8 20210375 PTHR24250:SF50 CHYMOTRYPSIN-RELATED EPITHELIAL SERINE PROTEASE serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG175906|UniProtKB=T1F9V2 T1F9V2 20205601 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181653|UniProtKB=T1FH73 T1FH73 20208172 PTHR24247:SF202 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268 dendritic tree#GO:0097447;dendrite#GO:0030425;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG165663|UniProtKB=T1EX53 T1EX53 20201153 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG110003|UniProtKB=T1EEY2 T1EEY2 20195134 PTHR45832:SF16 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED STE20-RELATED KINASE ADAPTER PROTEIN STLK HELRO|EnsemblGenome=HelroG191290|UniProtKB=T1FSU6 T1FSU6 20211893 PTHR24202:SF53 E3 UBIQUITIN-PROTEIN LIGASE MIB2 E3 UBIQUITIN-PROTEIN LIGASE MIB1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;Notch signaling pathway#GO:0007219;import into cell#GO:0098657;signal transduction#GO:0007165;cellular process#GO:0009987;protein ubiquitination#GO:0016567;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;cell communication#GO:0007154;localization#GO:0051179;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;protein modification process#GO:0036211;primary metabolic process#GO:0044238;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;endocytosis#GO:0006897 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG121515|UniProtKB=T1EGS2 T1EGS2 20195772 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190627|UniProtKB=T1FS55 T1FS55 20211652 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG178716|UniProtKB=T1FDM2 T1FDM2 20206921 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79801|UniProtKB=T1G3T5 T1G3T5 20215733 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 23 HELRO|EnsemblGenome=HelroG62692|UniProtKB=T1FX36 T1FX36 20213384 PTHR12663:SF0 ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191688|UniProtKB=T1FT76 T1FT76 20212023 PTHR19134:SF576 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG83027|UniProtKB=T1G4Z3 T1G4Z3 20216141 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG167265|UniProtKB=T1EZ69 T1EZ69 20201869 PTHR46437:SF1 MORN REPEAT-CONTAINING PROTEIN 5 MORN REPEAT-CONTAINING PROTEIN 5 HELRO|EnsemblGenome=HelroG115556|UniProtKB=T1EG92 T1EG92 20195594 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;filopodium assembly#GO:0046847;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cell projection organization#GO:0030030;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG166598|UniProtKB=T1EYA3 T1EYA3 20201553 PTHR24217:SF0 PUTATIVE-RELATED SYNAPTOPODIN 2-LIKE PROTEIN cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein binding#GO:0005515 positive regulation of organelle organization#GO:0010638;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of intracellular signal transduction#GO:1902531;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of actin filament bundle assembly#GO:0032231;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of actin filament bundle assembly#GO:0032233;regulation of response to stimulus#GO:0048583;regulation of actin filament-based process#GO:0032970;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin filament organization#GO:0110053;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 contractile muscle fiber#GO:0043292;Z disc#GO:0030018;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;I band#GO:0031674;cytoskeleton#GO:0005856;sarcomere#GO:0030017;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG181593|UniProtKB=T1FH52 T1FH52 20208151 PTHR21580:SF28 SHIPPO-1-RELATED SPERM-TAIL PG-RICH REPEAT FAMILY PROTEIN intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226 structural protein#PC00211 HELRO|EnsemblGenome=HelroG64765|UniProtKB=T1FXY7 T1FXY7 20213685 PTHR13054:SF2 DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER PROTEIN DGCR6 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG165816|UniProtKB=T1EXB5 T1EXB5 20201215 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG142283|UniProtKB=T1EJ53 T1EJ53 20196603 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 19-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG173331|UniProtKB=T1F6P4 T1F6P4 20204493 PTHR22198:SF1 FERM DOMAIN-CONTAINING PROTEIN DUF7153 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158749|UniProtKB=T1EN72 T1EN72 20198022 PTHR21501:SF1 PROTEIN FAM-161 PROTEIN FAM-161 plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 HELRO|EnsemblGenome=HelroG194017|UniProtKB=T1FVK6 T1FVK6 20212852 PTHR13723:SF327 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PLAC DOMAIN-CONTAINING PROTEIN peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG173412|UniProtKB=T1F6S6 T1F6S6 20204525 PTHR23353:SF36 RAB-GAP/TBC-RELATED LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG181266|UniProtKB=T1FGT5 T1FGT5 20208034 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG189384|UniProtKB=T1FR05 T1FR05 20211252 PTHR46582:SF1 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 HELRO|EnsemblGenome=HelroG133652|UniProtKB=T1EI21 T1EI21 20196221 PTHR24416:SF660 TYROSINE-PROTEIN KINASE RECEPTOR RET ONCOGENE, ISOFORM A phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG105717|UniProtKB=T1EDX2 T1EDX2 20194774 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 HELRO|EnsemblGenome=HelroG164007|UniProtKB=T1EUR3 T1EUR3 20200313 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG88310|UniProtKB=T1G715 T1G715 20216862 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG169974|UniProtKB=T1F2H9 T1F2H9 20203029 PTHR23113:SF376 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR C guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG174974|UniProtKB=T1F8N8 T1F8N8 20205187 PTHR33137:SF48 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED MATH DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG70801|UniProtKB=T1G0C4 T1G0C4 20214522 PTHR11347:SF198 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE, ISOFORM I phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646 hydrolase#PC00121;phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG70246|UniProtKB=T1G038 T1G038 20214436 PTHR10155:SF16 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 2-LIKE PROTEIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 signal transduction#GO:0007165;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;response to cytokine#GO:0034097;response to chemical#GO:0042221;negative regulation of response to stimulus#GO:0048585;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;cytokine-mediated signaling pathway#GO:0019221;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;response to peptide#GO:1901652;cell communication#GO:0007154 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG89194|UniProtKB=T1G7A0 T1G7A0 20216947 PTHR10509:SF14 O-METHYLTRANSFERASE-RELATED CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;catalytic activity#GO:0003824 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG180983|UniProtKB=T1FGH8 T1FGH8 20207927 PTHR21227:SF0 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;lyase activity#GO:0016829;catalytic activity, acting on a tRNA#GO:0140101;nuclease activity#GO:0004518 tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 DNA metabolism protein#PC00009;endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG173209|UniProtKB=T1F6K6 T1F6K6 20204455 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG102324|UniProtKB=T1ED95 T1ED95 20194547 PTHR12655:SF10 ACYL-COA THIOESTERASE ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL hydrolase activity#GO:0016787;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;acyl-CoA hydrolase activity#GO:0016289;catalytic activity#GO:0003824;deacylase activity#GO:0160215;fatty acyl-CoA hydrolase activity#GO:0047617 small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;hydrolase#PC00121;esterase#PC00097 HELRO|EnsemblGenome=HelroG65652|UniProtKB=T1FYB1 T1FYB1 20213809 PTHR11783:SF100 SULFOTRANSFERASE SULT SULFOTRANSFERASE 4, ISOFORM A catalytic activity#GO:0003824;transferase activity#GO:0016740;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178702|UniProtKB=T1FDL5 T1FDL5 20206914 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG110647|UniProtKB=T1EF39 T1EF39 20195191 PTHR11129:SF1 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737 transferase#PC00220;acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG83112|UniProtKB=T1G504 T1G504 20216152 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM K-RELATED ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG161981|UniProtKB=T1ES43 T1ES43 20199393 PTHR12062:SF0 N-ACETYLGLUCOSAMINYLTRANSFERASE VI MGAT4 CONSERVED REGION DOMAIN-CONTAINING PROTEIN glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 transferase#PC00220 HELRO|EnsemblGenome=HelroG81974|UniProtKB=T1G4L1 T1G4L1 20216009 PTHR13376:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium assembly#GO:0060271;cellular component organization#GO:0016043 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intraciliary transport particle B#GO:0030992;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intraciliary transport particle#GO:0030990;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG189308|UniProtKB=T1FQY0 T1FQY0 20211227 PTHR14568:SF8 TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2 TRANSMEMBRANE 6 SUPERFAMILY MEMBER 1-LIKE HELRO|EnsemblGenome=HelroG181715|UniProtKB=T1FH90 T1FH90 20208189 PTHR20963:SF56 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG72797|UniProtKB=T1G158 T1G158 20214806 PTHR19308:SF14 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN START DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG156082|UniProtKB=T1ELR6 T1ELR6 20197516 PTHR23065:SF11 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 SYNDAPIN, ISOFORM C phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987 intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG158518|UniProtKB=T1EMW5 T1EMW5 20197915 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG92006|UniProtKB=T1G8B3 T1G8B3 20217310 PTHR24115:SF191 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF9 hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG185644|UniProtKB=T1FN31 T1FN31 20210230 PTHR12592:SF0 ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185390|UniProtKB=T1FMR4 T1FMR4 20210113 PTHR11465:SF9 CATALASE CATALASE peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity#GO:0016491;binding#GO:0005488;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 hydrogen peroxide metabolic process#GO:0042743;response to chemical#GO:0042221;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular process#GO:0009987;response to stress#GO:0006950;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;response to oxygen-containing compound#GO:1901700;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;mitochondrion#GO:0005739 peroxidase#PC00180 HELRO|EnsemblGenome=HelroG123629|UniProtKB=T1EGY3 T1EGY3 20195833 PTHR45939:SF5 PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED PEROXISOMAL MEMBRANE PROTEIN PMP34 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG192511|UniProtKB=T1FU15 T1FU15 20212311 PTHR11616:SF340 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;glycine transmembrane transporter activity#GO:0015187;metal ion transmembrane transporter activity#GO:0046873;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081 import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;amino acid transport#GO:0006865;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;glycine transport#GO:0015816;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG75560|UniProtKB=T1G265 T1G265 20215163 PTHR24068:SF567 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG164051|UniProtKB=T1EUU1 T1EUU1 20200341 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63219|UniProtKB=T1FXC5 T1FXC5 20213473 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG67024|UniProtKB=T1FYV2 T1FYV2 20214000 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020 ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG183713|UniProtKB=T1FK35 T1FK35 20209184 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG116221|UniProtKB=T1EGD5 T1EGD5 20195637 PTHR11076:SF33 DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER DNA POLYMERASE KAPPA DNA-directed DNA polymerase activity#GO:0003887;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;translesion synthesis#GO:0019985;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA synthesis involved in DNA replication#GO:0090592;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG158578|UniProtKB=T1EMY8 T1EMY8 20197938 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173449|UniProtKB=T1F6U6 T1F6U6 20204545 PTHR45636:SF58 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;sensory organ development#GO:0007423;nervous system development#GO:0007399;head development#GO:0060322;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG130363|UniProtKB=T1EHT7 T1EHT7 20196137 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;DNA binding#GO:0003677;histone acetyltransferase activity#GO:0004402;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;binding#GO:0005488;acetyltransferase activity#GO:0016407;transcription regulator activity#GO:0140110;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transcription regulator complex#GO:0005667;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;DPP-SCW signaling pathway#P06212>NEJ#P06260;p53 pathway#P00059>CBP#P04623;Huntington disease#P00029>CBP#P00777;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;DPP signaling pathway#P06213>NEJ#P06284;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295 HELRO|EnsemblGenome=HelroG160388|UniProtKB=T1EQ70 T1EQ70 20198720 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176473|UniProtKB=T1FAJ5 T1FAJ5 20205844 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endosome membrane#GO:0010008;endosome#GO:0005768;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG180676|UniProtKB=T1FG56 T1FG56 20207805 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG91636|UniProtKB=T1G868 T1G868 20217265 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023 cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;cyclic nucleotide biosynthetic process#GO:0009190;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG191968|UniProtKB=T1FTG7 T1FTG7 20212114 PTHR32083:SF0 CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58 intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 structural protein#PC00211 HELRO|EnsemblGenome=HelroG103356|UniProtKB=T1EDF8 T1EDF8 20194610 PTHR13659:SF5 AUTOSOMAL HIGHLY CONSERVED PROTEIN PROTEIN FAM8A1 HELRO|EnsemblGenome=HelroG155397|UniProtKB=T1ELI2 T1ELI2 20197432 PTHR10188:SF50 L-ASPARAGINASE N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;lysosome#GO:0005764;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165229|UniProtKB=T1EWG8 T1EWG8 20200918 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133 HELRO|EnsemblGenome=HelroG187155|UniProtKB=T1FP73 T1FP73 20210620 PTHR45758:SF20 MITOFERRIN-1-RELATED MITOFERRIN-2 monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;iron ion transmembrane transporter activity#GO:0005381;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;iron ion transmembrane transport#GO:0034755;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;transport#GO:0006810 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;organelle envelope#GO:0031967 HELRO|EnsemblGenome=HelroG67925|UniProtKB=T1FZ78 T1FZ78 20214126 PTHR22749:SF14 RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE RIBOFLAVIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;ribonucleotide metabolic process#GO:0009259;nucleoside monophosphate biosynthetic process#GO:0009124;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;flavin-containing compound metabolic process#GO:0042726;nucleobase-containing small molecule metabolic process#GO:0055086 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Flavin biosynthesis#P02741>FAD synthetase#P02936;Flavin biosynthesis#P02741>Riboflavin kinase#P02934 HELRO|EnsemblGenome=HelroG163910|UniProtKB=T1EUL9 T1EUL9 20200269 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG69342|UniProtKB=T1FZT5 T1FZT5 20214333 PTHR11947:SF3 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69468|UniProtKB=T1FZV6 T1FZV6 20214354 PTHR21713:SF4 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED GH09281P-RELATED localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG158755|UniProtKB=T1EN77 T1EN77 20198027 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165713|UniProtKB=T1EX73 T1EX73 20201173 PTHR46680:SF3 NF-KAPPA-B INHIBITOR ALPHA NF-KAPPA-B INHIBITOR CACTUS protein sequestering activity#GO:0140311;binding#GO:0005488;transcription factor binding#GO:0008134;molecular sequestering activity#GO:0140313;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of canonical NF-kappaB signal transduction#GO:0043122;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of cellular process#GO:0050794 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Toll pathway-drosophila#P06217>CACT#P06342 HELRO|EnsemblGenome=HelroG164327|UniProtKB=T1EV93 T1EV93 20200493 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162538|UniProtKB=T1EST4 T1EST4 20199634 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 vesicle#GO:0031982;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG141355|UniProtKB=T1EJ33 T1EJ33 20196583 PTHR24416:SF640 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN VER-1-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG70034|UniProtKB=T1G017 T1G017 20214415 PTHR20935:SF0 PHOSPHOGLYCERATE MUTASE-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;positive regulation of developmental process#GO:0051094;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of mitochondrial fission#GO:0090140;positive regulation of mitochondrial fission#GO:0090141;regulation of developmental process#GO:0050793;regulation of organelle organization#GO:0033043;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of mitochondrion organization#GO:0010821;positive regulation of cellular process#GO:0048522 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 isomerase#PC00135;mutase#PC00160 HELRO|EnsemblGenome=HelroG153376|UniProtKB=T1EL59 T1EL59 20197309 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG84668|UniProtKB=T1G5L6 T1G5L6 20216363 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG100335|UniProtKB=T1ECZ2 T1ECZ2 20194444 PTHR13504:SF34 FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145 PROTEIN ADENYLYLTRANSFERASE FICD catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG97048|UniProtKB=T1G9F1 T1G9F1 20217698 PTHR10680:SF36 PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE 2 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Vasopressin synthesis#P04395>Amidating Enzyme#P04599 HELRO|EnsemblGenome=HelroG176277|UniProtKB=T1FAD0 T1FAD0 20205779 PTHR23302:SF43 TRANSMEMBRANE CHANNEL-RELATED TMC DOMAIN-CONTAINING PROTEIN passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HELRO|EnsemblGenome=HelroG186048|UniProtKB=T1FNL4 T1FNL4 20210411 PTHR23138:SF94 RAN BINDING PROTEIN RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;intracellular transport#GO:0046907;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194166|UniProtKB=T1FVR8 T1FVR8 20212914 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG83547|UniProtKB=T1G570 T1G570 20216218 PTHR45782:SF4 MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 protein-containing complex organization#GO:0043933;mitochondrial ribosome assembly#GO:0061668;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;ribosomal large subunit assembly#GO:0000027;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component assembly#GO:0022607;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;membraneless organelle assembly#GO:0140694;mitochondrial large ribosomal subunit assembly#GO:1902775;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG173809|UniProtKB=T1F792 T1F792 20204691 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67592|UniProtKB=T1FZ27 T1FZ27 20214075 PTHR13129:SF4 VPRBP PROTEIN-RELATED PROTEIN MAHJONG cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HELRO|EnsemblGenome=HelroG89801|UniProtKB=T1G7H8 T1G7H8 20217025 PTHR10827:SF98 RETICULOCALBIN 45 KDA CALCIUM-BINDING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 calmodulin-related#PC00061;calcium-binding protein#PC00060 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830 HELRO|EnsemblGenome=HelroG135540|UniProtKB=T1EI94 T1EI94 20196294 PTHR48112:SF44 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN DSP1 chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG124980|UniProtKB=T1EH37 T1EH37 20195887 PTHR13308:SF40 NEDD4-BINDING PROTEIN 2-LIKE 1 ATP-BINDING PROTEIN HELRO|EnsemblGenome=HelroG175117|UniProtKB=T1F8V8 T1F8V8 20205257 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR endosomal transport#GO:0016197;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endosome#GO:0005768;endosome membrane#GO:0010008;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG90523|UniProtKB=T1G7S5 T1G7S5 20217122 PTHR48027:SF18 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG91560|UniProtKB=T1G854 T1G854 20217251 PTHR13363:SF6 RING FINGER AND SRY DOMAIN-CONTAINING RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159478|UniProtKB=T1EP29 T1EP29 20198329 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172769|UniProtKB=T1F5X1 T1F5X1 20204220 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG174825|UniProtKB=T1G4I0 T1G4I0 20215978 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG189260|UniProtKB=T1FQV8 T1FQV8 20211205 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154 postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG104040|UniProtKB=T1EDJ3 T1EDJ3 20194645 PTHR10974:SF78 FI08016P-RELATED FI21235P1 HELRO|EnsemblGenome=HelroG177730|UniProtKB=T1FC53 T1FC53 20206402 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186059|UniProtKB=T1FNL9 T1FNL9 20210416 PTHR47979:SF139 DRAB11-RELATED SMALL MONOMERIC GTPASE heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167 regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;localization#GO:0051179;regulation of localization#GO:0032879;regulation of transport#GO:0051049;transport#GO:0006810;regulation of endocytosis#GO:0030100 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;recycling endosome#GO:0055037;intracellular organelle#GO:0043229;endosome#GO:0005768 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG156503|UniProtKB=T1ELX8 T1ELX8 20197578 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG156575|UniProtKB=T1ELY6 T1ELY6 20197586 PTHR11021:SF1 SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;RNA splicing#GO:0008380;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 cytoplasmic ribonucleoprotein granule#GO:0036464;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;P-body#GO:0000932;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;U4/U6 x U5 tri-snRNP complex#GO:0046540;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;U6 snRNP#GO:0005688 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG158805|UniProtKB=T1ENA2 T1ENA2 20198052 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126349|UniProtKB=T1EH96 T1EH96 20195946 PTHR23235:SF207 KRUEPPEL-LIKE TRANSCRIPTION FACTOR SP1, ISOFORM F transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 C2H2 zinc finger transcription factor#PC00248 Huntington disease#P00029>Sp1#P00803 HELRO|EnsemblGenome=HelroG86957|UniProtKB=T1G6J9 T1G6J9 20216696 PTHR24340:SF35 HOMEOBOX PROTEIN NKX HGTX, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG188697|UniProtKB=T1FQ97 T1FQ97 20210994 PTHR10188:SF8 L-ASPARAGINASE THREONINE ASPARTASE 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG166844|UniProtKB=T1EYM1 T1EYM1 20201671 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186499|UniProtKB=T1FP02 T1FP02 20210549 PTHR12900:SF0 MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 CHECKPOINT PROTEIN regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;telomere maintenance#GO:0000723;nucleic acid metabolic process#GO:0090304;mitotic cell cycle checkpoint signaling#GO:0007093;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;recombinational repair#GO:0000725;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stress#GO:0006950;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;metabolic process#GO:0008152;DNA recombination#GO:0006310;negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;double-strand break repair#GO:0006302;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;mitotic DNA replication checkpoint signaling#GO:0033314;signaling#GO:0023052;cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;regulation of G2/M transition of mitotic cell cycle#GO:0010389;telomere organization#GO:0032200;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of mitotic cell cycle phase transition#GO:1901991;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;mitotic intra-S DNA damage checkpoint signaling#GO:0031573 condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;condensed nuclear chromosome#GO:0000794;membrane-enclosed lumen#GO:0031974;site of double-strand break#GO:0035861;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG72321|UniProtKB=T1G0Y2 T1G0Y2 20214730 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Cell cycle#P00013>Protein kinase subunit#P00482;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035 HELRO|EnsemblGenome=HelroG69237|UniProtKB=T1FZR4 T1FZR4 20214312 PTHR12210:SF13 DULLARD PROTEIN PHOSPHATASE CTD SMALL PHOSPHATASE-LIKE PROTEIN 3 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG108234|UniProtKB=T1EEH4 T1EEH4 20194976 PTHR13389:SF0 PUMILIO HOMOLOG 3 PUMILIO HOMOLOG 3 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG126208|UniProtKB=T1EH86 T1EH86 20195936 PTHR45942:SF1 Calcineurin subunit B PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B, ALPHA enzyme regulator activity#GO:0030234;protein binding#GO:0005515;protein phosphatase regulator activity#GO:0019888;phosphatase binding#GO:0019902;binding#GO:0005488;enzyme binding#GO:0019899;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;calcineurin-mediated signaling#GO:0097720;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG173620|UniProtKB=T1F722 T1F722 20204621 PTHR46582:SF1 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 HELRO|EnsemblGenome=HelroG63054|UniProtKB=T1FXA4 T1FXA4 20213452 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG68065|UniProtKB=T1FZ98 T1FZ98 20214146 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG123067|UniProtKB=T1EGW8 T1EGW8 20195818 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG112207|UniProtKB=T1EFH7 T1EFH7 20195329 PTHR13906:SF16 PORCUPINE MEMBRANE-BOUND ACYLGLYCEROPHOSPHATIDYLINOSITOL O-ACYLTRANSFERASE MBOAT7 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 organophosphate biosynthetic process#GO:0090407;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;lipid modification#GO:0030258;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987 mitochondria-associated endoplasmic reticulum membrane contact site#GO:0044233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle membrane contact site#GO:0044232;membrane#GO:0016020 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG189631|UniProtKB=T1FR78 T1FR78 20211325 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG116782|UniProtKB=T1EGH6 T1EGH6 20195678 PTHR18929:SF132 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG87358|UniProtKB=T1G6P3 T1G6P3 20216740 PTHR10202:SF27 PRESENILIN PRESENILIN HOMOLOG catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;signaling#GO:0023052;homeostatic process#GO:0042592;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;inorganic ion homeostasis#GO:0098771;proteolysis#GO:0006508;calcium ion homeostasis#GO:0055074;cell communication#GO:0007154;protein metabolic process#GO:0019538;signal transduction#GO:0007165;membrane protein proteolysis#GO:0033619;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;biosynthetic process#GO:0009058;membrane protein ectodomain proteolysis#GO:0006509;gene expression#GO:0010467;protein maturation#GO:0051604;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219 catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protease#PC00190;aspartic protease#PC00053 Alzheimer disease-amyloid secretase pathway#P00003>Presenilin N-terminal fragment#P00088;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin C-terminal fragment#P00102;Alzheimer disease-presenilin pathway#P00004>Presenilin N-terminal fragment#P00140;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin#P00098;Alzheimer disease-presenilin pathway#P00004>Presenilin#P00129;Alzheimer disease-presenilin pathway#P00004>Presenilin C-terminal fragment#P00155;Notch signaling pathway#P00045>Presenilin#P01110 HELRO|EnsemblGenome=HelroG75990|UniProtKB=T1G2D6 T1G2D6 20215234 PTHR46021:SF2 ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN CENTAURIN ALPHA enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;phosphatidylinositol phosphate binding#GO:1901981;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047 organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG193838|UniProtKB=T1FVE7 T1FVE7 20212793 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190344|UniProtKB=T1FRX3 T1FRX3 20211570 PTHR46606:SF5 SHOOTIN-1 FI03658P neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of cellular process#GO:0050794;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;regulation of neuron migration#GO:2001222;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522 cell projection#GO:0042995;distal axon#GO:0150034;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell leading edge#GO:0031252;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;axon#GO:0030424;axonal growth cone#GO:0044295;growth cone#GO:0030426 HELRO|EnsemblGenome=HelroG183629|UniProtKB=T1FJY7 T1FJY7 20209136 PTHR47293:SF15 JACALIN-RELATED LECTIN 3 JACALIN-RELATED LECTIN 3 HELRO|EnsemblGenome=HelroG184565|UniProtKB=T1FLH6 T1FLH6 20209675 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112394|UniProtKB=T1EFJ5 T1EFJ5 20195347 PTHR11960:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676;translation initiation factor activity#GO:0003743;RNA binding#GO:0003723 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG188804|UniProtKB=T1FQD7 T1FQD7 20211034 PTHR22536:SF1 LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG85938|UniProtKB=T1G647 T1G647 20216544 PTHR11800:SF2 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG174390|UniProtKB=T1F828 T1F828 20204977 PTHR34718:SF3 PHD-TYPE DOMAIN-CONTAINING PROTEIN UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177680|UniProtKB=T1FC26 T1FC26 20206375 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183289|UniProtKB=T1FJF1 T1FJF1 20208950 PTHR21522:SF68 PROTON CHANNEL OTOP SUBFAMILY NOT NAMED channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;proton channel activity#GO:0015252 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG193938|UniProtKB=T1FVH8 T1FVH8 20212824 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase#PC00137;metabolite interconversion enzyme#PC00262 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG175232|UniProtKB=T1F918 T1F918 20205317 PTHR15004:SF0 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL translation#GO:0006412;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG188573|UniProtKB=T1FQ51 T1FQ51 20210948 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG80813|UniProtKB=T1G459 T1G459 20215857 PTHR23257:SF994 SERINE-THREONINE PROTEIN KINASE IP11267P kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG163491|UniProtKB=T1EU46 T1EU46 20200096 PTHR11533:SF294 PROTEASE M1 ZINC METALLOPROTEASE THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME metallopeptidase activity#GO:0008237;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;metabolic process#GO:0008152;proteolysis#GO:0006508;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG169239|UniProtKB=T1F1M2 T1F1M2 20202722 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65527|UniProtKB=T1FY90 T1FY90 20213788 PTHR43920:SF11 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL CLIC monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 intracellular anatomical structure#GO:0005622;apical part of cell#GO:0045177;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG110162|UniProtKB=T1EF01 T1EF01 20195153 PTHR10052:SF1 60S RIBOSOMAL PROTEIN L18A LARGE RIBOSOMAL SUBUNIT PROTEIN EL20 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG136424|UniProtKB=T1EIE0 T1EIE0 20196340 PTHR23235:SF207 KRUEPPEL-LIKE TRANSCRIPTION FACTOR SP1, ISOFORM F sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 C2H2 zinc finger transcription factor#PC00248 Huntington disease#P00029>Sp1#P00803 HELRO|EnsemblGenome=HelroG168181|UniProtKB=T1F097 T1F097 20202247 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167351|UniProtKB=T1EZA6 T1EZA6 20201906 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN FUCOLECTIN-6-LIKE HELRO|EnsemblGenome=HelroG102358|UniProtKB=T1ED96 T1ED96 20194548 PTHR19865:SF0 U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2 U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515;RNA binding#GO:0003723;U3 snoRNA binding#GO:0034511 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HELRO|EnsemblGenome=HelroG184809|UniProtKB=T1FM14 T1FM14 20209863 PTHR46076:SF3 E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RING1 acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;chromatin binding#GO:0003682;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;PcG protein complex#GO:0031519;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107285|UniProtKB=T1EE93 T1EE93 20194895 PTHR47238:SF4 MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG173115|UniProtKB=T1F6D9 T1F6D9 20204388 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164588|UniProtKB=T1EVL8 T1EVL8 20200618 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG181791|UniProtKB=T1FHC1 T1FHC1 20208220 PTHR23233:SF84 SAL-LIKE PROTEIN FI23031P1-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG77768|UniProtKB=T1G337 T1G337 20215485 PTHR20900:SF0 NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG166204|UniProtKB=T1EXW6 T1EXW6 20201416 PTHR16231:SF0 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 8 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 response to peptide#GO:1901652;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;response to tumor necrosis factor#GO:0034612 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG193766|UniProtKB=T1FVC2 T1FVC2 20212768 PTHR13271:SF34 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE N-LYSINE METHYLTRANSFERASE SETD6 protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;lysine N-methyltransferase activity#GO:0016278 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG188163|UniProtKB=T1FPQ2 T1FPQ2 20210799 PTHR13738:SF43 TROPONIN I TROPONIN I protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 muscle contraction#GO:0006936;muscle system process#GO:0003012;system process#GO:0003008;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;sarcomere#GO:0030017;membraneless organelle#GO:0043228;contractile muscle fiber#GO:0043292;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG132254|UniProtKB=T1EHX5 T1EHX5 20196175 PTHR13572:SF4 ENDO-ALPHA-1,2-MANNOSIDASE RE57134P hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 HELRO|EnsemblGenome=HelroG68509|UniProtKB=T1FZG1 T1FZG1 20214209 PTHR43895:SF164 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 HELRO|EnsemblGenome=HelroG79198|UniProtKB=T1G8J4 T1G8J4 20217395 PTHR45810:SF15 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191620|UniProtKB=T1FT49 T1FT49 20211996 PTHR45984:SF1 RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR binding#GO:0005488;heat shock protein binding#GO:0031072;protein binding#GO:0005515 localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585 cytosol#GO:0005829;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179125|UniProtKB=T1FE73 T1FE73 20207122 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188755|UniProtKB=T1FQB9 T1FQB9 20211016 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4 INTERACTING CHROMATIN REMODELING COMPLEX ASSOCIATED PROTEIN, ISOFORM B regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603 HELRO|EnsemblGenome=HelroG183330|UniProtKB=T1FJG9 T1FJG9 20208968 PTHR10223:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488;protein binding#GO:0005515 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 nucleus#GO:0005634;proteasome complex#GO:0000502;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;protease#PC00190 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG194305|UniProtKB=T1FVW8 T1FVW8 20212964 PTHR22883:SF511 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 developmental maturation#GO:0021700;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;protein targeting to membrane#GO:0006612;developmental process#GO:0032502;protein targeting#GO:0006605;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64675|UniProtKB=T1FXX9 T1FXX9 20213677 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;zinc ion binding#GO:0008270;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194207|UniProtKB=T1FVT1 T1FVT1 20212927 PTHR19282:SF519 TETRASPANIN TETRASPANIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172522|UniProtKB=T1F5G4 T1F5G4 20204063 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG91243|UniProtKB=T1G816 T1G816 20217213 PTHR10322:SF23 DNA POLYMERASE CATALYTIC SUBUNIT DNA POLYMERASE DELTA CATALYTIC SUBUNIT exonuclease activity#GO:0004527;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;transferase activity#GO:0016740;DNA exonuclease activity#GO:0004529;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;hydrolase activity#GO:0016787;DNA-directed DNA polymerase activity#GO:0003887;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;base-excision repair#GO:0006284;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;replisome#GO:0030894;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694 DNA metabolism protein#PC00009 DNA replication#P00017>Pol delta#P00533 HELRO|EnsemblGenome=HelroG188097|UniProtKB=T1FPM6 T1FPM6 20210773 PTHR13723:SF327 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PLAC DOMAIN-CONTAINING PROTEIN metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG155168|UniProtKB=T1ELH4 T1ELH4 20197424 PTHR24276:SF99 POLYSERASE-RELATED AT26814P-RELATED serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG113902|UniProtKB=T1EFX3 T1EFX3 20195475 PTHR10937:SF0 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING) catalytic activity#GO:0003824;transferase activity#GO:0016740;transaminase activity#GO:0008483 nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;amino sugar metabolic process#GO:0006040;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;UDP-N-acetylglucosamine metabolic process#GO:0006047;organophosphate biosynthetic process#GO:0090407;UDP-N-acetylglucosamine biosynthetic process#GO:0006048 transaminase#PC00216 O-antigen biosynthesis#P02757>Fructose-6-phosphate aminotransferase#P03051;N-acetylglucosamine metabolism#P02756>Fructose-6-phosphate aminotransferase#P03042 HELRO|EnsemblGenome=HelroG190959|UniProtKB=T1FSG6 T1FSG6 20211763 PTHR12480:SF19 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD CUPIN-LIKE DOMAIN-CONTAINING PROTEIN oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;sequence-specific DNA binding#GO:0043565;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of translation#GO:0045727;positive regulation of protein metabolic process#GO:0051247;positive regulation of cellular component organization#GO:0051130;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of protein-containing complex disassembly#GO:0043244;regulation of translation#GO:0006417;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG92549|UniProtKB=T1G8I4 T1G8I4 20217381 PTHR24248:SF209 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 5A ISOFORM X1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167193|UniProtKB=T1EZ45 T1EZ45 20201845 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191631|UniProtKB=T1FT55 T1FT55 20212002 PTHR19324:SF33 PERFORIN-LIKE PROTEIN 1 MUCIN-5AC HELRO|EnsemblGenome=HelroG71342|UniProtKB=T1G0J9 T1G0J9 20214597 PTHR22809:SF5 METHYLTRANSFERASE-RELATED TRNA N(3)-CYTIDINE METHYLTRANSFERASE METTL6 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185751|UniProtKB=T1FN88 T1FN88 20210286 PTHR43866:SF3 MALONATE-SEMIALDEHYDE DEHYDROGENASE METHYLMALONATE-SEMIALDEHYDE_MALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity#GO:0016491 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;nucleobase catabolic process#GO:0046113;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carboxylic acid catabolic process#GO:0046395;pyrimidine nucleobase metabolic process#GO:0006206;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>Methylmalonate Semialdehyde Dehydrogenase#P03124 HELRO|EnsemblGenome=HelroG122641|UniProtKB=T1EGV4 T1EGV4 20195804 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG62030|UniProtKB=T1FWU3 T1FWU3 20213291 PTHR16469:SF27 UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BB-RELATED HELRO|EnsemblGenome=HelroG108452|UniProtKB=T1EEJ0 T1EEJ0 20194992 PTHR42861:SF29 CALCIUM-TRANSPORTING ATPASE P-TYPE CA(2+) TRANSPORTER P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829 homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810 endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG100974|UniProtKB=T1ED25 T1ED25 20194477 PTHR14360:SF1 PROTEIN FMP32, MITOCHONDRIAL PROTEIN FMP32, MITOCHONDRIAL membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG188529|UniProtKB=T1FQ34 T1FQ34 20210931 PTHR23065:SF15 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 AT02057P transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;receptor-mediated endocytosis#GO:0006898;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;protein-containing complex assembly#GO:0065003;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular component assembly#GO:0022607 endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;clathrin-coated vesicle#GO:0030136;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG186006|UniProtKB=T1FNJ5 T1FNJ5 20210392 PTHR43464:SF105 METHYLTRANSFERASE UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;ketone metabolic process#GO:0042180;ubiquinone biosynthetic process#GO:0006744;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG107037|UniProtKB=T1EE67 T1EE67 20194869 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG89289|UniProtKB=T1G7B4 T1G7B4 20216961 PTHR23032:SF13 BRO1 DOMAIN-CONTAINING PROTEIN BROX BRO1 DOMAIN-CONTAINING PROTEIN BROX HELRO|EnsemblGenome=HelroG165728|UniProtKB=T1EX78 T1EX78 20201178 PTHR34717:SF1 EG:BACR7A4.20 PROTEIN EG:BACR7A4.20 PROTEIN HELRO|EnsemblGenome=HelroG191108|UniProtKB=T1FSL5 T1FSL5 20211812 PTHR24291:SF201 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG112333|UniProtKB=T1EFI8 T1EFI8 20195340 PTHR11098:SF1 NICOTINATE PHOSPHORIBOSYLTRANSFERASE NICOTINATE PHOSPHORIBOSYLTRANSFERASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG102150|UniProtKB=T1ED85 T1ED85 20194537 PTHR23408:SF3 METHYLMALONYL-COA MUTASE METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 mutase#PC00160 HELRO|EnsemblGenome=HelroG82544|UniProtKB=T1G4T5 T1G4T5 20216083 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HELRO|EnsemblGenome=HelroG95192|UniProtKB=T1G949 T1G949 20217596 PTHR16515:SF88 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG168788|UniProtKB=T1F0Z1 T1F0Z1 20202491 PTHR15440:SF0 XRP2 PROTEIN PROTEIN XRP2 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;post-Golgi vesicle-mediated transport#GO:0006892;cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cilium#GO:0005929;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG112342|UniProtKB=T1EFI9 T1EFI9 20195341 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;myosin binding#GO:0017022;SNARE binding#GO:0000149;enzyme activator activity#GO:0008047;cytoskeletal protein binding#GO:0008092;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;syntaxin binding#GO:0019905;binding#GO:0005488 transport#GO:0006810;regulation of response to stimulus#GO:0048583;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;establishment of spindle localization#GO:0051293;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of Notch signaling pathway#GO:0008593;actin filament-based process#GO:0030029;localization within membrane#GO:0051668;organelle localization#GO:0051640;cortical cytoskeleton organization#GO:0030865;secretion#GO:0046903;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;cortical actin cytoskeleton organization#GO:0030866;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;Golgi to plasma membrane transport#GO:0006893;Golgi vesicle transport#GO:0048193;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;exocytosis#GO:0006887;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878;vesicle-mediated transport#GO:0016192;regulation of signaling#GO:0023051;establishment or maintenance of cell polarity#GO:0007163;post-Golgi vesicle-mediated transport#GO:0006892;secretion by cell#GO:0032940;spindle localization#GO:0051653;cellular localization#GO:0051641;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;export from cell#GO:0140352;establishment of organelle localization#GO:0051656 actin cytoskeleton#GO:0015629;membrane#GO:0016020;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG71825|UniProtKB=T1G0S0 T1G0S0 20214668 PTHR10416:SF0 DNA POLYMERASE DELTA SUBUNIT 2 DNA POLYMERASE DELTA SUBUNIT 2 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;translesion synthesis#GO:0019985;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA synthesis involved in DNA replication#GO:0090592;DNA-templated DNA replication#GO:0006261 intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;replisome#GO:0030894;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear replication fork#GO:0043596;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575 DNA metabolism protein#PC00009;DNA-directed DNA polymerase#PC00018 DNA replication#P00017>Pol delta#P00533 HELRO|EnsemblGenome=HelroG168555|UniProtKB=T1F0Q2 T1F0Q2 20202402 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG161551|UniProtKB=T1ERM0 T1ERM0 20199220 PTHR15712:SF23 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT CONTAINING 10 organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76370|UniProtKB=T1G2J1 T1G2J1 20215289 PTHR31214:SF3 PROTEIN FAM221A-RELATED PROTEIN FAM221B HELRO|EnsemblGenome=HelroG191022|UniProtKB=T1FSI4 T1FSI4 20211781 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG76186|UniProtKB=T1G2G4 T1G2G4 20215262 PTHR22914:SF42 CHITIN SYNTHASE CHITIN SYNTHASE acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;aminoglycan biosynthetic process#GO:0006023;biosynthetic process#GO:0009058;amino sugar metabolic process#GO:0006040;chitin metabolic process#GO:0006030;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transferase#PC00220 HELRO|EnsemblGenome=HelroG68663|UniProtKB=T1FZH8 T1FZH8 20214226 PTHR43788:SF16 DNA2/NAM7 HELICASE FAMILY MEMBER 3'-5' EXORIBONUCLEASE HELZ2 ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853 response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stress#GO:0006950 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG166961|UniProtKB=T1EYT3 T1EYT3 20201733 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193832|UniProtKB=T1FVE5 T1FVE5 20212791 PTHR19860:SF42 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED DUF4062 DOMAIN-CONTAINING PROTEIN Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HELRO|EnsemblGenome=HelroG72135|UniProtKB=T1G0W4 T1G0W4 20214712 PTHR24399:SF83 ZINC FINGER AND BTB DOMAIN-CONTAINING GROWTH FACTOR INDEPENDENT 1A TRANSCRIPTION REPRESSOR A ISOFORM X1 transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG164180|UniProtKB=T1EV19 T1EV19 20200419 PTHR31705:SF4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG71907|UniProtKB=T1G0S9 T1G0S9 20214677 PTHR13073:SF0 BLOC-1 COMPLEX SUBUNIT 1 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907 protein-containing complex#GO:0032991;BLOC-1 complex#GO:0031083;intracellular protein-containing complex#GO:0140535 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191748|UniProtKB=T1FT95 T1FT95 20212042 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 system process#GO:0003008;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;muscle contraction#GO:0006936;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;muscle system process#GO:0003012;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG179731|UniProtKB=T1FF31 T1FF31 20207430 PTHR11683:SF12 MYELIN PROTEOLIPID M6, ISOFORM F animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;cellular component organization#GO:0016043;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 myelin protein#PC00161 HELRO|EnsemblGenome=HelroG193731|UniProtKB=T1FVA9 T1FVA9 20212755 PTHR13471:SF0 TETRATRICOPEPTIDE-LIKE HELICAL NUCLEAR EXOSOME REGULATOR NRDE2 regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulatory ncRNA-mediated heterochromatin formation#GO:0031048;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607 HELRO|EnsemblGenome=HelroG67798|UniProtKB=T1FZ55 T1FZ55 20214103 PTHR43816:SF1 NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757 purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;pyridine-containing compound metabolic process#GO:0072524;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG190605|UniProtKB=T1FS45 T1FS45 20211642 PTHR12062:SF9 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101 Golgi stack#GO:0005795;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 transferase#PC00220 HELRO|EnsemblGenome=HelroG116728|UniProtKB=T1EGH3 T1EGH3 20195675 PTHR10778:SF4 SOLUTE CARRIER FAMILY 35 MEMBER B NUCLEOTIDE SUGAR TRANSPORTER SLC35B4 carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 nucleotide-sugar transmembrane transport#GO:0015780;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG67653|UniProtKB=T1FZ35 T1FZ35 20214083 PTHR23304:SF183 SPOT2-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189355|UniProtKB=T1FQZ9 T1FQZ9 20211246 PTHR10501:SF49 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B PROTEIN COUCH POTATO RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG133665|UniProtKB=T1EI22 T1EI22 20196222 PTHR15750:SF2 VASOHIBIN-1-LIKE ISOFORM X2 VASOHIBIN HELRO|EnsemblGenome=HelroG174683|UniProtKB=T1F8D3 T1F8D3 20205082 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG179051|UniProtKB=T1FE39 T1FE39 20207088 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189810|UniProtKB=T1FRD9 T1FRD9 20211386 PTHR13976:SF76 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED AT27789P ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169679|UniProtKB=T1F279 T1F279 20202929 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175348|UniProtKB=T1F964 T1F964 20205363 PTHR45888:SF5 HL01030P-RELATED D4, ISOFORM A transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG74868|UniProtKB=T1G1W7 T1G1W7 20215065 PTHR22604:SF105 OXIDOREDUCTASES TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carbohydrate metabolic process#GO:0005975;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate catabolic process#GO:0016052 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185065|UniProtKB=T1FMC7 T1FMC7 20209976 PTHR21139:SF2 TRIOSEPHOSPHATE ISOMERASE TRIOSEPHOSPHATE ISOMERASE intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861 monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;ATP metabolic process#GO:0046034;aldehyde metabolic process#GO:0006081;gluconeogenesis#GO:0006094;nicotinamide nucleotide metabolic process#GO:0046496;oxoacid metabolic process#GO:0043436;glyceraldehyde-3-phosphate metabolic process#GO:0019682;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;ribonucleoside diphosphate metabolic process#GO:0009185;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;nucleotide catabolic process#GO:0009166;small molecule biosynthetic process#GO:0044283;energy derivation by oxidation of organic compounds#GO:0015980;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide catabolic process#GO:0006195;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;nucleoside diphosphate catabolic process#GO:0009134;hexose biosynthetic process#GO:0019319;purine ribonucleotide catabolic process#GO:0009154;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;ADP catabolic process#GO:0046032;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;monocarboxylic acid metabolic process#GO:0032787;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;pyruvate metabolic process#GO:0006090;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;ADP metabolic process#GO:0046031;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate catabolic process#GO:1901292;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Glycolysis#P00024>Triosephosphate isomerase#P00673 HELRO|EnsemblGenome=HelroG113689|UniProtKB=T1EFV0 T1EFV0 20195452 PTHR11587:SF11 ARGININOSUCCINATE SYNTHASE ARGININOSUCCINATE SYNTHASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879 proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;arginine metabolic process#GO:0006525;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;proteinogenic amino acid biosynthetic process#GO:0170038;L-arginine biosynthetic process#GO:0006526;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;ligase#PC00142 Arginine biosynthesis#P02728>Argininosuccinate synthase#P02840 HELRO|EnsemblGenome=HelroG175466|UniProtKB=T1F9A4 T1F9A4 20205403 PTHR12618:SF20 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG143362|UniProtKB=T1EJA3 T1EJA3 20196653 PTHR12357:SF140 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN protein-RNA adaptor activity#GO:0140517;protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;molecular adaptor activity#GO:0060090;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;positive regulation of mRNA catabolic process#GO:0061014;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG156718|UniProtKB=T1EM02 T1EM02 20197602 PTHR31078:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 structural protein#PC00211 HELRO|EnsemblGenome=HelroG70073|UniProtKB=T1G023 T1G023 20214421 PTHR11937:SF16 ACTIN ACTIN-RELATED PROTEIN 5 structural constituent of cytoskeleton#GO:0005200;enzyme regulator activity#GO:0030234;structural molecule activity#GO:0005198;molecular function regulator activity#GO:0098772 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;Ino80 complex#GO:0031011;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 actin and actin related protein#PC00039 HELRO|EnsemblGenome=HelroG159593|UniProtKB=T1EP78 T1EP78 20198378 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 HELRO|EnsemblGenome=HelroG158421|UniProtKB=T1EMR8 T1EMR8 20197868 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168921|UniProtKB=T1F148 T1F148 20202548 PTHR21522:SF32 PROTON CHANNEL OTOP PROTON CHANNEL OTOPLC proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;proton channel activity#GO:0015252;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG155129|UniProtKB=T1FME7 T1FME7 20197421 PTHR11937:SF607 ACTIN ACTIN-42A-RELATED structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;cell division#GO:0051301;cytoskeleton-dependent cytokinesis#GO:0061640;cortical actin cytoskeleton organization#GO:0030866;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG158598|UniProtKB=T1EN01 T1EN01 20197951 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194499|UniProtKB=T1FW46 T1FW46 20213042 PTHR15898:SF13 BIFUNCTIONAL APOPTOSIS REGULATOR GLUCOSE-INDUCED DEGRADATION PROTEIN 4 HOMOLOG ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 HELRO|EnsemblGenome=HelroG179343|UniProtKB=T1FEK8 T1FEK8 20207257 PTHR23316:SF87 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;cellular localization#GO:0051641;protein localization to organelle#GO:0033365;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227 HELRO|EnsemblGenome=HelroG81107|UniProtKB=T1G494 T1G494 20215892 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK-1 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162934|UniProtKB=T1ETD7 T1ETD7 20199837 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG161614|UniProtKB=T1ERQ0 T1ERQ0 20199250 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194877|UniProtKB=T1FWI6 T1FWI6 20213181 PTHR45679:SF10 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 response to unfolded protein#GO:0006986;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;protein catabolic process#GO:0030163;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;protein metabolic process#GO:0019538;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;biological regulation#GO:0065007;carbohydrate derivative metabolic process#GO:1901135;endoplasmic reticulum unfolded protein response#GO:0030968 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG72857|UniProtKB=T1G162 T1G162 20214810 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG189228|UniProtKB=T1FQU0 T1FQU0 20211187 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG189237|UniProtKB=T1FQU6 T1FQU6 20211193 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG187654|UniProtKB=T1FPB5 T1FPB5 20210662 PTHR10724:SF10 30S RIBOSOMAL PROTEIN S1 S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1 RNA binding#GO:0003723;structural molecule activity#GO:0005198;mRNA binding#GO:0003729;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG70084|UniProtKB=T1G025 T1G025 20214423 PTHR10110:SF126 SODIUM/HYDROGEN EXCHANGER NA(+)_H(+) EXCHANGER PROTEIN 7 monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078 regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG67417|UniProtKB=T1FZ05 T1FZ05 20214053 PTHR24083:SF104 NUCLEAR HORMONE RECEPTOR TRANSCRIPTION FACTOR HNF-4 HOMOLOG transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG91651|UniProtKB=T1G872 T1G872 20217269 PTHR19321:SF57 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle elongation#GO:0051231;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;nuclear division#GO:0000280;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014 intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG166269|UniProtKB=T1EXY7 T1EXY7 20201437 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG157588|UniProtKB=T1EMD6 T1EMD6 20197736 PTHR24351:SF110 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;TORC1 signaling#GO:0038202 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;Interleukin signaling pathway#P00036>p90RSK#P00964;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG189234|UniProtKB=T1FQU4 T1FQU4 20211191 PTHR11533:SF294 PROTEASE M1 ZINC METALLOPROTEASE THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235 primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG91458|UniProtKB=T1G840 T1G840 20217237 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN LD44267P cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG159872|UniProtKB=T1EPH3 T1EPH3 20198473 PTHR12542:SF41 EXOCYST COMPLEX PROTEIN EXO70 EXOCYST COMPLEX COMPONENT 7 vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;exocyst#GO:0000145;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG136356|UniProtKB=T1EID6 T1EID6 20196336 PTHR23235:SF196 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG164477|UniProtKB=T1EVH2 T1EVH2 20200572 PTHR36162:SF20 FAMILY NOT NAMED GLUTAMINE-RICH PROTEIN 2 HELRO|EnsemblGenome=HelroG158082|UniProtKB=T1EMJ2 T1EMJ2 20197792 PTHR10889:SF3 DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOXYRIBOSE-PHOSPHATE ALDOLASE carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;aldehyde-lyase activity#GO:0016832;lyase activity#GO:0016829 nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside catabolic process#GO:0009164;metabolic process#GO:0008152;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 lyase#PC00144;aldolase#PC00044 HELRO|EnsemblGenome=HelroG156207|UniProtKB=T1ELS7 T1ELS7 20197527 PTHR24068:SF144 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 C-RELATED ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096 post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic cell cycle#GO:0007346;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of chromosome organization#GO:0033044;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cell cycle phase transition#GO:1901987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;regulation of cell cycle process#GO:0010564;cellular process#GO:0009987;regulation of chromosome segregation#GO:0051983;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of mitotic cell cycle phase transition#GO:1901990;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG68329|UniProtKB=T1FZD1 T1FZD1 20214179 PTHR11753:SF5 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;transport#GO:0006810 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG159526|UniProtKB=T1EP47 T1EP47 20198347 PTHR11616:SF340 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;glycine transmembrane transporter activity#GO:0015187;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;sodium ion transport#GO:0006814;localization#GO:0051179;monoatomic cation transport#GO:0006812;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;monoatomic ion transport#GO:0006811;glycine transport#GO:0015816;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;nitrogen compound transport#GO:0071705;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG185445|UniProtKB=T1FMU2 T1FMU2 20210141 PTHR11227:SF29 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 4 lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;process utilizing autophagic mechanism#GO:0061919;carbohydrate catabolic process#GO:0016052;polysaccharide catabolic process#GO:0000272;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;glucan catabolic process#GO:0009251;polysaccharide metabolic process#GO:0005976;generation of precursor metabolites and energy#GO:0006091;autophagy of mitochondrion#GO:0000422;intracellular protein localization#GO:0008104;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;glycogen catabolic process#GO:0005980;macromolecule localization#GO:0033036;macroautophagy#GO:0016236;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;vacuole organization#GO:0007033;localization#GO:0051179;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056 membrane#GO:0016020;phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166256|UniProtKB=T1EXY4 T1EXY4 20201434 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG171280|UniProtKB=T1F411 T1F411 20203560 PTHR15073:SF16 MICROTUBULE-ASSOCIATED PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG93910|UniProtKB=T1G8Y1 T1G8Y1 20217528 PTHR12385:SF14 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG174018|UniProtKB=T1F7H5 T1F7H5 20204774 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG119046|UniProtKB=T1EGM3 T1EGM3 20195723 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1A-RELATED potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG177728|UniProtKB=T1FC52 T1FC52 20206401 PTHR11559:SF370 CARBOXYLESTERASE CARBOXYLIC ESTER HYDROLASE-RELATED esterase#PC00097 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067 HELRO|EnsemblGenome=HelroG63669|UniProtKB=T1FXI8 T1FXI8 20213536 PTHR10763:SF26 CELL DIVISION CONTROL PROTEIN 6-RELATED DNA REPLICATION FACTOR CDC6 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690 cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG163970|UniProtKB=T1EUP5 T1EUP5 20200295 PTHR15690:SF0 NUCLEAR RECEPTOR COACTIVATOR 6 NUCLEAR RECEPTOR COACTIVATOR 6 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164018|UniProtKB=T1EUS0 T1EUS0 20200320 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG142541|UniProtKB=T1EJ61 T1EJ61 20196611 PTHR48051:SF1 FAMILY NOT NAMED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155848|UniProtKB=T1ELN3 T1ELN3 20197483 PTHR12315:SF1 BICOID-INTERACTING PROTEIN RELATED RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of cellular process#GO:0048523;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of cellular process#GO:0050794;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG161220|UniProtKB=T1ER82 T1ER82 20199082 PTHR21580:SF28 SHIPPO-1-RELATED SPERM-TAIL PG-RICH REPEAT FAMILY PROTEIN cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG185661|UniProtKB=T1FN38 T1FN38 20210236 PTHR24055:SF599 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE ERK-A protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>MAPK#P00269;FGF signaling pathway#P00021>ERK1-2#P00627;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Endothelin signaling pathway#P00019>ERK#P00566;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;Parkinson disease#P00049>ERK#P01211;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293 HELRO|EnsemblGenome=HelroG97639|UniProtKB=T1G9I2 T1G9I2 20217729 PTHR11915:SF455 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ, SARCOMERIC-RELATED protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 cell development#GO:0048468;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cell differentiation#GO:0030154;muscle cell differentiation#GO:0042692;cellular component organization#GO:0016043;muscle cell development#GO:0055001;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 I band#GO:0031674;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054;Z disc#GO:0030018;cell periphery#GO:0071944;contractile muscle fiber#GO:0043292;membrane#GO:0016020;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HELRO|EnsemblGenome=HelroG171204|UniProtKB=T1F3X7 T1F3X7 20203526 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;molecular transducer activity#GO:0060089;hormone binding#GO:0042562;binding#GO:0005488 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194436|UniProtKB=T1FW19 T1FW19 20213015 PTHR46848:SF1 REGULATOR OF G-PROTEIN SIGNALING 3 REGULATOR OF G PROTEIN SIGNALING 3 intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG186233|UniProtKB=T1FNU7 T1FNU7 20210494 PTHR10104:SF1 STATHMIN STATHMIN, ISOFORM D protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488 developmental process#GO:0032502;neurogenesis#GO:0022008;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular developmental process#GO:0048869;microtubule polymerization or depolymerization#GO:0031109;protein depolymerization#GO:0051261;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;neuron differentiation#GO:0030182;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;regulation of microtubule cytoskeleton organization#GO:0070507;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;cellular component disassembly#GO:0022411;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154 cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG75625|UniProtKB=T1G277 T1G277 20215175 PTHR22891:SF111 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-3 RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membrane-bounded organelle#GO:0043227 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG63746|UniProtKB=T1FXJ6 T1FXJ6 20213544 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79679|UniProtKB=T1G3S2 T1G3S2 20215720 PTHR43520:SF35 ATP7, ISOFORM B P-TYPE CU(+) TRANSPORTER monoatomic cation transmembrane transporter activity#GO:0008324;metal ion binding#GO:0046872;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;binding#GO:0005488;transition metal ion transmembrane transporter activity#GO:0046915;metal ion transmembrane transporter activity#GO:0046873;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;copper ion binding#GO:0005507;cation binding#GO:0043169;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;ion binding#GO:0043167;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857 intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;copper ion transmembrane transport#GO:0035434;homeostatic process#GO:0042592;metal ion transport#GO:0030001 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG84379|UniProtKB=T1G5I1 T1G5I1 20216328 PTHR23423:SF17 ORGANIC SOLUTE TRANSPORTER-RELATED IP17403P transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG155987|UniProtKB=T1ELQ5 T1ELQ5 20197505 PTHR24343:SF576 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 negative regulation of signal transduction#GO:0009968;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;negative regulation of TORC1 signaling#GO:1904262;response to stimulus#GO:0050896;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;macromolecule localization#GO:0033036;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular response to glucose starvation#GO:0042149;positive regulation of catabolic process#GO:0009896;intracellular protein localization#GO:0008104;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;negative regulation of TOR signaling#GO:0032007;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;localization#GO:0051179 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191446|UniProtKB=T1FSZ9 T1FSZ9 20211946 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of catabolic process#GO:0009895;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;mRNA stabilization#GO:0048255;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;multicellular organism development#GO:0007275 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG158525|UniProtKB=T1EMW8 T1EMW8 20197918 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194878|UniProtKB=T1FWI7 T1FWI7 20213182 PTHR23275:SF100 CABRIOLET.-RELATED SURFACE ANTIGEN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG172059|UniProtKB=T1F4Z5 T1F4Z5 20203894 PTHR23244:SF467 KELCH REPEAT DOMAIN EF-HAND DOMAIN-CONTAINING PROTEIN signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 HELRO|EnsemblGenome=HelroG181803|UniProtKB=T1FHC4 T1FHC4 20208223 PTHR13361:SF1 WW DOMAIN-BINDING PROTEIN 11 WW DOMAIN-BINDING PROTEIN 11 enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070 HELRO|EnsemblGenome=HelroG68255|UniProtKB=T1FZC0 T1FZC0 20214168 PTHR45832:SF8 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG184669|UniProtKB=T1FLQ6 T1FLQ6 20209755 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190408|UniProtKB=T1FRY9 T1FRY9 20211586 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 enzyme inhibitor activity#GO:0004857;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;kinase inhibitor activity#GO:0019210;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG90788|UniProtKB=T1G7W4 T1G7W4 20217161 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165500|UniProtKB=T1EWX2 T1EWX2 20201072 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165061|UniProtKB=T1EW83 T1EW83 20200833 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194252|UniProtKB=T1FVV2 T1FVV2 20212948 PTHR24179:SF21 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12B enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG167105|UniProtKB=T1EZ10 T1EZ10 20201810 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN FUCOLECTIN-6-LIKE HELRO|EnsemblGenome=HelroG110232|UniProtKB=T1EF07 T1EF07 20195159 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83454|UniProtKB=T1G557 T1G557 20216205 PTHR13137:SF6 DC11 ACN9 HOMOLOG SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex II assembly#GO:0034553;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG88660|UniProtKB=T1G751 T1G751 20216898 PTHR45936:SF1 TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191237|UniProtKB=T1FSS0 T1FSS0 20211867 PTHR15157:SF5 UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;process utilizing autophagic mechanism#GO:0061919;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid biosynthetic process#GO:0008654;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;autophagy#GO:0006914;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;macroautophagy#GO:0016236;biosynthetic process#GO:0009058 lytic vacuole#GO:0000323;extrinsic component of membrane#GO:0019898;transferase complex#GO:1990234;cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;phosphatidylinositol 3-kinase complex, class III#GO:0035032;endosome#GO:0005768;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708 HELRO|EnsemblGenome=HelroG189289|UniProtKB=T1FQX3 T1FQX3 20211220 PTHR13469:SF8 HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1 HEXIM P-TEFB COMPLEX SUBUNIT 1 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;snRNA binding#GO:0017069;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG160540|UniProtKB=T1EQE1 T1EQE1 20198791 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG162640|UniProtKB=T1ESY7 T1ESY7 20199687 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG120735|UniProtKB=T1EGQ5 T1EGQ5 20195755 PTHR11660:SF57 SOLUTE CARRIER FAMILY 40 MEMBER SOLUTE CARRIER FAMILY 40 MEMBER secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG112732|UniProtKB=T1EFL6 T1EFL6 20195368 PTHR12422:SF1 GH09096P GH09096P HELRO|EnsemblGenome=HelroG172447|UniProtKB=T1F5C4 T1F5C4 20204023 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188774|UniProtKB=T1FQC4 T1FQC4 20211021 PTHR46292:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 102A COILED-COIL DOMAIN-CONTAINING PROTEIN 102A HELRO|EnsemblGenome=HelroG109918|UniProtKB=T1EEX3 T1EEX3 20195125 PTHR10336:SF36 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;lipase activity#GO:0016298;hydrolase activity#GO:0016787 monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;establishment of localization#GO:0051234;transport#GO:0006810;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;metabolic process#GO:0008152;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143 Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Metabotropic glutamate receptor group I pathway#P00041>PLC#P01053;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Endothelin signaling pathway#P00019>PLCbeta#P00591;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PLC#P01068;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Wnt signaling pathway#P00057>Phospholipase C#P01443;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874 HELRO|EnsemblGenome=HelroG159566|UniProtKB=T1EP63 T1EP63 20198363 PTHR11753:SF6 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-2 COMPLEX SUBUNIT SIGMA vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG179553|UniProtKB=T1FEV3 T1FEV3 20207352 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261 import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HELRO|EnsemblGenome=HelroG86856|UniProtKB=T1G6I3 T1G6I3 20216680 PTHR24351:SF249 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182722|UniProtKB=T1FIN2 T1FIN2 20208681 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG174405|UniProtKB=T1F833 T1F833 20204982 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG194550|UniProtKB=T1FW67 T1FW67 20213063 PTHR21330:SF1 E3 SUMO-PROTEIN LIGASE NSE2 E3 SUMO-PROTEIN LIGASE NSE2 ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;recombinational repair#GO:0000725;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA recombination#GO:0006310;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;protein sumoylation#GO:0016925;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;post-translational protein modification#GO:0043687 nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG90358|UniProtKB=T1G7P6 T1G7P6 20217093 PTHR24189:SF78 MYOTROPHIN HOMEOBOX PROTEIN WARIAI HELRO|EnsemblGenome=HelroG194330|UniProtKB=T1FVY0 T1FVY0 20212976 PTHR11679:SF3 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG171194|UniProtKB=T1F3X3 T1F3X3 20203522 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN binding#GO:0005488;hormone binding#GO:0042562;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164735|UniProtKB=T1EVR5 T1EVR5 20200665 PTHR14063:SF1 PROTEIN LIN-7 HOMOLOG PDZ DOMAIN-CONTAINING PROTEIN 11 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;regulation of cellular component organization#GO:0051128;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;regulation of synapse organization#GO:0050807;cellular localization#GO:0051641;secretion by cell#GO:0032940;regulation of biological quality#GO:0065008;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;synaptic vesicle localization#GO:0097479;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of growth#GO:0040008;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;signal release#GO:0023061;organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;regulation of cell junction assembly#GO:1901888;localization#GO:0051179;cell communication#GO:0007154;regulation of synapse structure or activity#GO:0050803;secretion#GO:0046903;vesicle localization#GO:0051648;regulation of synapse assembly#GO:0051963;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;transport#GO:0006810;establishment of localization#GO:0051234 basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;cell-cell junction#GO:0005911;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell junction#GO:0030054;anchoring junction#GO:0070161 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG87213|UniProtKB=T1G6N1 T1G6N1 20216728 PTHR12497:SF8 TAZ PROTEIN TAFAZZIN TAFAZZIN acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 phospholipid metabolic process#GO:0006644;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;cellular component organization#GO:0016043;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;glycerophospholipid metabolic process#GO:0006650;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrial membrane organization#GO:0007006;organophosphate metabolic process#GO:0019637;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG186498|UniProtKB=T1FP01 T1FP01 20210548 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cell fate commitment#GO:0045165;system development#GO:0048731;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HELRO|EnsemblGenome=HelroG178870|UniProtKB=T1FDU5 T1FDU5 20206994 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG188397|UniProtKB=T1FPY1 T1FPY1 20210878 PTHR13800:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG89886|UniProtKB=T1G7I8 T1G7I8 20217035 PTHR11178:SF1 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG67877|UniProtKB=T1FZ68 T1FZ68 20214116 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR ALLATOSTATIN A RECEPTOR 2, ISOFORM A signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG99525|UniProtKB=T1G9T2 T1G9T2 20217828 PTHR12233:SF1 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26 macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;cytosolic transport#GO:0016482;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;retromer complex#GO:0030904;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG73530|UniProtKB=T1G1F3 T1G1F3 20214901 PTHR45628:SF40 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;trans-synaptic signaling#GO:0099537;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;import across plasma membrane#GO:0098739;calcium ion import#GO:0070509;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;calcium ion transmembrane transport#GO:0070588;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular process#GO:0009987;synaptic signaling#GO:0099536 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022 HELRO|EnsemblGenome=HelroG64541|UniProtKB=T1FXW2 T1FXW2 20213660 PTHR23189:SF137 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN SPENITO RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176961|UniProtKB=T1FB25 T1FB25 20206024 PTHR22691:SF8 YEAST SPT2-RELATED PROTEIN SPT2 HOMOLOG DNA binding#GO:0003677;protein binding#GO:0005515;binding#GO:0005488;nucleic acid binding#GO:0003676;histone binding#GO:0042393 cellular component biogenesis#GO:0044085;transcription by RNA polymerase I#GO:0006360;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;chromatin remodeling#GO:0006338;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG172521|UniProtKB=T1F5G3 T1F5G3 20204062 PTHR16021:SF27 MANSC DOMAIN CONTAINING PROTEIN 1 SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG74104|UniProtKB=T1G1M4 T1G1M4 20214972 PTHR12547:SF190 CCCH ZINC FINGER/TIS11-RELATED PROTEIN TIS11 RNA binding#GO:0003723;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;protein-RNA adaptor activity#GO:0140517;molecular adaptor activity#GO:0060090 positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169718|UniProtKB=T1F298 T1F298 20202948 PTHR46165:SF7 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 MYND-TYPE DOMAIN-CONTAINING PROTEIN enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG68342|UniProtKB=T1FZD3 T1FZD3 20214181 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH19970P-RELATED secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG175308|UniProtKB=T1F947 T1F947 20205346 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;cellular localization#GO:0051641;localization#GO:0051179;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;regulation of establishment or maintenance of cell polarity#GO:0032878;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG70423|UniProtKB=T1G065 T1G065 20214463 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG105425|UniProtKB=T1EDU8 T1EDU8 20194750 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 chloride transmembrane transport#GO:1902476;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG85673|UniProtKB=T1G613 T1G613 20216510 PTHR12581:SF0 HIV-1 REV BINDING PROTEIN 2, 3 KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171411|UniProtKB=T1F490 T1F490 20203639 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133 HELRO|EnsemblGenome=HelroG64455|UniProtKB=T1FXV3 T1FXV3 20213651 PTHR48025:SF28 OS02G0815200 PROTEIN RRM DOMAIN-CONTAINING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG177168|UniProtKB=T1FBB1 T1FBB1 20206110 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN developmental process#GO:0032502;anatomical structure development#GO:0048856 HELRO|EnsemblGenome=HelroG99365|UniProtKB=T1G9S3 T1G9S3 20217819 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A8-LIKE monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG85810|UniProtKB=T1G629 T1G629 20216526 PTHR12259:SF1 RGS-GAIP INTERACTING PROTEIN GIPC GH21964P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165840|UniProtKB=T1EXC7 T1EXC7 20201227 PTHR24351:SF228 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188458|UniProtKB=T1FQ04 T1FQ04 20210901 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG62096|UniProtKB=T1FWV7 T1FWV7 20213305 PTHR10155:SF38 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG194632|UniProtKB=T1FW90 T1FW90 20213086 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of metabolic process#GO:0019222;negative regulation of gene expression#GO:0010629;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG119785|UniProtKB=T1EGN6 T1EGN6 20195736 PTHR24351:SF209 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 response to peptide hormone#GO:0043434;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;response to hormone#GO:0009725;response to endogenous stimulus#GO:0009719 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175568|UniProtKB=T1F9D9 T1F9D9 20205438 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG119038|UniProtKB=T1EGM2 T1EGM2 20195722 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;voltage-gated sodium channel activity#GO:0005248;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;transport#GO:0006810;system process#GO:0003008;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;action potential#GO:0001508;sodium ion transport#GO:0006814;sensory perception of pain#GO:0019233;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;sensory perception#GO:0007600;nervous system process#GO:0050877;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG113643|UniProtKB=T1EFU6 T1EFU6 20195448 PTHR47958:SF90 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX5-RELATED helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG157894|UniProtKB=T1EMH4 T1EMH4 20197774 PTHR13861:SF2 VACUOLAR ATP SYNTHASE SUBUNIT F V-TYPE PROTON ATPASE SUBUNIT F membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG183764|UniProtKB=T1FK61 T1FK61 20209210 PTHR31882:SF11 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER HDA1 COMPLEX SUBUNIT 2 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 HELRO|EnsemblGenome=HelroG104598|UniProtKB=T1EDM5 T1EDM5 20194677 PTHR15592:SF18 MATRIN 3/NUCLEAR PROTEIN 220-RELATED SMOOTH, ISOFORM T RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG182753|UniProtKB=T1FIP2 T1FIP2 20208691 PTHR17490:SF16 SUA5 THREONYLCARBAMOYL-AMP SYNTHASE transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;tRNA binding#GO:0000049;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 gene expression#GO:0010467;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;regulation of biological quality#GO:0065008;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG174388|UniProtKB=T1F826 T1F826 20204975 PTHR47027:SF32 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178280|UniProtKB=T1FD11 T1FD11 20206710 PTHR19282:SF551 TETRASPANIN TETRASPANIN-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177541|UniProtKB=T1FBU9 T1FBU9 20206298 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG67876|UniProtKB=T1FZ67 T1FZ67 20214115 PTHR24343:SF594 SERINE/THREONINE KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179479|UniProtKB=T1FER9 T1FER9 20207318 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG176448|UniProtKB=T1FAI4 T1FAI4 20205833 PTHR13244:SF7 ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10 plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;inner dynein arm assembly#GO:0036159;organelle assembly#GO:0070925 centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centriolar satellite#GO:0034451;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG89193|UniProtKB=T1G799 T1G799 20216946 PTHR45630:SF23 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE polyamine transmembrane transporter activity#GO:0015203;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;nitrogen compound transport#GO:0071705;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074 membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG168651|UniProtKB=T1F0U2 T1F0U2 20202442 PTHR10361:SF75 SODIUM-BILE ACID COTRANSPORTER SUBFAMILY NOT NAMED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG76379|UniProtKB=T1G2J3 T1G2J3 20215291 PTHR43313:SF50 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C RETINOL DEHYDROGENASE 7 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193750|UniProtKB=T1FVB4 T1FVB4 20212760 PTHR28625:SF1 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of organelle assembly#GO:1902115;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;regulation of cell projection organization#GO:0031344;regulation of cilium assembly#GO:1902017;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;regulation of microtubule-based process#GO:0032886;positive regulation of cellular component organization#GO:0051130;positive regulation of cell projection organization#GO:0031346;positive regulation of organelle organization#GO:0010638;regulation of cell projection assembly#GO:0060491 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG108569|UniProtKB=T1EEK4 T1EEK4 20195006 PTHR13218:SF8 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11 protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003 RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;transferase complex#GO:1990234;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HELRO|EnsemblGenome=HelroG159906|UniProtKB=T1EPJ4 T1EPJ4 20198494 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66271|UniProtKB=T1FYI9 T1FYI9 20213887 PTHR44566:SF1 TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN WD REPEAT-CONTAINING PROTEIN 25 HELRO|EnsemblGenome=HelroG182715|UniProtKB=T1FIM8 T1FIM8 20208677 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG184015|UniProtKB=T1FKF4 T1FKF4 20209303 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161584|UniProtKB=T1ERN4 T1ERN4 20199234 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156069|UniProtKB=T1ELR3 T1ELR3 20197513 PTHR11431:SF75 FERRITIN FERRITIN ferrous iron binding#GO:0008198;iron ion binding#GO:0005506;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 storage protein#PC00210 HELRO|EnsemblGenome=HelroG113558|UniProtKB=T1EFT6 T1EFT6 20195438 PTHR11247:SF81 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 PALMITOYL-PROTEIN THIOESTERASE 1 thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;palmitoyl hydrolase activity#GO:0098599;catalytic activity, acting on a protein#GO:0140096 nervous system development#GO:0007399;endocytosis#GO:0006897;multicellular organismal process#GO:0032501;transport#GO:0006810;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;establishment of localization#GO:0051234;anatomical structure development#GO:0048856;import into cell#GO:0098657;multicellular organism development#GO:0007275;localization#GO:0051179 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG130200|UniProtKB=T1EHT3 T1EHT3 20196133 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 homeostatic process#GO:0042592;metal ion transport#GO:0030001;regulation of cytosolic calcium ion concentration#GO:0051480;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878 monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG68096|UniProtKB=T1FZA2 T1FZA2 20214150 PTHR18884:SF130 SEPTIN SEPTIN hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;macromolecule localization#GO:0033036;biological regulation#GO:0065007;intracellular protein localization#GO:0008104;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cell cycle process#GO:0022402;cell division#GO:0051301;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;cytokinesis#GO:0000910;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;cytoskeleton-dependent cytokinesis#GO:0061640;regulation of secretion#GO:0051046;localization#GO:0051179 organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell cortex#GO:0005938;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;transport vesicle#GO:0030133;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell periphery#GO:0071944;cell junction#GO:0030054;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HELRO|EnsemblGenome=HelroG192372|UniProtKB=T1FTV6 T1FTV6 20212253 PTHR14700:SF0 PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;regulation of RNA metabolic process#GO:0051252 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155811|UniProtKB=T1ELM6 T1ELM6 20197476 PTHR12434:SF6 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183308|UniProtKB=T1FJF9 T1FJF9 20208958 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG183468|UniProtKB=T1FJQ3 T1FJQ3 20209052 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG183432|UniProtKB=T1FJN0 T1FJN0 20209029 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64903|UniProtKB=T1FY09 T1FY09 20213707 PTHR43730:SF1 BETA-MANNOSIDASE BETA-MANNOSIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;glycoprotein metabolic process#GO:0009100;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157787|UniProtKB=T1EMF7 T1EMF7 20197757 PTHR43521:SF9 ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG190322|UniProtKB=T1FRW8 T1FRW8 20211565 PTHR13140:SF860 MYOSIN MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG177251|UniProtKB=T1FBE8 T1FBE8 20206147 PTHR11046:SF31 OLIGORIBONUCLEASE, MITOCHONDRIAL THAP9-LIKE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG168657|UniProtKB=T1F0U3 T1F0U3 20202443 PTHR46251:SF3 RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3 RUN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73487|UniProtKB=T1G1E3 T1G1E3 20214891 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biological process#GO:0048519;negative regulation of macromolecule biosynthetic process#GO:0010558 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG75183|UniProtKB=T1G223 T1G223 20215121 PTHR46172:SF1 DNA POLYMERASE EPSILON SUBUNIT 3 DNA POLYMERASE EPSILON SUBUNIT 3 DNA binding#GO:0003677;chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;DNA strand elongation involved in DNA replication#GO:0006271;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;DNA replication#GO:0006260;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular protein-containing complex#GO:0140535;epsilon DNA polymerase complex#GO:0008622;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ISWI-type complex#GO:0031010 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG194984|UniProtKB=T1FWM5 T1FWM5 20213220 PTHR11388:SF100 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER transporter#PC00227 HELRO|EnsemblGenome=HelroG165359|UniProtKB=T1EWM9 T1EWM9 20200979 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162194|UniProtKB=T1ESC3 T1ESC3 20199473 PTHR11829:SF142 FORKHEAD BOX PROTEIN FORK-HEAD DOMAIN-CONTAINING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG90481|UniProtKB=T1G7S0 T1G7S0 20217117 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG164023|UniProtKB=T1EUS5 T1EUS5 20200325 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG174450|UniProtKB=T1F850 T1F850 20204999 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG189836|UniProtKB=T1FRE7 T1FRE7 20211394 PTHR13371:SF0 GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN CENTROSOMAL PROTEIN OF 104 KDA cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG78824|UniProtKB=T1G3G1 T1G3G1 20215609 PTHR46473:SF29 GH08155P LD45603P HELRO|EnsemblGenome=HelroG177463|UniProtKB=T1FBQ5 T1FBQ5 20206254 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194865|UniProtKB=T1FWI1 T1FWI1 20213176 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155605|UniProtKB=T1ELJ5 T1ELJ5 20197445 PTHR11028:SF6 VACUOLAR ATP SYNTHASE SUBUNIT AC39 V-TYPE PROTON ATPASE SUBUNIT D 1 monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 cellular localization#GO:0051641;localization#GO:0051179;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular transport#GO:0046907;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;vacuolar transport#GO:0007034;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 lytic vacuole#GO:0000323;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;proton-transporting two-sector ATPase complex#GO:0016469;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;early endosome#GO:0005769;ATPase dependent transmembrane transport complex#GO:0098533;intracellular organelle#GO:0043229;endosome#GO:0005768;ATPase complex#GO:1904949;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;endomembrane system#GO:0012505;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;cation-transporting ATPase complex#GO:0090533;plasma membrane protein complex#GO:0098797 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG101525|UniProtKB=T1ED52 T1ED52 20194504 PTHR16189:SF0 TRANSMEMBRANE PROTEIN 104-RELATED SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 12-RELATED HELRO|EnsemblGenome=HelroG186840|UniProtKB=T1FP41 T1FP41 20210588 PTHR19375:SF582 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED ribonucleoside triphosphate phosphatase activity#GO:0017111;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein refolding#GO:0042026;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 Hsp70 family chaperone#PC00027;chaperone#PC00072 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG156498|UniProtKB=T1ELX6 T1ELX6 20197576 PTHR47958:SF26 ATP-DEPENDENT RNA HELICASE DBP3 EUKARYOTIC INITIATION FACTOR 4A-III RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 organelle lumen#GO:0043233;spliceosomal complex#GO:0005681;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG193621|UniProtKB=T1FV69 T1FV69 20212715 PTHR10912:SF7 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cyclase#PC00079;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG72148|UniProtKB=T1G0W5 T1G0W5 20214713 PTHR12416:SF2 RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RRNA-PROCESSING PROTEIN FCF1 HOMOLOG biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG164427|UniProtKB=T1EVE6 T1EVE6 20200546 PTHR19359:SF14 CYTOCHROME B5 CYTOCHROME B5 binding#GO:0005488;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906 intracellular organelle#GO:0043229;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG165069|UniProtKB=T1EW89 T1EW89 20200839 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108341|UniProtKB=T1EEI3 T1EEI3 20194985 PTHR11871:SF0 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772 cytosol#GO:0005829;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protein phosphatase#PC00195 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG192596|UniProtKB=T1FU41 T1FU41 20212337 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;tissue development#GO:0009888;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;neuron projection development#GO:0031175;axon development#GO:0061564;axon guidance#GO:0007411;cellular process#GO:0009987 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG194586|UniProtKB=T1FW82 T1FW82 20213078 PTHR12424:SF8 TWEETY-RELATED PROTEIN TWEETY HOMOLOG 1 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG186768|UniProtKB=T1FP33 T1FP33 20210580 PTHR23420:SF31 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE-LIKE 1-RELATED catalytic activity#GO:0003824;hydrolase activity#GO:0016787 purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;purine-containing compound metabolic process#GO:0072521;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG91786|UniProtKB=T1G889 T1G889 20217286 PTHR23339:SF129 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE CELL DIVISION CYCLE 14, ISOFORM A catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 organelle assembly#GO:0070925;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;regulation of cell cycle phase transition#GO:1901987;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of cell cycle#GO:0045787 microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG194192|UniProtKB=T1FVS4 T1FVS4 20212920 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG131512|UniProtKB=T1EHV9 T1EHV9 20196159 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;macromolecule metabolic process#GO:0043170;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleotide-sugar metabolic process#GO:0009225;regulation of nucleobase-containing compound metabolic process#GO:0019219;ribonucleotide metabolic process#GO:0009259;regulation of cellular response to stress#GO:0080135;nucleotide metabolic process#GO:0009117;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;regulation of DNA metabolic process#GO:0051052;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosidase#PC00110 HELRO|EnsemblGenome=HelroG158630|UniProtKB=T1EN15 T1EN15 20197965 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG185164|UniProtKB=T1FMG7 T1FMG7 20210016 PTHR36300:SF1 RAW, ISOFORM A RAW, ISOFORM A cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG165909|UniProtKB=T1EXF8 T1EXF8 20201258 PTHR13434:SF0 PROTEIN CASC3 PROTEIN CASC3 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG95474|UniProtKB=T1G961 T1G961 20217608 PTHR12480:SF6 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;sequence-specific DNA binding#GO:0043565;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;binding#GO:0005488;nucleic acid binding#GO:0003676;dioxygenase activity#GO:0051213;DNA binding#GO:0003677 positive regulation of cellular component organization#GO:0051130;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of translation#GO:0045727;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of protein-containing complex disassembly#GO:0043244;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83915|UniProtKB=T1G5B8 T1G5B8 20216265 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;macromolecular conformation isomerase activity#GO:0120543 cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA processing#GO:0006397;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;nucleic acid transport#GO:0050657;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nuclear transport#GO:0051169;nuclear export#GO:0051168;RNA splicing, via transesterification reactions#GO:0000375;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;RNA biosynthetic process#GO:0032774;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;macromolecule biosynthetic process#GO:0009059 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG191066|UniProtKB=T1FSK0 T1FSK0 20211797 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG105607|UniProtKB=T1EDW6 T1EDW6 20194768 PTHR12153:SF15 SELENOPROTEIN O PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG65885|UniProtKB=T1FYE1 T1FYE1 20213839 PTHR15967:SF1 E2F-ASSOCIATED PHOSPHOPROTEIN E2F-ASSOCIATED PHOSPHOPROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG192060|UniProtKB=T1FTJ9 T1FTJ9 20212146 PTHR12582:SF50 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC-5 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HELRO|EnsemblGenome=HelroG102315|UniProtKB=T1ED94 T1ED94 20194546 PTHR15301:SF12 INSULIN-INDUCED GENE 1 INSULIN-INDUCED GENE PROTEIN regulation of cell communication#GO:0010646;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;biological regulation#GO:0065007;biosynthetic process#GO:0009058;response to peptide hormone#GO:0043434;SREBP signaling pathway#GO:0032933;lipid biosynthetic process#GO:0008610;negative regulation of response to stimulus#GO:0048585;secondary alcohol biosynthetic process#GO:1902653;cholesterol metabolic process#GO:0008203;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;secondary alcohol metabolic process#GO:1902652;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;cellular localization#GO:0051641;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;cholesterol biosynthetic process#GO:0006695;cellular response to lipid#GO:0071396;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;alcohol metabolic process#GO:0006066;cellular response to peptide hormone stimulus#GO:0071375;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;regulation of signal transduction#GO:0009966;cellular response to nitrogen compound#GO:1901699;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;regulation of response to stress#GO:0080134;signaling#GO:0023052;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;response to endogenous stimulus#GO:0009719;regulation of cellular response to stress#GO:0080135;negative regulation of intracellular signal transduction#GO:1902532;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to lipid#GO:0033993;response to stress#GO:0006950;response to hormone#GO:0009725;metabolic process#GO:0008152 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG192035|UniProtKB=T1FTJ0 T1FTJ0 20212137 PTHR47020:SF1 HILLARIN HILLARIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG151008|UniProtKB=T1EKI1 T1EKI1 20197081 PTHR43968:SF6 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA antioxidant activity#GO:0016209;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;glutathione transferase activity#GO:0004364 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG158781|UniProtKB=T1EN92 T1EN92 20198042 PTHR23317:SF76 DEDICATOR OF CYTOKINESIS DOCK LD20667P molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG116983|UniProtKB=T1EGJ1 T1EGJ1 20195693 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE FI04477P-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;lipid modification#GO:0030258;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phospholipid dephosphorylation#GO:0046839;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154;dephosphorylation#GO:0016311 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194811|UniProtKB=T1FWF8 T1FWF8 20213153 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG172937|UniProtKB=T1F660 T1F660 20204309 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109002|UniProtKB=T1EEP8 T1EEP8 20195050 PTHR13005:SF4 CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG190514|UniProtKB=T1FS24 T1FS24 20211621 PTHR15723:SF0 CARBOHYDRATE SULFOTRANSFERASE 15 CARBOHYDRATE SULFOTRANSFERASE 15 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule biosynthetic process#GO:0044283;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate biosynthetic process#GO:0016051;monosaccharide biosynthetic process#GO:0046364;carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;hexose biosynthetic process#GO:0019319;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106795|UniProtKB=T1EE50 T1EE50 20194852 PTHR23152:SF38 2-OXOGLUTARATE DEHYDROGENASE 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG167821|UniProtKB=T1EZU2 T1EZU2 20202092 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192110|UniProtKB=T1FTL0 T1FTL0 20212157 PTHR47969:SF15 CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microtubule motor activity#GO:0003777 cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;spindle elongation#GO:0051231;chromosome segregation#GO:0007059;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule cytoskeleton organization#GO:0000226 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG191557|UniProtKB=T1FT29 T1FT29 20211976 PTHR14166:SF17 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO-GAP DOMAIN-CONTAINING PROTEIN enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG168494|UniProtKB=T1F0M8 T1F0M8 20202378 PTHR12905:SF0 METALLOPHOSPHOESTERASE CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 metabolite interconversion enzyme#PC00262;hydrolase#PC00121;esterase#PC00097 HELRO|EnsemblGenome=HelroG177262|UniProtKB=T1FBF2 T1FBF2 20206151 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176276|UniProtKB=T1FAC9 T1FAC9 20205778 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG194041|UniProtKB=T1FVL6 T1FVL6 20212862 PTHR12460:SF0 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN CID DOMAIN-CONTAINING PROTEIN-RELATED enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG154121|UniProtKB=T1ELD8 T1ELD8 20197388 PTHR21569:SF47 RIBOSOMAL PROTEIN S9 SMALL RIBOSOMAL SUBUNIT PROTEIN US9M RNA binding#GO:0003723;structural molecule activity#GO:0005198;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735 ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG111253|UniProtKB=T1EF99 T1EF99 20195251 PTHR10027:SF41 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN SLOWPOKE 2, ISOFORM D channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG86081|UniProtKB=T1G670 T1G670 20216567 PTHR46473:SF29 GH08155P LD45603P HELRO|EnsemblGenome=HelroG64223|UniProtKB=T1FXR5 T1FXR5 20213613 PTHR23349:SF68 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FI14601P sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG110638|UniProtKB=T1EF38 T1EF38 20195190 PTHR48207:SF3 SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE SUCCINYL-COA:GLUTARATE COA-TRANSFERASE transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Carnitine metabolism#P02733>Carnitine dehydratase#P02866;Coenzyme A linked carnitine metabolism#P02732>L-carnitine dehydratase#P02864 HELRO|EnsemblGenome=HelroG184465|UniProtKB=T1FL93 T1FL93 20209592 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81865|UniProtKB=T1G4J8 T1G4J8 20215996 PTHR24033:SF151 EGF-LIKE DOMAIN-CONTAINING PROTEIN NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2 HELRO|EnsemblGenome=HelroG191636|UniProtKB=T1FT56 T1FT56 20212003 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG176383|UniProtKB=T1FAG7 T1FAG7 20205816 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193110|UniProtKB=T1FUM7 T1FUM7 20212523 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76590|UniProtKB=T1G2L9 T1G2L9 20215317 PTHR10978:SF5 SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic respiration#GO:0009060;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;generation of precursor metabolites and energy#GO:0006091 respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;respiratory chain complex II (succinate dehydrogenase)#GO:0045273 dehydrogenase#PC00092 TCA cycle#P00051>Succinate Dehydrogenase#P01273 HELRO|EnsemblGenome=HelroG161724|UniProtKB=T1ERU2 T1ERU2 20199292 PTHR35069:SF1 PROTEIN C9ORF135 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 95 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG80911|UniProtKB=T1G471 T1G471 20215869 PTHR48013:SF9 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1 protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>MEK1-2#P00559;Endothelin signaling pathway#P00019>MEK#P00572;PDGF signaling pathway#P00047>MEK#P01162;FGF signaling pathway#P00021>MEK1-2#P00642;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG70673|UniProtKB=T1G0A5 T1G0A5 20214503 PTHR10159:SF540 DUAL SPECIFICITY PROTEIN PHOSPHATASE RHODANESE DOMAIN-CONTAINING DUAL SPECIFICITY PROTEIN PHOSPHATASE-RELATED catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG116148|UniProtKB=T1EGD3 T1EGD3 20195635 PTHR23182:SF1 BREAKPOINT CLUSTER REGION PROTEIN BCR RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of trans-synaptic signaling#GO:0099177;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 cell junction#GO:0030054;postsynaptic density#GO:0014069;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;synapse#GO:0045202;glutamatergic synapse#GO:0098978;organelle#GO:0043226;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944 G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG163153|UniProtKB=T1ETQ6 T1ETQ6 20199956 PTHR24034:SF111 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE64043P extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG98385|UniProtKB=T1G9M2 T1G9M2 20217768 PTHR10985:SF138 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;pattern specification process#GO:0007389;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;Notch signaling pathway#GO:0007219;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organism development#GO:0007275;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cell surface receptor signaling pathway#GO:0007166 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG191179|UniProtKB=T1FSP8 T1FSP8 20211845 PTHR45716:SF2 BITESIZE, ISOFORM I BITESIZE, ISOFORM I signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;transport#GO:0006810;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;exocytosis#GO:0006887;secretion by cell#GO:0032940 cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG92217|UniProtKB=T1G8D0 T1G8D0 20217327 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG74633|UniProtKB=T1G1T4 T1G1T4 20215032 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG188924|UniProtKB=T1FQH4 T1FQH4 20211071 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 HELRO|EnsemblGenome=HelroG186994|UniProtKB=T1FP51 T1FP51 20210598 PTHR23238:SF26 RNA BINDING PROTEIN GH13594P-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192257|UniProtKB=T1FTR8 T1FTR8 20212215 PTHR12975:SF6 TRANSPORT PROTEIN TRAPP TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;TRAPP complex#GO:0030008;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG90604|UniProtKB=T1G7T4 T1G7T4 20217131 PTHR12027:SF101 WNT RELATED PROTEIN WNT-4 protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664 cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;system development#GO:0048731;cell fate commitment#GO:0045165 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HELRO|EnsemblGenome=HelroG186002|UniProtKB=T1FNJ2 T1FNJ2 20210389 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;DNA exonuclease activity#GO:0004529;DNA endonuclease activity#GO:0004520;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;3'-5'-DNA exonuclease activity#GO:0008296;exonuclease activity#GO:0004527;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;hydrolase activity#GO:0016787 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;base-excision repair#GO:0006284;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 HELRO|EnsemblGenome=HelroG102089|UniProtKB=T1ED79 T1ED79 20194531 PTHR45697:SF3 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG167737|UniProtKB=T1EZQ6 T1EZQ6 20202056 PTHR10476:SF40 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 2B membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181891|UniProtKB=T1FHF8 T1FHF8 20208257 PTHR23147:SF133 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 10 cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG188530|UniProtKB=T1FQ35 T1FQ35 20210932 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176320|UniProtKB=T1FAE0 T1FAE0 20205789 PTHR24238:SF83 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG187209|UniProtKB=T1FP77 T1FP77 20210624 PTHR11937:SF37 ACTIN ACTIN-RELATED PROTEIN 2 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198;cytoskeletal protein binding#GO:0008092 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cytoskeleton organization#GO:0007010 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;cell periphery#GO:0071944;cell cortex#GO:0005938;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG167520|UniProtKB=T1EZG2 T1EZG2 20201962 PTHR34487:SF1 ACYL-ACP THIOESTERASE ACYL-ACP THIOESTERASE HELRO|EnsemblGenome=HelroG168397|UniProtKB=T1F0J6 T1F0J6 20202346 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185069|UniProtKB=T1FMC9 T1FMC9 20209978 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG186197|UniProtKB=T1FNT0 T1FNT0 20210477 PTHR10263:SF18 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 21 KDA PROTEOLIPID SUBUNIT C'' cellular anatomical structure#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG75876|UniProtKB=T1G2B9 T1G2B9 20215217 PTHR13166:SF7 PROTEIN C6ORF149 LYR MOTIF-CONTAINING PROTEIN 4 cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;iron-sulfur cluster assembly#GO:0016226;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;sulfurtransferase complex#GO:1990228;cytosol#GO:0005829;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG91624|UniProtKB=T1G865 T1G865 20217262 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174575|UniProtKB=T1F896 T1F896 20205045 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG87093|UniProtKB=T1G6L5 T1G6L5 20216712 PTHR22957:SF333 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 25 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of metabolic process#GO:0019222;regulation of protein-containing complex disassembly#GO:0043244;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of autophagosome maturation#GO:1901096;regulation of catabolic process#GO:0009894;regulation of macroautophagy#GO:0016241 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;autophagosome#GO:0005776;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG150188|UniProtKB=T1EKE7 T1EKE7 20197047 PTHR24208:SF168 LIM/HOMEOBOX PROTEIN LHX PROTEIN APTEROUS RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG159772|UniProtKB=T1EPE0 T1EPE0 20198440 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG87639|UniProtKB=T1G6T4 T1G6T4 20216781 PTHR13250:SF1 TF-1 CELL APOPTOSIS RELATED PROTEIN-15 PROGRAMMED CELL DEATH PROTEIN 10 protein binding#GO:0005515;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG92061|UniProtKB=T1G8B8 T1G8B8 20217315 PTHR14969:SF13 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE AT30094P hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;dephosphorylation#GO:0016311 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183850|UniProtKB=T1FK96 T1FK96 20209245 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG179341|UniProtKB=T1FEK7 T1FEK7 20207256 PTHR13559:SF1 INTRACELLULAR TRAFFIC PROTEIN-RELATED PROTEIN FUZZY HOMOLOG cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 HELRO|EnsemblGenome=HelroG81835|UniProtKB=T1G4J4 T1G4J4 20215992 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG182354|UniProtKB=T1FI38 T1FI38 20208487 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;macromolecule catabolic process#GO:0009057;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nuclear mRNA surveillance#GO:0071028;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA metabolic process#GO:0016073 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG182817|UniProtKB=T1FIS9 T1FIS9 20208728 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG188534|UniProtKB=T1FQ38 T1FQ38 20210935 PTHR46298:SF1 ANDROGLOBIN ANDROGLOBIN plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 HELRO|EnsemblGenome=HelroG170842|UniProtKB=T1F3I1 T1F3I1 20203380 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173029|UniProtKB=T1F6A1 T1F6A1 20204350 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG184932|UniProtKB=T1FM64 T1FM64 20209913 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG193868|UniProtKB=T1FVF5 T1FVF5 20212801 PTHR46189:SF1 LD41958P LD41958P cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG165479|UniProtKB=T1EWV8 T1EWV8 20201058 PTHR24403:SF67 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG188488|UniProtKB=T1FQ17 T1FQ17 20210914 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED INHIBITOR 1, PUTATIVE-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG114110|UniProtKB=T1EFZ0 T1EFZ0 20195492 PTHR11559:SF370 CARBOXYLESTERASE CARBOXYLIC ESTER HYDROLASE-RELATED esterase#PC00097 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067 HELRO|EnsemblGenome=HelroG94141|UniProtKB=T1G8Z1 T1G8Z1 20217538 PTHR16263:SF4 TETRATRICOPEPTIDE REPEAT PROTEIN 38 TETRATRICOPEPTIDE REPEAT PROTEIN 38 HELRO|EnsemblGenome=HelroG87651|UniProtKB=T1G6T7 T1G6T7 20216784 PTHR10972:SF141 OXYSTEROL-BINDING PROTEIN-RELATED PH DOMAIN-CONTAINING PROTEIN sterol binding#GO:0032934;binding#GO:0005488;steroid binding#GO:0005496;lipid binding#GO:0008289 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG181283|UniProtKB=T1FGU3 T1FGU3 20208042 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG168783|UniProtKB=T1F0Y7 T1F0Y7 20202487 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG93125|UniProtKB=T1G8U0 T1G8U0 20217487 PTHR24390:SF271 ZINC FINGER PROTEIN FI23536P1-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG159485|UniProtKB=T1EP32 T1EP32 20198332 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152761|UniProtKB=T1EKW7 T1EKW7 20197217 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular developmental process#GO:0048869;plasma membrane bounded cell projection assembly#GO:0120031;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281 organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG163106|UniProtKB=T1ETN6 T1ETN6 20199936 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG185258|UniProtKB=T1FMK4 T1FMK4 20210053 PTHR10965:SF0 60S RIBOSOMAL PROTEIN L38 LARGE RIBOSOMAL SUBUNIT PROTEIN EL38 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG104891|UniProtKB=T1EDP1 T1EDP1 20194693 PTHR45745:SF1 PHOSPHOMANNOMUTASE 45A PHOSPHOGLUCOMUTASE 2A-RELATED isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;intramolecular phosphotransferase activity#GO:0016868 small molecule biosynthetic process#GO:0044283;purine nucleoside metabolic process#GO:0042278;metabolic process#GO:0008152;purine-containing compound biosynthetic process#GO:0072522;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116 isomerase#PC00135;metabolite interconversion enzyme#PC00262;mutase#PC00160 HELRO|EnsemblGenome=HelroG74174|UniProtKB=T1G1N0 T1G1N0 20214978 PTHR24348:SF79 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED AUTOPHAGY-RELATED 1, ISOFORM B catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;neuron projection development#GO:0031175;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;axon extension#GO:0048675;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;metabolic process#GO:0008152;neuron differentiation#GO:0030182;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell growth#GO:0016049;cell projection morphogenesis#GO:0048858;autophagosome assembly#GO:0000045;regulation of autophagy#GO:0010506;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;process utilizing autophagic mechanism#GO:0061919;neuron development#GO:0048666;neuron projection extension#GO:1990138;axonogenesis#GO:0007409;developmental growth involved in morphogenesis#GO:0060560;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;axon development#GO:0061564;reticulophagy#GO:0061709;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;macroautophagy#GO:0016236;plasma membrane bounded cell projection organization#GO:0120036;autophagy of mitochondrion#GO:0000422;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;mitophagy#GO:0000423;cellular developmental process#GO:0048869;developmental growth#GO:0048589;regulation of catabolic process#GO:0009894;neurogenesis#GO:0022008;response to starvation#GO:0042594;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;developmental cell growth#GO:0048588;piecemeal microautophagy of the nucleus#GO:0034727;organelle assembly#GO:0070925;anatomical structure development#GO:0048856;vacuole organization#GO:0007033;system development#GO:0048731 cytosol#GO:0005829;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG168768|UniProtKB=T1F0Y0 T1F0Y0 20202480 PTHR10838:SF34 SYNAPTOGYRIN SYNAPTOGYRIN cytoplasm#GO:0005737;endomembrane system#GO:0012505;transport vesicle#GO:0030133;presynapse#GO:0098793;secretory vesicle#GO:0099503;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG173987|UniProtKB=T1F7G3 T1F7G3 20204762 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185711|UniProtKB=T1FN66 T1FN66 20210264 PTHR21141:SF5 60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN P2 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG169003|UniProtKB=T1F189 T1F189 20202589 PTHR37002:SF10 AGAP007005-PA F-BOX_LRR-REPEAT PROTEIN 15-LIKE LEUCIN RICH REPEAT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106256|UniProtKB=T1EE11 T1EE11 20194813 PTHR16214:SF3 TRANSMEMBRANE PROTEIN 260 PROTEIN O-MANNOSYL-TRANSFERASE TMEM260 HELRO|EnsemblGenome=HelroG192371|UniProtKB=T1FTV5 T1FTV5 20212252 PTHR23235:SF204 KRUEPPEL-LIKE TRANSCRIPTION FACTOR ZINC FINGER PROTEIN 235-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG111676|UniProtKB=T1EFD6 T1EFD6 20195288 PTHR12566:SF19 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB TRANSLATIONAL REGULATOR ORB2 translation regulator activity#GO:0045182;mRNA 3'-UTR binding#GO:0003730;translation factor activity#GO:0180051;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;spermatogenesis#GO:0007283;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;male gamete generation#GO:0048232;negative regulation of macromolecule metabolic process#GO:0010605;regulation of translation#GO:0006417;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;negative regulation of translation#GO:0017148;negative regulation of metabolic process#GO:0009892;reproductive process#GO:0022414;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;developmental process involved in reproduction#GO:0003006;negative regulation of gene expression#GO:0010629 neuron projection#GO:0043005;nucleus#GO:0005634;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG194130|UniProtKB=T1FVQ3 T1FVQ3 20212899 PTHR10131:SF165 TNF RECEPTOR ASSOCIATED FACTOR E3 UBIQUITIN-PROTEIN LIGASE NRDP1 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192693|UniProtKB=T1FU73 T1FU73 20212369 PTHR23152:SF4 2-OXOGLUTARATE DEHYDROGENASE 2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;cellular process#GO:0009987;tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;cytosol#GO:0005829;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG172218|UniProtKB=T1F554 T1F554 20203953 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG190837|UniProtKB=T1FSC6 T1FSC6 20211723 PTHR15708:SF4 ACTIN BUNDLING/MISSING IN METASTASIS-RELATED FI21477P1-RELATED cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG156641|UniProtKB=T1ELZ1 T1ELZ1 20197591 PTHR12941:SF10 ER MEMBRANE PROTEIN COMPLEX ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977;molecular carrier activity#GO:0140104 intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;EMC complex#GO:0072546;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG76363|UniProtKB=T1G2J0 T1G2J0 20215288 PTHR23235:SF194 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG190530|UniProtKB=T1FS28 T1FS28 20211625 PTHR14527:SF2 PROTEIN MIS12 HOMOLOG PROTEIN MIS12 HOMOLOG cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;mitotic cell cycle#GO:0000278;nuclear division#GO:0000280;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;organelle fission#GO:0048285;kinetochore organization#GO:0051383 chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HELRO|EnsemblGenome=HelroG163951|UniProtKB=T1EUN3 T1EUN3 20200283 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166233|UniProtKB=T1EXX5 T1EXX5 20201425 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG64563|UniProtKB=T1FXW5 T1FXW5 20213663 PTHR19134:SF449 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175225|UniProtKB=T1F915 T1F915 20205314 PTHR24248:SF215 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 84 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG147404|UniProtKB=T1EK00 T1EK00 20196900 PTHR19965:SF35 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194312|UniProtKB=T1FVX1 T1FVX1 20212967 PTHR24416:SF349 TYROSINE-PROTEIN KINASE RECEPTOR INACTIVE TYROSINE-PROTEIN KINASE RYK transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181763|UniProtKB=T1FHA8 T1FHA8 20208207 PTHR12460:SF0 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN CID DOMAIN-CONTAINING PROTEIN-RELATED RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG192410|UniProtKB=T1FTX5 T1FTX5 20212272 PTHR17920:SF3 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG160184|UniProtKB=T1EPY0 T1EPY0 20198630 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG127888|UniProtKB=T1EHJ5 T1EHJ5 20196045 PTHR13202:SF0 MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT SIGNAL PEPTIDASE COMPLEX SUBUNIT 1 primary metabolic process#GO:0044238;protein targeting#GO:0006605;protein metabolic process#GO:0019538;localization#GO:0051179;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of protein localization#GO:0045184;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;establishment of protein localization to endoplasmic reticulum#GO:0072599;metabolic process#GO:0008152;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;protein targeting to ER#GO:0045047 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;peptidase complex#GO:1905368;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090 protein modifying enzyme#PC00260;protease#PC00190 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG187486|UniProtKB=T1FPA1 T1FPA1 20210648 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cell communication#GO:0007154;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG64064|UniProtKB=T1FXN9 T1FXN9 20213587 PTHR12883:SF0 ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED PAT COMPLEX SUBUNIT CCDC47 organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;protein folding chaperone complex#GO:0101031;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG167419|UniProtKB=T1EZC3 T1EZC3 20201923 PTHR24026:SF141 FAT ATYPICAL CADHERIN-RELATED CADHERIN DOMAIN-CONTAINING PROTEIN anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG63764|UniProtKB=T1FXK1 T1FXK1 20213549 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG113026|UniProtKB=T1EFP7 T1EFP7 20195399 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG194828|UniProtKB=T1FWG5 T1FWG5 20213160 PTHR47958:SF216 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;reproductive process#GO:0022414;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;gamete generation#GO:0007276;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG163441|UniProtKB=T1EU20 T1EU20 20200070 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG76015|UniProtKB=T1G2E0 T1G2E0 20215238 PTHR12406:SF41 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED TRIACYLGLYCEROL LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triacylglycerol lipase activity#GO:0004806 primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;homeostatic process#GO:0042592;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;triglyceride catabolic process#GO:0019433;glycerolipid catabolic process#GO:0046503;lipid catabolic process#GO:0016042;cellular process#GO:0009987;neutral lipid catabolic process#GO:0046461;triglyceride metabolic process#GO:0006641;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638 intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG83374|UniProtKB=T1G549 T1G549 20216197 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG191439|UniProtKB=T1FSZ6 T1FSZ6 20211943 PTHR21286:SF0 NUCLEAR PORE COMPLEX PROTEIN NUP160 NUCLEAR PORE COMPLEX PROTEIN NUP160 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 ribonucleoprotein complex biogenesis#GO:0022613;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;ribosomal large subunit export from nucleus#GO:0000055;cellular component organization#GO:0016043;response to abiotic stimulus#GO:0009628;protein import into nucleus#GO:0006606;protein transport#GO:0015031;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;cellular response to stress#GO:0033554;ribosome biogenesis#GO:0042254;telomere tethering at nuclear periphery#GO:0034398;chromosome localization#GO:0050000;response to temperature stimulus#GO:0009266;protein export from nucleus#GO:0006611;gene expression#GO:0010467;response to chemical#GO:0042221;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;response to stress#GO:0006950;response to heat#GO:0009408;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular response to heat#GO:0034605;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;RNA localization#GO:0006403;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;nucleobase-containing compound transport#GO:0015931;cellular response to stimulus#GO:0051716;telomere localization#GO:0034397;nuclear export#GO:0051168;response to nitrogen compound#GO:1901698;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;organelle localization#GO:0051640;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;transport#GO:0006810;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HELRO|EnsemblGenome=HelroG96204|UniProtKB=T1G9A7 T1G9A7 20217654 PTHR12117:SF0 HISTONE ACETYLTRANSFERASE COMPLEX PROLYL 3-HYDROXYLASE OGFOD1 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;dioxygenase activity#GO:0051213;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of protein-containing complex disassembly#GO:0043244;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG91513|UniProtKB=T1G848 T1G848 20217245 PTHR11096:SF0 RNA 3' TERMINAL PHOSPHATE CYCLASE RNA 3'-TERMINAL PHOSPHATE CYCLASE ligase activity#GO:0016874;cyclase activity#GO:0009975;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG99003|UniProtKB=T1G9Q5 T1G9Q5 20217801 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG178809|UniProtKB=T1FDR8 T1FDR8 20206967 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG147997|UniProtKB=T1EK39 T1EK39 20196939 PTHR23235:SF58 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE PROTEIN 4 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG193368|UniProtKB=T1FUX4 T1FUX4 20212620 PTHR45868:SF80 HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED F15K9.8-RELATED HELRO|EnsemblGenome=HelroG167244|UniProtKB=T1EZ61 T1EZ61 20201861 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG81066|UniProtKB=T1G484 T1G484 20215882 PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical structure#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG82107|UniProtKB=T1G4M9 T1G4M9 20216027 PTHR47039:SF1 INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;localization#GO:0051179;system process#GO:0003008;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;ciliary base#GO:0097546;cilium#GO:0005929 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG191657|UniProtKB=T1FT66 T1FT66 20212013 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG112372|UniProtKB=T1EFJ1 T1EFJ1 20195343 PTHR12375:SF47 RNA-BINDING PROTEIN LUC7-RELATED LUC7-LIKE PROTEIN 3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA splice site recognition#GO:0006376;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685 HELRO|EnsemblGenome=HelroG154397|UniProtKB=T1ELE7 T1ELE7 20197397 PTHR10655:SF68 LYSOPHOSPHOLIPASE-RELATED PALMITOYL-PROTEIN HYDROLASE carboxylic ester hydrolase activity#GO:0052689;thiolester hydrolase activity#GO:0016790;lipase activity#GO:0016298;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;palmitoyl hydrolase activity#GO:0098599;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;catalytic activity, acting on a protein#GO:0140096 regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of localization#GO:0032879;regulation of transport#GO:0051049;negative regulation of cellular process#GO:0048523;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;negative regulation of protein transport#GO:0051224;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 phospholipase#PC00186;lipase#PC00143 HELRO|EnsemblGenome=HelroG183421|UniProtKB=T1FJM2 T1FJM2 20209021 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165062|UniProtKB=T1EW84 T1EW84 20200834 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191346|UniProtKB=T1FSW9 T1FSW9 20211916 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192589|UniProtKB=T1FU40 T1FU40 20212336 PTHR23163:SF0 RING FINGER PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE BRE1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG164062|UniProtKB=T1EUU9 T1EUU9 20200349 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191604|UniProtKB=T1FT43 T1FT43 20211990 PTHR22969:SF15 IKB KINASE FI05319P protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 positive regulation of response to external stimulus#GO:0032103;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;immune system process#GO:0002376;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;positive regulation of response to biotic stimulus#GO:0002833;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;positive regulation of biosynthetic process#GO:0009891;positive regulation of type I interferon production#GO:0032481;regulation of response to biotic stimulus#GO:0002831;positive regulation of cytokine production#GO:0001819;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193056|UniProtKB=T1FUK9 T1FUK9 20212505 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG193524|UniProtKB=T1FV29 T1FV29 20212675 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG193162|UniProtKB=T1FUP2 T1FUP2 20212538 PTHR15189:SF7 BRISC AND BRCA1-A COMPLEX MEMBER 2 BRISC AND BRCA1-A COMPLEX MEMBER 2 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nuclear protein-containing complex#GO:0140513;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG69097|UniProtKB=T1FZP6 T1FZP6 20214294 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG195027|UniProtKB=T1FWN9 T1FWN9 20213234 PTHR23113:SF312 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG186034|UniProtKB=T1FNK5 T1FNK5 20210402 PTHR43884:SF11 ACYL-COA DEHYDROGENASE VERY LONG-CHAIN ACYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;lipid binding#GO:0008289;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;lipid modification#GO:0030258;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG158535|UniProtKB=T1EMX6 T1EMX6 20197926 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;nuclear mRNA surveillance#GO:0071028;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;snRNA metabolic process#GO:0016073 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG169578|UniProtKB=T1F245 T1F245 20202895 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185615|UniProtKB=T1FN15 T1FN15 20210214 PTHR10266:SF3 CYTOCHROME C1 CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL monoatomic cation transmembrane transporter activity#GO:0008324;electron transfer activity#GO:0009055;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;oxidoreductase activity, acting on diphenols and related substances as donors#GO:0016679;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824 metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;electron transport chain#GO:0022900;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Huntington disease#P00029>Cytochrome c#P00785;FAS signaling pathway#P00020>CytochromeC#P00620;ATP synthesis#P02721>Cyt bc1#P02799 HELRO|EnsemblGenome=HelroG164284|UniProtKB=T1EV74 T1EV74 20200474 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG191759|UniProtKB=T1FTA3 T1FTA3 20212050 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG179366|UniProtKB=T1FEM0 T1FEM0 20207269 PTHR11616:SF338 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER symporter activity#GO:0015293;amino acid:sodium symporter activity#GO:0005283;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 organic acid transport#GO:0015849;amino acid transport#GO:0006865;transport#GO:0006810;carboxylic acid transport#GO:0046942;import into cell#GO:0098657;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;glycine transport#GO:0015816;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039;metal ion transport#GO:0030001 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG114157|UniProtKB=T1EFZ7 T1EFZ7 20195499 PTHR48021:SF1 FAMILY NOT NAMED MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG88222|UniProtKB=T1G701 T1G701 20216848 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG159919|UniProtKB=T1EPJ9 T1EPJ9 20198499 PTHR24058:SF135 DUAL SPECIFICITY PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184928|UniProtKB=T1FM62 T1FM62 20209911 PTHR12223:SF45 VESICULAR MANNOSE-BINDING LECTIN RE50040P small molecule binding#GO:0036094;binding#GO:0005488;monosaccharide binding#GO:0048029;carbohydrate binding#GO:0030246 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG67684|UniProtKB=T1FZ39 T1FZ39 20214087 PTHR15710:SF261 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE E3 UBIQUITIN TRANSFERASE positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;positive regulation of intracellular signal transduction#GO:1902533;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG174841|UniProtKB=T1F8J1 T1F8J1 20205140 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG161364|UniProtKB=T1ERE4 T1ERE4 20199144 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG195046|UniProtKB=T1FWP7 T1FWP7 20213242 PTHR13520:SF0 RAD50-INTERACTING PROTEIN 1 RINT-1 RAD50-INTERACTING PROTEIN 1 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG99580|UniProtKB=T1G9T8 T1G9T8 20217834 PTHR21706:SF15 TRANSMEMBRANE PROTEIN 65 LP09246P membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG108583|UniProtKB=T1EEK6 T1EEK6 20195008 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Cell cycle#P00013>Protein kinase subunit#P00482;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035 HELRO|EnsemblGenome=HelroG102934|UniProtKB=T1EDD3 T1EDD3 20194585 PTHR23323:SF24 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vesicle organization#GO:0016050;vacuole organization#GO:0007033;organelle fusion#GO:0048284;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;vesicle tethering complex#GO:0099023;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG140151|UniProtKB=T1EJ00 T1EJ00 20196550 PTHR31428:SF6 RGM DOMAIN FAMILY MEMBER DRAG-1 REPULSIVE GUIDANCE MOLECULE B HOMOLOG DRAG-1 coreceptor activity#GO:0015026;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG169280|UniProtKB=T1F1P9 T1F1P9 20202749 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73582|UniProtKB=T1G1G1 T1G1G1 20214909 PTHR28052:SF1 UPF0545 PROTEIN C22ORF39 SYNAPTIC PLASTICITY REGULATOR PANTS HELRO|EnsemblGenome=HelroG108208|UniProtKB=T1EEG9 T1EEG9 20194971 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HELRO|EnsemblGenome=HelroG90657|UniProtKB=T1G7U0 T1G7U0 20217137 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;epidermal growth factor receptor signaling pathway#GO:0007173;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;nervous system development#GO:0007399 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG84756|UniProtKB=T1G5N3 T1G5N3 20216380 PTHR11567:SF211 ACID PHOSPHATASE-RELATED ACID PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG183816|UniProtKB=T1FK86 T1FK86 20209235 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 HELRO|EnsemblGenome=HelroG110309|UniProtKB=T1EF12 T1EF12 20195164 PTHR24023:SF1137 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG73143|UniProtKB=T1G1A8 T1G1A8 20214856 PTHR23122:SF72 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68444|UniProtKB=T1FZE9 T1FZE9 20214197 PTHR10169:SF38 DNA TOPOISOMERASE/GYRASE DNA TOPOISOMERASE 2 ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097 meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;organelle fission#GO:0048285;cell cycle#GO:0007049;sister chromatid segregation#GO:0000819;meiosis I#GO:0007127;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;homologous recombination#GO:0035825;reproductive process#GO:0022414;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;chromosome segregation#GO:0007059;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;chromosome organization#GO:0051276;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634 DNA metabolism protein#PC00009 DNA replication#P00017>Top#P00530;DNA replication#P00017>DNA Topisomerase#P00536 HELRO|EnsemblGenome=HelroG130575|UniProtKB=T1EHU3 T1EHU3 20196143 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230 chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG142940|UniProtKB=T1EJ82 T1EJ82 20196632 PTHR45080:SF8 CONTACTIN 5 NEURAL CELL ADHESION MOLECULE 1 ISOFORM X1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell junction organization#GO:0034330;cell adhesion#GO:0007155;synapse organization#GO:0050808;cellular component organization or biogenesis#GO:0071840 axon#GO:0030424;neuronal cell body#GO:0043025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell body#GO:0044297;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG67423|UniProtKB=T1FZ07 T1FZ07 20214055 PTHR46479:SF1 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2 protein binding#GO:0005515;binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;organelle localization#GO:0051640;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome localization#GO:0032418 membraneless organelle#GO:0043228;BLOC-1 complex#GO:0031083;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG88702|UniProtKB=T1G756 T1G756 20216903 PTHR23516:SF23 SAM (S-ADENOSYL METHIONINE) TRANSPORTER MOLYBDATE-ANION TRANSPORTER transporter#PC00227 HELRO|EnsemblGenome=HelroG191307|UniProtKB=T1FSV3 T1FSV3 20211900 PTHR24023:SF1131 COLLAGEN ALPHA COLLAGEN TYPE VII ALPHA 1 CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG167604|UniProtKB=T1EZJ4 T1EZJ4 20201994 PTHR11447:SF16 CELLULAR TUMOR ANTIGEN P53 P53, ISOFORM B binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;DNA damage response#GO:0006974;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;cell death#GO:0008219;cellular response to stimulus#GO:0051716;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of apoptotic process#GO:0042981;positive regulation of macromolecule metabolic process#GO:0010604;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;intrinsic apoptotic signaling pathway#GO:0097193;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;signal transduction by p53 class mediator#GO:0072331;cellular response to stress#GO:0033554;regulation of transcription by RNA polymerase II#GO:0006357;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 P53-like transcription factor#PC00253;gene-specific transcriptional regulator#PC00264 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG184939|UniProtKB=T1FM68 T1FM68 20209917 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66728|UniProtKB=T1FYP6 T1FYP6 20213944 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165893|UniProtKB=T1EXE8 T1EXE8 20201248 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG176838|UniProtKB=T1FAY3 T1FAY3 20205982 PTHR46224:SF6 ANKYRIN REPEAT FAMILY PROTEIN IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG181851|UniProtKB=T1FHE3 T1FHE3 20208242 PTHR10340:SF34 SPHINGOMYELIN PHOSPHODIESTERASE SPHINGOMYELIN PHOSPHODIESTERASE hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569 phospholipid metabolic process#GO:0006644;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434;ceramide metabolic process#GO:0006672;biosynthetic process#GO:0009058;sphingomyelin metabolic process#GO:0006684;lipid biosynthetic process#GO:0008610;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148 lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG66963|UniProtKB=T1FYT9 T1FYT9 20213987 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG88642|UniProtKB=T1G747 T1G747 20216894 PTHR24115:SF1046 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF17 cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;axo-dendritic transport#GO:0008088;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG170509|UniProtKB=T1F353 T1F353 20203252 PTHR24026:SF133 FAT ATYPICAL CADHERIN-RELATED CADHERIN-RELATED FAMILY MEMBER 2 cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell adhesion#GO:0007155;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;anatomical structure development#GO:0048856;system development#GO:0048731;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502 cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG166696|UniProtKB=T1EYD7 T1EYD7 20201587 PTHR11599:SF6 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-2 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;proteasome complex#GO:0000502;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185580|UniProtKB=T1FN02 T1FN02 20210201 PTHR44313:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular component disassembly#GO:0022411;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;protein-containing complex disassembly#GO:0032984;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 chaperone#PC00072 HELRO|EnsemblGenome=HelroG86353|UniProtKB=T1G6B0 T1G6B0 20216607 PTHR11199:SF0 STROMAL ANTIGEN LD34181P-RELATED chromatin binding#GO:0003682;binding#GO:0005488 chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;cellular process#GO:0009987;cell cycle process#GO:0022402;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043 cohesin complex#GO:0008278;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG190500|UniProtKB=T1FS17 T1FS17 20211614 PTHR31395:SF26 SHISA GEO05642P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188082|UniProtKB=T1FPL8 T1FPL8 20210765 PTHR18934:SF91 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16 isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG192740|UniProtKB=T1FU90 T1FU90 20212386 PTHR10662:SF22 NUCLEAR RNA EXPORT FACTOR NUCLEAR RNA EXPORT FACTOR 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167586|UniProtKB=T1EZI8 T1EZI8 20201988 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG185550|UniProtKB=T1FMZ1 T1FMZ1 20210190 PTHR11711:SF479 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 1 purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;guanyl nucleotide binding#GO:0019001 localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf1#P00923 HELRO|EnsemblGenome=HelroG79615|UniProtKB=T1G3R0 T1G3R0 20215708 PTHR24343:SF348 SERINE/THREONINE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65501|UniProtKB=T1FY89 T1FY89 20213787 PTHR10527:SF3 IMPORTIN BETA TRANSPORTIN-1 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;protein localization to organelle#GO:0033365;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227 HELRO|EnsemblGenome=HelroG170439|UniProtKB=T1F326 T1F326 20203225 PTHR16238:SF7 GEM-ASSOCIATED PROTEIN 8 GEM-ASSOCIATED PROTEIN 8 protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal snRNP assembly#GO:0000387;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003 cytoplasm#GO:0005737;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;SMN complex#GO:0032797;protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG63393|UniProtKB=T1FXF2 T1FXF2 20213500 PTHR10117:SF80 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;channel activity#GO:0015267;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;binding#GO:0005488 cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;single fertilization#GO:0007338;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;regulation of cytosolic calcium ion concentration#GO:0051480;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;reproductive process#GO:0022414;fertilization#GO:0009566;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion homeostasis#GO:0098771;sexual reproduction#GO:0019953;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ion channel#PC00133 HELRO|EnsemblGenome=HelroG153507|UniProtKB=T1EL83 T1EL83 20197333 PTHR21454:SF31 DPH3 HOMOLOG-RELATED DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3 cation binding#GO:0043169;iron ion binding#GO:0005506;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155662|UniProtKB=T1ELK0 T1ELK0 20197450 PTHR10658:SF11 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN VIBRATOR, ISOFORM B transporter#PC00227 HELRO|EnsemblGenome=HelroG82350|UniProtKB=T1G4R0 T1G4R0 20216058 PTHR42884:SF38 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;proteolysis#GO:0006508;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;DPP signaling pathway#P06213>FUR1#P06290;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Activin beta signaling pathway#P06210>FUR1#P06238;DPP-SCW signaling pathway#P06212>FUR1#P06263;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;Endothelin signaling pathway#P00019>furin#P00575;MYO signaling pathway#P06215>FUR1#P06318;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG188369|UniProtKB=T1FPX5 T1FPX5 20210872 PTHR11534:SF9 MYOGENIC FACTOR MYOGENIC-DETERMINATION PROTEIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of developmental process#GO:0051094;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG96469|UniProtKB=T1G9C3 T1G9C3 20217670 PTHR11616:SF340 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;glycine transmembrane transporter activity#GO:0015187;metal ion transmembrane transporter activity#GO:0046873;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804 amino acid transport#GO:0006865;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;import into cell#GO:0098657;establishment of localization#GO:0051234;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;glycine transport#GO:0015816;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG98103|UniProtKB=T1G9K7 T1G9K7 20217753 PTHR31108:SF1 TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN ISOFORM X1 HELRO|EnsemblGenome=HelroG186161|UniProtKB=T1FNR0 T1FNR0 20210457 PTHR13403:SF6 SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1 SNURPORTIN-1 transporter#PC00227 HELRO|EnsemblGenome=HelroG155972|UniProtKB=T1ELQ2 T1ELQ2 20197502 PTHR46021:SF2 ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN CENTAURIN ALPHA phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;phosphatidylinositol phosphate binding#GO:1901981;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG179562|UniProtKB=T1FEV5 T1FEV5 20207354 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108199|UniProtKB=T1EEG7 T1EEG7 20194969 PTHR13254:SF0 GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7 RAS MODIFICATION PROTEIN ERF4 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150 protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG183412|UniProtKB=T1FJL4 T1FJL4 20209014 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79165|UniProtKB=T1G3L0 T1G3L0 20215658 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG184401|UniProtKB=T1FL46 T1FL46 20209545 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79413|UniProtKB=T1G3N6 T1G3N6 20215684 PTHR45810:SF9 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG103188|UniProtKB=T1EDE9 T1EDE9 20194601 PTHR20981:SF6 60S RIBOSOMAL PROTEIN L21 LARGE RIBOSOMAL SUBUNIT PROTEIN EL21 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG186127|UniProtKB=T1FNP7 T1FNP7 20210444 PTHR15327:SF0 MICROFIBRIL-ASSOCIATED PROTEIN MICROFIBRILLAR-ASSOCIATED PROTEIN 1 nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG185129|UniProtKB=T1FMF6 T1FMF6 20210005 PTHR23055:SF201 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG184267|UniProtKB=T1FKV8 T1FKV8 20209457 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191562|UniProtKB=T1FT31 T1FT31 20211978 PTHR46735:SF8 CALPAIN, SMALL SUBUNIT 1 A-RELATED CALPAIN-A-LIKE PROTEIN HELRO|EnsemblGenome=HelroG165415|UniProtKB=T1EWR2 T1EWR2 20201012 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122071|UniProtKB=T1EGT8 T1EGT8 20195788 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F-RELATED channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HELRO|EnsemblGenome=HelroG84726|UniProtKB=T1G5M7 T1G5M7 20216374 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG114213|UniProtKB=T1EG02 T1EG02 20195504 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119 carbohydrate transport#GO:0008643;cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;carbohydrate transmembrane transport#GO:0034219 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG170760|UniProtKB=T1F3E1 T1F3E1 20203340 PTHR21399:SF0 CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN METHYLOSOME SUBUNIT PICLN cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;cytosol#GO:0005829;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG191341|UniProtKB=T1FSW7 T1FSW7 20211914 PTHR21567:SF89 CLASP CLIP-ASSOCIATING PROTEIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 mitotic spindle organization#GO:0007052;establishment of organelle localization#GO:0051656;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cellular localization#GO:0051641;spindle localization#GO:0051653;nuclear division#GO:0000280;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;establishment of mitotic spindle localization#GO:0040001;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;organelle localization#GO:0051640;organelle assembly#GO:0070925;mitotic sister chromatid segregation#GO:0000070;mitotic spindle assembly#GO:0090307;establishment of spindle localization#GO:0051293;establishment of localization#GO:0051234;spindle organization#GO:0007051;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;spindle#GO:0005819;microtubule organizing center#GO:0005815;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;microtubule#GO:0005874;spindle microtubule#GO:0005876;intracellular organelle#GO:0043229;mitotic spindle#GO:0072686;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;kinetochore#GO:0000776;basal part of cell#GO:0045178;chromosome#GO:0005694;cytoplasmic microtubule#GO:0005881 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG182907|UniProtKB=T1FIX0 T1FIX0 20208769 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG194478|UniProtKB=T1FW36 T1FW36 20213032 PTHR23504:SF1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 GH21943P-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG174505|UniProtKB=T1F871 T1F871 20205020 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG114622|UniProtKB=T1EG35 T1EG35 20195537 PTHR10602:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 binding#GO:0005488;translation factor activity#GO:0180051;ribonucleoprotein complex binding#GO:0043021;translation initiation factor activity#GO:0003743;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904 translation factor#PC00223;translation initiation factor#PC00224 Apoptosis signaling pathway#P00006>ELF2alpha#P00307 HELRO|EnsemblGenome=HelroG69267|UniProtKB=T1FZS3 T1FZS3 20214321 PTHR24070:SF258 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAL-A hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 Ras Pathway#P04393>Ral#P04550 HELRO|EnsemblGenome=HelroG70877|UniProtKB=T1G0D4 T1G0D4 20214532 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HELRO|EnsemblGenome=HelroG102301|UniProtKB=T1ED93 T1ED93 20194545 PTHR12086:SF9 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 cilium or flagellum-dependent cell motility#GO:0001539;cytokinesis#GO:0000910;cilium-dependent cell motility#GO:0060285;cytoskeleton-dependent cytokinesis#GO:0061640;microtubule cytoskeleton organization#GO:0000226;cell division#GO:0051301;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;cell motility#GO:0048870;mitotic cytokinesis#GO:0000281;mitotic spindle organization#GO:0007052;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010 membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cell projection#GO:0042995;mitotic spindle#GO:0072686;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;cytoplasmic microtubule#GO:0005881;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;microtubule cytoskeleton#GO:0015630 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG144967|UniProtKB=T1EJH5 T1EJH5 20196881 PTHR11467:SF189 HISTONE H1 HISTONE 24 protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin DNA binding#GO:0031490 biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG184378|UniProtKB=T1FL32 T1FL32 20209531 PTHR47977:SF12 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-44 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 cellular process#GO:0009987;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG71833|UniProtKB=T1G0S1 T1G0S1 20214669 PTHR16517:SF162 TUBBY-RELATED PROTEIN KING TUBBY protein localization to cilium#GO:0061512;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;localization#GO:0051179;macromolecule localization#GO:0033036 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188679|UniProtKB=T1FQ88 T1FQ88 20210985 PTHR12618:SF20 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG189105|UniProtKB=T1FQN6 T1FQN6 20211133 PTHR21359:SF1 DUF5577 DOMAIN-CONTAINING PROTEIN DUF5577 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191579|UniProtKB=T1FT36 T1FT36 20211983 PTHR23277:SF108 NECTIN-RELATED FASCICLIN-3 binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell junction#GO:0030054 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG169948|UniProtKB=T1F2G8 T1F2G8 20203018 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG66368|UniProtKB=T1FYK3 T1FYK3 20213901 PTHR11972:SF206 NADPH OXIDASE NADPH OXIDASE 4 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;response to stress#GO:0006950;reactive oxygen species metabolic process#GO:0072593;defense response#GO:0006952;superoxide metabolic process#GO:0006801;response to stimulus#GO:0050896 catalytic complex#GO:1902494;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204 metabolite interconversion enzyme#PC00262;oxidase#PC00175 HELRO|EnsemblGenome=HelroG195129|UniProtKB=T1FWS3 T1FWS3 20213268 PTHR20886:SF11 VANG-LIKE PROTEIN VANG-LIKE PROTEIN signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;epithelium development#GO:0060429;tissue development#GO:0009888;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;morphogenesis of an epithelium#GO:0002009;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;non-canonical Wnt signaling pathway#GO:0035567;signaling#GO:0023052;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;tissue morphogenesis#GO:0048729;cell communication#GO:0007154;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG174006|UniProtKB=T1F7H0 T1F7H0 20204769 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67527|UniProtKB=T1FZ22 T1FZ22 20214070 PTHR10658:SF81 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN PROTEIN RETINAL DEGENERATION B lipid binding#GO:0008289;lipid transfer activity#GO:0120013;molecular carrier activity#GO:0140104;binding#GO:0005488;transporter activity#GO:0005215;cation binding#GO:0043169;intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;phosphatidylcholine intramembrane carrier activity#GO:0008525;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol transfer activity#GO:0008526;phosphatidylcholine binding#GO:0031210;phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG194585|UniProtKB=T1FW81 T1FW81 20213077 PTHR14058:SF8 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B PROTEIN FE65 HOMOLOG peptide binding#GO:0042277;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG159175|UniProtKB=T1ENP6 T1ENP6 20198196 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG67852|UniProtKB=T1FZ62 T1FZ62 20214110 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG78768|UniProtKB=T1G3F5 T1G3F5 20215603 PTHR24223:SF465 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG71540|UniProtKB=T1G0N0 T1G0N0 20214628 PTHR46176:SF1 LD21662P LD21662P HELRO|EnsemblGenome=HelroG111152|UniProtKB=T1EF88 T1EF88 20195240 PTHR16216:SF11 DYNEIN ASSEMBLY FACTOR 5, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 5 binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;organelle assembly#GO:0070925;inner dynein arm assembly#GO:0036159;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG175057|UniProtKB=T1F8S7 T1F8S7 20205226 PTHR10131:SF153 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77129|UniProtKB=T1G2T4 T1G2T4 20215382 PTHR12778:SF9 SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED ACETYL-COENZYME A TRANSPORTER 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG85597|UniProtKB=T1G603 T1G603 20216500 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;bicarbonate transmembrane transporter activity#GO:0015106;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;biological regulation#GO:0065007;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG183655|UniProtKB=T1FK01 T1FK01 20209150 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG169960|UniProtKB=T1F2H3 T1F2H3 20203023 PTHR19282:SF516 TETRASPANIN LEUKOCYTE ANTIGEN CD37 ISOFORM X1 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185844|UniProtKB=T1FND0 T1FND0 20210327 PTHR45827:SF1 SORTING NEXIN SORTING NEXIN ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 cellular component organization#GO:0016043;endocytosis#GO:0006897;cellular localization#GO:0051641;localization#GO:0051179;plasma membrane organization#GO:0007009;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;endosomal transport#GO:0016197 cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161283|UniProtKB=T1ERA4 T1ERA4 20199104 PTHR23185:SF0 PROTEIN VIRILIZER HOMOLOG PROTEIN VIRILIZER HOMOLOG catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180976|UniProtKB=T1FGH3 T1FGH3 20207922 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG109931|UniProtKB=T1EEX4 T1EEX4 20195126 PTHR12608:SF1 TRANSMEMBRANE PROTEIN HTP-1 RELATED DIVALENT CATION_PROTON ANTIPORTER TMEM165-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG154236|UniProtKB=T1ELE1 T1ELE1 20197391 PTHR11079:SF156 CYTOSINE DEAMINASE FAMILY MEMBER TRNA-SPECIFIC ADENOSINE-34 DEAMINASE REGULATORY SUBUNIT ADAT3 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;deaminase#PC00088;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194656|UniProtKB=T1FWA2 T1FWA2 20213098 PTHR11079:SF208 CYTOSINE DEAMINASE FAMILY MEMBER TRNA-SPECIFIC ADENOSINE-34 DEAMINASE CATALYTIC SUBUNIT ADAT2 hydrolase activity#GO:0016787;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;tRNA-specific adenosine deaminase activity#GO:0008251;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble base modification#GO:0002097;adenosine to inosine editing#GO:0006382;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;base conversion or substitution editing#GO:0016553;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121;deaminase#PC00088;metabolite interconversion enzyme#PC00262 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCTP deaminase#P02920;Salvage pyrimidine ribonucleotides#P02775>Cytosine deaminase#P03155;Salvage pyrimidine deoxyribonucleotides#P02774>Cytidine deaminase#P03144;Salvage pyrimidine ribonucleotides#P02775>Cytidine deaminase#P03154 HELRO|EnsemblGenome=HelroG194108|UniProtKB=T1FVP4 T1FVP4 20212890 PTHR13115:SF8 RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428 HELRO|EnsemblGenome=HelroG122790|UniProtKB=T1EGV9 T1EGV9 20195809 PTHR10656:SF70 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-LIKE transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG160107|UniProtKB=T1EPT0 T1EPT0 20198580 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG191359|UniProtKB=T1FSX2 T1FSX2 20211919 PTHR46116:SF51 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity#GO:0003824;transferase activity#GO:0016740 vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG158944|UniProtKB=T1ENF4 T1ENF4 20198104 PTHR13245:SF14 RRP15-LIKE PROTEIN RRP15-LIKE PROTEIN macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HELRO|EnsemblGenome=HelroG182845|UniProtKB=T1FIU7 T1FIU7 20208746 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75940|UniProtKB=T1G2D0 T1G2D0 20215228 PTHR23402:SF1 PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED RE07960P peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG165414|UniProtKB=T1EWR1 T1EWR1 20201011 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG80150|UniProtKB=T1G3Y3 T1G3Y3 20215781 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193526|UniProtKB=T1FV30 T1FV30 20212676 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG163337|UniProtKB=T1ETX6 T1ETX6 20200026 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG67096|UniProtKB=T1FYW2 T1FYW2 20214010 PTHR21328:SF2 POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP16 molecular function activator activity#GO:0140677;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;kinase activator activity#GO:0019209;kinase binding#GO:0019900;binding#GO:0005488;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;nucleus#GO:0005634;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG62468|UniProtKB=T1FX12 T1FX12 20213360 PTHR10106:SF0 CYTOCHROME B561-RELATED LD36721P oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG90077|UniProtKB=T1G7K9 T1G7K9 20217056 PTHR44085:SF2 SEPIAPTERIN REDUCTASE SEPIAPTERIN REDUCTASE oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 reductase#PC00198 HELRO|EnsemblGenome=HelroG167969|UniProtKB=T1F007 T1F007 20202157 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 32 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TLR#P01346 HELRO|EnsemblGenome=HelroG84905|UniProtKB=T1G5Q2 T1G5Q2 20216399 PTHR11829:SF416 FORKHEAD BOX PROTEIN FORKHEAD DOMAIN 102C sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG85437|UniProtKB=T1G5X1 T1G5X1 20216468 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG173823|UniProtKB=T1F7A2 T1F7A2 20204701 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG101326|UniProtKB=T1ED39 T1ED39 20194492 PTHR12755:SF6 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;mRNA polyadenylation factor#PC00146;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG169144|UniProtKB=T1F1G7 T1F1G7 20202667 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165458|UniProtKB=T1EWU1 T1EWU1 20201041 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113366|UniProtKB=T1EFR8 T1EFR8 20195420 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER LD05335P monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915 transition metal ion transport#GO:0000041;transport#GO:0006810;zinc ion transmembrane transport#GO:0071577;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG173822|UniProtKB=T1F7A1 T1F7A1 20204700 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG66826|UniProtKB=T1FYR7 T1FYR7 20213965 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 transferase#PC00220 HELRO|EnsemblGenome=HelroG72262|UniProtKB=T1G0X6 T1G0X6 20214724 PTHR13082:SF0 SAP18 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 Hedgehog signaling pathway#P00025>Sap18#P00697 HELRO|EnsemblGenome=HelroG166405|UniProtKB=T1EY35 T1EY35 20201485 PTHR12210:SF202 DULLARD PROTEIN PHOSPHATASE PHOSPHATASE HERZOG phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG185219|UniProtKB=T1FMI7 T1FMI7 20210036 PTHR23050:SF552 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;molecular function regulator activity#GO:0098772 cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;T cell activation#P00053>Calmodulin#P01305;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG178835|UniProtKB=T1FDT3 T1FDT3 20206982 PTHR10590:SF24 SODIUM/NUCLEOSIDE COTRANSPORTER CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1-RELATED solute:sodium symporter activity#GO:0015370;nucleobase-containing compound transmembrane transporter activity#GO:0015932;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate derivative transmembrane transporter activity#GO:1901505;symporter activity#GO:0015293;solute:monoatomic cation symporter activity#GO:0015294;nucleoside transmembrane transporter activity#GO:0005337;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG100213|UniProtKB=T1ECY9 T1ECY9 20194441 PTHR24056:SF597 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 12 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of cellular process#GO:0050794;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG87051|UniProtKB=T1G6L1 T1G6L1 20216708 PTHR45746:SF6 LP21163P LP21163P nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG136534|UniProtKB=T1EIE4 T1EIE4 20196344 PTHR23349:SF68 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FI14601P transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG145048|UniProtKB=T1EJI2 T1EJI2 20196732 PTHR10071:SF340 TRANSCRIPTION FACTOR GATA FAMILY MEMBER FI19405P1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;cell fate commitment#GO:0045165;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185628|UniProtKB=T1FN23 T1FN23 20210222 PTHR43920:SF11 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL CLIC monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;transport#GO:0006810 apical part of cell#GO:0045177;intracellular anatomical structure#GO:0005622;apical plasma membrane#GO:0016324;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG103959|UniProtKB=T1EDI8 T1EDI8 20194640 PTHR11035:SF35 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;oxoacid metabolic process#GO:0043436 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 dehydratase#PC00091 HELRO|EnsemblGenome=HelroG183528|UniProtKB=T1FJS8 T1FJS8 20209077 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191088|UniProtKB=T1FSK8 T1FSK8 20211805 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG169168|UniProtKB=T1F1I6 T1F1I6 20202686 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186784|UniProtKB=T1FP35 T1FP35 20210582 PTHR13317:SF5 TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;regulation of cell projection assembly#GO:0060491;positive regulation of organelle organization#GO:0010638;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;positive regulation of cellular component biogenesis#GO:0044089;regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035 membraneless organelle#GO:0043228;organelle membrane#GO:0031090;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;cilium#GO:0005929;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG64794|UniProtKB=T1FXZ4 T1FXZ4 20213692 PTHR24033:SF218 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162315|UniProtKB=T1ESI1 T1ESI1 20199531 PTHR21844:SF2 AKT1 SUBSTRATE 1 PROTEIN PROLINE-RICH AKT1 SUBSTRATE 1 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of TOR signaling#GO:0032006;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;negative regulation of TORC1 signaling#GO:1904262;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 CCKR signaling map#P06959>PRAS40#P07076 HELRO|EnsemblGenome=HelroG96551|UniProtKB=T1G9C8 T1G9C8 20217675 PTHR12558:SF10 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 23 HOMOLOG enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of chromosome organization#GO:0033044;regulation of mitotic sister chromatid separation#GO:0010965;macromolecule metabolic process#GO:0043170;positive regulation of mitotic cell cycle#GO:0045931;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of nuclear division#GO:0051783;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;cell division#GO:0051301;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;positive regulation of mitotic nuclear division#GO:0045840;regulation of chromosome segregation#GO:0051983;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of chromosome separation#GO:1905818;positive regulation of cell cycle#GO:0045787;proteasomal protein catabolic process#GO:0010498;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;regulation of cellular component organization#GO:0051128;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726 nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG125085|UniProtKB=T1EH42 T1EH42 20195892 PTHR21183:SF18 RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;metabolic process#GO:0008152;translation#GO:0006412 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185515|UniProtKB=T1FMX2 T1FMX2 20210171 PTHR14186:SF27 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG155673|UniProtKB=T1ELK3 T1ELK3 20197453 PTHR46012:SF2 IP22168P UDP-D-XYLOSE:BETA-D-GLUCOSIDE ALPHA-1,3-D-XYLOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;UDP-xylosyltransferase activity#GO:0035252;pentosyltransferase activity#GO:0016763;UDP-glycosyltransferase activity#GO:0008194;xylosyltransferase activity#GO:0042285;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 HELRO|EnsemblGenome=HelroG194341|UniProtKB=T1FVY4 T1FVY4 20212980 PTHR10417:SF15 GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11 ISOFORM X1 HELRO|EnsemblGenome=HelroG95427|UniProtKB=T1G959 T1G959 20217606 PTHR45626:SF50 TRANSCRIPTION TERMINATION FACTOR 2-RELATED TRANSCRIPTION TERMINATION FACTOR 2 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity#GO:0140657 DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389 HELRO|EnsemblGenome=HelroG75154|UniProtKB=T1G216 T1G216 20215114 PTHR10655:SF74 LYSOPHOSPHOLIPASE-RELATED LYSOPHOSPHOLIPASE-LIKE PROTEIN 1 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;thiolester hydrolase activity#GO:0016790;palmitoyl hydrolase activity#GO:0098599;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 negative regulation of cellular process#GO:0048523;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;regulation of transport#GO:0051049;regulation of localization#GO:0032879;negative regulation of biological process#GO:0048519;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;negative regulation of transport#GO:0051051;biological regulation#GO:0065007;negative regulation of protein transport#GO:0051224 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG75027|UniProtKB=T1G1Z5 T1G1Z5 20215093 PTHR45620:SF44 PDF RECEPTOR-LIKE PROTEIN-RELATED G-PROTEIN COUPLED RECEPTOR, ORPHAN-RELATED G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG111417|UniProtKB=T1EFB2 T1EFB2 20195264 PTHR43580:SF10 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA biosynthetic process#GO:0032774;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;chromatin organization#GO:0006325 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG109971|UniProtKB=T1EEX9 T1EEX9 20195131 PTHR48099:SF11 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;oxidoreductase activity#GO:0016491;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824 tetrahydrofolate biosynthetic process#GO:0046654;metabolic process#GO:0008152;tetrahydrofolate metabolic process#GO:0046653;cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;biosynthetic process#GO:0009058;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HELRO|EnsemblGenome=HelroG175169|UniProtKB=T1F8Y5 T1F8Y5 20205284 PTHR10807:SF110 MYOTUBULARIN-RELATED FI17948P1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 dephosphorylation#GO:0016311;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG71005|UniProtKB=T1G0F5 T1G0F5 20214553 PTHR11183:SF204 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN GLUCOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251;catalytic activity#GO:0003824;transferase activity#GO:0016740;glucosyltransferase activity#GO:0046527;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG171072|UniProtKB=T1F3S3 T1F3S3 20203472 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186 HELRO|EnsemblGenome=HelroG160625|UniProtKB=T1EQI4 T1EQI4 20198834 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to starvation#GO:0042594;response to stress#GO:0006950 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG172300|UniProtKB=T1F570 T1F570 20203969 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154346|UniProtKB=T1ELE5 T1ELE5 20197395 PTHR11889:SF86 HEDGEHOG PROTEIN HEDGEHOG cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;signaling receptor binding#GO:0005102;small molecule binding#GO:0036094 cell communication#GO:0007154;smoothened signaling pathway#GO:0007224;cell fate commitment#GO:0045165;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;signaling#GO:0023052;cell fate specification#GO:0001708;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Hedgehog signaling pathway#P00025>Hedgehog#P00688 HELRO|EnsemblGenome=HelroG167917|UniProtKB=T1EZY5 T1EZY5 20202135 PTHR47577:SF1 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG190561|UniProtKB=T1FS33 T1FS33 20211630 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;positive regulation of actin filament bundle assembly#GO:0032233;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component organization#GO:0051130;actin filament-based process#GO:0030029;positive regulation of organelle organization#GO:0010638;supramolecular fiber organization#GO:0097435;regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG117205|UniProtKB=T1EGL1 T1EGL1 20195711 PTHR24185:SF10 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;A2-type glycerophospholipase activity#GO:0004623;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 olefinic compound metabolic process#GO:0120254;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;arachidonate metabolic process#GO:0019369;icosanoid metabolic process#GO:0006690;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;membrane#GO:0016020 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG182161|UniProtKB=T1FHU7 T1FHU7 20208396 PTHR15600:SF42 SACSIN SACSIN_NOV DOMAIN-CONTAINING PROTEIN Hsp70 protein binding#GO:0030544;protein binding#GO:0005515;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 HELRO|EnsemblGenome=HelroG193690|UniProtKB=T1FV94 T1FV94 20212740 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789 membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177495|UniProtKB=T1FBS7 T1FBS7 20206276 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66664|UniProtKB=T1FYN6 T1FYN6 20213934 PTHR10766:SF188 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4 macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;localization within membrane#GO:0051668;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG167262|UniProtKB=T1EZ68 T1EZ68 20201868 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186274|UniProtKB=T1FNW4 T1FNW4 20210511 PTHR43995:SF1 PRE-MRNA-PROCESSING FACTOR 19 PRE-MRNA-PROCESSING FACTOR 19 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA processing factor#PC00147;RNA metabolism protein#PC00031 mRNA splicing#P00058>U4#P01476 HELRO|EnsemblGenome=HelroG194347|UniProtKB=T1FVY7 T1FVY7 20212983 PTHR11360:SF286 MONOCARBOXYLATE TRANSPORTER GH22266P-RELATED monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215 establishment of localization#GO:0051234;localization#GO:0051179;monocarboxylic acid transport#GO:0015718;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG80076|UniProtKB=T1G3X4 T1G3X4 20215772 PTHR19957:SF307 SYNTAXIN SYNTAXIN-1A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 localization#GO:0051179;cellular localization#GO:0051641;secretion#GO:0046903;secretion by cell#GO:0032940;protein transport#GO:0015031;export from cell#GO:0140352;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;exocytosis#GO:0006887;vesicle organization#GO:0016050;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane fusion#GO:0061025;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;cytoplasm#GO:0005737;plasma membrane#GO:0005886 SNARE protein#PC00034 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066 HELRO|EnsemblGenome=HelroG184395|UniProtKB=T1FL43 T1FL43 20209542 PTHR46169:SF30 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4 ISOFORM X1 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG191177|UniProtKB=T1FSP7 T1FSP7 20211844 PTHR10316:SF40 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED LD27118P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell communication#GO:0007154;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of protein localization to membrane#GO:1905475;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cell-cell junction#GO:0005911;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cell junction#GO:0030054;adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182651|UniProtKB=T1FIJ4 T1FIJ4 20208643 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription regulatory region nucleic acid binding#GO:0001067;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG157540|UniProtKB=T1EMC9 T1EMC9 20197729 PTHR46126:SF1 DYNACTIN SUBUNIT 5 DYNACTIN SUBUNIT 5 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG193922|UniProtKB=T1FVH3 T1FVH3 20212819 PTHR13544:SF0 SELENOPROTEIN T THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T disulfide oxidoreductase activity#GO:0015036;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;antioxidant activity#GO:0016209;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG108240|UniProtKB=T1EEH6 T1EEH6 20194978 PTHR11537:SF289 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 action potential#GO:0001508;metal ion transport#GO:0030001;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG168937|UniProtKB=T1F158 T1F158 20202558 PTHR13802:SF52 MUCIN 4-RELATED NIDOGEN-RELATED membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG78375|UniProtKB=T1G3B1 T1G3B1 20215559 PTHR12906:SF0 PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN GEL COMPLEX SUBUNIT OPTI HELRO|EnsemblGenome=HelroG184108|UniProtKB=T1FKL4 T1FKL4 20209363 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG181244|UniProtKB=T1FGS4 T1FGS4 20208023 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172592|UniProtKB=T1F5K6 T1F5K6 20204105 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85143|UniProtKB=T1G5T3 T1G5T3 20216430 PTHR11977:SF130 VILLIN SEVERIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 regulation of actin filament length#GO:0030832;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of actin filament depolymerization#GO:0030834;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG75143|UniProtKB=T1G213 T1G213 20215111 PTHR24412:SF135 KELCH PROTEIN KELCH-LIKE PROTEIN 5 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160181|UniProtKB=T1EPX7 T1EPX7 20198627 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92225|UniProtKB=T1G8D2 T1G8D2 20217329 PTHR19850:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494 protein-binding activity modulator#PC00095;G-protein#PC00020;heterotrimeric G-protein#PC00117 Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;PI3 kinase pathway#P00048>Gbetagamma#P01188;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458 HELRO|EnsemblGenome=HelroG188500|UniProtKB=T1FQ21 T1FQ21 20210918 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;cell fate commitment#GO:0045165;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell fate specification#GO:0001708;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of cellular process#GO:0048522;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;neuron fate commitment#GO:0048663;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG171303|UniProtKB=T1F424 T1F424 20203573 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG186261|UniProtKB=T1FNV9 T1FNV9 20210506 PTHR43170:SF5 GMP REDUCTASE GMP REDUCTASE reductase#PC00198;oxidoreductase#PC00176 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HELRO|EnsemblGenome=HelroG75635|UniProtKB=T1G280 T1G280 20215178 PTHR24092:SF190 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;ATPase-coupled intramembrane lipid carrier activity#GO:0140326 lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;phospholipid transport#GO:0015914;lipid transport#GO:0006869 cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG70057|UniProtKB=T1G019 T1G019 20214417 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG77906|UniProtKB=T1G353 T1G353 20215501 PTHR16110:SF1 TBC1 DOMAIN FAMILY MEMBER 19 TBC1 DOMAIN FAMILY MEMBER 19 HELRO|EnsemblGenome=HelroG62194|UniProtKB=T1FWW8 T1FWW8 20213316 PTHR23147:SF68 SERINE/ARGININE RICH SPLICING FACTOR SPLICING FACTOR, ARGININE_SERINE-RICH 2-RELATED intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79507|UniProtKB=T1G3P5 T1G3P5 20215693 PTHR48092:SF9 KNIRPS-RELATED PROTEIN-RELATED KNIRPS-RELATED PROTEIN-RELATED DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG167589|UniProtKB=T1EZI9 T1EZI9 20201989 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185774|UniProtKB=T1FN99 T1FN99 20210297 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Cell cycle#P00013>Protein kinase subunit#P00482;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035 HELRO|EnsemblGenome=HelroG158879|UniProtKB=T1END0 T1END0 20198080 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG183791|UniProtKB=T1FK71 T1FK71 20209220 PTHR10417:SF15 GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11 ISOFORM X1 HELRO|EnsemblGenome=HelroG161106|UniProtKB=T1ER37 T1ER37 20199037 PTHR23050:SF547 CALCIUM BINDING PROTEIN AT10229P-RELATED calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG158226|UniProtKB=T1EMK8 T1EMK8 20197808 PTHR23043:SF36 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PROTEIN SINGLE-MINDED nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185203|UniProtKB=T1FMI1 T1FMI1 20210030 PTHR46568:SF1 ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG69833|UniProtKB=T1FZY8 T1FZY8 20214386 PTHR24543:SF325 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164985|UniProtKB=T1EW25 T1EW25 20200775 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG172266|UniProtKB=T1F561 T1F561 20203960 PTHR15439:SF22 RETINOBLASTOMA-BINDING PROTEIN 6 DNA LIGASE (NAD(+)) ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65991|UniProtKB=T1FYF7 T1FYF7 20213855 PTHR31247:SF5 TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER TRANSMEMBRANE PROTEIN 198 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG91627|UniProtKB=T1G866 T1G866 20217263 PTHR10768:SF0 60S RIBOSOMAL PROTEIN L37 RIBOSOMAL PROTEIN L37 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG164917|UniProtKB=T1EVZ1 T1EVZ1 20200741 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L, LIKE-RELATED peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189921|UniProtKB=T1FRH8 T1FRH8 20211425 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194375|UniProtKB=T1FVZ9 T1FVZ9 20212995 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG194133|UniProtKB=T1FVQ5 T1FVQ5 20212901 PTHR13859:SF11 ATROPHIN-RELATED GRUNGE, ISOFORM J transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG176453|UniProtKB=T1FAI7 T1FAI7 20205836 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG64935|UniProtKB=T1FY15 T1FY15 20213713 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network membrane#GO:0032588;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG96941|UniProtKB=T1G9E5 T1G9E5 20217692 PTHR11807:SF12 ATPASES OF THE PP SUPERFAMILY-RELATED CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;tRNA binding#GO:0000049 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;tRNA thio-modification#GO:0034227;macromolecule modification#GO:0043412;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;tRNA wobble position uridine thiolation#GO:0002143;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;sulfurtransferase complex#GO:1990228;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG156238|UniProtKB=T1ELT2 T1ELT2 20197532 PTHR23050:SF552 CALCIUM BINDING PROTEIN AT16150P-RELATED enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;molecular function regulator activity#GO:0098772 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 calcium-binding protein#PC00060;calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;T cell activation#P00053>Calmodulin#P01305;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG164616|UniProtKB=T1EVN1 T1EVN1 20200631 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG66482|UniProtKB=T1FYL9 T1FYL9 20213917 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108 monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG107894|UniProtKB=T1EED7 T1EED7 20194939 PTHR47992:SF257 PROTEIN PHOSPHATASE ALPHABET, ISOFORM E phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of response to stimulus#GO:0048585;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 DPP signaling pathway#P06213>PPM1A#P06289;Activin beta signaling pathway#P06210>PPM1A#P06237;MYO signaling pathway#P06215>PPM1A#P06317;SCW signaling pathway#P06216>PPM1A#P06332;BMP/activin signaling pathway-drosophila#P06211>PPM1A#P06247;GBB signaling pathway#P06214>PPM1A#P06296;ALP23B signaling pathway#P06209>PPM1A#P06226;DPP-SCW signaling pathway#P06212>PPM1A#P06261 HELRO|EnsemblGenome=HelroG182898|UniProtKB=T1FIW7 T1FIW7 20208766 PTHR31336:SF3 LIN37 HOMOLOG PROTEIN LIN-37 HOMOLOG regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG73874|UniProtKB=T1G1J8 T1G1J8 20214946 PTHR10055:SF1 TRYPTOPHANYL-TRNA SYNTHETASE TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG62837|UniProtKB=T1FX57 T1FX57 20213405 PTHR12357:SF140 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN RNA binding#GO:0003723;protein-RNA adaptor activity#GO:0140517;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179748|UniProtKB=T1FF42 T1FF42 20207441 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG179440|UniProtKB=T1FEP9 T1FEP9 20207298 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG106545|UniProtKB=T1EE33 T1EE33 20194835 PTHR11599:SF11 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 proteasome complex#GO:0000502;nucleus#GO:0005634;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG160011|UniProtKB=T1EPN5 T1EPN5 20198535 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177268|UniProtKB=T1FBF6 T1FBF6 20206155 PTHR14454:SF11 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER SERRANO, ISOFORM F HELRO|EnsemblGenome=HelroG170399|UniProtKB=T1F304 T1F304 20203203 PTHR13989:SF16 REPLICATION PROTEIN A-RELATED REPLICATION FACTOR A PROTEIN 2 DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 nucleus#GO:0005634;site of double-strand break#GO:0035861;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;chromosome, telomeric region#GO:0000781;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;replisome#GO:0030894;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622 DNA replication#P00017>RPA#P00537 HELRO|EnsemblGenome=HelroG81553|UniProtKB=T1G4F8 T1G4F8 20215956 PTHR20933:SF4 F-BOX ONLY PROTEIN 33 F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A HELRO|EnsemblGenome=HelroG156879|UniProtKB=T1EM25 T1EM25 20197625 PTHR43128:SF34 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;monocarboxylic acid catabolic process#GO:0072329;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG101766|UniProtKB=T1ED69 T1ED69 20194521 PTHR15948:SF8 G-PROTEIN COUPLED RECEPTOR 89-RELATED GOLGI PH REGULATOR A-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic anion channel activity#GO:0008308;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832 regulation of biological quality#GO:0065008;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;regulation of pH#GO:0006885;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;regulation of intracellular pH#GO:0051453;homeostatic process#GO:0042592;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG194337|UniProtKB=T1FVY2 T1FVY2 20212978 PTHR12751:SF18 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 2 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG158884|UniProtKB=T1END4 T1END4 20198084 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG146672|UniProtKB=T1EJT7 T1EJT7 20196837 PTHR11829:SF388 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN CROCODILE RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG185770|UniProtKB=T1FN97 T1FN97 20210295 PTHR46367:SF1 ATAXIN-7-LIKE PROTEIN 3 ATAXIN-7-LIKE PROTEIN 3 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;SAGA-type complex#GO:0070461;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;DUBm complex#GO:0071819;SAGA complex#GO:0000124;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG175354|UniProtKB=T1F966 T1F966 20205365 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163616|UniProtKB=T1EUA2 T1EUA2 20200152 PTHR24365:SF530 TOLL-LIKE RECEPTOR TOLL-9, ISOFORM A molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181885|UniProtKB=T1FHF4 T1FHF4 20208253 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG114917|UniProtKB=T1EG54 T1EG54 20195556 PTHR12203:SF122 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG174071|UniProtKB=T1F7K0 T1F7K0 20204799 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG189698|UniProtKB=T1FR98 T1FR98 20211345 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193072|UniProtKB=T1FUL5 T1FUL5 20212511 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG182210|UniProtKB=T1FHX6 T1FHX6 20208425 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163242|UniProtKB=T1ETT9 T1ETT9 20199989 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155593|UniProtKB=T1ELJ4 T1ELJ4 20197444 PTHR24056:SF598 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell cycle#GO:0007049;signaling#GO:0023052;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;mitotic cell cycle phase transition#GO:0044772;cell communication#GO:0007154;cellular process#GO:0009987;cell cycle G2/M phase transition#GO:0044839;signal transduction#GO:0007165;biological regulation#GO:0065007;mitotic cell cycle process#GO:1903047 serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625;p53 pathway#P00059>Cdc2#P04634 HELRO|EnsemblGenome=HelroG180729|UniProtKB=T1FG77 T1FG77 20207826 PTHR13283:SF14 KREV INTERACTION TRAPPED 1-RELATED FERM DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 anatomical structure development#GO:0048856;anterior/posterior axis specification#GO:0009948;multicellular organism development#GO:0007275;cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;pattern specification process#GO:0007389;regulation of establishment or maintenance of cell polarity#GO:0032878;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regionalization#GO:0003002;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81825|UniProtKB=T1G4J2 T1G4J2 20215990 PTHR46052:SF1 PHOSDUCIN-LIKE PROTEIN PHOSDUCIN-LIKE PROTEIN 1 HELRO|EnsemblGenome=HelroG159462|UniProtKB=T1EP23 T1EP23 20198323 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG193941|UniProtKB=T1FVI1 T1FVI1 20212827 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578 purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG64273|UniProtKB=T1FXS2 T1FXS2 20213620 PTHR24031:SF594 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX52-RELATED cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG78021|UniProtKB=T1G368 T1G368 20215516 PTHR44216:SF3 PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178791|UniProtKB=T1FDR0 T1FDR0 20206959 PTHR24261:SF17 PLASMINOGEN-RELATED KRINGLE DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190754|UniProtKB=T1FS96 T1FS96 20211693 PTHR39490:SF13 ARRESTIN DOMAIN-CONTAINING PROTEIN D FYVE-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182328|UniProtKB=T1FI26 T1FI26 20208475 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184635|UniProtKB=T1FLM8 T1FLM8 20209727 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG172606|UniProtKB=T1F5L9 T1F5L9 20204118 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172439|UniProtKB=T1F5C0 T1F5C0 20204019 PTHR24324:SF5 HOMEOBOX PROTEIN HHEX HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG164946|UniProtKB=T1EW01 T1EW01 20200751 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP-TYPE DOMAIN-CONTAINING PROTEIN zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG194199|UniProtKB=T1FVS6 T1FVS6 20212922 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG178024|UniProtKB=T1FCM3 T1FCM3 20206572 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG76832|UniProtKB=T1G2P9 T1G2P9 20215347 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG64539|UniProtKB=T1FXW1 T1FXW1 20213659 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;sodium ion transmembrane transporter activity#GO:0015081;voltage-gated sodium channel activity#GO:0005248;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;system process#GO:0003008;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;action potential#GO:0001508;sodium ion transport#GO:0006814;sensory perception of pain#GO:0019233;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;sensory perception#GO:0007600;nervous system process#GO:0050877 cation channel complex#GO:0034703;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG83426|UniProtKB=T1G553 T1G553 20216201 PTHR24333:SF17 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX PROTEIN UNPLUGGED-RELATED homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG173611|UniProtKB=T1F717 T1F717 20204616 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HELRO|EnsemblGenome=HelroG189312|UniProtKB=T1FQY1 T1FQY1 20211228 PTHR13388:SF11 DETONATOR, ISOFORM E DETONATOR, ISOFORM E cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG182588|UniProtKB=T1FIF1 T1FIF1 20208600 PTHR22802:SF396 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023;binding#GO:0005488 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185752|UniProtKB=T1FN89 T1FN89 20210287 PTHR18968:SF166 THIAMINE PYROPHOSPHATE ENZYMES 2-HYDROXYACYL-COA LYASE 2 flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;catalytic activity#GO:0003824;transferase activity#GO:0016740;transketolase or transaldolase activity#GO:0016744;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;branched-chain amino acid biosynthetic process#GO:0009082;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;ligase#PC00142 Valine biosynthesis#P02785>Acetolactate synthase#P03216;Isoleucine biosynthesis#P02748>Acetolactate synthase#P02997 HELRO|EnsemblGenome=HelroG173596|UniProtKB=T1F702 T1F702 20204601 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197 cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768 HELRO|EnsemblGenome=HelroG184972|UniProtKB=T1FM79 T1FM79 20209928 PTHR23222:SF0 PROHIBITIN PROHIBITIN 1 HELRO|EnsemblGenome=HelroG174298|UniProtKB=T1F7Y6 T1F7Y6 20204935 PTHR46670:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84990|UniProtKB=T1G5R2 T1G5R2 20216409 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG75097|UniProtKB=T1G205 T1G205 20215103 PTHR10715:SF0 60S RIBOSOMAL PROTEIN L6 LARGE RIBOSOMAL SUBUNIT PROTEIN EL6 RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181 cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG189216|UniProtKB=T1FQT1 T1FQT1 20211178 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH19970P-RELATED active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293 monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;transport#GO:0006810;sodium ion transport#GO:0006814 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG63741|UniProtKB=T1FXJ5 T1FXJ5 20213543 PTHR45832:SF8 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG69428|UniProtKB=T1FZV3 T1FZV3 20214351 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG194106|UniProtKB=T1FVP3 T1FVP3 20212889 PTHR45734:SF10 TENSIN BLISTERY, ISOFORM A cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG164546|UniProtKB=T1EVK3 T1EVK3 20200603 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164373|UniProtKB=T1EVC1 T1EVC1 20200521 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG88724|UniProtKB=T1G758 T1G758 20216905 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180154|UniProtKB=T1FFJ1 T1FFJ1 20207590 PTHR46518:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 151 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG116577|UniProtKB=T1EGG2 T1EGG2 20195664 PTHR10185:SF17 PHOSPHOLIPASE D - RELATED GM01519P-RELATED phospholipase#PC00186 HELRO|EnsemblGenome=HelroG193701|UniProtKB=T1FVA0 T1FVA0 20212746 PTHR11036:SF127 SEMAPHORIN SEMAPHORIN-1A binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;taxis#GO:0042330;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;locomotion#GO:0040011;chemotaxis#GO:0006935;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;system development#GO:0048731 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG159530|UniProtKB=T1EP50 T1EP50 20198350 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113207|UniProtKB=T1EFQ8 T1EFQ8 20195410 PTHR43205:SF7 PROSTAGLANDIN REDUCTASE PROSTAGLANDIN REDUCTASE 1-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 reductase#PC00198 HELRO|EnsemblGenome=HelroG190766|UniProtKB=T1FSA0 T1FSA0 20211697 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG62728|UniProtKB=T1FX42 T1FX42 20213390 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of primary metabolic process#GO:0080090;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;sensory organ development#GO:0007423;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG177237|UniProtKB=T1FBE1 T1FBE1 20206140 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184060|UniProtKB=T1FKI3 T1FKI3 20209332 PTHR47027:SF30 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179602|UniProtKB=T1FEX6 T1FEX6 20207375 PTHR12675:SF12 MUSCLEBLIND-LIKE PROTEIN PROTEIN MUSCLEBLIND RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG186257|UniProtKB=T1FNV7 T1FNV7 20210504 PTHR10803:SF3 ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE ATPASE GET3 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111 protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG178667|UniProtKB=T1FDJ2 T1FDJ2 20206891 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70064|UniProtKB=T1G021 T1G021 20214419 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG194715|UniProtKB=T1FWC3 T1FWC3 20213118 PTHR10697:SF13 MAMMALIAN EPENDYMIN-RELATED PROTEIN 1 RICIN B LECTIN DOMAIN-CONTAINING PROTEIN vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG89696|UniProtKB=T1G7G1 T1G7G1 20217008 PTHR48013:SF11 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 FGF signaling pathway#P00021>MKK3,6#P00625;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891;EGF receptor signaling pathway#P00018>MKK3,6#P00540;Huntington disease#P00029>SEK-1#P00792 HELRO|EnsemblGenome=HelroG163831|UniProtKB=T1EUI7 T1EUI7 20200237 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG82406|UniProtKB=T1G4R9 T1G4R9 20216067 PTHR12225:SF0 ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN PROTEASOMAL UBIQUITIN RECEPTOR ADRM1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 proteasome complex#GO:0000502;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;proteasome regulatory particle, lid subcomplex#GO:0008541;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG104849|UniProtKB=T1EDN8 T1EDN8 20194690 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG176860|UniProtKB=T1FAZ7 T1FAZ7 20205996 PTHR10438:SF468 THIOREDOXIN THIOREDOXIN-1 protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG83563|UniProtKB=T1G573 T1G573 20216221 PTHR20934:SF0 TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899 RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG125265|UniProtKB=T1EH53 T1EH53 20195903 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG166724|UniProtKB=T1EYF7 T1EYF7 20201607 PTHR22504:SF0 REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;binding#GO:0005488 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG108413|UniProtKB=T1EEI7 T1EEI7 20194989 PTHR12258:SF5 JANUS-A/JANUS-B SEX-REGULATED PROTEIN JANUS-A-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG158461|UniProtKB=T1EMT5 T1EMT5 20197885 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162256|UniProtKB=T1ESF4 T1ESF4 20199504 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183124|UniProtKB=T1FJ60 T1FJ60 20208859 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993 HELRO|EnsemblGenome=HelroG187950|UniProtKB=T1FPI0 T1FPI0 20210727 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG108045|UniProtKB=T1EEE8 T1EEE8 20194950 PTHR42919:SF8 N-ALPHA-ACETYLTRANSFERASE N-ALPHA-ACETYLTRANSFERASE 50 acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 chromosome organization#GO:0051276;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840;mitotic sister chromatid cohesion#GO:0007064;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;transferase complex#GO:1990234;catalytic complex#GO:1902494 transferase#PC00220;acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG107238|UniProtKB=T1EE89 T1EE89 20194891 PTHR13325:SF3 PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;metabolic process#GO:0008152;proteolysis#GO:0006508;regulation of cellular response to stress#GO:0080135;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of biological process#GO:0050789;membrane protein proteolysis#GO:0033619;primary metabolic process#GO:0044238;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107367|UniProtKB=T1EEA0 T1EEA0 20194902 PTHR24348:SF65 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE ULK3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;response to starvation#GO:0042594;regulation of autophagy#GO:0010506;cellular component organization#GO:0016043;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;biological regulation#GO:0065007;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;response to nutrient levels#GO:0031667;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;regulation of metabolic process#GO:0019222;reticulophagy#GO:0061709;response to stress#GO:0006950;regulation of catabolic process#GO:0009894;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422 vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;autophagosome#GO:0005776 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG111611|UniProtKB=T1EFC8 T1EFC8 20195280 PTHR23318:SF27 ATP SYNTHASE GAMMA-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3 enzyme activator activity#GO:0008047;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;DNA damage response#GO:0006974;cellular response to stimulus#GO:0051716;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of double-strand break repair#GO:2000779;regulation of cellular response to stress#GO:0080135 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG179315|UniProtKB=T1FEJ2 T1FEJ2 20207241 PTHR24261:SF17 PLASMINOGEN-RELATED KRINGLE DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184803|UniProtKB=T1FM09 T1FM09 20209858 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG134076|UniProtKB=T1EI32 T1EI32 20196232 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG181592|UniProtKB=T1FH51 T1FH51 20208150 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110189|UniProtKB=T1EF03 T1EF03 20195155 PTHR43684:SF18 FAMILY NOT NAMED DODECENOYL-COA DELTA-ISOMERASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;lipid modification#GO:0030258 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG186277|UniProtKB=T1FNW6 T1FNW6 20210513 PTHR11570:SF0 S-ADENOSYLMETHIONINE DECARBOXYLASE S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME decarboxylase#PC00089;lyase#PC00144;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG166528|UniProtKB=T1EY76 T1EY76 20201526 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG191395|UniProtKB=T1FSY4 T1FSY4 20211931 PTHR24213:SF9 ACTIN-BINDING LIM PROTEIN UNCOORDINATED 115A, ISOFORM B-RELATED binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;lamellipodium assembly#GO:0030032;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 Axon guidance mediated by netrin#P00009>Ablim#P00358 HELRO|EnsemblGenome=HelroG185900|UniProtKB=T1FNF0 T1FNF0 20210347 PTHR24250:SF27 CHYMOTRYPSIN-RELATED PANCREATIC ELASTASE II serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG164142|UniProtKB=T1EUZ8 T1EUZ8 20200398 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162763|UniProtKB=T1ET37 T1ET37 20199737 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG182592|UniProtKB=T1FIF5 T1FIF5 20208604 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG75449|UniProtKB=T1G253 T1G253 20215151 PTHR45997:SF3 DNA LIGASE 4 DNA LIGASE 4 nucleotide binding#GO:0000166;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA binding#GO:0003677;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleic acid binding#GO:0003676;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;catalytic activity, acting on DNA#GO:0140097;ribonucleotide binding#GO:0032553;ligase activity#GO:0016874;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ATP binding#GO:0005524;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;double-strand break repair#GO:0006302 DNA repair complex#GO:1990391;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nonhomologous end joining complex#GO:0070419;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG64140|UniProtKB=T1FXQ1 T1FXQ1 20213599 PTHR45617:SF166 LEUCINE RICH REPEAT FAMILY PROTEIN LRRNT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164120|UniProtKB=T1EUY4 T1EUY4 20200384 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG101835|UniProtKB=T1ED72 T1ED72 20194524 PTHR48013:SF15 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 non-receptor serine/threonine protein kinase#PC00167 Huntington disease#P00029>SEK-1#P00792;Integrin signalling pathway#P00034>MEK#P00925;Apoptosis signaling pathway#P00006>SEK1#P00266;Angiogenesis#P00005>JNKK1#P00199;EGF receptor signaling pathway#P00018>MKK4,7#P00555;FGF signaling pathway#P00021>MKK4,7#P00637;Integrin signalling pathway#P00034>Jnk#P00951;Gonadotropin-releasing hormone receptor pathway#P06664>MKK4/7#P06760;FAS signaling pathway#P00020>MKK4#P00610;Ras Pathway#P04393>MKK4/7#P04565;p38 MAPK pathway#P05918>MKK4#P06034;Toll receptor signaling pathway#P00054>MKK4#P01366;Huntington disease#P00029>MAPKK4#P00787;Oxidative stress response#P00046>MKK4#P01138;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG164081|UniProtKB=T1EUW3 T1EUW3 20200363 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116792|UniProtKB=T1EGH9 T1EGH9 20195681 PTHR12587:SF14 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN AT31531P structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043;neuromuscular junction development#GO:0007528;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynaptic active zone#GO:0048786;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162289|UniProtKB=T1ESG6 T1ESG6 20199516 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;anterior/posterior pattern specification#GO:0009952;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of neurogenesis#GO:0050767;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG178956|UniProtKB=T1FDY6 T1FDY6 20207035 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG74733|UniProtKB=T1G1U9 T1G1U9 20215047 PTHR48013:SF11 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165 non-receptor serine/threonine protein kinase#PC00167 FGF signaling pathway#P00021>MKK3,6#P00625;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891;EGF receptor signaling pathway#P00018>MKK3,6#P00540;Huntington disease#P00029>SEK-1#P00792 HELRO|EnsemblGenome=HelroG182401|UniProtKB=T1FI52 T1FI52 20208501 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG99073|UniProtKB=T1G9Q8 T1G9Q8 20217804 PTHR10799:SF923 SNF2/RAD54 HELICASE FAMILY PROLIFERATION-ASSOCIATED SNF2-LIKE PROTEIN DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;chromatin binding#GO:0003682;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;heterochromatin formation#GO:0031507;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 DNA metabolism protein#PC00009;DNA helicase#PC00011 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG192818|UniProtKB=T1FUB9 T1FUB9 20212415 PTHR10921:SF4 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 establishment of organelle localization#GO:0051656;centrosome localization#GO:0051642;microtubule nucleation#GO:0007020;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;centrosome cycle#GO:0007098;protein polymerization#GO:0051258;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cellular localization#GO:0051641;spindle localization#GO:0051653;establishment or maintenance of cell polarity#GO:0007163;nuclear division#GO:0000280;microtubule-based transport#GO:0099111;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;establishment of vesicle localization#GO:0051650;chromosome localization#GO:0050000;organelle transport along microtubule#GO:0072384;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;protein-containing complex organization#GO:0043933;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;establishment of cell polarity#GO:0030010;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640;cytoskeleton-dependent intracellular transport#GO:0030705;cell migration#GO:0016477;microtubule polymerization or depolymerization#GO:0031109;vesicle localization#GO:0051648;establishment of spindle localization#GO:0051293;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;mitotic cell cycle process#GO:1903047;vesicle cytoskeletal trafficking#GO:0099518;microtubule polymerization#GO:0046785;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;transport#GO:0006810 kinetochore#GO:0000776;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG153307|UniProtKB=T1EL30 T1EL30 20197280 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70347|UniProtKB=T1G052 T1G052 20214450 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG163070|UniProtKB=T1ETM4 T1ETM4 20199924 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG172557|UniProtKB=T1F5I5 T1F5I5 20204084 PTHR12877:SF15 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG166253|UniProtKB=T1EXY1 T1EXY1 20201431 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN binding#GO:0005488;hormone binding#GO:0042562;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184509|UniProtKB=T1FLC8 T1FLC8 PTHR43507:SF23 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;NADH dehydrogenase activity#GO:0003954;catalytic activity#GO:0003824;small molecule binding#GO:0036094;binding#GO:0005488 generation of precursor metabolites and energy#GO:0006091;transport#GO:0006810;metabolic process#GO:0008152;aerobic respiration#GO:0009060;monoatomic ion transport#GO:0006811;proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular respiration#GO:0045333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;energy derivation by oxidation of organic compounds#GO:0015980;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG110109|UniProtKB=T1EEZ1 T1EEZ1 20195143 PTHR24253:SF103 TRANSMEMBRANE PROTEASE SERINE TRYPSIN catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG88521|UniProtKB=T1G736 T1G736 20216883 PTHR12544:SF52 GLUTAMINASE GLUTAMINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG187216|UniProtKB=T1FP78 T1FP78 20210625 PTHR42908:SF3 TRANSLATION ELONGATION FACTOR-RELATED ELONGATION FACTOR-LIKE GTPASE 1 ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924;translation elongation factor activity#GO:0003746;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817 gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;translational elongation#GO:0006414;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein metabolic process#GO:0019538;ribosome biogenesis#GO:0042254;organelle assembly#GO:0070925;ribosome assembly#GO:0042255;translation#GO:0006412 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829;ribonucleoprotein complex#GO:1990904 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG126005|UniProtKB=T1EH82 T1EH82 20195932 PTHR48034:SF37 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169501|UniProtKB=T1F207 T1F207 20202857 PTHR21500:SF0 TUBULIN-SPECIFIC CHAPERONE A TUBULIN-SPECIFIC CHAPERONE A tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG190882|UniProtKB=T1FSE0 T1FSE0 20211737 PTHR11037:SF20 TRANSCRIPTION FACTOR CP2 PROTEIN GRAINYHEAD sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG166741|UniProtKB=T1EYG6 T1EYG6 20201616 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66432|UniProtKB=T1FYL1 T1FYL1 20213909 PTHR28314:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG164480|UniProtKB=T1EVH4 T1EVH4 20200574 PTHR24014:SF4 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81068|UniProtKB=T1G485 T1G485 20215883 PTHR15691:SF6 WASH COMPLEX SUBUNIT 5 WASH COMPLEX SUBUNIT 5 cellular component assembly#GO:0022607;regulation of actin cytoskeleton organization#GO:0032956;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;actin filament polymerization#GO:0030041;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;organelle fission#GO:0048285;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG156722|UniProtKB=T1EM03 T1EM03 20197603 PTHR11071:SF593 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 chaperone#PC00072 HELRO|EnsemblGenome=HelroG162417|UniProtKB=T1ESM4 T1ESM4 20199574 PTHR23081:SF36 RNA POLYMERASE II CTD PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Transcription regulation by bZIP transcription factor#P00055>TFIIF#P01394;General transcription regulation#P00023>TFIIF#P00665 HELRO|EnsemblGenome=HelroG171029|UniProtKB=T1F3Q5 T1F3Q5 20203454 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG125459|UniProtKB=T1EH61 T1EH61 20195911 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG99246|UniProtKB=T1G9R7 T1G9R7 20217813 PTHR23147:SF22 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear speck#GO:0016607;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG172496|UniProtKB=T1F5E7 T1F5E7 20204046 PTHR48134:SF2 GLYCOPROTEIN 96-92-RELATED-RELATED TITIN-LIKE HELRO|EnsemblGenome=HelroG159293|UniProtKB=T1ENU6 T1ENU6 20198246 PTHR24256:SF470 TRYPTASE-RELATED SERINE PROTEASE 33 serine protease#PC00203 HELRO|EnsemblGenome=HelroG170948|UniProtKB=T1F3M3 T1F3M3 20203422 PTHR12458:SF11 ORF PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organism development#GO:0007275;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;anatomical structure formation involved in morphogenesis#GO:0048646;gamete generation#GO:0007276;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;anatomical structure morphogenesis#GO:0009653;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;sexual reproduction#GO:0019953 microtubule#GO:0005874;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG191370|UniProtKB=T1FSX5 T1FSX5 20211922 PTHR23189:SF102 RNA RECOGNITION MOTIF-CONTAINING PROTEIN NO-ON-TRANSIENT A RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183880|UniProtKB=T1FKA2 T1FKA2 20209251 PTHR12963:SF4 THYROID RECEPTOR INTERACTING PROTEIN RELATED TRIP4_RQT4 C2HC5-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN translational elongation#GO:0006414;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;biosynthetic process#GO:0009058;proteasomal protein catabolic process#GO:0010498;gene expression#GO:0010467;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;translation#GO:0006412;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;rescue of stalled cytosolic ribosome#GO:0072344;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cytoplasmic translation#GO:0002181;catabolic process#GO:0009056;protein biosynthetic process#GO:0160307 protein-containing complex#GO:0032991 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG100404|UniProtKB=T1ECZ5 T1ECZ5 20194447 PTHR11811:SF25 6-PHOSPHOGLUCONATE DEHYDROGENASE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;purine nucleotide binding#GO:0017076;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;phosphogluconate dehydrogenase (decarboxylating) activity#GO:0004616;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094 pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;pentose-phosphate shunt, oxidative branch#GO:0009051;nucleobase-containing small molecule metabolic process#GO:0055086;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing compound metabolic process#GO:0006139 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 Pentose phosphate pathway#P02762>Gluconate Dehydrogenase#P03070 HELRO|EnsemblGenome=HelroG82547|UniProtKB=T1G4T6 T1G4T6 20216084 PTHR11707:SF28 L-ASPARAGINASE 60 KDA LYSOPHOSPHOLIPASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;amidase activity#GO:0004040;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 HELRO|EnsemblGenome=HelroG193504|UniProtKB=T1FV24 T1FV24 20212670 PTHR12984:SF15 SCY1-RELATED S/T PROTEIN KINASE-LIKE PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG132330|UniProtKB=T1EHX8 T1EHX8 20196178 PTHR24247:SF265 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR DM1 molecular transducer activity#GO:0060089;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;signaling#GO:0023052 dendritic tree#GO:0097447;dendrite#GO:0030425;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;synapse#GO:0045202;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG161940|UniProtKB=T1ES21 T1ES21 20199371 PTHR21650:SF4 MEMBRALIN/KINETOCHORE PROTEIN NUF2 MEMBRALIN response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of response to endoplasmic reticulum stress#GO:1905897;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of ERAD pathway#GO:1904292;response to endoplasmic reticulum stress#GO:0034976;positive regulation of protein metabolic process#GO:0051247;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;regulation of protein catabolic process#GO:0042176;regulation of cellular response to stress#GO:0080135;positive regulation of protein catabolic process#GO:0045732 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG125879|UniProtKB=T1EH74 T1EH74 20195924 PTHR23291:SF131 BAX INHIBITOR-RELATED TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7 calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;transporter activity#GO:0005215 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to unfolded protein#GO:0006986;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;biological regulation#GO:0065007 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176919|UniProtKB=T1FB18 T1FB18 20206017 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159928|UniProtKB=T1EPK5 T1EPK5 20198505 PTHR10151:SF114 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG159592|UniProtKB=T1EP77 T1EP77 20198377 PTHR12758:SF25 APOPTOSIS INHIBITOR 5-RELATED APOPTOSIS INHIBITOR 5 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG91609|UniProtKB=T1G861 T1G861 20217258 PTHR12675:SF12 MUSCLEBLIND-LIKE PROTEIN PROTEIN MUSCLEBLIND nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG159956|UniProtKB=T1EPL4 T1EPL4 20198514 PTHR44303:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 metabolic process#GO:0008152;regulation of anatomical structure size#GO:0090066;process utilizing autophagic mechanism#GO:0061919;regulation of biological quality#GO:0065008;vacuole organization#GO:0007033;cellular component organization or biogenesis#GO:0071840;autophagosome organization#GO:1905037;cellular process#GO:0009987;regulation of cellular component size#GO:0032535;autophagy#GO:0006914;cellular component organization#GO:0016043;organelle organization#GO:0006996;macroautophagy#GO:0016236;biological regulation#GO:0065007;catabolic process#GO:0009056 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184048|UniProtKB=T1FKH4 T1FKH4 20209323 PTHR37404:SF1 HCG1796489 STABILIZER OF AXONEMAL MICROTUBULES 3 HELRO|EnsemblGenome=HelroG182229|UniProtKB=T1FHY7 T1FHY7 20208436 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402 HELRO|EnsemblGenome=HelroG85716|UniProtKB=T1G622 T1G622 20216519 PTHR43448:SF2 PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound biosynthetic process#GO:0006779;cellular process#GO:0009987;heme biosynthetic process#GO:0006783;pigment metabolic process#GO:0042440;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;tetrapyrrole biosynthetic process#GO:0033014 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 Heme biosynthesis#P02746>Protoheme IX farnesyl transferase#P02982 HELRO|EnsemblGenome=HelroG101987|UniProtKB=T1ED77 T1ED77 20194529 PTHR11566:SF212 DYNAMIN DYNAMIN hydrolase activity#GO:0016787;protein binding#GO:0005515;GTPase activity#GO:0003924;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG157108|UniProtKB=T1EM61 T1EM61 20197661 PTHR10552:SF11 U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' binding#GO:0005488;nucleic acid binding#GO:0003676;snRNA binding#GO:0017069;RNA binding#GO:0003723 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 spliceosomal complex#GO:0005681;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;U2 snRNP#GO:0005686;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG168556|UniProtKB=T1F0Q3 T1F0Q3 20202403 PTHR24117:SF9 AGAP007537-PB BCL-6 COREPRESSOR PCGF1 BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG111413|UniProtKB=T1EFB1 T1EFB1 20195263 PTHR14898:SF0 ENHANCER OF POLYCOMB ENHANCER OF POLYCOMB-LIKE PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG182144|UniProtKB=T1FHT7 T1FHT7 20208386 PTHR47522:SF2 SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1 PROTEIN SALVADOR HOMOLOG 1 positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;hippo signaling#GO:0035329;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;negative regulation of cell population proliferation#GO:0008285;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG189820|UniProtKB=T1FRE2 T1FRE2 20211389 PTHR12348:SF26 TSC22 PROTEIN TSCT-1 HELRO|EnsemblGenome=HelroG188652|UniProtKB=T1FQ81 T1FQ81 20210978 PTHR18916:SF88 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule plus-end#GO:0035371;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;nucleus#GO:0005634;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule end#GO:1990752;cell cortex#GO:0005938 chaperone#PC00072 HELRO|EnsemblGenome=HelroG165821|UniProtKB=T1EXB9 T1EXB9 20201219 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG158795|UniProtKB=T1EN99 T1EN99 20198049 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG177006|UniProtKB=T1FB47 T1FB47 20206046 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 10 HELRO|EnsemblGenome=HelroG165722|UniProtKB=T1EX75 T1EX75 20201175 PTHR31815:SF1 AGAP005329-PA TRANSMEMBRANE PROTEIN 200C HELRO|EnsemblGenome=HelroG172376|UniProtKB=T1F586 T1F586 20203985 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114815|UniProtKB=T1EG46 T1EG46 20195548 PTHR12430:SF0 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20 mitochondrial transport#GO:0006839;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;establishment of RNA localization#GO:0051236;protein localization to mitochondrion#GO:0070585;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;protein transport#GO:0015031;mitochondrial transmembrane transport#GO:1990542;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG74778|UniProtKB=T1G1V4 T1G1V4 20215052 PTHR45881:SF7 CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED HELRO|EnsemblGenome=HelroG185410|UniProtKB=T1FMS1 T1FMS1 20210120 PTHR24320:SF292 RETINOL DEHYDROGENASE WW DOMAIN-CONTAINING OXIDOREDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188195|UniProtKB=T1FPR6 T1FPR6 20210813 PTHR45686:SF4 ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG170381|UniProtKB=T1F2Z2 T1F2Z2 20203191 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING IP01257P-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG183706|UniProtKB=T1FK31 T1FK31 20209180 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164792|UniProtKB=T1EVT4 T1EVT4 20200684 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109239|UniProtKB=T1EER8 T1EER8 20195070 PTHR44054:SF2 SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE NADPH-DEPENDENT QUINONE OXIDOREDUCTASE VAT1L-RELATED Huntington disease#P00029>PIG3#G01535 HELRO|EnsemblGenome=HelroG90303|UniProtKB=T1G7P0 T1G7P0 20217087 PTHR10856:SF44 CORONIN CORONIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;actin filament#GO:0005884;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG176127|UniProtKB=T1FA64 T1FA64 20205713 PTHR24121:SF23 NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED ANKYRIN REPEAT PROTEIN A HELRO|EnsemblGenome=HelroG166552|UniProtKB=T1EY86 T1EY86 20201536 PTHR11106:SF27 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED POLY [ADP-RIBOSE] POLYMERASE HELRO|EnsemblGenome=HelroG124201|UniProtKB=T1EH03 T1EH03 20195853 PTHR44313:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;protein-containing complex disassembly#GO:0032984;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular component disassembly#GO:0022411;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG159456|UniProtKB=T1EP21 T1EP21 20198321 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG175580|UniProtKB=T1F9E3 T1F9E3 20205442 PTHR18853:SF10 FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED FHA DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG195125|UniProtKB=T1FWS2 T1FWS2 20213267 PTHR24403:SF67 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG166392|UniProtKB=T1EY30 T1EY30 20201480 PTHR21190:SF1 GH10077P GH10077P HELRO|EnsemblGenome=HelroG172748|UniProtKB=T1F5W5 T1F5W5 20204214 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80468|UniProtKB=T1G414 T1G414 20215812 PTHR24353:SF160 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell adhesion#GO:0007155 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Endothelin signaling pathway#P00019>PKA#P00570;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862 HELRO|EnsemblGenome=HelroG189414|UniProtKB=T1FR15 T1FR15 20211262 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG188599|UniProtKB=T1FQ59 T1FQ59 20210956 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG169160|UniProtKB=T1F1I1 T1F1I1 20202681 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180252|UniProtKB=T1FFN0 T1FFN0 20207629 PTHR21588:SF18 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6 MICOS COMPLEX SUBUNIT MIC19 cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;mitochondrial membrane organization#GO:0007006;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866 HELRO|EnsemblGenome=HelroG168898|UniProtKB=T1F140 T1F140 20202540 PTHR24044:SF512 NOTCH LIGAND FAMILY MEMBER PROTEIN LIN-12 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Next#P01103;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120 HELRO|EnsemblGenome=HelroG122015|UniProtKB=T1EGT6 T1EGT6 20195786 PTHR12223:SF28 VESICULAR MANNOSE-BINDING LECTIN LECTIN, MANNOSE BINDING 1 LIKE small molecule binding#GO:0036094;binding#GO:0005488;carbohydrate binding#GO:0030246;monosaccharide binding#GO:0048029 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907 endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG64031|UniProtKB=T1FXN5 T1FXN5 20213583 PTHR10176:SF3 GLYCOGEN SYNTHASE GLYCOGEN [STARCH] SYNTHASE glucosyltransferase activity#GO:0046527;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;glycogen biosynthetic process#GO:0005978;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;glycogen metabolic process#GO:0005977;glucan biosynthetic process#GO:0009250;polysaccharide biosynthetic process#GO:0000271;energy reserve metabolic process#GO:0006112 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG185993|UniProtKB=T1FNJ1 T1FNJ1 20210388 PTHR10709:SF2 ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1 ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT cellular component organization or biogenesis#GO:0071840;cortical actin cytoskeleton organization#GO:0030866;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Arp2/3#P00912;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Huntington disease#P00029>Arp2/3 complex#P00811 HELRO|EnsemblGenome=HelroG188995|UniProtKB=T1FQJ5 T1FQJ5 20211092 PTHR12299:SF17 HYALURONIC ACID-BINDING PROTEIN 4 AT19571P-RELATED RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164831|UniProtKB=T1EVV1 T1EVV1 20200701 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181286|UniProtKB=T1FGU5 T1FGU5 20208044 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158469|UniProtKB=T1EMU0 T1EMU0 20197890 PTHR39267:SF1 SURVIVAL MOTOR NEURON-LIKE PROTEIN 1 SURVIVAL OF MOTOR NEURON HELRO|EnsemblGenome=HelroG188740|UniProtKB=T1FQB5 T1FQB5 20211012 PTHR12650:SF15 40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI RIBOSOMAL PROTEIN S30, ISOFORM A cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG67702|UniProtKB=T1FZ43 T1FZ43 20214091 PTHR24291:SF48 CYTOCHROME P450 FAMILY 4 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG95956|UniProtKB=T1G991 T1G991 20217638 PTHR42693:SF47 ARYLSULFATASE FAMILY MEMBER N-ACETYLGALACTOSAMINE-6-SULFATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG172429|UniProtKB=T1F5B5 T1F5B5 20204014 PTHR11801:SF67 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SUBFAMILY NOT NAMED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG169706|UniProtKB=T1F291 T1F291 20202941 PTHR12482:SF67 LIPASE ROG1-RELATED-RELATED DUF676 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788 metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG185827|UniProtKB=T1FNC3 T1FNC3 20210320 PTHR19211:SF117 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3 nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524;small molecule binding#GO:0036094;binding#GO:0005488 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG165074|UniProtKB=T1EW93 T1EW93 20200843 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG185497|UniProtKB=T1FMW3 T1FMW3 20210162 PTHR45883:SF2 HSC70-INTERACTING PROTEIN HSC70-INTERACTING PROTEIN heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG74554|UniProtKB=T1G1S6 T1G1S6 20215024 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG170325|UniProtKB=T1F2X5 T1F2X5 20203174 PTHR45697:SF2 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2 ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG76443|UniProtKB=T1G2J9 T1G2J9 20215297 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG176231|UniProtKB=T1FAB5 T1FAB5 20205764 PTHR11202:SF3 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED PROTEIN WITH EVH-1 DOMAIN, ISOFORM C protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488 negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG131091|UniProtKB=T1EHV2 T1EHV2 20196152 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG173594|UniProtKB=T1F701 T1F701 20204600 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG163206|UniProtKB=T1ETS8 T1ETS8 20199978 PTHR14402:SF10 RECEPTOR TRANSPORTING PROTEIN RECEPTOR-TRANSPORTING PROTEIN 3 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488 localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;cellular component organization#GO:0016043;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;membrane organization#GO:0061024;protein targeting#GO:0006605;protein insertion into membrane#GO:0051205 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68693|UniProtKB=T1FZI4 T1FZI4 20214232 PTHR10656:SF70 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-LIKE transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG193797|UniProtKB=T1FVD1 T1FVD1 20212777 PTHR12955:SF1 SARCOMA ANTIGEN NY-SAR-95-RELATED INTEGRATOR COMPLEX SUBUNIT 13 localization#GO:0051179;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;centrosome localization#GO:0051642;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;integrator complex#GO:0032039 HELRO|EnsemblGenome=HelroG166079|UniProtKB=T1EXQ1 T1EXQ1 20201351 PTHR22802:SF396 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188291|UniProtKB=T1FPU2 T1FPU2 20210839 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG188605|UniProtKB=T1FQ62 T1FQ62 20210959 PTHR24070:SF459 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP1 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;regulation of transport#GO:0051049;regulation of localization#GO:0032879;negative regulation of biological process#GO:0048519;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of neurotransmitter secretion#GO:0046928;response to stimulus#GO:0050896;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of secretion by cell#GO:1903530;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;negative regulation of cellular process#GO:0048523;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;cell communication#GO:0007154;regulation of secretion#GO:0051046;intracellular signal transduction#GO:0035556;regulation of exocytosis#GO:0017157;response to nitrogen compound#GO:1901698 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HELRO|EnsemblGenome=HelroG74483|UniProtKB=T1G1R8 T1G1R8 20215016 PTHR13555:SF5 C2H2 ZINC FINGER CGI-62-RELATED C2HC-TYPE ZINC-FINGER DOMAIN-CONTAINING PROTEIN C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG183463|UniProtKB=T1FJQ1 T1FJQ1 20209050 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR MELATONIN RECEPTOR PDCR-1 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG74146|UniProtKB=T1G1M8 T1G1M8 20214976 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG71732|UniProtKB=T1G0Q8 T1G0Q8 20214656 PTHR11202:SF3 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED PROTEIN WITH EVH-1 DOMAIN, ISOFORM C protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515 negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of response to stimulus#GO:0048585;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189900|UniProtKB=T1FRG6 T1FRG6 20211413 PTHR34479:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 30 COILED-COIL DOMAIN-CONTAINING PROTEIN 30 HELRO|EnsemblGenome=HelroG81330|UniProtKB=T1G4D1 T1G4D1 20215929 PTHR12718:SF2 CELL CYCLE CONTROL PROTEIN CWF15 SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG162828|UniProtKB=T1ET83 T1ET83 20199783 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81208|UniProtKB=T1G4B3 T1G4B3 20215911 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG193201|UniProtKB=T1FUQ9 T1FUQ9 20212555 PTHR20961:SF167 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 acetylglucosaminyltransferase activity#GO:0008375;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182082|UniProtKB=T1FHP6 T1FHP6 20208345 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191111|UniProtKB=T1FSL7 T1FSL7 20211814 PTHR14948:SF25 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG79668|UniProtKB=T1G3R9 T1G3R9 20215717 PTHR11566:SF212 DYNAMIN DYNAMIN GTPase activity#GO:0003924;microtubule binding#GO:0008017;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG162360|UniProtKB=T1ESK1 T1ESK1 20199551 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189765|UniProtKB=T1FRC8 T1FRC8 20211375 PTHR46459:SF1 E1A-BINDING PROTEIN P400-RELATED E1A-BINDING PROTEIN P400 chromatin binding#GO:0003682;binding#GO:0005488 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 catalytic complex#GO:1902494;Swr1 complex#GO:0000812;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;H4 histone acetyltransferase complex#GO:1902562;nuclear chromosome#GO:0000228;intracellular organelle lumen#GO:0070013;protein acetyltransferase complex#GO:0031248;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;acetyltransferase complex#GO:1902493;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG89733|UniProtKB=T1G7G8 T1G7G8 20217015 PTHR45080:SF40 CONTACTIN 5 STRETCHIN-MLCK-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell junction organization#GO:0034330;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell adhesion#GO:0007155 axon#GO:0030424;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell body#GO:0044297;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG176266|UniProtKB=T1FAC5 T1FAC5 20205774 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185259|UniProtKB=T1FMK5 T1FMK5 20210054 PTHR18966:SF594 IONOTROPIC GLUTAMATE RECEPTOR IONOTROPIC RECEPTOR 93A molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215 regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG179172|UniProtKB=T1FEA8 T1FEA8 20207157 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG154558|UniProtKB=T1ELF2 T1ELF2 20197402 PTHR10745:SF0 GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2 GLYCINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;translation#GO:0006412;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG106930|UniProtKB=T1EE60 T1EE60 20194862 PTHR10953:SF254 UBIQUITIN-ACTIVATING ENZYME E1 ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;ligase activity#GO:0016874;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;tRNA wobble position uridine thiolation#GO:0002143;protein modification by small protein conjugation#GO:0032446;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;protein modification by small protein conjugation or removal#GO:0070647;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule modification#GO:0043412;tRNA thio-modification#GO:0034227;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG178544|UniProtKB=T1FDC4 T1FDC4 20206823 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177179|UniProtKB=T1FBB9 T1FBB9 20206118 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD CASPASE DRONC positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG181053|UniProtKB=T1FGK2 T1FGK2 20207951 PTHR14098:SF14 SH2 DOMAIN CONTAINING PROTEIN SH2 DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185555|UniProtKB=T1FMZ2 T1FMZ2 20210191 PTHR46551:SF1 SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG83198|UniProtKB=T1G518 T1G518 20216166 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90340|UniProtKB=T1G7P4 T1G7P4 20217091 PTHR14517:SF6 RIB43A-RELATED RE41410P cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG142999|UniProtKB=T1EJ85 T1EJ85 20196635 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX DOMAIN-CONTAINING PROTEIN RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG190709|UniProtKB=T1FS80 T1FS80 20211677 PTHR42757:SF48 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG112638|UniProtKB=T1EFL0 T1EFL0 20195362 PTHR11532:SF57 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE E catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190 HELRO|EnsemblGenome=HelroG173963|UniProtKB=T1F7F2 T1F7F2 20204751 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE MGP4 glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194898|UniProtKB=T1FWJ4 T1FWJ4 20213189 PTHR43544:SF7 SHORT-CHAIN DEHYDROGENASE/REDUCTASE DEHYDROGENASES, SHORT CHAIN oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG72329|UniProtKB=T1G0Y4 T1G0Y4 20214732 PTHR19297:SF191 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG184377|UniProtKB=T1FL31 T1FL31 20209530 PTHR24139:SF36 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 PHOSPHOLIPASE A2 hydrolase activity#GO:0016787;acyl-CoA hydrolase activity#GO:0016289;fatty acyl-CoA hydrolase activity#GO:0047617;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;thiolester hydrolase activity#GO:0016790;A2-type glycerophospholipase activity#GO:0004623;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;deacylase activity#GO:0160215;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of macromolecule metabolic process#GO:0060255;regulation of lipid biosynthetic process#GO:0046890;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of lipid metabolic process#GO:0019216;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG137131|UniProtKB=T1EIH8 T1EIH8 20196378 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191207|UniProtKB=T1FSQ8 T1FSQ8 20211855 PTHR24139:SF36 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 PHOSPHOLIPASE A2 hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;deacylase activity#GO:0160215;A2-type glycerophospholipase activity#GO:0004623;thiolester hydrolase activity#GO:0016790;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;fatty acyl-CoA hydrolase activity#GO:0047617;acyl-CoA hydrolase activity#GO:0016289;hydrolase activity#GO:0016787 positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG138704|UniProtKB=T1EIW6 T1EIW6 20196516 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG178254|UniProtKB=T1FCZ9 T1FCZ9 20206698 PTHR10159:SF544 DUAL SPECIFICITY PROTEIN PHOSPHATASE MAP KINASE PHOSPHATASE WITH LEUCINE-RICH REPEATS PROTEIN 3 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG66433|UniProtKB=T1FYL2 T1FYL2 20213910 PTHR10983:SF24 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG114367|UniProtKB=T1EG10 T1EG10 20195512 PTHR23255:SF71 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE BABO molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;activin binding#GO:0048185;kinase activity#GO:0016301 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;activin receptor signaling pathway#GO:0032924;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;signaling#GO:0023052 protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796 serine/threonine protein kinase receptor#PC00205 Activin beta signaling pathway#P06210>BABO#P06231;MYO signaling pathway#P06215>BABO#P06310;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;ALP23B signaling pathway#P06209>BABO#P06220;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442 HELRO|EnsemblGenome=HelroG172591|UniProtKB=T1F5K5 T1F5K5 20204104 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112157|UniProtKB=T1EFH3 T1EFH3 20195325 PTHR43740:SF3 LEUCYL-TRNA SYNTHETASE LEUCINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;translation#GO:0006412;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG110019|UniProtKB=T1EEY3 T1EEY3 20195135 PTHR23050:SF547 CALCIUM BINDING PROTEIN AT10229P-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 calcium-binding protein#PC00060;calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG112977|UniProtKB=T1EFP0 T1EFP0 20195392 PTHR45882:SF3 PITUITARY HOMEOBOX HOMOLOG PTX1 PITUITARY HOMEOBOX HOMOLOG PTX1 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG194684|UniProtKB=T1FWB3 T1FWB3 20213109 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12710)-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG108545|UniProtKB=T1EEK2 T1EEK2 20195004 PTHR10153:SF44 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;calmodulin binding#GO:0005516;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;binding#GO:0005488;gated channel activity#GO:0022836;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 membrane#GO:0016020;cell periphery#GO:0071944;cell body#GO:0044297;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477 voltage-gated ion channel#PC00241;ion channel#PC00133 HELRO|EnsemblGenome=HelroG193616|UniProtKB=T1FV66 T1FV66 20212712 PTHR42884:SF39 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 1 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;peptide hormone processing#GO:0016486;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;biosynthetic process#GO:0009058;proteolysis#GO:0006508;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817 endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;neuron projection#GO:0043005;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;extracellular region#GO:0005576;intracellular organelle#GO:0043229 serine protease#PC00203 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG192978|UniProtKB=T1FUH2 T1FUH2 20212468 PTHR15710:SF261 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE E3 UBIQUITIN TRANSFERASE positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG65701|UniProtKB=T1FYB6 T1FYB6 20213814 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of translational initiation#GO:0006446;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG193045|UniProtKB=T1FUK1 T1FUK1 20212497 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG150486|UniProtKB=T1EKF8 T1EKF8 20197058 PTHR24055:SF561 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 7 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>ERK#P01211;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;CCKR signaling map#P06959>MAPK7#P07021;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Interleukin signaling pathway#P00036>ERK#P00965;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Endothelin signaling pathway#P00019>ERK#P00566;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Apoptosis signaling pathway#P00006>MAPK#P00269;FGF signaling pathway#P00021>ERK1-2#P00627;PDGF signaling pathway#P00047>ERK#P01143 HELRO|EnsemblGenome=HelroG187684|UniProtKB=T1FPB9 T1FPB9 20210666 PTHR46596:SF1 SORTING NEXIN-4 SORTING NEXIN-4 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981 regulation of autophagosome assembly#GO:2000785;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;positive regulation of metabolic process#GO:0009893;localization#GO:0051179;protein transport#GO:0015031;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;positive regulation of macroautophagy#GO:0016239;transport#GO:0006810;establishment of localization#GO:0051234;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;intracellular protein localization#GO:0008104;regulation of macroautophagy#GO:0016241;regulation of metabolic process#GO:0019222;positive regulation of autophagy#GO:0010508;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;early endosome membrane#GO:0031901;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193363|UniProtKB=T1FUX0 T1FUX0 20212616 PTHR12794:SF0 GEMIN2 GEM-ASSOCIATED PROTEIN 2 cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;spliceosomal snRNP assembly#GO:0000387;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SMN complex#GO:0032797;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG184849|UniProtKB=T1FM29 T1FM29 20209878 PTHR15907:SF161 DUF614 FAMILY PROTEIN-RELATED DUF614 DOMAIN PROTEIN HELRO|EnsemblGenome=HelroG170360|UniProtKB=T1F2Y9 T1F2Y9 20203188 PTHR13793:SF169 PHD FINGER PROTEINS BROMODOMAIN-CONTAINING PROTEIN HOMOLOG chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG191153|UniProtKB=T1FSN6 T1FSN6 20211833 PTHR23423:SF17 ORGANIC SOLUTE TRANSPORTER-RELATED IP17403P transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG184873|UniProtKB=T1FM40 T1FM40 20209889 PTHR10980:SF3 RHO GDP-DISSOCIATION INHIBITOR RHO GDP-DISSOCIATION INHIBITOR 3 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane#GO:0016020 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG179809|UniProtKB=T1FF64 T1FF64 20207463 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG176189|UniProtKB=T1FAA0 T1FAA0 20205749 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82136|UniProtKB=T1G4N4 T1G4N4 20216032 PTHR14208:SF2 BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN PROTEIN KRASAVIETZ cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG192296|UniProtKB=T1FTT0 T1FTT0 20212227 PTHR14596:SF77 ZINC FINGER PROTEIN TRANSCRIPTIONAL REGULATOR MNL1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 response to stress#GO:0006950;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG174875|UniProtKB=T1F8K1 T1F8K1 20205150 PTHR46515:SF1 TATA ELEMENT MODULATORY FACTOR TMF1 TATA ELEMENT MODULATORY FACTOR cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG185404|UniProtKB=T1FMR8 T1FMR8 20210117 PTHR16356:SF1 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG191309|UniProtKB=T1FSV4 T1FSV4 20211901 PTHR18934:SF136 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX35-RELATED ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;isomerase activity#GO:0016853;helicase activity#GO:0004386 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174284|UniProtKB=T1F7X8 T1F7X8 20204927 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82362|UniProtKB=T1G4R1 T1G4R1 20216059 PTHR24208:SF105 LIM/HOMEOBOX PROTEIN LHX DLIM1 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG193389|UniProtKB=T1FUX9 T1FUX9 20212625 PTHR24241:SF200 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;biological regulation#GO:0065007;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189761|UniProtKB=T1FRC6 T1FRC6 20211373 PTHR11670:SF75 ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER CYTOPLASMIC ACONITATE HYDRATASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824;iron-sulfur cluster binding#GO:0051536;RNA binding#GO:0003723;lyase activity#GO:0016829;small molecule binding#GO:0036094;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 homeostatic process#GO:0042592;intracellular iron ion homeostasis#GO:0006879;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 Methylcitrate cycle#P02754>Aconitase#P03028 HELRO|EnsemblGenome=HelroG109698|UniProtKB=T1EEV8 T1EEV8 20195110 PTHR24340:SF41 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN CEH-24-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG75856|UniProtKB=T1G2B3 T1G2B3 20215211 PTHR10694:SF148 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;protein demethylase activity#GO:0140457;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG191259|UniProtKB=T1FST3 T1FST3 20211880 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG75648|UniProtKB=T1G283 T1G283 20215181 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P cation binding#GO:0043169;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076 cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;response to starvation#GO:0042594;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of carbohydrate biosynthetic process#GO:0043255;cellular response to starvation#GO:0009267;regulation of carbohydrate metabolic process#GO:0006109;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG175853|UniProtKB=T1F9S2 T1F9S2 20205571 PTHR47160:SF13 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169150|UniProtKB=T1F1H2 T1F1H2 20202672 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105068|UniProtKB=T1EDQ4 T1EDQ4 20194706 PTHR24409:SF438 ZINC FINGER PROTEIN 142 CHROMATIN MODIFICATION-RELATED PROTEIN YNG2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG169548|UniProtKB=T1F230 T1F230 20202880 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;transporter activity#GO:0005215;channel activity#GO:0015267;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857 homeostatic process#GO:0042592;metal ion transport#GO:0030001;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG116613|UniProtKB=T1EGG5 T1EGG5 20195667 PTHR19237:SF20 NUCLEOBINDIN NUCLEOBINDIN 1 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG95271|UniProtKB=T1G953 T1G953 20217600 PTHR43353:SF14 SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Gamma-aminobutyric acid synthesis#P04384>Succinic semialdehyde dehydrogenase#P04481;Aminobutyrate degradation#P02726>Succinate semi-aldehyde dehydrogenase#P02824 HELRO|EnsemblGenome=HelroG105279|UniProtKB=T1EDS8 T1EDS8 20194730 PTHR44111:SF2 ELONGATOR COMPLEX PROTEIN 2 ELONGATOR COMPLEX PROTEIN 2 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;elongator holoenzyme complex#GO:0033588 HELRO|EnsemblGenome=HelroG165236|UniProtKB=T1EWH4 T1EWH4 20200924 PTHR42999:SF2 ANTIBIOTIC RESISTANCE PROTEIN MCBG SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG172299|UniProtKB=T1F569 T1F569 20203968 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171155|UniProtKB=T1F3V7 T1F3V7 20203506 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 snRNA metabolic process#GO:0016073;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;nuclear mRNA surveillance#GO:0071028;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG168549|UniProtKB=T1F0P9 T1F0P9 20202399 PTHR21683:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED CILIA AND FLAGELLA ASSOCIATED PROTEIN 100 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG176639|UniProtKB=T1FAR3 T1FAR3 20205912 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407 HELRO|EnsemblGenome=HelroG172534|UniProtKB=T1F5H2 T1F5H2 20204071 PTHR23322:SF1 FAS-ASSOCIATED PROTEIN FAS-ASSOCIATED FACTOR 2 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to stimulus#GO:0050896;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG85703|UniProtKB=T1G619 T1G619 20216516 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG185481|UniProtKB=T1FMV7 T1FMV7 20210156 PTHR11530:SF11 D-AMINO ACID OXIDASE D-AMINO ACID OXIDASE 2, ISOFORM A catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidase#PC00175 HELRO|EnsemblGenome=HelroG81905|UniProtKB=T1G4K6 T1G4K6 20216004 PTHR46002:SF5 EG:114D9.1 PROTEIN-RELATED EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG169288|UniProtKB=T1F1Q6 T1F1Q6 20202756 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180986|UniProtKB=T1FGI0 T1FGI0 20207929 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 23 HELRO|EnsemblGenome=HelroG185886|UniProtKB=T1FNE4 T1FNE4 20210341 PTHR10264:SF127 BAND 7 PROTEIN-RELATED BAND 7 PROTEIN CG42540 channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG174776|UniProtKB=T1F8G5 T1F8G5 20205114 PTHR15090:SF0 SEQUESTOSOME 1-RELATED SEQUESTOSOME-1 K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;polyubiquitin modification-dependent protein binding#GO:0031593;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;modification-dependent protein binding#GO:0140030;kinase binding#GO:0019900 metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;endosome organization#GO:0007032;process utilizing autophagic mechanism#GO:0061919;vesicle organization#GO:0016050;organelle organization#GO:0006996;cellular component organization#GO:0016043;autophagy#GO:0006914;cellular process#GO:0009987;catabolic process#GO:0009056;endomembrane system organization#GO:0010256;macroautophagy#GO:0016236 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 HELRO|EnsemblGenome=HelroG170128|UniProtKB=T1F2P3 T1F2P3 20203092 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG181587|UniProtKB=T1FH50 T1FH50 20208149 PTHR23253:SF78 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED translation initiation factor activity#GO:0003743;RNA binding#GO:0003723;translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG170263|UniProtKB=T1F2U7 T1F2U7 20203146 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG177385|UniProtKB=T1FBL5 T1FBL5 20206214 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG184040|UniProtKB=T1FKH0 T1FKH0 20209319 PTHR15414:SF0 OS-9-RELATED ENDOPLASMIC RETICULUM LECTIN 1 signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to unfolded protein#GO:0006986;cellular localization#GO:0051641;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;protein metabolic process#GO:0019538;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;biological regulation#GO:0065007;macromolecule localization#GO:0033036;endoplasmic reticulum unfolded protein response#GO:0030968;intracellular protein localization#GO:0008104;macromolecule metabolic process#GO:0043170 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG189564|UniProtKB=T1FR57 T1FR57 20211304 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG115111|UniProtKB=T1EG66 T1EG66 20195568 PTHR22957:SF653 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN FI17814P1 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG164973|UniProtKB=T1EW17 T1EW17 20200767 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164455|UniProtKB=T1EVF7 T1EVF7 20200557 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG110726|UniProtKB=T1EF45 T1EF45 20195197 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cellular developmental process#GO:0048869;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;developmental process#GO:0032502;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG162248|UniProtKB=T1ESE7 T1ESE7 20199497 PTHR23351:SF24 FOS TRANSCRIPTION FACTOR-RELATED ACTIVATING TRANSCRIPTION FACTOR 3-RELATED basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG175511|UniProtKB=T1F9C4 T1F9C4 20205423 PTHR13282:SF6 PROTEIN FAM32A PROTEIN FAM32A membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG189692|UniProtKB=T1FR94 T1FR94 20211341 PTHR14186:SF27 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG100575|UniProtKB=T1ED06 T1ED06 20194458 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG194833|UniProtKB=T1FWG8 T1FWG8 20213163 PTHR24347:SF424 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG74054|UniProtKB=T1G1L8 T1G1L8 20214966 PTHR23055:SF172 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG193313|UniProtKB=T1FUV4 T1FUV4 20212600 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG110857|UniProtKB=T1EF57 T1EF57 20195209 PTHR43674:SF17 NITRILASE C965.09-RELATED BETA-UREIDOPROPIONASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Pyrimidine Metabolism#P02771>Beta-Ureidopropionase#P03127 HELRO|EnsemblGenome=HelroG165596|UniProtKB=T1EX21 T1EX21 20201121 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG164707|UniProtKB=T1EVR2 T1EVR2 20200662 PTHR20914:SF9 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8 UPAR_LY6 DOMAIN-CONTAINING PROTEIN COLD scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG111131|UniProtKB=T1EF85 T1EF85 20195237 PTHR46116:SF51 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70799|UniProtKB=T1G0C3 T1G0C3 20214521 PTHR22811:SF14 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN LP01981P-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization#GO:0016043;Golgi organization#GO:0007030 endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184156|UniProtKB=T1FKP3 T1FKP3 20209392 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182602|UniProtKB=T1FIG3 T1FIG3 20208612 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG90448|UniProtKB=T1G7R4 T1G7R4 20217111 PTHR24092:SF150 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657 organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043;localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;lipid transport#GO:0006869;biological regulation#GO:0065007;phospholipid transport#GO:0015914;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG184942|UniProtKB=T1FM70 T1FM70 20209919 PTHR48082:SF2 ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL ATP SYNTHASE F(1) COMPLEX SUBUNIT ALPHA, MITOCHONDRIAL monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;ATP binding#GO:0005524;monoatomic ion channel activity#GO:0005216;heterocyclic compound binding#GO:1901363;monoatomic ion transmembrane transporter activity#GO:0015075;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;ligase activity#GO:0016874;ribonucleotide binding#GO:0032553;channel activity#GO:0015267;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;monoatomic cation channel activity#GO:0005261;nucleotide binding#GO:0000166;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;transmembrane transporter activity#GO:0022857 phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP biosynthetic process#GO:0006754;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;organophosphate biosynthetic process#GO:0090407;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate biosynthetic process#GO:1901293 respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;proton-transporting ATP synthase complex#GO:0045259;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;catalytic complex#GO:1902494;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 primary active transporter#PC00068;ATP synthase#PC00002 ATP synthesis#P02721>F1 alpha#P02791 HELRO|EnsemblGenome=HelroG63267|UniProtKB=T1FXD1 T1FXD1 20213479 PTHR11208:SF42 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG174563|UniProtKB=T1F893 T1F893 20205042 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG173392|UniProtKB=T1F6R8 T1F6R8 20204517 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG194011|UniProtKB=T1FVK5 T1FVK5 20212851 PTHR11699:SF302 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 metabolic process#GO:0008152;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;catabolic process#GO:0009056;aldehyde catabolic process#GO:0046185 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG106488|UniProtKB=T1EE29 T1EE29 20194831 PTHR45679:SF5 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1 biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG163202|UniProtKB=T1ETS6 T1ETS6 20199976 PTHR19372:SF7 SULFITE REDUCTASE SULFITE OXIDASE, MITOCHONDRIAL mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG173329|UniProtKB=T1F6P3 T1F6P3 20204492 PTHR13578:SF20 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB GROUP PROTEIN ASX binding#GO:0005488;chromatin binding#GO:0003682 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;PcG protein complex#GO:0031519;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG80463|UniProtKB=T1G412 T1G412 20215810 PTHR11406:SF0 PHOSPHOGLYCERATE KINASE PHOSPHOGLYCERATE KINASE purine nucleotide binding#GO:0017076;transferase activity#GO:0016740;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;kinase activity#GO:0016301;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;phosphotransferase activity, carboxyl group as acceptor#GO:0016774;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;phosphoglycerate kinase activity#GO:0004618 ADP catabolic process#GO:0046032;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;monocarboxylic acid metabolic process#GO:0032787;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;pyruvate metabolic process#GO:0006090;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate catabolic process#GO:1901292;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;gluconeogenesis#GO:0006094;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;ribonucleoside diphosphate metabolic process#GO:0009185;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;nucleotide catabolic process#GO:0009166;small molecule biosynthetic process#GO:0044283;energy derivation by oxidation of organic compounds#GO:0015980;nucleobase-containing compound catabolic process#GO:0034655;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;nucleoside diphosphate catabolic process#GO:0009134;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphoglycerate kinase#P00671 HELRO|EnsemblGenome=HelroG150157|UniProtKB=T1EKE5 T1EKE5 20197045 PTHR46006:SF6 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A DH DOMAIN-CONTAINING PROTEIN positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG155224|UniProtKB=T1ELH7 T1ELH7 20197427 PTHR12682:SF11 ARCHEASE TRNA-SPLICING LIGASE-ACTIVATING FACTOR ARCHEASE protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG174842|UniProtKB=T1F8J2 T1F8J2 20205141 PTHR31395:SF26 SHISA GEO05642P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194783|UniProtKB=T1FWE7 T1FWE7 20213142 PTHR13170:SF16 O-GLCNACASE PROTEIN O-GLCNACASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG169995|UniProtKB=T1F2I3 T1F2I3 20203033 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG193617|UniProtKB=T1FV67 T1FV67 20212713 PTHR11804:SF86 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED LD37516P metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG182439|UniProtKB=T1FI72 T1FI72 20208521 PTHR25462:SF295 BONUS, ISOFORM C-RELATED B BOX-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG172179|UniProtKB=T1F547 T1F547 20203946 PTHR15544:SF0 OSMOSIS RESPONSIVE FACTOR TETRATRICOPEPTIDE REPEAT PROTEIN 33 HELRO|EnsemblGenome=HelroG174887|UniProtKB=T1F8K8 T1F8K8 20205157 PTHR24067:SF3 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 G1 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG167612|UniProtKB=T1EZK1 T1EZK1 20202001 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG102959|UniProtKB=T1EDD4 T1EDD4 20194586 PTHR10805:SF0 COATOMER SUBUNIT EPSILON COATOMER SUBUNIT EPSILON transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;COPI-coated vesicle#GO:0030137;membrane#GO:0016020;vesicle membrane#GO:0012506 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG185454|UniProtKB=T1FMU4 T1FMU4 20210143 PTHR10138:SF0 TRYPTOPHAN 2,3-DIOXYGENASE TRYPTOPHAN 2,3-DIOXYGENASE dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824;binding#GO:0005488;heme binding#GO:0020037 amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG194731|UniProtKB=T1FWC9 T1FWC9 20213124 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of gene expression#GO:0010629;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biological process#GO:0048519;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105454|UniProtKB=T1EDU9 T1EDU9 20194751 PTHR16166:SF141 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13 INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014;transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;transport#GO:0006810;lipid transport#GO:0006869;macroautophagy#GO:0016236;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;autophagy#GO:0006914;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;lipid localization#GO:0010876;catabolic process#GO:0009056;cellular component organization#GO:0016043 membrane#GO:0016020;vesicle membrane#GO:0012506;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;mitochondrion#GO:0005739;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;outer membrane#GO:0019867;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG116974|UniProtKB=T1EGJ0 T1EGJ0 20195692 PTHR10859:SF91 GLYCOSYL TRANSFERASE DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG159991|UniProtKB=T1EPM6 T1EPM6 20198526 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104422|UniProtKB=T1EDL6 T1EDL6 20194668 PTHR43000:SF54 DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED UDP-D-GLUCOSE 4,6-DEHYDRATASE catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 dehydratase#PC00091 O-antigen biosynthesis#P02757>dTDP-glucose 4,6-dehydratase#P03045 HELRO|EnsemblGenome=HelroG194306|UniProtKB=T1FVW9 T1FVW9 20212965 PTHR13453:SF1 KAT8 REGULATORY NSL COMPLEX SUBUNIT 2 KAT8 REGULATORY NSL COMPLEX SUBUNIT 2 chromatin#GO:0000785;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;NSL complex#GO:0044545;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189739|UniProtKB=T1FRB7 T1FRB7 20211364 PTHR46040:SF3 HIGH MOBILITY GROUP PROTEIN 2 HIGH MOBILITY GROUP PROTEIN 2 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG187315|UniProtKB=T1FP87 T1FP87 20210634 PTHR13780:SF166 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166;cation binding#GO:0043169;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 regulation of metabolic process#GO:0019222;response to stress#GO:0006950;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of carbohydrate metabolic process#GO:0006109;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of carbohydrate biosynthetic process#GO:0043255;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG175667|UniProtKB=T1F9H8 T1F9H8 20205477 PTHR28495:SF2 HYPOTHETICAL PROTEIN LOC100359752 DUF4708 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192040|UniProtKB=T1FTJ2 T1FTJ2 20212139 PTHR11923:SF117 SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1 SENSORY NEURON MEMBRANE PROTEIN 2 cargo receptor activity#GO:0038024 cellular anatomical structure#GO:0110165;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG174987|UniProtKB=T1F8P5 T1F8P5 20205194 PTHR45834:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG68567|UniProtKB=T1FZG7 T1FZG7 20214215 PTHR43109:SF2 NUCLEOSIDE DIPHOSPHATE KINASE 7 NUCLEOSIDE DIPHOSPHATE KINASE 7 cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule#GO:0005874;axoneme#GO:0005930;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 transferase#PC00220;kinase#PC00137 De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo purine biosynthesis#P02738>dADP kinase#P02907 HELRO|EnsemblGenome=HelroG193365|UniProtKB=T1FUX1 T1FUX1 20212617 PTHR25464:SF5 TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RING1A-RELATED cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;response to nutrient levels#GO:0031667;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular response to amino acid starvation#GO:0034198;biological regulation#GO:0065007;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;regulation of autophagy#GO:0010506;response to starvation#GO:0042594;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 HELRO|EnsemblGenome=HelroG82648|UniProtKB=T1G4U7 T1G4U7 20216095 PTHR24351:SF289 RIBOSOMAL PROTEIN S6 KINASE CHROMOSOMAL SERINE_THREONINE-PROTEIN KINASE JIL-1 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;TORC1 signaling#GO:0038202;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;TOR signaling#GO:0031929;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HELRO|EnsemblGenome=HelroG187011|UniProtKB=T1FP56 T1FP56 20210603 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;carbohydrate transmembrane transport#GO:0034219;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;carbohydrate transport#GO:0008643;transport#GO:0006810;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG181150|UniProtKB=T1FGP1 T1FGP1 20207990 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG117121|UniProtKB=T1EGK4 T1EGK4 20195705 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular process#GO:0009987;potassium ion transport#GO:0006813;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG104527|UniProtKB=T1EDM1 T1EDM1 20194673 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FI18312P1 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG165250|UniProtKB=T1EWH9 T1EWH9 20200929 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG178720|UniProtKB=T1FDM6 T1FDM6 20206925 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71941|UniProtKB=T1G0T1 T1G0T1 20214679 PTHR15460:SF3 PEROXISOMAL MEMBRANE PROTEIN 4 PEROXISOMAL MEMBRANE PROTEIN 4 microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG98250|UniProtKB=T1G9L3 T1G9L3 20217759 PTHR14212:SF0 U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;organelle#GO:0043226 RNA splicing factor#PC00148 mRNA splicing#P00058>U6#P01473;mRNA splicing#P00058>U4#P01476 HELRO|EnsemblGenome=HelroG150642|UniProtKB=T1EKG7 T1EKG7 20197067 PTHR45617:SF169 LEUCINE RICH REPEAT FAMILY PROTEIN LP04042P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172281|UniProtKB=T1F564 T1F564 20203963 PTHR28457:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 189 SIMILAR TO HUMAN CHROMOSOME 8 OPEN READING FRAME 74 HELRO|EnsemblGenome=HelroG67950|UniProtKB=T1FZ83 T1FZ83 20214131 PTHR24072:SF398 RHO FAMILY GTPASE RAS-LIKE GTP-BINDING PROTEIN RHO1 enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;protein binding#GO:0005515;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cell migration#GO:0016477 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208;G-protein#PC00020 Ras Pathway#P04393>Rho#P04578;Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Integrin signalling pathway#P00034>Rho#P00948;Angiogenesis#P00005>GTPase#P00254;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507 HELRO|EnsemblGenome=HelroG112004|UniProtKB=T1EFG3 T1EFG3 20195315 PTHR15591:SF19 RUN AND SH3 DOMAIN CONTAINING RUN DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG87923|UniProtKB=T1G6X0 T1G6X0 20216817 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191180|UniProtKB=T1FSP9 T1FSP9 20211846 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;cytoskeletal protein binding#GO:0008092;enzyme activator activity#GO:0008047;SNARE binding#GO:0000149;myosin binding#GO:0017022;syntaxin binding#GO:0019905;molecular function activator activity#GO:0140677;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;binding#GO:0005488 regulation of signaling#GO:0023051;establishment or maintenance of cell polarity#GO:0007163;post-Golgi vesicle-mediated transport#GO:0006892;secretion by cell#GO:0032940;spindle localization#GO:0051653;cellular localization#GO:0051641;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cellular component organization#GO:0016043;export from cell#GO:0140352;establishment of organelle localization#GO:0051656;Golgi vesicle transport#GO:0048193;exocytosis#GO:0006887;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192;regulation of establishment or maintenance of cell polarity#GO:0032878;localization within membrane#GO:0051668;regulation of Notch signaling pathway#GO:0008593;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;organelle localization#GO:0051640;cortical actin cytoskeleton organization#GO:0030866;localization#GO:0051179;secretion#GO:0046903;microtubule cytoskeleton organization#GO:0000226;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049;regulation of cell communication#GO:0010646;Golgi to plasma membrane transport#GO:0006893;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of response to stimulus#GO:0048583;transport#GO:0006810;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;establishment of spindle localization#GO:0051293;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;membrane#GO:0016020;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG168356|UniProtKB=T1F0G5 T1F0G5 20202315 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158200|UniProtKB=T1EMK3 T1EMK3 20197803 PTHR43286:SF7 ENDONUCLEASE III-LIKE PROTEIN 1 ENDONUCLEASE III-LIKE PROTEIN 1 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;DNA N-glycosylase activity#GO:0019104;endonuclease activity#GO:0004519;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 response to stimulus#GO:0050896;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA glycosylase#PC00010;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG112113|UniProtKB=T1EFH1 T1EFH1 20195323 PTHR12195:SF6 CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED CYTOPLASMIC FMR1-INTERACTING PROTEIN axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;regulation of protein metabolic process#GO:0051246;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;post-transcriptional regulation of gene expression#GO:0010608;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon guidance#GO:0007411;axon development#GO:0061564;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090 plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG67273|UniProtKB=T1FYZ2 T1FYZ2 20214040 PTHR28572:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 103 DYNEIN AXONEMAL ASSEMBLY FACTOR 19 pattern specification process#GO:0007389;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;determination of left/right symmetry#GO:0007368;developmental process#GO:0032502;specification of symmetry#GO:0009799;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;regionalization#GO:0003002;inner dynein arm assembly#GO:0036159;cilium organization#GO:0044782;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;left/right pattern formation#GO:0060972;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;determination of bilateral symmetry#GO:0009855;cellular component assembly#GO:0022607 HELRO|EnsemblGenome=HelroG175852|UniProtKB=T1F9S1 T1F9S1 20205570 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164129|UniProtKB=T1EUZ3 T1EUZ3 20200393 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189609|UniProtKB=T1FR72 T1FR72 20211319 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166113|UniProtKB=T1EXS5 T1EXS5 20201375 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG164358|UniProtKB=T1EVB4 T1EVB4 20200514 PTHR14440:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 cellular component biogenesis#GO:0044085;transcription by RNA polymerase I#GO:0006360;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;transcription initiation at RNA polymerase I promoter#GO:0006361;protein-containing complex organization#GO:0043933;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG182425|UniProtKB=T1FI63 T1FI63 20208512 PTHR11363:SF5 60S RIBOSOMAL PROTEIN L3-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL3 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 translational protein#PC00263;ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG166571|UniProtKB=T1EY95 T1EY95 20201545 PTHR13101:SF1 PHOSPHOMEVALONATE KINASE PHOSPHOMEVALONATE KINASE phosphotransferase activity, phosphate group as acceptor#GO:0016776;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;isoprenoid biosynthetic process#GO:0008299;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;cholesterol biosynthetic process#GO:0006695;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;sulfur compound metabolic process#GO:0006790;nucleobase-containing small molecule metabolic process#GO:0055086;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;isoprenoid metabolic process#GO:0006720;acetyl-CoA metabolic process#GO:0006084;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;lipid biosynthetic process#GO:0008610;organophosphate metabolic process#GO:0019637;acyl-CoA metabolic process#GO:0006637;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Phosphomevalonate kinase#P00500 HELRO|EnsemblGenome=HelroG194253|UniProtKB=T1FVV3 T1FVV3 20212949 PTHR21448:SF0 SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21 vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG133632|UniProtKB=T1EI18 T1EI18 20196218 PTHR19300:SF30 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 7 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG180635|UniProtKB=T1FG39 T1FG39 20207788 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG181023|UniProtKB=T1FGJ5 T1FGJ5 20207944 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG74949|UniProtKB=T1G1Y2 T1G1Y2 20215080 PTHR47961:SF12 DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED HELICASE POLQ-LIKE ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097 double-strand break repair#GO:0006302;DNA double-strand break processing#GO:0000729;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;double-strand break repair via single-strand annealing#GO:0045002;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG79114|UniProtKB=T1G3K3 T1G3K3 20215651 PTHR46337:SF1 RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrial fusion#GO:0008053;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;ribonucleoprotein complex biogenesis#GO:0022613;mitochondrion organization#GO:0007005;ribosome biogenesis#GO:0042254;organelle assembly#GO:0070925;ribosome assembly#GO:0042255;cellular component organization or biogenesis#GO:0071840;mitochondrial ribosome assembly#GO:0061668 membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG170285|UniProtKB=T1F2V7 T1F2V7 20203156 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG159270|UniProtKB=T1ENT2 T1ENT2 20198232 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG185836|UniProtKB=T1FNC7 T1FNC7 20210324 PTHR10003:SF71 SUPEROXIDE DISMUTASE CU-ZN -RELATED EXTRACELLULAR SUPEROXIDE DISMUTASE [CU-ZN]-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;copper ion binding#GO:0005507;antioxidant activity#GO:0016209;metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914 cellular detoxification#GO:1990748;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to stimulus#GO:0051716;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;superoxide metabolic process#GO:0006801;cellular response to chemical stress#GO:0062197;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular oxidant detoxification#GO:0098869;response to stress#GO:0006950;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194514|UniProtKB=T1FW52 T1FW52 20213048 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77349|UniProtKB=T1G2W7 T1G2W7 20215415 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG86301|UniProtKB=T1G6A1 T1G6A1 20216598 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE GLYCOPROTEIN 3-ALPHA-L-FUCOSYLTRANSFERASE A fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;alpha-(1->3)-fucosyltransferase activity#GO:0046920;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG184881|UniProtKB=T1FM46 T1FM46 20209895 PTHR12780:SF1 RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG163175|UniProtKB=T1ETR3 T1ETR3 20199963 PTHR46464:SF2 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN-LIKE HELRO|EnsemblGenome=HelroG107993|UniProtKB=T1EEE6 T1EEE6 20194948 PTHR12270:SF25 GLYCOSYLTRANSFERASE-RELATED GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE xylosyltransferase activity#GO:0042285;glucuronosyltransferase activity#GO:0015020;pentosyltransferase activity#GO:0016763;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG74707|UniProtKB=T1G1U7 T1G1U7 20215045 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG194225|UniProtKB=T1FVU1 T1FVU1 20212937 PTHR10791:SF112 RAG1-ACTIVATING PROTEIN 1 SUGAR TRANSPORTER SWEET1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119 localization#GO:0051179;establishment of localization#GO:0051234;carbohydrate transport#GO:0008643;transport#GO:0006810 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG76698|UniProtKB=T1G2M7 T1G2M7 20215325 PTHR43115:SF4 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185461|UniProtKB=T1FMU6 T1FMU6 20210145 PTHR24056:SF598 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472 cellular process#GO:0009987;signal transduction#GO:0007165;cell cycle G2/M phase transition#GO:0044839;biological regulation#GO:0065007;mitotic cell cycle process#GO:1903047;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell cycle#GO:0007049;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;mitotic cell cycle phase transition#GO:0044772;cell communication#GO:0007154 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625;p53 pathway#P00059>Cdc2#P04634 HELRO|EnsemblGenome=HelroG81131|UniProtKB=T1G499 T1G499 20215897 PTHR11254:SF445 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE HECT-TYPE E3 UBIQUITIN TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG181813|UniProtKB=T1FHD2 T1FHD2 20208231 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG84403|UniProtKB=T1G5I4 T1G5I4 20216331 PTHR11999:SF70 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE MIP05841P lyase#PC00144;decarboxylase#PC00089 Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066;5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961 HELRO|EnsemblGenome=HelroG185075|UniProtKB=T1FMD2 T1FMD2 20209981 PTHR11937:SF607 ACTIN ACTIN-42A-RELATED structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cell cycle process#GO:0022402;cell division#GO:0051301;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG171671|UniProtKB=T1F4J2 T1F4J2 20203741 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177713|UniProtKB=T1FC45 T1FC45 20206394 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG177300|UniProtKB=T1FBH2 T1FBH2 20206171 PTHR23011:SF28 CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77660|UniProtKB=T1G317 T1G317 20215465 PTHR14237:SF96 MOLYBDOPTERIN COFACTOR SULFURASE MOSC MOLYBDENUM COFACTOR SULFURASE transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782 cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG105953|UniProtKB=T1EDY8 T1EDY8 20194790 PTHR11915:SF447 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG187704|UniProtKB=T1FPC1 T1FPC1 20210668 PTHR12929:SF10 SOLUTE CARRIER FAMILY 52 RIBOFLAVIN TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG174618|UniProtKB=T1F8A9 T1F8A9 20205058 PTHR15341:SF3 SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;DNA binding#GO:0003677 cellular component biogenesis#GO:0044085;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG184454|UniProtKB=T1FL85 T1FL85 20209584 PTHR12400:SF21 INOSITOL POLYPHOSPHATE KINASE KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 organophosphate biosynthetic process#GO:0090407;small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637 kinase#PC00137 HELRO|EnsemblGenome=HelroG185440|UniProtKB=T1FMT9 T1FMT9 20210138 PTHR12299:SF17 HYALURONIC ACID-BINDING PROTEIN 4 AT19571P-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177786|UniProtKB=T1FC96 T1FC96 20206445 PTHR10281:SF106 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED IP06960P-RELATED intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG85626|UniProtKB=T1G608 T1G608 20216505 PTHR11064:SF9 CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 Gonadotropin-releasing hormone receptor pathway#P06664>NF-Y#P06742 HELRO|EnsemblGenome=HelroG194924|UniProtKB=T1FWK6 T1FWK6 20213201 PTHR12300:SF197 HVA22-LIKE PROTEINS LP05237P-RELATED microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 organelle organization#GO:0006996;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum tubular network organization#GO:0071786;endomembrane system organization#GO:0010256 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;endoplasmic reticulum tubular network#GO:0071782;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;endoplasmic reticulum#GO:0005783;cytoskeleton#GO:0005856;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic microtubule#GO:0005881;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG161002|UniProtKB=T1EQZ7 T1EQZ7 20198997 PTHR14226:SF79 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 7 phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;hydrolase activity#GO:0016787 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161542|UniProtKB=T1ERL7 T1ERL7 20199217 PTHR42790:SF24 AMINOTRANSFERASE KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL transaminase activity#GO:0008483;catalytic activity#GO:0003824;transferase activity#GO:0016740 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transaminase#PC00216 HELRO|EnsemblGenome=HelroG80203|UniProtKB=T1G3Y7 T1G3Y7 20215785 PTHR24349:SF561 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 2 kinase activity#GO:0016301;transferase activity#GO:0016740;calmodulin binding#GO:0005516;mitogen-activated protein kinase binding#GO:0051019;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;calcium/calmodulin-dependent protein kinase activity#GO:0004683;binding#GO:0005488;kinase binding#GO:0019900;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Angiogenesis#P00005>MAPKAPK2/3#P00244;Ras Pathway#P04393>MAPKAP#P04564;VEGF signaling pathway#P00056>MAPKAPK2/3#P01415;PDGF signaling pathway#P00047>MAPKAPK2#P01157 HELRO|EnsemblGenome=HelroG164224|UniProtKB=T1FKU0 T1FKU0 20200444 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189398|UniProtKB=T1FR08 T1FR08 20211255 PTHR46117:SF3 FI24210P1 FI24210P1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG179098|UniProtKB=T1FE57 T1FE57 20207106 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG169408|UniProtKB=T1F1W7 T1F1W7 20202817 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164499|UniProtKB=T1EVI4 T1EVI4 20200584 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG175642|UniProtKB=T1F9G5 T1F9G5 20205464 PTHR24416:SF620 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR TORSO transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG89851|UniProtKB=T1G7I3 T1G7I3 20217030 PTHR13533:SF1 N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE LD22456P acetyltransferase#PC00038;transferase#PC00220 HELRO|EnsemblGenome=HelroG121441|UniProtKB=T1EGS1 T1EGS1 20195771 PTHR22957:SF26 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN LD44506P molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG68926|UniProtKB=T1FZL9 T1FZL9 20214267 PTHR12595:SF0 POS9-ACTIVATING FACTOR FAP7-RELATED ADENYLATE KINASE ISOENZYME 6 nucleotide binding#GO:0000166;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;transferase activity#GO:0016740;purine nucleotide binding#GO:0017076;kinase activity#GO:0016301;ribonucleotide binding#GO:0032553;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;nucleobase-containing compound kinase activity#GO:0019205;ATP binding#GO:0005524 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG158358|UniProtKB=T1EMP5 T1EMP5 20197845 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG145322|UniProtKB=T1EJK1 T1EJK1 20196751 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164889|UniProtKB=T1EVX3 T1EVX3 20200723 PTHR34718:SF3 PHD-TYPE DOMAIN-CONTAINING PROTEIN UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165532|UniProtKB=T1EWZ1 T1EWZ1 20201091 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG162766|UniProtKB=T1ET39 T1ET39 20199739 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG159093|UniProtKB=T1ENK8 T1ENK8 20198158 PTHR33748:SF5 PROTEIN CBG04600 GROUND-LIKE DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG87401|UniProtKB=T1G6P6 T1G6P6 20216743 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG183584|UniProtKB=T1FJV7 T1FJV7 20209106 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG177644|UniProtKB=T1FC00 T1FC00 20206349 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG133378|UniProtKB=T1EI06 T1EI06 20196206 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG124593|UniProtKB=T1EH20 T1EH20 20195870 PTHR22966:SF76 2-AMINOETHANETHIOL DIOXYGENASE 2-AMINOETHANETHIOL DIOXYGENASE oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;response to hypoxia#GO:0001666;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;response to abiotic stimulus#GO:0009628;cellular response to hypoxia#GO:0071456;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;response to chemical#GO:0042221;response to stimulus#GO:0050896 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG169996|UniProtKB=T1F2I4 T1F2I4 20203034 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65558|UniProtKB=T1FY97 T1FY97 20213795 PTHR11599:SF5 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-4 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;proteasome complex#GO:0000502;nucleus#GO:0005634;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG64595|UniProtKB=T1FXW8 T1FXW8 20213666 PTHR12210:SF3 DULLARD PROTEIN PHOSPHATASE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721 intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;mitochondrial transmembrane transport#GO:1990542;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;protein localization to mitochondrion#GO:0070585 organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG162466|UniProtKB=T1ESP8 T1ESP8 20199598 PTHR45638:SF25 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;guanyl ribonucleotide binding#GO:0032561;monoatomic cation transmembrane transporter activity#GO:0008324;guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;monoatomic ion channel activity#GO:0005216;purine ribonucleotide binding#GO:0032555;monoatomic ion transmembrane transporter activity#GO:0015075;heterocyclic compound binding#GO:1901363;transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076 cellular process#GO:0009987;multicellular organismal process#GO:0032501;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;transport#GO:0006810;nervous system process#GO:0050877;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;system process#GO:0003008;monoatomic ion transport#GO:0006811 cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702 ligand-gated ion channel#PC00141;ion channel#PC00133 HELRO|EnsemblGenome=HelroG95909|UniProtKB=T1G988 T1G988 20217635 PTHR42698:SF1 GTPASE ERA GTPASE ERA, MITOCHONDRIAL cellular component assembly#GO:0022607;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;ribosomal small subunit assembly#GO:0000028;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;ribosomal small subunit biogenesis#GO:0042274;ribonucleoprotein complex biogenesis#GO:0022613;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein-RNA complex assembly#GO:0022618;ribosome biogenesis#GO:0042254;organelle assembly#GO:0070925;ribosome assembly#GO:0042255 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184679|UniProtKB=T1FLR2 T1FLR2 20209761 PTHR28643:SF1 SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 response to stimulus#GO:0050896;regulation of biological process#GO:0050789;double-strand break repair via homologous recombination#GO:0000724;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular response to stress#GO:0033554;positive regulation of macromolecule metabolic process#GO:0010604;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;recombinational repair#GO:0000725;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;DNA repair#GO:0006281;DNA damage response#GO:0006974 organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG92870|UniProtKB=T1G8M6 T1G8M6 20217423 PTHR11410:SF0 ATP SYNTHASE SUBUNIT A ATP SYNTHASE F(0) COMPLEX SUBUNIT A proton channel activity#GO:0015252;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933 organophosphate biosynthetic process#GO:0090407;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;ATP biosynthetic process#GO:0006754;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;proton-transporting two-sector ATPase complex#GO:0016469;catalytic complex#GO:1902494;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;proton-transporting ATP synthase complex#GO:0045259;respiratory chain complex#GO:0098803;membrane#GO:0016020;membrane protein complex#GO:0098796 primary active transporter#PC00068;ATP synthase#PC00002 ATP synthesis#P02721>ATP synthetase F0#P02797 HELRO|EnsemblGenome=HelroG166585|UniProtKB=T1EYA0 T1EYA0 20201550 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG103005|UniProtKB=T1EDD6 T1EDD6 20194588 PTHR10841:SF17 SYNAPSIN SYNAPSIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;presynapse#GO:0098793;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 Synaptic vesicle trafficking#P05734>Synapsin#P05775 HELRO|EnsemblGenome=HelroG142702|UniProtKB=T1EJ69 T1EJ69 20196619 PTHR10231:SF109 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 transporter#PC00227 HELRO|EnsemblGenome=HelroG193795|UniProtKB=T1FVD0 T1FVD0 20212776 PTHR13159:SF0 RADIAL SPOKEHEAD-RELATED RADIAL SPOKE HEAD COMPONENT 4A microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;axoneme assembly#GO:0035082;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium assembly#GO:0060271;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG174420|UniProtKB=T1F839 T1F839 20204988 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90647|UniProtKB=T1G7T8 T1G7T8 20217135 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;neuron fate commitment#GO:0048663;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell fate specification#GO:0001708;positive regulation of transcription by RNA polymerase II#GO:0045944;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG86343|UniProtKB=T1G6A8 T1G6A8 20216605 PTHR34929:SF5 ZGC:153157 TRANSMEMBRANE PROTEIN INAFM2 HELRO|EnsemblGenome=HelroG162084|UniProtKB=T1ES84 T1ES84 20199434 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG86568|UniProtKB=T1G6E0 T1G6E0 20216637 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG167292|UniProtKB=T1EZ81 T1EZ81 20201881 PTHR48225:SF7 HORMA DOMAIN-CONTAINING PROTEIN 1 MEIOSIS-SPECIFIC PROTEIN HOP1 nuclear division#GO:0000280;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;negative regulation of cell cycle#GO:0045786;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;regulation of cell cycle process#GO:0010564;homologous chromosome pairing at meiosis#GO:0007129;cell cycle checkpoint signaling#GO:0000075;cellular component assembly#GO:0022607;synaptonemal complex assembly#GO:0007130;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organelle fission#GO:0048285;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;meiotic nuclear division#GO:0140013;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;regulation of reproductive process#GO:2000241 organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086;condensed chromosome#GO:0000793;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG159191|UniProtKB=T1ENQ3 T1ENQ3 20198203 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG112163|UniProtKB=T1EFH5 T1EFH5 20195327 PTHR12899:SF23 39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M nucleic acid binding#GO:0003676;binding#GO:0005488;rRNA binding#GO:0019843;RNA binding#GO:0003723 RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;nucleic acid transport#GO:0050657;localization#GO:0051179;transport#GO:0006810 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG81357|UniProtKB=T1G4D6 T1G4D6 20215934 PTHR14920:SF0 OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN WD REPEAT DOMAIN 19 plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;intraciliary transport#GO:0042073;intraciliary retrograde transport#GO:0035721;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intraciliary transport particle A#GO:0030991;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG182208|UniProtKB=T1FHX5 T1FHX5 20208424 PTHR15208:SF2 RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141 HELRO|EnsemblGenome=HelroG66878|UniProtKB=T1FYS3 T1FYS3 20213971 PTHR47046:SF1 SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex II assembly#GO:0034553;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG160718|UniProtKB=T1EQM9 T1EQM9 20198879 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;protein localization to plasma membrane#GO:0072659;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG103893|UniProtKB=T1EDI2 T1EDI2 20194634 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER TONOPLAST DICARBOXYLATE TRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG186418|UniProtKB=T1FNZ4 T1FNZ4 20210541 PTHR15735:SF12 FCH AND DOUBLE SH3 DOMAINS PROTEIN CDC42-INTERACTING PROTEIN 4, ISOFORM B regulation of organelle organization#GO:0033043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of actin cytoskeleton organization#GO:0032956;membrane organization#GO:0061024;biological regulation#GO:0065007;endomembrane system organization#GO:0010256;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG127865|UniProtKB=T1EHJ0 T1EHJ0 20196040 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG78584|UniProtKB=T1G3D3 T1G3D3 20215581 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG185810|UniProtKB=T1FNB6 T1FNB6 20210313 PTHR10827:SF52 RETICULOCALBIN RETICULOCALBIN-3 calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG155569|UniProtKB=T1ELI9 T1ELI9 20197439 PTHR24347:SF458 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG70670|UniProtKB=T1G0A4 T1G0A4 20214502 PTHR12596:SF2 EXPORTIN 4,7-RELATED EXPORTIN-7 ISOFORM X1 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein export from nucleus#GO:0006611;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HELRO|EnsemblGenome=HelroG177795|UniProtKB=T1FCA1 T1FCA1 20206450 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG106870|UniProtKB=T1EE54 T1EE54 20194856 PTHR23050:SF547 CALCIUM BINDING PROTEIN AT10229P-RELATED calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG163135|UniProtKB=T1ETP6 T1ETP6 20199946 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173827|UniProtKB=T1F7A5 T1F7A5 20204704 PTHR45749:SF23 ZINC FINGER MYM-TYPE PROTEIN 1 ZINC FINGER MYM-TYPE PROTEIN 1 ISOFORM X1 HELRO|EnsemblGenome=HelroG187204|UniProtKB=T1FP76 T1FP76 20210623 PTHR11109:SF7 GTP CYCLOHYDROLASE I GTP CYCLOHYDROLASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824 pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Tetrahydrofolate biosynthesis#P02742>GTP cyclohydrolase#P02951 HELRO|EnsemblGenome=HelroG169447|UniProtKB=T1F1Y0 T1F1Y0 20202830 PTHR14716:SF2 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69 ARM REPEATS DOMAIN-CONTAINING PROTEIN regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of reproductive process#GO:2000241;regulation of microtubule-based movement#GO:0060632;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell motility#GO:2000147;positive regulation of locomotion#GO:0040017;regulation of cell motility#GO:2000145;regulation of microtubule-based process#GO:0032886 cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;non-motile cilium#GO:0097730;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227 structural protein#PC00211 HELRO|EnsemblGenome=HelroG184904|UniProtKB=T1FM55 T1FM55 20209904 PTHR19305:SF42 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN 29 protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;binding#GO:0005488;syntaxin binding#GO:0019905;SNAP receptor activity#GO:0005484;protein binding#GO:0005515 secretion by cell#GO:0032940;secretion#GO:0046903;localization#GO:0051179;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;export from cell#GO:0140352;transport#GO:0006810;vesicle organization#GO:0016050;exocytosis#GO:0006887;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284 plasma membrane#GO:0005886;cytoplasm#GO:0005737;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049 HELRO|EnsemblGenome=HelroG97508|UniProtKB=T1G9H5 T1G9H5 20217722 PTHR12131:SF31 ATP-DEPENDENT RNA AND DNA HELICASE ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitochondrial gene expression#GO:0140053;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;nucleic acid biosynthetic process#GO:0141187;mitochondrial RNA 3'-end processing#GO:0000965;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;mitochondrial RNA processing#GO:0000963;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG176214|UniProtKB=T1FAA9 T1FAA9 20205758 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG69274|UniProtKB=T1FZS7 T1FZS7 20214325 PTHR13047:SF0 PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 5 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG173311|UniProtKB=T1F6N7 T1F6N7 20204486 PTHR35261:SF3 ORGANELLAR PROTEIN, PUTATIVE-RELATED-RELATED VACUOLAR IMPORT AND DEGRADATION PROTEIN 22 HELRO|EnsemblGenome=HelroG107666|UniProtKB=T1EEC1 T1EEC1 20194923 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG185417|UniProtKB=T1FMS7 T1FMS7 20210126 PTHR11040:SF223 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 cellular process#GO:0009987;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG167749|UniProtKB=T1EZR1 T1EZR1 20202061 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN CC8L18.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG173116|UniProtKB=T1F6E0 T1F6E0 20204389 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172361|UniProtKB=T1F582 T1F582 20203981 PTHR19960:SF11 TEKTIN LD08455P cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG160844|UniProtKB=T1EQT4 T1EQT4 20198934 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED transition metal ion binding#GO:0046914;ion binding#GO:0043167;zinc ion binding#GO:0008270;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73673|UniProtKB=T1G1H1 T1G1H1 20214919 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG108687|UniProtKB=T1EEL5 T1EEL5 20195017 PTHR12175:SF7 AD039 HT014 THIOREDOXIN FAMILY TRP26 PITH DOMAIN-CONTAINING PROTEIN 1 regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of developmental process#GO:0051094;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of cell development#GO:0060284;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of myeloid cell differentiation#GO:0045639;regulation of hemopoiesis#GO:1903706;regulation of myeloid cell differentiation#GO:0045637;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG71249|UniProtKB=T1G0I4 T1G0I4 20214582 PTHR11616:SF340 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;glycine transmembrane transporter activity#GO:0015187;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039;metal ion transport#GO:0030001;glycine transport#GO:0015816;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG107370|UniProtKB=T1EEA1 T1EEA1 20194903 PTHR12726:SF0 CERAMIDE GLUCOSYLTRANSFERASE CERAMIDE GLUCOSYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;glucosyltransferase activity#GO:0046527 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;carbohydrate derivative biosynthetic process#GO:1901137;primary metabolic process#GO:0044238;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;glycosphingolipid biosynthetic process#GO:0006688;glycolipid biosynthetic process#GO:0009247;ceramide metabolic process#GO:0006672 cellular anatomical structure#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG159246|UniProtKB=T1ENS8 T1ENS8 20198228 PTHR21522:SF32 PROTON CHANNEL OTOP PROTON CHANNEL OTOPLC proton channel activity#GO:0015252;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG170910|UniProtKB=T1F3L1 T1F3L1 20203410 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 response to stimulus#GO:0050896;response to stress#GO:0006950;response to nutrient levels#GO:0031667;response to starvation#GO:0042594 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG157537|UniProtKB=T1EMC8 T1EMC8 20197728 PTHR13481:SF0 SREBP REGULATING GENE PROTEIN SREBP REGULATING GENE PROTEIN HELRO|EnsemblGenome=HelroG171152|UniProtKB=T1F3V5 T1F3V5 20203504 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription coregulator activity#GO:0003712;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367 transferase complex#GO:1990234;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG138706|UniProtKB=T1EIW8 T1EIW8 20196518 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;sensory organ development#GO:0007423;developmental process#GO:0032502 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG192304|UniProtKB=T1FTT3 T1FTT3 20212230 PTHR23119:SF44 DISCS LARGE PROTEIN LAP4 protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 endosome to plasma membrane protein transport#GO:0099638;macromolecule localization#GO:0033036;biological regulation#GO:0065007;transport#GO:0006810;intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;protein localization to plasma membrane#GO:0072659;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cell-cell adhesion#GO:0098609;establishment of protein localization to membrane#GO:0090150;vesicle-mediated transport#GO:0016192;intracellular protein transport#GO:0006886;protein localization to cell periphery#GO:1990778;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;endosomal transport#GO:0016197;protein localization to synapse#GO:0035418;protein localization to membrane#GO:0072657;endocytic recycling#GO:0032456;receptor clustering#GO:0043113;cell adhesion#GO:0007155;establishment or maintenance of cell polarity#GO:0007163;protein transport#GO:0015031;regulation of biological quality#GO:0065008;cellular localization#GO:0051641 postsynapse#GO:0098794;basal part of cell#GO:0045178;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;adherens junction#GO:0005912 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171680|UniProtKB=T1F4J6 T1F4J6 20203745 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85555|UniProtKB=T1G5Z1 T1G5Z1 20216488 PTHR23074:SF173 AAA DOMAIN-CONTAINING SPASTIN ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;polypeptide conformation or assembly isomerase activity#GO:0120544 nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;central nervous system neuron differentiation#GO:0021953;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;system development#GO:0048731 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG94851|UniProtKB=T1G935 T1G935 20217582 PTHR13710:SF108 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q4 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG167320|UniProtKB=T1EZ92 T1EZ92 20201892 PTHR23186:SF4 RETINOIC ACID-INDUCED PROTEIN 2 GH22790P animal organ development#GO:0048513;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG191789|UniProtKB=T1FTB8 T1FTB8 20212065 PTHR45080:SF45 CONTACTIN 5 IP11255P transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular component organization or biogenesis#GO:0071840;cell adhesion#GO:0007155;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular process#GO:0009987;homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609 axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;cell body#GO:0044297;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG194060|UniProtKB=T1FVM7 T1FVM7 20212873 PTHR24133:SF60 ANKYRIN DOMAIN-CONTAINING ANKYRIN REPEAT AND SOCS BOX-CONTAINING 3 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160150|UniProtKB=T1EPW1 T1EPW1 20198611 PTHR43250:SF3 EXODEOXYRIBONUCLEASE III CYTOCHROME C OXIDASE SUBUNIT 3 HELRO|EnsemblGenome=HelroG73359|UniProtKB=T1G1D2 T1G1D2 20214880 PTHR12722:SF0 XAP-5 PROTEIN-RELATED PROTEIN FAM50A chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG102759|UniProtKB=T1EDB4 T1EDB4 20194566 PTHR14152:SF5 SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG185980|UniProtKB=T1FNI4 T1FNI4 20210381 PTHR15907:SF223 DUF614 FAMILY PROTEIN-RELATED CELL NUMBER REGULATOR 10 HELRO|EnsemblGenome=HelroG191215|UniProtKB=T1FSR0 T1FSR0 20211857 PTHR10654:SF18 CAS SCAFFOLDING PROTEIN BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell migration#GO:0016477;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG113741|UniProtKB=T1EFV8 T1EFV8 20195460 PTHR10797:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;CCR4-NOT complex#GO:0030014 RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194695|UniProtKB=T1FWB9 T1FWB9 20213115 PTHR21681:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 regulation of translational initiation#GO:0006446;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 eukaryotic translation initiation factor 3 complex#GO:0005852;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG93352|UniProtKB=T1G8V3 T1G8V3 20217500 PTHR45961:SF6 IP21249P IP21249P hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG185612|UniProtKB=T1FN14 T1FN14 20210213 PTHR44040:SF1 RETINOBLASTOMA-BINDING PROTEIN 5 RETINOBLASTOMA-BINDING PROTEIN 5 protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG161862|UniProtKB=T1ERZ1 T1ERZ1 20199341 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78131|UniProtKB=T1G385 T1G385 20215533 PTHR24256:SF519 TRYPTASE-RELATED CHYMOTRYPSINOGEN A-RELATED catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG177760|UniProtKB=T1FC75 T1FC75 20206424 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG85562|UniProtKB=T1G5Z3 T1G5Z3 20216490 PTHR14614:SF167 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN HISTONE-ARGININE METHYLTRANSFERASE METTL23 histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;regulation of biological process#GO:0050789;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164072|UniProtKB=T1EUV7 T1EUV7 20200357 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126929|UniProtKB=T1EHB8 T1EHB8 20195968 PTHR23430:SF50 HISTONE H2A HISTONE H2A structural molecule activity#GO:0005198 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG161680|UniProtKB=T1ERS3 T1ERS3 20199273 PTHR24044:SF448 NOTCH LIGAND FAMILY MEMBER PROTEIN JAGGED-1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Serrate#P01104;Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Next#P01103 HELRO|EnsemblGenome=HelroG94258|UniProtKB=T1G8Z7 T1G8Z7 20217544 PTHR24391:SF27 HISTONE H4 TRANSCRIPTION FACTOR-RELATED ZINC FINGER PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG171242|UniProtKB=T1F3Z6 T1F3Z6 20203545 PTHR46302:SF3 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;regulation of mitotic cytokinesis#GO:1902412;regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;midbody#GO:0030496 HELRO|EnsemblGenome=HelroG181378|UniProtKB=T1FGX8 T1FGX8 20208077 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175205|UniProtKB=T1F902 T1F902 20205301 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG140298|UniProtKB=T1EJ04 T1EJ04 20196554 PTHR24058:SF112 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG121253|UniProtKB=T1EGR1 T1EGR1 20195761 PTHR11309:SF47 FRIZZLED FRIZZLED signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;non-canonical Wnt signaling pathway#GO:0035567 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Angiogenesis#P00005>Fzd#P00189;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG170390|UniProtKB=T1F2Z9 T1F2Z9 20203198 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 protein binding#GO:0005515;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299;SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488 export from cell#GO:0140352;signaling#GO:0023052;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;synaptic signaling#GO:0099536;exocytosis#GO:0006887;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of exocytosis#GO:0017157;localization#GO:0051179;cell communication#GO:0007154;regulation of secretion#GO:0051046;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;axon#GO:0030424;plasma membrane#GO:0005886;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular vesicle#GO:0097708;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG178826|UniProtKB=T1FDS8 T1FDS8 20206977 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED LD39025P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG167455|UniProtKB=T1EZE3 T1EZE3 20201943 PTHR10910:SF62 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN AT07585P-RELATED catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on RNA#GO:0140098;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251;hydrolase activity#GO:0016787;RNA binding#GO:0003723;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101 base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;adenosine to inosine editing#GO:0006382;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77987|UniProtKB=T1G361 T1G361 20215509 PTHR11681:SF5 NEUROPHYSIN ISOTOCIN neuropeptide hormone activity#GO:0005184;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;extracellular region#GO:0005576;intracellular organelle#GO:0043229 peptide hormone#PC00179;neuropeptide#PC00162 Opioid prodynorphin pathway#P05916>prepropressophysin#G06048;Vasopressin synthesis#P04395>Pro-Neurophysin#P04591;Opioid prodynorphin pathway#P05916>provasopressin#P05999;Vasopressin synthesis#P04395>Vasopressin#P04590;Opioid prodynorphin pathway#P05916>vasopressin#P06000;Opioid prodynorphin pathway#P05916>prepropressophysin#G06050;Vasopressin synthesis#P04395>Glycopeptide#P04593;Vasopressin synthesis#P04395>Signal Peptide#P04597;Vasopressin synthesis#P04395>Pro-Vasopressin#P04598;Vasopressin synthesis#P04395>Neurophysin#P04594;Vasopressin synthesis#P04395>Pro2-Vasopressin#P04595 HELRO|EnsemblGenome=HelroG68916|UniProtKB=T1FZL2 T1FZL2 20214260 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170018|UniProtKB=T1F2J4 T1F2J4 20203044 PTHR10177:SF344 CYCLINS G1_S-SPECIFIC CYCLIN-E cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518;cell cycle G1/S phase transition#GO:0044843;positive regulation of cellular process#GO:0048522;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;G1/S transition of mitotic cell cycle#GO:0000082;positive regulation of cell cycle G1/S phase transition#GO:1902808;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;mitotic cell cycle phase transition#GO:0044772;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990 intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 kinase activator#PC00138 p53 pathway feedback loops 2#P04398>cyclin E#P04664;Cell cycle#P00013>Cyclin E#P00483;Cell cycle#P00013>CdkC#P00489;p53 pathway#P00059>Cyclin E#P04610 HELRO|EnsemblGenome=HelroG96656|UniProtKB=T1G9D2 T1G9D2 20217679 PTHR12354:SF1 INTERFERON-RELATED DEVELOPMENTAL REGULATOR INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 HELRO|EnsemblGenome=HelroG153367|UniProtKB=T1EL58 T1EL58 20197302 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG175918|UniProtKB=T1F9W0 T1F9W0 20205609 PTHR31802:SF55 32 KDA HEAT SHOCK PROTEIN-RELATED UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168029|UniProtKB=T1F028 T1F028 20202178 PTHR24023:SF1121 COLLAGEN ALPHA CUTICLE COLLAGEN 99-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922;Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG76235|UniProtKB=T1G2H1 T1G2H1 20215269 PTHR11934:SF0 RIBOSE-5-PHOSPHATE ISOMERASE RIBOSE-5-PHOSPHATE ISOMERASE intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;ribose-5-phosphate isomerase activity#GO:0004751 organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;carbohydrate metabolic process#GO:0005975;pentose-phosphate shunt, non-oxidative branch#GO:0009052;nucleoside phosphate metabolic process#GO:0006753;pentose-phosphate shunt#GO:0006098;pyridine-containing compound metabolic process#GO:0072524;glyceraldehyde-3-phosphate metabolic process#GO:0019682;NADPH regeneration#GO:0006740;nucleotide metabolic process#GO:0009117 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Pentose phosphate pathway#P02762>Ribulose 5-P Isomerase#P03071 HELRO|EnsemblGenome=HelroG63861|UniProtKB=T1FXL2 T1FXL2 20213560 PTHR24112:SF66 LEUCINE-RICH REPEAT, ISOFORM F-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37 HOMOLOG regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell migration#GO:0016477;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007 membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG62632|UniProtKB=T1FX29 T1FX29 20213377 PTHR20921:SF0 TRANSMEMBRANE PROTEIN 222 TRANSMEMBRANE PROTEIN 222 HELRO|EnsemblGenome=HelroG170170|UniProtKB=T1F2Q8 T1F2Q8 20203107 PTHR16038:SF4 NOP SEVEN ASSOCIATED PROTEIN 1 WD REPEAT-CONTAINING PROTEIN 74 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG82003|UniProtKB=T1G4L6 T1G4L6 20216014 PTHR14499:SF148 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING GH08630P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159994|UniProtKB=T1EPM9 T1EPM9 20198529 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89719|UniProtKB=T1G7G4 T1G7G4 20217011 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;cell fate specification#GO:0001708;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG179892|UniProtKB=T1FF83 T1FF83 20207482 PTHR15933:SF20 PROTEIN CBG16327 F-BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177383|UniProtKB=T1FBL4 T1FBL4 20206213 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167450|UniProtKB=T1EZE2 T1EZE2 20201942 PTHR24034:SF111 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE64043P extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG168336|UniProtKB=T1F0F9 T1F0F9 20202309 PTHR11731:SF200 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED VENOM DIPEPTIDYL PEPTIDASE 4 catalytic activity#GO:0003824;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 HELRO|EnsemblGenome=HelroG156513|UniProtKB=T1ELX9 T1ELX9 20197579 PTHR22780:SF4 ADAPTIN, ALPHA/GAMMA/EPSILON AP-2 COMPLEX SUBUNIT ALPHA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583 clathrin vesicle coat#GO:0030125;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated endocytic vesicle#GO:0045334;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;coated membrane#GO:0048475;endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 Huntington disease#P00029>alpha-Adaptin#P00782 HELRO|EnsemblGenome=HelroG166947|UniProtKB=T1EYS8 T1EYS8 20201728 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82341|UniProtKB=T1G4Q8 T1G4Q8 20216056 PTHR11829:SF416 FORKHEAD BOX PROTEIN FORKHEAD DOMAIN 102C sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG189275|UniProtKB=T1FQW7 T1FQW7 20211214 PTHR13817:SF172 TITIN FASCICLIN-2-LIKE PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG176748|UniProtKB=T1FAV4 T1FAV4 20205953 PTHR34098:SF1 F-BOX ONLY PROTEIN 47 F-BOX ONLY PROTEIN 47 HELRO|EnsemblGenome=HelroG67414|UniProtKB=T1FZ04 T1FZ04 20214052 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG184898|UniProtKB=T1FM51 T1FM51 20209900 PTHR11242:SF20 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED AIP_AIPL N-TERMINAL FKBP-TYPE PPIASE DOMAIN-CONTAINING PROTEIN metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein modification process#GO:0036211;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467 membrane#GO:0016020;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG71308|UniProtKB=T1G0J4 T1G0J4 20214592 PTHR10497:SF0 60S RIBOSOMAL PROTEIN L27 LARGE RIBOSOMAL SUBUNIT PROTEIN EL27 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG184998|UniProtKB=T1FM91 T1FM91 20209940 PTHR22912:SF151 DISULFIDE OXIDOREDUCTASE DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;small molecule binding#GO:0036094 pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG104138|UniProtKB=T1EDJ9 T1EDJ9 20194651 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG188024|UniProtKB=T1FPK0 T1FPK0 20210747 PTHR22948:SF84 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED regionalization#GO:0003002;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;cell maturation#GO:0048469;regulatory ncRNA processing#GO:0070918;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;piRNA processing#GO:0034587;pattern specification process#GO:0007389;sexual reproduction#GO:0019953;gene expression#GO:0010467;cellular component assembly#GO:0022607;oogenesis#GO:0048477;embryo development#GO:0009790;RNA processing#GO:0006396;embryonic pattern specification#GO:0009880;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;anterior/posterior axis specification#GO:0009948;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;anterior/posterior pattern specification#GO:0009952;metabolic process#GO:0008152;gamete generation#GO:0007276;cell differentiation#GO:0030154;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163149|UniProtKB=T1ETQ5 T1ETQ5 20199955 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189086|UniProtKB=T1FQM4 T1FQM4 20211121 PTHR19854:SF1 TRANSDUCIN BETA-LIKE 3 GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191861|UniProtKB=T1FTD2 T1FTD2 20212079 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to heat#GO:0009408;response to stress#GO:0006950;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;protein maturation#GO:0051604;gene expression#GO:0010467;protein refolding#GO:0042026;protein metabolic process#GO:0019538;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG67489|UniProtKB=T1FZ16 T1FZ16 20214064 PTHR24329:SF543 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN CEH-17 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;cell development#GO:0048468;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;neuron development#GO:0048666;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron differentiation#GO:0030182;developmental process#GO:0032502 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG102882|UniProtKB=T1EDC7 T1EDC7 20194579 PTHR24095:SF244 ACETYL-COENZYME A SYNTHETASE ACETYL-COENZYME A SYNTHETASE ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;acetyl-CoA metabolic process#GO:0006084;purine-containing compound biosynthetic process#GO:0072522;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637 ligase#PC00142 Acetate utilization#P02722>Acetyl-CoA synthetase#P02803 HELRO|EnsemblGenome=HelroG177242|UniProtKB=T1FBE2 T1FBE2 20206141 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG90848|UniProtKB=T1G7W9 T1G7W9 20217166 PTHR11732:SF506 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE 1B-RELATED catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG110926|UniProtKB=T1EF63 T1EF63 20195215 PTHR12315:SF0 BICOID-INTERACTING PROTEIN RELATED 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME snRNA binding#GO:0017069;RNA binding#GO:0003723;O-methyltransferase activity#GO:0008171;binding#GO:0005488;nucleic acid binding#GO:0003676;methyltransferase activity#GO:0008168;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741 snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG180782|UniProtKB=T1FG99 T1FG99 20207848 PTHR48249:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG161921|UniProtKB=T1ES17 T1ES17 20199367 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG185907|UniProtKB=T1FNF4 T1FNF4 20210351 PTHR19957:SF83 SYNTAXIN SYNTAXIN-16 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031 membrane protein complex#GO:0098796;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG182809|UniProtKB=T1FIS5 T1FIS5 20208724 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67319|UniProtKB=T1FYZ6 T1FYZ6 20214044 PTHR11850:SF59 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN TGIF1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG139475|UniProtKB=T1EIY9 T1EIY9 20196539 PTHR24083:SF4 NUCLEAR HORMONE RECEPTOR PHOTORECEPTOR-SPECIFIC NUCLEAR RECEPTOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG69265|UniProtKB=T1FZS2 T1FZS2 20214320 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;macromolecule localization#GO:0033036;regulation of localization#GO:0032879;regulation of transport#GO:0051049;intracellular protein localization#GO:0008104;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of biological process#GO:0050789;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051 anchoring junction#GO:0070161;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG191127|UniProtKB=T1FSM4 T1FSM4 20211821 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE DNA binding#GO:0003677;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;chromatin DNA binding#GO:0031490;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;binding#GO:0005488;acetyltransferase activity#GO:0016407;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;DPP-SCW signaling pathway#P06212>NEJ#P06260;p53 pathway#P00059>CBP#P04623;Huntington disease#P00029>CBP#P00777;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;DPP signaling pathway#P06213>NEJ#P06284;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295 HELRO|EnsemblGenome=HelroG172670|UniProtKB=T1F5R7 T1F5R7 20204166 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG124255|UniProtKB=T1EH06 T1EH06 20195856 PTHR12151:SF5 ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER AT19154P cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxidase#PC00175 HELRO|EnsemblGenome=HelroG88518|UniProtKB=T1G735 T1G735 20216882 PTHR22950:SF244 AMINO ACID TRANSPORTER NEUTRAL AMINO ACID TRANSPORTER 9 transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HELRO|EnsemblGenome=HelroG172886|UniProtKB=T1F626 T1F626 20204275 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG161089|UniProtKB=T1ER33 T1ER33 20199033 PTHR11902:SF1 ENOLASE ENOLASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;phosphopyruvate hydratase activity#GO:0004634 small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091 catalytic complex#GO:1902494;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 lyase#PC00144;metabolite interconversion enzyme#PC00262 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG63798|UniProtKB=T1FXK4 T1FXK4 20213552 PTHR24193:SF132 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG192938|UniProtKB=T1FUF8 T1FUF8 20212454 PTHR23119:SF44 DISCS LARGE PROTEIN LAP4 kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;protein localization to cell junction#GO:1902414;establishment or maintenance of apical/basal cell polarity#GO:0035088;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;establishment or maintenance of bipolar cell polarity#GO:0061245;protein localization to plasma membrane#GO:0072659;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transport#GO:0006810;biological regulation#GO:0065007;macromolecule localization#GO:0033036;endosome to plasma membrane protein transport#GO:0099638;cellular localization#GO:0051641;protein transport#GO:0015031;regulation of biological quality#GO:0065008;establishment or maintenance of cell polarity#GO:0007163;receptor clustering#GO:0043113;cell adhesion#GO:0007155;endocytic recycling#GO:0032456;protein localization to membrane#GO:0072657;protein localization to synapse#GO:0035418;endosomal transport#GO:0016197;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;protein localization to cell periphery#GO:1990778;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;establishment of protein localization to membrane#GO:0090150;cell-cell adhesion#GO:0098609;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;basal part of cell#GO:0045178;anchoring junction#GO:0070161;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cell junction#GO:0030054;adherens junction#GO:0005912;synaptic membrane#GO:0097060 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189902|UniProtKB=T1FRG7 T1FRG7 20211414 PTHR12873:SF7 T7-LIKE MITOCHONDRIAL DNA HELICASE TWINKLE MTDNA HELICASE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG158868|UniProtKB=T1ENC6 T1ENC6 20198076 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63060|UniProtKB=T1FXA5 T1FXA5 20213453 PTHR43015:SF1 D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 transferase#PC00220 HELRO|EnsemblGenome=HelroG89896|UniProtKB=T1G7I9 T1G7I9 20217036 PTHR20855:SF152 ADIPOR/PROGESTIN RECEPTOR-RELATED ADIPONECTIN RECEPTOR PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG168497|UniProtKB=T1F0N0 T1F0N0 20202380 PTHR46674:SF1 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 binding#GO:0005488;Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072;protein binding#GO:0005515 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;multicellular organismal reproductive process#GO:0048609;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;male gamete generation#GO:0048232;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;spermatogenesis#GO:0007283;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HELRO|EnsemblGenome=HelroG157895|UniProtKB=T1EMH5 T1EMH5 20197775 PTHR21292:SF1 EXOCYST COMPLEX COMPONENT SEC6-RELATED EXOCYST COMPLEX COMPONENT 3 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;exocyst#GO:0000145;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG176353|UniProtKB=T1FAF4 T1FAF4 20205803 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175776|UniProtKB=T1F9N1 T1F9N1 20205530 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521 DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG187947|UniProtKB=T1FPH9 T1FPH9 20210726 PTHR23176:SF133 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN GTPASE-ACTIVATING PROTEIN PAC-1 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG188483|UniProtKB=T1FQ15 T1FQ15 20210912 PTHR45617:SF169 LEUCINE RICH REPEAT FAMILY PROTEIN LP04042P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181941|UniProtKB=T1FHH4 T1FHH4 20208273 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185030|UniProtKB=T1FMB1 T1FMB1 20209960 PTHR45954:SF1 LD33695P LD33695P binding#GO:0005488;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 cell cycle process#GO:0022402;establishment of cell polarity#GO:0030010;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;establishment of organelle localization#GO:0051656;mitotic cell cycle#GO:0000278;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;localization#GO:0051179;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cell periphery#GO:0071944;cell cortex#GO:0005938 HELRO|EnsemblGenome=HelroG164330|UniProtKB=T1EV95 T1EV95 20200495 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG70875|UniProtKB=T1G0D3 T1G0D3 20214531 PTHR10484:SF0 HISTONE H4 HISTONE H4 TYPE VIII structural molecule activity#GO:0005198 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG151217|UniProtKB=T1EKI9 T1EKI9 20197089 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG95902|UniProtKB=T1G987 T1G987 20217634 PTHR43888:SF10 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ-LIKE-2, ISOFORM A molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671 response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;protein folding#GO:0006457;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein refolding#GO:0042026;response to stress#GO:0006950;response to heat#GO:0009408;cellular response to heat#GO:0034605;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 chaperone#PC00072 HELRO|EnsemblGenome=HelroG194288|UniProtKB=T1FVW5 T1FVW5 20212961 PTHR23351:SF24 FOS TRANSCRIPTION FACTOR-RELATED ACTIVATING TRANSCRIPTION FACTOR 3-RELATED basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG170359|UniProtKB=T1F2Y8 T1F2Y8 20203187 PTHR13793:SF164 PHD FINGER PROTEINS ALHAMBRA, ISOFORM P chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185598|UniProtKB=T1FN07 T1FN07 20210206 PTHR21240:SF27 2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 cellular process#GO:0009987;metabolic process#GO:0008152;secondary metabolic process#GO:0019748 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG114306|UniProtKB=T1EG08 T1EG08 20195510 PTHR13183:SF4 AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28 AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1 binding#GO:0005488;protein binding#GO:0005515 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;ciliary base#GO:0097546;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG160117|UniProtKB=T1EPT9 T1EPT9 20198589 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162130|UniProtKB=T1ES96 T1ES96 20199446 PTHR31784:SF3 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;BLOC-1 complex#GO:0031083;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG156985|UniProtKB=T1EM44 T1EM44 20197644 PTHR43389:SF4 V-TYPE PROTON ATPASE SUBUNIT B V-TYPE PROTON ATPASE SUBUNIT B transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;proton transmembrane transport#GO:1902600;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;transporter complex#GO:1990351 ATP synthase#PC00002;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG185904|UniProtKB=T1FNF2 T1FNF2 20210349 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG86450|UniProtKB=T1G6C4 T1G6C4 20216621 PTHR12231:SF274 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE PROTEOGLYCAN-RELATED binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell junction#GO:0030054;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG185832|UniProtKB=T1FNC6 T1FNC6 20210323 PTHR43570:SF16 ALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;metabolic process#GO:0008152 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG180071|UniProtKB=T1FFF9 T1FFF9 20207558 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG126731|UniProtKB=T1EHA8 T1EHA8 20195958 PTHR24248:SF209 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 5A ISOFORM X1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG106916|UniProtKB=T1EE59 T1EE59 20194861 PTHR22572:SF15 SUGAR-1-PHOSPHATE GUANYL TRANSFERASE MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE CATALYTIC SUBUNIT BETA nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 organophosphate metabolic process#GO:0019637;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;macromolecule metabolic process#GO:0043170;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 Mannose metabolism#P02752>Mannose 1-P guanylyl transferase#P03018 HELRO|EnsemblGenome=HelroG183610|UniProtKB=T1FJX5 T1FJX5 20209124 PTHR42757:SF32 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED PROTEIN AMALGAM cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG178784|UniProtKB=T1FDQ6 T1FDQ6 20206955 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190510|UniProtKB=T1FS22 T1FS22 20211619 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN LD44267P cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185726|UniProtKB=T1FN73 T1FN73 20210271 PTHR42808:SF3 HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG162523|UniProtKB=T1ESS7 T1ESS7 20199627 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;U4/U6 x U5 tri-snRNP complex#GO:0046540;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG162425|UniProtKB=T1ESM9 T1ESM9 20199579 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity#GO:0003824 catabolic process#GO:0009056;sulfur compound catabolic process#GO:0044273;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG72093|UniProtKB=T1G0V5 T1G0V5 20214703 PTHR23310:SF51 ACYL-COA-BINDING PROTEIN, ACBP ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 7 lipid binding#GO:0008289;heterocyclic compound binding#GO:1901363;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG193239|UniProtKB=T1FUS2 T1FUS2 20212568 PTHR19932:SF10 WD REPEAT AND HMG-BOX DNA BINDING PROTEIN WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1 binding#GO:0005488;chromatin binding#GO:0003682 macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049 intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG186053|UniProtKB=T1FNL8 T1FNL8 20210415 PTHR48043:SF168 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 HELRO|EnsemblGenome=HelroG82441|UniProtKB=T1G4S2 T1G4S2 20216070 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG78758|UniProtKB=T1G3F3 T1G3F3 20215601 PTHR43382:SF2 PROLYL-TRNA SYNTHETASE BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG191028|UniProtKB=T1FSI6 T1FSI6 20211783 PTHR21669:SF1 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS WASH COMPLEX SUBUNIT 2 lipid binding#GO:0008289;protein-containing complex binding#GO:0044877;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;binding#GO:0005488 intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;protein localization to organelle#GO:0033365;cytosolic transport#GO:0016482 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83294|UniProtKB=T1G536 T1G536 20216184 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165352|UniProtKB=T1EWM4 T1EWM4 20200974 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174990|UniProtKB=T1F8P7 T1F8P7 20205196 PTHR10166:SF37 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED STOLID, ISOFORM H monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891 voltage-gated ion channel#PC00241;transporter#PC00227 HELRO|EnsemblGenome=HelroG174248|UniProtKB=T1F7V7 T1F7V7 20204906 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG150681|UniProtKB=T1EKG8 T1EKG8 20197068 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG159665|UniProtKB=T1EPA5 T1EPA5 20198405 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HELRO|EnsemblGenome=HelroG169864|UniProtKB=T1F2E1 T1F2E1 20202991 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG90150|UniProtKB=T1G7L7 T1G7L7 20217064 PTHR10680:SF39 PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxidoreductase#PC00176;oxygenase#PC00177;metabolite interconversion enzyme#PC00262 Vasopressin synthesis#P04395>Amidating Enzyme#P04599 HELRO|EnsemblGenome=HelroG78253|UniProtKB=T1G398 T1G398 20215546 PTHR10217:SF637 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL EAG-LIKE K[+] CHANNEL, ISOFORM A transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 transport#GO:0006810;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG169784|UniProtKB=T1F2B5 T1F2B5 20202965 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896;protein refolding#GO:0042026;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to heat#GO:0009408;response to stress#GO:0006950;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG190775|UniProtKB=T1FSA3 T1FSA3 20211700 PTHR14352:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;cellular process#GO:0009987;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059 HAUS complex#GO:0070652;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG155980|UniProtKB=T1ELQ3 T1ELQ3 20197503 PTHR46141:SF1 SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN SODIUM LEAK CHANNEL NALCN monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 positive regulation of signaling#GO:0023056;positive regulation of synaptic transmission#GO:0050806;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HELRO|EnsemblGenome=HelroG190297|UniProtKB=T1FRV6 T1FRV6 20211553 PTHR46896:SF3 SENTRIN-SPECIFIC PROTEASE FI06413P-RELATED protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG115877|UniProtKB=T1EGB4 T1EGB4 20195616 PTHR45672:SF2 PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED PROTEIN DISULFIDE-ISOMERASE A5 catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 HELRO|EnsemblGenome=HelroG178284|UniProtKB=T1FD12 T1FD12 20206711 PTHR24173:SF74 ANKYRIN REPEAT CONTAINING ANK_REP_REGION DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG99280|UniProtKB=T1G9R8 T1G9R8 20217814 PTHR44321:SF1 TRANSDUCIN BETA-LIKE PROTEIN 2 TRANSDUCIN BETA-LIKE PROTEIN 2 biological regulation#GO:0065007;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;signal transduction#GO:0007165;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG193600|UniProtKB=T1FV59 T1FV59 20212705 PTHR21077:SF5 EME1 PROTEIN CROSSOVER JUNCTION ENDONUCLEASE MMS4 meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;reciprocal homologous recombination#GO:0140527;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;homologous recombination#GO:0035825;reproductive process#GO:0022414;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;DNA integrity checkpoint signaling#GO:0031570;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;resolution of meiotic recombination intermediates#GO:0000712;DNA damage checkpoint signaling#GO:0000077;replication fork processing#GO:0031297;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle#GO:0045930;cellular component organization#GO:0016043;meiosis I#GO:0007127;negative regulation of cell cycle phase transition#GO:1901988;meiotic cell cycle process#GO:1903046;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564 catalytic complex#GO:1902494;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG155690|UniProtKB=T1ELK5 T1ELK5 20197455 PTHR10840:SF0 PROGRAMMED CELL DEATH PROTEIN 5 PROGRAMMED CELL DEATH PROTEIN 5 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG68359|UniProtKB=T1FZD6 T1FZD6 20214184 PTHR11241:SF0 DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE cation binding#GO:0043169;magnesium ion binding#GO:0000287;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;ion binding#GO:0043167;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside triphosphate diphosphatase activity#GO:0047429;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;nucleoside monophosphate biosynthetic process#GO:0009124;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152 hydrolase#PC00121;phosphatase#PC00181 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUTP pyrophosphatase#P02918 HELRO|EnsemblGenome=HelroG82886|UniProtKB=T1G4X9 T1G4X9 20216127 PTHR13172:SF5 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9 protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 mitochondrial intermembrane space#GO:0005758;mitochondrial envelope#GO:0005740;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG122480|UniProtKB=T1EGU7 T1EGU7 20195797 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG189246|UniProtKB=T1FQV1 T1FQV1 20211198 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;nervous system development#GO:0007399;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;positive regulation of cell population proliferation#GO:0008284;negative regulation of biological process#GO:0048519;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;epidermal growth factor receptor signaling pathway#GO:0007173;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 signaling receptor complex#GO:0043235;membrane#GO:0016020;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HELRO|EnsemblGenome=HelroG190263|UniProtKB=T1FRU1 T1FRU1 20211538 PTHR13832:SF354 PROTEIN PHOSPHATASE 2C GM14138P hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG182979|UniProtKB=T1FJ14 T1FJ14 20208813 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183747|UniProtKB=T1FK48 T1FK48 20209197 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG67821|UniProtKB=T1FZ58 T1FZ58 20214106 PTHR45969:SF69 RING ZINC FINGER PROTEIN-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 HELRO|EnsemblGenome=HelroG188001|UniProtKB=T1FPJ3 T1FPJ3 20210740 PTHR31540:SF1 CENTROSOMAL PROTEIN OF 131 KDA CENTROSOMAL PROTEIN OF 131 KDA cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;gamete generation#GO:0007276;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;microtubule-based transport#GO:0099111;cilium or flagellum-dependent cell motility#GO:0001539;cellular localization#GO:0051641;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cilium movement involved in cell motility#GO:0060294;intraciliary transport involved in cilium assembly#GO:0035735;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;intraciliary transport#GO:0042073;organelle assembly#GO:0070925;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;localization#GO:0051179;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;male gamete generation#GO:0048232;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;intracellular transport#GO:0046907;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;spermatogenesis#GO:0007283;developmental process#GO:0032502;transport along microtubule#GO:0010970;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;sperm axoneme assembly#GO:0007288 HELRO|EnsemblGenome=HelroG98081|UniProtKB=T1G9K4 T1G9K4 20217750 PTHR13832:SF792 PROTEIN PHOSPHATASE 2C GM14286P hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein phosphatase#PC00195 DPP signaling pathway#P06213>PDP#P06280;BMP/activin signaling pathway-drosophila#P06211>PDP#P06248;SCW signaling pathway#P06216>PDP#P06324;GBB signaling pathway#P06214>PDP#P06297;DPP-SCW signaling pathway#P06212>PDP#P06262 HELRO|EnsemblGenome=HelroG194521|UniProtKB=T1FW56 T1FW56 20213052 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212 HELRO|EnsemblGenome=HelroG83053|UniProtKB=T1G4Z6 T1G4Z6 20216144 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG75957|UniProtKB=T1G2D2 T1G2D2 20215230 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG175358|UniProtKB=T1F969 T1F969 20205368 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153971|UniProtKB=T1ELD3 T1ELD3 20197383 PTHR16255:SF1 REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;positive regulation of translation#GO:0045727;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of protein metabolic process#GO:0051247;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 HELRO|EnsemblGenome=HelroG182640|UniProtKB=T1FIJ0 T1FIJ0 20208639 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110736|UniProtKB=T1EF48 T1EF48 20195200 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG157496|UniProtKB=T1EMC4 T1EMC4 20197724 PTHR43607:SF10 V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A H(+)-TRANSPORTING TWO-SECTOR ATPASE monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;cation-transporting ATPase complex#GO:0090533;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;lysosomal membrane#GO:0005765;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG78329|UniProtKB=T1G3A7 T1G3A7 20215555 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;bicarbonate transmembrane transporter activity#GO:0015106;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293 transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG123857|UniProtKB=T1EGZ4 T1EGZ4 20195844 PTHR11741:SF0 ELONGATION FACTOR TS ELONGATION FACTOR TS, MITOCHONDRIAL translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG97629|UniProtKB=T1G9I1 T1G9I1 20217728 PTHR11662:SF40 SOLUTE CARRIER FAMILY 17 INORGANIC PHOSPHATE COTRANSPORTER-LIKE PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG67796|UniProtKB=T1FZ54 T1FZ54 20214102 PTHR13844:SF95 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D BRAHMA-ASSOCIATED PROTEIN OF 60 KDA transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG188513|UniProtKB=T1FQ29 T1FQ29 20210926 PTHR12555:SF13 UBIQUITIN FUSION DEGRADATON PROTEIN 1 UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1 protein binding#GO:0005515;modification-dependent protein binding#GO:0140030;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG81400|UniProtKB=T1G4E0 T1G4E0 20215938 PTHR42780:SF1 SOLEUCYL-TRNA SYNTHETASE ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;cytosol#GO:0005829;catalytic complex#GO:1902494 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG177165|UniProtKB=T1FBA9 T1FBA9 20206108 PTHR48233:SF4 MUCIN 4B, ISOFORM B-RELATED MUCIN 4B, ISOFORM B-RELATED HELRO|EnsemblGenome=HelroG170911|UniProtKB=T1F3L2 T1F3L2 20203411 PTHR45632:SF40 LD33804P KELCH-LIKE PROTEIN 12 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165753|UniProtKB=T1EX91 T1EX91 20201191 PTHR47027:SF25 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161485|UniProtKB=T1ERJ1 T1ERJ1 20199191 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG82517|UniProtKB=T1G4T1 T1G4T1 20216079 PTHR12560:SF0 LONGEVITY ASSURANCE FACTOR 1 LAG1 LD18904P acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;ceramide metabolic process#GO:0006672 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG71437|UniProtKB=T1G0L7 T1G0L7 20214615 PTHR10885:SF24 ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity#GO:0003824 organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;organophosphate biosynthetic process#GO:0090407;isoprenoid metabolic process#GO:0006720 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 isomerase#PC00135 HELRO|EnsemblGenome=HelroG171808|UniProtKB=T1F4P9 T1F4P9 20203798 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG167609|UniProtKB=T1EZJ8 T1EZJ8 20201998 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG81961|UniProtKB=T1G4L0 T1G4L0 20216008 PTHR13276:SF0 GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4 GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 post-Golgi vesicle-mediated transport#GO:0006892;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193 cytosol#GO:0005829;membrane#GO:0016020;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG184695|UniProtKB=T1FLS5 T1FLS5 20209774 PTHR46579:SF5 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168268|UniProtKB=T1F0D5 T1F0D5 20202285 PTHR22802:SF396 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG62198|UniProtKB=T1FWW9 T1FWW9 20213317 PTHR20967:SF0 PROHORMONE-4 PROHORMONE-4 HELRO|EnsemblGenome=HelroG159295|UniProtKB=T1ENU7 T1ENU7 20198247 PTHR12713:SF39 VACUOLAR ATP SYNTHASE SUBUNIT G V-TYPE PROTON ATPASE SUBUNIT G monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;vesicle-mediated transport#GO:0016192;developmental maturation#GO:0021700;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle organization#GO:0016050;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;proton transmembrane transport#GO:1902600;cellular component organization or biogenesis#GO:0071840;synaptic vesicle maturation#GO:0016188;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;developmental process#GO:0032502;homeostatic process#GO:0042592;cellular component organization#GO:0016043;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cellular localization#GO:0051641;monoatomic cation transport#GO:0006812;localization#GO:0051179 intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cellular anatomical structure#GO:0110165;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG191722|UniProtKB=T1FT83 T1FT83 20212030 PTHR22883:SF23 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC6 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;protein targeting#GO:0006605;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172853|UniProtKB=T1F605 T1F605 20204254 PTHR20956:SF13 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180536|UniProtKB=T1FG13 T1FG13 20207762 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG160102|UniProtKB=T1EPS6 T1EPS6 20198576 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67097|UniProtKB=T1FYW3 T1FYW3 20214011 PTHR22878:SF74 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED STERILE AFFECTING CILIOGENESIS HELRO|EnsemblGenome=HelroG168178|UniProtKB=T1F096 T1F096 20202246 PTHR47174:SF3 BRIDGING INTEGRATOR 3 BRIDGING INTEGRATOR 3 binding#GO:0005488;lipid binding#GO:0008289 establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;localization#GO:0051179;transport#GO:0006810;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endocytosis#GO:0006897;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629 HELRO|EnsemblGenome=HelroG85456|UniProtKB=T1G5X3 T1G5X3 20216470 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE LUCIFERIN 4-MONOOXYGENASE ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 ligase#PC00142 HELRO|EnsemblGenome=HelroG193353|UniProtKB=T1FUW6 T1FUW6 20212612 PTHR10165:SF174 LIPID PHOSPHATE PHOSPHATASE PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cell communication#GO:0007154;dephosphorylation#GO:0016311;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phospholipid dephosphorylation#GO:0046839;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;phospholipid metabolic process#GO:0006644;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG178236|UniProtKB=T1FCZ4 T1FCZ4 20206693 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91254|UniProtKB=T1G820 T1G820 20217217 PTHR21284:SF12 EG:80H7.2 PROTEIN CLAUDIN HELRO|EnsemblGenome=HelroG161993|UniProtKB=T1ES47 T1ES47 20199397 PTHR34090:SF1 39S RIBOSOMAL PROTEIN L52, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML52 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG169436|UniProtKB=T1F1X7 T1F1X7 20202827 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188155|UniProtKB=T1FPP9 T1FPP9 20210796 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE ABNORMAL CELL MIGRATION PROTEIN 18-LIKE FIBRONECTIN TYPE I DOMAIN-CONTAINING PROTEIN-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192841|UniProtKB=T1FUC7 T1FUC7 20212423 PTHR24403:SF67 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG170520|UniProtKB=T1F357 T1F357 20203256 PTHR21622:SF0 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4 protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 localization#GO:0051179;cellular localization#GO:0051641;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;mitochondrial transport#GO:0006839;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;mitochondrial protein import pathway#GO:7770058;protein maturation#GO:0051604;gene expression#GO:0010467 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758 HELRO|EnsemblGenome=HelroG105042|UniProtKB=T1EDP9 T1EDP9 20194701 PTHR11722:SF0 60S RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN EL13 RNA binding#GO:0003723;structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG187914|UniProtKB=T1FPG9 T1FPG9 20210716 PTHR42850:SF4 METALLOPHOSPHOESTERASE ZINC-DEPENDENT ENDOPOLYPHOSPHATASE hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG180276|UniProtKB=T1FFN8 T1FFN8 20207637 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED FI18012P1 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG184020|UniProtKB=T1FKF8 T1FKF8 20209307 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG188055|UniProtKB=T1FPL0 T1FPL0 20210757 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;tissue development#GO:0009888;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812 basement membrane#GO:0005604;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG83631|UniProtKB=T1G584 T1G584 20216231 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267 monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;chloride transmembrane transport#GO:1902476;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG129847|UniProtKB=T1EHS6 T1EHS6 20196126 PTHR13140:SF781 MYOSIN MYOSIN-11 microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG163469|UniProtKB=T1EU36 T1EU36 20200086 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180112|UniProtKB=T1FFH4 T1FFH4 20207573 PTHR10782:SF94 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I ubiquitin-like protein ligase activity#GO:0061659;SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;protein modification by small protein conjugation or removal#GO:0070647;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;protein sumoylation#GO:0016925;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;post-translational protein modification#GO:0043687;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987 membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 ubiquitin-protein ligase#PC00234 Interferon-gamma signaling pathway#P00035>PIAS#P00958 HELRO|EnsemblGenome=HelroG191434|UniProtKB=T1FSZ3 T1FSZ3 20211940 PTHR47238:SF2 MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS non-receptor serine/threonine protein kinase#PC00167 FGF signaling pathway#P00021>MKK4,7#P00637;EGF receptor signaling pathway#P00018>MKK4,7#P00555 HELRO|EnsemblGenome=HelroG179196|UniProtKB=T1FEC3 T1FEC3 20207172 PTHR24339:SF67 HOMEOBOX PROTEIN EMX-RELATED GNOT2 HOMEODOMAIN PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG71212|UniProtKB=T1G0H9 T1G0H9 20214577 PTHR11034:SF40 N-MYC DOWNSTREAM REGULATED BCDNA.GH02439 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG179276|UniProtKB=T1FEG9 T1FEG9 20207218 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG186032|UniProtKB=T1FNK4 T1FNK4 20210401 PTHR11353:SF19 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT THETA ISOFORM X1 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG189271|UniProtKB=T1FQW5 T1FQW5 20211212 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165075|UniProtKB=T1EW94 T1EW94 20200844 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG103807|UniProtKB=T1EDH6 T1EDH6 20194628 PTHR10137:SF0 V-TYPE PROTON ATPASE SUBUNIT C V-TYPE PROTON ATPASE SUBUNIT C ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular membrane-bounded organelle#GO:0043231;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane#GO:0016020 ATP synthase#PC00002 HELRO|EnsemblGenome=HelroG182739|UniProtKB=T1FIN7 T1FIN7 20208686 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG165017|UniProtKB=T1EW51 T1EW51 20200801 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177886|UniProtKB=T1FCF2 T1FCF2 20206501 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184082|UniProtKB=T1FKJ6 T1FKJ6 20209345 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76754|UniProtKB=T1G2P0 T1G2P0 20215338 PTHR21245:SF15 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING PROTEIN 46-LIKE PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG88643|UniProtKB=T1G748 T1G748 20216895 PTHR43330:SF28 METHIONINE AMINOPEPTIDASE METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;metallopeptidase activity#GO:0008237;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG178620|UniProtKB=T1FDG8 T1FDG8 20206867 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG131399|UniProtKB=T1EHV8 T1EHV8 20196158 PTHR10782:SF94 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of nucleobase-containing compound metabolic process#GO:0019219;post-translational protein modification#GO:0043687;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;protein sumoylation#GO:0016925;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of RNA metabolic process#GO:0051252;protein modification by small protein conjugation or removal#GO:0070647 intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 Interferon-gamma signaling pathway#P00035>PIAS#P00958 HELRO|EnsemblGenome=HelroG156856|UniProtKB=T1EM19 T1EM19 20197619 PTHR23065:SF11 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 SYNDAPIN, ISOFORM C phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of endocytosis#GO:0030100;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of localization#GO:0032879 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG167439|UniProtKB=T1EZD7 T1EZD7 20201937 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515 biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular process#GO:0009987;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;localization#GO:0051179;regulation of secretion#GO:0051046;establishment of localization#GO:0051234;transport#GO:0006810 secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG170458|UniProtKB=T1F332 T1F332 20203231 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177668|UniProtKB=T1FC15 T1FC15 20206364 PTHR14155:SF263 RING FINGER DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ATL6 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG193817|UniProtKB=T1FVE1 T1FVE1 20212787 PTHR45761:SF1 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;lipid binding#GO:0008289;cation binding#GO:0043169;phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091;phosphatidylcholine binding#GO:0031210 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192952|UniProtKB=T1FUG4 T1FUG4 20212460 PTHR12480:SF32 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 import into cell#GO:0098657;endocytosis#GO:0006897;establishment of localization#GO:0051234;localization#GO:0051179;phagocytosis#GO:0006909;transport#GO:0006810 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175167|UniProtKB=T1F8Y3 T1F8Y3 20205282 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 HELRO|EnsemblGenome=HelroG184819|UniProtKB=T1FM17 T1FM17 20209866 PTHR19315:SF9 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;protein localization to organelle#GO:0033365;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;cellular process#GO:0009987;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HELRO|EnsemblGenome=HelroG91230|UniProtKB=T1G813 T1G813 20217210 PTHR13832:SF803 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE CG10417-RELATED protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG181141|UniProtKB=T1FGN5 T1FGN5 20207984 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188188|UniProtKB=T1FPR4 T1FPR4 20210811 PTHR18866:SF130 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;ligase#PC00142 Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033 HELRO|EnsemblGenome=HelroG194645|UniProtKB=T1FW99 T1FW99 20213095 PTHR22922:SF20 GPI-ANCHORED PROTEIN P137 CAPRIN HOMOLOG RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184114|UniProtKB=T1FKL7 T1FKL7 20209366 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159004|UniProtKB=T1ENH2 T1ENH2 20198122 PTHR15021:SF0 DISCONNECTED-RELATED DISCO-RELATED, ISOFORM A-RELATED regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG163137|UniProtKB=T1ETP8 T1ETP8 20199948 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114851|UniProtKB=T1EG49 T1EG49 20195551 PTHR21432:SF21 ACETYL-COA HYDROLASE-RELATED GM14349P intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 hydrolase#PC00121 Adenine and hypoxanthine salvage pathway#P02723>Adenosine deaminase#P02811;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine deaminase#P02807 HELRO|EnsemblGenome=HelroG191091|UniProtKB=T1FSL0 T1FSL0 20211807 PTHR45960:SF2 GRB2-ASSOCIATED-BINDING PROTEIN PROTEIN DAUGHTER OF SEVENLESS scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HELRO|EnsemblGenome=HelroG114723|UniProtKB=T1EG43 T1EG43 20195545 PTHR11556:SF1 FRUCTOSE-1,6-BISPHOSPHATASE-RELATED FRUCTOSE-1,6-BISPHOSPHATASE ISOZYME 2 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;sugar-phosphatase activity#GO:0050308;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;glucose metabolic process#GO:0006006;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;cellular process#GO:0009987;gluconeogenesis#GO:0006094;hexose biosynthetic process#GO:0019319;small molecule metabolic process#GO:0044281;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;carbohydrate metabolic process#GO:0005975 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase#PC00181;carbohydrate phosphatase#PC00066;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185674|UniProtKB=T1FN47 T1FN47 20210245 PTHR18884:SF136 SEPTIN SEPTIN-1 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cell cycle process#GO:0022402;cell division#GO:0051301;cellular process#GO:0009987;cell cycle#GO:0007049;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910 microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HELRO|EnsemblGenome=HelroG193553|UniProtKB=T1FV45 T1FV45 20212691 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG181747|UniProtKB=T1FHA0 T1FHA0 20208199 PTHR10513:SF15 DEOXYNUCLEOSIDE KINASE NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;deoxynucleoside kinase activity#GO:0019136 electron transport chain#GO:0022900;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190932|UniProtKB=T1FSF7 T1FSF7 20211754 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG63767|UniProtKB=T1FXK2 T1FXK2 20213550 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174933|UniProtKB=T1F8M6 T1F8M6 20205175 PTHR24338:SF0 HOMEOBOX PROTEIN MSX MUSCLE SEGMENTATION HOMEOBOX transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG107851|UniProtKB=T1EED3 T1EED3 20194935 PTHR13182:SF8 ZINC FINGER PROTEIN 622 CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622 binding#GO:0005488;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021 ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254 preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG180684|UniProtKB=T1FG60 T1FG60 20207809 PTHR11243:SF39 GROWTH FACTOR RECEPTOR-BOUND PROTEIN LD06925P protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular response to stimulus#GO:0051716;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG106711|UniProtKB=T1EE40 T1EE40 20194842 PTHR12358:SF112 SPHINGOSINE KINASE SPHINGOSINE KINASE lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingoid biosynthetic process#GO:0046520;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG153737|UniProtKB=T1ELB3 T1ELB3 20197363 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG190667|UniProtKB=T1FS70 T1FS70 20211667 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR TITIN transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG184309|UniProtKB=T1FKY6 T1FKY6 20209485 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80768|UniProtKB=T1G451 T1G451 20215849 PTHR46532:SF4 MALE FERTILITY FACTOR KL5 DYNEIN HEAVY CHAIN, CYTOPLASMIC Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG130073|UniProtKB=T1EHT0 T1EHT0 20196130 PTHR24229:SF114 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED transmembrane signaling receptor activity#GO:0004888;peptide binding#GO:0042277;neuropeptide binding#GO:0042923;binding#GO:0005488;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG178469|UniProtKB=T1FD77 T1FD77 20206776 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG168124|UniProtKB=T1F071 T1F071 20202221 PTHR13098:SF3 WOLFRAMIN WOLFRAMIN cellular response to unfolded protein#GO:0034620;calcium ion homeostasis#GO:0055074;response to endoplasmic reticulum stress#GO:0034976;inorganic ion homeostasis#GO:0098771;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;endoplasmic reticulum unfolded protein response#GO:0030968;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG154240|UniProtKB=T1ELE2 T1ELE2 20197392 PTHR23137:SF6 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN HELRO|EnsemblGenome=HelroG185057|UniProtKB=T1FMC1 T1FMC1 20209970 PTHR11353:SF24 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT GAMMA macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG63151|UniProtKB=T1FXB6 T1FXB6 20213464 PTHR24034:SF204 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG163581|UniProtKB=T1EU89 T1EU89 20200139 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG181251|UniProtKB=T1FGS8 T1FGS8 20208027 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98481|UniProtKB=T1G9N1 T1G9N1 20217777 PTHR23194:SF16 PYGOPUS PROTEIN PYGOPUS transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;Wnt signaling pathway#GO:0016055;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 Wnt signaling pathway#P00057>Pygo#P01464 HELRO|EnsemblGenome=HelroG119050|UniProtKB=T1EGM4 T1EGM4 20195724 PTHR45628:SF40 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 import across plasma membrane#GO:0098739;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;calcium ion transmembrane transport#GO:0070588;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;calcium ion import#GO:0070509;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;cell-cell signaling#GO:0007267;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022 HELRO|EnsemblGenome=HelroG186734|UniProtKB=T1FP27 T1FP27 20210574 PTHR12176:SF78 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170 metabolite interconversion enzyme#PC00262;transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG91510|UniProtKB=T1G846 T1G846 20217243 PTHR24060:SF171 METABOTROPIC GLUTAMATE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;glutamate receptor activity#GO:0008066;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640 biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;glutamate receptor signaling pathway#GO:0007215;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG74790|UniProtKB=T1G1V7 T1G1V7 20215055 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG73137|UniProtKB=T1G1A7 T1G1A7 20214855 PTHR47992:SF274 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE MN(2+)-DEPENDENT 1K catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG159904|UniProtKB=T1EPJ2 T1EPJ2 20198492 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG94059|UniProtKB=T1G8Y7 T1G8Y7 20217534 PTHR32546:SF26 G-PROTEIN COUPLED RECEPTOR 158-RELATED SMOG, ISOFORM D G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184381|UniProtKB=T1FL34 T1FL34 20209533 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190075|UniProtKB=T1FRN6 T1FRN6 20211483 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG175162|UniProtKB=T1F8X9 T1F8X9 20205278 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG175909|UniProtKB=T1F9V3 T1F9V3 20205602 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182434|UniProtKB=T1FI69 T1FI69 20208518 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG103921|UniProtKB=T1EDI5 T1EDI5 20194637 PTHR28599:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 12 SMALL INTEGRAL MEMBRANE PROTEIN 12 HELRO|EnsemblGenome=HelroG73251|UniProtKB=T1G1C1 T1G1C1 20214869 PTHR14463:SF10 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 1 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG73015|UniProtKB=T1G186 T1G186 20214834 PTHR23280:SF25 4.1 G PROTEIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG114448|UniProtKB=T1EG18 T1EG18 20195520 PTHR14557:SF5 PROTEIN C7ORF21 UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 HELRO|EnsemblGenome=HelroG194636|UniProtKB=T1FW94 T1FW94 20213090 PTHR10762:SF2 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG188313|UniProtKB=T1FPV2 T1FPV2 20210849 PTHR10574:SF444 NETRIN/LAMININ-RELATED BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN anatomical structure development#GO:0048856;tissue development#GO:0009888;developmental process#GO:0032502 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG157983|UniProtKB=T1EMI5 T1EMI5 20197785 PTHR10663:SF415 GUANYL-NUCLEOTIDE EXCHANGE FACTOR LD29171P organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG89387|UniProtKB=T1G7C6 T1G7C6 20216973 PTHR48021:SF1 FAMILY NOT NAMED MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG162271|UniProtKB=T1ESF8 T1ESF8 20199508 PTHR34343:SF1 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 cell differentiation#GO:0030154;cell motility#GO:0048870;cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;anatomical structure morphogenesis#GO:0009653;tube morphogenesis#GO:0035239;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell migration#GO:0016477;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;tube development#GO:0035295;nervous system development#GO:0007399;organelle organization#GO:0006996;cellular process#GO:0009987;multicellular organism development#GO:0007275;neuron migration#GO:0001764;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;microtubule organizing center organization#GO:0031023;neurogenesis#GO:0022008;microtubule-based process#GO:0007017;anatomical structure formation involved in morphogenesis#GO:0048646;developmental process#GO:0032502 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HELRO|EnsemblGenome=HelroG184815|UniProtKB=T1FM16 T1FM16 20209865 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG99321|UniProtKB=T1G9S2 T1G9S2 20217818 PTHR11373:SF4 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE FALTEN, ISOFORM B hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;purine nucleotide catabolic process#GO:0006195;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleotide metabolic process#GO:0006163;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG159632|UniProtKB=T1EP97 T1EP97 20198397 PTHR11176:SF62 BOULE-RELATED PROTEIN BOULE translation regulator activity#GO:0045182 regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;regulation of translational initiation#GO:0006446;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of RNA metabolic process#GO:0051252;positive regulation of translation#GO:0045727;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG163187|UniProtKB=T1ETS2 T1ETS2 20199972 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG SPT20 HOMOLOG, SAGA COMPLEX COMPONENT-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;SAGA complex#GO:0000124;chromatin#GO:0000785;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG194818|UniProtKB=T1FWG3 T1FWG3 20213158 PTHR33447:SF2 GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 cellular detoxification#GO:1990748;cellular response to chemical stimulus#GO:0070887;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;response to metal ion#GO:0010038;metabolic process#GO:0008152;response to cadmium ion#GO:0046686;cellular process#GO:0009987;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;detoxification#GO:0098754;biosynthetic process#GO:0009058;cellular response to toxic substance#GO:0097237;response to chemical#GO:0042221 HELRO|EnsemblGenome=HelroG175810|UniProtKB=T1F9P6 T1F9P6 20205545 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG114837|UniProtKB=T1EG48 T1EG48 20195550 PTHR11360:SF286 MONOCARBOXYLATE TRANSPORTER GH22266P-RELATED carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monocarboxylic acid transmembrane transporter activity#GO:0008028 monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG167712|UniProtKB=T1EZP9 T1EZP9 20202049 PTHR31598:SF1 IQ DOMAIN-CONTAINING PROTEIN D DYNEIN REGULATORY COMPLEX SUBUNIT 10 HELRO|EnsemblGenome=HelroG167974|UniProtKB=T1F009 T1F009 20202159 PTHR46908:SF8 CUBILIN-LIKE PROTEIN CUBILIN 2 HELRO|EnsemblGenome=HelroG181421|UniProtKB=T1FGZ8 T1FGZ8 20208097 PTHR15696:SF0 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 TELOMERASE-BINDING PROTEIN EST1A sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;RNA binding#GO:0003723;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG105284|UniProtKB=T1EDT0 T1EDT0 20194732 PTHR42884:SF38 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 proteolysis#GO:0006508;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;DPP signaling pathway#P06213>FUR1#P06290;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Activin beta signaling pathway#P06210>FUR1#P06238;DPP-SCW signaling pathway#P06212>FUR1#P06263;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;Endothelin signaling pathway#P00019>furin#P00575;MYO signaling pathway#P06215>FUR1#P06318;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG176722|UniProtKB=T1FAU0 T1FAU0 20205939 PTHR24406:SF42 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG108698|UniProtKB=T1EEL6 T1EEL6 20195018 PTHR45903:SF1 GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1 GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HELRO|EnsemblGenome=HelroG175217|UniProtKB=T1F911 T1F911 20205310 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED FI18012P1 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG161777|UniProtKB=T1ERW6 T1ERW6 20199316 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184934|UniProtKB=T1FM66 T1FM66 20209915 PTHR24073:SF185 DRAB5-RELATED RAS-RELATED PROTEIN RAB-14 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;phagocytosis#GO:0006909;intracellular transport#GO:0046907;phagolysosome assembly#GO:0001845;lytic vacuole organization#GO:0080171;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;cellular process#GO:0009987;lysosome organization#GO:0007040;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;vacuole organization#GO:0007033;post-Golgi vesicle-mediated transport#GO:0006892;organelle assembly#GO:0070925;endocytosis#GO:0006897;cytosolic transport#GO:0016482;cellular component organization#GO:0016043;Golgi to endosome transport#GO:0006895 intracellular vesicle#GO:0097708;vesicle#GO:0031982;phagocytic vesicle#GO:0045335;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG186943|UniProtKB=T1FP46 T1FP46 20210593 PTHR14248:SF40 CYCLIN Y, ISOFORM A CYCLIN Y, ISOFORM A cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG192409|UniProtKB=T1FTX4 T1FTX4 20212271 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG188911|UniProtKB=T1FQH0 T1FQH0 20211067 PTHR46227:SF2 GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP FI03335P transport#GO:0006810;intracellular protein transport#GO:0006886;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;protein localization to synapse#GO:0035418;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endosome to plasma membrane protein transport#GO:0099638;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;protein localization to cell junction#GO:1902414;regulation of biological quality#GO:0065008;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;endocytic recycling#GO:0032456 HELRO|EnsemblGenome=HelroG170428|UniProtKB=T1F317 T1F317 20203216 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE MGP4 catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186439|UniProtKB=T1FNZ6 T1FNZ6 20210543 PTHR10857:SF102 COPINE COPINE-3 lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 response to stimulus#GO:0050896;response to calcium ion#GO:0051592;response to chemical#GO:0042221;response to metal ion#GO:0010038;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG79043|UniProtKB=T1G3J1 T1G3J1 20215639 PTHR19229:SF275 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2 lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid transport#GO:0006869;localization#GO:0051179;establishment of localization#GO:0051234;lipid localization#GO:0010876;macromolecule localization#GO:0033036;transport#GO:0006810 intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG169153|UniProtKB=T1F1H5 T1F1H5 20202675 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG66532|UniProtKB=T1FYM5 T1FYM5 20213923 PTHR46367:SF1 ATAXIN-7-LIKE PROTEIN 3 ATAXIN-7-LIKE PROTEIN 3 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355 chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461;nucleus#GO:0005634;chromatin#GO:0000785;SAGA complex#GO:0000124;DUBm complex#GO:0071819;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG165178|UniProtKB=T1EWE0 T1EWE0 20200890 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG SPT20 HOMOLOG, SAGA COMPLEX COMPONENT-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;SAGA complex#GO:0000124;chromatin#GO:0000785;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG177759|UniProtKB=T1FC74 T1FC74 20206423 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181719|UniProtKB=T1FH92 T1FH92 20208191 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN binding#GO:0005488;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG94350|UniProtKB=T1G904 T1G904 20217551 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG153356|UniProtKB=T1EL49 T1EL49 20197299 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG175544|UniProtKB=T1F9D3 T1F9D3 20205432 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG164315|UniProtKB=T1EV92 T1EV92 20200492 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 transferase#PC00220 HELRO|EnsemblGenome=HelroG194466|UniProtKB=T1FW30 T1FW30 20213026 PTHR10694:SF148 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG155914|UniProtKB=T1ELP2 T1ELP2 20197492 PTHR12817:SF0 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;TRAPP complex#GO:0030008;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;Golgi apparatus subcompartment#GO:0098791 HELRO|EnsemblGenome=HelroG82139|UniProtKB=T1G4N5 T1G4N5 20216033 PTHR22939:SF132 SERINE PROTEASE FAMILY S1C HTRA-RELATED SERINE PROTEASE HTRA2, MITOCHONDRIAL serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;proteolysis#GO:0006508;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG84564|UniProtKB=T1G5K4 T1G5K4 20216351 PTHR20934:SF0 TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;binding#GO:0005488 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleoplasm#GO:0005654 HELRO|EnsemblGenome=HelroG101296|UniProtKB=T1ED37 T1ED37 20194490 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 mitotic cell cycle phase transition#GO:0044772;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cell cycle process#GO:0022402;regulation of meiotic cell cycle#GO:0051445;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;regulation of cell cycle#GO:0051726;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G2/M phase transition#GO:0044839;regulation of reproductive process#GO:2000241;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187050|UniProtKB=T1FP63 T1FP63 20210610 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MULTIDRUG RESISTANCE PROTEIN HOMOLOG 49-RELATED transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG189284|UniProtKB=T1FQX1 T1FQX1 20211218 PTHR10909:SF250 ELECTRON TRANSPORT OXIDOREDUCTASE ACYL-COENZYME A OXIDASE-RELATED oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;fatty acid binding#GO:0005504;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;lipid binding#GO:0008289;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;organic acid binding#GO:0043177 lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG187088|UniProtKB=T1FP68 T1FP68 20210615 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG158127|UniProtKB=T1EMJ6 T1EMJ6 20197796 PTHR46246:SF1 GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1 GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG63446|UniProtKB=T1FXF9 T1FXF9 20213507 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;system process#GO:0003008;actin filament organization#GO:0007015;muscle contraction#GO:0006936;actin filament-based process#GO:0030029;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;muscle system process#GO:0003012;cellular process#GO:0009987 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG191443|UniProtKB=T1FSZ8 T1FSZ8 20211945 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN channel activity#GO:0015267;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;binding#GO:0005488;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;transporter activity#GO:0005215 intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;metal ion transport#GO:0030001;regulation of cytosolic calcium ion concentration#GO:0051480;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG177051|UniProtKB=T1FB65 T1FB65 20206064 PTHR12654:SF0 BILE ACID BETA-GLUCOSIDASE-RELATED NON-LYSOSOMAL GLUCOSYLCERAMIDASE glucosidase#PC00108;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161348|UniProtKB=T1ERD4 T1ERD4 20199134 PTHR21096:SF0 PROTEIN FAM136A TIM DOUBLE TWIN CX3C MOTIF PROTEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177880|UniProtKB=T1FCE9 T1FCE9 20206498 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175277|UniProtKB=T1F934 T1F934 20205333 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN-RELATED HELRO|EnsemblGenome=HelroG91367|UniProtKB=T1G830 T1G830 20217227 PTHR11216:SF178 EH DOMAIN AT21416P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;organelle assembly#GO:0070925;endocytic recycling#GO:0032456;cell projection organization#GO:0030030;endocytosis#GO:0006897;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to plasma membrane#GO:0072659 cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;recycling endosome#GO:0055037;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG159699|UniProtKB=T1EPB8 T1EPB8 20198418 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG71408|UniProtKB=T1G0L0 T1G0L0 20214608 PTHR11208:SF45 RNA-BINDING PROTEIN RELATED SPLICING FACTOR 1 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG190316|UniProtKB=T1FRW4 T1FRW4 20211561 PTHR13663:SF2 SIMILAR TO RIKEN CDNA 6430548M08 RIKEN CDNA 6430548M08 GENE LIKE HELRO|EnsemblGenome=HelroG151325|UniProtKB=T1EKJ6 T1EKJ6 20197096 PTHR21404:SF3 HEN1 SMALL RNA 2'-O-METHYLTRANSFERASE HELRO|EnsemblGenome=HelroG142669|UniProtKB=T1EJ68 T1EJ68 20196618 PTHR24343:SF348 SERINE/THREONINE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;cellular process#GO:0009987;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76471|UniProtKB=T1G2K3 T1G2K3 20215301 PTHR24291:SF216 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7 metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185265|UniProtKB=T1FML0 T1FML0 20210059 PTHR16505:SF8 PROTEIN LZIC PROTEIN LZIC HELRO|EnsemblGenome=HelroG115475|UniProtKB=T1EG85 T1EG85 20195587 PTHR21569:SF16 RIBOSOMAL PROTEIN S9 SMALL RIBOSOMAL SUBUNIT PROTEIN US9 structural molecule activity#GO:0005198;RNA binding#GO:0003723;binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG167096|UniProtKB=T1EZ08 T1EZ08 20201808 PTHR22426:SF2 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 HELRO|EnsemblGenome=HelroG180050|UniProtKB=T1FFE4 T1FFE4 20207543 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG193840|UniProtKB=T1FVE8 T1FVE8 20212794 PTHR24201:SF20 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42-LIKE protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG111094|UniProtKB=T1EF80 T1EF80 20195232 PTHR43856:SF3 CARDIOLIPIN HYDROLASE MITOCHONDRIAL CARDIOLIPIN HYDROLASE catalytic activity, acting on a nucleic acid#GO:0140640;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;lipase activity#GO:0016298;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;cell differentiation#GO:0030154;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;oogenesis#GO:0048477;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321 mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG186178|UniProtKB=T1FNS0 T1FNS0 20210467 PTHR22839:SF0 THO COMPLEX SUBUNIT 3 THO3 THO COMPLEX SUBUNIT 3 nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription export complex#GO:0000346;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194606|UniProtKB=T1FW86 T1FW86 20213082 PTHR24408:SF58 ZINC FINGER PROTEIN LINKING IMMUNITY AND METABOLISM-RELATED DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG170243|UniProtKB=T1F2T7 T1F2T7 20203136 PTHR11462:SF60 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;response to steroid hormone#GO:0048545;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;response to lipid#GO:0033993;positive regulation of transcription by RNA polymerase II#GO:0045944;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG193055|UniProtKB=T1FUK8 T1FUK8 20212504 PTHR45662:SF8 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 PHOSPHATIDYLINOSITIDE 4-PHOSPHATASE SAC2 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;biological regulation#GO:0065007;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;lipid modification#GO:0030258;regulation of localization#GO:0032879;regulation of transport#GO:0051049 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endocytic vesicle#GO:0030139;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;cytoplasm#GO:0005737;endomembrane system#GO:0012505;clathrin-coated endocytic vesicle#GO:0045334;endoplasmic reticulum#GO:0005783;clathrin-coated vesicle#GO:0030136 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG91150|UniProtKB=T1G803 T1G803 20217200 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG63009|UniProtKB=T1FX96 T1FX96 20213444 PTHR11850:SF419 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN PKNOX2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG75879|UniProtKB=T1G2C1 T1G2C1 20215219 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG105902|UniProtKB=T1EDY4 T1EDY4 20194786 PTHR13087:SF0 NF-KAPPA B ACTIVATING PROTEIN NFKB ACTIVATING PROTEIN LIKE biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG191122|UniProtKB=T1FSM2 T1FSM2 20211819 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P response to stimulus#GO:0050896;protein folding#GO:0006457;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein refolding#GO:0042026;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to heat#GO:0009408;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG113575|UniProtKB=T1EFU0 T1EFU0 20195442 PTHR48153:SF6 UFM1-SPECIFIC PROTEASE 2 UFM1-SPECIFIC PROTEASE 2 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG85680|UniProtKB=T1G615 T1G615 20216512 PTHR24333:SF13 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX DOMAIN-CONTAINING PROTEIN helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG93275|UniProtKB=T1G8U8 T1G8U8 20217495 PTHR11915:SF455 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ, SARCOMERIC-RELATED protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cell development#GO:0048468;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cell differentiation#GO:0030154;muscle cell differentiation#GO:0042692;cellular component organization#GO:0016043;muscle cell development#GO:0055001;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108 cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane#GO:0016020;Z disc#GO:0030018;cell periphery#GO:0071944;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoskeleton#GO:0005856;I band#GO:0031674;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HELRO|EnsemblGenome=HelroG179239|UniProtKB=T1FEE8 T1FEE8 20207197 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163064|UniProtKB=T1ETM1 T1ETM1 20199921 PTHR34587:SF2 VWFA DOMAIN-CONTAINING PROTEIN MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107622|UniProtKB=T1EEB7 T1EEB7 20194919 PTHR11254:SF429 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SU(DX) ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG72568|UniProtKB=T1G120 T1G120 20214768 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG107093|UniProtKB=T1EE74 T1EE74 20194876 PTHR24006:SF733 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12_46 HOMOLOG catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG158769|UniProtKB=T1EN88 T1EN88 20198038 PTHR10256:SF0 SELENIDE, WATER DIKINASE INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181889|UniProtKB=T1FHF6 T1FHF6 20208255 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170464|UniProtKB=T1F336 T1F336 20203235 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG81686|UniProtKB=T1G4H4 T1G4H4 20215972 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG164805|UniProtKB=T1EVU0 T1EVU0 20200690 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97933|UniProtKB=T1G9J6 T1G9J6 20217742 PTHR11799:SF12 PARAOXONASE PARAOXONASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG76435|UniProtKB=T1G2J8 T1G2J8 20215296 PTHR13703:SF45 SMAD SMAD FAMILY MEMBER 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 cellular response to growth factor stimulus#GO:0071363;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;cellular process#GO:0009987;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;response to growth factor#GO:0070848;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 SCW signaling pathway#P06216>MED#P06323;GBB signaling pathway#P06214>MED#P06299;TGF-beta signaling pathway#P00052>Co-Smads#P01276;DPP-SCW signaling pathway#P06212>MED#P06265;DPP signaling pathway#P06213>MED#P06279;MYO signaling pathway#P06215>MED#P06311;Activin beta signaling pathway#P06210>MED#P06233;TGF-beta signaling pathway#P00052>RSmads#P01292;BMP/activin signaling pathway-drosophila#P06211>Co-Smad#P06254;ALP23B signaling pathway#P06209>MED#P06221 HELRO|EnsemblGenome=HelroG192487|UniProtKB=T1FU06 T1FU06 20212302 PTHR12431:SF19 SORTING NEXIN 17 AND 27 SORTING NEXIN-27 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;metabolic process#GO:0008152;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;cellular localization#GO:0051641;macromolecule metabolic process#GO:0043170;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159024|UniProtKB=T1ENH7 T1ENH7 20198127 PTHR11324:SF16 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN 2 interleukin superfamily#PC00128;cytokine#PC00083 HELRO|EnsemblGenome=HelroG70625|UniProtKB=T1G094 T1G094 20214492 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG189106|UniProtKB=T1FQN7 T1FQN7 20211134 PTHR24399:SF87 ZINC FINGER AND BTB DOMAIN-CONTAINING C2H2-TYPE DOMAIN-CONTAINING PROTEIN transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG191669|UniProtKB=T1FT72 T1FT72 20212019 PTHR13293:SF6 AKIRIN-RELATED AKIRIN-RELATED transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of response to biotic stimulus#GO:0002831;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;regulation of gene expression#GO:0010468;positive regulation of response to biotic stimulus#GO:0002833;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of response to external stimulus#GO:0032103;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG105502|UniProtKB=T1EDV9 T1EDV9 20194761 PTHR12616:SF1 VACUOLAR PROTEIN SORTING VPS41 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;cellular response to starvation#GO:0009267;metabolic process#GO:0008152;intracellular transport#GO:0046907;cellular response to nutrient levels#GO:0031669;vacuolar transport#GO:0007034;transport#GO:0006810;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;macroautophagy#GO:0016236;organelle organization#GO:0006996;membrane fusion#GO:0061025;response to nutrient levels#GO:0031667;response to stress#GO:0006950;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;catabolic process#GO:0009056;response to stimulus#GO:0050896;vesicle fusion#GO:0006906;response to starvation#GO:0042594;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle tethering complex#GO:0099023;vacuolar membrane#GO:0005774;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG138724|UniProtKB=T1EIX1 T1EIX1 20196521 PTHR24333:SF13 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX DOMAIN-CONTAINING PROTEIN homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG163228|UniProtKB=T1ETT4 T1ETT4 20199984 PTHR10155:SF39 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING AT 16D, ISOFORM B protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG105985|UniProtKB=T1EDZ0 T1EDZ0 20194792 PTHR12644:SF5 ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cell migration#GO:0016477;cell motility#GO:0048870;cytoskeleton organization#GO:0007010 cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Integrin signalling pathway#P00034>Arp2/3#P00912 HELRO|EnsemblGenome=HelroG169073|UniProtKB=T1F1D2 T1F1D2 20202632 PTHR24161:SF128 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED PALMITOYLTRANSFERASE HIP14 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;neurotransmitter transport#GO:0006836;cell-cell signaling#GO:0007267;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulated exocytosis#GO:0045055;signaling#GO:0023052;export from cell#GO:0140352;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;secretion by cell#GO:0032940;cellular localization#GO:0051641;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;signal release#GO:0023061 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83529|UniProtKB=T1G567 T1G567 20216215 PTHR24031:SF91 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX24 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG190743|UniProtKB=T1FS91 T1FS91 20211688 PTHR11785:SF528 AMINO ACID TRANSPORTER LD25378P L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG176612|UniProtKB=T1FAQ5 T1FAQ5 20205904 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG177122|UniProtKB=T1FB91 T1FB91 20206090 PTHR46704:SF10 CXC DOMAIN-CONTAINING PROTEIN-RELATED TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80426|UniProtKB=T1G405 T1G405 20215803 PTHR13318:SF257 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX DOMAIN-CONTAINING PROTEIN proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HELRO|EnsemblGenome=HelroG169072|UniProtKB=T1F1D1 T1F1D1 20202631 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71969|UniProtKB=T1G0T7 T1G0T7 20214685 PTHR20971:SF0 U6 SNRNA-ASSOCIATED PROTEIN U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Lsm2-8 complex#GO:0120115;spliceosomal snRNP complex#GO:0097525;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U6 snRNP#GO:0005688;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG169226|UniProtKB=T1F1L5 T1F1L5 20202715 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167918|UniProtKB=T1EZY6 T1EZY6 20202136 PTHR24249:SF422 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG160635|UniProtKB=T1EQJ1 T1EQJ1 20198841 PTHR16290:SF0 TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1 DECAPPING PROTEIN 1, ISOFORM A binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA catabolic process#GO:0006401;RNA decapping#GO:0110154;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 mRNA capping factor#PC00145;RNA processing factor#PC00147 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG193202|UniProtKB=T1FUR0 T1FUR0 20212556 PTHR23107:SF0 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN IP09280P transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG102781|UniProtKB=T1EDB7 T1EDB7 20194569 PTHR23088:SF27 NITRILASE-RELATED DEAMINATED GLUTATHIONE AMIDASE hydrolase#PC00121 HELRO|EnsemblGenome=HelroG167104|UniProtKB=T1EZ09 T1EZ09 20201809 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164773|UniProtKB=T1EVS8 T1EVS8 20200678 PTHR23048:SF66 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN 2 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG80106|UniProtKB=T1G3X8 T1G3X8 20215776 PTHR12834:SF12 SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein targeting to membrane#GO:0006612;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;localization within membrane#GO:0051668;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047 ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG67498|UniProtKB=T1FZ19 T1FZ19 20214067 PTHR13617:SF14 PROTEIN ABHD18 CARDIOLIPIN-SPECIFIC DEACYLASE, MITOCHONDRIAL hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;lipase activity#GO:0016298 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG193569|UniProtKB=T1FV49 T1FV49 20212695 PTHR15885:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 174 COILED-COIL DOMAIN-CONTAINING PROTEIN 174 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG189501|UniProtKB=T1FR39 T1FR39 20211286 PTHR11227:SF17 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED AUTOPHAGY-RELATED 18A, ISOFORM E lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090 autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;process utilizing autophagic mechanism#GO:0061919;carbohydrate catabolic process#GO:0016052;glucan catabolic process#GO:0009251;polysaccharide metabolic process#GO:0005976;polysaccharide catabolic process#GO:0000272;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;energy derivation by oxidation of organic compounds#GO:0015980;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;generation of precursor metabolites and energy#GO:0006091;autophagy of mitochondrion#GO:0000422;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;glycogen catabolic process#GO:0005980;vacuole organization#GO:0007033;localization#GO:0051179;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977 membrane#GO:0016020;phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181765|UniProtKB=T1FHA9 T1FHA9 20208208 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG91681|UniProtKB=T1G878 T1G878 20217275 PTHR11834:SF0 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED PROTEIN SCALLOPED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG178850|UniProtKB=T1FDT7 T1FDT7 20206986 PTHR24198:SF203 ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN SOCS BOX DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG194575|UniProtKB=T1FW76 T1FW76 20213072 PTHR15160:SF17 VON HIPPEL-LINDAU PROTEIN VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR ubiquitin-like ligase-substrate adaptor activity#GO:1990756;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;enzyme-substrate adaptor activity#GO:0140767 modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of RNA metabolic process#GO:0051252;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Hypoxia response via HIF activation#P00030>VHL#P00816 HELRO|EnsemblGenome=HelroG184120|UniProtKB=T1FKM3 T1FKM3 20209372 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177430|UniProtKB=T1FBP3 T1FBP3 20206242 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG180810|UniProtKB=T1FGB1 T1FGB1 20207860 PTHR16019:SF6 SYNAPSE-ASSOCIATED PROTEIN SYNAPSE-ASSOCIATED PROTEIN 1 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;positive regulation of fat cell differentiation#GO:0045600;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;signaling#GO:0023052;TORC2 signaling#GO:0038203;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;biological regulation#GO:0065007;TOR signaling#GO:0031929;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;synapse#GO:0045202;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG182769|UniProtKB=T1FIP7 T1FIP7 20208696 PTHR46652:SF7 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 42 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76173|UniProtKB=T1G2G2 T1G2G2 20215260 PTHR22779:SF6 SD17342P SD17342P HELRO|EnsemblGenome=HelroG184476|UniProtKB=T1FLA2 T1FLA2 20209601 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184857|UniProtKB=T1FM33 T1FM33 20209882 PTHR12277:SF194 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN FI04476P lipase activity#GO:0016298;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787 lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerophospholipid catabolic process#GO:0046475;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 serine protease#PC00203 HELRO|EnsemblGenome=HelroG188738|UniProtKB=T1FQB4 T1FQB4 20211011 PTHR13161:SF4 SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG155178|UniProtKB=T1ELH5 T1ELH5 20197425 PTHR16317:SF2 INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING INTEGRIN ALPHA FG-GAP REPEAT CONTAINING 2 integrin#PC00126 HELRO|EnsemblGenome=HelroG175609|UniProtKB=T1F9F3 T1F9F3 20205452 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG90867|UniProtKB=T1G7X1 T1G7X1 20217168 PTHR45837:SF3 VESICLE-TRAFFICKING PROTEIN SEC22B VESICLE-TRAFFICKING PROTEIN SEC22B SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;membrane fusion#GO:0061025;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179 intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;intracellular vesicle#GO:0097708;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane protein complex#GO:0098796;vesicle#GO:0031982;SNARE complex#GO:0031201;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;ER to Golgi transport vesicle membrane#GO:0012507;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG79470|UniProtKB=T1G3P1 T1G3P1 20215689 PTHR11071:SF593 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG176785|UniProtKB=T1FAW8 T1FAW8 20205967 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG172114|UniProtKB=T1F517 T1F517 20203916 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164065|UniProtKB=T1EUV1 T1EUV1 20200351 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG131255|UniProtKB=T1EHV6 T1EHV6 20196156 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;response to fibroblast growth factor#GO:0071774;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG186068|UniProtKB=T1FNM4 T1FNM4 20210421 PTHR10660:SF2 PROTEASOME REGULATOR PA28 LD45860P peptidase regulator activity#GO:0061134;peptidase activator activity#GO:0016504;endopeptidase regulator activity#GO:0061135;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of protein catabolic process#GO:0042176;regulation of cell cycle phase transition#GO:1901987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of mitotic cell cycle#GO:0007346;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG177514|UniProtKB=T1FBT9 T1FBT9 20206288 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79233|UniProtKB=T1G3L7 T1G3L7 20215665 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 transferase#PC00220 HELRO|EnsemblGenome=HelroG72173|UniProtKB=T1G0W7 T1G0W7 20214715 PTHR12910:SF2 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75660|UniProtKB=T1G285 T1G285 20215183 PTHR43340:SF1 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;metal ion binding#GO:0046872;magnesium ion binding#GO:0000287;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;pentosyltransferase activity#GO:0016763 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;IMP biosynthetic process#GO:0006188;organophosphate biosynthetic process#GO:0090407;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;purine nucleobase metabolic process#GO:0006144;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 Xanthine and guanine salvage pathway#P02788>Guanine phosphoribosyl transferase#P03245;Adenine and hypoxanthine salvage pathway#P02723>Hypoxanthine phosphoribosyl transferase#P02804;Xanthine and guanine salvage pathway#P02788>Xanthine phosphoribosyl transferase#P03247;Salvage pyrimidine ribonucleotides#P02775>Uracil phosphoribosyl transferase#P03151 HELRO|EnsemblGenome=HelroG155821|UniProtKB=T1ELM7 T1ELM7 20197477 PTHR11001:SF2 MITOCHONDRIAL FISSION PROCESS PROTEIN 1 MITOCHONDRIAL FISSION PROCESS PROTEIN 1 organelle fission#GO:0048285;cellular component organization or biogenesis#GO:0071840;mitochondrial fission#GO:0000266;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG183940|UniProtKB=T1FKB8 T1FKB8 20209267 PTHR15681:SF1 MAD2L1-BINDING PROTEIN MAD2L1-BINDING PROTEIN intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG155577|UniProtKB=T1ELJ0 T1ELJ0 20197440 PTHR45703:SF8 DYNEIN HEAVY CHAIN AAA+ ATPASE DOMAIN-CONTAINING PROTEIN microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG84000|UniProtKB=T1G5D0 T1G5D0 20216277 PTHR24353:SF160 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;cell adhesion#GO:0007155;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;serine/threonine protein kinase complex#GO:1902554;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;GABA-B receptor II signaling#P05731>PKA#P05752;Endothelin signaling pathway#P00019>PKA#P00570;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862 HELRO|EnsemblGenome=HelroG193367|UniProtKB=T1FUX3 T1FUX3 20212619 PTHR36911:SF3 LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 4-RELATED HELRO|EnsemblGenome=HelroG89746|UniProtKB=T1G7H1 T1G7H1 20217018 PTHR32315:SF3 ADENINE PHOSPHORIBOSYLTRANSFERASE ADENINE PHOSPHORIBOSYLTRANSFERASE cation binding#GO:0043169;pentosyltransferase activity#GO:0016763;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;transferase activity#GO:0016740 organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleobase metabolic process#GO:0006144;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 Adenine and hypoxanthine salvage pathway#P02723>Adenine phosphoribosyl transferase#P02810 HELRO|EnsemblGenome=HelroG181843|UniProtKB=T1FHE2 T1FHE2 20208241 PTHR12514:SF1 ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR TRANSCRIPTION AND MRNA EXPORT FACTOR ENY2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;metabolic process#GO:0008152;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;nucleocytoplasmic transport#GO:0006913;nucleic acid transport#GO:0050657;regulation of DNA-templated transcription#GO:0006355;localization#GO:0051179;regulation of RNA metabolic process#GO:0051252;nuclear export#GO:0051168;nuclear transport#GO:0051169;RNA localization#GO:0006403;regulation of cellular process#GO:0050794;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;regulation of macromolecule metabolic process#GO:0060255;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nitrogen compound transport#GO:0071705;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transcription export complex 2#GO:0070390;chromosome#GO:0005694;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;SAGA complex#GO:0000124;DUBm complex#GO:0071819;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG164897|UniProtKB=T1EVX9 T1EVX9 20200729 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100932|UniProtKB=T1ED20 T1ED20 20194472 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HELRO|EnsemblGenome=HelroG173143|UniProtKB=T1F6G2 T1F6G2 20204411 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168227|UniProtKB=T1F0C1 T1F0C1 20202271 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183756|UniProtKB=T1FK56 T1FK56 20209205 PTHR46164:SF3 ATF6, ISOFORM C ATF6, ISOFORM C transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;response to unfolded protein#GO:0006986;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383 HELRO|EnsemblGenome=HelroG79798|UniProtKB=T1G3T4 T1G3T4 20215732 PTHR24637:SF437 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188490|UniProtKB=T1FQ18 T1FQ18 20210915 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180291|UniProtKB=T1FFP5 T1FFP5 20207644 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272 cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG159084|UniProtKB=T1ENK4 T1ENK4 20198154 PTHR21676:SF8 PROTEIN STUM PROTEIN STUM multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;taxis#GO:0042330;locomotion#GO:0040011;nervous system process#GO:0050877;sensory perception#GO:0007600;neuromuscular process#GO:0050905;sensory perception of mechanical stimulus#GO:0050954;system process#GO:0003008;response to external stimulus#GO:0009605 dendritic tree#GO:0097447;neuron projection#GO:0043005;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG74642|UniProtKB=T1G1T5 T1G1T5 20215033 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG178204|UniProtKB=T1FCX9 T1FCX9 20206678 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70637|UniProtKB=T1G097 T1G097 20214495 PTHR24073:SF263 DRAB5-RELATED RAB-LIKE PROTEIN 2A-RELATED hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG128920|UniProtKB=T1EHQ9 T1EHQ9 20196109 PTHR11849:SF282 ETS ETV5-RELATED PROTEIN ETS96B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG194580|UniProtKB=T1FW78 T1FW78 20213074 PTHR24083:SF189 NUCLEAR HORMONE RECEPTOR PROTEIN TAILLESS sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677 developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG159552|UniProtKB=T1EP55 T1EP55 20198355 PTHR22655:SF2 ATP-DEPENDENT RNA HELICASE TDRD12-RELATED ATP-DEPENDENT RNA HELICASE TDRD12-RELATED nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;piRNA processing#GO:0034587;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG85778|UniProtKB=T1G628 T1G628 20216525 PTHR45905:SF1 GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267 vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization within membrane#GO:0051668;vesicle-mediated transport#GO:0016192;Golgi to plasma membrane transport#GO:0006893;cellular process#GO:0009987;macromolecule localization#GO:0033036 Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HELRO|EnsemblGenome=HelroG194479|UniProtKB=T1FW37 T1FW37 20213033 PTHR16017:SF0 GASTRULATION DEFECTIVE PROTEIN 1-RELATED WD REPEAT-CONTAINING PROTEIN 70 site of double-strand break#GO:0035861;chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG128997|UniProtKB=T1EHR2 T1EHR2 20196112 PTHR10217:SF637 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL EAG-LIKE K[+] CHANNEL, ISOFORM A voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG73313|UniProtKB=T1G1C8 T1G1C8 20214876 PTHR24208:SF168 LIM/HOMEOBOX PROTEIN LHX PROTEIN APTEROUS sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG156430|UniProtKB=T1ELW5 T1ELW5 20197565 PTHR13180:SF4 SMALL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 50A localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506 HELRO|EnsemblGenome=HelroG74448|UniProtKB=T1G1R3 T1G1R3 20215011 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;non-membrane spanning protein tyrosine kinase activity#GO:0004715;signaling receptor binding#GO:0005102;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;developmental process#GO:0032502 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG108507|UniProtKB=T1EEJ6 T1EEJ6 20194998 PTHR10807:SF73 MYOTUBULARIN-RELATED LD06050P phosphoric ester hydrolase activity#GO:0042578;protein phosphatase binding#GO:0019903;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein binding#GO:0005515;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894;lipid modification#GO:0030258;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;phosphate-containing compound metabolic process#GO:0006796;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;negative regulation of metabolic process#GO:0009892;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;phosphatidylinositol dephosphorylation#GO:0046856;negative regulation of catabolic process#GO:0009895;dephosphorylation#GO:0016311 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG163981|UniProtKB=T1EUQ0 T1EUQ0 20200300 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182160|UniProtKB=T1FHU6 T1FHU6 20208395 PTHR23189:SF137 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN SPENITO nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG112911|UniProtKB=T1EFN3 T1EFN3 20195385 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;purine nucleoside metabolic process#GO:0042278;purine-containing compound biosynthetic process#GO:0072522;nucleoside catabolic process#GO:0009164;cellular process#GO:0009987;adenosine metabolic process#GO:0046085;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;small molecule biosynthetic process#GO:0044283;purine nucleobase metabolic process#GO:0006144;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase metabolic process#GO:0009112;purine nucleoside catabolic process#GO:0006152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;purine-containing compound catabolic process#GO:0072523 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cytosol#GO:0005829 deaminase#PC00088 HELRO|EnsemblGenome=HelroG181795|UniProtKB=T1FHC2 T1FHC2 20208221 PTHR13248:SF4 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 ELONGIN-B transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional gene silencing#GO:0016441;protein metabolic process#GO:0019538;positive regulation of biosynthetic process#GO:0009891;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;proteasomal protein catabolic process#GO:0010498;positive regulation of macromolecule metabolic process#GO:0010604;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 Cul3-RING ubiquitin ligase complex#GO:0031463;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;Cul2-RING ubiquitin ligase complex#GO:0031462;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG189762|UniProtKB=T1FRC7 T1FRC7 20211374 PTHR12363:SF42 TRANSPORTIN 3 AND IMPORTIN 13 TRANSPORTIN-3 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967 transporter#PC00227 HELRO|EnsemblGenome=HelroG70687|UniProtKB=T1G0A7 T1G0A7 20214505 PTHR45894:SF1 RNA-BINDING PROTEIN 8A RNA-BINDING PROTEIN 8A mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exon-exon junction complex#GO:0035145;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG189220|UniProtKB=T1FQT4 T1FQT4 20211181 PTHR46077:SF1 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG159622|UniProtKB=T1EP91 T1EP91 20198391 PTHR13136:SF16 TESTIS DEVELOPMENT PROTEIN PRTD KAT8 REGULATORY NSL COMPLEX SUBUNIT 3 positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;NSL complex#GO:0044545;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG182276|UniProtKB=T1FI08 T1FI08 20208457 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG179324|UniProtKB=T1FEJ7 T1FEJ7 20207246 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG111473|UniProtKB=T1EFB5 T1EFB5 20195267 PTHR45639:SF3 HSC70CB, ISOFORM G-RELATED HYPOXIA UP-REGULATED PROTEIN 1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072;Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG185727|UniProtKB=T1FN74 T1FN74 20210272 PTHR12737:SF9 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE GM09012P hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;biological regulation#GO:0065007;oxoacid metabolic process#GO:0043436;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;small molecule metabolic process#GO:0044281 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG108224|UniProtKB=T1EEH1 T1EEH1 20194973 PTHR47330:SF1 POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED POLY(U)-BINDING-SPLICING FACTOR PUF60 spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;alternative mRNA splicing, via spliceosome#GO:0000380;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;regulation of mRNA splicing, via spliceosome#GO:0048024;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG84240|UniProtKB=T1G5G2 T1G5G2 20216309 PTHR21100:SF9 PREFOLDIN SUBUNIT 4 PREFOLDIN SUBUNIT 4 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176023|UniProtKB=T1FA13 T1FA13 20205662 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164009|UniProtKB=T1EUR5 T1EUR5 20200315 PTHR43092:SF4 L-CYSTEINE DESULFHYDRASE AMINOTRANSFERASE CLASS V DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846 biosynthetic process#GO:0009058;cellular process#GO:0009987;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575 lyase#PC00144 HELRO|EnsemblGenome=HelroG98699|UniProtKB=T1G9P4 T1G9P4 20217790 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Enkephalin release#P05913>PKA#P05972 HELRO|EnsemblGenome=HelroG190637|UniProtKB=T1FS58 T1FS58 20211655 PTHR13025:SF6 EF-HAND DOMAIN-CONTAINING PROTEIN D EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG183886|UniProtKB=T1FKA4 T1FKA4 20209253 PTHR20948:SF2 TRANSMEMBRANE PROTEIN 164 RH09039P HELRO|EnsemblGenome=HelroG180750|UniProtKB=T1FG85 T1FG85 20207834 PTHR10293:SF74 GLUTAREDOXIN FAMILY MEMBER GLUTAREDOXIN-3 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;cellular component organization or biogenesis#GO:0071840;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;cellular component assembly#GO:0022607;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;cellular component biogenesis#GO:0044085;inorganic ion homeostasis#GO:0098771;iron-sulfur cluster assembly#GO:0016226;homeostatic process#GO:0042592;intracellular iron ion homeostasis#GO:0006879;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190941|UniProtKB=T1FSG0 T1FSG0 20211757 PTHR10306:SF17 SYNAPTOPHYSIN MARVEL DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;presynapse#GO:0098793;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG185654|UniProtKB=T1FN34 T1FN34 PTHR15735:SF12 FCH AND DOUBLE SH3 DOMAINS PROTEIN CDC42-INTERACTING PROTEIN 4, ISOFORM B regulation of actin filament-based process#GO:0032970;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;biological regulation#GO:0065007;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG179787|UniProtKB=T1FF57 T1FF57 20207456 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG182714|UniProtKB=T1FIM7 T1FIM7 20208676 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171157|UniProtKB=T1F3V9 T1F3V9 20203508 PTHR15561:SF0 CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG67123|UniProtKB=T1FYW7 T1FYW7 20214015 PTHR19957:SF435 SYNTAXIN HL02043P molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;vesicle organization#GO:0016050;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;presynapse#GO:0098793;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;synapse#GO:0045202;organelle#GO:0043226;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG85402|UniProtKB=T1G5W5 T1G5W5 20216462 PTHR13345:SF13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG189402|UniProtKB=T1FR11 T1FR11 20211258 PTHR11388:SF100 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER transporter#PC00227 HELRO|EnsemblGenome=HelroG69512|UniProtKB=T1FZW3 T1FZW3 20214361 PTHR46346:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220 HELRO|EnsemblGenome=HelroG184057|UniProtKB=T1FKI0 T1FKI0 20209329 PTHR11782:SF127 ADENOSINE/GUANOSINE DIPHOSPHATASE NUCLEOSIDE DIPHOSPHATE PHOSPHATASE hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate catabolic process#GO:0046434;nucleoside diphosphate metabolic process#GO:0009132;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181;nucleotide phosphatase#PC00173;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG153345|UniProtKB=T1EL46 T1EL46 20197296 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161907|UniProtKB=T1ES11 T1ES11 20199361 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG111692|UniProtKB=T1EFD7 T1EFD7 20195289 PTHR22961:SF16 SER/THR PROTEIN KINASE-TRB SERINE_THREONINE-PROTEIN KINASE 40 regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of MAPK cascade#GO:0043408;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185372|UniProtKB=T1FMQ6 T1FMQ6 20210105 PTHR43602:SF1 FAMILY NOT NAMED ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG105761|UniProtKB=T1EDX3 T1EDX3 20194775 PTHR11157:SF126 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 oxoacid metabolic process#GO:0043436;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG164161|UniProtKB=T1EV08 T1EV08 20200408 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190953|UniProtKB=T1FSG4 T1FSG4 20211761 PTHR11932:SF174 CULLIN CULLIN-2 ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;protein binding#GO:0005515;enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488 protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG130545|UniProtKB=T1EHU2 T1EHU2 20196142 PTHR23071:SF1 PHOSPHATIDYLINOSITOL GLYCAN GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3, CATALYTIC SUBUNIT phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79229|UniProtKB=T1G3L5 T1G3L5 20215663 PTHR14140:SF45 E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein ubiquitination#GO:0016567;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG189278|UniProtKB=T1FQW8 T1FQW8 20211215 PTHR24343:SF540 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE CHK1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;histone kinase activity#GO:0035173 cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;mitotic G2/M transition checkpoint#GO:0044818;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG174349|UniProtKB=T1F812 T1F812 20204961 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74545|UniProtKB=T1G1S5 T1G1S5 20215023 PTHR12645:SF0 ALR/ERV SULFHYDRYL OXIDASE protein-disulfide reductase activity#GO:0015035;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;nucleotide binding#GO:0000166;disulfide oxidoreductase activity#GO:0015036;heterocyclic compound binding#GO:1901363;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;oxidase#PC00175 HELRO|EnsemblGenome=HelroG95450|UniProtKB=T1G960 T1G960 20217607 PTHR18966:SF602 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023 cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell communication#GO:0007154;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HELRO|EnsemblGenome=HelroG85991|UniProtKB=T1G657 T1G657 20216554 PTHR10460:SF68 ABL INTERACTOR FAMILY MEMBER ABELSON INTERACTING PROTEIN, ISOFORM D signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 developmental process#GO:0032502;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular developmental process#GO:0048869;neuron migration#GO:0001764;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cell migration#GO:0016477;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell motility#GO:0048870;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cell leading edge#GO:0031252;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;organelle#GO:0043226;lamellipodium#GO:0030027;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155844|UniProtKB=T1ELN2 T1ELN2 20197482 PTHR45896:SF1 N-ALPHA-ACETYLTRANSFERASE 30 N-ALPHA-ACETYLTRANSFERASE 30 catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG159026|UniProtKB=T1ENH8 T1ENH8 20198128 PTHR13024:SF0 MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN lipoprotein metabolic process#GO:0042157;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 basal part of cell#GO:0045178;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 transporter#PC00227 HELRO|EnsemblGenome=HelroG166439|UniProtKB=T1EY49 T1EY49 20201499 PTHR23338:SF16 SMALL NUCLEAR RIBONUCLEOPROTEIN SM U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4 binding#GO:0005488;nucleic acid binding#GO:0003676;snRNA binding#GO:0017069;RNA binding#GO:0003723 RNA splicing, via transesterification reactions#GO:0000375;organelle assembly#GO:0070925;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;P-body assembly#GO:0033962;spliceosomal snRNP assembly#GO:0000387;RNA biosynthetic process#GO:0032774;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;U6 snRNP#GO:0005688;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;P-body#GO:0000932 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG112906|UniProtKB=T1EFN2 T1EFN2 20195384 PTHR11941:SF171 ENOYL-COA HYDRATASE-RELATED SD19268P lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 lipid modification#GO:0030258;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 hydratase#PC00120;lyase#PC00144;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG109943|UniProtKB=T1EEX6 T1EEX6 20195128 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG173066|UniProtKB=T1F6B3 T1F6B3 20204362 PTHR12059:SF5 RIBOSOMAL PROTEIN L23-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;metabolic process#GO:0008152;translation#GO:0006412 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG189823|UniProtKB=T1FRE3 T1FRE3 20211390 PTHR23238:SF26 RNA BINDING PROTEIN GH13594P-RELATED transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162055|UniProtKB=T1ES72 T1ES72 20199422 PTHR37162:SF15 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111863|UniProtKB=T1EFF2 T1EFF2 20195304 PTHR24384:SF189 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG83384|UniProtKB=T1G550 T1G550 20216198 PTHR48416:SF1 CYTOCHROME C OXIDASE SUBUNIT 6C CYTOCHROME C OXIDASE SUBUNIT 6C mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165838|UniProtKB=T1EXC5 T1EXC5 20201225 PTHR12692:SF8 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED GH11935P metal ion transport#GO:0030001;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;protein metabolic process#GO:0019538;transmembrane transport#GO:0055085;monoatomic cation transmembrane transport#GO:0098655;biosynthetic process#GO:0009058;monoatomic ion transmembrane transport#GO:0034220;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;transport#GO:0006810;metabolic process#GO:0008152;magnesium ion transport#GO:0015693 endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG73944|UniProtKB=T1G1K5 T1G1K5 20214953 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG105256|UniProtKB=T1EDS4 T1EDS4 20194726 PTHR10972:SF200 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9 sterol binding#GO:0032934;binding#GO:0005488;steroid binding#GO:0005496;lipid binding#GO:0008289 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;membrane#GO:0016020 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG91190|UniProtKB=T1G810 T1G810 20217207 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG183438|UniProtKB=T1FJN4 T1FJN4 20209033 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG175105|UniProtKB=T1F8V0 T1F8V0 20205249 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191433|UniProtKB=T1FSZ2 T1FSZ2 20211939 PTHR31395:SF26 SHISA GEO05642P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174608|UniProtKB=T1F8A8 T1F8A8 20205057 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG106963|UniProtKB=T1EE63 T1EE63 20194865 PTHR10110:SF98 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG62880|UniProtKB=T1FX65 T1FX65 20213413 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG178965|UniProtKB=T1FDZ5 T1FDZ5 20207044 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG168451|UniProtKB=T1F0L8 T1F0L8 20202368 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG72768|UniProtKB=T1G153 T1G153 20214801 PTHR21236:SF2 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF cellular component organization#GO:0016043;Golgi organization#GO:0007030;vesicle fusion#GO:0006906;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle organization#GO:0006996;membrane fusion#GO:0061025;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050 Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 structural protein#PC00211 HELRO|EnsemblGenome=HelroG164740|UniProtKB=T1EVR6 T1EVR6 20200666 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189592|UniProtKB=T1FR65 T1FR65 20211312 PTHR48209:SF4 AGL056WP C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG120427|UniProtKB=T1EGP9 T1EGP9 20195749 PTHR13906:SF4 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 6 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid modification#GO:0030258;primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG176074|UniProtKB=T1FA41 T1FA41 20205690 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG175489|UniProtKB=T1F9B5 T1F9B5 20205414 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG176399|UniProtKB=T1FAH3 T1FAH3 20205822 PTHR44314:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70 cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium movement#GO:0003341;organelle assembly#GO:0070925;cilium organization#GO:0044782 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165 structural protein#PC00211 HELRO|EnsemblGenome=HelroG99479|UniProtKB=T1G9T0 T1G9T0 20217826 PTHR14463:SF5 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 2 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183252|UniProtKB=T1FJD6 T1FJD6 20208935 PTHR24410:SF51 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG176894|UniProtKB=T1FB11 T1FB11 20206010 PTHR24026:SF141 FAT ATYPICAL CADHERIN-RELATED CADHERIN DOMAIN-CONTAINING PROTEIN neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;axon development#GO:0061564;neuron projection development#GO:0031175 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG183366|UniProtKB=T1FJI6 T1FJI6 20208985 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 steroid hydroxylase activity#GO:0008395;binding#GO:0005488;tetrapyrrole binding#GO:0046906;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;response to chemical#GO:0042221;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG115988|UniProtKB=T1EGC4 T1EGC4 20195626 PTHR10693:SF88 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN AT27578P RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoplasmic stress granule assembly#GO:0034063;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytosol#GO:0005829 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG173125|UniProtKB=T1F6E6 T1F6E6 20204395 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG173490|UniProtKB=T1F6V8 T1F6V8 20204557 PTHR31395:SF25 SHISA PROTEIN SHISA-5-LIKE ISOFORM X1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173198|UniProtKB=T1F6J6 T1F6J6 20204445 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111783|UniProtKB=T1EFE5 T1EFE5 20195297 PTHR23281:SF18 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;cell adhesion molecule binding#GO:0050839 regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of anatomical structure morphogenesis#GO:0022603;biological regulation#GO:0065007;regulation of organelle assembly#GO:1902115;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050 adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;filopodium#GO:0030175;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG186066|UniProtKB=T1FNM3 T1FNM3 20210420 PTHR12611:SF0 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG71169|UniProtKB=T1G0H3 T1G0H3 20214571 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG71735|UniProtKB=T1G0R0 T1G0R0 20214658 PTHR11080:SF35 PYRAZINAMIDASE/NICOTINAMIDASE NICOTINAMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;amidase activity#GO:0004040 metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG162029|UniProtKB=T1ES57 T1ES57 20199407 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG70775|UniProtKB=T1G0C0 T1G0C0 20214518 PTHR13439:SF4 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;membrane organization#GO:0061024;homeostatic process#GO:0042592;cellular component organization#GO:0016043;lipid homeostasis#GO:0055088;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;membrane assembly#GO:0071709;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;regulation of membrane lipid distribution#GO:0097035;regulation of biological quality#GO:0065008;chemical homeostasis#GO:0048878 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG75911|UniProtKB=T1G2C5 T1G2C5 20215223 PTHR24115:SF1025 KINESIN-RELATED KINESIN HEAVY CHAIN ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657 microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;organelle localization#GO:0051640;axonal transport#GO:0098930;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;anterograde axonal transport#GO:0008089;synaptic vesicle transport#GO:0048489;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;synaptic vesicle localization#GO:0097479;cytoskeleton-dependent intracellular transport#GO:0030705;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG66168|UniProtKB=T1FYH9 T1FYH9 20213877 PTHR14097:SF7 OXIDOREDUCTASE HTATIP2 PROTEIN HTATIP2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185224|UniProtKB=T1FMJ1 T1FMJ1 20210040 PTHR44279:SF2 HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG66475|UniProtKB=T1FYL6 T1FYL6 20213914 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK-1 catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG97596|UniProtKB=T1G9H8 T1G9H8 20217725 PTHR10075:SF100 BASIGIN RELATED PROTEIN SAX-3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG165102|UniProtKB=T1EWA8 T1EWA8 20200858 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG174541|UniProtKB=T1F885 T1F885 20205034 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG74186|UniProtKB=T1G1N2 T1G1N2 20214980 PTHR24348:SF64 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE DDB_G0278901-RELATED protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG177213|UniProtKB=T1FBD1 T1FBD1 20206130 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG185424|UniProtKB=T1FMT1 T1FMT1 20210130 PTHR18860:SF184 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA scaffold/adaptor protein#PC00226 PI3 kinase pathway#P00048>14-3-3#P01206;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624;Parkinson disease#P00049>14-3-3#P01238 HELRO|EnsemblGenome=HelroG76784|UniProtKB=T1G2P5 T1G2P5 20215343 PTHR11849:SF302 ETS ETS DOMAIN-CONTAINING PROTEIN-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG113916|UniProtKB=T1EFX4 T1EFX4 20195476 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 cellular process#GO:0009987;amino acid transport#GO:0006865;transport#GO:0006810;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG103156|UniProtKB=T1EDE5 T1EDE5 20194597 PTHR20930:SF10 OVARIAN CARCINOMA ANTIGEN CA125-RELATED PROTEIN ILRUN intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;establishment of protein localization to organelle#GO:0072594;regulation of gene expression#GO:0010468;intracellular protein localization#GO:0008104;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605;macroautophagy#GO:0016236;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;protein localization to vacuole#GO:0072665;localization#GO:0051179;negative regulation of multicellular organismal process#GO:0051241;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;regulation of localization#GO:0032879;protein targeting to vacuole#GO:0006623;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;regulation of multicellular organismal process#GO:0051239;cellular localization#GO:0051641;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;regulation of protein localization#GO:0032880;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666;negative regulation of metabolic process#GO:0009892 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cytosol#GO:0005829;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG126215|UniProtKB=T1EH88 T1EH88 20195938 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HELRO|EnsemblGenome=HelroG140484|UniProtKB=T1EJ12 T1EJ12 20196562 PTHR21208:SF1 ADP-DEPENDENT GLUCOKINASE ADP-DEPENDENT GLUCOKINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;glucose metabolic process#GO:0006006;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 kinase#PC00137 HELRO|EnsemblGenome=HelroG183649|UniProtKB=T1FJZ7 T1FJZ7 20209146 PTHR31802:SF47 32 KDA HEAT SHOCK PROTEIN-RELATED TELOMERE_REG-2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185780|UniProtKB=T1FNA2 T1FNA2 20210299 PTHR21136:SF179 SNARE PROTEINS VESICLE-ASSOCIATED MEMBRANE PROTEIN 7 protein binding#GO:0005515;SNAP receptor activity#GO:0005484;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488 localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;endosome to lysosome transport#GO:0008333;organelle localization#GO:0051640;localization#GO:0051179;secretion#GO:0046903;Golgi organization#GO:0007030;protein localization to plasma membrane#GO:0072659;vesicle fusion#GO:0006906;Golgi to plasma membrane transport#GO:0006893;catabolic process#GO:0009056;microtubule-based movement#GO:0007018;vacuolar transport#GO:0007034;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;phagocytosis#GO:0006909;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;vesicle cytoskeletal trafficking#GO:0099518;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;vesicle localization#GO:0051648;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;membrane organization#GO:0061024;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;lysosomal transport#GO:0007041;post-Golgi vesicle-mediated transport#GO:0006892;secretion by cell#GO:0032940;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;export from cell#GO:0140352;Golgi to plasma membrane protein transport#GO:0043001;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;membrane invagination#GO:0010324;Golgi vesicle transport#GO:0048193;protein localization to cell periphery#GO:1990778;metabolic process#GO:0008152;exocytosis#GO:0006887;vesicle organization#GO:0016050;microtubule-based process#GO:0007017;phagocytosis, engulfment#GO:0006911;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;endomembrane system organization#GO:0010256;establishment of vesicle localization#GO:0051650;organelle membrane fusion#GO:0090174;organelle transport along microtubule#GO:0072384;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192 membrane#GO:0016020;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane traffic protein#PC00150;SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG178197|UniProtKB=T1FCX4 T1FCX4 20206673 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182201|UniProtKB=T1FHX2 T1FHX2 20208421 PTHR15036:SF88 PIKACHURIN-LIKE PROTEIN PIKACHURIN multicellular organism development#GO:0007275;developmental process#GO:0032502;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012;basement membrane#GO:0005604;cell periphery#GO:0071944;cell junction#GO:0030054;extracellular region#GO:0005576 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG168626|UniProtKB=T1F0T2 T1F0T2 20202432 PTHR48527:SF1 BA1-665 BA1-665 HELRO|EnsemblGenome=HelroG169612|UniProtKB=T1F260 T1F260 20202910 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD CASPASE DRONC positive regulation of apoptotic process#GO:0043065;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162392|UniProtKB=T1ESL5 T1ESL5 20199565 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116230|UniProtKB=T1EGD6 T1EGD6 20195638 PTHR13096:SF8 MINA53 MYC INDUCED NUCLEAR ANTIGEN RIBOSOMAL OXYGENASE 1 dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;protein demethylase activity#GO:0140457;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG183155|UniProtKB=T1FJ81 T1FJ81 20208880 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177750|UniProtKB=T1FC69 T1FC69 20206418 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173054|UniProtKB=T1F6A9 T1F6A9 20204358 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163706|UniProtKB=T1EUD6 T1EUD6 20200186 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170504|UniProtKB=T1F351 T1F351 20203250 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG165025|UniProtKB=T1EW58 T1EW58 20200808 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG70217|UniProtKB=T1G035 T1G035 20214433 PTHR45829:SF4 MITOCHONDRIAL CARRIER PROTEIN RIM2 MITOCHONDRIAL CARRIER PROTEIN RIM2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HELRO|EnsemblGenome=HelroG113667|UniProtKB=T1EFU9 T1EFU9 20195451 PTHR24058:SF12 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191853|UniProtKB=T1FTC9 T1FTC9 20212076 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 FGF signaling pathway#P00021>RKIP#P00630;EGF receptor signaling pathway#P00018>RKIP#P00548 HELRO|EnsemblGenome=HelroG105252|UniProtKB=T1EDS3 T1EDS3 20194725 PTHR12433:SF11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG83597|UniProtKB=T1G579 T1G579 20216227 PTHR45682:SF5 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG187231|UniProtKB=T1FP79 T1FP79 20210626 PTHR11223:SF2 EXPORTIN 1/5 EXPORTIN-1 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 ribosomal large subunit export from nucleus#GO:0000055;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;organelle localization#GO:0051640;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG184655|UniProtKB=T1FLP4 T1FLP4 20209743 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160345|UniProtKB=T1EQ45 T1EQ45 20198695 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164483|UniProtKB=T1EVH5 T1EVH5 20200575 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175278|UniProtKB=T1F935 T1F935 20205334 PTHR28607:SF4 EXPRESSED PROTEIN MEMBRANE PROTEIN FAM174-LIKE HELRO|EnsemblGenome=HelroG74811|UniProtKB=T1G1W0 T1G1W0 20215058 PTHR20991:SF0 PARATHYROID HORMONE-RESPONSIVE B1 GENE PROTEIN PTHB1 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 protein-containing complex#GO:0032991;BBSome#GO:0034464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG88988|UniProtKB=T1G779 T1G779 20216926 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG162245|UniProtKB=T1ESE4 T1ESE4 20199494 PTHR11685:SF371 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF14 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG159094|UniProtKB=T1ENK9 T1ENK9 20198159 PTHR13022:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG68918|UniProtKB=T1FZL4 T1FZL4 20214262 PTHR24083:SF104 NUCLEAR HORMONE RECEPTOR TRANSCRIPTION FACTOR HNF-4 HOMOLOG transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG160122|UniProtKB=T1EPU1 T1EPU1 20198591 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG180351|UniProtKB=T1FFT0 T1FFT0 20207679 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68553|UniProtKB=T1FZG6 T1FZG6 20214214 PTHR13314:SF2 CALCIUM CHANNEL FLOWER HOMOLOG CALCIUM CHANNEL FLOWER HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 endocytosis#GO:0006897;metal ion transport#GO:0030001;synaptic vesicle endocytosis#GO:0048488;calcium ion transmembrane transport#GO:0070588;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;monoatomic ion transport#GO:0006811;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic vesicle cycle#GO:0099504 membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cell periphery#GO:0071944;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG186181|UniProtKB=T1FNS2 T1FNS2 20210469 PTHR22599:SF1 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB-LIKE PROTEIN PHOCEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG180666|UniProtKB=T1FG52 T1FG52 20207801 PTHR42918:SF18 LYSYL-TRNA SYNTHETASE LYSINE--TRNA LIGASE tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG69922|UniProtKB=T1FZZ7 T1FZZ7 20214395 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG165641|UniProtKB=T1EX41 T1EX41 20201141 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG191868|UniProtKB=T1FTD3 T1FTD3 20212080 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG70587|UniProtKB=T1G089 T1G089 20214487 PTHR12499:SF30 OPTIC ATROPHY 3 PROTEIN OPA3 OPTIC ATROPHY 3 PROTEIN system process#GO:0003008;multicellular organismal process#GO:0032501;nervous system process#GO:0050877;neuromuscular process#GO:0050905 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG188262|UniProtKB=T1FPT4 T1FPT4 20210831 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167613|UniProtKB=T1EZK2 T1EZK2 20202002 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN methyltransferase#PC00155;transferase#PC00220 HELRO|EnsemblGenome=HelroG99297|UniProtKB=T1G9S0 T1G9S0 20217816 PTHR11375:SF0 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG105536|UniProtKB=T1EDW1 T1EDW1 20194763 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158887|UniProtKB=T1END6 T1END6 20198086 PTHR12757:SF1 TUMOR NECROSIS FACTOR INDUCED PROTEIN PROTEIN SALIVARY GLANDS MARRED regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG194592|UniProtKB=T1FW83 T1FW83 20213079 PTHR14247:SF8 BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN SH2 DOMAIN-CONTAINING PROTEIN 3C-RELATED HELRO|EnsemblGenome=HelroG105598|UniProtKB=T1EDW5 T1EDW5 20194767 PTHR12372:SF8 PECANEX PROTEIN PECANEX cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG192396|UniProtKB=T1FTW6 T1FTW6 20212263 PTHR24221:SF664 ATP-BINDING CASSETTE SUB-FAMILY B ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane#GO:0016020;vacuolar membrane#GO:0005774;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG99472|UniProtKB=T1G9S9 T1G9S9 20217825 PTHR13931:SF2 UBIQUITINATION FACTOR E4 UBIQUITIN CONJUGATION FACTOR E4 B catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;response to stimulus#GO:0050896;catabolic process#GO:0009056;response to endoplasmic reticulum stress#GO:0034976;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG65318|UniProtKB=T1FY60 T1FY60 20213758 PTHR12791:SF37 GOLGI SNARE BET1-RELATED BET1-LIKE PROTEIN SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cytosolic transport#GO:0016482;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;localization#GO:0051179;cellular localization#GO:0051641;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;regulation of localization#GO:0032879;regulation of transport#GO:0051049;endosomal transport#GO:0016197;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;membrane#GO:0016020;membrane protein complex#GO:0098796 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG173188|UniProtKB=T1F6I8 T1F6I8 20204437 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171181|UniProtKB=T1F3W7 T1F3W7 20203516 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG114559|UniProtKB=T1EG29 T1EG29 20195531 PTHR11390:SF21 PROKARYOTIC DNA TOPOISOMERASE DNA TOPOISOMERASE 3-ALPHA macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097 cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996 chromosome#GO:0005694;DNA helicase complex#GO:0033202;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG191944|UniProtKB=T1FTF7 T1FTF7 20212104 PTHR13500:SF0 NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1 NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG182310|UniProtKB=T1FI14 T1FI14 20208463 PTHR12048:SF0 CCAAT-BINDING FACTOR-RELATED CCAAT_ENHANCER-BINDING PROTEIN ZETA nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG177025|UniProtKB=T1FB56 T1FB56 20206055 PTHR45989:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA TRANSLATION INITIATION FACTOR EIF2B SUBUNIT GAMMA guanyl-nucleotide exchange factor activity#GO:0005085;translation factor activity#GO:0180051;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;translation initiation factor activity#GO:0003743;molecular function regulator activity#GO:0098772 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;translational initiation#GO:0006413;translation#GO:0006412;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG171080|UniProtKB=T1F3S9 T1F3S9 20203478 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER KARMOISIN, ISOFORM B monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG175017|UniProtKB=T1F8Q6 T1F8Q6 20205205 PTHR11760:SF76 30S/40S RIBOSOMAL PROTEIN S3 SMALL RIBOSOMAL SUBUNIT PROTEIN US3 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;positive regulation of cell communication#GO:0010647;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG110043|UniProtKB=T1EEY6 T1EEY6 20195138 PTHR13274:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S25 SMALL RIBOSOMAL SUBUNIT PROTEIN MS25 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG184608|UniProtKB=T1FLK8 T1FLK8 20209707 PTHR21396:SF2 39S RIBOSOMAL PROTEIN L43 LARGE RIBOSOMAL SUBUNIT PROTEIN ML43 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG172057|UniProtKB=T1F4Z4 T1F4Z4 20203893 PTHR28336:SF1 BA1-643 SIMILAR TO CDNA SEQUENCE BC005537 HELRO|EnsemblGenome=HelroG192241|UniProtKB=T1FTR2 T1FTR2 20212209 PTHR24104:SF51 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184323|UniProtKB=T1FKZ9 T1FKZ9 20209498 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP-TYPE DOMAIN-CONTAINING PROTEIN zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG191881|UniProtKB=T1FTD8 T1FTD8 20212085 PTHR12308:SF74 ANOCTAMIN ANOCTAMIN intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128 transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG156237|UniProtKB=T1ELT1 T1ELT1 20197531 PTHR24410:SF23 HL07962P-RELATED SERINE-ENRICHED PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG176110|UniProtKB=T1FA52 T1FA52 20205701 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174935|UniProtKB=T1F8M7 T1F8M7 20205176 PTHR22198:SF1 FERM DOMAIN-CONTAINING PROTEIN DUF7153 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108618|UniProtKB=T1EEL1 T1EEL1 20195013 PTHR12450:SF22 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN KINASE FAM20C-LIKE ISOFORM X1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;extracellular region#GO:0005576;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72453|UniProtKB=T1G104 T1G104 20214752 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG88074|UniProtKB=T1G6Y1 T1G6Y1 20216828 PTHR24107:SF20 YNEIN REGULATORY COMPLEX SUBUNIT 5 DYNEIN REGULATORY COMPLEX SUBUNIT 5 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG193153|UniProtKB=T1FUN9 T1FUN9 20212535 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG158475|UniProtKB=T1EMU5 T1EMU5 20197895 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG77182|UniProtKB=T1G2U2 T1G2U2 20215390 PTHR12804:SF0 MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23 SIGNAL PEPTIDASE COMPLEX SUBUNIT 3 localization#GO:0051179;protein metabolic process#GO:0019538;protein targeting#GO:0006605;primary metabolic process#GO:0044238;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;protein targeting to ER#GO:0045047;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;establishment of protein localization to endoplasmic reticulum#GO:0072599;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endopeptidase complex#GO:1905369;endoplasmic reticulum membrane#GO:0005789 protease#PC00190 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG81292|UniProtKB=T1G4C7 T1G4C7 20215925 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG66729|UniProtKB=T1FYP7 T1FYP7 20213945 PTHR48013:SF15 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167 Huntington disease#P00029>SEK-1#P00792;Integrin signalling pathway#P00034>MEK#P00925;Apoptosis signaling pathway#P00006>SEK1#P00266;Angiogenesis#P00005>JNKK1#P00199;EGF receptor signaling pathway#P00018>MKK4,7#P00555;FGF signaling pathway#P00021>MKK4,7#P00637;Integrin signalling pathway#P00034>Jnk#P00951;Gonadotropin-releasing hormone receptor pathway#P06664>MKK4/7#P06760;FAS signaling pathway#P00020>MKK4#P00610;Ras Pathway#P04393>MKK4/7#P04565;p38 MAPK pathway#P05918>MKK4#P06034;Toll receptor signaling pathway#P00054>MKK4#P01366;Huntington disease#P00029>MAPKK4#P00787;Oxidative stress response#P00046>MKK4#P01138;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG185121|UniProtKB=T1FMF4 T1FMF4 20210003 PTHR43157:SF74 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED DEHYDROGENASES, SHORT CHAIN-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG194760|UniProtKB=T1FWD8 T1FWD8 20213133 PTHR42861:SF102 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829 cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG160967|UniProtKB=T1EQX7 T1EQX7 20198977 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193618|UniProtKB=T1FV68 T1FV68 20212714 PTHR25462:SF296 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG175784|UniProtKB=T1F9N5 T1F9N5 20205534 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181677|UniProtKB=T1FH81 T1FH81 20208180 PTHR21258:SF62 DOCKING PROTEIN RELATED DOWNSTREAM OF KINASE intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG70349|UniProtKB=T1G053 T1G053 20214451 PTHR16705:SF4 COMPLEXIN COMPLEXIN protein binding#GO:0005515;SNARE binding#GO:0000149;binding#GO:0005488 synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;regulated exocytosis#GO:0045055;vesicle-mediated transport in synapse#GO:0099003;regulation of transport#GO:0051049;exocytosis#GO:0006887;regulation of localization#GO:0032879;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;export from cell#GO:0140352;regulation of signaling#GO:0023051;cellular localization#GO:0051641;secretion by cell#GO:0032940;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903 intracellular anatomical structure#GO:0005622;axon#GO:0030424;synapse#GO:0045202;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;membrane protein complex#GO:0098796;cell junction#GO:0030054;axon terminus#GO:0043679;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;neuron projection#GO:0043005;presynapse#GO:0098793 HELRO|EnsemblGenome=HelroG180916|UniProtKB=T1FGE8 T1FGE8 20207897 PTHR35683:SF4 YALI0C04136P YALI0C04136P HELRO|EnsemblGenome=HelroG114251|UniProtKB=T1EG04 T1EG04 20195506 PTHR11363:SF5 60S RIBOSOMAL PROTEIN L3-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL3 structural molecule activity#GO:0005198;RNA binding#GO:0003723;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488 biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG77670|UniProtKB=T1G319 T1G319 20215467 PTHR12788:SF10 PROTEIN-TYROSINE SULFOTRANSFERASE 2 PROTEIN-TYROSINE SULFOTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220 HELRO|EnsemblGenome=HelroG188672|UniProtKB=T1FQ84 T1FQ84 20210981 PTHR10826:SF1 COMPLEMENT COMPONENT 1 COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517 macromolecule metabolic process#GO:0043170;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;RNA catabolic process#GO:0006401;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG153393|UniProtKB=T1EL67 T1EL67 20197317 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG168778|UniProtKB=T1F0Y4 T1F0Y4 20202484 PTHR24403:SF48 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 10 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168363|UniProtKB=T1F0H2 T1F0H2 20202322 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG177632|UniProtKB=T1FBZ0 T1FBZ0 20206339 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194028|UniProtKB=T1FVL1 T1FVL1 20212857 PTHR24112:SF69 LEUCINE-RICH REPEAT, ISOFORM F-RELATED LEUCINE-RICH REPEAT, ISOFORM F biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin nucleation#GO:0051125;regulation of actin filament-based process#GO:0032970 cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG192583|UniProtKB=T1FU36 T1FU36 20212332 PTHR23184:SF9 TETRATRICOPEPTIDE REPEAT PROTEIN 14 TETRATRICOPEPTIDE REPEAT PROTEIN 14 HELRO|EnsemblGenome=HelroG194240|UniProtKB=T1FVU7 T1FVU7 20212943 PTHR14728:SF2 PROTEIN AURORA BOREALIS PROTEIN AURORA BOREALIS protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346;regulation of organelle organization#GO:0033043;regulation of spindle organization#GO:0090224;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;regulation of nuclear division#GO:0051783;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of microtubule-based process#GO:0032886;regulation of mitotic spindle organization#GO:0060236;regulation of mitotic nuclear division#GO:0007088 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG87388|UniProtKB=T1G6P5 T1G6P5 20216742 PTHR11743:SF70 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL GH26960P-RELATED gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;voltage-gated monoatomic anion channel activity#GO:0008308;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;intracellular transport#GO:0046907;cellular localization#GO:0051641;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mitochondrial transport#GO:0006839 organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG152392|UniProtKB=T1EKR2 T1EKR2 20197162 PTHR46289:SF20 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG172918|UniProtKB=T1F647 T1F647 20204296 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84665|UniProtKB=T1G5L5 T1G5L5 20216362 PTHR46809:SF2 STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN GH21273P HELRO|EnsemblGenome=HelroG183836|UniProtKB=T1FK91 T1FK91 20209240 PTHR13628:SF1 TRANSMEMBRANE PROTEIN 267 TRANSMEMBRANE PROTEIN 267 HELRO|EnsemblGenome=HelroG97580|UniProtKB=T1G9H7 T1G9H7 20217724 PTHR13720:SF50 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG112321|UniProtKB=T1EFI6 T1EFI6 20195338 PTHR19376:SF11 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1 gene expression#GO:0010467;nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription by RNA polymerase I#GO:0006360;rRNA transcription#GO:0009303;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171977|UniProtKB=T1F4W8 T1F4W8 20203867 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193623|UniProtKB=T1FV70 T1FV70 20212716 PTHR12953:SF0 MEMBRANE PROTEIN CH1 RELATED LD18032P cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 structural protein#PC00211 HELRO|EnsemblGenome=HelroG79231|UniProtKB=T1G3L6 T1G3L6 20215664 PTHR45810:SF18 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG95981|UniProtKB=T1G996 T1G996 20217643 PTHR22792:SF140 LUPUS LA PROTEIN-RELATED ACHILLES, ISOFORM A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161665|UniProtKB=T1ERR6 T1ERR6 20199266 PTHR14386:SF2 PROTEIN FAM204A PROTEIN FAM204A HELRO|EnsemblGenome=HelroG191555|UniProtKB=T1FT28 T1FT28 20211975 PTHR12027:SF102 WNT RELATED PROTEIN WNT molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488 response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HELRO|EnsemblGenome=HelroG191330|UniProtKB=T1FSW3 T1FSW3 20211910 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62740|UniProtKB=T1FX44 T1FX44 20213392 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG190006|UniProtKB=T1FRL0 T1FRL0 20211457 PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG94361|UniProtKB=T1G905 T1G905 20217552 PTHR11630:SF46 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM3-RELATED DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;MCM complex#GO:0042555;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG162439|UniProtKB=T1ESN3 T1ESN3 20199583 PTHR15592:SF14 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG153314|UniProtKB=T1EL33 T1EL33 20197283 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126271|UniProtKB=T1EH90 T1EH90 20195940 PTHR23235:SF182 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG96459|UniProtKB=T1G9C2 T1G9C2 20217669 PTHR23049:SF79 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN, LIGHT CHAIN 12, GENOME DUPLICATE 1-RELATED myosin binding#GO:0017022;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG106819|UniProtKB=T1EE52 T1EE52 20194854 PTHR11814:SF282 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HELRO|EnsemblGenome=HelroG180278|UniProtKB=T1FFN9 T1FFN9 20207638 PTHR46467:SF1 TETHER CONTAINING UBX DOMAIN FOR GLUT4 TETHER CONTAINING UBX DOMAIN FOR GLUT4 carbohydrate homeostasis#GO:0033500;homeostatic process#GO:0042592;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;glucose homeostasis#GO:0042593;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234 nucleus#GO:0005634;vesicle#GO:0031982;membrane#GO:0016020;vesicle membrane#GO:0012506;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG193196|UniProtKB=T1FUQ7 T1FUQ7 20212553 PTHR44163:SF1 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of DNA-templated transcription#GO:0006355;rRNA processing#GO:0006364;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;rRNA metabolic process#GO:0016072;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274 intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;t-UTP complex#GO:0034455;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG186484|UniProtKB=T1FP00 T1FP00 20210547 PTHR10766:SF176 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;localization within membrane#GO:0051668 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG172907|UniProtKB=T1F641 T1F641 20204290 PTHR11905:SF263 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 protease#PC00190;metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG183126|UniProtKB=T1FJ61 T1FJ61 20208860 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell migration#GO:0016477;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG185081|UniProtKB=T1FMD4 T1FMD4 20209983 PTHR12277:SF204 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PALMITOYL-PROTEIN HYDROLASE palmitoyl hydrolase activity#GO:0098599;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 serine protease#PC00203 HELRO|EnsemblGenome=HelroG189893|UniProtKB=T1FRG5 T1FRG5 20211412 PTHR11616:SF338 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370 monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;glycine transport#GO:0015816;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;import into cell#GO:0098657;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG186957|UniProtKB=T1FP48 T1FP48 20210595 PTHR11627:SF80 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE lyase activity#GO:0016829;aldehyde-lyase activity#GO:0016832;fructose-bisphosphate aldolase activity#GO:0004332;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;ADP catabolic process#GO:0046032;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 lyase#PC00144;aldolase#PC00044 Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959;Glycolysis#P00024>Aldolase#P00679 HELRO|EnsemblGenome=HelroG160226|UniProtKB=T1EPZ9 T1EPZ9 20198649 PTHR32343:SF84 SERINE/ARGININE-RICH SPLICING FACTOR LD29830P RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG194643|UniProtKB=T1FW98 T1FW98 20213094 PTHR21428:SF11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of DNA-templated transcription initiation#GO:2000142;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG173631|UniProtKB=T1F726 T1F726 20204625 PTHR48071:SF37 SRCR DOMAIN-CONTAINING PROTEIN SRCR DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183352|UniProtKB=T1FJI0 T1FJI0 20208979 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181659|UniProtKB=T1FH76 T1FH76 20208175 PTHR24229:SF114 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;peptide binding#GO:0042277;neuropeptide binding#GO:0042923 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG180074|UniProtKB=T1FFG1 T1FFG1 20207560 PTHR19325:SF577 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G defense/immunity protein#PC00090;complement component#PC00078 HELRO|EnsemblGenome=HelroG169950|UniProtKB=T1F2H0 T1F2H0 20203020 PTHR13551:SF1 BRAIN PROTEIN I3 MEMBRANE PROTEIN BRI3 HELRO|EnsemblGenome=HelroG123324|UniProtKB=T1EGX5 T1EGX5 20195825 PTHR23227:SF89 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183221|UniProtKB=T1FJC1 T1FJC1 20208920 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG78113|UniProtKB=T1G381 T1G381 20215529 PTHR24068:SF41 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-24 KDA ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG112750|UniProtKB=T1EFL9 T1EFL9 20195371 PTHR22767:SF18 N-TERMINAL ACETYLTRANSFERASE-RELATED N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 acetyltransferase complex#GO:1902493;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG89573|UniProtKB=T1G7E4 T1G7E4 20216991 PTHR48012:SF18 STERILE20-LIKE KINASE, ISOFORM B-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>GCKR#P00311;Apoptosis signaling pathway#P00006>GCK#P00268 HELRO|EnsemblGenome=HelroG174911|UniProtKB=T1F8L8 T1F8L8 20205167 PTHR46173:SF1 CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;tRNA binding#GO:0000049 RNA 3'-end processing#GO:0031123;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mitochondrial RNA 3'-end processing#GO:0000965;tRNA 3'-end processing#GO:0042780;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG92373|UniProtKB=T1G8F3 T1G8F3 20217350 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 mRNA capping factor#PC00145;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG177209|UniProtKB=T1FBC8 T1FBC8 20206127 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG185960|UniProtKB=T1FNH7 T1FNH7 20210374 PTHR24250:SF50 CHYMOTRYPSIN-RELATED EPITHELIAL SERINE PROTEASE catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG80430|UniProtKB=T1G406 T1G406 20215804 PTHR13460:SF0 FAMILY NOT NAMED MALECTIN binding#GO:0005488;carbohydrate binding#GO:0030246 primary metabolic process#GO:0044238;cellular process#GO:0009987;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG190040|UniProtKB=T1FRM2 T1FRM2 20211469 PTHR47958:SF24 ATP-DEPENDENT RNA HELICASE DBP3 NUCLEOLAR RNA HELICASE 2-RELATED ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG91526|UniProtKB=T1G849 T1G849 20217246 PTHR31655:SF7 PROTEIN FAM78A PROTEIN FAM78B-LIKE HELRO|EnsemblGenome=HelroG189299|UniProtKB=T1FQX7 T1FQX7 20211224 PTHR12553:SF49 ZINC PHOSPHODIESTERASE ELAC PROTEIN 2 ZINC PHOSPHODIESTERASE ELAC PROTEIN 2 catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;nuclease activity#GO:0004518 nucleic acid biosynthetic process#GO:0141187;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;tRNA 3'-end processing#GO:0042780;mitochondrial RNA 3'-end processing#GO:0000965 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG111519|UniProtKB=T1EFC0 T1EFC0 20195272 PTHR12001:SF55 GERANYLGERANYL PYROPHOSPHATE SYNTHASE ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 isoprenoid biosynthetic process#GO:0008299;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;isoprenoid metabolic process#GO:0006720;ubiquinone biosynthetic process#GO:0006744;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ketone metabolic process#GO:0042180;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169918|UniProtKB=T1F2G1 T1F2G1 20203011 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG175643|UniProtKB=T1F9G6 T1F9G6 20205465 PTHR45695:SF9 LEUCOKININ RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG86631|UniProtKB=T1G6E6 T1G6E6 20216643 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;trans-synaptic signaling#GO:0099537 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG169572|UniProtKB=T1F242 T1F242 20202892 PTHR19134:SF495 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE 69D phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell development#GO:0048468;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183157|UniProtKB=T1FJ83 T1FJ83 20208882 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92354|UniProtKB=T1G8E9 T1G8E9 20217346 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG169924|UniProtKB=T1F2G3 T1F2G3 20203013 PTHR44324:SF4 WD40 REPEAT DOMAIN 95 WD40 REPEAT DOMAIN 95 HELRO|EnsemblGenome=HelroG169289|UniProtKB=T1F1Q7 T1F1Q7 20202757 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190449|UniProtKB=T1FS02 T1FS02 20211599 PTHR10742:SF410 FLAVIN MONOAMINE OXIDASE LYSINE-SPECIFIC HISTONE DEMETHYLASE 2 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidase#PC00175 HELRO|EnsemblGenome=HelroG175155|UniProtKB=T1F8X5 T1F8X5 20205274 PTHR46630:SF3 TETRATRICOPEPTIDE REPEAT PROTEIN 29 TETRATRICOPEPTIDE REPEAT PROTEIN 29 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cilium movement#GO:0003341;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG66727|UniProtKB=T1FYP5 T1FYP5 20213943 PTHR11933:SF10 TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783 mitochondrial RNA modification#GO:1900864;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mitochondrial RNA metabolic process#GO:0000959;tRNA thio-modification#GO:0034227;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;mitochondrial gene expression#GO:0140053;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble position uridine thiolation#GO:0002143;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG189319|UniProtKB=T1FQY2 T1FQY2 20211229 PTHR45625:SF6 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG catalytic activity, acting on a protein#GO:0140096;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859;catalytic activity#GO:0003824 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 chaperone#PC00072 HELRO|EnsemblGenome=HelroG189030|UniProtKB=T1FQK8 T1FQK8 20211105 PTHR24356:SF414 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 signaling#GO:0023052;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of mitotic cell cycle#GO:0007346;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG96179|UniProtKB=T1G9A5 T1G9A5 20217652 PTHR24031:SF790 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA helicase#PC00032;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188708|UniProtKB=T1FQA2 T1FQA2 20210999 PTHR14493:SF87 UNKEMPT FAMILY MEMBER RING FINGER PROTEIN UNKEMPT HELRO|EnsemblGenome=HelroG106596|UniProtKB=T1EE36 T1EE36 20194838 PTHR10953:SF6 UBIQUITIN-ACTIVATING ENZYME E1 NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG169462|UniProtKB=T1F1Z0 T1F1Z0 20202840 PTHR15827:SF2 CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Cell cycle#P00013>Cdk2#P00485 HELRO|EnsemblGenome=HelroG98035|UniProtKB=T1G9K2 T1G9K2 20217748 PTHR10890:SF33 CYSTEINYL-TRNA SYNTHETASE CYSTEINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG187944|UniProtKB=T1FPH7 T1FPH7 20210724 PTHR13140:SF713 MYOSIN UNCONVENTIONAL MYOSIN ID macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 actin filament-based process#GO:0030029;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based movement#GO:0030048;endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;microvillus#GO:0005902;actin-based cell projection#GO:0098858;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG185519|UniProtKB=T1FMX3 T1FMX3 20210172 PTHR12704:SF2 TRANS-GOLGI PROTEIN GMX33 GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON HELRO|EnsemblGenome=HelroG141144|UniProtKB=T1EJ27 T1EJ27 20196577 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;response to chemical#GO:0042221;response to stimulus#GO:0050896;lipid metabolic process#GO:0006629;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG150433|UniProtKB=T1EKF7 T1EKF7 20197057 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;protein binding#GO:0005515 chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG194693|UniProtKB=T1FWB8 T1FWB8 20213114 PTHR35970:SF1 SODIUM CHANNEL AND CLATHRIN LINKER 1 SODIUM CHANNEL AND CLATHRIN LINKER 1 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190041|UniProtKB=T1FRM3 T1FRM3 20211470 PTHR13155:SF1 A-KINASE ANCHOR PROTEINS A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186116|UniProtKB=T1FNP1 T1FNP1 20210438 PTHR33444:SF2 SI:DKEY-19B23.12-RELATED TRANSMEMBRANE PROTEIN 272-RELATED HELRO|EnsemblGenome=HelroG165792|UniProtKB=T1EXA4 T1EXA4 20201204 PTHR11614:SF198 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;membrane#GO:0016020 lipase#PC00143;phospholipase#PC00186 HELRO|EnsemblGenome=HelroG98251|UniProtKB=T1G9L4 T1G9L4 20217760 PTHR11893:SF36 INNEXIN INNEXIN gap junction#PC00105 HELRO|EnsemblGenome=HelroG182204|UniProtKB=T1FHX4 T1FHX4 20208423 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76315|UniProtKB=T1G2I2 T1G2I2 20215280 PTHR18952:SF283 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XB-RELATED dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169045|UniProtKB=T1F1B2 T1F1B2 20202612 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105912|UniProtKB=T1EDY6 T1EDY6 20194788 PTHR10901:SF6 TROPOMODULIN TROPOMODULIN, ISOFORM N cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cellular developmental process#GO:0048869;system process#GO:0003008;actin filament organization#GO:0007015;developmental process#GO:0032502;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692 membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;contractile muscle fiber#GO:0043292 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG71774|UniProtKB=T1G0R5 T1G0R5 20214663 PTHR24083:SF189 NUCLEAR HORMONE RECEPTOR PROTEIN TAILLESS transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG174497|UniProtKB=T1F870 T1F870 20205019 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG112347|UniProtKB=T1EFJ0 T1EFJ0 20195342 PTHR10288:SF339 KH DOMAIN CONTAINING RNA BINDING PROTEIN RNA-BINDING PROTEIN PASILLA RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions#GO:0000375;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169602|UniProtKB=T1F256 T1F256 20202906 PTHR22760:SF3 GLYCOSYLTRANSFERASE GPI ALPHA-1,2-MANNOSYLTRANSFERASE 4 glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 organophosphate metabolic process#GO:0019637;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;carbohydrate derivative metabolic process#GO:1901135;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;glycolipid biosynthetic process#GO:0009247 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG192399|UniProtKB=T1FTW8 T1FTW8 20212265 PTHR46766:SF1 GLUTAMINE-RICH PROTEIN 2 GLUTAMINE RICH 2 HELRO|EnsemblGenome=HelroG173535|UniProtKB=T1F6Y5 T1F6Y5 20204584 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG188988|UniProtKB=T1FQJ2 T1FQJ2 20211089 PTHR46186:SF2 CYSTATIN CYSTATIN-RELATED peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 vesicle#GO:0031982;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG94228|UniProtKB=T1G8Z5 T1G8Z5 20217542 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MULTIDRUG RESISTANCE PROTEIN HOMOLOG 49-RELATED transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 ATP-binding cassette (ABC) transporter#PC00003 HELRO|EnsemblGenome=HelroG140970|UniProtKB=T1EJ22 T1EJ22 20196572 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HELRO|EnsemblGenome=HelroG175268|UniProtKB=T1F928 T1F928 20205327 PTHR21580:SF28 SHIPPO-1-RELATED SPERM-TAIL PG-RICH REPEAT FAMILY PROTEIN intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 structural protein#PC00211 HELRO|EnsemblGenome=HelroG191571|UniProtKB=T1FT33 T1FT33 20211980 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG189063|UniProtKB=T1FQL9 T1FQL9 20211116 PTHR11616:SF340 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;glycine transmembrane transporter activity#GO:0015187;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;nitrogen compound transport#GO:0071705;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;glycine transport#GO:0015816;monoatomic ion transport#GO:0006811;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;monoatomic cation transport#GO:0006812;localization#GO:0051179;sodium ion transport#GO:0006814;carboxylic acid transmembrane transport#GO:1905039;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG120472|UniProtKB=T1EGQ0 T1EGQ0 20195750 PTHR24028:SF146 CADHERIN-87A CADHERIN-87A cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HELRO|EnsemblGenome=HelroG166444|UniProtKB=T1EY52 T1EY52 20201502 PTHR23036:SF195 CYTOKINE RECEPTOR CYTOKINE RECEPTOR-LIKE FACTOR 3 cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG154543|UniProtKB=T1ELF0 T1ELF0 20197400 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cellular localization#GO:0051641;establishment of organelle localization#GO:0051656;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;localization#GO:0051179;organelle localization#GO:0051640;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;nucleus organization#GO:0006997;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;protein localization to nucleus#GO:0034504;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule localization#GO:0033036;negative regulation of macromolecule metabolic process#GO:0010605 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear lumen#GO:0031981;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG170422|UniProtKB=T1F313 T1F313 20203212 PTHR47633:SF4 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158934|UniProtKB=T1ENF3 T1ENF3 20198103 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG174269|UniProtKB=T1F7X0 T1F7X0 20204919 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG184146|UniProtKB=T1FKN7 T1FKN7 20209386 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG75405|UniProtKB=T1G247 T1G247 20215145 PTHR43078:SF54 UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED UDP-GLUCURONIC ACID DECARBOXYLASE 1 carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;lyase activity#GO:0016829 small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-sugar metabolic process#GO:0009225;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 lyase#PC00144;decarboxylase#PC00089 HELRO|EnsemblGenome=HelroG171017|UniProtKB=T1F3P8 T1F3P8 20203447 PTHR19282:SF519 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179618|UniProtKB=T1FEY0 T1FEY0 20207379 PTHR46218:SF4 LASP LIM AND SH3 DOMAIN PROTEIN LASP protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 anchoring junction#GO:0070161;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HELRO|EnsemblGenome=HelroG182705|UniProtKB=T1FIM0 T1FIM0 20208669 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163142|UniProtKB=T1ETQ0 T1ETQ0 20199950 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176222|UniProtKB=T1FAB3 T1FAB3 20205762 PTHR12990:SF5 ARMET-LIKE PROTEIN MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cellular component organization#GO:0016043;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG185530|UniProtKB=T1FMX8 T1FMX8 20210177 PTHR10352:SF88 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG64663|UniProtKB=T1FXX6 T1FXX6 20213674 PTHR12469:SF2 PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;electron transport chain#GO:0022900;tricarboxylic acid cycle#GO:0006099;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex II assembly#GO:0034553;mitochondrion organization#GO:0007005;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;cellular component organization or biogenesis#GO:0071840;energy derivation by oxidation of organic compounds#GO:0015980;protein-containing complex organization#GO:0043933 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189969|UniProtKB=T1FRJ6 T1FRJ6 20211443 PTHR10279:SF10 ORNITHINE DECARBOXYLASE ANTIZYME ORNITHINE DECARBOXYLASE ANTIZYME enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG110490|UniProtKB=T1EF28 T1EF28 20195180 PTHR23406:SF96 MALIC ENZYME-RELATED MALIC ENZYME oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG62268|UniProtKB=T1FWY1 T1FWY1 20213329 PTHR23359:SF70 NUCLEOTIDE KINASE ADENYLATE KINASE ISOENZYME 1 phosphotransferase activity, phosphate group as acceptor#GO:0016776;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG67009|UniProtKB=T1FYV1 T1FYV1 20213999 PTHR15860:SF0 UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN LP20373P acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 HELRO|EnsemblGenome=HelroG77175|UniProtKB=T1G2U0 T1G2U0 20215388 PTHR12281:SF32 RP42 RELATED DCN1-LIKE PROTEIN 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515 regulation of protein modification process#GO:0031399;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG163856|UniProtKB=T1EUJ6 T1EUJ6 20200246 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;binding#GO:0005488;hormone binding#GO:0042562 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG134157|UniProtKB=T1EI34 T1EI34 20196234 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;adenosine deaminase activity#GO:0004000;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 nucleoside catabolic process#GO:0009164;purine nucleoside metabolic process#GO:0042278;purine-containing compound biosynthetic process#GO:0072522;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside metabolic process#GO:0009116;purine-containing compound metabolic process#GO:0072521;nucleobase-containing small molecule catabolic process#GO:0034656;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside catabolic process#GO:0006152;nucleobase metabolic process#GO:0009112;purine-containing compound catabolic process#GO:0072523;carbohydrate derivative biosynthetic process#GO:1901137;small molecule biosynthetic process#GO:0044283;purine nucleobase metabolic process#GO:0006144;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;adenosine metabolic process#GO:0046085;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound catabolic process#GO:1901658 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cytosol#GO:0005829 deaminase#PC00088 HELRO|EnsemblGenome=HelroG186384|UniProtKB=T1FNZ0 T1FNZ0 20210537 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183202|UniProtKB=T1FJA7 T1FJA7 20208906 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 HELRO|EnsemblGenome=HelroG167639|UniProtKB=T1EZL4 T1EZL4 20202014 PTHR10684:SF4 NUCLEAR RECEPTOR COACTIVATOR TAIMAN, ISOFORM G DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription regulator activity#GO:0140110;binding#GO:0005488;transcription coactivator activity#GO:0003713;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712 cellular response to chemical stimulus#GO:0070887;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG165876|UniProtKB=T1EXE1 T1EXE1 20201241 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72374|UniProtKB=T1G0Z0 T1G0Z0 20214738 PTHR46392:SF1 DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE positive regulation of cellular process#GO:0048522;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;negative regulation of cellular process#GO:0048523;positive regulation of MAPK cascade#GO:0043410;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;cellular response to fibroblast growth factor stimulus#GO:0044344;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG178025|UniProtKB=T1FCM4 T1FCM4 20206573 PTHR45692:SF1 G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180745|UniProtKB=T1FG83 T1FG83 20207832 PTHR12186:SF2 SIKE FAMILY MEMBER FGFR1 ONCOGENE PARTNER 2 HOMOLOG HELRO|EnsemblGenome=HelroG148455|UniProtKB=T1EK87 T1EK87 20196987 PTHR28596:SF1 BBSOME-INTERACTING PROTEIN 1 BBSOME-INTERACTING PROTEIN 1 cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512;organelle assembly#GO:0070925;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;cilium organization#GO:0044782;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;protein localization to cell periphery#GO:1990778;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;BBSome#GO:0034464;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;ciliary membrane#GO:0060170;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG191938|UniProtKB=T1FTF3 T1FTF3 20212100 PTHR12756:SF12 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5 binding#GO:0005488;metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;protein binding#GO:0005515;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG62184|UniProtKB=T1FWW7 T1FWW7 20213315 PTHR11134:SF34 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-3 COMPLEX SUBUNIT BETA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 Golgi vesicle transport#GO:0048193;lytic vacuole organization#GO:0080171;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;lysosome organization#GO:0007040;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle-mediated transport#GO:0016192;vacuole organization#GO:0007033;post-Golgi vesicle-mediated transport#GO:0006892;Golgi to vacuole transport#GO:0006896;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043 membrane#GO:0016020;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;AP-type membrane coat adaptor complex#GO:0030119 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG70559|UniProtKB=T1G085 T1G085 20214483 PTHR12262:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9 regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;CCR4-NOT complex#GO:0030014;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG62964|UniProtKB=T1FX87 T1FX87 20213435 PTHR16160:SF13 FERMITIN 2-RELATED FERMITIN 2-RELATED protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cell-substrate adhesion#GO:0031589;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;cell-substrate junction#GO:0030055 HELRO|EnsemblGenome=HelroG193262|UniProtKB=T1FUT2 T1FUT2 20212578 PTHR10091:SF0 ALDOSE-1-EPIMERASE GALACTOSE MUTAROTASE isomerase activity#GO:0016853;racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857 carbohydrate catabolic process#GO:0016052;glucose metabolic process#GO:0006006;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;organophosphate metabolic process#GO:0019637;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 epimerase/racemase#PC00096 HELRO|EnsemblGenome=HelroG158399|UniProtKB=T1EMR4 T1EMR4 20197864 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77646|UniProtKB=T1G315 T1G315 20215463 PTHR11361:SF21 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER MUTS PROTEIN HOMOLOG 4 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;reproductive process#GO:0022414;homologous recombination#GO:0035825;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;organelle fission#GO:0048285;organelle organization#GO:0006996;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG156728|UniProtKB=T1EM04 T1EM04 20197604 PTHR11805:SF2 CYSTEINE-RICH PDZ-BINDING PROTEIN CYSTEINE-RICH PDZ-BINDING PROTEIN cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447;neuron projection#GO:0043005 HELRO|EnsemblGenome=HelroG80617|UniProtKB=T1G429 T1G429 20215827 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG153318|UniProtKB=T1EL36 T1EL36 20197286 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162133|UniProtKB=T1ES98 T1ES98 20199448 PTHR23167:SF46 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;actin filament-based process#GO:0030029;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65637|UniProtKB=T1FYB0 T1FYB0 20213808 PTHR19960:SF25 TEKTIN TEKTIN-1 microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG189127|UniProtKB=T1FQP6 T1FQP6 20211143 PTHR11101:SF97 PHOSPHATE TRANSPORTER PHOSPHATE TRANSPORTER sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;phosphate transmembrane transporter activity#GO:0005315 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG83430|UniProtKB=T1G554 T1G554 20216202 PTHR16134:SF18 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 17 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;catabolic process#GO:0009056;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;response to external stimulus#GO:0009605;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;photoperiodism#GO:0009648;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;cellular process#GO:0009987;response to radiation#GO:0009314;regulation of circadian rhythm#GO:0042752 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG183384|UniProtKB=T1FJJ6 T1FJJ6 20208995 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190660|UniProtKB=T1FS66 T1FS66 20211663 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG64698|UniProtKB=T1FXY1 T1FXY1 20213679 PTHR23048:SF33 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN ALKALI myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;contractile muscle fiber#GO:0043292;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG107973|UniProtKB=T1EEE5 T1EEE5 20194947 PTHR44086:SF15 THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220 HELRO|EnsemblGenome=HelroG188448|UniProtKB=T1FPZ9 T1FPZ9 20210896 PTHR19321:SF57 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;nuclear division#GO:0000280;organelle assembly#GO:0070925;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG171077|UniProtKB=T1F3S7 T1F3S7 20203476 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER KARMOISIN, ISOFORM B carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG169862|UniProtKB=T1F2D9 T1F2D9 20202989 PTHR31395:SF26 SHISA GEO05642P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG165501|UniProtKB=T1EWX3 T1EWX3 20201073 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG106328|UniProtKB=T1EE20 T1EE20 20194822 PTHR14963:SF1 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of signal transduction#GO:0009966;regulation of actin filament polymerization#GO:0030833;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;regulation of response to stimulus#GO:0048583;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure size#GO:0090066;regulation of cell communication#GO:0010646;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;regulation of signaling#GO:0023051;regulation of actin filament length#GO:0030832;regulation of intracellular signal transduction#GO:1902531 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG142036|UniProtKB=T1EJ47 T1EJ47 20196597 PTHR24230:SF166 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG184215|UniProtKB=T1FKS3 T1FKS3 20209422 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN CC8K15.2-LIKE PROTEIN HELRO|EnsemblGenome=HelroG75439|UniProtKB=T1G251 T1G251 20215149 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;catalytic activity#GO:0003824;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG65566|UniProtKB=T1FY99 T1FY99 20213797 PTHR22891:SF111 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-3 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG149307|UniProtKB=T1EKC6 T1EKC6 20197026 PTHR45992:SF12 EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED EUKARYOTIC ELONGATION FACTOR 2 KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 cell junction#GO:0030054;postsynaptic density#GO:0014069;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572;postsynapse#GO:0098794 Oxidative stress response#P00046>eEF2K#P01127;p38 MAPK pathway#P05918>eEF2K#P06022 HELRO|EnsemblGenome=HelroG91172|UniProtKB=T1G807 T1G807 20217204 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71575|UniProtKB=T1G0N7 T1G0N7 20214635 PTHR23048:SF60 MYOSIN LIGHT CHAIN 1, 3 CA2+ BINDING PROTEIN intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG193244|UniProtKB=T1FUS5 T1FUS5 20212571 PTHR21494:SF3 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 HELRO|EnsemblGenome=HelroG160116|UniProtKB=T1EPT8 T1EPT8 20198588 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65456|UniProtKB=T1FY79 T1FY79 20213777 PTHR12223:SF45 VESICULAR MANNOSE-BINDING LECTIN RE50040P monosaccharide binding#GO:0048029;carbohydrate binding#GO:0030246;small molecule binding#GO:0036094;binding#GO:0005488 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170544|UniProtKB=T1F364 T1F364 20203263 PTHR47695:SF3 PID DOMAIN-CONTAINING PROTEIN NUCLEAR PORE COMPLEX PROTEIN DDB_G0274915-LIKE ISOFORM X1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG170304|UniProtKB=T1F2W6 T1F2W6 20203165 PTHR44324:SF6 WD40 REPEAT DOMAIN 95 WD REPEAT-CONTAINING PROTEIN ON Y CHROMOSOME HELRO|EnsemblGenome=HelroG157857|UniProtKB=T1EMG9 T1EMG9 20197769 PTHR13183:SF4 AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28 AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1 protein binding#GO:0005515;binding#GO:0005488 ciliary base#GO:0097546;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG183623|UniProtKB=T1FJY3 T1FJY3 20209132 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG85110|UniProtKB=T1G5S9 T1G5S9 20216426 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG161459|UniProtKB=T1ERH7 T1ERH7 20199177 PTHR11731:SF200 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED VENOM DIPEPTIDYL PEPTIDASE 4 peptidase activity#GO:0008233;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG191231|UniProtKB=T1FSR6 T1FSR6 20211863 PTHR24006:SF943 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE PUF catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG180354|UniProtKB=T1FFT2 T1FFT2 20207681 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188563|UniProtKB=T1FQ46 T1FQ46 20210943 PTHR39490:SF8 ARRESTIN DOMAIN-CONTAINING PROTEIN D ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 HELRO|EnsemblGenome=HelroG161238|UniProtKB=T1ER88 T1ER88 20199088 PTHR37162:SF15 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153940|UniProtKB=T1ELD2 T1ELD2 20197382 PTHR16705:SF4 COMPLEXIN COMPLEXIN binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;secretion by cell#GO:0032940;cellular localization#GO:0051641;regulation of signaling#GO:0023051;export from cell#GO:0140352;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;exocytosis#GO:0006887;regulation of localization#GO:0032879;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536 membrane#GO:0016020;neuron projection#GO:0043005;presynapse#GO:0098793;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cell junction#GO:0030054;axon terminus#GO:0043679;membrane protein complex#GO:0098796;SNARE complex#GO:0031201;synapse#GO:0045202;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection terminus#GO:0044306;axon#GO:0030424;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76349|UniProtKB=T1G2I7 T1G2I7 20215285 PTHR42753:SF10 MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER PROLINE--TRNA LIGASE, MITOCHONDRIAL-RELATED catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG103632|UniProtKB=T1EDG7 T1EDG7 20194619 PTHR43814:SF1 ARGININOSUCCINATE LYASE ARGININOSUCCINATE LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 L-arginine biosynthetic process#GO:0006526;proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 lyase#PC00144 Arginine biosynthesis#P02728>argininosuccinate lyase#P02841 HELRO|EnsemblGenome=HelroG181069|UniProtKB=T1FGK7 T1FGK7 20207956 PTHR24023:SF1140 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG110458|UniProtKB=T1EF23 T1EF23 20195175 PTHR11668:SF530 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Y-RELATED catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG115799|UniProtKB=T1EGA6 T1EGA6 20195608 PTHR19981:SF1 TALIN RHEA, ISOFORM B integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cell adhesion#GO:0007155;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 Integrin signalling pathway#P00034>Talin#P00943 HELRO|EnsemblGenome=HelroG64786|UniProtKB=T1FXZ3 T1FXZ3 20213691 PTHR13068:SF112 CGI-12 PROTEIN-RELATED TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;mitochondrial ribosome assembly#GO:0061668;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;organelle assembly#GO:0070925;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component assembly#GO:0022607;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;negative regulation of metabolic process#GO:0009892;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of biological process#GO:0048519;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HELRO|EnsemblGenome=HelroG174654|UniProtKB=T1F8C7 T1F8C7 20205076 PTHR10288:SF358 KH DOMAIN CONTAINING RNA BINDING PROTEIN P-ELEMENT SOMATIC INHIBITOR, ISOFORM C nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of mRNA splicing, via spliceosome#GO:0048024;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162562|UniProtKB=T1ESU3 T1ESU3 20199643 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN N-acetyltransferase activity#GO:0008080;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212 HELRO|EnsemblGenome=HelroG174675|UniProtKB=T1F8D0 T1F8D0 20205079 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG163169|UniProtKB=T1ETR2 T1ETR2 20199962 PTHR42753:SF9 MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN ML39 ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG177605|UniProtKB=T1FBX6 T1FBX6 20206325 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG182591|UniProtKB=T1FIF4 T1FIF4 20208603 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG183923|UniProtKB=T1FKA9 T1FKA9 20209258 PTHR11034:SF40 N-MYC DOWNSTREAM REGULATED BCDNA.GH02439 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 serine protease#PC00203 HELRO|EnsemblGenome=HelroG89689|UniProtKB=T1G7F9 T1G7F9 20217006 PTHR11267:SF204 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR 3B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell fate specification#GO:0001708;developmental process#GO:0032502 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HELRO|EnsemblGenome=HelroG194626|UniProtKB=T1FW89 T1FW89 20213085 PTHR12271:SF140 POLY A POLYMERASE CID PAP -RELATED POLY(A) RNA POLYMERASE GLD2 catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA processing#GO:0006396;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA processing#GO:0006397;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;RNA 3'-end processing#GO:0031123;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG190366|UniProtKB=T1FRX6 T1FRX6 20211573 PTHR34491:SF156 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED AUGMIN COMPLEX SUBUNIT DGT5 HELRO|EnsemblGenome=HelroG194251|UniProtKB=T1FVV1 T1FVV1 20212947 PTHR23202:SF131 WASP INTERACTING PROTEIN-RELATED LETHAL (3) PERSISTENT SALIVARY GLAND 2 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG179517|UniProtKB=T1FEU0 T1FEU0 20207339 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163408|UniProtKB=T1EU04 T1EU04 20200054 PTHR31684:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 43 COILED-COIL DOMAIN-CONTAINING PROTEIN 43 HELRO|EnsemblGenome=HelroG192780|UniProtKB=T1FUA0 T1FUA0 20212396 PTHR39490:SF8 ARRESTIN DOMAIN-CONTAINING PROTEIN D ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 HELRO|EnsemblGenome=HelroG194983|UniProtKB=T1FWM4 T1FWM4 20213219 PTHR24347:SF427 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG69371|UniProtKB=T1FZU0 T1FZU0 20214338 PTHR45870:SF11 TUBULIN MONOGLYCYLASE TTLL3 TUBULIN MONOGLYCYLASE TTLL3 catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-nitrogen bonds#GO:0016879 sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;microtubule cytoskeleton organization#GO:0000226;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;sperm motility#GO:0097722;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;gamete generation#GO:0007276;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG172351|UniProtKB=T1F578 T1F578 20203977 PTHR10589:SF51 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of chromosome organization#GO:0033044 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG77067|UniProtKB=T1G2S9 T1G2S9 20215377 PTHR11003:SF346 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 18 voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857 monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG188784|UniProtKB=T1FQC8 T1FQC8 20211025 PTHR22692:SF33 MYOSIN VII, XV MYOSIN-VIIA actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG179786|UniProtKB=T1FF56 T1FF56 20207455 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184907|UniProtKB=T1FM58 T1FM58 20209907 PTHR24291:SF183 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 97B3, CHLOROPLASTIC oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG162949|UniProtKB=T1ETE7 T1ETE7 20199847 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163646|UniProtKB=T1EUB3 T1EUB3 20200163 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160158|UniProtKB=T1EPW7 T1EPW7 20198617 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG181073|UniProtKB=T1FGK9 T1FGK9 20207958 PTHR32026:SF29 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE 24-LIKE PROTEIN transferase#PC00220;methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185301|UniProtKB=T1FMM9 T1FMM9 20210078 PTHR11458:SF0 DELTA-AMINOLEVULINIC ACID DEHYDRATASE DELTA-AMINOLEVULINIC ACID DEHYDRATASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 porphyrin-containing compound biosynthetic process#GO:0006779;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;tetrapyrrole biosynthetic process#GO:0033014;cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091 Heme biosynthesis#P02746>porphobilinogen synthase#P02979 HELRO|EnsemblGenome=HelroG67615|UniProtKB=T1FZ29 T1FZ29 20214077 PTHR11711:SF427 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 14 nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein#PC00020 HELRO|EnsemblGenome=HelroG62918|UniProtKB=T1FX76 T1FX76 20213424 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER VERSICAN CORE PROTEIN molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG100710|UniProtKB=T1ED14 T1ED14 20194466 PTHR11246:SF5 PRE-MRNA SPLICING FACTOR PRE-MRNA-SPLICING FACTOR SYF1 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG77336|UniProtKB=T1G2W4 T1G2W4 20215412 PTHR11920:SF335 GUANYLYL CYCLASE GUANYLATE CYCLASE molecular transducer activity#GO:0060089;lyase activity#GO:0016829;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG68015|UniProtKB=T1FZ92 T1FZ92 20214140 PTHR13385:SF0 AUTOPHAGY PROTEIN 12 UBIQUITIN-LIKE PROTEIN ATG12 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;vacuole organization#GO:0007033;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;carbohydrate metabolic process#GO:0005975;protein-containing complex disassembly#GO:0032984;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;glycogen catabolic process#GO:0005980;macroautophagy#GO:0016236;cellular component disassembly#GO:0022411;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component assembly#GO:0022607 autophagosome#GO:0005776;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG113553|UniProtKB=T1EFT5 T1EFT5 20195437 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG156242|UniProtKB=T1ELT3 T1ELT3 20197533 PTHR11886:SF2 DYNEIN LIGHT CHAIN DYNEIN AXONEMAL LIGHT CHAIN 4 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG104700|UniProtKB=T1EDN2 T1EDN2 20194684 PTHR21367:SF1 ARGININE-TRNA-PROTEIN TRANSFERASE 1 ARGINYL-TRNA--PROTEIN TRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a protein#GO:0140096;catalytic activity, acting on RNA#GO:0140098;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;catalytic activity, acting on a tRNA#GO:0140101 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translational protein#PC00263 HELRO|EnsemblGenome=HelroG192345|UniProtKB=T1FTU6 T1FTU6 20212243 PTHR13227:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 2A EUKARYOTIC TRANSLATION INITIATION FACTOR 2A translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 Gonadotropin-releasing hormone receptor pathway#P06664>EIF2A#P06762 HELRO|EnsemblGenome=HelroG186656|UniProtKB=T1FP20 T1FP20 20210567 PTHR22692:SF33 MYOSIN VII, XV MYOSIN-VIIA actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG185115|UniProtKB=T1FME8 T1FME8 20209997 PTHR19278:SF9 OROTATE PHOSPHORIBOSYLTRANSFERASE URIDINE 5'-MONOPHOSPHATE SYNTHASE lyase activity#GO:0016829;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;transferase activity#GO:0016740;carboxy-lyase activity#GO:0016831 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;pyrimidine nucleobase metabolic process#GO:0006206;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;pyrimidine-containing compound metabolic process#GO:0072527;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 transferase#PC00220;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Orotate phosphoribosyltransferase#P02922 HELRO|EnsemblGenome=HelroG180188|UniProtKB=T1FFK1 T1FFK1 20207600 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG95171|UniProtKB=T1G948 T1G948 20217595 PTHR12961:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2 transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;COG complex#GO:0017119 HELRO|EnsemblGenome=HelroG125565|UniProtKB=T1EH66 T1EH66 20195916 PTHR10270:SF161 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG80042|UniProtKB=T1G3W8 T1G3W8 20215766 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188606|UniProtKB=T1FQ63 T1FQ63 20210960 PTHR16007:SF15 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B-LIKE HELRO|EnsemblGenome=HelroG177337|UniProtKB=T1FBJ0 T1FBJ0 20206189 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG81228|UniProtKB=T1G4B8 T1G4B8 20215916 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C4 zinc finger nuclear receptor#PC00169 HELRO|EnsemblGenome=HelroG194796|UniProtKB=T1FWF2 T1FWF2 20213147 PTHR46575:SF1 AMYLOID PROTEIN-BINDING PROTEIN 2 AMYLOID PROTEIN-BINDING PROTEIN 2 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG173789|UniProtKB=T1F783 T1F783 20204682 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG101065|UniProtKB=T1ED28 T1ED28 20194480 PTHR21646:SF122 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG169139|UniProtKB=T1F1G3 T1F1G3 20202663 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188868|UniProtKB=T1FQF2 T1FQF2 20211049 PTHR31543:SF0 DYNEIN REGULATORY COMPLEX SUBUNIT 4 DYNEIN REGULATORY COMPLEX SUBUNIT 4 cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;regulation of signaling#GO:0023051;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;positive regulation of response to stimulus#GO:0048584;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;plasma membrane bounded cell projection assembly#GO:0120031;regulation of response to stimulus#GO:0048583 plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;Golgi apparatus#GO:0005794;microtubule organizing center#GO:0005815;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG182052|UniProtKB=T1FHN6 T1FHN6 20208335 PTHR19282:SF516 TETRASPANIN LEUKOCYTE ANTIGEN CD37 ISOFORM X1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG133683|UniProtKB=T1EI24 T1EI24 20196224 PTHR24171:SF15 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50-RELATED HELRO|EnsemblGenome=HelroG66958|UniProtKB=T1FYT8 T1FYT8 20213986 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG113995|UniProtKB=T1EFY0 T1EFY0 20195482 PTHR23205:SF0 SPLICING FACTOR 3A SUBUNIT 2 SPLICING FACTOR 3A SUBUNIT 2 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG88652|UniProtKB=T1G750 T1G750 20216897 PTHR20854:SF4 INOSITOL MONOPHOSPHATASE INOSITOL-1-MONOPHOSPHATASE-RELATED phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG161493|UniProtKB=T1ERJ7 T1ERJ7 20199197 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG156810|UniProtKB=T1EM15 T1EM15 20197615 PTHR11817:SF3 PYRUVATE KINASE AT14039P-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;pyruvate kinase activity#GO:0004743 purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;ADP catabolic process#GO:0046032;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HELRO|EnsemblGenome=HelroG144193|UniProtKB=T1EJD8 T1EJD8 20196688 PTHR13058:SF22 THREE PRIME REPAIR EXONUCLEASE 1, 2 EXODEOXYRIBONUCLEASE III exonuclease activity#GO:0004527;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on DNA#GO:0140097 catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA catabolic process#GO:0006308;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG184274|UniProtKB=T1FKW4 T1FKW4 20209463 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG185444|UniProtKB=T1FMU1 T1FMU1 20210140 PTHR13242:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG188989|UniProtKB=T1FQJ3 T1FQJ3 20211090 PTHR46896:SF3 SENTRIN-SPECIFIC PROTEASE FI06413P-RELATED protease#PC00190;cysteine protease#PC00081 HELRO|EnsemblGenome=HelroG112262|UniProtKB=T1EFI2 T1EFI2 20195334 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS HOMEOTIC PROTEIN FEMALE STERILE-RELATED chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG85448|UniProtKB=T1G5X2 T1G5X2 20216469 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG76712|UniProtKB=T1G2N1 T1G2N1 20215329 PTHR12703:SF4 TRANSMEMBRANE PROTEIN 33 TRANSMEMBRANE PROTEIN 33 nuclear envelope organization#GO:0006998;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum membrane organization#GO:0090158;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum tubular network organization#GO:0071786;endoplasmic reticulum organization#GO:0007029;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG86512|UniProtKB=T1G6D4 T1G6D4 20216631 PTHR45617:SF171 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG135367|UniProtKB=T1EI82 T1EI82 20196283 PTHR11636:SF76 POU DOMAIN PROTEIN NUBBIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG94284|UniProtKB=T1G8Z9 T1G8Z9 20217546 PTHR12940:SF0 ES-2 PROTEIN - RELATED SPLICING FACTOR ESS-2 HOMOLOG organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG90377|UniProtKB=T1G7Q3 T1G7Q3 20217100 PTHR11654:SF678 OLIGOPEPTIDE TRANSPORTER-RELATED PEPTIDE TRANSPORTER FAMILY 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;oligopeptide transmembrane transporter activity#GO:0035673;dipeptide transmembrane transporter activity#GO:0071916 import across plasma membrane#GO:0098739;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;oligopeptide transport#GO:0006857;localization#GO:0051179;dipeptide transport#GO:0042938;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;import into cell#GO:0098657;transport#GO:0006810 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG111410|UniProtKB=T1EFB0 T1EFB0 20195262 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER FI24011P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG75327|UniProtKB=T1G237 T1G237 20215135 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;cellular process#GO:0009987;nervous system development#GO:0007399;protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;cell adhesion#GO:0007155;receptor clustering#GO:0043113;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;macromolecule localization#GO:0033036;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;developmental process#GO:0032502;intracellular protein localization#GO:0008104;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;establishment or maintenance of apical/basal cell polarity#GO:0035088;trans-synaptic signaling#GO:0099537;protein localization to cell junction#GO:1902414;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;anatomical structure development#GO:0048856;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;neuromuscular junction#GO:0031594;synaptic membrane#GO:0097060;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185626|UniProtKB=T1FN22 T1FN22 20210221 PTHR11937:SF155 ACTIN ACTIN-RELATED PROTEIN 1 structural molecule activity#GO:0005198;protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;structural constituent of cytoskeleton#GO:0005200;cytoskeletal adaptor activity#GO:0008093 nuclear migration#GO:0007097;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 actin and actin related protein#PC00039 Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090 HELRO|EnsemblGenome=HelroG191744|UniProtKB=T1FT92 T1FT92 20212039 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG143032|UniProtKB=T1EJ87 T1EJ87 20196637 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;regulation of cell cycle G2/M phase transition#GO:1902749;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G2/M phase transition#GO:0044839;regulation of reproductive process#GO:2000241;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cell cycle process#GO:0022402;regulation of meiotic cell cycle#GO:0051445;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of cell cycle#GO:0051726 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG104956|UniProtKB=T1EDP4 T1EDP4 20194696 PTHR48099:SF5 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;tetrahydrofolate metabolic process#GO:0046653;metabolic process#GO:0008152;tetrahydrofolate biosynthetic process#GO:0046654 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HELRO|EnsemblGenome=HelroG153381|UniProtKB=T1EL61 T1EL61 20197311 PTHR46289:SF24 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE HELRO|EnsemblGenome=HelroG104295|UniProtKB=T1EDK8 T1EDK8 20194660 PTHR45810:SF10 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HELRO|EnsemblGenome=HelroG184031|UniProtKB=T1FKG6 T1FKG6 20209315 PTHR42884:SF39 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 1 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;protein processing#GO:0016485;cellular process#GO:0009987;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;proteolysis#GO:0006508;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;neuron projection#GO:0043005;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 serine protease#PC00203 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG76057|UniProtKB=T1G2E4 T1G2E4 20215242 PTHR10736:SF70 BESTROPHIN BESTROPHIN HOMOLOG chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG70561|UniProtKB=T1G086 T1G086 20214484 PTHR15079:SF3 MYD88 MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-positive bacterium#GO:0050830;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune system process#GO:0002376;defense response to bacterium#GO:0042742;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;toll-like receptor 4 signaling pathway#GO:0034142;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>MyD88#P01377;Toll pathway-drosophila#P06217>MyD88#P06346 HELRO|EnsemblGenome=HelroG172964|UniProtKB=T1F680 T1F680 20204329 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG103256|UniProtKB=T1EDF2 T1EDF2 20194604 PTHR23142:SF1 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38A RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG101627|UniProtKB=T1ED60 T1ED60 20194512 PTHR20938:SF0 INTEGRATOR COMPLEX SUBUNIT 4 INTEGRATOR COMPLEX SUBUNIT 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 snRNA 3'-end processing#GO:0034472;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;transcription initiation at RNA polymerase II promoter#GO:0006367;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;transcription by RNA polymerase II#GO:0006366;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;integrator complex#GO:0032039;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG175490|UniProtKB=T1F9B6 T1F9B6 20205415 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG142296|UniProtKB=T1EJ54 T1EJ54 20196604 PTHR18945:SF948 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10-LIKE synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;trans-synaptic signaling#GO:0099537;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 ligand-gated ion channel#PC00141 HELRO|EnsemblGenome=HelroG78909|UniProtKB=T1G3H2 T1G3H2 20215620 PTHR13072:SF0 DYNACTIN 6 DYNACTIN SUBUNIT 6 binding#GO:0005488;protein-containing complex binding#GO:0044877 cell cycle process#GO:0022402;cellular process#GO:0009987;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629 microtubule binding motor protein#PC00156 HELRO|EnsemblGenome=HelroG185636|UniProtKB=T1FN26 T1FN26 20210225 PTHR23073:SF24 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 4 isomerase activity#GO:0016853;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 proteasome complex#GO:0000502;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG190606|UniProtKB=T1FS46 T1FS46 20211643 PTHR12480:SF19 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD CUPIN-LIKE DOMAIN-CONTAINING PROTEIN DNA binding#GO:0003677;dioxygenase activity#GO:0051213;binding#GO:0005488;nucleic acid binding#GO:0003676;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;sequence-specific DNA binding#GO:0043565;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of translation#GO:0045727;positive regulation of protein metabolic process#GO:0051247;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of protein-containing complex disassembly#GO:0043244;regulation of translation#GO:0006417;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG97558|UniProtKB=T1G9H6 T1G9H6 20217723 PTHR24006:SF644 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG181785|UniProtKB=T1FHB6 T1FHB6 20208215 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of catabolic process#GO:0009895;regulation of RNA stability#GO:0043487;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;developmental process#GO:0032502;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193301|UniProtKB=T1FUV0 T1FUV0 20212596 PTHR12394:SF12 ZYGIN LD08195P cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection#GO:0043005;axon#GO:0030424 HELRO|EnsemblGenome=HelroG190648|UniProtKB=T1FS61 T1FS61 20211658 PTHR33662:SF3 OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED FIBROUS SHEATH CABYR-BINDING PROTEIN ISOFORM X1-RELATED HELRO|EnsemblGenome=HelroG193598|UniProtKB=T1FV58 T1FV58 20212704 PTHR19212:SF0 LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN LD07988P gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG174847|UniProtKB=T1F8J3 T1F8J3 20205142 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG SPT20 HOMOLOG, SAGA COMPLEX COMPONENT-RELATED transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 chromatin#GO:0000785;SAGA complex#GO:0000124;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG68049|UniProtKB=T1FZ96 T1FZ96 20214144 PTHR24092:SF190 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;intramembrane lipid carrier activity#GO:0140303 regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;Golgi organization#GO:0007030;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;phospholipid translocation#GO:0045332;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid transport#GO:0015914;lipid transport#GO:0006869;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036 cell periphery#GO:0071944;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG90701|UniProtKB=T1G7U6 T1G7U6 20217143 PTHR22870:SF446 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG77242|UniProtKB=T1G2U9 T1G2U9 20215397 PTHR23339:SF129 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE CELL DIVISION CYCLE 14, ISOFORM A catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787 regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;organelle assembly#GO:0070925;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cellular component organization#GO:0016043;cilium assembly#GO:0060271;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of cell cycle#GO:0045787;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;cellular component assembly#GO:0022607 membraneless organelle#GO:0043228;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194579|UniProtKB=T1FW77 T1FW77 20213073 PTHR12374:SF63 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-BETA transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;binding#GO:0005488;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG62909|UniProtKB=T1FX73 T1FX73 20213421 PTHR11920:SF462 GUANYLYL CYCLASE GUANYLATE CYCLASE catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 lyase#PC00144;guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG189498|UniProtKB=T1FR37 T1FR37 20211284 PTHR13140:SF880 MYOSIN DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;microfilament motor activity#GO:0000146 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;actin cytoskeleton#GO:0015629 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG166756|UniProtKB=T1EYH0 T1EYH0 20201620 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162972|UniProtKB=T1ETG7 T1ETG7 20199867 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG193907|UniProtKB=T1FVG8 T1FVG8 20212814 PTHR24093:SF535 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG160179|UniProtKB=T1EPX6 T1EPX6 20198626 PTHR45080:SF48 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 cell body#GO:0044297;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;axon#GO:0030424 HELRO|EnsemblGenome=HelroG86051|UniProtKB=T1G667 T1G667 20216564 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG180798|UniProtKB=T1FGA5 T1FGA5 20207854 PTHR45889:SF8 IG-LIKE DOMAIN-CONTAINING PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174236|UniProtKB=T1F7U7 T1F7U7 20204896 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72721|UniProtKB=T1G143 T1G143 20214791 PTHR24247:SF267 5-HYDROXYTRYPTAMINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169894|UniProtKB=T1F2F0 T1F2F0 20203000 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG93730|UniProtKB=T1G8X5 T1G8X5 20217522 PTHR44360:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 9 DNAJ HOMOLOG SUBFAMILY B MEMBER 9 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 HELRO|EnsemblGenome=HelroG185829|UniProtKB=T1FNC4 T1FNC4 20210321 PTHR19370:SF219 NADH-CYTOCHROME B5 REDUCTASE NADH-CYTOCHROME B5 REDUCTASE nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H#GO:0016651;binding#GO:0005488;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG70815|UniProtKB=T1G0C6 T1G0C6 20214524 PTHR24208:SF128 LIM/HOMEOBOX PROTEIN LHX LIM3, ISOFORM G transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG188276|UniProtKB=T1FPT8 T1FPT8 20210835 PTHR12387:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 proteasome regulatory particle, lid subcomplex#GO:0008541;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG156254|UniProtKB=T1ELT5 T1ELT5 20197535 PTHR10663:SF402 GUANYL-NUCLEOTIDE EXCHANGE FACTOR MIP16918P membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG170597|UniProtKB=T1F381 T1F381 20203280 PTHR23113:SF249 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;system development#GO:0048731;Ras protein signal transduction#GO:0007265 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 guanyl-nucleotide exchange factor#PC00113 HELRO|EnsemblGenome=HelroG192481|UniProtKB=T1FU03 T1FU03 20212299 PTHR10334:SF629 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG185252|UniProtKB=T1FMK2 T1FMK2 20210051 PTHR19957:SF411 SYNTAXIN LD23667P SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;membrane fusion#GO:0061025;macromolecule localization#GO:0033036 presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cell junction#GO:0030054;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HELRO|EnsemblGenome=HelroG188015|UniProtKB=T1FPJ8 T1FPJ8 20210745 PTHR12958:SF3 FRIEND OF GATA2-RELATED ZINC FINGER PROTEIN USH transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription factor binding#GO:0008134;binding#GO:0005488;transcription regulator activity#GO:0140110;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;animal gross anatomical part developmental process#GO:0160108;heart development#GO:0007507;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG167008|UniProtKB=T1EYW2 T1EYW2 20201762 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115984|UniProtKB=T1EGC3 T1EGC3 20195625 PTHR19288:SF93 4-NITROPHENYLPHOSPHATASE-RELATED FI11325P-RELATED hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG144663|UniProtKB=T1EJF6 T1EJF6 20196706 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177485|UniProtKB=T1FBR9 T1FBR9 20206268 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG173605|UniProtKB=T1F711 T1F711 20204610 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG173887|UniProtKB=T1F7C1 T1F7C1 20204720 PTHR11239:SF14 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription by RNA polymerase I#GO:0006360;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase I complex#GO:0005736;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233 DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG116255|UniProtKB=T1EGD8 T1EGD8 20195640 PTHR24241:SF161 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG177493|UniProtKB=T1FBS5 T1FBS5 20206274 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG81592|UniProtKB=T1G4G1 T1G4G1 20215959 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;steroid hydroxylase activity#GO:0008395;binding#GO:0005488;tetrapyrrole binding#GO:0046906 primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to chemical#GO:0042221;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxygenase#PC00177 HELRO|EnsemblGenome=HelroG192210|UniProtKB=T1FTP6 T1FTP6 20212193 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG150089|UniProtKB=T1EKE4 T1EKE4 20197044 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG75022|UniProtKB=T1G1Z4 T1G1Z4 20215092 PTHR23338:SF18 SMALL NUCLEAR RIBONUCLEOPROTEIN SM SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;U2 snRNP#GO:0005686;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;cytoplasm#GO:0005737;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U4 snRNP#GO:0005687;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG108526|UniProtKB=T1EEJ8 T1EEJ8 20195000 PTHR47958:SF11 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386 developmental process#GO:0032502;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular process#GO:0009987;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG191654|UniProtKB=T1FT64 T1FT64 20212011 PTHR23216:SF2 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG174804|UniProtKB=T1F8H9 T1F8H9 20205128 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG156580|UniProtKB=T1ELY7 T1ELY7 20197587 PTHR23073:SF13 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 7 catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;isomerase activity#GO:0016853 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;proteasome complex#GO:0000502;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG71906|UniProtKB=T1G0S8 T1G0S8 20214676 PTHR10943:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 proteasome complex#GO:0000502;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;cytoplasm#GO:0005737;endopeptidase complex#GO:1905369;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG109284|UniProtKB=T1EES1 T1EES1 20195073 PTHR13465:SF4 UPF0183 PROTEIN PHAF1 PROTEIN CG7083 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;Golgi vesicle transport#GO:0048193;transport#GO:0006810;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;localization#GO:0051179;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668 trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HELRO|EnsemblGenome=HelroG187164|UniProtKB=T1FP74 T1FP74 20210621 PTHR42881:SF2 PROLYL ENDOPEPTIDASE PROLYL ENDOPEPTIDASE peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 Vasopressin synthesis#P04395>Endo Peptidase#P04596 HELRO|EnsemblGenome=HelroG189358|UniProtKB=T1FR00 T1FR00 20211247 PTHR44461:SF1 QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1 FERRY ENDOSOMAL RAB5 EFFECTOR COMPLEX SUBUNIT 4 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG83724|UniProtKB=T1G596 T1G596 20216243 PTHR42985:SF49 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER GH20226P active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;symporter activity#GO:0015293 metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;sodium ion transport#GO:0006814;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG117052|UniProtKB=T1EGJ7 T1EGJ7 20195699 PTHR24099:SF15 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM9 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection development#GO:0031175;axon development#GO:0061564;axon guidance#GO:0007411;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron differentiation#GO:0030182;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191226|UniProtKB=T1FSR5 T1FSR5 20211862 PTHR11675:SF68 N-ACETYLGALACTOSAMINYLTRANSFERASE N-ACETYLGALACTOSAMINYLTRANSFERASE 7 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 glycosyltransferase#PC00111;transferase#PC00220 HELRO|EnsemblGenome=HelroG113810|UniProtKB=T1EFX0 T1EFX0 20195472 PTHR19134:SF570 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HELRO|EnsemblGenome=HelroG65888|UniProtKB=T1FYE2 T1FYE2 20213840 PTHR10281:SF4 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED NEUFERRICIN cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG107565|UniProtKB=T1EEB3 T1EEB3 20194915 PTHR23235:SF161 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KLU-2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG81819|UniProtKB=T1G4J1 T1G4J1 20215989 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG85076|UniProtKB=T1G5S5 T1G5S5 20216422 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT DIMERIZATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190889|UniProtKB=T1FSE2 T1FSE2 20211739 PTHR10997:SF7 IMPORTIN-7, 8, 11 IMPORTIN-11 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 nucleus#GO:0005634;organelle envelope#GO:0031967;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG193051|UniProtKB=T1FUK6 T1FUK6 20212502 PTHR12131:SF34 ATP-DEPENDENT RNA AND DNA HELICASE SUPERKILLER COMPLEX PROTEIN 2 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185749|UniProtKB=T1FN86 T1FN86 20210284 PTHR11774:SF6 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transferase complex#GO:1990234;catalytic complex#GO:1902494 acyltransferase#PC00042;transferase#PC00220 HELRO|EnsemblGenome=HelroG184656|UniProtKB=T1FLP5 T1FLP5 20209744 PTHR47160:SF13 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84585|UniProtKB=T1G5K6 T1G5K6 20216353 PTHR24046:SF7 SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2 cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;cellular developmental process#GO:0048869;response to endogenous stimulus#GO:0009719;muscle cell development#GO:0055001;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;muscle cell differentiation#GO:0042692;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;cell development#GO:0048468;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;smoothened signaling pathway#GO:0007224 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG155902|UniProtKB=T1ELP0 T1ELP0 20197490 PTHR12111:SF2 SPLICING FACTOR YJU2 SPLICING FACTOR YJU2B-RELATED ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231 RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG188557|UniProtKB=T1FQ43 T1FQ43 20210940 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 5 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91842|UniProtKB=T1G897 T1G897 20217294 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG159228|UniProtKB=T1ENR8 T1ENR8 20198218 PTHR23227:SF86 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165939|UniProtKB=T1EXH4 T1EXH4 20201274 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG71473|UniProtKB=T1G0M1 T1G0M1 20214619 PTHR12735:SF27 BOLA-LIKE PROTEIN-RELATED BOLA-LIKE PROTEIN 2 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG169786|UniProtKB=T1F2B6 T1F2B6 20202966 PTHR46478:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A HELRO|EnsemblGenome=HelroG101913|UniProtKB=T1ED75 T1ED75 20194527 PTHR10519:SF77 GABA-B RECEPTOR GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular process#GO:0009987;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;signaling receptor complex#GO:0043235 G-protein coupled receptor#PC00021 GABA-B receptor II signaling#P05731>GABA-B receptor#P05756 HELRO|EnsemblGenome=HelroG186162|UniProtKB=T1FNR1 T1FNR1 20210458 PTHR11353:SF26 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT DELTA macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cytosol#GO:0005829;chaperonin-containing T-complex#GO:0005832;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein folding chaperone complex#GO:0101031 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG156619|UniProtKB=T1ELZ0 T1ELZ0 20197590 PTHR42861:SF102 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;metal ion transport#GO:0030001;homeostatic process#GO:0042592;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074 membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG180792|UniProtKB=T1FGA2 T1FGA2 20207851 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155881|UniProtKB=T1ELN6 T1ELN6 20197486 PTHR10261:SF0 COATOMER SUBUNIT GAMMA COATOMER SUBUNIT GAMMA-2 Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;COPI-coated vesicle#GO:0030137;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG73542|UniProtKB=T1G1F6 T1G1F6 20214904 PTHR23245:SF31 TRNA METHYLTRANSFERASE TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3 HOMOLOG catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;methylation#GO:0032259;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG164780|UniProtKB=T1EVT1 T1EVT1 20200681 PTHR12390:SF0 UROPORPHYRINOGEN III SYNTHASE UROPORPHYRINOGEN-III SYNTHASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;tetrapyrrole biosynthetic process#GO:0033014;porphyrin-containing compound metabolic process#GO:0006778;small molecule biosynthetic process#GO:0044283;tetrapyrrole metabolic process#GO:0033013;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;porphyrin-containing compound biosynthetic process#GO:0006779 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Heme biosynthesis#P02746>Uroporphyrinogen-III synthase#P02974 HELRO|EnsemblGenome=HelroG174815|UniProtKB=T1F8I3 T1F8I3 20205132 PTHR13328:SF7 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG167081|UniProtKB=T1EZ00 T1EZ00 20201800 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176307|UniProtKB=T1FAD7 T1FAD7 20205786 PTHR14445:SF46 GRB10 INTERACTING GYF PROTEIN SUBFAMILY NOT NAMED translation regulator activity#GO:0045182 post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163212|UniProtKB=T1ETT2 T1ETT2 20199982 PTHR13723:SF320 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE GON DOMAIN-CONTAINING PROTEIN metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 metalloprotease#PC00153 HELRO|EnsemblGenome=HelroG114400|UniProtKB=T1EG14 T1EG14 20195516 PTHR14074:SF39 HELICASE WITH DEATH DOMAIN-RELATED FANCONI ANEMIA GROUP M PROTEIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG64229|UniProtKB=T1FXR6 T1FXR6 20213614 PTHR14003:SF37 TRANSCRIPTIONAL REPRESSOR PROTEIN YY YY2 TRANSCRIPTION FACTOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cell development#GO:0048468;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 chromosome#GO:0005694;PcG protein complex#GO:0031519;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG165595|UniProtKB=T1EX20 T1EX20 20201120 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188417|UniProtKB=T1FPZ0 T1FPZ0 20210887 PTHR13318:SF292 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6, ISOFORM A-RELATED modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HELRO|EnsemblGenome=HelroG99505|UniProtKB=T1G9T1 T1G9T1 20217827 PTHR24409:SF441 ZINC FINGER PROTEIN 142 TRANSCRIPTIONAL REPRESSOR CTCF transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HELRO|EnsemblGenome=HelroG83731|UniProtKB=T1G598 T1G598 20216245 PTHR24031:SF706 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX27-RELATED ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG164127|UniProtKB=T1EUZ1 T1EUZ1 20200391 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;endoribonuclease#PC00094 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG164257|UniProtKB=T1EV62 T1EV62 20200462 PTHR23151:SF94 DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;acetyl-CoA metabolic process#GO:0006084;pyruvate metabolic process#GO:0006090;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790 oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493 acetyltransferase#PC00038;transferase#PC00220 HELRO|EnsemblGenome=HelroG189974|UniProtKB=T1FRJ8 T1FRJ8 20211445 PTHR12630:SF6 N-LINKED OLIGOSACCHARIDE PROCESSING N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNIT GAMMA glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG171484|UniProtKB=T1F4C5 T1F4C5 20203674 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY NR LBD DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG63271|UniProtKB=T1FXD3 T1FXD3 20217407 PTHR23431:SF3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;zinc ion binding#GO:0008270;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription by RNA polymerase I#GO:0006360;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA metabolism protein#PC00009 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG109498|UniProtKB=T1EEU2 T1EEU2 20195094 PTHR14614:SF44 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN N-LYSINE METHYLTRANSFERASE METTL21D lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179232|UniProtKB=T1FEE4 T1FEE4 20207193 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG67130|UniProtKB=T1FYW9 T1FYW9 20214017 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;epidermis development#GO:0008544;developmental process#GO:0032502 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176977|UniProtKB=T1FB32 T1FB32 20206031 PTHR31718:SF60 PLAT DOMAIN-CONTAINING PROTEIN LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG193118|UniProtKB=T1FUN1 T1FUN1 20212527 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83279|UniProtKB=T1G533 T1G533 20216181 PTHR20648:SF0 ELONGIN-C ELONGIN-C molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG88819|UniProtKB=T1G768 T1G768 20216915 PTHR24038:SF11 STABILIN INTEGRIN BETA-LIKE PROTEIN E membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG160685|UniProtKB=T1EQL4 T1EQL4 20198864 PTHR28642:SF1 MEIOSIS 1 ARREST PROTEIN MEIOSIS 1 ARREST PROTEIN organelle fission#GO:0048285;multicellular organismal reproductive process#GO:0048609;nuclear division#GO:0000280;sexual reproduction#GO:0019953;gamete generation#GO:0007276;reproductive process#GO:0022414;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;chromosome separation#GO:0051304;meiotic nuclear division#GO:0140013;meiotic chromosome segregation#GO:0045132;meiotic cell cycle#GO:0051321;spermatogenesis#GO:0007283;chromosome segregation#GO:0007059;developmental process#GO:0032502;male gamete generation#GO:0048232;male meiotic nuclear division#GO:0007140;organelle organization#GO:0006996;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG184315|UniProtKB=T1FKZ1 T1FKZ1 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164068|UniProtKB=T1EUV4 T1EUV4 20200354 PTHR15718:SF3 G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular process#GO:0009987;neuron projection development#GO:0031175;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG167542|UniProtKB=T1EZG9 T1EZG9 20201969 PTHR13465:SF4 UPF0183 PROTEIN PHAF1 PROTEIN CG7083 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;protein localization to cell periphery#GO:1990778;transport#GO:0006810;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG182787|UniProtKB=T1FIQ5 T1FIQ5 20208704 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;cellular anatomical entity morphogenesis#GO:0032989;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;system process#GO:0003008;cellular developmental process#GO:0048869;developmental process#GO:0032502;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle cell development#GO:0055001 organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;contractile muscle fiber#GO:0043292;sarcomere#GO:0030017;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG110176|UniProtKB=T1EF02 T1EF02 20195154 PTHR43272:SF111 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;neurogenesis#GO:0022008;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;neuron differentiation#GO:0030182;developmental process#GO:0032502;lipid metabolic process#GO:0006629;multicellular organismal process#GO:0032501;nucleobase-containing compound metabolic process#GO:0006139;nervous system development#GO:0007399;organophosphate metabolic process#GO:0019637;long-chain fatty acid metabolic process#GO:0001676;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;oxoacid metabolic process#GO:0043436;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lipid droplet#GO:0005811;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligase#PC00142 HELRO|EnsemblGenome=HelroG170427|UniProtKB=T1F316 T1F316 20203215 PTHR43333:SF1 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN PUTATIVE-RELATED HELRO|EnsemblGenome=HelroG194134|UniProtKB=T1FVQ6 T1FVQ6 20212902 PTHR13859:SF11 ATROPHIN-RELATED GRUNGE, ISOFORM J transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG172941|UniProtKB=T1F664 T1F664 20204313 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67881|UniProtKB=T1FZ69 T1FZ69 20214117 PTHR22878:SF63 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN HEAVY CHAIN 10, AXONEMAL Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG175930|UniProtKB=T1F9X1 T1F9X1 20205620 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG180856|UniProtKB=T1FGC2 T1FGC2 20207871 PTHR43170:SF5 GMP REDUCTASE GMP REDUCTASE reductase#PC00198;oxidoreductase#PC00176 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HELRO|EnsemblGenome=HelroG90190|UniProtKB=T1G7M1 T1G7M1 20217068 PTHR12277:SF204 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PALMITOYL-PROTEIN HYDROLASE thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;palmitoyl hydrolase activity#GO:0098599;catalytic activity, acting on a protein#GO:0140096 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 serine protease#PC00203 HELRO|EnsemblGenome=HelroG84318|UniProtKB=T1G5H5 T1G5H5 20216322 PTHR14094:SF9 SIGNAL RECOGNITION PARTICLE 72 SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72 ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;nucleic acid binding#GO:0003676;binding#GO:0005488 protein targeting to membrane#GO:0006612;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;localization within membrane#GO:0051668;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;protein targeting to ER#GO:0045047;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605;establishment of protein localization to endoplasmic reticulum#GO:0072599 ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG107544|UniProtKB=T1EEB1 T1EEB1 20194913 PTHR43721:SF9 ELONGATION FACTOR TU-RELATED GTP-BINDING PROTEIN 1 translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG65386|UniProtKB=T1FY70 T1FY70 20213768 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HELRO|EnsemblGenome=HelroG176552|UniProtKB=T1FAN1 T1FAN1 20205880 PTHR46984:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71 HELRO|EnsemblGenome=HelroG168981|UniProtKB=T1F178 T1F178 20202578 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN DUF659 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188214|UniProtKB=T1FPS3 T1FPS3 20210820 PTHR15065:SF4 INSULINOMA-ASSOCIATED 1 LD18634P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cell cycle#GO:0051726;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;regulation of cell cycle process#GO:0010564;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;neuron differentiation#GO:0030182 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG185120|UniProtKB=T1FMF3 T1FMF3 20210002 PTHR10540:SF6 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F hydrolase activity#GO:0016787;protein binding#GO:0005515;deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237;binding#GO:0005488;translation initiation factor activity#GO:0003743;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;translation initiation factor binding#GO:0031369;catalytic activity, acting on a protein#GO:0140096;translation factor activity#GO:0180051;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation initiation factor#PC00224 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG178192|UniProtKB=T1FCX1 T1FCX1 20206670 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76627|UniProtKB=T1G2M3 T1G2M3 20215321 PTHR11216:SF1 EH DOMAIN SARCALUMENIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular localization#GO:0051641;endosomal transport#GO:0016197 cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG63277|UniProtKB=T1FXD5 T1FXD5 20213483 PTHR11309:SF47 FRIZZLED FRIZZLED binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Angiogenesis#P00005>Fzd#P00189;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG185118|UniProtKB=T1FMF1 T1FMF1 20210000 PTHR22599:SF74 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR-LIKE 1 kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;hippo signaling#GO:0035329;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG167799|UniProtKB=T1EZT8 T1EZT8 20202088 PTHR31802:SF53 32 KDA HEAT SHOCK PROTEIN-RELATED SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162338|UniProtKB=T1ESI8 T1ESI8 20199538 PTHR11601:SF65 CYSTEINE DESULFURYLASE FAMILY MEMBER CYSTEINE DESULFURASE sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;nucleus#GO:0005634;cytosol#GO:0005829 lyase#PC00144;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG91402|UniProtKB=T1G832 T1G832 20217229 PTHR23423:SF17 ORGANIC SOLUTE TRANSPORTER-RELATED IP17403P transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG174321|UniProtKB=T1F800 T1F800 20204949 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186759|UniProtKB=T1FP30 T1FP30 20210577 PTHR15092:SF37 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 TARGET OF EGR1 PROTEIN 1 RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA binding#GO:0003723;hydrolase activity#GO:0016787;snRNA binding#GO:0017069;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nucleic acid binding#GO:0003676;binding#GO:0005488 snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG159110|UniProtKB=T1ENL9 T1ENL9 20198169 PTHR10265:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 1 DACAPO molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 negative regulation of cell cycle#GO:0045786;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;negative regulation of mitotic cell cycle phase transition#GO:1901991;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG177018|UniProtKB=T1FB54 T1FB54 20206053 PTHR31144:SF1 UPF0602 PROTEIN C4ORF47 CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96 microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG87437|UniProtKB=T1G6Q0 T1G6Q0 20216747 PTHR24322:SF755 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HELRO|EnsemblGenome=HelroG99594|UniProtKB=T1G9T9 T1G9T9 20217835 PTHR13140:SF870 MYOSIN MYOSIN HEAVY CHAIN 95F cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 actin filament-based movement#GO:0030048;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell periphery#GO:0071944;membrane#GO:0016020;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;actin cytoskeleton#GO:0015629 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG107160|UniProtKB=T1EE81 T1EE81 20194883 PTHR23346:SF7 TRANSLATIONAL ACTIVATOR GCN1-RELATED STALLED RIBOSOME SENSOR GCN1 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;cellular process#GO:0009987;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;cellular response to amino acid starvation#GO:0034198;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80560|UniProtKB=T1G421 T1G421 20215819 PTHR43416:SF5 DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;cellular process#GO:0009987 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220 HELRO|EnsemblGenome=HelroG62767|UniProtKB=T1FX50 T1FX50 20213398 PTHR45867:SF3 PURPLE ACID PHOSPHATASE ACID PHOSPHATASE TYPE 7 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG71510|UniProtKB=T1G0M4 T1G0M4 20214622 PTHR10845:SF259 REGULATOR OF G PROTEIN SIGNALING RGS DOMAIN-CONTAINING PROTEIN-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047 negative regulation of cell communication#GO:0010648;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG174937|UniProtKB=T1F8M9 T1F8M9 20205178 PTHR21538:SF24 ANILLIN/RHOTEKIN RTKN PH DOMAIN-CONTAINING PROTEIN cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;actomyosin contractile ring assembly#GO:0000915;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;septin cytoskeleton organization#GO:0032185;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;cell division#GO:0051301;septin ring organization#GO:0031106;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;cytokinetic process#GO:0032506 cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cell periphery#GO:0071944;membraneless organelle#GO:0043228;contractile ring#GO:0070938;cytoskeleton#GO:0005856;actomyosin contractile ring#GO:0005826;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG175878|UniProtKB=T1F9T6 T1F9T6 20205585 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100690|UniProtKB=T1ED13 T1ED13 20194465 PTHR16172:SF2 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE JET FUEL, ISOFORM A membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG173501|UniProtKB=T1F6W6 T1F6W6 20204565 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 HELRO|EnsemblGenome=HelroG169962|UniProtKB=T1F2H5 T1F2H5 20203025 PTHR19282:SF565 TETRASPANIN TETRASPANIN-14 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179696|UniProtKB=T1FF15 T1FF15 20207414 PTHR46652:SF3 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 HELRO|EnsemblGenome=HelroG64519|UniProtKB=T1FXV8 T1FXV8 20213656 PTHR13374:SF3 DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG DET1 HOMOLOG protein binding#GO:0005515;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;enzyme binding#GO:0019899;ubiquitin protein ligase binding#GO:0031625;molecular adaptor activity#GO:0060090;ubiquitin-like protein ligase binding#GO:0044389;enzyme-substrate adaptor activity#GO:0140767 positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;protein ubiquitination#GO:0016567;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of protein metabolic process#GO:0051247;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of metabolic process#GO:0009893 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG67935|UniProtKB=T1FZ81 T1FZ81 20214129 PTHR11200:SF303 INOSITOL 5-PHOSPHATASE EG:86E4.5 PROTEIN phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 membrane#GO:0016020;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG179781|UniProtKB=T1FF53 T1FF53 20207452 PTHR48515:SF3 CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194670|UniProtKB=T1FWA7 T1FWA7 20213103 PTHR10337:SF6 SHC TRANSFORMING PROTEIN CENTROSOMAL PROTEIN OF 152 KDA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;centriole replication#GO:0007099;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG95968|UniProtKB=T1G993 T1G993 20217640 PTHR11082:SF5 TRNA-DIHYDROURIDINE SYNTHASE TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG81736|UniProtKB=T1G4I1 T1G4I1 20215979 PTHR21490:SF0 ENKURIN-RELATED ENKURIN binding#GO:0005488;calmodulin binding#GO:0005516;protein binding#GO:0005515 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;secretory vesicle#GO:0099503;microtubule cytoskeleton#GO:0015630;axoneme#GO:0005930;microtubule#GO:0005874;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;cilium#GO:0005929;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HELRO|EnsemblGenome=HelroG163763|UniProtKB=T1EUF8 T1EUF8 20200208 PTHR13703:SF54 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;molecular function regulator activity#GO:0098772;sequence-specific double-stranded DNA binding#GO:1990837;molecular function inhibitor activity#GO:0140678;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>RSmads#P01292 HELRO|EnsemblGenome=HelroG171506|UniProtKB=T1F4C9 T1F4C9 20203678 PTHR10912:SF7 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metabolite interconversion enzyme#PC00262;cyclase#PC00079 HELRO|EnsemblGenome=HelroG169449|UniProtKB=T1F1Y2 T1F1Y2 20202832 PTHR15868:SF0 SIMILAR TO RIKEN CDNA 6430571L13 GENE, SIMILAR TO G20 PROTEIN SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 18 HELRO|EnsemblGenome=HelroG169662|UniProtKB=T1F274 T1F274 20202924 PTHR10882:SF0 DIPHTHINE SYNTHASE DIPHTHINE METHYL ESTER SYNTHASE methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG100648|UniProtKB=T1ED10 T1ED10 20194462 PTHR45623:SF9 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD3 ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;ATP hydrolysis activity#GO:0016887;DNA binding#GO:0003677;hydrolase activity#GO:0016787;histone binding#GO:0042393;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG179714|UniProtKB=T1FF23 T1FF23 20207422 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A cellular component organization#GO:0016043;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 leading edge membrane#GO:0031256;neuron projection membrane#GO:0032589;cell projection membrane#GO:0031253;cell leading edge#GO:0031252;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG155669|UniProtKB=T1ELK2 T1ELK2 20197452 PTHR11006:SF124 PROTEIN ARGININE N-METHYLTRANSFERASE ARGININE METHYLTRANSFERASE 9-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;histone modifying activity#GO:0140993;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107863|UniProtKB=T1EED4 T1EED4 20194936 PTHR11071:SF593 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 chaperone#PC00072 HELRO|EnsemblGenome=HelroG166730|UniProtKB=T1EYF9 T1EYF9 20201609 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174769|UniProtKB=T1F8G1 T1F8G1 20205110 PTHR13287:SF2 ADIPOSE-SECRETED SIGNALING PROTEIN ADIPOSE-SECRETED SIGNALING PROTEIN regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG65557|UniProtKB=T1FY96 T1FY96 20213794 PTHR45956:SF6 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG75595|UniProtKB=T1G268 T1G268 20215166 PTHR11384:SF59 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER LYSOSOMAL COBALAMIN TRANSPORTER ABCD4 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG169077|UniProtKB=T1F1D4 T1F1D4 20202634 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG182601|UniProtKB=T1FIG2 T1FIG2 20208611 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156647|UniProtKB=T1ELZ2 T1ELZ2 20197592 PTHR11476:SF7 HISTIDYL-TRNA SYNTHETASE HISTIDINE--TRNA LIGASE binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188964|UniProtKB=T1FQI5 T1FQI5 20211082 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cellular process#GO:0009987;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185503|UniProtKB=T1FMW6 T1FMW6 20210165 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG67067|UniProtKB=T1FYV8 T1FYV8 20214006 PTHR24346:SF74 MAP/MICROTUBULE AFFINITY-REGULATING KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG80592|UniProtKB=T1G424 T1G424 20215822 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG172587|UniProtKB=T1F5K1 T1F5K1 20204100 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED PROTEIN HAIRY RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG164756|UniProtKB=T1EVS0 T1EVS0 20200670 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN DIABLO protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG154876|UniProtKB=T1ELG3 T1ELG3 20197413 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 HELRO|EnsemblGenome=HelroG169354|UniProtKB=T1F1T9 T1F1T9 20202789 PTHR31954:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 structural protein#PC00211 HELRO|EnsemblGenome=HelroG158821|UniProtKB=T1ENB1 T1ENB1 20198061 PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG174099|UniProtKB=T1F7L6 T1F7L6 20204815 PTHR45080:SF48 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 axon#GO:0030424;cell projection#GO:0042995;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;cell body#GO:0044297;neuron projection#GO:0043005 HELRO|EnsemblGenome=HelroG181698|UniProtKB=T1FH87 T1FH87 20208186 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to stimulus#GO:0050896;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stress#GO:0006950 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG192478|UniProtKB=T1FU00 T1FU00 20212296 PTHR10411:SF8 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 FI09246P protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of JNK cascade#GO:0046328;positive regulation of MAPK cascade#GO:0043410;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell cycle#GO:0051726;regulation of cell communication#GO:0010646;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG63456|UniProtKB=T1FXG1 T1FXG1 20213509 PTHR13568:SF4 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 60 HELRO|EnsemblGenome=HelroG167939|UniProtKB=T1EZZ6 T1EZZ6 20202146 PTHR11081:SF70 FLAP ENDONUCLEASE FAMILY MEMBER FLAP ENDONUCLEASE GEN HOMOLOG 1 binding#GO:0005488;nucleic acid binding#GO:0003676;four-way junction DNA binding#GO:0000400;nuclease activity#GO:0004518;DNA binding#GO:0003677;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;response to stress#GO:0006950;cellular process#GO:0009987;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HELRO|EnsemblGenome=HelroG104131|UniProtKB=T1EDJ8 T1EDJ8 20194650 PTHR11638:SF93 ATP-DEPENDENT CLP PROTEASE MITOCHONDRIAL DISAGGREGASE hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular response to stress#GO:0033554;response to temperature stimulus#GO:0009266;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to heat#GO:0034605;response to heat#GO:0009408;response to stress#GO:0006950;response to abiotic stimulus#GO:0009628 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;protease#PC00190 HELRO|EnsemblGenome=HelroG72949|UniProtKB=T1G177 T1G177 20214825 PTHR12377:SF0 CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG168365|UniProtKB=T1F0H4 T1F0H4 20202324 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG82100|UniProtKB=T1G4M7 T1G4M7 20216025 PTHR24229:SF114 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;peptide binding#GO:0042277;neuropeptide binding#GO:0042923 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG78775|UniProtKB=T1G3F6 T1G3F6 20215604 PTHR19321:SF57 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;spindle assembly#GO:0051225;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;nuclear division#GO:0000280;organelle assembly#GO:0070925;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278 cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG192402|UniProtKB=T1FTW9 T1FTW9 20212266 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded RNA binding#GO:0003725 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG134275|UniProtKB=T1EI38 T1EI38 20196238 PTHR24418:SF479 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG162756|UniProtKB=T1ET34 T1ET34 20199734 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN APPLE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185352|UniProtKB=T1FMQ0 T1FMQ0 20210099 PTHR19139:SF199 AQUAPORIN TRANSPORTER AQUAPORIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG179160|UniProtKB=T1FEA3 T1FEA3 20207152 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG190508|UniProtKB=T1FS21 T1FS21 20211618 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185490|UniProtKB=T1FMW0 T1FMW0 20210159 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER KARMOISIN, ISOFORM B transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HELRO|EnsemblGenome=HelroG178270|UniProtKB=T1FD06 T1FD06 20206705 PTHR11902:SF1 ENOLASE ENOLASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;phosphopyruvate hydratase activity#GO:0004634 carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;primary metabolic process#GO:0044238;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleotide catabolic process#GO:0009166;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine-containing compound catabolic process#GO:0072523;ADP catabolic process#GO:0046032;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150 cytosol#GO:0005829;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG185261|UniProtKB=T1FMK6 T1FMK6 20210055 PTHR11977:SF130 VILLIN SEVERIN binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;regulation of actin filament depolymerization#GO:0030834;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin filament length#GO:0030832;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG179683|UniProtKB=T1FF09 T1FF09 20207408 PTHR31802:SF41 32 KDA HEAT SHOCK PROTEIN-RELATED TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG83069|UniProtKB=T1G500 T1G500 20216148 PTHR10687:SF96 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810 vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network membrane#GO:0032588;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG78857|UniProtKB=T1G3G4 T1G3G4 20215612 PTHR12893:SF0 GOLGI REASSEMBLY STACKING PROTEIN GRASP GRASP65 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG183582|UniProtKB=T1FJV5 T1FJV5 20209104 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97122|UniProtKB=T1G9F6 T1G9F6 20217703 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG188191|UniProtKB=T1FPR5 T1FPR5 20210812 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG186226|UniProtKB=T1FNU3 T1FNU3 20210490 PTHR10827:SF52 RETICULOCALBIN RETICULOCALBIN-3 metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 calmodulin-related#PC00061;calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG185184|UniProtKB=T1FMH4 T1FMH4 20210023 PTHR12027:SF102 WNT RELATED PROTEIN WNT signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;system development#GO:0048731;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HELRO|EnsemblGenome=HelroG86178|UniProtKB=T1G681 T1G681 20216578 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;dynein complex#GO:0030286 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG167463|UniProtKB=T1EZE6 T1EZE6 20201946 PTHR43827:SF13 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN reductase#PC00198 HELRO|EnsemblGenome=HelroG172172|UniProtKB=T1F541 T1F541 20203940 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER AT17652P-RELATED binding#GO:0005488;signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194896|UniProtKB=T1FWJ3 T1FWJ3 20213188 PTHR13063:SF10 ENOS INTERACTING PROTEIN NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG155212|UniProtKB=T1ELH6 T1ELH6 20197426 PTHR34179:SF1 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG193074|UniProtKB=T1FUL6 T1FUL6 20212512 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG107931|UniProtKB=T1EEE1 T1EEE1 20194943 PTHR12442:SF22 DYNEIN INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED binding#GO:0005488;protein binding#GO:0005515 microtubule-based transport#GO:0099111;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;localization#GO:0051179;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based movement#GO:0007018 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG88997|UniProtKB=T1G780 T1G780 20216927 PTHR12968:SF1 B9 DOMAIN-CONTAINING B9 DOMAIN-CONTAINING PROTEIN 1 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;ciliary transition zone#GO:0035869;cilium#GO:0005929;membrane-bounded organelle#GO:0043227 structural protein#PC00211 HELRO|EnsemblGenome=HelroG185480|UniProtKB=T1FMV6 T1FMV6 20210155 PTHR12831:SF0 TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3 cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;response to stimulus#GO:0050896;DNA-templated transcription initiation#GO:0006352;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleotide-excision repair#GO:0006289;gene expression#GO:0010467 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIIH core complex#GO:0000439 RNA metabolism protein#PC00031;general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HELRO|EnsemblGenome=HelroG116537|UniProtKB=T1EGF7 T1EGF7 20195659 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG113173|UniProtKB=T1EFQ6 T1EFQ6 20195408 PTHR11043:SF0 ZETA-COAT PROTEIN COATOMER SUBUNIT ZETA intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of protein localization#GO:0045184;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;intra-Golgi vesicle-mediated transport#GO:0006891 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;COPI-coated vesicle#GO:0030137 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG166386|UniProtKB=T1EY27 T1EY27 20201477 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN voltage-gated calcium channel activity#GO:0005245;channel regulator activity#GO:0016247;channel activity#GO:0015267;transporter regulator activity#GO:0141108;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;localization#GO:0051179;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transmission of nerve impulse#GO:0019226;system process#GO:0003008 postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG184132|UniProtKB=T1FKM9 T1FKM9 20209378 PTHR24034:SF200 EGF-LIKE DOMAIN-CONTAINING PROTEIN FI18763P1-RELATED extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG172618|UniProtKB=T1F5N0 T1F5N0 20204129 PTHR47510:SF14 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63375|UniProtKB=T1FXF0 T1FXF0 20213498 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG107720|UniProtKB=T1EEC5 T1EEC5 20194927 PTHR10605:SF77 HEPARAN SULFATE SULFOTRANSFERASE BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE deacetylase activity#GO:0019213;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740;deacylase activity#GO:0160215 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;transferase#PC00220 HELRO|EnsemblGenome=HelroG183164|UniProtKB=T1FJ88 T1FJ88 20208887 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182851|UniProtKB=T1FIV1 T1FIV1 20208750 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746 HELRO|EnsemblGenome=HelroG194536|UniProtKB=T1FW61 T1FW61 20213057 PTHR14309:SF10 EXPRESSED PROTEIN PH DOMAIN-CONTAINING PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG192104|UniProtKB=T1FTK5 T1FTK5 20212152 PTHR13161:SF15 SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG macromolecule metabolic process#GO:0043170;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;alternative mRNA splicing, via spliceosome#GO:0000380;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG65938|UniProtKB=T1FYE6 T1FYE6 20213844 PTHR23064:SF32 TROPONIN CALTRACTIN ICL1D actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG187002|UniProtKB=T1FP53 T1FP53 20210600 PTHR24031:SF25 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX46-RELATED RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG74935|UniProtKB=T1G1Y1 T1G1Y1 20215079 PTHR38537:SF17 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG175626|UniProtKB=T1F9F9 T1F9F9 20205458 PTHR45638:SF25 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;monoatomic cation transmembrane transporter activity#GO:0008324;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;monoatomic ion channel activity#GO:0005216;heterocyclic compound binding#GO:1901363;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;channel activity#GO:0015267;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261 sensory perception#GO:0007600;nervous system process#GO:0050877;transport#GO:0006810;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 ligand-gated ion channel#PC00141;ion channel#PC00133 HELRO|EnsemblGenome=HelroG104628|UniProtKB=T1EDM7 T1EDM7 20194679 PTHR47960:SF17 DEAD-BOX ATP-DEPENDENT RNA HELICASE 50 ATP-DEPENDENT RNA HELICASE DDX6-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of translation#GO:0006417;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;cellular component assembly#GO:0022607;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;P-body assembly#GO:0033962;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cytoplasmic stress granule assembly#GO:0034063;negative regulation of translation#GO:0017148;organelle assembly#GO:0070925 organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG109762|UniProtKB=T1EEW3 T1EEW3 20195115 PTHR22599:SF21 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 2 enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG158479|UniProtKB=T1EMU6 T1EMU6 20197896 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86044|UniProtKB=T1G664 T1G664 20216561 PTHR11800:SF2 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG76513|UniProtKB=T1G2K8 T1G2K8 20215306 PTHR13113:SF1 ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL cellular process#GO:0009987;activation of immune response#GO:0002253;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;cell surface receptor signaling pathway#GO:0007166;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune system process#GO:0002376;positive regulation of innate immune response#GO:0045089;immune response#GO:0006955;activation of innate immune response#GO:0002218;response to other organism#GO:0051707;biological regulation#GO:0065007;toll-like receptor 4 signaling pathway#GO:0034142;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>ECSIT#P01349 HELRO|EnsemblGenome=HelroG174268|UniProtKB=T1F7W9 T1F7W9 20204918 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159618|UniProtKB=T1EP89 T1EP89 20198389 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164551|UniProtKB=T1EVK4 T1EVK4 20200604 PTHR16029:SF11 CENTROSOMAL PROTEIN OF 192 KDA CENTROSOMAL PROTEIN OF 192 KDA organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle assembly#GO:0070925;protein localization to organelle#GO:0033365;mitotic cell cycle#GO:0000278;protein localization to centrosome#GO:0071539;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;spindle organization#GO:0007051;protein localization to microtubule cytoskeleton#GO:0072698;mitotic spindle assembly#GO:0090307;mitotic sister chromatid segregation#GO:0000070;macromolecule localization#GO:0033036;protein localization to microtubule organizing center#GO:1905508;nuclear division#GO:0000280;mitotic spindle organization#GO:0007052;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;protein localization to cytoskeleton#GO:0044380;sister chromatid segregation#GO:0000819;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HELRO|EnsemblGenome=HelroG194246|UniProtKB=T1FVU8 T1FVU8 20212944 PTHR43806:SF7 PEPTIDASE S8 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 serine protease#PC00203 HELRO|EnsemblGenome=HelroG192271|UniProtKB=T1FTS3 T1FTS3 20212220 PTHR31658:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160665|UniProtKB=T1EQK7 T1EQK7 20198857 PTHR31551:SF1 PRE-MRNA-SPLICING FACTOR CWF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 12 U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA processing factor#PC00147;RNA splicing factor#PC00148 HELRO|EnsemblGenome=HelroG105143|UniProtKB=T1EDR4 T1EDR4 20194716 PTHR10778:SF4 SOLUTE CARRIER FAMILY 35 MEMBER B NUCLEOTIDE SUGAR TRANSPORTER SLC35B4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932 transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleotide-sugar transmembrane transport#GO:0015780;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG191161|UniProtKB=T1FSP0 T1FSP0 20211837 PTHR11630:SF44 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM2 ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 double-strand break repair via break-induced replication#GO:0000727;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;cell cycle DNA replication#GO:0044786;DNA metabolic process#GO:0006259;nuclear DNA replication#GO:0033260;mitotic DNA replication#GO:1902969;DNA damage response#GO:0006974;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;double-strand break repair#GO:0006302;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 intracellular organelle#GO:0043229;MCM complex#GO:0042555;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG72040|UniProtKB=T1G0U5 T1G0U5 20214693 PTHR43684:SF11 FAMILY NOT NAMED CHROMO DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;microbody#GO:0042579;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;peroxisome#GO:0005777;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HELRO|EnsemblGenome=HelroG162023|UniProtKB=T1ES55 T1ES55 PTHR46888:SF18 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED CCHC-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192637|UniProtKB=T1FU54 T1FU54 20212350 PTHR24270:SF8 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED VITELLOGENIN RECEPTOR YL plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG165981|UniProtKB=T1EXJ1 T1EXJ1 20201291 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174553|UniProtKB=T1F890 T1F890 20205039 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD CASPASE DRONC positive regulation of signaling#GO:0023056;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191971|UniProtKB=T1FTG9 T1FTG9 20212116 PTHR33494:SF1 OS02G0793800 PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG190661|UniProtKB=T1FS67 T1FS67 20211664 PTHR12913:SF1 UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN COLD SHOCK DOMAIN-CONTAINING PROTEIN E1 protein-RNA adaptor activity#GO:0140517;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG161743|UniProtKB=T1ERV3 T1ERV3 20199303 PTHR12766:SF11 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX HISTONE-BINDING DOMAIN-CONTAINING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84863|UniProtKB=T1G5P8 T1G5P8 20216395 PTHR13303:SF0 PREFOLDIN SUBUNIT 2 PREFOLDIN SUBUNIT 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 protein-containing complex#GO:0032991 chaperone#PC00072 HELRO|EnsemblGenome=HelroG72348|UniProtKB=T1G0Y7 T1G0Y7 20214735 PTHR12589:SF10 PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG88492|UniProtKB=T1G733 T1G733 20216880 PTHR12914:SF2 PARTNER OF SLD5 DNA REPLICATION COMPLEX GINS PROTEIN PSF1 mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;cell cycle DNA replication#GO:0044786;mitotic DNA replication#GO:1902969;DNA metabolic process#GO:0006259;nuclear DNA replication#GO:0033260;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;DNA-templated DNA replication#GO:0006261;DNA strand elongation involved in DNA replication#GO:0006271;mitotic cell cycle#GO:0000278;DNA replication#GO:0006260;cell cycle process#GO:0022402;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;GINS complex#GO:0000811;organelle lumen#GO:0043233;chromosome#GO:0005694;DNA replication preinitiation complex#GO:0031261;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;CMG complex#GO:0071162;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG163725|UniProtKB=T1EUE5 T1EUE5 20200195 PTHR13261:SF0 BRCA2 AND CDKN1A INTERACTING PROTEIN BRCA2 AND CDKN1A-INTERACTING PROTEIN kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cellular process#GO:0009987;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of protein modification process#GO:0031399;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule anchoring#GO:0034453;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;regulation of macromolecule metabolic process#GO:0060255;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;regulation of cellular process#GO:0050794;microtubule cytoskeleton organization#GO:0000226 spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;mitotic spindle pole#GO:0097431;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75815|UniProtKB=T1G2A6 T1G2A6 20215204 PTHR10784:SF0 TRANSLATION INITIATION FACTOR 6 EUKARYOTIC TRANSLATION INITIATION FACTOR 6 binding#GO:0005488;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribosomal large subunit binding#GO:0043023;ribonucleoprotein complex binding#GO:0043021 RNA metabolic process#GO:0016070;cellular localization#GO:0051641;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;nucleic acid biosynthetic process#GO:0141187;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;protein-RNA complex assembly#GO:0022618;localization#GO:0051179;rRNA processing#GO:0006364;nuclear export#GO:0051168;nuclear transport#GO:0051169;organelle localization#GO:0051640;organelle assembly#GO:0070925;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;rRNA metabolic process#GO:0016072;transport#GO:0006810;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribosomal large subunit assembly#GO:0000027;macromolecule biosynthetic process#GO:0009059 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation initiation factor#PC00224 HELRO|EnsemblGenome=HelroG92922|UniProtKB=T1G8N8 T1G8N8 20217435 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG189715|UniProtKB=T1FRA4 T1FRA4 20211351 PTHR16206:SF4 DEP DOMAIN-CONTAINING PROTEIN LET-99 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188138|UniProtKB=T1FPP2 T1FPP2 20210789 PTHR23261:SF77 GROUNDHOG-RELATED GROUND-LIKE DOMAIN-CONTAINING PROTEIN intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG99753|UniProtKB=T1G9V0 T1G9V0 20217846 PTHR19878:SF19 AUTOPHAGY PROTEIN 16-LIKE AUTOPHAGY-RELATED 16, ISOFORM F protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;metabolic process#GO:0008152;organelle assembly#GO:0070925;catabolic process#GO:0009056;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG102185|UniProtKB=T1ED87 T1ED87 20194539 PTHR12856:SF0 TRANSCRIPTION INITIATION FACTOR IIH-RELATED GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1 nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transcription factor TFIIH core complex#GO:0000439;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;transcription factor TFIIH holo complex#GO:0005675;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HELRO|EnsemblGenome=HelroG167074|UniProtKB=T1EYZ3 T1EYZ3 20201793 PTHR11685:SF479 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF217 acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG102838|UniProtKB=T1EDC2 T1EDC2 20194574 PTHR10782:SF94 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 metabolic process#GO:0008152;protein sumoylation#GO:0016925;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;post-translational protein modification#GO:0043687;regulation of nucleobase-containing compound metabolic process#GO:0019219;protein modification by small protein conjugation or removal#GO:0070647;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 Interferon-gamma signaling pathway#P00035>PIAS#P00958 HELRO|EnsemblGenome=HelroG189916|UniProtKB=T1FRH5 T1FRH5 20211422 PTHR10177:SF584 CYCLINS CYCLIN G enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;nucleus#GO:0005634;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG159565|UniProtKB=T1EP62 T1EP62 20198362 PTHR15231:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H carbohydrate derivative metabolic process#GO:1901135;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538 organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG79669|UniProtKB=T1G3S0 T1G3S0 20215718 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;positive regulation of cellular process#GO:0048522;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155894|UniProtKB=T1ELN8 T1ELN8 20197488 PTHR11831:SF5 30S 40S RIBOSOMAL PROTEIN SMALL RIBOSOMAL SUBUNIT PROTEIN US4 rRNA binding#GO:0019843;binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274;ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG155703|UniProtKB=T1ELK9 T1ELK9 20197459 PTHR46472:SF1 NUCLEOREDOXIN NUCLEOREDOXIN oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209 regulation of protein modification process#GO:0031399;regulation of response to stimulus#GO:0048583;regulation of protein ubiquitination#GO:0031396;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of cell communication#GO:0010648;regulation of post-translational protein modification#GO:1901873;negative regulation of protein ubiquitination#GO:0031397;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG103696|UniProtKB=T1EDG8 T1EDG8 20194620 PTHR43671:SF115 SERINE/THREONINE-PROTEIN KINASE NEK SERINE_THREONINE-PROTEIN KINASE NEK2 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle#GO:0007049;cellular component organization#GO:0016043;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;mitotic cell cycle phase transition#GO:0044772;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG97665|UniProtKB=T1G9I5 T1G9I5 20217732 PTHR11388:SF100 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER transporter#PC00227 HELRO|EnsemblGenome=HelroG98101|UniProtKB=T1G9K6 T1G9K6 20217752 PTHR14167:SF124 SH3 DOMAIN-CONTAINING ENDOPHILIN-A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 presynapse#GO:0098793;cytosol#GO:0005829;cytoplasm#GO:0005737;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185718|UniProtKB=T1FN70 T1FN70 20210268 PTHR12642:SF0 RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654 membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233 HELRO|EnsemblGenome=HelroG173235|UniProtKB=T1F6L3 T1F6L3 20204462 PTHR15405:SF0 PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR AAQUETZALLI, ISOFORM A membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG179508|UniProtKB=T1FET4 T1FET4 20207333 PTHR23227:SF87 BUCENTAUR RELATED PROTEIN CFDP2 HELRO|EnsemblGenome=HelroG184035|UniProtKB=T1FKG8 T1FKG8 20209317 PTHR13351:SF1 RENIN RECEPTOR RENIN RECEPTOR regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG168361|UniProtKB=T1F0H0 T1F0H0 20202320 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG107813|UniProtKB=T1EEC9 T1EEC9 20194931 PTHR45780:SF2 ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG194728|UniProtKB=T1FWC7 T1FWC7 20213122 PTHR34724:SF2 OS12G0596101 PROTEIN EXPRESSED PROTEIN HELRO|EnsemblGenome=HelroG174656|UniProtKB=T1F8C8 T1F8C8 20205077 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG187260|UniProtKB=T1FP83 T1FP83 20210630 PTHR14269:SF4 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CAT EYE SYNDROME CRITICAL REGION PROTEIN 5 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;organophosphate biosynthetic process#GO:0090407 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190776|UniProtKB=T1FSA4 T1FSA4 20211701 PTHR10857:SF102 COPINE COPINE-3 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 cellular response to chemical stimulus#GO:0070887;response to metal ion#GO:0010038;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;response to calcium ion#GO:0051592;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG62886|UniProtKB=T1FX67 T1FX67 20213415 PTHR16470:SF0 UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1 UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1 HELRO|EnsemblGenome=HelroG191256|UniProtKB=T1FST2 T1FST2 20211879 PTHR12693:SF3 MENIN MENIN double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 transcription initiation at RNA polymerase II promoter#GO:0006367;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;transcription initiation-coupled chromatin remodeling#GO:0045815;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;DNA-templated transcription initiation#GO:0006352;chromatin remodeling#GO:0006338;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;chromosome#GO:0005694;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 CCKR signaling map#P06959>MEN1#P07084 HELRO|EnsemblGenome=HelroG182281|UniProtKB=T1FI09 T1FI09 20208458 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171005|UniProtKB=T1F3P4 T1F3P4 20203443 PTHR45627:SF1 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 8 adenylate cyclase activity#GO:0004016;lyase activity#GO:0016829;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;G protein-coupled receptor signaling pathway#GO:0007186;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 adenylate cyclase#PC00043 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;GABA-B receptor II signaling#P05731>AC#P05760;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719 HELRO|EnsemblGenome=HelroG190664|UniProtKB=T1FS69 T1FS69 20211666 PTHR46421:SF1 PROGRAMMED CELL DEATH PROTEIN 2-LIKE US5 ASSEMBLY CHAPERONE PDCD2L programmed cell death#GO:0012501;cellular process#GO:0009987;cell death#GO:0008219;apoptotic process#GO:0006915 HELRO|EnsemblGenome=HelroG158402|UniProtKB=T1EMR6 T1EMR6 20197866 PTHR46103:SF3 RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;rRNA (guanine) methyltransferase activity#GO:0016435;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173 nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG173373|UniProtKB=T1F6Q7 T1F6Q7 20204506 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84252|UniProtKB=T1G5G5 T1G5G5 20216312 PTHR24073:SF128 DRAB5-RELATED RAB-LIKE PROTEIN 3 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein transport#GO:0015031;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 G-protein#PC00020;small GTPase#PC00208 HELRO|EnsemblGenome=HelroG96186|UniProtKB=T1G9A6 T1G9A6 20217653 PTHR11977:SF142 VILLIN PROTEIN FLIGHTLESS-1 HOMOLOG phospholipid binding#GO:0005543;cytoskeletal protein binding#GO:0008092;phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877 cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;regulation of protein-containing complex disassembly#GO:0043244;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;membraneless organelle assembly#GO:0140694;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;actin cytoskeleton organization#GO:0030036;regulation of supramolecular fiber organization#GO:1902903;myofibril assembly#GO:0030239;negative regulation of cellular component organization#GO:0051129;supramolecular fiber organization#GO:0097435;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;actin filament capping#GO:0051693;organelle assembly#GO:0070925;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;cellular anatomical entity morphogenesis#GO:0032989;regulation of anatomical structure size#GO:0090066;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;striated muscle cell development#GO:0055002;regulation of actin filament length#GO:0030832;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;actin polymerization or depolymerization#GO:0008154;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;negative regulation of cellular process#GO:0048523;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;negative regulation of organelle organization#GO:0010639;negative regulation of protein-containing complex assembly#GO:0031333;anatomical structure development#GO:0048856;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927 nucleus#GO:0005634;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG163378|UniProtKB=T1ETZ3 T1ETZ3 20200043 PTHR10012:SF0 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function activator activity#GO:0140677;cis-trans isomerase activity#GO:0016859;catalytic activity#GO:0003824;enzyme activator activity#GO:0008047;phosphatase regulator activity#GO:0019208;catalytic activity, acting on a protein#GO:0140096;phosphatase activator activity#GO:0019211;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;molecular function regulator activity#GO:0098772 microtubule cytoskeleton organization#GO:0000226;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;organelle organization#GO:0006996;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 phosphatase activator#PC00182 HELRO|EnsemblGenome=HelroG163279|UniProtKB=T1ETV2 T1ETV2 20200002 PTHR13077:SF6 SELENOPROTEIN F SELENOPROTEIN F oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG191970|UniProtKB=T1FTG8 T1FTG8 20212115 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG166802|UniProtKB=T1EYJ7 T1EYJ7 20201647 PTHR33395:SF23 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE HELRO|EnsemblGenome=HelroG68144|UniProtKB=T1FZA9 T1FZA9 20214157 PTHR47537:SF2 CUBILIN SOL1, ISOFORM C cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG66918|UniProtKB=T1FYS9 T1FYS9 20213977 PTHR13291:SF0 JOSEPHIN 1, 2 JOSEPHIN-LIKE PROTEIN catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG78031|UniProtKB=T1G370 T1G370 20215518 PTHR15350:SF5 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 COP9 SIGNALOSOME COMPLEX SUBUNIT 7 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HELRO|EnsemblGenome=HelroG194116|UniProtKB=T1FVP8 T1FVP8 20212894 PTHR10075:SF110 BASIGIN RELATED IG-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG179462|UniProtKB=T1FER2 T1FER2 20207311 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG170307|UniProtKB=T1F2W7 T1F2W7 20203166 PTHR42884:SF38 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;proteolysis#GO:0006508 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;DPP signaling pathway#P06213>FUR1#P06290;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Activin beta signaling pathway#P06210>FUR1#P06238;DPP-SCW signaling pathway#P06212>FUR1#P06263;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;Endothelin signaling pathway#P00019>furin#P00575;MYO signaling pathway#P06215>FUR1#P06318;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HELRO|EnsemblGenome=HelroG103917|UniProtKB=T1EDI4 T1EDI4 20194636 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG65936|UniProtKB=T1FYE5 T1FYE5 20213843 PTHR46063:SF1 KELCH DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG103288|UniProtKB=T1EDF4 T1EDF4 20194606 PTHR10361:SF70 SODIUM-BILE ACID COTRANSPORTER P3 PROTEIN-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 primary active transporter#PC00068 HELRO|EnsemblGenome=HelroG117076|UniProtKB=T1EGK0 T1EGK0 20195701 PTHR12474:SF0 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN HOMOLOG oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;cation binding#GO:0043169;organic acid binding#GO:0043177;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;amino acid binding#GO:0016597 regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;positive regulation of cellular process#GO:0048522;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;regulation of cell communication#GO:0010646;response to nitrogen compound#GO:1901698;response to stress#GO:0006950;positive regulation of autophagy#GO:0010508;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to acid chemical#GO:0001101;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;cellular response to amino acid starvation#GO:0034198;negative regulation of signal transduction#GO:0009968;negative regulation of TORC1 signaling#GO:1904262;regulation of macroautophagy#GO:0016241;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;positive regulation of macroautophagy#GO:0016239;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG72500|UniProtKB=T1G109 T1G109 20214757 PTHR10902:SF0 60S RIBOSOMAL PROTEIN L35A LARGE RIBOSOMAL SUBUNIT PROTEIN EL33 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192292|UniProtKB=T1FTS8 T1FTS8 20212225 PTHR10501:SF49 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B PROTEIN COUCH POTATO RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG183694|UniProtKB=T1FK21 T1FK21 20209170 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN SAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185790|UniProtKB=T1FNA4 T1FNA4 20210301 PTHR46016:SF1 ZINC FINGER, RING/FYVE/PHD-TYPE ZINC FINGER PROTEIN 313 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 HELRO|EnsemblGenome=HelroG177523|UniProtKB=T1FBU4 T1FBU4 20206293 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90436|UniProtKB=T1G7R3 T1G7R3 20217110 PTHR11374:SF3 UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE UDP-GLUCOSE 6-DEHYDROGENASE dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190537|UniProtKB=T1FS30 T1FS30 20211627 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN-LIKE PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel regulator activity#GO:0016247;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 localization within membrane#GO:0051668;regulation of signaling#GO:0023051;nervous system process#GO:0050877;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;localization#GO:0051179;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;cellular localization#GO:0051641;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transmission of nerve impulse#GO:0019226;system process#GO:0003008;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177 signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG95885|UniProtKB=T1G986 T1G986 20217633 PTHR22990:SF20 F-BOX ONLY PROTEIN F-BOX ONLY PROTEIN 11 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG96873|UniProtKB=T1G9E1 T1G9E1 20217688 PTHR11099:SF0 VACUOLAR SORTING PROTEIN 35 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;endocytic recycling#GO:0032456;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;protein localization to cell periphery#GO:1990778;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of protein localization to membrane#GO:0090150;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;endosome to plasma membrane protein transport#GO:0099638;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;late endosome#GO:0005770;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;retromer complex#GO:0030904;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74048|UniProtKB=T1G1L6 T1G1L6 20214964 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG141821|UniProtKB=T1EJ43 T1EJ43 20196593 PTHR11003:SF356 POTASSIUM CHANNEL, SUBFAMILY K RE21922P voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG81535|UniProtKB=T1G4F5 T1G4F5 20215953 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG63652|UniProtKB=T1FXI7 T1FXI7 20213535 PTHR45832:SF26 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG185521|UniProtKB=T1FMX5 T1FMX5 20210174 PTHR13902:SF67 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED NUCLEAR RECEPTOR-BINDING PROTEIN HOMOLOG phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188177|UniProtKB=T1FPQ8 T1FPQ8 20210805 PTHR44186:SF1 FAMILY NOT NAMED BBSOME COMPLEX MEMBER BBS4 HELRO|EnsemblGenome=HelroG158869|UniProtKB=T1ENC7 T1ENC7 20198077 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156213|UniProtKB=T1ELS9 T1ELS9 20197529 PTHR45677:SF10 GLUTAMATE DECARBOXYLASE-RELATED GLUTAMATE DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HELRO|EnsemblGenome=HelroG163628|UniProtKB=T1EUA6 T1EUA6 20200156 PTHR10732:SF0 40S RIBOSOMAL PROTEIN S17 SMALL RIBOSOMAL SUBUNIT PROTEIN ES17 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG179415|UniProtKB=T1FEN8 T1FEN8 20207287 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG186037|UniProtKB=T1FNK7 T1FNK7 20210404 PTHR10656:SF70 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-LIKE nucleotidyltransferase#PC00174;transferase#PC00220 HELRO|EnsemblGenome=HelroG144776|UniProtKB=T1EJG3 T1EJG3 20196713 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG83659|UniProtKB=T1G588 T1G588 20216235 PTHR24056:SF593 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 8 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911;mediator complex#GO:0016592;transferase complex#GO:1990234 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG176934|UniProtKB=T1FB22 T1FB22 20206021 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;neurotransmitter receptor activity#GO:0030594 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG133959|UniProtKB=T1EI29 T1EI29 20196229 PTHR11040:SF223 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG99551|UniProtKB=T1G9T4 T1G9T4 20217830 PTHR12629:SF0 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;alcohol metabolic process#GO:0006066;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG143376|UniProtKB=T1EJA4 T1EJA4 20196654 PTHR14742:SF0 RIBONUCLEASE P SUBUNIT P21 RIBONUCLEASE P PROTEIN SUBUNIT P21 RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;endonuclease complex#GO:1905348;organelle#GO:0043226;multimeric ribonuclease P complex#GO:0030681;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleolar ribonuclease P complex#GO:0005655;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;ribonuclease P complex#GO:0030677;endoribonuclease complex#GO:1902555;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 endoribonuclease#PC00094 HELRO|EnsemblGenome=HelroG177285|UniProtKB=T1FBG3 T1FBG3 20206162 PTHR46731:SF1 F-BOX ONLY PROTEIN 15 F-BOX ONLY PROTEIN 15 transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005 HELRO|EnsemblGenome=HelroG72885|UniProtKB=T1G167 T1G167 20214815 PTHR48024:SF67 GEO13361P1-RELATED RNA-BINDING PROTEIN 24-A-LIKE PROTEIN RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 HELRO|EnsemblGenome=HelroG182146|UniProtKB=T1FHT9 T1FHT9 20208388 PTHR13297:SF5 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 Golgi apparatus subcompartment#GO:0098791;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG108992|UniProtKB=T1EEP7 T1EEP7 20195049 PTHR46803:SF5 E3 UBIQUITIN-PROTEIN LIGASE CHIP E3 UBIQUITIN-PROTEIN LIGASE CHIP binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein-folding chaperone binding#GO:0051087;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;response to misfolded protein#GO:0051788;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of proteolysis#GO:0030162;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;cellular response to topologically incorrect protein#GO:0035967;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;regulation of cellular process#GO:0050794;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;cellular response to misfolded protein#GO:0071218;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;post-translational protein modification#GO:0043687 intracellular organelle#GO:0043229;I band#GO:0031674;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>CHIP#P01214 HELRO|EnsemblGenome=HelroG179399|UniProtKB=T1FEN4 T1FEN4 20207283 PTHR12011:SF481 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG83625|UniProtKB=T1G583 T1G583 20216230 PTHR24346:SF45 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SNF-RELATED SERINE_THREONINE-PROTEIN KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185989|UniProtKB=T1FNI9 T1FNI9 20210386 PTHR31804:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HELRO|EnsemblGenome=HelroG185022|UniProtKB=T1FMA7 T1FMA7 20209956 PTHR12170:SF3 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED GH10162P ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HELRO|EnsemblGenome=HelroG74876|UniProtKB=T1G1X0 T1G1X0 20215068 PTHR11827:SF103 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108 metal ion transport#GO:0030001;sodium ion transport#GO:0006814;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HELRO|EnsemblGenome=HelroG186250|UniProtKB=T1FNV3 T1FNV3 20210500 PTHR45991:SF1 PACHYTENE CHECKPOINT PROTEIN 2 PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;signaling#GO:0023052;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988;meiosis I#GO:0007127;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA recombination#GO:0006310;regulation of cellular process#GO:0050794;homologous recombination#GO:0035825;reproductive process#GO:0022414;negative regulation of organelle organization#GO:0010639;primary metabolic process#GO:0044238;negative regulation of cellular component organization#GO:0051129;nucleic acid metabolic process#GO:0090304;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;organelle fission#GO:0048285;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;regulation of reproductive process#GO:2000241;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948 chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185687|UniProtKB=T1FN54 T1FN54 20210252 PTHR43851:SF3 FAMILY NOT NAMED COENZYME Q8 metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;ketone metabolic process#GO:0042180;ubiquinone biosynthetic process#GO:0006744;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG183103|UniProtKB=T1FJ54 T1FJ54 20208853 PTHR10024:SF374 SYNAPTOTAGMIN SYNAPTOTAGMIN-5-LIKE protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149 transport#GO:0006810;establishment of localization#GO:0051234;regulation of localization#GO:0032879;regulation of transport#GO:0051049;synaptic signaling#GO:0099536;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signaling#GO:0023052 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG99557|UniProtKB=T1G9T5 T1G9T5 20217831 PTHR45747:SF21 HISTONE-LYSINE N-METHYLTRANSFERASE E(Z) HISTONE-LYSINE N-METHYLTRANSFERASE E(Z) N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;chromatin binding#GO:0003682;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;binding#GO:0005488;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;PcG protein complex#GO:0031519;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG162380|UniProtKB=T1ESL0 T1ESL0 20199560 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE HELRO|EnsemblGenome=HelroG108598|UniProtKB=T1EEK7 T1EEK7 20195009 PTHR48012:SF10 STERILE20-LIKE KINASE, ISOFORM B-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185040|UniProtKB=T1FMB6 T1FMB6 20209965 PTHR31964:SF113 ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN USPA DOMAIN-CONTAINING PROTEIN hydrolase#PC00121 HELRO|EnsemblGenome=HelroG170189|UniProtKB=T1F2R9 T1F2R9 20203118 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;serine protease#PC00203 HELRO|EnsemblGenome=HelroG165373|UniProtKB=T1EWN8 T1EWN8 20200988 PTHR48622:SF1 SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156862|UniProtKB=T1EM21 T1EM21 20197621 PTHR13042:SF0 UBIQUITIN-LIKE PROTEIN 5 UBIQUITIN-LIKE PROTEIN 5 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HELRO|EnsemblGenome=HelroG182833|UniProtKB=T1FIU0 T1FIU0 20208739 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163102|UniProtKB=T1ETN4 T1ETN4 20199934 PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HELRO|EnsemblGenome=HelroG157043|UniProtKB=T1EM54 T1EM54 20197654 PTHR11875:SF49 TESTIS-SPECIFIC Y-ENCODED PROTEIN PROTEIN SET protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG169863|UniProtKB=T1F2E0 T1F2E0 20202990 PTHR10075:SF130 BASIGIN RELATED NEURAL CELL ADHESION MOLECULE L1 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG183531|UniProtKB=T1FJS9 T1FJS9 20209078 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171209|UniProtKB=T1F3Y1 T1F3Y1 20203530 PTHR19143:SF468 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987;cell-substrate adhesion#GO:0031589 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158885|UniProtKB=T1END5 T1END5 20198085 PTHR15644:SF2 OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1 OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HELRO|EnsemblGenome=HelroG176712|UniProtKB=T1FAT3 T1FAT3 20205932 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172940|UniProtKB=T1F663 T1F663 20204312 PTHR11690:SF305 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED AMILORIDE-SENSITIVE SODIUM CHANNEL passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HELRO|EnsemblGenome=HelroG172375|UniProtKB=T1F585 T1F585 20203984 PTHR37445:SF3 PROTEIN CBG24663 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186788|UniProtKB=T1FP36 T1FP36 20210583 PTHR11062:SF381 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-2 acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG131625|UniProtKB=T1EHW2 T1EHW2 20196162 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167